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[PMID]: 29454709
[Au] Autor:Ebo DG; Faber M; Elst J; Van Gasse AL; Bridts CH; Mertens C; De Clerck LS; Hagendorens MM; Sabato V
[Ad] Address:Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium. Electronic address: immuno@uantwerpen.be.
[Ti] Title:In Vitro Diagnosis of Immediate Drug Hypersensitivity During Anesthesia: A Review of the Literature.
[So] Source:J Allergy Clin Immunol Pract;, 2018 Feb 14.
[Is] ISSN:2213-2201
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Quantification of specific IgE (sIgE) antibodies constitutes an important measure to document anesthesia-related immediate hypersensitivity reactions (IHRs). However, only a few drug-specific assays are available and their predictive value is not known. In cases of non-IgE mediated IHRs, diagnosis might benefit from cellular tests such as basophil mediator release tests and basophil activation tests (BATs). To review the potential and limitations of quantification of sIgE, mediator release, and BAT in anesthesia-related IHRs, a literature search was conducted using the key words allergy, basophil activation, CD63, CD203c, diagnosis, drugs, hypersensitivity, flow cytometry, MRGPRX2, specific IgE antibodies, leukotrienes, histamine, and tryptase; this was complemented by the authors' experience. The drugs and compounds that have predominantly been studied are neuromuscular blocking agents (NMBAs), ß-lactams, latex, and chlorhexidine. For sIgE NMBA, sensitivity and specificity varies between 38.5% to 92% and 92% to 100%, respectively. For sIgE ß-lactams, sensitivity varies between 0% to 85% and specificity between 52% to 100%. sIgE to morphine should not be used in isolation to diagnose IHRs to NMBAs or opiates. sIgE for latex, and, in difficult cases, molecular diagnosis with quantification of sIgE to Hevea components constitute reliable diagnostics. For drugs, the sensitivity of BAT varies between 50% and 60% and specificity reaches 80% to 90%. Basophil mediator release tests seem to be abandoned and supplanted by BATs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher

  2 / 3285 MEDLINE  
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[PMID]: 29364614
[Au] Autor:Shumakova AA; Shipelin VA; Trushina EN; Mustaphina OK; Gmoshinsky IV; Khanferyan RA; Khotimchenko SA; Tutelyan VA
[Ti] Title:[Toxicological assessment of nanostructured silica. IV. Immunological and allergological indices in animals sensitized with food allergen and final discussioin].
[So] Source:Vopr Pitan;84(5):102-11, 2015.
[Is] ISSN:0042-8833
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:This paper is the final in a series of publications on the assessment of subacute oral toxicity of nanostructured silica (SiO2). Preparation studied was a commercial nanopowder of SiO2, obtained by hydrolysis of tetrachlorosilane in the gaseous phase with the size of primary nanoparticles (NPs) of 5­30 nm. The experiment was conducted in 95 male Wistar rats weighing 150­180 g, divided into 6 groups numbering 25 (group 1), 26 (group 2), 11 (groups 3­6) of animals. The aqueous dispersion of SiO2 after sonication was administered to animals of groups 2, 4 and 6 for 28 days by intragastric gavage at a dose of 100 mg/kg of body weight per day. Animals of groups 1, 3, and 5 were treated with deionized water. On the 1st, 3d, 5th and 21st day of experiment the rats of groups 1, 2, 3 and 4 were sensitized intraperitoneally with hen's egg ovalbumin (OVA) adsorbed to aluminum hydroxide. Intravenous administration of the challenge dose OVA to rats in groups 1 and 2 was carried out on the 29th day. In the same period animals of groups 3­6 were bled for analysis of cellular immunity. There were evaluated the severity of systemic anaphylaxis reaction, the level of specific IgG antibodies to OVA in sensitized animals, state of erythrocytes, platelets and leukocytes of peripheral blood using standard methods. Using flow cytometry there were measured contents of lymphocyte populations of B-lymphocytes (CD45RA+), total T-lymphocytes (CD3+), T-helper cells (CD4+), T-cytotoxic cells (CD8+), NKcells (CD161a+), phagocytic activity of polymorphonuclear leukocytes in respect of latex particles. Serum levels of TNFα and IL-10 cytokines were determined by ELISA. The result showed that NPs SiO2, at dose of 100 mg/kg body weight had no any marked effect on severity of active anaphylactic shock and level of specific antibodies. The changes in cellular immunity under the influence of nanomaterial had similar direction in sensitized and non-sensitized animals and were more pronounced in the latter. Based on the discussion of the results, together with data from previous publications it was concluded that oral maximum level without observable adverse effect (NOAEL) of nanostructured SiO2 is located below 100 mg/kg body weight.
[Mh] MeSH terms primary: Anaphylaxis/blood
Food Hypersensitivity/blood
Nanoparticles/adverse effects
Silicon Dioxide/adverse effects
[Mh] MeSH terms secundary: Anaphylaxis/pathology
Animals
B-Lymphocytes/metabolism
B-Lymphocytes/pathology
CD4-Positive T-Lymphocytes/metabolism
CD4-Positive T-Lymphocytes/pathology
CD8-Positive T-Lymphocytes/metabolism
CD8-Positive T-Lymphocytes/pathology
Food Hypersensitivity/pathology
Immunoglobulin G/blood
Interleukin-10/blood
Male
Rats
Rats, Wistar
Silicon Dioxide/pharmacology
Tumor Necrosis Factor-alpha/blood
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 7631-86-9 (Silicon Dioxide)
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:180125
[St] Status:MEDLINE

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[PMID]: 29383926
[Au] Autor:Gaspar-Marques J; Finelli E; Martins PC; Prates S; Leiria-Pinto P
[Ad] Address:Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisbon, Portugal; CEDOC, Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, Lisbon, Portugal.
[Ti] Title:Piperacillin-tazobactam anaphylaxis: a rare cause of occupational disease.
[So] Source:Eur Ann Allergy Clin Immunol;, 2017 Nov 20.
[Is] ISSN:1764-1489
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Summary: Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure. Skin prick tests (SPT) to beta-lactams were positive to piperacillin, penicillin G and major and minor determinants. SPT to cefuroxime was negative but intradermic test was positive. The patient has indication for beta-lactams eviction and for adrenaline auto-injector kit. No further reactions occurred after patient's transfer to another department with minimum possible exposure. Allergic risk prevention is essential and must be rapidly implemented to avoid incapacitating occupational diseases development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[St] Status:Publisher
[do] DOI:10.23822/EurAnnACI.1764-1489.29

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[PMID]: 29202900
[Au] Autor:Lopez MC
[Ad] Address:National Institute of Industrial Technology, Agrifoods Center, Buenos Aires, Argentina.
[Ti] Title:Food Allergen Labeling: A Latin American Approach.
[So] Source:J AOAC Int;101(1):14-16, 2018 Jan 01.
[Is] ISSN:1060-3271
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Food allergy is a public health concern almost all over the world. Although most of the countries that regulate the declaration of allergens in prepackaged foods include the list recommended by the Codex Alimentarius, some countries have added other allergens to this list due to prevalence data and regional incidence, whereas others have incorporated exceptions for some products derived from allergenic foods. Within this context, the situation in Latin America regarding these regulations is diverse. Data about prevalence of food hypersensitivity are very limited in the region. The countries that have established regulations are Brazil, Colombia, Costa Rica, Guatemala, Honduras, El Salvador, Nicaragua, Chile, Mexico, and Venezuela. Argentina has approved a regulation for the labeling of food allergens in November 2016. It only needs to be published in the Official Bulletin to go into effect. All countries follow the Codex list that includes latex and excludes sulfites, except Brazil. On the other hand, Argentina is the only country that includes exceptions. As for the methodologies for the detection of allergens in foods, this issue is a serious problem for both the food industry and control laboratories. Available methodologies are based mainly on commercial ELISA kits; currently, there are no Latin American companies that produce them, so ELISA kits are expensive and their acquisition is complicated. There is an initiative in Argentina to address all these gaps in the region through the Platform of Food Allergens (PFA), a nonprofit organization that integrates health professionals, patients, representatives of the food industry, government, and scientists. The different actions carried out by the PFA have made it possible to contact different scientific groups from other Latin American countries in order to expand this initiative and thereby promote and strengthen both public and private capacities in the region.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:In-Process
[do] DOI:10.5740/jaoacint.17-0382

  5 / 3285 MEDLINE  
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[PMID]: 29249105
[Au] Autor:Bedolla-Barajas M; Machuca-Rincón ML; Morales-Romero J; Macriz-Romero N; Madrigal-Beas IM; Robles-Figueroa M; Bedolla-Pulido TR; González-Mendoza T
[Ad] Address:Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Servicio de Alergia e Inmunología Clínica, Guadalajara, Jalisco, México. drmbedbar@gmail.com.
[Ti] Title:Prevalencia de autorreporte de alergia al látex y factores asociados en trabajadores de la salud. [Self-reported prevalence of latex allergy and associated factors in healthcare workers].
[So] Source:Rev Alerg Mex;64(4):430-438, 2017 Oct-Dec.
[Is] ISSN:0002-5151
[Cp] Country of publication:Mexico
[La] Language:spa
[Ab] Abstract:BACKGROUND: In our country, the prevalence of latex allergy in health personnel has rarely been studied. OBJECTIVE: To determine the prevalence and associated factors to self-reported latex allergy in health care workers. METHODS: A cross-sectional study was conducted among 1,292 health care workers of a second level hospital. All workers were included and they were required to answer a structured questionnaire aimed at identifying latex allergy, atopic personal and family history, exposure to latex gloves and surgical background. Odds ratio (OR) and 95 % confidence interval (95 % CI) were estimated using regression logistic to investigate factors associated to latex allergy. RESULTS: The female to male ratio was 2.4:1. The men age 38.4 ± 11.6 years. The prevalence of latex allergy auto-reported was 9.7 %, with a confidence interval of 95 % (95 % CI) 8.1 %-11.3 %. There was no statistical difference by workplace (p = 0.508). Factors associated with latex allergy included female gender (OR = 1.68; 95 % CI: 1.03-2.73, p = 0.037), personal history of atopy (OR = 4.82; 95 % CI: 3.19-7.26, p < 0.0001), family history of atopic dermatitis (OR = 4.33, 95 % CI: 1.20-4.41) and history of allergy to fruits (OR = 4.33; 95 % CI: 2.62-7.14, p < 0.0001). CONCLUSIONS: Up to 10 out to 100 health workers may have latex allergy. The main factors associated with latex allergy in this study were: being a female, personal or familiar atopy and allergy to fruits.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:In-Data-Review

  6 / 3285 MEDLINE  
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[PMID]: 28837242
[Au] Autor:Jankowski M; Kodyra E; Kaszubowska J; Czajkowski R
[Ad] Address:Chair of Dermatology, Sexually Transmitted Diseases and Imuunodermatology, Faculty of Medicine, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
[Ti] Title:Characterization of patients with suspected hypersensitivity to cervicovaginal fluid.
[So] Source:J Eur Acad Dermatol Venereol;, 2017 Aug 24.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergic reaction to seminal plasma was described decades ago. In USA, only tens of thousands women are estimated to be affected. Not only seminal plasma but also cervicovaginal fluid contains sex-restricted antigens, yet allergy to cervicovaginal fluid has never been reported in medical literature. We came to a suspicion that because immunologic tests required to prove such a diagnosis, allergy to cervicovaginal fluid has never been reported yet it is not uncommon. OBJECTIVE: The objective of this study was to use an Internet-based questionnaire to characterize the population of men with suspected hypersensitivity to cervicovaginal fluid. METHODS: A questionnaire designed to cover localized and systemic symptoms of hypersensitivity reaction was made available via the Internet. Respondents with postcoital adverse reactions were invited to participate. Only respondents who presented with at least two symptoms suggestive to hypersensitivity to seminal plasma or cervicovaginal fluid and were negative for STI, and known hypersensitivity reactions such as latex allergy were a subject for further analysis. Board-certified dermatologists were surveyed for seeing bona fide cases of cervicovaginal fluid hypersensitivity. RESULTS: We have identified 52 cases of suspected hypersensitivity to cervicovaginal fluid (CVF). Both localized and systemic types of hypersensitivity were identified. A substantial number of dermatologists admitted to witnessing cases of hypersensitivity to CVF. CONCLUSION: Based on data from affected individuals as well as the opinions of dermatologists worldwide, we believe that allergic reaction to cervicovaginal fluid is at least as common as seminal plasma allergy. However, remains unreported due to technical difficulties in diagnosis and dermatologists' disbelief in its actual existence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170912
[Lr] Last revision date:170912
[St] Status:Publisher
[do] DOI:10.1111/jdv.14550

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[PMID]: 28777679
[Au] Autor:Beierwaltes P; Schoessler S
[Ad] Address:Assistant Professor, Nursing, Minnesota, State University, Mankato.
[Ti] Title:Latex Safe at School: A Student-Centered Approach.
[So] Source:NASN Sch Nurse;32(6):343-345, 2017 Nov.
[Is] ISSN:1942-6038
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Providing a safe environment for students at risk for anaphylaxis from a latex allergy requires care coordination and collaboration of all members of the school community. Strategies for allergy management include educating the school community, identifying potential exposure to latex, preparing to respond in an emergency, and creating a plan for the future. With the student at the center of sound planning, the school can provide a secure and healthy environment.
[Mh] MeSH terms primary: Environmental Exposure/prevention & control
Latex Hypersensitivity/prevention & control
Nurse´s Role
Patient-Centered Care
[Mh] MeSH terms secundary: Child
Emergency Treatment
Humans
Latex Hypersensitivity/nursing
School Health Services
School Nursing
Students
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[Js] Journal subset:N
[Da] Date of entry for processing:170805
[St] Status:MEDLINE
[do] DOI:10.1177/1942602X17715495

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[PMID]: 28709944
[Au] Autor:Bezerra CF; Mota ÉF; Silva ACM; Tomé AR; Silva MZR; de Brito D; Porfírio CTMN; Oliveira AC; Lima-Filho JV; Ramos MV
[Ad] Address:Instituto Federal de Educação, Ciência e Tecnologia do Estado do Rio Grande do Norte, Pau dos Ferros, Rio Grande do Norte, Brazil. Electronic address: bfmila@yahoo.com.br.
[Ti] Title:Latex proteins from Calotropis procera: Toxicity and immunological tolerance revisited.
[So] Source:Chem Biol Interact;274:138-149, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Many thousands of plants are disseminated worldwide in traditional and folk medicines based on the belief that their leaves, roots, seeds, bark or secretions, when adequately handled, can treat, alleviate or ameliorate numerous disease symptoms. Calotropis procera (Apocynaceae) is a popular medicinal plant and the claims of this shrub's phytomedicinal properties have been scientifically validated. In this study, further prospects towards the in vivo toxicity and oral immunological tolerance of phytomodulatory proteins isolated from the latex of C. procera are reported. Acute toxicity was determined in mice by oral and intraperitoneal administration of latex proteins (LP) and was followed behavioral, hematological and histological analyses. Oral immunological tolerance to LP was assessed by intraperitoneal immunization in mice that had received LP orally before. Animals given 5000 mg/kg orally exhibited only discrete behavioral alterations and augmentation of monocytes. Death was not notified 14 days after exposure. However, all animals receiving LP 150 mg/kg by i.p. died in 1 h. Death (20%) was documented when LP (75 mg/kg) was given in the peritoneum and signs of harmful effects were observed in the survivors (80%). Oral immunological tolerance was observed in animals previously given LP orally, when they were further immunized/challenged with peritoneal exposure to different doses of LP. This was confirmed by the lowering of IgE and IgG in the serum, IL-4 and IFN-γ in spleen homogenates and the absence of anaphylaxis signs. It is therefore concluded that LP exhibited quite discrete adverse effects when orally administrated at higher concentrations and this route of administration did not stimulate adverse immunological reactions. Instead it was observed immunological tolerance. The present study contributes very important information concerning the safe use of C. procera as a phytotherapeutic agent.
[Mh] MeSH terms primary: Calotropis/metabolism
Immune Tolerance/drug effects
Latex/toxicity
Plant Proteins/toxicity
[Mh] MeSH terms secundary: Administration, Oral
Anaphylaxis/etiology
Animals
Female
Hypersensitivity, Delayed/etiology
Immunoglobulin E/blood
Immunoglobulin G/blood
Infusions, Parenteral
Interferon-gamma
Interleukin-4/metabolism
Kidney/drug effects
Kidney/pathology
Latex/immunology
Latex/metabolism
Mice
Plant Proteins/immunology
Plants, Medicinal/metabolism
Spleen/drug effects
Spleen/metabolism
Spleen/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G); 0 (Latex); 0 (Plant Proteins); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 82115-62-6 (Interferon-gamma)
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[Js] Journal subset:IM
[Da] Date of entry for processing:170716
[St] Status:MEDLINE

  9 / 3285 MEDLINE  
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[PMID]: 28653246
[Au] Autor:Caminati M; Giorgis V; Palterer B; Racca F; Salvottini C; Rossi O
[Ad] Address:Allergy Unit and Asthma Center, Verona University and General Hospital, Verona, Italy.
[Ti] Title:Allergy and Sexual Behaviours: an Update.
[So] Source:Clin Rev Allergy Immunol;, 2017 Jun 26.
[Is] ISSN:1559-0267
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients. Sexual behaviours may act as the triggers of allergic reactions or as the carriers of allergens. Food and drug allergens can be carried through human organic fluids, like saliva and semen. Latex in condoms and numerous substances in lubricants, spermicides, topical medications and cosmetics can cause allergic reactions or contact dermatitis. Sexual activity itself is also a potential trigger of symptoms in patients affected by respiratory allergies, like honeymoon asthma and rhinitis. In seminal plasma hypersensitivity, seminal fluid proteins are the culprit allergens. The present review aims at summarizing the state of the art about allergy and sexual behaviours. In clinical practice, the influence of common allergic diseases on the sexual quality of life should be taken carefully into account. Sexual behaviours need to be accounted in the differential diagnosis of hypersensitivity reactions, and awareness on those exposure routes should be raised between different specialists and general practitioners.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1706
[Cu] Class update date: 170627
[Lr] Last revision date:170627
[St] Status:Publisher
[do] DOI:10.1007/s12016-017-8618-3

  10 / 3285 MEDLINE  
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[PMID]: 28483312
[Au] Autor:Hsu Blatman KS; Hepner DL
[Ad] Address:Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, Mass. Electronic address: khsublatman@partners.org.
[Ti] Title:Current Knowledge and Management of Hypersensitivity to Perioperative Drugs and Radiocontrast Media.
[So] Source:J Allergy Clin Immunol Pract;5(3):587-592, 2017 May - Jun.
[Is] ISSN:2213-2201
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Perioperative anaphylaxis is an iatrogenic clinical condition, most often after anesthetic induction. Several mechanisms are implicated, including IgE- and non-IgE-mediated mechanisms. Perioperative anaphylaxis tends to be severe and has a higher mortality rate than anaphylaxis in other settings. This is partly due to factors that impair early recognition of anaphylaxis. Neuromuscular blocking agents, latex containing products, and antibiotics are the most common etiology. Chlorhexidine and dyes are increasingly culprits. The newest emerging cause is sugammadex, which is used for reversal of the effects of steroidal neuromusclar agents, such as rocuronium. Latex-induced allergy is becoming less common than in the 1980s due to primary and secondary prevention measures. Serum tryptase levels during the time of anaphylaxis and skin testing to suspected agents as an outpatient are necessary to confirm the diagnosis. Management includes epinephrine and aggressive fluid therapy. With radiocontrast media allergy, patients with a history of immediate hypersensitivity reactions to radiocontrast media should receive steroid and antihistamine premedication before re-exposure. Because IgE-mediated anaphylaxis to radiocontrast media is rare, there is a universal consensus that routinely skin testing all patients with a past reaction is not effective.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170509
[Lr] Last revision date:170509
[St] Status:In-Process


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