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[PMID]: 29086424
[Au] Autor:Carpenter PS; Kendall KA
[Ad] Address:Department of Surgery Division of Otolaryngology-Head and Neck Surgery, University of Utah Health System, Salt Lake City, Utah, U.S.A.
[Ti] Title:MRSA chronic bacterial laryngitis: A growing problem.
[So] Source:Laryngoscope;, 2017 Oct 31.
[Is] ISSN:1531-4995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Chronic bacterial infection of the larynx is characterized by long-standing hoarseness and exudative laryngitis. Prolonged antibiotic therapy is required to clear the infection, and methicillin-resistant staphylococcus aureus (MRSA) may be the responsible pathogen. The objective of this study was to describe the presentation, comorbidities, treatment response, and underlying etiology- including the incidence of MRSA-in our patient population with chronic bacterial laryngitis. METHODS: A review of patients with a diagnosis of chronic bacterial laryngitis from 2012 to 2016 was performed. Diagnosis of chronic bacterial laryngitis was based on clinical history and findings on flexible laryngoscopy. In selected cases, the diagnosis of bacterial laryngitis was confirmed by operative biopsy. Information regarding clinical presentation and course was collected. RESULTS: Twenty-eight patients were included in the study. Twenty-three were treated empirically with Amoxicillin-clavulonic acid for a minimum of 21 days. Twelve of the 23 (52%) had recurrence or nonresolution of infection. Seven of the 12 nonresponders (58%) were found to have MRSA by laryngeal tissue culture. Five patients were treated initially with Sulfamethoxazole and trimethoprim, and all resolved the infection without the need for further treatment. There was a nonstatistically significant increase in smoking and reflux in the MRSA population compared to the non-MRSA group. CONCLUSION: MRSA infection was documented in 30% of patients overall with chronic bacterial laryngitis. Based on the results of the study, a treatment algorithm for management of this unusual patient population is suggested. LEVEL OF EVIDENCE: 4. Laryngoscope, 2017.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:Publisher
[do] DOI:10.1002/lary.26955

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[PMID]: 29083838
[Au] Autor:Basic-Markovic N; Markovic R; Diminic-Lisica I; Radosevic-Quadranti N
[Ti] Title:[GASTROESOPHAGEAL REFLUX DISEASE ­ A MULTIFACETED DISEASE].
[So] Source:Acta Med Croatica;69(4):279-85, 2015 11.
[Is] ISSN:1330-0164
[Cp] Country of publication:Croatia
[La] Language:hrv
[Ab] Abstract:Gastric content reflux to the esophagus is a physiological phenomenon that occasionally occurs after meal. Gastroesophageal reflux disease (GERD) is a state that appears when the quantity of gastric content surpasses its physiological elimination from the esophagus and causes difficulties with or without associated esophageal mucosa damage, as well as alarming symptoms. The symptoms are defined as alarming if they disturb the patient's well-being and are the reason for a visit to the physician. The prevalence of GERD in the Western world is 10%-20% and is based on the estimation of the heartburn incidence as the leading symptom. The dominant symptoms are heartburn and regurgitation, especially after a heavy meal, and are highly specific for GERD. Extraesophageal reflux disease represents a wide range of symptoms connected to the upper and lower respiratory system, such as cough, laryngitis, asthma, chronic obstructive pulmonary disease, hoarseness, sinusitis-postnasal drip syndrome, otitis media, recurrent pneumonia and laryngeal carcinoma. The following tests are used in the reflux differential diagnosis: esophagogastroscopy, laryngoscopy and 24-hour pH monitoring. Patients suspected to suffer from GERD are initially treated with empirical proton pump inhibitor therapy twice a day for one to two months.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process

  3 / 3323 MEDLINE  
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[PMID]: 28980592
[Au] Autor:Kunel'skaya VY; Romanenko SG; Shadrin GB; Krasnikova DI
[Ad] Address:L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152.
[Ti] Title:Rasprostranennost' gribkovoi flory pri khronicheskoi vospalitel'noi patologii gortani. [The prevalence of the fungal flora in association with chronic inflammatory pathology of the larynx].
[So] Source:Vestn Otorinolaringol;82(4):29-31, 2017.
[Is] ISSN:0042-4668
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The present article was designed to analyze the prevalence and clinical features of laryngomycosis associated with chronic inflammatory diseases of the larynx. We examined 430 patients suffering from chronic pharyngitis and found the fungal flora in 100 (23.2%) of them. Diagnostics of the fungal infection was performed by the microscopic study of the stained preparations (including the Gram method, Romanovskiy-Giemsa and fluorescent microscopy). The sowing on elective nutrient media was used. The study revealed the presence of yeast fungi (Candida) in 98 patients (98%) and mold fungi (Aspergillus) in the remaining two (2%). The hyperplastic form of fungal pharyngitis was diagnosed in 55% of the patients. We have identified the following predisposing factors for fungal laryngitis: the gastroesophageal reflux disease in 56% of the patients, smoking in 50%, the long-term use of the removable dentures with the inadequate care for them in 30%, and the consistent use of inhaled corticosteroids in 27%. Hyperglycemia was documented in 6% and the history of long-term treatment with antibiotics in in 10% of the patients. The scheme for the combined antifungal therapy has been developed. Its practical application allowed to achieve the eradication of the fungal flora and to improve the clinical course of chronic laryngitis in 75% of the patients.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:In-Process
[do] DOI:10.17116/otorino201782429-31

  4 / 3323 MEDLINE  
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[PMID]: 28770319
[Au] Autor:Lönnrot M; Lynch KF; Elding Larsson H; Lernmark Å; Rewers MJ; Törn C; Burkhardt BR; Briese T; Hagopian WA; She JX; Simell OG; Toppari J; Ziegler AG; Akolkar B; Krischer JP; Hyöty H; TEDDY Study Group
[Ad] Address:Department of Dermatology, Tampere University Hospital, Teiskontie 35, 33521, Tampere, Finland. maria.lonnrot@uta.fi.
[Ti] Title:Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study.
[So] Source:Diabetologia;60(10):1931-1940, 2017 Oct.
[Is] ISSN:1432-0428
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:AIMS/HYPOTHESIS: Respiratory infections and onset of islet autoimmunity are reported to correlate positively in two small prospective studies. The Environmental Determinants of Diabetes in the Young (TEDDY) study is the largest prospective international cohort study on the environmental determinants of type 1 diabetes that regularly monitors both clinical infections and islet autoantibodies. The aim was to confirm the influence of reported respiratory infections and to further characterise the temporal relationship with autoantibody seroconversion. METHODS: During the years 2004-2009, 8676 newborn babies with HLA genotypes conferring an increased risk of type 1 diabetes were enrolled at 3 months of age to participate in a 15 year follow-up. In the present study, the association between parent-reported respiratory infections and islet autoantibodies at 3 month intervals up to 4 years of age was evaluated in 7869 children. Time-dependent proportional hazard models were used to assess how the timing of respiratory infections related to persistent confirmed islet autoimmunity, defined as autoantibody positivity against insulin, GAD and/or insulinoma antigen-2, concordant at two reference laboratories on two or more consecutive visits. RESULTS: In total, 87,327 parent-reported respiratory infectious episodes were recorded while the children were under study surveillance for islet autoimmunity, and 454 children seroconverted. The number of respiratory infections occurring in a 9 month period was associated with the subsequent risk of autoimmunity (p < 0.001). For each 1/year rate increase in infections, the hazard of islet autoimmunity increased by 5.6% (95% CI 2.5%, 8.8%). The risk association was linked primarily to infections occurring in the winter (HR 1.42 [95% CI 1.16, 1.74]; p < 0.001). The types of respiratory infection independently associated with autoimmunity were common cold, influenza-like illness, sinusitis, and laryngitis/tracheitis, with HRs (95% CI) of 1.38 (1.11, 1.71), 2.37 (1.35, 4.15), 2.63 (1.22, 5.67) and 1.76 (1.04, 2.98), respectively. CONCLUSIONS/INTERPRETATION: Recent respiratory infections in young children correlate with an increased risk of islet autoimmunity in the TEDDY study. Further studies to identify the potential causative viruses with pathogen-specific assays should focus especially on the 9 month time window leading to autoantibody seroconversion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171028
[Lr] Last revision date:171028
[St] Status:In-Process
[do] DOI:10.1007/s00125-017-4365-5

  5 / 3323 MEDLINE  
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[PMID]: 28474185
[Au] Autor:Wang ML; Chen HY; Shih HH
[Ad] Address:Department of Life Science, National Taiwan University, Taipei, 10617, Taiwan, Republic of China.
[Ti] Title:Occurrence and distribution of yellow grub trematodes (Clinostomum complanatum) infection in Taiwan.
[So] Source:Parasitol Res;116(6):1761-1771, 2017 Jun.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Digenetic trematodes of the genus Clinostomum are widely distributed in many species of freshwater fish and are known to cause the zoonotic disease Halzoun. Humans may become accidental hosts if they ingest raw freshwater fish containing metacercaria of Clinostomum complanatum, which causes pharyngitis or laryngitis. The yellow grub parasitizing cultivated ayu (Plecoglossus altivelis) and loach (Misgurnus anguillicaudatus) was one of the most serious problems in fish farms from 1977 to 1979 in Taiwan. The present study revealed, for the first time, frequent occurrence of C. complanatum metacercaria in various fish species in a natural environment, the Dahan River, in Taiwan. We examined 1503 fish specimens belonging to four families and 162 snails representing six species. C. complanatum metacercaria was mainly from the fish family Cyprinidae, and only cercaria from the snail Radix swinhoei was recovered. The prevalence and mean intensity of metacercaria were 9.8% and 9.35 parasites/infected fish, respectively. The prevalence of cercaria was low, 0.62%, in snails. Acrossocheilus paradoxus, Zacco barbata, Zacco pachycephalus, Zacco platypus, Onychostoma barbatula, and Hemibarbus labeo are new host records. Metacercariae were primarily found in the operculum, mandible, muscle, and oral cavity of fish. Morphological description and molecular analysis with 18S rDNA sequencing allowed for rapidly identifying C. complanatum. Encysted and excysted metacercariae cultivated at 22 °C in physiological saline died within 60 h. The mean intensity of infection increased with an increasing length of Z. pachycephalus. We found no association between monthly parasite prevalence and mean intensity at each sampling location. No C. complanatum metacercaria survived after 8 h of salting. The Dahan River has suitable conditions and hosts (snails, fish, and fish-eating birds) for maintaining the life cycle of C. complanatum.
[Mh] MeSH terms primary: Fish Diseases/parasitology
Fishes/parasitology
Trematoda/classification
Trematode Infections/veterinary
[Mh] MeSH terms secundary: Animals
Fish Diseases/epidemiology
Humans
Metacercariae/classification
Metacercariae/isolation & purification
Snails/parasitology
Taiwan/epidemiology
Trematode Infections/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5457-3

  6 / 3323 MEDLINE  
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Brandao, Lenine Garcia

[PMID]: 28658344
[Au] Autor:Rodrigues MG; Araujo VJF; Matos LL; Hojaij FC; Simões CA; Araujo VJF; Ramos DM; Mahmoud RL; Mosca LM; Manta GB; Volpi EM; Brandão LG; Cernea CR
[Ad] Address:Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil.
[Ti] Title:Substernal goiter and laryngopharyngeal reflux.
[So] Source:Arch Endocrinol Metab;61(4):348-353, 2017 Jul-Aug.
[Is] ISSN:2359-4292
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. SUBJECTS AND METHODS: A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014. The selected thyroidectomies were allocated in two groups for study: patients with substernal goiters and patients with voluminous cervical goiter without thoracic extension. Cervical goiters were selected by ultrasonography mensuration. Clinical criterion was used to define substernal goiter. RESULTS: The average thyroid volume in patients with substernal goiter was significantly greater than the average volume in patients with only cervical goiter (p < 0.001). The prevalence of signs of reflux laryngitis at laryngoscopy was significantly greater in substernal goiter patients (p = 0.036). Moreover, substernal goiter was considered as the unique independent variable for high reflux laryngitis signs at laryngoscopy (OR = 2.75; CI95%: 1.05-7.20; p = 0.039) when compared to only cervical goiter patients. CONCLUSION: This study shows a significant association between substernal goiters and signs of laryngopharyngeal reflux at preoperative laryngoscopy. Therefore, when compared with voluminous cervical goiters, the substernal goiters increase the chance of reflux laryngitis signs in patients.
[Mh] MeSH terms primary: Goiter, Substernal/epidemiology
Laryngopharyngeal Reflux/epidemiology
[Mh] MeSH terms secundary: Adult
Aged
Case-Control Studies
Female
Goiter/complications
Goiter/epidemiology
Goiter/physiopathology
Goiter/surgery
Goiter, Substernal/complications
Goiter, Substernal/physiopathology
Goiter, Substernal/surgery
Humans
Laryngopharyngeal Reflux/complications
Laryngopharyngeal Reflux/diagnostic imaging
Laryngoscopy
Male
Middle Aged
Prevalence
Retrospective Studies
Thyroidectomy
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[Js] Journal subset:IM
[Da] Date of entry for processing:170628
[St] Status:MEDLINE

  7 / 3323 MEDLINE  
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[PMID]: 28834976
[Au] Autor:Wuerdemann N; Sharma SJ; Gattenlöhner S; Klußmann JP; Wittekindt C
[Ti] Title:Ulzerierende Laryngitis bei einer 34-jährigen Patientin. [Fibrinous lesions of the larynx in a 34-year old patient].
[So] Source:Laryngorhinootologie;96(10):710-713, 2017 Oct.
[Is] ISSN:1438-8685
[Cp] Country of publication:Germany
[La] Language:ger
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[St] Status:In-Data-Review
[do] DOI:10.1055/s-0043-116664

  8 / 3323 MEDLINE  
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[PMID]: 28541243
[Au] Autor:Ziarno R; Suska A; Kulinowski W; Grudzien-Ziarno A; Kostrzon M; Paciorek M; Skladzien J
[Ad] Address:Studenckie Kolo Naukowe przy Klinice Otolaryngologii UJ CM.
[Ti] Title:Czy smog ma wplyw na czestosc wystepowania zaostrzen przewleklego zapalenia krtani? Analiza na przykladzie mieszkanców województwa malopolskiego.
[So] Source:Otolaryngol Pol;71(3):10-19, 2017 Jun 30.
[Is] ISSN:2300-8423
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Due to dynamic industrialisation smog became a frequent phenomenon in most developing cities. According to the last WHO report from Global Urban Ambient Air Pollution Database, Krakow has been classified in the 11th place among the most polluted cities in Europe. It seems to be an urgent issue because of the influence of air pollution on the condition of upper respiratory tract. Materials & Methods: In December 2015 there were 141 patients aged 17-91 years with upper respiratory tract diseases admitted to the phoniatric outpatient clinic in the University Hospital in Cracow. They suffered from cough, hoarseness and periodic aphonia. On the basis of the results of videolaryngostroboscopy 60 patients with exacerbation of the chronic laryngitis were selected into two numerically equal groups: from Cracow and from other places at least 60 km away. The groups were equal to each other also in three categories: sex, age and voice usage. The patients were referred to the Pedagogical University in Cracow for laryngography to evaluate the movement of the vocal folds and to trace a voice profile. Finally, there were two possible types of treatment - conventional pharmacotherapy or subterraneotherapy in the underground Health Resort in the "Wieliczka" Salt Mine. RESULTS: Pearson correlation coefficient between the distance from the place of residence to Cracow and the scale of exacerbation of inflammation of upper respiratory tract presenting as vocal fold dysfunction was observed (r= 0,617; p<0,05). CONCLUSION: The place of residence (in or out of the industrial area) and exacerbations of chronic laryngitis are highly correlated. Air pollution seems to be the main factor influencing on the condition of upper respiratory tract. In our local conditions of Lesser Poland Voivodeship subterraneotherapy may be an interesting, non-invasive method preventing from exacerbations of upper respiratory tract diseases.
[Mh] MeSH terms primary: Air Pollutants/adverse effects
Air Pollution/adverse effects
Environmental Exposure/adverse effects
Respiratory Tract Infections/epidemiology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Poland/epidemiology
Respiratory Tract Infections/etiology
Risk Assessment
Risk Factors
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Air Pollutants)
[Em] Entry month:1710
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[Js] Journal subset:IM
[Da] Date of entry for processing:170525
[St] Status:MEDLINE
[do] DOI:10.5604/01.3001.0010.0128

  9 / 3323 MEDLINE  
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[PMID]: 28967389
[Au] Autor:Shtraks JP; Toskala E
[Ad] Address:Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, 3440 North Broad Street, Kresge West 312, Philadelphia, PA 19140, USA.
[Ti] Title:Manifestations of Inhalant Allergies Beyond the Nose.
[So] Source:Otolaryngol Clin North Am;, 2017 Sep 26.
[Is] ISSN:1557-8259
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The upper and lower airways are linked epidemiologically and pathophysiologically. The upper and lower airways are considered a single, functional unit characterized by shared immunologic mechanisms, often referred to as the unified airway. Upper and lower airway inflammatory disease frequently coexist in the same patient. Allergic rhinitis and rhinosinusitis are associated with asthma. Treatment of both diseases impacts asthma outcomes. The otolaryngologist may be the first physician to suspect and diagnose asthma in patients with upper airway complaints. A thorough understanding of the relationship between allergic rhinitis, rhinosinusitis, and asthma will facilitate early identification of asthma and improve patient outcomes.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171002
[Lr] Last revision date:171002
[St] Status:Publisher

  10 / 3323 MEDLINE  
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[PMID]: 28631682
[Au] Autor:Stepanova YE; Gotovyakhina TV; Korneenkov AA; Koren' EE
[Ad] Address:Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, Saint-Petersburg, Russia, 190013.
[Ti] Title:Kompleksnoe lechenie disfonii u lits golosorechevykh professii. [The combined treatment of dysphonia in the subjects engaged in the voice and speech professions].
[So] Source:Vestn Otorinolaringol;82(3):48-53, 2017.
[Is] ISSN:0042-4668
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The objective of the present study was to evaluate the effectiveness of the application of homeovox for the combined treatment of small vocal cord nodules and acute laryngitis in the professional voice users. A total of 40 subjects presenting with dysphonia were examined after they were divided into two study groups and two groups of comparison depending on the nosological form of the pathological condition. The subjects comprising the study groups were given traditional therapy in the combination with the intake of homeovox whereas the patients included in the two groups of comparison received the traditional treatment alone. The outcome of the treatment was evaluated on days 1, 5, and 10 after the initiation of therapy based on the analysis of the changes in the videoendostroboscopic picture of the larynx and the acoustic characteristics obtained by the computer-assisted analysis of the voice. The analysis of the results of the combined treatment has demonstrated the statistically significant differences in some acoustic parameters of the voice between the subjects with small vocal cord nodules and acute laryngitis belonging to the study groups and the groups of comparison. It is concluded that the introduction of homeovox in the combined treatment of the patients presenting with the small nodules in the vocal cords and acute catarrhal laryngitis accelerates the recovery of the acoustic characteristics of the voice within various periods after the onset of the treatment in comparison with the patients treated with the use of traditional therapy alone.
[Mh] MeSH terms primary: Dysphonia
Materia Medica/administration & dosage
Occupational Diseases
Voice Quality/drug effects
[Mh] MeSH terms secundary: Adult
Anti-Inflammatory Agents/administration & dosage
Drug Monitoring
Drug Therapy, Combination/methods
Dysphonia/diagnosis
Dysphonia/drug therapy
Dysphonia/etiology
Dysphonia/physiopathology
Expectorants/administration & dosage
Female
Humans
Laryngoscopy/methods
Male
Middle Aged
Occupational Diseases/diagnosis
Occupational Diseases/drug therapy
Occupational Diseases/etiology
Occupational Diseases/physiopathology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Anti-Inflammatory Agents); 0 (Expectorants); 0 (Materia Medica)
[Em] Entry month:1709
[Cu] Class update date: 170927
[Lr] Last revision date:170927
[Js] Journal subset:IM
[Da] Date of entry for processing:170620
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201782348-53


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