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[PMID]: 24867649
[Au] Autor:Tollefson TT; Shaye D; Durbin-Johnson B; Mehdezadeh O; Mahomva L; Chidzonga M
[Ad] Address:Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, U.S.A.
[Ti] Title:Cleft lip-cleft palate in Zimbabwe: estimating the distribution of the surgical burden of disease using geographic information systems.
[So] Source:Laryngoscope;125 Suppl 1:S1-14, 2015 Feb.
[Is] ISSN:1531-4995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES/HYPOTHESIS: To evaluate the prevalence and unmet need for cleft lip-cleft palate reconstructive surgery by using incidence. Our hypotheses were that the age of presentation to screening clinics will decrease between 2006 and 2012, and the geospatial distribution of cases will expand to a more rural catchment area. STUDY DESIGN: Longitudinal cross-sectional/geospatial distribution study. METHODS: An online, secure database was created from intake forms for children with cleft lip-cleft palate (N=604) in Zimbabwe (2006-2012). Univariate analysis was completed. A linear regression model was fitted to test the time trend of a child's age at the time of presentation. Unique patient addresses (n=411) were matched. Maps presenting cleft diagnosis and presentation year were created with geographic information systems (GIS) software. RESULTS: The median age of presentation was greater for isolated cleft palate (4.2 years, n=106) than isolated cleft lip (1.5 years, n=251) and cleft lip-cleft palate (2.0 years, n=175). Cleft lip cases were mostly left sided with equal gender distribution. The overall age of presentation remained stable (P=.83). The age of children with isolated cleft palate decreased by 0.8 years per surgical trip (P=.01), suggesting the prevalence of unrepaired cleft palate is decreasing due to local and visiting surgeons. The catchment area extended to a less populous area, but clustered around Harare and Bulawayo. CONCLUSIONS: This study gives Zimbabwe-specific evidence that supports reports of the persistent burden of disease requiring attention. The GIS software provided data for the primary needs assessment, which will direct communication to healthcare providers and prospective patients outside of the current catchment area. LEVEL OF EVIDENCE: 3
[Mh] MeSH terms primary: Cleft Lip/epidemiology
Cleft Lip/surgery
Cleft Palate/epidemiology
Cleft Palate/surgery
Cost of Illness
Reconstructive Surgical Procedures/economics
[Mh] MeSH terms secundary: Child
Child, Preschool
Cleft Lip/diagnosis
Cleft Palate/diagnosis
Cross-Sectional Studies
Developing Countries
Female
Geographic Information Systems
Humans
Incidence
Infant
Linear Models
Longitudinal Studies
Male
Needs Assessment
Reconstructive Surgical Procedures/methods
Reconstructive Surgical Procedures/statistics & numerical data
Risk Assessment
Sex Distribution
Socioeconomic Factors
Zimbabwe/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:150124
[St] Status:MEDLINE
[do] DOI:10.1002/lary.24747

  2 / 5616 MEDLINE  
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[PMID]: 25511964
[Au] Autor:Lemound J; Stoetzer M; Kokemüller H; Schumann P; Gellrich NC
[Ad] Address:Resident, Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany. Electronic address: Lemound.Juliana@mh-hannover.de....
[Ti] Title:Modified technique for rehabilitation of facial paralysis using autogenous fascia lata grafts.
[So] Source:J Oral Maxillofac Surg;73(1):176-83, 2015 Jan.
[Is] ISSN:1531-5053
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: In this retrospective study we used a modified surgical technique for midface reanimation in patients with facial nerve paralysis. Facial atonicity can cause functional impairment regarding speech articulation, oral competence, breathing, and eyelid closure. Furthermore, esthetic and psychological aspects play an important role in patients' emotional interaction and social integration. The chosen rehabilitative technique should offer support against prolapse of facial structures and remedy of functional disabilities and, thereby, prevention of social stigmatization due to disease-related changes in appearance. MATERIALS AND METHODS: Between 2005 and 2013, fascia lata grafts were used as static support in 15 cases of unilateral facial paralysis. Two fascia lata grafts were subcutaneously inserted in the upper and lower lips crossing the midline and sutured at 4 points, including the unaffected part of the orbicularis oris muscle and modiolus. The slings were suspended against the zygomatic arch with an osteosynthesis plate. RESULTS: The patients perceived surgery results as considerably improving their appearance, speech, and alimentation. In 93.3% of cases, no postoperative complications occurred. The follow-up results (8 months to 8 years) remained stable. CONCLUSIONS: This retrospective study showed the advantages of static facial reanimation in appropriate cases. The bony fixated support of the fascial slings allows an immediate improvement of facial symmetry. Additional attachment points including the unaffected part of the orbicularis oris muscle and the use of 2 independent fascia lata slings allow a more accurate adjustment of suspension forces and an incomplete dynamic reanimation of the mouth corner. With respect to its simplicity and minimal invasiveness, this surgical procedure is associated with low morbidity and rapid improvement of the patient's esthetic appearance.
[Mh] MeSH terms primary: Autografts/transplantation
Facial Paralysis/surgery
Fascia Lata/transplantation
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Bone Plates
Emotions
Esthetics
Eyelids/physiology
Facial Muscles/surgery
Facial Nerve Diseases/surgery
Female
Follow-Up Studies
Humans
Interpersonal Relations
Lip/surgery
Male
Middle Aged
Mouth/physiology
Mouth/surgery
Respiration
Retrospective Studies
Speech/physiology
Treatment Outcome
Young Adult
Zygoma/surgery
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:AIM; D; IM
[Da] Date of entry for processing:141216
[St] Status:MEDLINE

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[PMID]: 25780538
[Au] Autor:Naik SM; Naik SS
[Ad] Address:Dept. of ENT, Head and Neck Surgery, KVG Medical College, Sullia, India.
[Ti] Title:A study of 63 cases of mouth neoplasms in arecanut growing belt of sullia.
[So] Source:Iran J Cancer Prev;5(1):39-45, 2012.
[Is] ISSN:2008-2398
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Betel nut and betel quid chewing are from major etiological factor for oral cancer. They also increase the risk of systemic diseases such as asthma, diabetes mellitus, metabolic syndrome, myocardial infarction, hypertension, and other cardiovascular diseases. METHODS: Sixty three patients of oral cancer in our institution during Jan. 2007 to May 2011 were included in our study. This study included 14 cases of lip carcinoma, 41 cases of buccal mucosa carcinoma, 7 cases of tongue carcinoma, and 1 case of carcinoma of upper alveolus. Duration of use of betel quid, pan masala, and gutkha were studied as well as management. RESULTS: All patients in our study have been chewing betel-quid for 6-31 years (mean19.42 years). All of them quit betel quid and used easily available panmasala and gutkha for 4-13 years (mean 8.28 years). Nine cases of lip carcinoma, 13 cases of buccal mucosa carcinoma and 3 cases of tongue carcinoma were treated with surgery. Seven cases of lip carcinoma, 30 cases of buccal mucosa carcinoma and 5 cases of tongue carcinoma were treated with post operative or palliative radiotherapy. CONCLUSION: Betel nut chewing with or without tobacco and lime are proven to be carcinogens in human. Direct relationship between oral cancer and betel quid, gutkha, and panmasala use has been shown in our study. As betel quid, panmasala and gutkha chewing were proven to be carcinogens, a permanent ban on manufacturing and sale of these products should be implemented.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Da] Date of entry for processing:150317
[St] Status:PubMed-not-MEDLINE

  4 / 5616 MEDLINE  
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[PMID]: 25391604
[Au] Autor:Simioni M; Araujo TK; Monlleo IL; Maurer-Morelli CV; Gil-da-Silva-Lopes VL
[Ad] Address:Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil....
[Ti] Title:Investigation of genetic factors underlying typical orofacial clefts: mutational screening and copy number variation.
[So] Source:J Hum Genet;60(1):17-25, 2015 Jan.
[Is] ISSN:1435-232X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Typical orofacial clefts (OFCs) comprise cleft lip, cleft palate and cleft lip and palate. The complex etiology has been postulated to involve chromosome rearrangements, gene mutations and environmental factors. A group of genes including IRF6, FOXE1, GLI2, MSX2, SKI, SATB2, MSX1 and FGF has been implicated in the etiology of OFCs. Recently, the role of the copy number variations (CNVs) has been studied in genetic defects and diseases. CNVs act by modifying gene expression, disrupting gene sequence or altering gene dosage. The aims of this study were to screen the above-mentioned genes and to investigate CNVs in patients with OFCs. The sample was composed of 23 unrelated individuals who were grouped according to phenotype (associated with other anomalies or isolated) and familial recurrence. New sequence variants in GLI2, MSX1 and FGF8 were detected in patients, but not in their parents, as well as in 200 control chromosomes, indicating that these were rare variants. CNV screening identified new genes that can influence OFC pathogenesis, particularly highlighting TCEB3 and KIF7, that could be further analyzed. The findings of the present study suggest that the mechanism underlying CNV associated with sequence variants may play a role in the etiology of OFC.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/jhg.2014.96

  5 / 5616 MEDLINE  
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[PMID]: 25642946
[Au] Autor:Pereira L; Abbehusen M; Teixeira C; Cunha J; Nascimento IP; Fukutani K; dos-Santos W; Barral A; de Oliveira CI; Barral-Netto M; Soto M; Brodskyn CI
[Ad] Address:Centro de Pesquisa Gonçalo Moniz, FIOCRUZ-BA, Bahia, Brazil....
[Ti] Title:Vaccination with Leishmania infantum acidic ribosomal P0 but not with nucleosomal histones proteins controls Leishmania infantum infection in hamsters.
[So] Source:PLoS Negl Trop Dis;10(2):e0003490, 2015 Feb.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Several intracellular Leishmania antigens have been identified in order to find a potential vaccine capable of conferring long lasting protection against Leishmania infection. Histones and Acid Ribosomal proteins are already known to induce an effective immune response and have successfully been tested in the cutaneous leishmaniasis mouse model. Here, we investigate the protective ability of L. infantum nucleosomal histones (HIS) and ribosomal acidic protein P0 (LiP0) against L. infantum infection in the hamster model of visceral leishmaniasis using two different strategies: homologous (plasmid DNA only) or heterologous immunization (plasmid DNA plus recombinant protein and adjuvant). METHODOLOGY/PRINCIPAL FINDINGS: Immunization with both antigens using the heterologous strategy presented a high antibody production level while the homologous strategy immunized group showed predominantly a cellular immune response with parasite load reduction. The pcDNA-LiP0 immunized group showed increased expression ratio of IFN-γ/IL-10 and IFN-γ/TGF-ß in the lymph nodes before challenge. Two months after infection hamsters immunized with the empty plasmid presented a pro-inflammatory immune response in the early stages of infection with increased expression ratio of IFN-γ/IL-10 and IFN-γ/TGF-ß, whereas hamsters immunized with pcDNA-HIS presented an increase only in the ratio IFN-γ/ TGF-ß. On the other hand, hamsters immunized with LiP0 did not present any increase in the IFN-γ/TGF-ß and IFN-γ/IL-10 ratio independently of the immunization strategy used. Conversely, five months after infection, hamsters immunized with HIS maintained a pro-inflammatory immune response (ratio IFN-γ/ IL-10) while pcDNA-LiP0 immunized hamsters continued showing a balanced cytokine profile of pro and anti-inflammatory cytokines. Moreover we observed a significant reduction in parasite load in the spleen, liver and lymph node in this group compared with controls. CONCLUSIONS/SIGNIFICANCE: Our results suggest that vaccination with L. infantum LiP0 antigen administered in a DNA formulation could be considered a potential component in a vaccine formulation against visceral leishmaniasis.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1502
[Cu] Class update date: 150213
[Lr] Last revision date:150213
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1371/journal.pntd.0003490

  6 / 5616 MEDLINE  
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[PMID]: 25591580
[Au] Autor:Johkoh T; Fukuoka J; Tanaka T
[Ad] Address:Department of Radiology, Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Japan. Electronic address: johkoht@aol.com.
[Ti] Title:Rare idiopathic intestinal pneumonias (IIPs) and histologic patterns in new ATS/ERS multidisciplinary classification of the IIPs.
[So] Source:Eur J Radiol;84(3):542-6, 2015 Mar.
[Is] ISSN:1872-7727
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:The new American Thoracic Society/European Respiratory Society (ATS/ERS) update to the multidisciplinary classification of idiopathic interstitial pneumonias (IIPs) defines both rare IIPs and rare histologic patterns of IIPs. Although these diseases are rare, each has some distinguishing imaging and pathologic characteristics. Common findings for IIPs in computed tomography (CT) include cysts in lymphoid interstitial pneumonia (LIP), upper lobe subpleural consolidation in pleuropulmonary fibroelastosis (PPFE), symmetrical consolidation in acute fibrinous organizing pneumonia (AFOP), and peribronchovascular consolidation or centrilobular nodules in bronchiolocentric pattern of interstitial pneumonia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 5616 MEDLINE  
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[PMID]: 25612455
[Au] Autor:Li M; Ma K; Shan J
[Ti] Title:[Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis].
[So] Source:Zhongguo Zhong Yao Za Zhi;39(19):3860-4, 2014 Oct.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: In this study, the clinical data of 240 cases of data acquisition on ovulation in patients with anovulatory infertility. METHOD: Using the method of factor analysis, summed up the distribution situation of various syndromes and the relationship of disease-syndrome-symptom. RESULT: From the study we found that polycystic ocary syndrome > premature ovarian failure > corpus luteum insufficiency > luteinized unruptured follicle syndrome > hyperprolactinemia > anovulatory dysfunctional uterine bleeding. Using the factor analysis method, the syndromes of anovulatory infertility were divided into six types and the distribution proportion of them is: kidney Yang deficiency and blood stasis > kidney Yang deficiency > kidney Yin deficiency and blood stasis > kidney Yin deficiency and liver Qi stagnation syndrome > kidney Yang deficiency and phlegm dampness stagnation > kidney Yin deficiency. By means of statistics, the traditional Chinese medicine (TCM) symptoms as abdomen pain before menstrual onset, obfuscation colour, cold lower abdomen, insomnia, fatigue, eyes dark, face dark or ring lip dark, before and after menstruation breast swelling, chest tightness, irritable insomnia, depression and lower abdomen pain during menstruation etc contribute high degree in the process. CONCLUSION: Polycystic ovary syndrome and premature are the main causes of ovulatory disorder infertility and the disease incidence rate assumed the tendency which rose year by year. The treatment of the disease of kidney yang deficiency syndrome scales biggest the disease degree of contribution. Blood stasis is the important factor in the process of pathogenesis evolution. In the study of disease distribution, we found that symptom distribution trend roughly the same and the same symptom severity in different diseases with different, which provides experience for the theory-different diseases with the same therapeutic method. These conclusions provide guidance and reference evidences for clinic practice.
[Mh] MeSH terms primary: Infertility, Female/diagnosis
Ovulation
[Mh] MeSH terms secundary: Adult
Diagnosis, Differential
Female
Humans
Infertility, Female/physiopathology
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:150123
[St] Status:MEDLINE

  8 / 5616 MEDLINE  
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[PMID]: 25714165
[Au] Autor:Unizony SH; Kim ND; Hoang MP
[Ti] Title:Case Records of the Mass General Hospital. Case 7-2015: A 25-year-old man with oral ulcers, rash, and odynophagia.
[So] Source:N Engl J Med;372(9):864-72, 2015 Feb 26.
[Is] ISSN:1533-4406
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed.
[Mh] MeSH terms primary: Behcet Syndrome/pathology
Hair Follicle/pathology
Lip/pathology
Oral Ulcer/etiology
[Mh] MeSH terms secundary: Adult
Behcet Syndrome/complications
Deglutition Disorders/etiology
Diagnosis, Differential
Exanthema/etiology
Folliculitis/etiology
Folliculitis/pathology
Genital Diseases, Male/etiology
Humans
Male
Sexually Transmitted Diseases/diagnosis
Skin Diseases/diagnosis
[Pt] Publication type:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150226
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1413303

  9 / 5616 MEDLINE  
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[PMID]: 25365223
[Au] Autor:Perino A; Pols TW; Nomura M; Stein S; Pellicciari R; Schoonjans K
[Ti] Title:TGR5 reduces macrophage migration through mTOR-induced C/EBPß differential translation.
[So] Source:J Clin Invest;124(12):5424-36, 2014 Dec.
[Is] ISSN:1558-8238
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of macrophage-specific TGR5 signaling in protecting adipose tissue from inflammation and associated insulin resistance. Examination of adipose tissue from obese mice lacking macrophage Tgr5 revealed enhanced inflammation, increased chemokine expression, and higher macrophage numbers compared with control obese animals. Moreover, macrophage-specific deletion of Tgr5 exacerbated insulin resistance in obese animals. Conversely, pharmacological activation of TGR5 markedly decreased LPS-induced chemokine expression in primary macrophages. This reduction was mediated by AKT-dependent activation of mTOR complex 1, which in turn induced the differential translation of the dominant-negative C/EBPß isoform, liver inhibitory protein (LIP). Overall, these studies reveal a signaling pathway downstream of TGR5 that modulates chemokine expression in response to high-fat diet and suggest that targeting this pathway has the potential to be therapeutically exploited for prevention of chronic inflammatory diseases and type 2 diabetes mellitus.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1412
[Cu] Class update date: 150309
[Lr] Last revision date:150309
[Js] Journal subset:AIM; IM
[St] Status:In-Process

  10 / 5616 MEDLINE  
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[PMID]: 21801088
[Au] Autor:Hak MS; Sasaguri M; Sulaiman FK; Hardono ET; Suzuki A; Nakamura S; Ohishi M
[Ad] Address:Cleft Center, Harapan Kita Children and Maternity Hospital, Jakarta, Indonesia.
[Ti] Title:Longitudinal study of effect of Hotz's Plate and lip adhesion on maxillary growth in bilateral cleft lip and palate patients.
[So] Source:Cleft Palate Craniofac J;49(2):230-6, 2012 Mar.
[Is] ISSN:1545-1569
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate the effects of infant orthopedic treatment and lip adhesion on maxillary growth of patients with bilateral cleft lip and palate (BCLP). DESIGN: Prospective longitudinal study. SETTING: The present study was conducted at the Cleft Lip and Palate Center, Harapan Kita Children and Maternity Hospital, Indonesia, and the Department of Oral and Maxillofacial Surgery, Kyushu University Hospital, Japan. SUBJECTS: The study sample consisted of 53 patients with complete BCLP and 10 noncleft patients with other diseases. Patients with BCLP were divided into three groups: H (-), 11 patients treated without Hotz's plate; H (+), 24 treated with Hotz's plate; and LA-H, 18 treated with lip adhesion and Hotz's plate. METHODS: Serial dental casts were obtained from each BCLP child at the following four time points: first visit, labioplasty, palatoplasty, and 5 years of age. Each maxillary dental cast was scanned, and the linear and angular dimensions were measured. RESULTS AND CONCLUSION: Lip adhesion showed a temporary negative effect. In all patients with BCLP, the surgeries affected the growth of the anterior arch width until the age of 5 years. Collapse of the premaxilla following labioplasty in the H (-) group affected the growth of dental arch length until the age of 5 years. Treatment using Hotz's plate prevented collapse of the premaxilla, and the growth of the arch length was comparable to that observed in the noncleft group.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1203
[Js] Journal subset:D; IM
[St] Status:In-Process
[do] DOI:10.1597/10-042


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