Database : MEDLINE
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[PMID]: 26002622
[Au] Autor:Hetterich H; Willner M; Habbel C; Herzen J; Hoffmann VS; Fill S; Hipp A; Marschner M; Schüller U; Auweter S; Massberg S; Reiser MF; Pfeiffer F; Saam T; Bamberg F
[Ad] Address:From the *Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich; †Physics Department & Institute for Medical Engineering, Technical University Munich, Garching; ‡Institute for Medical Information Sciences, Biometry and Epidemiology, §Center for Neuropathology, Ludwig-Maximilians-University; and ∥Division of Cardiology, Ludwig-Maximilians-University Hospital, Munich, Germany.
[Ti] Title:X-ray phase-contrast computed tomography of human coronary arteries.
[So] Source:Invest Radiol;50(10):686-94, 2015 Oct.
[Is] ISSN:1536-0210
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The objective of this study was to assess the potential of grating-based phase-contrast computed tomography (gb-PCCT) for the detection and characterization of human coronary artery disease in an experimental ex vivo validation study. MATERIALS AND METHODS: The study was approved by the institutional review board, and informed consent was obtained from all patients. Specimens were examined using a conventional low-coherence x-ray tube (40 kV) and a Talbot-Lau grating interferometer. Histopathologic assessment was used as the standard of reference. Signal characteristics of calcified, fibrous (FIB), and lipid-rich (LIP) tissue were visually and quantitatively assessed by phase-contrast Hounsfield units (HU). Conventional absorption-based HU values were also measured. Conservative measurements of diagnostic accuracy for the detection and differentiation of plaque components as well as quantitative measurements of vessel dimensions were obtained, and receiver operating characteristic curve analysis for plaque differentiation was performed. RESULTS: A total of 15 coronary arteries from 5 subjects were available for analysis (386 sections). Calcified, FIB, and LIP displayed distinct gb-PCCT signal criteria. The diagnostic accuracy of gb-PCCT was high with sensitivity, specificity, and negative and positive predictive values of 0.89 or greater for all plaque components with good interrater agreement (к ≥ 0.88). In addition, quantitative measurements of vessel dimensions in gb-PCCT were strongly correlated with measurements obtained from histopathology (Pearson R ≥ 0.86). Finally, phase-contrast Hounsfield units were superior to conventional HU in differentiating FIB and LIP (receiver operating characteristic analysis, 0.86 vs. 0.77, respectively; P < 0.05). CONCLUSIONS: In an ex vivo setting, gb-PCCT provides improved differentiation and quantification of coronary atherosclerotic plaque and may thus serve as a tool for nondestructive histopathology.
[Mh] MeSH terms primary: Coronary Angiography/methods
Coronary Artery Disease/radiography
Coronary Vessels/radiography
Tomography, X-Ray Computed/methods
[Mh] MeSH terms secundary: Dissection
Humans
Plaque, Atherosclerotic/radiography
ROC Curve
Reproducibility of Results
Sensitivity and Specificity
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Entry month:1606
[Js] Journal subset:IM
[Da] Date of entry for processing:150904
[St] Status:MEDLINE
[do] DOI:10.1097/RLI.0000000000000169

  2 / 5379 MEDLINE  
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[PMID]: 26468799
[Au] Autor:Nadon F; Chaput B; Périssé J; de Bérail A; Lauwers F; Lopez R
[Ad] Address:*Maxillofacial and Facial Plastic Unit, University Toulouse Purpan †Plastic and Reconstructive Surgery Unit, Faculty of Medicine, University Toulouse Rangueil, Toulouse, France.
[Ti] Title:Interest of Mineralized Plasmatic Matrix in Secondary Autogenous Bone Graft for the Treatment of Alveolar Clefts.
[So] Source:J Craniofac Surg;26(7):2148-51, 2015 Oct.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, autologous blood products high in platelet concentrations have recently been developed. On the basis of our experience with PRP (platelet-rich plasma) and PRF (platelet-rich fibrin), we developed MPM, which contains platelets and fibrin concentrate in a liquid state; these materials can become bound to bone particles. The filling material is easy to shape and a PRF-type membrane is also generated. Ten patients with cleft lips and alveoli, with or without cleft palates (median, or uni- or bilateral) benefited from secondary bone grafts placed using our new material. We transferred autogenous bone from the iliac crest, an abundant source of cancellous bone associated with a high success rate. The 6-month outcomes of all patients were excellent in terms of both bone graft stability and closure of the oronasal fistulae. The preparation procedure is simple and the technical requirements minimal. Upon further optimization, MPM may serve as a third-generation platelet concentrate with potential applications in various fields.
[Mh] MeSH terms primary: Alveolar Bone Grafting/methods
Autografts/transplantation
Blood Platelets/physiology
Bone Transplantation/methods
Fibrin/therapeutic use
[Mh] MeSH terms secundary: Adolescent
Bone Regeneration/physiology
Child
Cleft Lip/surgery
Cleft Palate/surgery
Female
Follow-Up Studies
Humans
Ilium/transplantation
Male
Nose Diseases/surgery
Oral Fistula/surgery
Osteogenesis/physiology
Respiratory Tract Fistula/surgery
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:9001-31-4 (Fibrin)
[Em] Entry month:1606
[Js] Journal subset:D
[Da] Date of entry for processing:151016
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000001951

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[PMID]: 26174874
[Au] Autor:Ramírez GA; Rodríguez F; Herráez P; Castro-Alonso A; Andrada M; Espinosa-de-los-Monteros A
[Ad] Address:Unit of Histology and Veterinary Pathology, Institute for Animal Health, Veterinary College, University of Las Palmas de Gran Canaria, Campus Universitario Cardones, Arucas, Las Palmas, 45413, Spain....
[Ti] Title:Ultrastructural characterization of normal Merkel cells in the dog.
[So] Source:Vet Dermatol;26(5):328-33, e68-9, 2015 Oct.
[Is] ISSN:1365-3164
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Involvement of Merkel cells (MKs) in different cutaneous diseases as well as in the growth, differentiation and homeostasis of the skin has been previously documented. HYPOTHESIS/OBJECTIVES: The aim was to assess the ultrastructural features of MKs in canine skin, including morphometrics, highlighting their similarities with and differences from those described for other mammals. ANIMALS: Hard palate, nasal planum, lower lip and whisker pad samples were taken from two healthy young dogs destined for academic purposes. METHODS: Ultrathin sections of samples fixed in osmium tetroxide and embedded in Epon 812 resin were stained with uranyl acetate and lead citrate and examined using a JEOL JEM 2010 transmission electron microscope. RESULTS: Ultrastructural characteristics included the following: (i) arrangement in clusters in the basal layer of the epidermis, oral mucosa and external follicular root sheath; (ii) inconstant link with nerve terminal; (iii) oval (10.27 ± 1.64 µm major axis) cell shape with large lobulated nuclei (5.98 ± 1.16 µm major axis); (iv) spine-like and thick cytoplasmic processes interdigitating with surrounding keratinocytes; (v) presence of desmosomes in the cell body or at the base of spine-like processes attaching to neighbouring keratinocytes; and (vi) cytoplasm containing loosely arranged intermediate filaments (10.04 ± 1.17 nm) and numerous dense-core granules (100.1 ± 17.12 nm) arranged in the basal portion of the cytoplasm. CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides the first complete description of the ultrastructural characteristics of MKs in the dog, enhancing our knowledge of the skin structure in this species and providing a basis for future physiological and pathological studies of the role of these cells in normal and damaged canine tissues.
[Mh] MeSH terms primary: Dogs/anatomy & histology
Merkel Cells/ultrastructure
[Mh] MeSH terms secundary: Animals
Lip/cytology
Lip/ultrastructure
Microscopy, Electron, Transmission/veterinary
Nose/cytology
Nose/ultrastructure
Palate, Hard/cytology
Palate, Hard/ultrastructure
Skin/cytology
Skin/ultrastructure
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1606
[Js] Journal subset:IM
[Da] Date of entry for processing:150903
[St] Status:MEDLINE
[do] DOI:10.1111/vde.12230

  4 / 5379 MEDLINE  
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[PMID]: 27192890
[Au] Autor:Puvabanditsin S; Herrera-Garcia G; Gengel N; Hussein K; February M; Mayne J; Mehta R
[Ti] Title:PARTIAL TRISOMY 4p AND PARTIAL MONOSOMY 13q: CASE REPORT AND A LITERATURE REVIEW.
[So] Source:Genet Couns;27(1):35-41, 2016.
[Is] ISSN:1015-8146
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:We report on a term first born dichorionic-diamniotic twin with deletion of the distal long arm of chromosome 13, partial trisomy of the short arm of chromosome 4, intrauterine growth retardation, and multiple anomalies including microcephaly, colpocephaly, absent corpus callosum, bulbous tip of the nose, large and low set ears, macroglossia, thin upper lip, double outlet right ventricle, atria/ventricular septal defect, cleft mitral valve, pulmonary stenosis, single umbilical artery, multicystic dysplastic left kidney, sacral dimple, anterior displacement of anus, simian creases, abnormal thumb (congenital clasped thumb), overlapping toes, and congenital hypothyroidism. This is the first report of a patient with partial trisomy 4p and partial monosomy 13q.
[Mh] MeSH terms primary: Abnormalities, Multiple/genetics
Chromosome Disorders/genetics
Diseases in Twins/genetics
Fetal Growth Retardation
Pregnancy Complications, Neoplastic/surgery
Trisomy/genetics
[Mh] MeSH terms secundary: Chromosome Deletion
Chromosomes, Human, Pair 13/genetics
Chromosomes, Human, Pair 4/genetics
Female
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Neoplastic/drug therapy
Prenatal Diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1606
[Js] Journal subset:IM
[Da] Date of entry for processing:160519
[St] Status:MEDLINE

  5 / 5379 MEDLINE  
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[PMID]: 26456150
[Au] Autor:Awoyale T; Onajole AT; Ogunnowo BE; Adeyemo WL; Wanyonyi KL; Butali A
[Ad] Address:Lagos University Teaching Hospital, Lagos, Nigeria....
[Ti] Title:Quality of life of family caregivers of children with orofacial clefts in Nigeria: a mixed-method study.
[So] Source:Oral Dis;22(2):116-22, 2016 Mar.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:BACKGROUND: Orofacial clefts (OFCs) are common birth defects that may impose a large burden on the health and psychosocioeconomic well-being of affected individuals and families. This study aims to identify qualitative factors that affect the quality of life (QOL) of family caregivers of children with OFCs. METHODS: A mixed-method study in which family caregivers of OFCs children were consecutively recruited from cleft clinics over a 3-month period. Quantitative data were analyzed using SPSS version 17 and focus group discussion by framework analysis. RESULTS: A total of 107 caregivers participated in the entire study, and 24 caregivers participated in the focus group discussions. About 50% of the children had cleft lip and palate (CLP), 28% with cleft lips only (CL) and 23.4% with cleft palate only (CP). Poor access to specific information and lack of empathy of professionals affected the quality of life and delivery of family-centered care. CONCLUSIONS: To improve the quality of life of family caregivers, individual-focused counseling sessions should be organized for caregivers soon after birth. This will provide an opportunity to discuss the laid out plans for supportive care. It will also be as an avenue to address the arising social issues by health professionals and counselors.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Cu] Class update date: 160206
[Lr] Last revision date:160206
[Js] Journal subset:D
[St] Status:In-Process
[do] DOI:10.1111/odi.12379

  6 / 5379 MEDLINE  
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[PMID]: 26848196
[Au] Autor:Arias Urueña L; Briceño Balcazar I; Martinez Lozano J; Collins A; Uricoechea Patiño DA
[Ad] Address:Medical School. Universidad de La Sabana, Bogota, Colombia....
[Ti] Title:Clinical Aspects associated with Syndromic forms of Orofacial Clefts in a Colombian population.
[So] Source:Colomb Med (Cali);46(4):162-7, 2015 Oct-Dec.
[Is] ISSN:1657-9534
[Cp] Country of publication:Colombia
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nested-series of cases. METHODS: A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, and distribution of Orofacial Clefts according to sex and affected-side were determined. Odds ratios were calculated as measures of association between syndromic forms and antenatal high-risk conditions, preterm birth and comorbidities. A total of three hundred and eleven patients with Orofacial Clefts were assessed in a 12-month period. RESULTS: The most frequent type of Orofacial Clefts was cleft lip and palate, this type of cleft was more frequent in males, whereas cleft palate occurred more often in females. The most common cases occurred as non-syndromic forms. Aarskog-Scott syndrome showed the highest frequency amongst syndromic forms. Hypertensive disorders in pregnancy, developmental dysplasia of the hip, central nervous diseases and respiratory failure showed significant statistical associations (p <0.05) with syndromic forms. CONCLUSIONS: These data provide an epidemiological reference of Orofacial Clefts in Colombia. Novel associations between syndromic forms and clinical variables are determined. In order to investigate causality relationships between these variables further studies must be carried out.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Cu] Class update date: 160207
[Lr] Last revision date:160207
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 5379 MEDLINE  
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[PMID]: 26006106
[Au] Autor:Dev S; Kumari S; Singh N; Kumar Bal S; Seth P; Mukhopadhyay CK
[Ad] Address:Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, India....
[Ti] Title:Role of extracellular Hydrogen peroxide in regulation of iron homeostasis genes in neuronal cells: Implication in iron accumulation.
[So] Source:Free Radic Biol Med;86:78-89, 2015 Sep.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Iron accumulation and oxidative stress are associated with neurodegenerative disease. Labile iron is known to catalyze free radical generation and subsequent neuronal damage, whereas the role of oxidative stress in neuronal iron accumulation is less well understood. Here, we examined the effect of hydrogen peroxide (H2O2) treatment on cellular iron-uptake, -storage, and -release proteins in the neuroblastoma cell line SH-SY5Y. We found no detectable change in the iron-uptake proteins transferrin receptor-1 and divalent metal ion transporter. In contrast, H2O2 treatment resulted in significant degradation of the iron-exporter ferroportin (Fpn). A decrease in Fpn is expected to increase the labile iron pool (LIP), reducing the iron-regulatory protein (IRP)-iron-responsive element interaction and increasing the expression of ferritin-H (Ft-H) for iron storage. Instead, we detected IRP1 activation, presumably due to oxidative stress, and a decrease in Ft-H translation. A reduction in Ft-H mRNA was also observed, probably dependent on an antioxidant-response element present in the Ft-H enhancer. The decrease in Fpn and Ft-H upon H2O2 treatment led to a time-dependent increase in the cellular LIP. Our study reveals a complex regulation of neuronal iron-release and iron-storage components in response to H2O2 that may explain iron accumulation detected in neurodegenerative diseases associated with oxidative stress.
[Mh] MeSH terms primary: Gene Expression Regulation
Homeostasis
Hydrogen Peroxide/metabolism
Iron/metabolism
Neurons/metabolism
[Mh] MeSH terms secundary: Antioxidant Response Elements
Apoferritins/genetics
Apoferritins/metabolism
Cation Transport Proteins/metabolism
Cell Line, Tumor
Down-Regulation
Enhancer Elements, Genetic
Humans
Hydrogen Peroxide/pharmacology
Oxidative Stress
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Cation Transport Proteins); 0 (FTL protein, human); 0 (metal transporting protein 1); 9013-31-4 (Apoferritins); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Entry month:1606
[Cu] Class update date: 160315
[Lr] Last revision date:160315
[Js] Journal subset:IM
[Da] Date of entry for processing:150831
[St] Status:MEDLINE

  8 / 5379 MEDLINE  
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[PMID]: 26372225
[Au] Autor:Cameron TL; Bell KM; Gresshoff IL; Sampurno L; Mullan L; Ermann J; Glimcher LH; Boot-Handford RP; Bateman JF
[Ad] Address:Murdoch Childrens Research Institute, Parkville, Victoria, Australia....
[Ti] Title:XBP1-Independent UPR Pathways Suppress C/EBP-ß Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease.
[So] Source:PLoS Genet;11(9):e1005505, 2015 Sep.
[Is] ISSN:1553-7404
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying MCDS through the expression of an exogenous misfolding protein in the endoplasmic reticulum (ER) in hypertrophic chondrocytes have demonstrated the central importance of ER stress in the pathology of MCDS. The resultant unfolded protein response (UPR) in affected chondrocytes involved activation of canonical ER stress sensors, IRE1, ATF6, and PERK with the downstream effect of disrupted chondrocyte differentiation. Here, we investigated the role of the highly conserved IRE1/XBP1 pathway in the pathology of MCDS. Mice with a MCDS collagen X p.N617K knock-in mutation (ColXN617K) were crossed with mice in which Xbp1 was inactivated specifically in cartilage (Xbp1CartΔEx2), generating the compound mutant, C/X. The severity of dwarfism and hypertrophic zone expansion in C/X did not differ significantly from ColXN617K, revealing surprising redundancy for the IRE1/XBP1 UPR pathway in the pathology of MCDS. Transcriptomic analyses of hypertrophic zone cartilage identified differentially expressed gene cohorts in MCDS that are pathologically relevant (XBP1-independent) or pathologically redundant (XBP1-dependent). XBP1-independent gene expression changes included large-scale transcriptional attenuation of genes encoding secreted proteins and disrupted differentiation from proliferative to hypertrophic chondrocytes. Moreover, these changes were consistent with disruption of C/EBP-ß, a master regulator of chondrocyte differentiation, by CHOP, a transcription factor downstream of PERK that inhibits C/EBP proteins, and down-regulation of C/EBP-ß transcriptional co-factors, GADD45-ß and RUNX2. Thus we propose that the pathology of MCDS is underpinned by XBP1 independent UPR-induced dysregulation of C/EBP-ß-mediated chondrocyte differentiation. Our data suggest that modulation of C/EBP-ß activity in MCDS chondrocytes may offer therapeutic opportunities.
[Mh] MeSH terms primary: Bone Diseases/pathology
CCAAT-Enhancer-Binding Protein-beta/antagonists & inhibitors
Cell Differentiation/physiology
Chondrocytes/pathology
DNA-Binding Proteins/physiology
Endoplasmic Reticulum Stress/physiology
Transcription Factors/physiology
Unfolded Protein Response/physiology
[Mh] MeSH terms secundary: Animals
CCAAT-Enhancer-Binding Protein-beta/physiology
DNA-Binding Proteins/genetics
Gene Expression Profiling
Mice
Mice, Transgenic
Transcription Factors/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (CCAAT-Enhancer-Binding Protein-beta); 0 (DNA-Binding Proteins); 0 (Transcription Factors); 0 (regulatory factor X transcription factors)
[Em] Entry month:1605
[Cu] Class update date: 151215
[Lr] Last revision date:151215
[Js] Journal subset:IM
[Da] Date of entry for processing:150916
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1005505

  9 / 5379 MEDLINE  
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[PMID]: 26291419
[Au] Autor:Fantus SA; Zech LA; Hensley J; Norton SA; Dugan EM
[Ad] Address:*Georgetown University School of Medicine, Washington, DC; and †Department of Dermatology, Washington Hospital Center, Georgetown University, Washington, DC.
[Ti] Title:Vegetating Plaques on the Lips. Pyostomatitis vegetans.
[So] Source:Am J Dermatopathol;37(9):699-700, 730-2, 2015 Sep.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Lip Diseases/pathology
Pyoderma/pathology
Stomatitis/pathology
[Mh] MeSH terms secundary: Anti-Inflammatory Agents/therapeutic use
Female
Fluocinonide/therapeutic use
Humans
Lip Diseases/drug therapy
Middle Aged
Prednisone/therapeutic use
Pyoderma/drug therapy
Stomatitis/drug therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents); 2W4A77YPAN (Fluocinonide); VB0R961HZT (Prednisone)
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:150821
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000217

  10 / 5379 MEDLINE  
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[PMID]: 24102903
[Au] Autor:Marquezin MC; Gavião MB; Alonso MB; Ramirez-Sotelo LR; Haiter-Neto F; Castelo PM
[Ad] Address:Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
[Ti] Title:Relationship between orofacial function, dentofacial morphology, and bite force in young subjects.
[So] Source:Oral Dis;20(6):567-73, 2014 Sep.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim was to evaluate the relationship between orofacial function, dentofacial morphology, and bite force in young subjects. SUBJECTS AND METHODS: Three hundred and sixteen subjects were divided according to dentition stage (early, intermediate, and late mixed and permanent dentition). Orofacial function was screened using the Nordic Orofacial Test-Screening (NOT-S). Orthodontic treatment need, bite force, lateral and frontal craniofacial dimensions and presence of sleep bruxism were also assessed. The results were submitted to descriptive statistics, normality and correlation tests, analysis of variance, and multiple linear regression to test the relationship between NOT-S scores and the studied independent variables. RESULTS: The variance of NOT-S scores between groups was not significant. The evaluation of the variables that significantly contributed to NOT-S scores variation showed that age and presence of bruxism related to higher NOT-S total scores, while the increase in overbite measurement and presence of closed lip posture related to lower scores. Bite force did not show a significant relationship with scores of orofacial dysfunction. No significant correlations between craniofacial dimensions and NOT-S scores were observed. CONCLUSION: Age and sleep bruxism were related to higher NOT-S scores, while the increase in overbite measurement and closed lip posture contributed to lower scores of orofacial dysfunction.
[Mh] MeSH terms primary: Bite Force
Dentition
Overbite/physiopathology
Sleep Bruxism/physiopathology
[Mh] MeSH terms secundary: Adolescent
Age Factors
Cephalometry
Child
Deglutition
Female
Humans
Lip/physiopathology
Male
Mastication
Posture
Speech
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1605
[Js] Journal subset:D
[Da] Date of entry for processing:140826
[St] Status:MEDLINE
[do] DOI:10.1111/odi.12174


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