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[PMID]: 29499665
[Au] Autor:Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L
[Ad] Address:People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
[Ti] Title:Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis.
[So] Source:BMC Ophthalmol;18(1):65, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration.
[Mh] MeSH terms primary: Anti-Infective Agents/therapeutic use
Corneal Stroma/metabolism
Corneal Ulcer/drug therapy
Cross-Linking Reagents
Eye Infections, Fungal/drug therapy
Fusariosis/drug therapy
Fusarium/drug effects
[Mh] MeSH terms secundary: Animals
Collagen/metabolism
Colony Count, Microbial
Corneal Ulcer/metabolism
Corneal Ulcer/microbiology
Disease Models, Animal
Eye Infections, Fungal/metabolism
Eye Infections, Fungal/microbiology
Fusariosis/metabolism
Fusariosis/microbiology
Fusarium/isolation & purification
Male
Mice
Mice, Inbred C57BL
Photosensitizing Agents/therapeutic use
Riboflavin/therapeutic use
Ultraviolet Rays
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0727-0

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[PMID]: 29211700
[Au] Autor:Kim MJ; Kim JH; Jeon HS; Wee WR; Hyon JY
[Ad] Address:*Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; and†Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.
[Ti] Title:Effect of Histocompatibility Y Antigen Matching on Graft Survival in Primary Penetrating Keratoplasty.
[So] Source:Cornea;37(1):33-38, 2018 Jan.
[Is] ISSN:1536-4798
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To investigate the influence of histocompatibility Y (H-Y) antigen matching on corneal graft survival in primary penetrating keratoplasty (PK). METHODS: Medical records of patients who underwent primary PK at Seoul National University Bundang Hospital between June 2005 and October 2015 were retrospectively analyzed. The eyes were classified into 2 groups: H-Y-compatible (115 eyes) and H-Y-incompatible (23 eyes). The H-Y-compatible group included donor/recipient combinations of male/male (57 eyes), female/male (44 eyes), and female/female (14 eyes). The H-Y-incompatible group included the male/female (23 eyes) combination alone. A subgroup analysis of low- and high-risk patients according to preoperative diagnoses was also performed. Survival analysis was conducted using the Kaplan-Meier method; differences between groups were assessed with a log-rank test. RESULTS: A total of 138 eyes from 136 patients (age: 58 ± 18 years) were enrolled. Rejection-free graft survival and graft survival were not significantly different between H-Y-compatible and H-Y-incompatible groups (χ = 0.4, P = 0.548; χ = 1.9; P = 0.17, respectively). Preoperative diagnoses of high-risk cases included those with corneal perforation or thinning (8.7%) and infectious keratitis (7.2%). Low-risk cases included corneal opacity (50.0%), bullous keratopathy (25.4%), keratoconus (5.8%), and corneal dystrophy (2.9%). In the high-risk group, rejection-free graft survival rate was significantly higher in the H-Y-compatible group (χ = 3.9, P = 0.049). CONCLUSIONS: H-Y antigen matching does not influence graft rejection and failure in cases of primary PK. However, matching the H-Y antigen could help reduce graft rejection, especially in preoperatively high-risk patients.
[Mh] MeSH terms primary: Corneal Diseases/surgery
Graft Survival/immunology
H-Y Antigen/immunology
Keratoplasty, Penetrating
[Mh] MeSH terms secundary: Aged
Allografts
Female
Graft Rejection/diagnosis
Histocompatibility Testing
Humans
Male
Middle Aged
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (H-Y Antigen)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001394

  3 / 18451 MEDLINE  
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[PMID]: 29436623
[Au] Autor:Manajit O; Longyant S; Sithigorngul P; Chaivisuthangkura P
[Ad] Address:Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
[Ti] Title:Development of uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification coupled with nanogold probe (UDG-LAMP-AuNP) for specific detection of Pseudomonas aeruginosa.
[So] Source:Mol Med Rep;17(4):5734-5743, 2018 Apr.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Pseudomonas aeruginosa (P. aeruginosa) is an important opportunistic pathogen that causes serious infections in humans, including keratitis in contact lens wearers. Therefore, establishing a rapid, specific and sensitive method for the identification of P. aeruginosa is imperative. In the present study, the uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification combined with nanogold labeled hybridization probe (UDG-LAMP-AuNP) was developed for the detection of P. aeruginosa. UDG-LAMP was performed to prevent carry over contamination and the LAMP reactions can be readily observed using the nanogold probe. A set of 4 primers and a hybridization probe were designed based on the ecfX gene. The UDG-LAMP reactions were performed at 65˚C for 60 min using the ratio of 40% deoxyuridine triphosphate to 60% deoxythymidine triphosphate. The detection of UDG-LAMP products using the nanogold labeled hybridization probe, which appeared as a red-purple color, was examined at 65˚C for 5 min with 40 mM MgSO4. The UDG-LAMP-AuNP demonstrated specificity to all tested isolates of P. aeruginosa without cross reaction to other bacteria. The sensitivity for the detection of pure culture was 1.6x103 colony-forming units (CFU) ml-1 or equivalent to 3 CFU per reaction while that of polymerase chain reaction was 30 CFU per reaction. The detection limit of spiked contact lenses was 1.1x103 CFU ml-1 or equivalent to 2 CFU per reaction. In conclusion, the UDG-LAMP-AuNP assay was rapid, simple, specific and was effective for the identification of P. aeruginosa in contaminated samples.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8557

  4 / 18451 MEDLINE  
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[PMID]: 29517701
[Au] Autor:Fajnkuchen F; Barritault D; Giocanti-Aurégan A
[Ad] Address:Ophthalmology Department, Avicenne Hospital, DHU Vision and Handicaps, APHP, Paris 13 University, Bobigny.
[Ti] Title:Evaluation of a new matrix regenerating agent in patients with Sjögren syndrome and superficial ulcerative keratitis resistant to conventional therapy: A report of 3 cases.
[So] Source:Medicine (Baltimore);97(10):e9935, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Sjögren syndrome (SS) is frequently associated with ulcerative keratitis, which is difficult to treat due to lacrimal tear deficiency and inflammation of the ocular surface. PATIENT CONCERNS: We report the successful additive effect of a matrix regenerating agent (RGTA, Cacicol) in SS patients with severe superficial ulcerative keratitis resistant to conventional therapy. DIAGNOSES: Retrospective, noncomparative case series of patients with primary or secondary SS associated with chronic diffuse keratitis. INTERVENTIONS: All patients (3 women, aged 46, 59, and 84 years) had several years of dry-eye disease history and recurrent keratitis despite having used maximal dose topical therapies including artificial tear substitutes, topical vitamin A, and cyclosporine 0.05% emulsion. All patients suffered from dry, diffuse, and chronic superficial keratitis of at least 75% of the corneal surface, with no sign of corneal neovascularization or opacity. OUTCOMES: RGTA treatment led to a rapid and marked decrease of ocular pain, burning, irritation, foreign body sensation, and improvement of visual acuity. Total diffuse keratitis healing occurred after several months of treatment. Discontinuation of RGTA administration led to the recurrence of severe keratitis; re-introduction of RGTA was successful. No local or systemic adverse effects related to treatment were reported. LESSONS: RGTA treatment was effective and safe in this small series of 3 patients suffering from SS associated with recurrent or chronic superficial ulcerative keratitis resistant to conventional therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1097/MD.0000000000009935

  5 / 18451 MEDLINE  
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[PMID]: 29514379
[Au] Autor:Kampmeier J; Werner JU; Wagner P; Lang GK; Russ D
[Ad] Address:Augenklinik, Universitätsklinikum Ulm.
[Ti] Title:In-vitro-Studie mit subablativem Er:YAG-Laser und Diodenlaser vs. Thermokauter zur Therapie der mikrobiellen Keratitis. [In Vitro Study of Subablative Er : YAG Laser and Diode Laser Therapy vs. Thermal Cautery in Microbial Keratitis].
[So] Source:Klin Monbl Augenheilkd;, 2018 Mar 07.
[Is] ISSN:1439-3999
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND: In microbial keratitis, thermal cautery leads to thermal necrosis associated with germ reduction. Subablative heating of the cornea using an Er : YAG laser or diode laser is an alternative option. Thermal effects and reproducibility of both procedures were investigated. MATERIAL AND METHODS: Thermal effects were monitored with an infrared imaging system. Temperature of stromal tissue of enucleated porcine eyes was measured. Effects of thermal injury were rated by microscopic photography and histopathologic examination. Reduction of living bacteria was visualized by laser scanning microscopy and fluorescent stain on stromal tissue models containing E. coli bacteria. RESULTS: Corneal samples showed thermal damage depths of 110 - 250 µm after thermal cautery at contact times of 1 - 3 s. Superficial temperature ranged from 70 to 80 °C. Thickness of thermal necrosis after laser irradiation was between 50 and 270 µm. Temperature ranged from 60 to 120 °C. Laser scanning microscopy of a stromal tissue model, comprising Escherichia coli bacteria in soft agar, showed a mortification of bacteria over 40% up to 100 µm depth after treatment for 25 s. Treatment with diode laser showed an even better effect: more than 60% of bacteria were dead up to 250 µm depth and more than 50% up to 450 µm depth in the stromal tissue model. CONCLUSIONS: All procedures are able to induce high temperatures in tissue to achieve effective germ reduction in corneal stroma. Effect and reproducibility of the thermal cautery procedure depends on the surgeon's experience. Energy dose and thermal effect can be calculated for the Er : YAG and diode laser procedure to affect the infected stromal layer selectively.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1055/s-0043-125085

  6 / 18451 MEDLINE  
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[PMID]: 29513962
[Au] Autor:Hadas E; Ozarowski M; Derda M; Thiem B; Cholewinski M; Skrzypczak L; Gryszczynska A; Piasecka A
[Ti] Title:THE USE OF EXTRACTS FROM PASSIFLORA SPP. IN HELPING THE TREATMENT OF ACANTHAMOEBIASIS.
[So] Source:Acta Pol Pharm;74(3):921-928, 2017 May.
[Is] ISSN:0001-6837
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Chronic progressive diseases of the central nervous system such as granulomatous amoebic encephalitis, amoebic keratitis, amoebic pneumonitis and also skin infections caused by free-living amoebae (Acanhamoeba spp.) are a significant challenge for pharmacotherapy. This is due to the lack of effective treatment because of encystation, which makes the amoebae highly resistant to anti-amoebic drugs. A very inter- esting and promising source of future drugs in this area are plant materials obtained not only from the habitat but also from plant in vitro culture as an alternative source of biomaterials. Alcoholic extracts from leaves of Passiflora incarnata, P. caerulea, P. alata (Passifloraceae) and from callus cultures were evaluated in vito for amoebicidal activity. Phytochemical analysis showed that all extracts contained phenolic compounds including flavonoids? Biological study revealed that all extracts showed amoebostatic and amoebicidal properties in concentrations from 4 to 12 mg/mL. Extracts of P. alata leaf and callus showed the most effective activities (IC5, 4.01 mg/mL, IC,5 7.29 mg/mL, respectively) after 48 h of exposure, which was correlated with the highest concentration of total phenolics and flavonoids in comparison with other extracts.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  7 / 18451 MEDLINE  
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[PMID]: 29411482
[Au] Autor:Kim S; Thomasy SM; Ramsey D; Zhao M; Mannis MJ; Murphy CJ
[Ad] Address:Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
[Ti] Title:Whorl pattern keratopathies in veterinary and human patients.
[So] Source:Vet Ophthalmol;, 2018 Feb 06.
[Is] ISSN:1463-5224
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The course travelled by corneal epithelial cells from their stem cell niche at the limbus toward the vertex of the cornea is normally not evident due to their transparency, but in certain conditions, the epithelial cells can be rendered visible to the clinician. In such cases, the pathway taken by epithelial cells can manifest as a whorl pattern described using a variety of terms including hurricane keratitis/keratopathy, vortex keratopathy, whorl keratopathy, cornea verticillata, and at times, named after causative agents as exemplified by amiodarone keratopathy. Here, we briefly discuss the terminology used and the spectrum of conditions that can result in keratopathies with whorl patterns in human patients. We review the manifestations of such patterns in veterinary patients and discuss the state of understanding of the underlying forces that create the whorl distribution of epithelial cells on the ocular surface.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1111/vop.12552

  8 / 18451 MEDLINE  
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[PMID]: 29363971
[Au] Autor:Parmar A; Lakshminarayanan R; Iyer A; Mayandi V; Leng Goh ET; Lloyd DG; Chalasani MLS; Verma NK; Prior SH; Beuerman RW; Madder A; Taylor EJ; Singh I
[Ti] Title:Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo.
[So] Source:J Med Chem;61(5):2009-2017, 2018 Mar 08.
[Is] ISSN:1520-4804
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial efficacy. In this work, we designed and synthesized 10 new in vivo ready teixobactin analogues. These analogues showed highly potent antibacterial activities against Staphylococcus aureus, MRSA, and vancomycin-resistant enterococci (VRE) in vitro. One analogue, d-Arg -Leu -teixobactin, 2, was found to be noncytotoxic in vitro and in vivo. Moreover, topical instillation of peptide 2 in a mouse model of S. aureus keratitis decreased the bacterial bioburden (>99.0% reduction) and corneal edema significantly as compared to untreated mouse corneas. Collectively, our results have established the high therapeutic potential of a teixobactin analogue in attenuating bacterial infections and associated severities in vivo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.jmedchem.7b01634

  9 / 18451 MEDLINE  
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[PMID]: 29329175
[Au] Autor:Zuazo F; Astiazaran MC; Rodríguez-Cabrera L; Garcia-Regil P; Chacon-Camacho O; Tovilla-Canales JL; Zenteno JC
[Ad] Address:Department of Orbit and Oculoplastics, Institute of Ophthalmology, Conde de Valenciana, Mexico City, Mexico.
[Ti] Title:Clinical Description, Molecular Analysis of TWIST2 Gene, and Surgical Treatment in a Patient With Barber-Say Syndrome.
[So] Source:Ophthal Plast Reconstr Surg;34(2):e61-e63, 2018 Mar/Apr.
[Is] ISSN:1537-2677
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Barber-Say syndrome is a rare autosomal dominant disease characterized by dysmorphic features, mainly of the eyelids and skin. It is caused by heterozygous mutations in gene TWIST2, localized in chromosome 2q37.3. The authors present the case of a pediatric patient with a clinical diagnosis of Barber-Say syndrome with ocular symptoms related to exposure keratitis. Molecular analysis of her DNA revealed a mutation on TWIST2 gene confirming the diagnosis of Barber-Say syndrome. Surgical treatment of the patient's eyelids resolved her signs and symptoms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1097/IOP.0000000000001036

  10 / 18451 MEDLINE  
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[PMID]: 29230977
[Au] Autor:Jo J; Moon BG; Lee JY
[Ad] Address:Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
[Ti] Title:Scleral Buckling Using a Non-contact Wide-Angle Viewing System with a 25-Gauge Chandelier Endoilluminator.
[So] Source:Korean J Ophthalmol;31(6):533-537, 2017 Dec.
[Is] ISSN:2092-9382
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the outcome of scleral buckling using a non-contact wide-angle viewing system with a 25-gauge chandelier endoilluminator. METHODS: Retrospective analyses of medical records were performed for 17 eyes of 16 patients with primary rhegmatogenous retinal detachment (RRD) without proliferative vitreoretinopathy who had undergone conventional scleral buckling with cryoretinopexy using the combination of a non-contact wide-angle viewing system and chandelier endoillumination. RESULTS: The patients were eight males and five females with a mean age of 26.8 ± 10.2 (range, 11 to 47) years. The mean follow-up period was 7.3 ± 3.1 months. Baseline best-corrected visual acuity was 0.23 ± 0.28 logarithm of the minimum angle of resolution units. Best-corrected visual acuity at the final visit showed improvement (0.20 ± 0.25 logarithm of the minimum angle of resolution units), but the improvement was not statistically significant (p = 0.722). As a surgery-related complication, there was vitreous loss at the end of surgery in one eye. As a postoperative complication, increased intraocular pressure (four cases) and herpes simplex epithelial keratitis (one case) were controlled postoperatively with eye drops. One case of persistent RRD after primary surgery needed additional vitrectomy, and the retina was postoperatively attached. CONCLUSIONS: Scleral buckling with chandelier illumination as a surgical technique for RRD has the advantages of relieving the surgeon's neck pain from prolonged use of the indirect ophthalmoscope and sharing the surgical procedure with another surgical team member. In addition, fine retinal breaks that are hard to identify using an indirect ophthalmoscope can be easily found under the microscope by direct endoillumination.
[Mh] MeSH terms primary: Lighting/instrumentation
Ophthalmoscopes
Retinal Detachment/surgery
Scleral Buckling/instrumentation
[Mh] MeSH terms secundary: Adolescent
Adult
Child
Equipment Design
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retinal Detachment/diagnosis
Retrospective Studies
Surgery, Computer-Assisted
Time Factors
Visual Acuity
Vitreoretinopathy, Proliferative
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171213
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2017.0044


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