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[PMID]: 29518879
[Au] Autor:Zhang Y; Chang QL; Zhou Y; Hou ZJ; Li DM
[Ad] Address:Ophthalmology Hospital of Hebei, Xingtai 054001, China.
[Ti] Title:[Computed tomography imaging parameters of 82 Chinese patients with congenital microphthalmia].
[So] Source:Zhonghua Yan Ke Za Zhi;54(3):199-204, 2018 Mar 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To observe computed tomography (CT) imaging parameters of congenitally blind microphthalmia in Chinese patients and to provide clinical reference data for the Chinese population. It was a retrospective study for a consecutive case series of congenitally blind microphthalmia from July 2011 to July 2013. All of the patients were diagnosed in the Ocular Plastic Department, Tongren Eye Center, Beijing Tongren Hospital. We employed multi-section helical CT imaging with a computer-aided design system to observe and measure the imaging features in 82 Chinese patients (85 eyes). The paired T-test was applied for comparing the axial lengths, transverse diameters, and vertical diameters between the both sides in patients with congenital microphthalmia. The Pearson correlation was used for analyzing the relationship between the axial length and the age of the patients. In the 82 patients, the age ranged from 1 month to 40 years old. Forty-one patients were male and 41 were female. The disease was unilateral in 96.34% of the patients. The orbital cysts were observed in 12.94% of them, and 76.47% of them presented basic structures on the CT scan. The abnormalities of the lens (62.35% of the eyes) and vitreous (82.35% of the eyes) were observed. The mean maximum axial length of the affected eyes (85 eyes) was (14.52±0.56) mm and the mean axial length of the unaffected eyes (79 eyes) was (22.79±0.36) mm. There was significantly statistical difference in the ocular size between the affected and unaffected eyes ( 1.156, 0.001) . Congenitally blind microphthalmia is usually complicated with the abnormalities of the lens and vitreous. The ocular size decreases significantly. The results of the present study provide a clinical reference for evaluating congenitally blind microphthalmia. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2018.03.010

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[PMID]: 28471102
[Au] Autor:Yoo SG; Cho MJ; Kim US; Baek SH
[Ad] Address:Department of Ophthalmology, Kim's Eye Hospital, Seoul, Korea.
[Ti] Title:Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen.
[So] Source:Korean J Ophthalmol;31(3):249-256, 2017 Jun.
[Is] ISSN:2092-9382
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children. METHODS: The medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals. Regimen 2 was a cyclopentolate-only regimen comprising the administration of three to four drops of 1% cyclopentolate at 15-minute intervals. The mean difference between noncycloplegic and cycloplegic refraction was compared between the two regimens. RESULTS: A total of 308 eyes of 308 hyperopic children were included. The mean difference (±standard deviation) in the spherical equivalent (SE) between cycloplegic and noncycloplegic refraction was significantly larger in regimen 2 than in regimen 1, with values of +1.70 ± 1.03 diopters (D) and +1.25 ± 0.89 D, respectively (p=0.001). The SE change after cycloplegia was significantly different between the two regimens only in patients aged 5 years or younger (p=0.001), particularly in those with high hyperopia with an SE ≥5 D (p=0.005) or fully accommodative esotropia (p=0.009). There was no significant difference between the two regimens in patients older than 5 years, regardless of the presence of high hyperopia or fully accommodative esotropia. CONCLUSIONS: The Tropherine-added regimen exerted a weaker cycloplegic effect than the cyclopentolate-only regimen, particularly in children under the age of 5 years with high hyperopia or fully accommodative esotropia. However, the difference in refraction between the two regimens was small. A Tropherine-added regimen can be effective in hyperopic children, with less associated discomfort than the instillation of cyclopentolate.
[Mh] MeSH terms primary: Accommodation, Ocular/drug effects
Cyclopentolate/administration & dosage
Eye Diseases, Hereditary/drug therapy
Hyperopia/drug therapy
Phenylephrine/administration & dosage
Refraction, Ocular/drug effects
Tropicamide/administration & dosage
[Mh] MeSH terms secundary: Adolescent
Child
Child, Preschool
Drug Therapy, Combination
Eye Diseases, Hereditary/physiopathology
Female
Follow-Up Studies
Humans
Hyperopia/physiopathology
Infant
Infant, Newborn
Male
Mydriatics/administration & dosage
Ophthalmic Solutions/administration & dosage
Retrospective Studies
Time Factors
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); I76F4SHP7J (Cyclopentolate); N0A3Z5XTC6 (Tropicamide)
[Em] Entry month:1710
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0007

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[PMID]: 29495502
[Au] Autor:Paiva JS; Ribeiro RSR; Cunha JPS; Rosa CC; Jorge PAS
[Ad] Address:INESC TEC-INESC Technology and Science, 4200 Porto, Portugal. jipaiva@inesctec.pt.
[Ti] Title:Single Particle Differentiation through 2D Optical Fiber Trapping and Back-Scattered Signal Statistical Analysis: An Exploratory Approach.
[So] Source:Sensors (Basel);18(3), 2018 Feb 27.
[Is] ISSN:1424-8220
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Recent trends on microbiology point out the urge to develop optical micro-tools with multifunctionalities such as simultaneous manipulation and sensing. Considering that miniaturization has been recognized as one of the most important paradigms of emerging sensing biotechnologies, optical fiber tools, including Optical Fiber Tweezers (OFTs), are suitable candidates for developing multifunctional small sensors for Medicine and Biology. OFTs are flexible and versatile optotools based on fibers with one extremity patterned to form a micro-lens. These are able to focus laser beams and exert forces onto microparticles strong enough (piconewtons) to trap and manipulate them. In this paper, through an exploratory analysis of a 45 features set, including time and frequency-domain parameters of the back-scattered signal of particles trapped by a polymeric lens, we created a novel single feature able to differentiate synthetic particles (PMMA and Polystyrene) from living yeasts cells. This single statistical feature can be useful for the development of label-free hybrid optical fiber sensors with applications in infectious diseases detection or cells sorting. It can also contribute, by revealing the most significant information that can be extracted from the scattered signal, to the development of a simpler method for particles characterization (in terms of composition, heterogeneity degree) than existent technologies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  4 / 14039 MEDLINE  
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[PMID]: 29431939
[Au] Autor:Land D
[Ti] Title:Auditing ICD-10 Through the Lens of Education.
[So] Source:J AHIMA;87(10):82-3, 2016 10.
[Is] ISSN:1060-5487
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Clinical Coding
International Classification of Diseases
Medical Record Administrators/education
[Mh] MeSH terms secundary: Centers for Medicare and Medicaid Services (U.S.)
Humans
Management Audit
United States
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:H
[Da] Date of entry for processing:180213
[St] Status:MEDLINE

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[PMID]: 29492841
[Au] Autor:Gialletti R; Marchegiani A; Valeriani T; Nannarone S; Beccati F; Fruganti A; Laus F
[Ad] Address:Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126, Perugia, Italy.
[Ti] Title:A survey of ocular ultrasound abnormalities in horse: 145 cases.
[So] Source:J Ultrasound;, 2018 Feb 28.
[Is] ISSN:1876-7931
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:PURPOSE: To describe the association of clinical and ultrasonographic (US) findings in horses affected by visual impairments, to estimate the most frequent ultrasonographic alteration as well importance and limits of US as a part of ophthalmic evaluation in equine patients. METHODS: One-hundred-forty-five horses referred to the Veterinary Teaching Hospitals of the University of Perugia and Camerino for ocular problems were submitted to ophthalmic examination and ocular ultrasound. The following group of abnormalities was established: corneal alteration, cataract, synechiae, iris prolapse, anterior chamber alterations, vitreous opacities, globe reduction, globe enlargement, retinal detachment, lens subluxation/luxation, lens rupture, intraocular masses, retrobulbar masses. Specificity, sensitivity, positive and negative predictive value and related 95% confidence interval were calculated. Kappa value was estimated for concordance evaluation. RESULTS: A total of 384 clinical alterations were observed during ophthalmological examination, while 357 were found by ultrasound investigation. A very good agreement was found for lens subluxation/luxation, intraocular masses, iris prolapse, globe enlargement, lens rupture, vitreous opacities and cataract. Moderate agreement was found for retinal detachment, anterior chamber alterations and synechiae. Corneal alteration and globe reduction resulted in a fair and poor agreement, respectively. CONCLUSIONS: Ultrasonography affords the benefit of providing a complete cross-sectional view of the eyeball, facilitating the identification of ocular diseases in cases of loss of transparency of ocular media. It also represents an indispensable aid whenever anterior opacification precludes the use of ophthalmoscopic or biomicroscopic examination techniques.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1007/s40477-018-0284-7

  6 / 14039 MEDLINE  
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[PMID]: 28449695
[Au] Autor:Ness T; Boehringer D; Heinzelmann S
[Ad] Address:Eye Center, Medical Center, University of Freiburg, Faculty of Medicine, Killianstr. 5, 79106, Freiburg, Germany. thomas.ness@uniklinik-freiburg.de.
[Ti] Title:Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center.
[So] Source:Orphanet J Rare Dis;12(1):81, 2017 Apr 27.
[Is] ISSN:1750-1172
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Patients with intermediate uveitis (IU) represent a heterogenous group characterized by a wide spectrum of etiologies and regional differences. Aim of the study was to analyze the characteristics of patients with IU examined in an academic center in Germany. METHODS: We conducted a retrospective analysis of the clinical records of all patients with intermediate uveitis referred to the Eye Center, University of Freiburg from 2007 to 2014. Diagnosis followed the Standardization in Uveitis Nomenclature (SUN) criteria. Data analysis included: etiology of IU, demographics, complications, treatment and visual acuity. RESULTS: We identified 159 patients with intermediate uveitis during that period. Mean age at diagnosis was 35 years. Most are female (64%), and the mean duration of IU was 6.1 years (range 1 month - 35 years). Etiology of IU was idiopathic in 59%. Multiple sclerosis (MS) (20%) and sarcoidosis (10%) were frequent systemic causes of IU. Other etiologies including infectious diseases (tuberculosis, borreliosis) or immune-mediated conditions (eg, after vaccination) were present in 11%. The pattern of complications included macular edema (CME) (36%), cataract (24%), secondary glaucoma (7%), and epiretinal membrane formation (19%). Periphlebitis and optic neuritis were more frequent in conjunction with MS. Treatment comprised local and systemic steroids, immunosuppressive agents, biologics, and surgery. Best corrected visual acuity was better than 20/25 in 60% of the eyes after more than 10 years of follow-up. CONCLUSIONS: In our German academic center, most IU cases were idiopathic or associated with MS or sarcoidosis. In contrast to other countries, infectious cases were rare. Patients' overall visual prognosis is favorable even when the duration of IU has been long and and despite numerous complications.
[Mh] MeSH terms primary: Cataract/etiology
Glaucoma/etiology
Immunosuppressive Agents/therapeutic use
Multiple Sclerosis/complications
Sarcoidosis/complications
Uveitis, Intermediate
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Cataract/physiopathology
Child
Child, Preschool
Female
Glaucoma/physiopathology
Humans
Macular Edema/etiology
Macular Edema/physiopathology
Male
Middle Aged
Multiple Sclerosis/physiopathology
Retrospective Studies
Sarcoidosis/physiopathology
Steroids/therapeutic use
Treatment Outcome
Uveitis, Intermediate/complications
Uveitis, Intermediate/drug therapy
Uveitis, Intermediate/etiology
Uveitis, Intermediate/physiopathology
Visual Acuity/physiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunosuppressive Agents); 0 (Steroids)
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s13023-017-0638-9

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[PMID]: 29442498
[Au] Autor:Carver JA; Ecroyd H; Truscott RJW; Thorn DC; Holt C
[Ad] Address:Research School of Chemistry, The Australian National University , Acton, ACT 2601, Australia.
[Ti] Title:Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins.
[So] Source:Acc Chem Res;, 2018 Feb 14.
[Is] ISSN:1520-4898
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Molecular chaperone proteins perform a diversity of roles inside and outside the cell. One of the most important is the stabilization of misfolding proteins to prevent their aggregation, a process that is potentially detrimental to cell viability. Diseases such as Alzheimer's, Parkinson's, and cataract are characterized by the accumulation of protein aggregates. In vivo, many proteins are metastable and therefore under mild destabilizing conditions have an inherent tendency to misfold, aggregate, and hence lose functionality. As a result, protein levels are tightly regulated inside and outside the cell. Protein homeostasis, or proteostasis, describes the network of biological pathways that ensures the proteome remains folded and functional. Proteostasis is a major factor in maintaining cell, tissue, and organismal viability. We have extensively investigated the structure and function of intra- and extracellular molecular chaperones that operate in an ATP-independent manner to stabilize proteins and prevent their misfolding and subsequent aggregation into amorphous particles or highly ordered amyloid fibrils. These types of chaperones are therefore crucial in maintaining proteostasis under normal and stress (e.g., elevated temperature) conditions. Despite their lack of sequence similarity, they exhibit many common features, i.e., extensive structural disorder, dynamism, malleability, heterogeneity, oligomerization, and similar mechanisms of chaperone action. In this Account, we concentrate on the chaperone roles of α-crystallins and caseins, the predominant proteins in the eye lens and milk, respectively. Intracellularly, the principal ATP-independent chaperones are the small heat-shock proteins (sHsps). In vivo, sHsps are the first line of defense in preventing intracellular protein aggregation. The lens proteins αA- and αB-crystallin are sHsps. They play a crucial role in maintaining solubility of the crystallins (including themselves) with age and hence in lens proteostasis and, ultimately, lens transparency. As there is little metabolic activity and no protein turnover in the lens, crystallins are very long lived proteins. Lens proteostasis is therefore very different to that in normal, metabolically active cells. Crystallins undergo extensive post-translational modification (PTM), including deamidation, racemization, phosphorylation, and truncation, which can alter their stability. Despite this, the lens remains transparent for tens of years, implying that lens proteostasis is intimately integrated with crystallin PTMs. Many PTMs do not significantly alter crystallin stability, solubility, and functionality, which thereby facilitates lens transparency. In the long term, however, extensive accumulation of crystallin PTMs leads to large-scale crystallin aggregation, lens opacification, and cataract formation. Extracellularly, various ATP-independent molecular chaperones exist that exhibit sHsp-like structural and functional features. For example, caseins, the major milk proteins, exhibit chaperone ability by inhibiting the amorphous and amyloid fibrillar aggregation of a diversity of destabilized proteins. Caseins maintain proteostasis within milk by preventing deleterious casein amyloid fibril formation via incorporation of thousands of individual caseins into an amorphous structure known as the casein micelle. Hundreds of nanoclusters of calcium phosphate are sequestered within each casein micelle through interactions with short, highly phosphorylated casein sequences. This results in a stable biofluid that contains a high concentration of potentially amyloidogenic caseins and concentrations of calcium and phosphate that can be far in excess of the solubility of calcium phosphate. Casein micelle formation therefore performs vital roles in neonatal nutrition and calcium homeostasis in the mammary gland.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1021/acs.accounts.7b00250

  8 / 14039 MEDLINE  
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[PMID]: 29258513
[Au] Autor:Fiandaca MS; Mapstone M; Connors E; Jacobson M; Monuki ES; Malik S; Macciardi F; Federoff HJ
[Ad] Address:Department of Neurology, School of Medicine, Irvine, USA.
[Ti] Title:Systems healthcare: a holistic paradigm for tomorrow.
[So] Source:BMC Syst Biol;11(1):142, 2017 Dec 19.
[Is] ISSN:1752-0509
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural and man-made environment. Both extrinsic and intrinsic influences constantly challenge the biological networks associated with wellness. Such influences may dysregulate networks and allow pathobiology to evolve, resulting in early clinical presentation that requires astute assessment and timely intervention for successful mitigation. Herein, we describe the components of relevant biological systems and the nature of progression from at-risk to manifest disease. We illustrate the systems approach by examining two relevant clinical examples: Alzheimer's and cardiovascular diseases. The implications of systems healthcare management are examined through the lens of economics, ethics, policy and the law. Finally, we propose the need to develop new educational paradigms to enhance the training of the health professional in an era of systems medicine.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process
[do] DOI:10.1186/s12918-017-0521-2

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[PMID]: 29480245
[Au] Autor:Sridhar MS; Martin R
[Ad] Address:Department of Ophthalmology, Krishna Institute of Medical Sciences, Hyderabad, Telangana, India.
[Ti] Title:Anterior segment optical coherence tomography for evaluation of cornea and ocular surface.
[So] Source:Indian J Ophthalmol;66(3):367-372, 2018 Mar.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple. Several devices and technologies allow to explore and manage patients better. Optical coherence tomography (OCT) technology has evolved over the years, and hence a detailed evaluation of anterior segment (AS) structures such as cornea, conjunctiva, tear meniscus, anterior chamber, iris, and crystalline lens has been possible in a noncontact and safe procedure. The purpose of this special issue is to present and update in the evaluation of cornea and ocular surface, and this paper reviews a description of the AS-OCT, presenting the technology and common clinical uses of OCT in the management of diseases involving cornea and ocular surface to provide an updated information of the clinical recommendations of this technique in eye care practice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review
[do] DOI:10.4103/ijo.IJO_823_17

  10 / 14039 MEDLINE  
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[PMID]: 29461633
[Au] Autor:Baima JA; Silver JK; Most M
[Ad] Address:Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School.
[Ti] Title:Neuromuscular dysfunction in the cancer patient: Evaluation and treatment.
[So] Source:Muscle Nerve;, 2018 Feb 20.
[Is] ISSN:1097-4598
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cancer is a common diagnosis. In conjunction with various anti-neoplastic therapies delivered sequentially or concurrently, it makes oncology patients among the most complex to treat. This review uses a series of case studies to discuss the diagnosis and treatment of cancer-related nerve and muscle disorders. Oncologic treatment interventions such as surgery, chemotherapy, radiation therapy, and hormonal therapy, often have predictable side-effects, and sometimes their associated disability can be mitigated, especially if recognized early. Disease progression can mimic other diagnoses. The case studies provide a lens through which to study the presenting symptoms, differential diagnoses, diagnostic evaluation, and treatment interventions. These are all considered within the context of the patient's prognosis and health-related quality of life. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1002/mus.26103


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