Database : MEDLINE
Search on : Lip and Diseases [Words]
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[PMID]: 24983770
[Au] Autor:Fan Y; Zhang J; Cai L; Wang S; Liu C; Zhang Y; You L; Fu Y; Shi Z; Yin Z; Luo L; Chang Y; Duan X
[Ad] Address:Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050024, PR China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Science, Hebei Normal University, Shijiazhuang 050024, PR China; Key La...
[Ti] Title:The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages.
[So] Source:Biochim Biophys Acta;1843(11):2775-83, 2014 Nov.
[Is] ISSN:0006-3002
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH). Thus, FTL competes with the Fenton reaction by acting as an antioxidant. In the present study, we determined that FTL influences the lipopolysaccharide (LPS)-induced inflammatory response. FTL protein expression was regulated by LPS stimulation in RAW264.7 cells. To investigate the role of FTL in LPS-activated murine macrophages, we established stable FTL-expressing cells and used shRNA to silence FTL expression in RAW264.7 cells. Overexpression of FTL significantly decreased the LPS-induced production of tumor necrosis factor alpha (TNF-α), interleukin 1ß (IL-1ß), nitric oxide (NO) and prostaglandin E2 (PGE2). Additionally, overexpression of FTL decreased the LPS-induced increase of the intracellular labile iron pool (LIP) and reactive oxygen species (ROS). Moreover, FTL overexpression suppressed the LPS-induced activation of MAPKs and nuclear factor-κB (NF-κB). In contrast, knockdown of FTL by shRNA showed the reverse effects. Therefore, our results indicate that FTL plays an anti-inflammatory role in response to LPS in murine macrophages and may have therapeutic potential for treating inflammatory diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 5502 MEDLINE  
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[PMID]: 24296165
[Au] Autor:Bodner L; Manor E; Friger MD; van der Waal I
[Ad] Address:Department of Oral and Maxillofacial Surgery, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: lbodner@bgu.ac.il....
[Ti] Title:Oral squamous cell carcinoma in patients twenty years of age or younger--review and analysis of 186 reported cases.
[So] Source:Oral Oncol;50(2):84-9, 2014 Feb.
[Is] ISSN:1879-0593
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:To review the literature on reported cases of squamous cell carcinoma (SCC) of the oral cavity in patients twenty-years-of-age or younger. All well-documented cases of oral SCC in patients twenty-years-of-age or less, published between 1936 and 2012, were collected and the clinicopathologic features were evaluated. Primary cases of oral SCC were selected. Age, gender, intra-oral subsite were recorded. A total of 88 articles describing 186 cases were included. The group of otherwise healthy patients had a mean age of 14.08years (range newborn-20years), the m:f ratio was 1.36; the oral subsites were the tongue, gingiva, and lower lip. A second group of patients who have disorders that predispose to cancer development, such as xeroderma pigmentosum, Fanconi's anemia, and a history of bone marrow transplant, had a mean age of 13.17years (range 5-20years); the m:f ratio was 1.23; the oral subsite was mainly the tongue. There was a slight difference between otherwise healthy patients and patients with predisposing systemic factors, but this difference was not statistically significant. It contrast to adults, there is only a weak predilection for males (m:f ratio of 1.23-1.36). In the young population SCC occurs most frequently in the tongue, followed by gingiva and lips. Unlike in adults, SCC is very uncommon in the floor of mouth. Oral SCC may, indeed, occur in patients younger than 20years and clinicians should take cognizance of this. Periodical examination of the oral cavity of young patients is recommended in cases of systemic diseases that predispose to cancer development such as xeroderma pigmentosum, Fanconi's anemia, and a history of bone marrow transplant.
[Mh] MeSH terms primary: Carcinoma, Squamous Cell/epidemiology
Mouth Neoplasms/epidemiology
[Mh] MeSH terms secundary: Adolescent
Age Factors
Carcinoma, Squamous Cell/therapy
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Mouth Neoplasms/therapy
Prognosis
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140113
[St] Status:MEDLINE

  3 / 5502 MEDLINE  
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[PMID]: 25188152
[Au] Autor:Aubry MC
[Ad] Address:Mayo Clinic, Rochester, MN, USA.
[Ti] Title:Pulmonary Pathology: LC22-1 NON-NEOPLASTIC PULMONARY LYMPHOID PROLIFERATIONS.
[So] Source:Pathology;46 Suppl 2:S36-7, 2014 Oct.
[Is] ISSN:1465-3931
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Non-neoplastic pulmonary lymphoid proliferations encompass a spectrum of disease from small airway bronchiolar disease to diffuse interstitial disease. They include follicular bronchiolitis (FB), nodular lymphoid hyperplasia (NLH), and lymphocytic interstitial pneumonia (LIP). FB is characterized by the presence of hyperplastic lymphoid follicles with germinal centers, exquisitely bronchiolocentric. Patients with FB not uncommonly suffer from connective tissue disease such as rheumatoid arthritis or immunodeficiency. The differential diagnosis of FB includes other small airway diseases such as chronic bronchiolitis or constrictive bronchiolitis. In contrast, LIP is an interstitial lung disease with diffuse marked septal thickening by small lymphocytes, with admixed plasma cells and histiocytes. Patients with LIP often present with autoimmune disorders such as Sjögrens syndrome. Chronic hypersensitivity pneumonia and non-specific interstitial pneumonia enter the differential diagnosis of LIP. Patients with NLH are typically asymptomatic and present with solitary or multiple nodular infiltrates. The lung parenchyma is focally obliterated by a mass comprised of fibrosis admixed with a dense polymorphous lymphoid infiltrate, often with numerous germinal centers. By immunohistochemistry, the lymphoid infiltrate is predominantly CD3 + T-cells with CD20 + B-cells forming the germinal centers. The plasma cells and lymphocytes are polyclonal. NLH needs to be distinguished from low-grade lymphoma, mainly MALT lymphoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/01.PAT.0000454210.12598.39

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[PMID]: 24226379
[Au] Autor:De Caterina R; Husted S; Wallentin L; Andreotti F; Arnesen H; Bachmann F; Baigent C; Huber K; Jespersen J; Kristensen SD; Lip GY; Morais J; Rasmussen LH; Siegbahn A; Verheugt FW; Weitz JI
[Ad] Address:Raffaele De Caterina, MD, PhD, Institute of Cardiology, "G. d'Annunzio" University - Chieti, Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy, E-mail: rdecater@unich.it.
[Ti] Title:Vitamin K antagonists in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease.
[So] Source:Thromb Haemost;110(6):1087-107, 2013 Dec.
[Is] ISSN:0340-6245
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with the cyclic inter-conversion of vitamin K and its 2,3 epoxide, thus inhibiting γ-carboxylation of glutamate residues at the amino-termini of vitamin K-dependent proteins, including the coagulation factors (F) II (prothrombin), VII, IX and X, as well as of the anticoagulant proteins C, S and Z. The overall effect of such interference is a dose-dependent anticoagulant effect, which has been therapeutically exploited in heart disease since the early 1950s. In this position paper, we review the mechanisms of action, pharmacological properties and side effects of VKAs, which are used in the management of cardiovascular diseases, including coronary heart disease (where their use is limited), stroke prevention in atrial fibrillation, heart valves and/or chronic heart failure. Using an evidence-based approach, we describe the results of completed clinical trials, highlight areas of uncertainty, and recommend therapeutic options for specific disorders. Although VKAs are being increasingly replaced in most patients with non-valvular atrial fibrillation by the new oral anticoagulants, which target either thrombin or FXa, the VKAs remain the agents of choice for patients with atrial fibrillation in the setting of rheumatic valvular disease and for those with mechanical heart valves.
[Mh] MeSH terms primary: Anticoagulants/therapeutic use
Cardiology
Heart Diseases/drug therapy
Thrombosis/drug therapy
Vitamin K/antagonists & inhibitors
[Mh] MeSH terms secundary: Advisory Committees
Anticoagulants/pharmacology
Blood Coagulation/drug effects
Europe
Heart Diseases/blood
Humans
Societies, Medical
Thrombosis/blood
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anticoagulants); 12001-79-5 (Vitamin K)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:131127
[St] Status:MEDLINE
[do] DOI:10.1160/TH13-06-0443

  5 / 5502 MEDLINE  
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[PMID]: 25187723
[Au] Autor:Xu KF; Lo BH
[Ad] Address:Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China.
[Ti] Title:Lymphangioleiomyomatosis: differential diagnosis and optimal management.
[So] Source:Ther Clin Risk Manag;10:691-700, 2014.
[Is] ISSN:1176-6336
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:Lymphangioleiomyomatosis (LAM) is an uncommon disease presented as diffuse thin-walled cystic changes in the lung. The main differential diagnoses include pulmonary Langerhans' histiocytosis (PLCH), Birt-Hogg-Dubé syndrome (BHD), lymphoid interstitial pneumonia (LIP), and amyloidosis. A combination of clinical, radiological, and pathological approaches as well as genetic testing will clarify the diagnosis in most cases. LAM is a disease almost exclusively in women. Dyspnea, pneumothorax, and hemoptysis are common presentations in LAM patients. LAM is also a lymphatic disorder affecting lymphatic vessels and lymph nodes. Chylothorax, chylous ascites, and lymphangiomyomas are frequently seen. LAM can present sporadically as a single entity or as part of tuberous sclerosis complex (TSC). Angiomyolipoma (AML) is a characteristic extra-pulmonary lesion, either found in association with sporadic or TSC-related LAM. High-risk populations should be screened for LAM, including adult women with TSC and female patients with spontaneous pneumothorax, AMLs in the kidney, and diffuse cystic lung diseases. Definitive diagnosis of LAM is based on a high level of clinical suspicion on presentation supported by pathological findings or by a distinct feature, such as a history of TSC, AMLs in the kidney, chylothorax, or chylous ascites. Vascular endothelial growth factor-D (VEGF-D) in serum is a noninvasive and reliable diagnostic biomarker. In experienced centers, trans-bronchial lung biopsy (TBLB) provides a convenient and safe way to obtain lung specimens for diagnostic purposes. An effective treatment for LAM is now available, namely using a mechanistic target of rapamycin (mTOR) inhibitor such as sirolimus. Efficacy of sirolimus has been confirmed in clinical trials. Research in other molecular-targeted therapies is under investigation. A previously little-known rare disease with no cure is now better understood with regards to its pathogenesis, diagnosis, and management. In this review, current knowledge in diagnosis and differential diagnosis of LAM will be discussed, followed by the discussion of therapy with mTOR inhibitors.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1409
[Da] Date of entry for processing:140904
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2147/TCRM.S50784

  6 / 5502 MEDLINE  
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[PMID]: 25095320
[Au] Autor:Romero Maroto M; Ruiz Duque C; Vincent G; Garcia Recuero I; Romance A
[Ti] Title:Management of oral lesions in Lesch-Nyham syndrome.
[So] Source:J Clin Pediatr Dent;38(3):247-9, 2014.
[Is] ISSN:1053-4628
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Lesh-Nyhan Syndrome is a hereditary disorder that affects the way in which the body handles the production and breakdown of purines. One of its main characteristic is self-mutilation. We present a new appliance which allows healing to occur.
[Mh] MeSH terms primary: Bites, Human/prevention & control
Lesch-Nyhan Syndrome/complications
Lip/injuries
Self-Injurious Behavior/prevention & control
Tongue/injuries
[Mh] MeSH terms secundary: Child, Preschool
Follow-Up Studies
Humans
Male
Mouth Protectors
Occlusal Splints
Oral Hemorrhage/prevention & control
Oral Ulcer/prevention & control
Pacifiers
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:D
[Da] Date of entry for processing:140812
[St] Status:MEDLINE

  7 / 5502 MEDLINE  
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[PMID]: 25171628
[Au] Autor:Wysocka M; Cudzilo D; Kawala B; Kopczynski P
[Ad] Address:Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, Poland, magdalena.wysocka@imid.med.pl.
[Ti] Title:Eating habits of patients with cleft lip and palate terated with fixed appliances.
[So] Source:Dev Period Med;18(1):93-101, 2014.
[Is] ISSN:1428-345X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Health education, built on the basis of various models as a lifelong process, has a considerable impact on eating habits. Correct nutritional patterns are particularly important during the period of intense growth and adolescence. The need to observe dietary recommendations concerns healthy, as well as sick persons, especially those with chronic diseases. To-date the data on the dietary habits of patients with cleft lip and palate during orthodontic treatment have been scarce. OBJECTIVE OF THE STUDY: The objective of the study was to determine the eating habits of patients with cleft lip and palate before and during orthodontic treatment with a fixed appliance. MATERIAL AND METHOD: The study covered 125 patients with cleft lip and palate, aged 14 to 31. The research tool was an own questionnaire assessing the dietary behaviour and oral hygiene habits during the treatment with a fixed orthodontic appliance. RESULTS: In the course of the orthodontic treatment with a fixed appliance, 79 patients (57.6%) did not change their eating patterns and 32 patients (24%) changed them to a moderate degree. The mean of 53 patients (42.7%) changed their hygienic habits considerably. The number of meals remained the same, however in the period when patients suffered pain after orthodontic adjustment appointments, the number of persons having 4-5 meals a day decreased by 32%. It is worth considering that no statistically significant changes were recorded as regards the habit of having sweet snacks and the insufficient consumption of fruit and vegetables. Difficulties with correct oral hygiene were reported after the consumption of e.g. spinach (59.8%), cucumber (57.6%), berries (54.4%), meat (58.2%). CONCLUSIONS: Eating habits of a considerable percentage of patients with a cleft defect, before or during the treatment with a fixed appliance, do not comply with healthy nutrition recommendations. The dietary education of patients undergoing orthodontic treatment is necessary to ensure proper oral health and prevent diet-related illnesses.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 5502 MEDLINE  
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[PMID]: 25102688
[Au] Autor:Wang Y; Xu J; Guo R; Xu C; Hao Y; Chen C; Hong Y; Xiao X; Xu W; Hong J; Lei Z
[Ti] Title:Therapeutic effect in patients with coronary heart disease based on information analysis from traditional Chinese medicine four diagnostic methods.
[So] Source:J Tradit Chin Med;34(1):34-41, 2014 Feb.
[Is] ISSN:0255-2922
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To study information gained by Traditional Chinese Medicine (TCM) four diagnostic methods and characteristics of syndrome development before and after treatment in patients with coronary heart disease, and to probe into assessment indexes of therapeutic effects with distinctive TCM features. METHODS: Information from the four diagnostic methods before and after treatment in 100 patients with coronary heart disease was collected using the TCM interrogation scale, a pulse condition instrument, a tongue-face diagnosis instrument, and a voice diagnosis information collection system. Changes in the four diagnostic method results from before and after treatment were analyzed with frequency analysis and t-test methods. RESULTS: Before treatment, deficiency syndrome complicated with hyperactivity of pathogenic factors was most common. After treatment, deficiency syndrome was most common. This change from complex syndromes to single syndromes indicates disease and syndrome alleviation. Frequencies of symptoms gained by interrogation after treatment for syndrome of deficiency of heart-Qi, syndrome of deficiency of heart-Yin, and turbid phlegm syndrome were all less severe than those before treatment. Parameters of face color, color on all sub-regions of tongue, color of tongue fur, septic and greasy fur, and lip color after treatment all had significant changes. After treatment, part of the voice diagnosis parameters in the deficiency of heart-Yin and turbid phlegm syndromes had significant changes, but no significant changes were found in the deficiency of heart-Qi syndrome. CONCLUSION: Use of the TCM four diagnostic methods can provide an effective basis for TCM syndrome diagnosis, observation of development of state of illness, and evaluation of clinical therapeutic effects.
[Mh] MeSH terms primary: Coronary Disease/diagnosis
Coronary Disease/drug therapy
Drugs, Chinese Herbal/therapeutic use
[Mh] MeSH terms secundary: Diagnosis, Differential
Drugs, Chinese Herbal/adverse effects
Humans
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Drugs, Chinese Herbal)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140808
[St] Status:MEDLINE

  9 / 5502 MEDLINE  
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[PMID]: 23662656
[Au] Autor:Rajah K; Oliver MR; McLeod L; Orchard D; Leal M
[Ad] Address:Department of Gastroenterology, Royal Children's Hospital, Australia; Department of Paediatrics, Royal Children's Hospital, Australia.
[Ti] Title:Unusual manifestations of a common gastrointestinal disorder.
[So] Source:J Paediatr Child Health;50(2):158-60, 2014 Feb.
[Is] ISSN:1440-1754
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:We present an instructive case of a 13-year old male who presented with bilateral scrotal redness, swelling and tenderness, but with a normal testicular exam. His scrotal swelling persisted despite treatment with intravenous antibiotics, and on further history he reported 2 years of intermittent upper lip swelling. After a referral to a dermatologist, a lip biopsy showed granulomatous changes and he was referred to the gastroenterology department. A gastroscopy and colonoscopy was performed and histology confirmed non-caseating granulomas consistent with Crohn's disease (CD). Eighteen months after the diagnosis of CD he developed perianal disease with a fistula and distal anal stricture. He was successfully treated with insertion of a seton and escalation of therapy to azathioprine and infliximab. CD is a phenotypically diverse chronic inflammatory condition with an increasing incidence in Australia and other Western countries. Non-typical presentations, such as perianal manifestations or orofacial granulomatosis, can be the only presenting symptom in CD, and this highlights the importance for a high degree of clinical suspicion. Genital involvement is rare, but reported.
[Mh] MeSH terms primary: Crohn Disease/diagnosis
Granulomatosis, Orofacial/etiology
Scrotum/pathology
Testicular Diseases/etiology
[Mh] MeSH terms secundary: Adolescent
Crohn Disease/complications
Diagnosis, Differential
Edema/etiology
Humans
Magnetic Resonance Imaging
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140217
[St] Status:MEDLINE
[do] DOI:10.1111/jpc.12220

  10 / 5502 MEDLINE  
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[PMID]: 24124024
[Au] Autor:Kappen C
[Ti] Title:Modeling anterior development in mice: diet as modulator of risk for neural tube defects.
[So] Source:Am J Med Genet C Semin Med Genet;163C(4):333-56, 2013 Nov.
[Is] ISSN:1552-4876
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than 400 genes that contribute to proper neural tube closure have been identified in experimental animals, but only very few causative gene mutations have been identified in humans, supporting the notion that environmental influences are critical. The intrauterine environment is influenced by maternal nutrition, and hence, maternal diet can modulate the risk for cranial and neural tube defects. This article reviews recent progress toward a better understanding of nutrients during pregnancy, with particular focus on mouse models for defective neural tube closure. At least four major patterns of nutrient responses are apparent, suggesting that multiple pathways are involved in the response, and likely in the underlying pathogenesis of the defects. Folic acid has been the most widely studied nutrient, and the diverse responses of the mouse models to folic acid supplementation indicate that folic acid is not universally beneficial, but that the effect is dependent on genetic configuration. If this is the case for other nutrients as well, efforts to prevent neural tube defects with nutritional supplementation may need to become more specifically targeted than previously appreciated. Mouse models are indispensable for a better understanding of nutrient-gene interactions in normal pregnancies, as well as in those affected by metabolic diseases, such as diabetes and obesity.
[Mh] MeSH terms primary: Folic Acid/metabolism
Maternal Nutritional Physiological Phenomena
Morphogenesis
Neural Tube Defects/metabolism
[Mh] MeSH terms secundary: Anencephaly/genetics
Anencephaly/metabolism
Anencephaly/physiopathology
Animals
Cleft Lip/genetics
Cleft Lip/metabolism
Cleft Lip/physiopathology
Cleft Palate/complications
Cleft Palate/genetics
Cleft Palate/mortality
Diabetes, Gestational/genetics
Diabetes, Gestational/metabolism
Diabetes, Gestational/physiopathology
Dietary Supplements
Disease Models, Animal
Female
Gene-Environment Interaction
Humans
Mice
Neural Tube Defects/physiopathology
Pregnancy
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Name of substance:935E97BOY8 (Folic Acid)
[Em] Entry month:1405
[Cu] Class update date: 140901
[Lr] Last revision date:140901
[Js] Journal subset:IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.c.31380


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