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[PMID]: 29421593
[Au] Autor:Tang HH; Li HL; Li YX; You Y; Guan YY; Zhang SL; Liu LX; Bao WL; Zhou Y; Shen XY
[Ad] Address:Department of Pharmacology, School of Pharmacy, Fudan University, No. 826, Zhangheng Road, Pudong New Area, Shanghai 201203, China; Department of Pharmacology, School of Pharmacy, Guilin Medical University, No. 109 Huanchengbei Road Two, Guilin 541004, China.
[Ti] Title:Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-κB and Nrf2 signaling pathways.
[So] Source:J Ethnopharmacol;217:118-125, 2018 Feb 05.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Jiang-Xian HuGan (JXHG) formulated by five natural products including Freshwater clam (Corbicula fluminea), Curcuma longa L., Ligustrum lucidum, Eclipta prostrata (L.) L. and Paeonia lactiflora Pall., has exhibited a great hepatoprotective effect. AIM OF THIS STUDY: We investigated the effect of JXHG on concanavalin A (ConA)-induced acute live injury in mice, and to elucidate its underlying molecular mechanisms. MATERIALS AND METHODS: Jiangkanling Capsule (900 mg/kg), low-dose JXHG (LJXHG, 700 mg/kg), high-dose JXHG (HJXHG, 1400 mg/kg) were administered to mice by oral gavage daily for 20 days prior to a single intravenous injection of ConA (20 mg/kg). Liver injury was evaluated by measuring the serum levels of enzymes and cytokines as well as liver histological analysis. We also measured the hepatic expression of cytokines at mRNA levels and the proteins related to NF-κB and Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathways. RESULT: Our results showed that JXHG pretreatment significantly alleviated ConA-induced live injury as evidenced by decreased serum levels of glutamic-pyruvic transaminase (ALT) and glutamic oxalacetic transaminase (AST), and reduced hepatocyte apoptosis and mortality. Furthermore, JXHG was able to significantly reduce the serum levels of proinflammatory cytokines, down-regulate the mRNA expression of interleukin-6 (IL-6) and interferon-γ (IFN-γ), and up-regulate IL-10 as well as superoxide-dimutase-1 (SOD1), glutathione reductase (GSR) and Glutathione peroxidase 2 (GPX2) mRNA in the liver tissues after Con A injection. In addition, JXHG pretreatment dramatically suppressed the phosphorylation of NF-κB p65 (p65), increased Nrf2 expression, and decreased the expression ratio of cleaved caspase-3/caspase-3 in liver tissues. CONCLUSION: These results suggest that JXHG protects against ConA-induced acute live injury through inhibiting NF-κB mediated inflammatory pathway and promoting Nrf2 mediated anti-oxidative stress signaling pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

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[PMID]: 29468762
[Au] Autor:Yang R; Chu X; Sun L; Kang Z; Ji M; Yu Y; Liu Y; He Z; Gao N
[Ad] Address:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education; Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China.
[Ti] Title:Hypolipidemic activity and mechanisms of the total phenylpropanoid glycosides from Ligustrum robustum (Roxb.) Blume by AMPK-SREBP-1c pathway in hamsters fed a high-fat diet.
[So] Source:Phytother Res;, 2018 Feb 22.
[Is] ISSN:1099-1573
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this study was to evaluate the hypolipidemic effect and mechanisms of total phenylpropanoid glycosides extracted from Ligustrum robustum (Roxb.) Blume (LRTPG) in hamsters fed a high-fat diet and to discover bioactive components in HepG2 cell model induced by oleic acid. LRTPG of high (1.2g/kg), medium (0.6g/kg), and low (0.3g/kg) doses was administrated daily for 21 consecutive days in hamsters. We found that in hamsters fed a high-fat diet, LRTPG effectively reduced the concentrations of plasma triglycerides (TG), free fatty acid, total cholesterol, low-density lipoprotein cholesterol, and hepatic TG and total cholesterol. And the compounds acteoside, ligupurpuroside A, ligupurpuroside C, and ligupurpuroside D significantly inhibited lipid accumulation in HepG2 cell at the concentration of 50mol/L. Mechanism research demonstrated that LRTPG increased the levels of phospho-AMP-activated protein kinase and phospho-sterol regulatory element binding protein-1c in liver, further to suppress the downstream lipogenic genes as stearoyl-CoA desaturase 1, glycerol-3-phosphate acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 2, and diacylglycerol acyltransferase 2. In addition, LRTPG increased the hydrolysis of circulating TG by up-regulating lipoprotein lipase activities. These results indicate that LRTPG prevents hyperlipidemia via activation of hepatic AMP-activated protein kinase-sterol regulatory element binding protein-1c pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1002/ptr.6023

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[PMID]: 29311515
[Au] Autor:Suh WS; Kwon OK; Lee TH; Subedi L; Kim SY; Lee KR
[Ad] Address:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
[Ti] Title:Secoiridoid Glycosides from the Twigs of Ligustrum obtusifolium Possess Anti-inflammatory and Neuroprotective Effects.
[So] Source:Chem Pharm Bull (Tokyo);66(1):78-83, 2018.
[Is] ISSN:1347-5223
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Two new secoiridoid glycosides, obtusifolisides A and B (1, 2), together with 7 known secoiridoid glycosides (3-9) were isolated from the twigs of Ligustrum obtusifolium. The chemical structures of new compounds were determined by a spectroscopic data analysis, including one and two dimensional (1D-, 2D)-NMR, High resolution-MS, and experiments involving chemical reactions. The isolated secoiridoid glycosides were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated BV-2 murine microglia cells. Compounds 2, 5, 6, 8, and 9 significantly reduced the production of nitric oxide (NO), with IC values of 5.45, 11.17, 14.62, 15.45, and 14.96 M, respectively. None of the compounds were toxic to the cells. Additionally, we evaluated the neuroprotective effects of compounds 1-9 on nerve growth factor (NGF) induction in a C6 rat glioma cell line. Compounds 2 and 6 upregulated NGF secretion to 155.567.16%, and 139.3511.65%, respectively, without significant cell toxicity.
[Mh] MeSH terms primary: Anti-Inflammatory Agents, Non-Steroidal/pharmacology
Iridoid Glycosides/pharmacology
Ligustrum/chemistry
Neuroprotective Agents/pharmacology
Plant Stems/chemistry
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents, Non-Steroidal/chemistry
Anti-Inflammatory Agents, Non-Steroidal/isolation & purification
Cell Line
Cell Survival/drug effects
Dose-Response Relationship, Drug
Glioma/drug therapy
Glioma/metabolism
Iridoid Glycosides/chemistry
Iridoid Glycosides/isolation & purification
Lipopolysaccharides/antagonists & inhibitors
Lipopolysaccharides/pharmacology
Mice
Microglia/drug effects
Microglia/metabolism
Molecular Conformation
Nerve Growth Factors/antagonists & inhibitors
Nerve Growth Factors/metabolism
Neuroprotective Agents/chemistry
Neuroprotective Agents/isolation & purification
Nitric Oxide/antagonists & inhibitors
Nitric Oxide/biosynthesis
Rats
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Iridoid Glycosides); 0 (Lipopolysaccharides); 0 (Nerve Growth Factors); 0 (Neuroprotective Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00720

  4 / 290 MEDLINE  
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[PMID]: 29199255
[Au] Autor:Tanahashi T
[Ad] Address:Kobe Pharmaceutical University.
[Ti] Title:[Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts].
[So] Source:Yakugaku Zasshi;137(12):1443-1482, 2017.
[Is] ISSN:1347-5231
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens.
[Mh] MeSH terms primary: Alkaloids/isolation & purification
Glycosides/isolation & purification
Lichens/metabolism
Plants, Medicinal/metabolism
[Mh] MeSH terms secundary: Alangiaceae/metabolism
Alkaloids/biosynthesis
Alkaloids/chemistry
Benzylisoquinolines
Cephaelis/metabolism
Eschscholzia/metabolism
Glycosides/biosynthesis
Glycosides/chemistry
Iridoids
Monoterpenes
Oleaceae/metabolism
Rubiaceae/metabolism
Stephania/metabolism
Tetrahydroisoquinolines
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E (1,2,3,4-tetrahydroisoquinoline)
[Em] Entry month:1801
[Cu] Class update date: 180112
[Lr] Last revision date:180112
[Js] Journal subset:IM
[Da] Date of entry for processing:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00147

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[PMID]: 29177970
[Au] Autor:Yu BT; Hu Y; Ding YM; Tian JX; Mo JC
[Ad] Address:Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang Province, 310058, China.
[Ti] Title:Feeding on different attractive flowering plants affects the energy reserves of Culex pipiens pallens adults.
[So] Source:Parasitol Res;117(1):67-73, 2018 Jan.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Mosquito adults usually need to ingest sugar from nectar host plants to sustain their metabolic needs. Mosquitoes could be differentially attracted by various flowering plant species, and the volatiles were thought to be important factors attributed to the differential attractiveness. However, whether mosquitoes' preference for host plants correlates with their nutritional rewards from sugar sources remains unclear. In the present study, the preference of newly emerged Culex pipiens pallens to three kinds of flowering plants (Ligustrum quihoui, Abelia chinensis, and Nerium indicum) was determined in the olfactometer. Besides, when the newly emerged mosquitoes were provided with these flowering plants as sugar sources, the content of their metabolic reserves (glycogen, lipid, and protein) was determined. The results revealed that Cx. pipiens pallens could be differentially attracted by the odors emitted by the inflorescences of the tested flowering plants, and the nutritional rewards of mosquitoes were significantly affected by feeding on different inflorescences. The present study demonstrated that feeding on nectar host plants with differential attraction could affect the energy reserves of Cx. pipiens pallens.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:In-Process
[do] DOI:10.1007/s00436-017-5664-y

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[PMID]: 29214546
[Au] Autor:Marsaro AL; Panizzi AR; Lucini T
[Ad] Address:Lab of Entomology, Embrapa National Wheat Research Center, P.O. Box 3081, Passo Fundo, RS, 99001-970, Brasil.
[Ti] Title:Biology of a Neotropical Harlequin Stink Bug, Runibia perspicua (F.).
[So] Source:Neotrop Entomol;, 2017 Dec 07.
[Is] ISSN:1678-8052
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Laboratory and field studies were conducted with nymphs and adults of the Neotropical stink bug Runibia perspicua (F.) to evaluate their biology on plants. Total nymph mortality was ca. 13% on immature fruits of Brunfelsia australis Benth. (IFBA) and 90% on raw shelled peanuts, Arachis hypogaea L. (RSP); no nymphs survived on immature pods of green bean, Phaseolus vulgaris L., or on immature fruits of privet, Ligustrum lucidum Ait. Nymph developmental time was ca. 36 on IFBA and 55days on RSP. Body weight was significantly greater when nymphs were raised isolated compared to those raised in groups. Adult feeding activity was greater than third instars on IFBA. Adult longevity on IFBA + cherry tomato, Solanum lycopersicum L. fruit, reached ca. 150days. On IFBA, fecundity was 2.5 egg masses/female and 48.3 eggs/female; 25.6% of the eggs hatched. Adults did not reproduce on tomato. Body weight gain did not increase significantly for both sexes during the first four weeks of adult life on IFBA. In the field, plants of B. australis were surveyed in Passo Fundo, RS (2815'S; 5224'W). The majority of egg masses were deposited on the lower (abaxial) surface of leaves. Nymphs aggregated on immature fruits, and adults were seldom found on the plants. These are the first data on the performance of R. perspicua on B. australis indicating that this plant species is suitable to the bug's biology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171207
[Lr] Last revision date:171207
[St] Status:Publisher
[do] DOI:10.1007/s13744-017-0572-5

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[PMID]: 29134522
[Au] Autor:Sun X; Li H; Guo X; Sun Y; Li S
[Ad] Address:College of Landscape Architecture and Forestry, Qingdao Agriculture University, Qingdao, 266109, China.
[Ti] Title:Capacity of six shrub species to retain atmospheric particulates with different diameters.
[So] Source:Environ Sci Pollut Res Int;, 2017 Nov 13.
[Is] ISSN:1614-7499
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Garden plants can absorb and retain atmospheric particles and are important for remediating environmental pollution. In this study, the dust retention characteristics of six typical shrub species were measured in the greenbelt of a road in the Chengyang District of Qingdao, China, and the maximum capacity for dust retention of each species was determined. The different diameters and areas occupied by particulate matter (PM) were analyzed on the leaf surfaces of the plants. Based on the results for the six shrub species, the rank order of average content of dust retention per unit leaf area was Euonymus japonicus > Pyracantha fortuneana > Ligustrum vicaryi > Amygdalus triloba > Ligustrum sinense > Forsythia suspensa, whereas the rank order of average content per unit volume was E. japonicus > A. triloba > P. fortuneana > L. vicaryi > L. sinense > F. suspensa. The maximum content of dust retention per unit leaf area was reached in approximately 24days. Plants retained atmospheric PM primarily on the upper leaf surfaces. The primary portion of particles on the leaves was PM (over 80%), and PM was the principal component of PM . Leaf surface structure significantly affected the abilities of plants to retain PM, and the plants with a thick wax layer or large and dense stomata adsorbed more PM, such as E. japonicus. This study provides a scientific basis for the capacity of landscape plants to retain different diameter particulates.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:Publisher
[do] DOI:10.1007/s11356-017-0549-2

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[PMID]: 29127872
[Au] Autor:Tavera Busso I; Tames F; Silva JA; Ramos S; Homem V; Ratola N; Carreras H
[Ad] Address:Instituto Multidisciplinario de Biologa Vegetal, CONICET and Chemistry Department, FCEFyN, Universidad Nacional de Cordoba, Av. Velez Sarsfield, 1611, X5016 GCA Cordoba, Argentina.
[Ti] Title:Biomonitoring levels and trends of PAHs and synthetic musks associated with land use in urban environments.
[So] Source:Sci Total Environ;618:93-100, 2017 Nov 08.
[Is] ISSN:1879-1026
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Polycyclic aromatic hydrocarbons (PAHs) are some of the most studied organic compounds in urban environments, due to their known adverse effects on human health and persistence in environmental matrices. During the last decade, new groups of organic compounds with an intensive use worldwide such as synthetic musks have been raising the interest of the scientific community given their toxicity and health effects. However, literature is still scarce in studies dealing with their concentration in the environment, especially in developing countries, where they are even more rare or non-existing at all. We employed leaves of Ligustrum lucidum to assess the concentrations of PAHs and synthetic musks in different land use areas in Cordoba city, therefore contributing with environmental information in Argentina. We found higher levels of PAHs in urban and industrial areas than in the peri-urban sampling sites, naphthalene being one of the dominant PAHs in all sampling areas. Regarding synthetic musk fragrances, polycyclic musks were the most contributing compounds and the highest levels found in industrial areas as well. A high environmental risk could be expected due to the frequent occurrence of galaxolide in addition to the high hazardous potential of phantolide, which was present in 50% of the samples. The results of the present study indicate that leaves of an urban ubiquitous tree can be used to assess the spatial behavior of both "classic" and "emerging" organic pollutants, allowing an assessment of urban air quality in areas where common air sampling devices are unavailable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171111
[Lr] Last revision date:171111
[St] Status:Publisher

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[PMID]: 29086873
[Au] Autor:Yin Z; Zhang W; Zhang J; Kang W
[Ad] Address:Huanghe Science and Technology College, Zhengzhou, 450063, China.
[Ti] Title:Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers.
[So] Source:Chem Cent J;11(1):98, 2017 Oct 04.
[Is] ISSN:1752-153X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot water extraction and ethanol precipitation, and preliminarily purified by Sevage method and D101 macroporous resin. Then the polysaccharide was further purified by DEAE-52 cellulose and Sephadex G-100 column chromatography, respectively. The structural characteristics were detected by LC, GC, FT-IR and NMR. Furthermore, the coagulatory activity of the polysaccharides were investigated by APTT, TT, PT and FIB assays in vitro. The results demonstrated that four polysaccharides were isolated from flowers of L. lucidum, named as LLP-1a, LLP-1b, LLP-2 and LLP-3, and the yields were 0.039, 0.0054, 0.0055 and 0.017%, respectively based on the weight of the dried flowers. The four polysaccharides components were free of nucleic acids and proteins, and their average molecular weights were 25,912, 64,919, 3,940,246 and 2,975,091g/mol, respectively. The monosaccharide compositions of LLp-1a were L-rhamnose, L-arabinose, D-xylose, D-glucose andD-galactose (molar ratio of 3.16: 2.46:1.00: 7.27:4.22). Only D-galactose was detected from LLp-1b. LLp-2 was composed of L-arabinose, D-glucose and D-galactose (molar ratio of 1.28:1.32:1.00). LLp-3 was composed of L-rhamnose, L-arabinose, D-xylose, D-glucose and D-galactose (molar ratio of 5.85: 2.21: 2.23:1.00:2.25). Coagulation assays indicated that LLp-1a and LLp-3 had good anticoagulant effect in vitro, while LLp-1b showed procoagulant activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s13065-017-0332-y

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[PMID]: 29053368
[Au] Autor:Zeng P; Guo Z; Cao X; Xiao X; Liu Y; Shi L
[Ad] Address:a Institute of Environmental Engineering , School of Metallurgy and Environment, Central South University , Changsha 410083 , China.
[Ti] Title:Phytostabilization potential of ornamental plants grown in soil contaminated with cadmium.
[So] Source:Int J Phytoremediation;:0, 2017 Oct 20.
[Is] ISSN:1549-7879
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In a greenhouse experiment, five ornamental plants, Osmanthus fragrans (OF), Ligustrum vicaryi L. (LV), Cinnamomum camphora (CC), Loropetalum chinense var. rubrum (LC), and Euonymus japonicas cv. Aureo-mar (EJ), were studied for the ability to phytostabilization for Cd-contaminated soil. The results showed that these five ornamental plants can grow normally when the soil Cd content is less than 24.6 mgkg . Cd was mainly deposited in the roots of OF, LV, LC and EJ which have grown in Cd-contaminated soils, and the maximum Cd contents reached 15.76, 19.09, 20.59 and 32.91 mgkg , respectively. For CC, Cd was mainly distributed in the shoots and the maximum Cd content in stems and leaves were 12.5 and 10.71 mgkg , however, the total amount of Cd in stems and leaves was similar with the other ornamental plants. The enzymatic activities in Cd-contaminated soil were benefited from the five tested ornamental plants remediation. Soil urease and sucrase activities were improved, while dehydrogenase activity was depressed. Meanwhile, the soil microbial community was slightly influenced when soil Cd content is less than 24.6 mgkg under five ornamental plants remediation. The results further suggested that ornamental plants could be promising candidates for phytostabilization of Cd-contaminated soil.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:Publisher
[do] DOI:10.1080/15226514.2017.1381939


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