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[PMID]: 25356671
[Au] Autor:Pederson H; Okland T; Boyers LN; Karimkhani C; Rosenfeld RM; Nasser M; Yoong SL; Wolfenden L; Kyu HH; Serina PT; Coggeshall M; Dellavalle RP
[Ad] Address:University of Colorado School of Medicine, Aurora....
[Ti] Title:Identifying otolaryngology systematic review research gaps: comparing global burden of disease 2010 results with cochrane database of systematic review content.
[So] Source:JAMA Otolaryngol Head Neck Surg;141(1):67-72, 2015 Jan 1.
[Is] ISSN:2168-619X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:IMPORTANCE: Burden of disease should inform research prioritization. OBJECTIVE: To determine whether systematic reviews and protocols published in the Cochrane Database of Systematic Reviews (CDSR) appropriately reflect disease burden for otolaryngologic conditions as measured by the Global Burden of Disease (GBD) 2010 project. DESIGN: Two investigators independently assessed 10 otolaryngologic conditions in CDSR for systematic review and protocol representation from March to June 2014. The otolaryngologic diseases were matched to their respective GBD 2010 disability-adjusted life-years (DALYs) to assess their correlation. MAIN OUTCOMES AND MEASURES: Relationship of CDSR representation (based on systematic reviews and protocols) with percentage of total 2010 DALYs, 2010 DALY rank, and DALY percentage change from 1990 to 2010 for 10 otolaryngologic conditions. RESULTS: All 10 otolaryngologic conditions were represented by at least 1 systematic review in CDSR. The number of reviews and protocols in CDSR was well matched with GBD 2010 disability metrics for only 1 disease, mouth cancer. Upper respiratory infections, otitis media, thyroid cancer, and cleft lip and cleft palate were overrepresented in CDSR, and esophageal cancer, "other hearing loss," nasopharynx cancer, larynx cancer, and "cancer of other part of pharynx and oropharynx" were underrepresented. CONCLUSIONS AND RELEVANCE: The representation of otolaryngologic conditions in CDSR correlates poorly with DALY metrics. The results of this study may guide future research prioritization and allocation of funds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1001/jamaoto.2014.2700

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[PMID]: 25263567
[Au] Autor:Ourique AF; Chaves Pdos S; Souto GD; Pohlmann AR; Guterres SS; Beck RC
[Ad] Address:Programa de Pós-Graduação em Nanotecnologia Farmacêutica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil....
[Ti] Title:Redispersible liposomal-N-acetylcysteine powder for pulmonary administration: development, in vitro characterization and antioxidant activity.
[So] Source:Eur J Pharm Sci;65:174-82, 2014 Dec 18.
[Is] ISSN:1879-0720
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Liposomal dry powders of N-acetylcysteine (SD-NAC-Lip) were developed for pulmonary administration. Liposomes were prepared by reverse phase evaporation and spray dried using lactose (10%, w/w) as drying adjuvant. The powders were characterized according to process yield, drug content, residual water content, particle size distribution, morphology and redispersion behavior. In vitro aerosol performance was evaluated using an eight-stage Andersen Cascade Impactor. Moreover, in vitro antioxidant activity was determined by measuring thiobarbituric acid reactive species (TBARS) present in the lungs of healthy Wistar rats after induction of oxidation by iron/EDTA. The spray-drying process had a high yield (71%±2), drug content (mg/g) according to the expected value, moisture content below 9%, geometric mean diameter under 3µm with span value lower than 1. Spherical particles were observed by scanning electron microscopy. Liposomal dry-powders were able to recover the nanometric size of the original dispersion after their redispersion in aqueous medium, as shown by laser diffraction and transmission electron microscopy. Furthermore, the powders presented aerodynamic diameter of about 7µm and respirable fraction above 30%, indicating suitable properties for pulmonary use. The encapsulation of N-acetylcysteine in liposomes was essential to maintain its in vitro antioxidant activity after the drying process. In addition, the powder containing the encapsulated drug had better in vitro antioxidant activity than the liquid and solid formulations containing the non-encapsulated drug, which makes it a good candidate for the treatment of pulmonary diseases associated with oxidative stress.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Process

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[PMID]: 25365223
[Au] Autor:Perino A; Pols TW; Nomura M; Stein S; Pellicciari R; Schoonjans K
[Ti] Title:TGR5 reduces macrophage migration through mTOR-induced C/EBPß differential translation.
[So] Source:J Clin Invest;124(12):5424-36, 2014 Dec 1.
[Is] ISSN:1558-8238
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of macrophage-specific TGR5 signaling in protecting adipose tissue from inflammation and associated insulin resistance. Examination of adipose tissue from obese mice lacking macrophage Tgr5 revealed enhanced inflammation, increased chemokine expression, and higher macrophage numbers compared with control obese animals. Moreover, macrophage-specific deletion of Tgr5 exacerbated insulin resistance in obese animals. Conversely, pharmacological activation of TGR5 markedly decreased LPS-induced chemokine expression in primary macrophages. This reduction was mediated by AKT-dependent activation of mTOR complex 1, which in turn induced the differential translation of the dominant-negative C/EBPß isoform, liver inhibitory protein (LIP). Overall, these studies reveal a signaling pathway downstream of TGR5 that modulates chemokine expression in response to high-fat diet and suggest that targeting this pathway has the potential to be therapeutically exploited for prevention of chronic inflammatory diseases and type 2 diabetes mellitus.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Js] Journal subset:AIM; IM
[St] Status:In-Process

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[PMID]: 23868653
[Au] Autor:Amrhein P; Sittel C; Spaich C; Kohlhase J; Boppert R; Kohlhof P; Koitschev A
[Ad] Address:Klinik für Hals- Nasen- Ohrenkrankheiten, Plastische Operationen, Klinikum Stuttgart, Stuttgart, Deutschland.
[Ti] Title:Speicheldrüsenchoristom im Mittelohr bei mittels Array-CGH diagnostiziertem branchiootorenalem Syndrom. [Middle ear salivary gland choristoma related to branchio-oto-renal syndrome diagnosed by array-CGH].
[So] Source:HNO;62(5):374-7, 2014 May.
[Is] ISSN:1433-0458
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Branchio-oto-renal (BOR) syndrome is characterized by ear malformations associated with sensorineural or mixed hearing loss. In addition, preauricular tags, preauricular pits, branchial cleft fistulas and cysts, as well as renal dysplasia are seen. A genetic mutation on chromosome 8, either autosomal dominantly inherited or occuring as a spontaneous mutation, is the cause in the majority of cases. Using array-based comparative genomic hybridization (CGH), it is possible to detect even the smallest genetic changes. Salivary gland choristoma in the middle ear is very rare. Surgical removal and histological clarification are required.
[Mh] MeSH terms primary: Branchio-Oto-Renal Syndrome/genetics
Choristoma/genetics
Comparative Genomic Hybridization/methods
Ear Diseases/genetics
Ear, Middle/surgery
Genetic Predisposition to Disease/genetics
Salivary Glands/surgery
[Mh] MeSH terms secundary: Branchio-Oto-Renal Syndrome/surgery
Choristoma/surgery
Ear Diseases/surgery
Humans
Infant
Male
Mutation/genetics
Oligonucleotide Array Sequence Analysis/methods
Treatment Outcome
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140508
[St] Status:MEDLINE
[do] DOI:10.1007/s00106-013-2728-x

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[PMID]: 24786163
[Au] Autor:Hay Kraus BL
[Ad] Address:Department of Clinical Sciences, Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
[Ti] Title:Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs.
[So] Source:J Am Vet Med Assoc;244(10):1164-9, 2014 May 15.
[Is] ISSN:1943-569X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the effectiveness of orally administered maropitant citrate in preventing vomiting after hydromorphone hydrochloride administration in dogs. DESIGN: Randomized, blinded, prospective clinical study. ANIMALS: 40 dogs with American Society of Anesthesiologists status of I or II, > 6 months of age, and weighing between 24 and 58.2 kg (52.8 and 128.04 lb). PROCEDURES: Dogs were randomly selected to receive maropitant (2.0 to 4.0 mg/kg [0.9 to 1.8 mg/lb]) or placebo (lactose monohydrate) orally 2 hours prior to receiving hydromorphone (0.1 mg/kg [0.045 mg/lb], IM). A blinded observer recorded the occurrence of vomiting or signs of nausea (eg, salivation or lip-licking) during a 30-minute period after hydromorphone administration. Two-tailed Fisher exact tests were used to compare the incidences of vomiting and signs of nausea with or without vomiting between treatment groups. Results-Of the 20 dogs receiving maropitant, none vomited but 12 (60%) developed signs of nausea. Of the 20 dogs receiving placebo, 5 (25%) vomited and 11 (55%) developed signs of nausea; overall, 16 of 20 (80%) dogs in the placebo treatment group vomited or developed signs of nausea. Compared with the effects of placebo, maropitant significantly decreased the incidence of vomiting but not signs of nausea in dogs administered hydromorphone. CONCLUSIONS AND CLINICAL RELEVANCE: Among the 40 study dogs, the incidence of vomiting associated with hydromorphone administration was 25%. Oral administration of maropitant prevented vomiting but not signs of nausea associated with hydromorphone administration in dogs.
[Mh] MeSH terms primary: Analgesics, Opioid/adverse effects
Antiemetics/therapeutic use
Dog Diseases/chemically induced
Hydromorphone/adverse effects
Quinuclidines/therapeutic use
Vomiting/veterinary
[Mh] MeSH terms secundary: Administration, Oral
Analgesics, Opioid/administration & dosage
Animals
Antiemetics/administration & dosage
Dog Diseases/prevention & control
Dogs
Female
Hydromorphone/administration & dosage
Male
Quinuclidines/administration & dosage
Vomiting/chemically induced
Vomiting/prevention & control
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Analgesics, Opioid); 0 (Antiemetics); 0 (Quinuclidines); 4XE2T9H4DH (maropitant); Q812464R06 (Hydromorphone)
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140505
[St] Status:MEDLINE
[do] DOI:10.2460/javma.244.10.1164

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[PMID]: 24719364
[Au] Autor:Ababneh FK; Al-Swaid A; Elhag A; Youssef T; Alsaif S
[Ad] Address:Division of Genetics, Department of Pediatrics, King Abdul Aziz Medical City for National Guard, Riyadh, Saudi Arabia.
[Ti] Title:Blepharo-cheilo-dontic (BCD) syndrome: expanding the phenotype, case report and review of literature.
[So] Source:Am J Med Genet A;164A(6):1525-9, 2014 Jun.
[Is] ISSN:1552-4833
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The combination of lagophthalmia, euryblepharon, ectropion of lower eyelids, distichiasis, bilateral cleft lip and palate, and oligodontia comprises the blepharo-cheilo-dontic (BCD) syndrome. This combination has been found sporadically or with positive family history and inherited as an autosomal dominant condition with variable expression. We described a Saudi boy with the cardinal signs consistent with the BCD syndrome. In addition to the common components of BCD syndrome that involve eyelids, lip, and teeth abnormalities, this patient is the third reported BCD case with imperforate anus, the second with thyroid agenesis, and the first with lumbosacral meningomyelocele.
[Mh] MeSH terms primary: Cleft Lip/genetics
Cleft Lip/pathology
Cleft Palate/genetics
Cleft Palate/pathology
Ectropion/genetics
Ectropion/pathology
Tooth Abnormalities/genetics
Tooth Abnormalities/pathology
[Mh] MeSH terms secundary: Anus, Imperforate
Eyelids/abnormalities
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases/genetics
Infant, Newborn, Diseases/pathology
Male
Saudi Arabia
Spinal Dysraphism
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140508
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.36465

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[PMID]: 24428492
[Au] Autor:Haga N; Nishie W; Hata H; Miyauchi T; Muramatsu K; Kitamura S; Osawa R; Shimizu H
[Ad] Address:Department of Dermatology, Hokkaido University Graduate School of Medicine, N15W7 Kita-ku, Sapporo, 060-8638, Japan.
[Ti] Title:Two cases of pseudolymphoma on the lips.
[So] Source:Br J Dermatol;170(5):1204-6, 2014 May.
[Is] ISSN:1365-2133
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Lip Diseases/pathology
Pseudolymphoma/pathology
[Mh] MeSH terms secundary: Adult
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; LETTER
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140520
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.12837

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[PMID]: 24586733
[Au] Autor:Sheu TT; Chiang BL; Yen JH; Lin WC
[Ad] Address:Department of Immunology, Tzu Chi University, Hualien, Taiwan, Republic of China ; Institute of Microbiology, Immunology and Biochemistry, Tzu Chi University, Hualien, Taiwan, Republic of China....
[Ti] Title:Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic mice.
[So] Source:PLoS One;9(2):e89379, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease. The incidence of most autoimmune diseases increases with age, and premature CD4(+) T cell aging has been reported in several autoimmune diseases. In this study, we tested the hypothesis that premature CD4(+) T cell aging can cause autoimmune disease by examining whether premature CD4(+) T cell aging exists and causes LIP in our mouse model. Non-obese diabetic (NOD) mice were used because, in addition to Treg defects, the LIP of T cells has been shown to plays a causative role in the development of insulin-dependent diabetes mellitus (IDDM) in these mice. We found that with advancing age, NOD mice exhibited an accelerated decrease in the number of CD4(+) T cells due to the loss of naïve cells. This was accompanied by an increase in the percentage of memory cells, leading to a reduced naïve/memory ratio. In addition, both the percentage of CD28(+) cells in CD4(+) T cells and IL-2 production decreased, while the percentage of FAS(+)CD44(+) increased, suggesting that NOD mice exhibit premature CD4(+) T cell aging. This process preferentially contributed to LIP of memory cells. Therefore, our results suggest that premature CD4(+) T cell aging underlies the development of IDDM in NOD mice. Given that CD28 and IL-2 play important roles in Treg function, the relationships between premature CD4(+) T cell aging and lymphopenia as well as Treg defects in autoimmune-prone NOD mice are proposed.
[Mh] MeSH terms primary: CD4-Positive T-Lymphocytes/immunology
Cell Aging
Cell Proliferation
Diabetes Mellitus, Experimental/immunology
Immunologic Memory
Lymphopenia/immunology
[Mh] MeSH terms secundary: Animals
Antigens, CD28/immunology
CD4-Positive T-Lymphocytes/cytology
Female
Interleukin-2/biosynthesis
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Obesity
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antigens, CD28); 0 (Interleukin-2)
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140303
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0089379

  9 / 5584 MEDLINE  
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[PMID]: 25219194
[Au] Autor:Yan B; Zhang Q; Cao L; Wei W
[Ti] Title:[Diagnosis and endoscopic therapy for lateral sphenoid sinus recess lesions].
[So] Source:Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;28(11):751-5, 2014 Jun.
[Is] ISSN:1001-1781
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To highlight concepts critical to achieving successful diagnosis and endoscopic therapy for lateral recess of the sphenoid sinus (LRSS) lesions, operative techniques, and avoiding complications in the treatment were discussed. METHOD: Pathology within a lateral recess of a widely pneumatized sphenoid sinus is difficult to access with the use of traditional open and current endoscopic surgical approaches. A new surgical procedure, the endoscopic tranapterygoid approach, directly accesses this region. A clinical experience over several years with this approach is reported as well as a refined and updated description of the technique. Twenty-six patients with LRSS lesions were retrospectively studied, from 2008 to 2013, 11 males and 15 females. Ages ranged from 21 to 68 years (mean 43 years). Radiological investigations consisted of computed tomography (CT) scan and magnetic resonance images (MRI) in all cases. An endoscopic tranapterygoid approach was performed in all patients under general aneasthesia, 4 to resect a middle fossa meningoencephalocele and repair the CSF leak and associated skull base defect. RESULT: All the operations were successful. Patients tolerated the approach well and no significant complications occurred. Post operative pathology made definite diagnosis. Meningoencephalocele 4 cases, sphenoid sinus cyst 10 cases (4 cases only were subtotal resected for it's tight adhesions with optic nerve or internal carotid artery) , fungal sinusitis 5 cases (non-invasive fungal sinusitis, pathogenic funga was aspergillus) chronic sphenoid sinusitis 5 cases. Nine patients had postoperative ipsilateral facial, upper lip and palatal hypesthesia, not given treatment, gradually relieved after 6 months. No recurrence was found during follow-up for 6 to 53 months (mean 23.8 months). CONCLUSION: It had very important implications for high resolution CT combined with MRI in diagnosis of LRSS lesions. In selected cases, the endoscopic tranapterygoid approach enables the otolaryngologist to meet modern demands to treat conditions in the lateral sphenoid using minimally invasive techniques that are well-tolerated by patients. The endoscopic transpterygoid approach is an excellent approach for dealing with LRSS lesions.
[Mh] MeSH terms primary: Paranasal Sinus Diseases/diagnosis
Paranasal Sinus Diseases/surgery
Sphenoid Sinus
[Mh] MeSH terms secundary: Adult
Aged
Endoscopy/methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retrospective Studies
Young Adult
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140915
[St] Status:MEDLINE

  10 / 5584 MEDLINE  
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[PMID]: 25404975
[Au] Autor:Tadesse L; Tafesse F; Hamamy H
[Ad] Address:Tehran University of Medical Sciences, Iran ; Freelancer, Addis Ababa, Ethiopia.
[Ti] Title:Communities and community genetics in Ethiopia.
[So] Source:Pan Afr Med J;18:115, 2014.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:eng
[Ab] Abstract:The rates of congenital and genetic disorders in low and middle income countries are similar or might be higher than in high income countries due to a multitude of risk factors and the dearth of community genetic services. To direct effective preventive, diagnostic and counseling services, collecting data on the incidence and prevalence of various congenital and genetic disorders and their risk factors is a pre-requisite for establishing genetic services at the community level and mainly at the primary health care setting. This brief review is meant to assess the available epidemiological data in Ethiopia pertaining to congenital and genetic disorders on which the future community genetic services could be built. Existing epidemiological data on congenital and genetic disorders in Ethiopia is limited, and the few studies conducted revealed that folate and iodine deficiencies are prevalent among women in the reproductive age. Pregnant women's infection with syphilis and rubella is prevailing. Based on available data, cleft lip and palate, congenital heart diseases, club-foot, and gastro-intestinal malformations are the most common birth defects in Ethiopia. Community based studies to accurately demonstrate the incidence and prevalence levels of these disorders are almost unavailable. To plan for organization and implementation of community genetic services at the primary health care level in Ethiopia, conducting standardized epidemiological studies is currently highly recommended.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Cu] Class update date: 150106
[Lr] Last revision date:150106
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.11604/pamj.2014.18.115.3172


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