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[PMID]: 24486033
[Au] Autor:Nickenig HJ; Wichmann M; Zöller JE; Eitner S
[Ad] Address:Department of Oral, Maxillary and Plastic Facial Surgery and Interdisciplinary Department of Oral Surgery and Implantology (Head: Prof. Dr. Dr. J.E. Zöller), University of Cologne, Kerpener Str. 62, G-50937 Cologne, Germany. Electronic address: Dr.A.Nickenig@t-online.de....
[Ti] Title:3-D based minimally invasive one-stage lateral sinus elevation - a prospective randomized clinical pilot study with blinded assessment of postoperative visible facial soft tissue volume changes.
[So] Source:J Craniomaxillofac Surg;42(6):890-5, 2014 Sep.
[Is] ISSN:1878-4119
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The purpose of this prospective and randomized clinical study was to assess differences in patient morbidity between minimally invasive lateral sinus elevation (study group, n = 14) and conventional one-stage lateral sinus elevation (control group, n = 12). It was hypothesized that trauma to soft tissue was reduced in the study group. MATERIALS AND METHODS: Optical 3-D imaging was assessed blinded on days 1 and 7 after surgery to determine the visible soft tissue swelling of the upper lip and cheeks. Postoperative pain and discomfort were evaluated by a visual analogue scale (VAS; scale 0-10). RESULTS: Immediately and on day 1 after surgery, the study group patients rated pain and discomfort as 2.4 [SD 1.7] and 3.1 [SD 2.1], respectively, on the VAS; while, the controls rated 4 [SD 1.6] and 5.6 [SD 1.7], respectively. The mean facial soft tissue volume change, assessed on day 1 after surgery, was 5.0 cm(3) [range: 0.2-9.2] for the study group and 15.5 cm(3) (9.3-21.55) for the controls (p = 0.00). CONCLUSIONS: Despite the small number of patients in this prospective study, 3-D based minimally invasive one-stage lateral sinus elevation resulted in favourable patient morbidity with less postoperative visible facial soft tissue volume changes.
[Mh] MeSH terms primary: Cheek/pathology
Edema/prevention & control
Imaging, Three-Dimensional/methods
Lip Diseases/prevention & control
Postoperative Complications/prevention & control
Sinus Floor Augmentation/methods
[Mh] MeSH terms secundary: Adult
Cone-Beam Computed Tomography/methods
Dental Implantation, Endosseous/instrumentation
Dental Implantation, Endosseous/methods
Edema/pathology
Follow-Up Studies
Humans
Lip Diseases/pathology
Maxilla/surgery
Middle Aged
Minimally Invasive Surgical Procedures/methods
Optical Imaging/methods
Pain Measurement/methods
Pain, Postoperative/prevention & control
Patient Care Planning
Piezosurgery/methods
Pilot Projects
Prospective Studies
Single-Blind Method
User-Computer Interface
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1506
[Js] Journal subset:D; IM
[Da] Date of entry for processing:140809
[St] Status:MEDLINE

  2 / 5670 MEDLINE  
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[PMID]: 25472840
[Au] Autor:Balasubramanian R; Choi JH; Francescatto L; Willer J; Horton ER; Asimacopoulos EP; Stankovic KM; Plummer L; Buck CL; Quinton R; Nebesio TD; Mericq V; Merino PM; Meyer BF; Monies D; Gusella JF; Al Tassan N; Katsanis N; Crowley WF
[Ad] Address:Harvard Reproductive Endocrine Sciences Center & Reproductive Endocrine Unit of the Department of Medicine, and Medicine....
[Ti] Title:Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency.
[So] Source:Proc Natl Acad Sci U S A;111(50):17953-8, 2014 Dec 16.
[Is] ISSN:1091-6490
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it is unclear if these alleles are relevant to causality or overall genetic burden of Kallmann syndrome (KS) and normosmic form of IGD. To address this question, we sequenced CHD7 in 783 well-phenotyped IGD patients lacking full CHARGE features; we identified nonsynonymous rare sequence variants in 5.2% of the IGD cohort (73% missense and 27% splice variants). Functional analyses in zebrafish using a surrogate otolith assay of a representative set of these CHD7 alleles showed that rare sequence variants observed in controls showed no altered function. In contrast, 75% of the IGD-associated alleles were deleterious and resulted in both KS and normosmic IGD. In two families, pathogenic mutations in CHD7 coexisted with mutations in other known IGD genes. Taken together, our data suggest that rare deleterious CHD7 alleles contribute to the mutational burden of patients with both KS and normosmic forms of IGD in the absence of full CHARGE syndrome. These findings (i) implicate a unique role or preferential sensitivity for CHD7 in the ontogeny of GnRH neurons, (ii) reiterate the emerging genetic complexity of this family of IGD disorders, and (iii) demonstrate how the coordinated use of well-phenotyped cohorts, families, and functional studies can inform genetic architecture and provide insights into the developmental biology of cellular systems.
[Mh] MeSH terms primary: DNA Helicases/genetics
DNA-Binding Proteins/genetics
Deficiency Diseases/genetics
Gonadotropin-Releasing Hormone/deficiency
Kallmann Syndrome/genetics
Phenotype
Zebrafish/genetics
[Mh] MeSH terms secundary: Animals
Base Sequence
CHARGE Syndrome/genetics
CHARGE Syndrome/pathology
DNA Helicases/metabolism
DNA-Binding Proteins/metabolism
Gene Knockdown Techniques
Gonadotropin-Releasing Hormone/genetics
Humans
Molecular Sequence Data
Mutation, Missense/genetics
Otolithic Membrane/pathology
Protein Structure, Tertiary
Sequence Analysis, DNA
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (DNA-Binding Proteins); 33515-09-2 (Gonadotropin-Releasing Hormone); EC 3.6.4.- (DNA Helicases); EC 3.6.4.12 (CHD7 protein, human)
[Em] Entry month:1504
[Cu] Class update date: 150617
[Lr] Last revision date:150617
[Js] Journal subset:IM
[Da] Date of entry for processing:141217
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1417438111

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[PMID]: 15995759
[Au] Autor:Qiu WL; Lü Y; Chen WT
[Ad] Address:Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University. Shanghai 200011, China. qwl@omschina.org.cn
[Ti] Title:[Strengthen the scientific research on oral hereditary diseases].
[So] Source:Shanghai Kou Qiang Yi Xue;14(3):205-9, 2005 Jun.
[Is] ISSN:1006-7248
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:There are many kinds of oral hereditary diseases. Although some attempts have been tried to find the genetics of those diseases, still fewer information are available than the other hereditary diseases at present. Much is needed to do in the future. This article reviewed some cutting-edge findings on the genetics of several oral hereditary diseases including hereditary diseases involving the teeth, periodontal tissues, soft and hard tissues of the oral and maxillofacial region, as well as cleft lip and palate.
[Mh] MeSH terms primary: Cleft Lip
Cleft Palate
Maxillofacial Abnormalities/genetics
[Mh] MeSH terms secundary: Cleft Lip/genetics
Cleft Palate/genetics
Female
Humans
Male
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:D; IM
[Da] Date of entry for processing:050704
[St] Status:MEDLINE

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[PMID]: 24406633
[Au] Autor:Chu HW; Li JM; Chen GF; Ma JY
[Ad] Address:Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China....
[Ti] Title:Oral malignant acanthosis nigricans associated with endometrial adenocarcinoma.
[So] Source:Int J Oral Sci;6(4):247-9, 2014 Dec.
[Is] ISSN:1674-2818
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:We report a 59-year-old patient with malignant acanthosis nigricans associated with metastasis of endometrial carcinoma. The patient presented papillomatosis lesions that appeared to be benign on multiple skins of body folds, particularly on lips. The lesions in lips and axilla had histological characteristic appearances of acanthosis nigricans, while the masses in abdomen and pelvis were metastasis endometrial adenocarcinoma. The article highlights the importance of biopsy and histopathological diagnosis in presumed benign lesions and the role of doctors in screening for body internal tumors.
[Mh] MeSH terms primary: Acanthosis Nigricans/pathology
Adenocarcinoma/secondary
Endometrial Neoplasms/pathology
Lip Diseases/pathology
[Mh] MeSH terms secundary: Abdominal Neoplasms/secondary
Female
Follow-Up Studies
Humans
Lymphatic Metastasis/pathology
Middle Aged
Paraneoplastic Syndromes/pathology
Pelvic Neoplasms/secondary
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:D; IM
[Da] Date of entry for processing:141204
[St] Status:MEDLINE
[do] DOI:10.1038/ijos.2014.1

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[PMID]: 25616597
[Au] Autor:Vachirayonsti T; Ho KW; Yang D; Yan B
[Ad] Address:Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, Rhode Island 02881....
[Ti] Title:Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.
[So] Source:Toxicol Sci;144(2):382-92, 2015 Apr.
[Is] ISSN:1096-0929
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Endoplasmic reticulum (ER) stress is recognized as a common theme in the development of metabolic syndrome and other diseases. Chronic liver diseases develop ER stress and also show decreased capacity of drug metabolism. The pregnane X receptor (PXR) is a master regulator of genes involved in drug elimination. This study was performed to determine whether ER stress condition decreases the expression of PXR and whether the decrease alters the induction of cytochrome P450 3A4 (CYP3A4). Human primary hepatocytes and HepG2 cell line (human hepatocellular carcinoma) were treated with brefeldin A and thapsigargin, 2 well-established ER stressors. Without exceptions, both stressors significantly decreased the expression of PXR. The decrease led to reduced induction of CYP3A4. Reporter dissection study, electrophoretic mobility shift assay, and chromatin immunoprecipitation located in the PXR promoter region 2 adjacent elements recognized by hepatocyte nuclear factor-4α (HNF-4α) and cytidine-cytidine-adenosine-adenosine-thymidine enhanced binding proteins (C/EBPs), respectively. Additional studies demonstrated that HNF-4α was down-regulated during ER stress but the expression of C/EBPß varied depending on a particular form of C/EBPß. Liver-enriched activator protein (LAP) was down-regulated but liver-enriched inhibitory protein (LIP) was highly induced. Nevertheless, over-expression of HNF-4α or LAP restored the expression of PXR. Interestingly, the very same sequence also responded to interleukin-6 (IL-6), and primary hepatocytes treated with thapsigargin significantly increased the level of IL-6 mRNA. These findings establish a functional interconnection between ER stress and signaling of proinflammatory cytokines in the regulation of PXR expression.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1503
[Cu] Class update date: 150615
[Lr] Last revision date:150615
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1093/toxsci/kfv008

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[PMID]: 25888327
[Au] Autor:Oyetola EO; Owotade FJ; Agbelusi GA; Fatusi OA; Sanusi AA
[Ad] Address:Department of Preventive and Community Dentistry, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Osun State, Nigeria. Phemyhoye12@yahoo.com....
[Ti] Title:Oral findings in chronic kidney disease: implications for management in developing countries.
[So] Source:BMC Oral Health;15:24, 2015.
[Is] ISSN:1472-6831
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The importance of oral health care in the management of patients with systemic diseases including chronic kidney disease (CKD) has been affirmed. Many CKD patients have related oral lesions, however, attention to oral health care has been lacking, especially in the developing countries with higher burden of renal diseases. METHODS: One hundred and eighty patients, 90 cases and 90 controls were recruited, interviewed and examined. Oral mucosa assessment was based on the WHO Guide to Epidemiology and Diagnosis of Oral Mucosal Diseases. Urinalysis and blood creatinine levels were determined. Glomerular filtration rate (GFR) of each patient was calculated from the blood creatinine using Cockcroft and Gault formula. RESULTS: Oral lesions were present in 86 out of 90 (96.5%) CKD patients compared with 15 out of 90 (16.7%) controls (p < 0.001). Abnormal lip hyperpigmentation was the most frequently seen lesion in 81 out of 90 (90%) CKD patients. Other significant findings were gum bleeding, xerostomia, candidiasis, burning mouth and abnormal taste. In the controls (without CKD), the mean GFR was lower in subjects with oral lesions compared with those without oral lesions p < 0.001. CONCLUSIONS: CKD and reduced GFR in subjects without CKD are risk factors for oral lesions. The higher prevalence of oral lesions in CKD patients necessitates mandatory oral screening to identify patients with deteriorating renal function. The management of such lesions will enhance the overall well-being of CKD patients in developing countries.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150420
[Lr] Last revision date:150420
[Js] Journal subset:D; IM
[St] Status:In-Process
[do] DOI:10.1186/s12903-015-0004-z

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[PMID]: 25518280
[Au] Autor:Vidovic V; Nikolic I; Vukojevic J; Samardzija G; Kukic B; Bogdanovic B; Petrovic N
[Ti] Title:Unusual metastasis of esophageal cancer.
[So] Source:Vojnosanit Pregl;71(10):975-7, 2014 Oct.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin and lips. CASE REPORT: We presented a 56- year-old man who reported to his physician because of upper lip swelling. A physical checkup of the patients also showed a lesion on the skin of the left temporal region and both lesions were biopsied. Based on the results of histopathological and immunohistochemical analyses of the samples a diagnosis of metastatic adenocarcinoma to the skin was established. Additional diagnostic procedures, including esophagogastroduodenoscopy, detected the infiltration into the distal part of esophagus, which was histopathologically confirmed as adenocarcinoma of esophagus. The results of positron emission tomography/computed tomography (PET/CT) examination showed the invasion of the disease. Because of the disease expansion, a multidisciplinary oncology team suggested chemo- and radiotherapy treatment. The patient has received 4 cycles of platinum-based chemotherapy so far. CONCLUSION: The physicians should always consider unusual skin lesions as the first sign of cancer spreading.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

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[PMID]: 25209227
[Au] Autor:Farronato G; Kairyte L; Giannini L; Galbiati G; Maspero C
[Ad] Address:Via Commenda 10, 20122 Milan Italy. giampietro.farronato@unimi.it.
[Ti] Title:How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? literature review.
[So] Source:Stomatologija;16(2):53-60, 2014.
[Is] ISSN:1822-301X
[Cp] Country of publication:Lithuania
[La] Language:eng
[Ab] Abstract:OBJECTIVES. Cleft lip palate is congenital growth disease with unknown etiology, probably linked to both genetically and external causes. The aim of this work consists in presenting the effects of these diseases on cranio facial growth and the surgical protocols described in literature. MATERIALS AND METHODS. The literature review articles conducted by Medline ranged from 1998 to 2011 have been selected. The key words of the research were "cleft lip palate", "cleft lip palate facial growth", "cleft lip palate surgery". The inclusion criteria were articles that analyzed surgical protocols and the growth of unilateral lip and palate clefts, the timing repair of lip, palate and alveolus. We excluded case reports, studies without control group in the sample and the other types of publication as thesis or conference presentation. 60 articles had the selection criteria of the research. RESULTS. The cleft lip and palate is one of the most common birth defects that needs long rehabilitation between birth and adulthood. Several authors have presented surgical protocols and timing. The effects of these diseases on cranio facial growth and the importance of the early intervention have been described. CONCLUSIONS. The review describes the main surgical protocols and treatment strategies of the unilateral lip and palate clefts. The review discusses how surgery effects the midfacial skeletal growth. Studies agree that the palate repair is the main cause of the maxilla growth disturbances. About the timing of palate repair in the unilateral clefts it can be concluded that most studies found no difference between one or two stages palate repair techniques for the midfacial growth. Also from the research, studies agree that delayed hard palate repair has more positive effects on maxillary growth than that of early hard palate repair. Nevertheless good results, delayed hard palate repair technique is abandoned by many hospital centres because of worse speech outcome. The best technique of palate repair is difficult to conclude, because the research results are part of a big controversy between the centers. From the studies about the alveolar repair it can be concluded that the primary bone grafting had more negative results on the skeletal growth. Gingivoperiosteoplasty and the secondary bone grafting had more positive results for intracranial relationship. The studies agree that the best timing of lip repair is during third-sixth month of life and that lip repair could have negative influence on the maxillary growth.
[Mh] MeSH terms primary: Cleft Lip/surgery
Cleft Palate/surgery
Malocclusion/etiology
Maxillofacial Development/physiology
[Mh] MeSH terms secundary: Age Factors
Alveolar Bone Grafting
Humans
Maxilla/growth & development
Reconstructive Surgical Procedures/methods
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1506
[Js] Journal subset:D; IM
[Da] Date of entry for processing:140911
[St] Status:MEDLINE

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[PMID]: 25187268
[Au] Autor:da Silva Rath IB; Beltrame AP; Carvalho AP; Schaeffer MB; Almeida IC
[Ad] Address:Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil....
[Ti] Title:HIV-associated salivary gland disease - clinical or imaging diagnosis?
[So] Source:Int J Paediatr Dent;25(4):233-8, 2015 Jul.
[Is] ISSN:1365-263X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This work aimed at studying the salivary gland disease (SGD) as it relates to associated factors, such as persistent generalised lymphadenopathy (PGL), lymphocytic interstitial pneumonia (LIP), clinical and immunological features of AIDS, and salivary flow rate and pH, as well as at exploring the relationship between the clinical diagnosis and the imaging diagnosis by ultrasound (US) examination of the parotid glands. METHODS: Information regarding the observation of parotid gland enlargement, PGL, LIP, and clinical and immunological features of AIDS was gathered from medical records, and a saliva sample for unstimulated salivary flow rate and pH measurement was collected from 142 children aged 3 through 10 years treated at the Department of Infectious Diseases of Joana de Gusmão Children's Hospital, Florianópolis, SC, Brazil. High-resolution ultrasonography was performed in 58 children. Pearson's chi-square test and t-test were used to evaluate the association between the variables. RESULTS: A significant association was found between SGD and LIP. Ultrasound revealed a 50% higher incidence of SGD that was not reported in the patients' records. CONCLUSION: US examination proved to be essential for the correct diagnosis and monitoring of the progression of HIV/SGD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:D
[St] Status:In-Data-Review
[do] DOI:10.1111/ipd.12133

  10 / 5670 MEDLINE  
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[PMID]: 25422454
[Au] Autor:Graf AB; Andersen RA
[Ad] Address:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 graf@vis.caltech.edu andersen@vis.caltech.edu.
[Ti] Title:Brain-machine interface for eye movements.
[So] Source:Proc Natl Acad Sci U S A;111(49):17630-5, 2014 Dec 9.
[Is] ISSN:1091-6490
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A number of studies in tetraplegic humans and healthy nonhuman primates (NHPs) have shown that neuronal activity from reach-related cortical areas can be used to predict reach intentions using brain-machine interfaces (BMIs) and therefore assist tetraplegic patients by controlling external devices (e.g., robotic limbs and computer cursors). However, to our knowledge, there have been no studies that have applied BMIs to eye movement areas to decode intended eye movements. In this study, we recorded the activity from populations of neurons from the lateral intraparietal area (LIP), a cortical node in the NHP saccade system. Eye movement plans were predicted in real time using Bayesian inference from small ensembles of LIP neurons without the animal making an eye movement. Learning, defined as an increase in the prediction accuracy, occurred at the level of neuronal ensembles, particularly for difficult predictions. Population learning had two components: an update of the parameters of the BMI based on its history and a change in the responses of individual neurons. These results provide strong evidence that the responses of neuronal ensembles can be shaped with respect to a cost function, here the prediction accuracy of the BMI. Furthermore, eye movement plans could be decoded without the animals emitting any actual eye movements and could be used to control the position of a cursor on a computer screen. These findings show that BMIs for eye movements are promising aids for assisting paralyzed patients.
[Mh] MeSH terms primary: Brain-Computer Interfaces
Eye Movements/physiology
Saccades/physiology
[Mh] MeSH terms secundary: Animals
Bayes Theorem
Behavior
Brain/physiology
Electrodes
Haplorhini
Humans
Learning
Male
Neurodegenerative Diseases/immunology
Neurons/physiology
Paralysis/rehabilitation
Parietal Lobe/physiology
Reproducibility of Results
Time Factors
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Cu] Class update date: 150609
[Lr] Last revision date:150609
[Js] Journal subset:IM
[Da] Date of entry for processing:141210
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1419977111


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