Database : MEDLINE
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[PMID]: 26960872
[Au] Autor:Füeßl HS
[Ad] Address:.
[Ti] Title:Morbus Crohn beim Zahnarzt. [Crohn's disease at the dentist].
[So] Source:MMW Fortschr Med;157(21-22):54, 2015 Dec 14.
[Is] ISSN:1438-3276
[Cp] Country of publication:Germany
[La] Language:ger
[Mh] MeSH terms primary: Crohn Disease/diagnosis
Gingival Diseases/diagnosis
Lip Diseases/diagnosis
[Mh] MeSH terms secundary: Adolescent
Biopsy
Crohn Disease/pathology
Diagnosis, Differential
Gingiva/pathology
Gingival Diseases/pathology
Granulation Tissue/pathology
Humans
Intestinal Mucosa/pathology
Male
[Pt] Publication type:CASE REPORTS; NEWS
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:160310
[St] Status:MEDLINE
[do] DOI:10.1007/s15006-015-7619-5

  2 / 5364 MEDLINE  
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[PMID]: 23615783
[Au] Autor:Kapoor K; Saha A; Dubey NK
[Ad] Address:Division of Pediatric Nephrology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research Associated Dr Ram Manohar Lohia Hospital, Room No 406, PGIMER Building, New Delhi, 201010, India.
[Ti] Title:Lip hypertrophy due to cyclosporine therapy.
[So] Source:Clin Exp Nephrol;18(1):168-9, 2014 Feb.
[Is] ISSN:1437-7799
[Cp] Country of publication:Japan
[La] Language:eng
[Mh] MeSH terms primary: Cyclosporine/adverse effects
Immunosuppressive Agents/adverse effects
Lip Diseases/chemically induced
Lip/drug effects
Nephrotic Syndrome/congenital
[Mh] MeSH terms secundary: Child, Preschool
Cyclosporine/administration & dosage
Drug Substitution
Humans
Hypertrophy
Immunosuppressive Agents/administration & dosage
Lip/pathology
Lip Diseases/diagnosis
Male
Nephrotic Syndrome/diagnosis
Nephrotic Syndrome/drug therapy
Remission Induction
Tacrolimus/administration & dosage
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunosuppressive Agents); 83HN0GTJ6D (Cyclosporine); WM0HAQ4WNM (Tacrolimus)
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:140213
[St] Status:MEDLINE
[do] DOI:10.1007/s10157-013-0808-6

  3 / 5364 MEDLINE  
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[PMID]: 27082957
[Au] Autor:Schupp JC; Köhler T; Müller-Quernheim J
[Ad] Address:Department of Pneumology, University Medical Centre, Albert Ludwig University, Freiburg, Germany.
[Ti] Title:Usefulness of Cyclophosphamide Pulse Therapy in Interstitial Lung Diseases.
[So] Source:Respiration;91(4):296-301, 2016.
[Is] ISSN:1423-0356
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Interstitial lung diseases (ILDs) are a group of disorders characterised by progressive lung function decline. Stabilisation of lung function under intermittent i.v. cyclophosphamide was shown in patients suffering from systemic sclerosis, yet data in ILD patients are scarce. OBJECTIVES: To retrospectively evaluate the usefulness of cyclophosphamide pulse therapy in ILD. METHODS: We retrospectively analysed all patients who received i.v. cyclophosphamide in our centre from 2002 to 2012. Lung function, survival status, and bronchoalveolar lavage cytology were recorded during a follow-up period of 18 months. RESULTS: Twenty-six patients with idiopathic pulmonary fibrosis, 6 with lymphocytic interstitial pneumonia (LIP), 8 with idiopathic non-specific interstitial pneumonia (NSIP), 7 with rheumatoid arthritis-associated ILD, and 7 with perinuclear anti-neutrophil cytoplasmic antibody-positive ILD (pANCA+ ILD) were included. Patients with LIP and NSIP had the best survival outcome, those with pANCA+ ILD the worst. In the total cohort, we found a significantly higher total lung capacity decline in the year before treatment compared to the year after treatment. CONCLUSIONS: This retrospective analysis of cyclophosphamide treatment shows a stabilisation of lung function in most patients with fibrotic ILDs, yet prospective studies in clearly defined diagnoses are urgently needed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1159/000445031

  4 / 5364 MEDLINE  
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[PMID]: 25541097
[Au] Autor:Moscovich M; Chen ZP; Rodriguez R
[Ad] Address:Department of Neurology, University of Florida, Center for Movement Disorders & Neurorestoration, McKnight Brain Institute, 3450 Hull Road, 4th floor, Gainesville, FL 32607, USA.
[Ti] Title:Successful treatment of open jaw and jaw deviation dystonia with botulinum toxin using a simple intraoral approach.
[So] Source:J Clin Neurosci;22(3):594-6, 2015 Mar.
[Is] ISSN:1532-2653
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:Oromandibular dystonia (OMD) is a focal dystonia that involves the mouth, jaw, and/or tongue. It can be classified as idiopathic, tardive dystonia or secondary to other neurological disorders and subdivided into jaw opening, jaw closing, jaw deviation and lip pursing. The muscles involved in jaw opening dystonia are usually the digastrics and lateral pterygoids. It is known that the lateral pterygoids may be approached both internally and externally. The external approach is the most common; however neurologists experienced in treating patients with botulinum toxin can safely and with no extra cost perform the intraoral procedure. We report our experience in the treatment of jaw opening and jaw deviation dystonia using the intraoral injection approach. Eight patients were selected from the University of Florida with a clinical diagnosis of open jaw/jaw deviation dystonia. All of them were injected with onabotulinum toxin A using the internal approach and the clinical global impression scale was applied. The mean age of the patients was 67 (standard deviation [SD] 10.2) years, with a disease duration of 10.2 (SD 7.7) years and the mean distance they traveled to our institution was 448 km (278 miles). After treatment, six patients scored as very much improved in the clinical global impression scale and two patients scored as much improved. Only one patient reported an adverse event of nasal speech following one of the injections that improved after 4 weeks. Botulinum toxin injections for open jaw/jaw deviation dystonia can be safely performed with the intraoral approach without the need of special devices other than electromyography.
[Mh] MeSH terms primary: Botulinum Toxins, Type A/therapeutic use
Dystonic Disorders/drug therapy
Jaw Diseases/drug therapy
[Mh] MeSH terms secundary: Aged
Electromyography
Female
Humans
Male
Middle Aged
Neck Muscles
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (onabotulinumtoxinA); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:150210
[St] Status:MEDLINE

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[PMID]: 26654640
[Au] Autor:Arslan S; Çobanoglu B; Ural A; Saygin I; Isik AÜ
[Ad] Address:Department of Otorhinolaryngology,School of Medicine,Karadeniz Technical University,Trabzon,Turkey....
[Ti] Title:A 15-year retrospective study of 160 cases of benign lip lesions.
[So] Source:J Laryngol Otol;129(12):1224-7, 2015 Dec.
[Is] ISSN:1748-5460
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This study aimed to describe the results of a retrospective analysis of a specific cohort of patients with benign lip lesions encountered in the last 15 years in the School of Medicine at Karadeniz Technical University. METHOD: A total of 312 patients were managed for lip lesions during the period 2000-2014. Data from 160 samples of benign lip biopsies were retrieved from the pathology laboratory records. RESULTS: The study group included 20 different histopathological types of lesions, with mucocele being the most frequent lesion (43.13 per cent). The other frequent lesions were chronic inflammatory infiltrate (11.25 per cent), intradermal naevus (5.63 per cent), pyogenic granuloma (5.63 per cent), fibroma (5 per cent) and papilloma (5 per cent). Mucocele was significantly more common in younger patients (p < 0.001). CONCLUSION: Knowledge of the epidemiology and distribution of oral mucosal lesions is essential to promote early diagnosis and treatment. Further epidemiological studies exploring the causal relationships and risk factors for lip lesions are necessary for a better understanding of lip diseases.
[Mh] MeSH terms primary: Lip Neoplasms/epidemiology
Lip Neoplasms/pathology
Lip/pathology
[Mh] MeSH terms secundary: Adult
Age Distribution
Aged
Aged, 80 and over
Biopsy, Needle
Cohort Studies
Databases, Factual
Female
Humans
Immunohistochemistry
Incidence
Lip Diseases/epidemiology
Lip Diseases/pathology
Lip Diseases/physiopathology
Male
Middle Aged
Mouth Mucosa/pathology
Prognosis
Retrospective Studies
Risk Assessment
Sex Distribution
Time Factors
Turkey/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:151215
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215115002923

  6 / 5364 MEDLINE  
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[PMID]: 26530049
[Au] Autor:Nowak JK; Grulkowski I; Karnowski K; Wojtkowski M; Walkowiak J
[Ad] Address:Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland....
[Ti] Title:Optical Coherence Tomography of the Labial Salivary Glands Reveals Age-Related Differences in Women.
[So] Source:Clin Transl Sci;8(6):717-21, 2015 Dec.
[Is] ISSN:1752-8062
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The labial minor salivary glands (LSGs) play a role in medical research and practice due to their superficial location and involvement in both systemic and localized diseases. Swept-source optical coherence tomography (OCT) is a noninvasive modality that enables in vivo, micrometer resolution, wide-field three-dimensional imaging in seconds. A purpose-built swept-source OCT instrument was employed to acquire three-dimensional datasets covering the area of 2.43 cm(2) of the mucosa of the lower lip to the depth of 3.4 mm in young (n = 14; mean age ± SD: 27 ± 3 years; body mass index [BMI] 20.4 ± 2.3 kg/m(2) ) and middle-aged women (n = 11; 54 ± 6 years; 25.5 ± 3.2 kg/m(2) ). Glandular tissue reflectivity mode (range 0-255; 86 ± 17 vs. 68 ± 12, p = 0.005), average single LSG area in tissue sample (5.26 ± 2.62 mm(2) vs. 2.87 ± 1.26 mm(2) , p = 0.011), and LSG surface filling factor (0.23 ± 0.13 vs. 0.11 ± 0.10, p = 0.027) had higher values in younger than in middle-aged women. A correlation between BMI and glandular tissue reflectivity mode (Spearman's ρ = -0.60) was found (p = 0.002). The results highlight the potential value of LSGs' OCT morphometry in research regarding ageing.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/cts.12344

  7 / 5364 MEDLINE  
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[PMID]: 26964398
[Au] Autor:Doi K; Kanzaki S; Kumakawa K; Usami S; Iwasaki S; Yamanaka N; Naito Y; Gyo K; Tono T; Takahashi H; Kanda Y
[Ti] Title:[Evaluation of the Effectiveness and Safety in a Multi-center Clinical Trial of VIBRANT SOUNDBRIDGE in Japan].
[So] Source:Nihon Jibiinkoka Gakkai Kaiho;118(12):1449-58, 2015 Dec.
[Is] ISSN:0030-6622
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:Middle ear implants (MEIs) such as the Vibrant Soundbridge (VSB) are attractive and alternative treatments for patients with conductive, sensorineural, and mixed hearing loss who do not benefit from, or who choose not to wear, conventional hearing aids (HAs). Recent studies suggest that MEIs can provide better improvements in functional gain, speech perception, and quality of life than HAs, although there are certain risks associated with the surgery which should be taken into consideration, including facial nerve or chorda tympanic nerve damage, dysfunctions of the middle and inner ears, and future device failure/explantation. In Japan, a multi-center clinical trial of VSB was conducted between 2011-2014. A round window vibroplasty via the transmastoid approach was adopted in the protocol. The bony lip overhanging the round window membrane (RWM) was extensively but very carefully drilled to introduce the Floating Mass Transducer (FMT). Perichondrium sheets were used to stabilize the FMT onto the RWM. According to the audiological criteria, the upper limit of bone conduction should be 45 dB, 50 dB, and 65 dB from 500 Hz to 4, 000 Hz. Twenty-five patients underwent the surgery so far at 13 different medical centers. The age at the surgery was between 26-79 years old, and there were 15 males and 10 females. The cause of conductive or mixed hearing loss was middle ear diseases in 23 cases and congenital aural atresia in two cases. The data concerning on the effectiveness and safety of VSB was collected before the surgery and 20 weeks after the surgery. Significant improvements of free-field Pure Tone Audiogram (PTA) from 250 Hz to 8, 000 Hz were confirmed (p < 0.001). Hearing gain up to 40 dB was achieved in the 1, 000 Hz to 4, 000 Hz range. No deterioration in either air conduction or bone conduction at PTA was noted at 20 weeks after the surgery. Monosyllable speech perception in both quiet and noisy conditions improved significantly (p < 0.001). The speech discrimination score in both quiet and noisy conditions improved significantly too (p < 0.001). In the future, it is likely that there will be an increasing population even in Japan that will meet the criteria for MEIs such as VSB. However, the long-term efficacy and safety of these devices should be established.
[Mh] MeSH terms primary: Hearing Aids
[Mh] MeSH terms secundary: Adult
Aged
Auditory Threshold
Equipment Design
Female
Humans
Japan
Male
Middle Aged
[Pt] Publication type:CLINICAL TRIAL; ENGLISH ABSTRACT; JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:160311
[St] Status:MEDLINE

  8 / 5364 MEDLINE  
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[PMID]: 26910021
[Au] Autor:Fernandes G; Franco-Micheloni AL; Siqueira JT; Gonçalves DA; Camparis CM
[Ad] Address:Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, SP, Brazil....
[Ti] Title:Parafunctional habits are associated cumulatively to painful temporomandibular disorders in adolescents.
[So] Source:Braz Oral Res;30, 2016.
[Is] ISSN:1807-3107
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:This cross-sectional study was designed to evaluate the effect of sleep bruxism, awake bruxism and parafunctional habits, both separately and cumulatively, on the likelihood of adolescents to present painful TMD. The study was conducted on a sample of 1,094 adolescents (aged 12-14). The presence of painful TMD was assessed using the Research Diagnostic Criteria for Temporomandibular Disorders, Axis I. Data on sleep bruxism, awake bruxism and parafunctional habits (nail/pen/pencil/lip/cheek biting, resting one's head on one's hand, and gum chewing) were researched by self-report. After adjusting for potential demographic confounders using logistic regression, each of the predictor variables (sleep bruxism, awake bruxism and parafunctional habits) was significantly associated with painful TMD. In addition, the odds for painful TMD were higher in the concomitant presence of two (OR=4.6, [95%CI=2.06, 10.37]) or three predictor (OR=13.7, [95%CI=5.72, 32.96]) variables. These findings indicate that the presence of concomitant muscle activities during sleep and awake bruxism and parafunctional habits increases the likelihood almost linearly of adolescents to present painful TMD.
[Mh] MeSH terms primary: Bruxism/physiopathology
Facial Pain/physiopathology
Habits
Temporomandibular Joint Disorders/physiopathology
[Mh] MeSH terms secundary: Adolescent
Brazil
Chewing Gum/adverse effects
Epidemiologic Methods
Female
Humans
Male
Masticatory Muscles/physiopathology
Pain Measurement
Risk Factors
Sex Factors
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Chewing Gum)
[Em] Entry month:1605
[Js] Journal subset:D; IM
[Da] Date of entry for processing:160225
[St] Status:MEDLINE

  9 / 5364 MEDLINE  
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[PMID]: 25566770
[Au] Autor:Morsy K; Bashtar AR; Mostafa N; El Deeb S; Thabet S
[Ad] Address:Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt, kareemsaid156@yahoo.com.
[Ti] Title:New host records of three juvenile nematodes in Egypt: Anisakis sp. (Type II), Hysterothylacium patagonense (Anisakidae), and Echinocephalus overstreeti (Gnathostomatidae) from the greater lizard fish Saurida undosquamis of the Red Sea.
[So] Source:Parasitol Res;114(3):1119-28, 2015 Mar.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Three juvenile nematode parasites were collected naturally from 90 (75 %) out of 120 specimens of the marine greater lizard fish Saurida undosquamis captured from water coasts at Hurghada City along the Red Sea in Egypt during the period from September 2013 to April 2014. Worms were identified on the basis of light and scanning electron microscopy. Two of the recovered worms were isolated from the peritoneal cavity of the infected fish around the wall of the stomach as encapsulated larvae. The anisakid juvenile Anisakis sp. (Type II) was characterized by an anteroventrally triangular mouth, with a boring tooth; its postanal tail was rounded, without a terminal mucron or spine. The gnathostomatid Echinocephalus overstreeti was characterized by the presence of a cephalic bulb armed with six transverse rows of spines which were slightly more compact near the anterior end of bulb with maximal separation near the midbulb; the cephalic bulb terminated at a pseudolabia which situated dorsoventrally and reached its greatest width at the posterior one third of the body, The postanal tail terminated at a pointed mucron. The third juvenile species, Hysterothylacium patagonense (Anisakidae), was isolated from the intestine of the infected fish; they are characterized by a small-sized body with a conical tail provided by a nodulose apex, and the anterior end was equipped with three lips. A dorsal lip slightly smaller than the two subventrals left a deep postlabial groove and prominent lateral flanges in between, and the proximal part of each lip was smooth. The three described species were compared morphologically and morphometrically with some of the previously recorded species of the same genus. From this comparison, the similarity and variations between these species were described and concluded that the present study should be considered as a new host record in Egypt.
[Mh] MeSH terms primary: Anisakis/classification
Ascaridida Infections/veterinary
Ascaridoidea/classification
Fish Diseases/parasitology
Spirurida Infections/veterinary
Spirurida/classification
[Mh] MeSH terms secundary: Animals
Anisakis/cytology
Anisakis/isolation & purification
Ascaridida Infections/epidemiology
Ascaridida Infections/parasitology
Ascaridoidea/cytology
Ascaridoidea/isolation & purification
Egypt/epidemiology
Female
Fish Diseases/epidemiology
Fishes
Indian Ocean/epidemiology
Intestines/parasitology
Larva
Male
Microscopy, Electron, Scanning/veterinary
Spirurida/cytology
Spirurida/isolation & purification
Spirurida Infections/epidemiology
Spirurida Infections/parasitology
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:150221
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-014-4285-y

  10 / 5364 MEDLINE  
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[PMID]: 26215833
[Au] Autor:Hozyasz KK; Mostowska A; Wójcicki P; Lasota A; Zadurska M; Dunin-Wilczynska I; Jagodzinski PP
[Ad] Address:Department of Paediatrics, Institute of Mother and Child, 17a Kasprzaka Str., 01-211, Warsaw, Poland. khozyasz@verco.com.pl....
[Ti] Title:Nucleotide Variants of the BH4 Biosynthesis Pathway Gene GCH1 and the Risk of Orofacial Clefts.
[So] Source:Mol Neurobiol;53(1):769-76, 2016 Jan.
[Is] ISSN:1559-1182
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A deficiency of GTP cyclohydrolase, encoded by the GCH1 gene, results in two neurological diseases: hyperphenylalaninaemia type HPABH4B and DOPA-responsive dystonia. Genes involved in neurotransmitter metabolism and motor systems may contribute to palatogenesis. The purpose of the study was to analyse polymorphic variants of the GCH1 gene as risk factors for non-syndromic cleft lip with or without cleft palate (NSCL/P). Genotyping of nine polymorphisms was conducted in a group of 281 NSCL/P patients and 574 controls. The GCH1 variant rs17128077 was associated with a 1.7-fold higher risk for NSCL/P (95 %CI = 1.224-2.325; p = 0.001). We also found a significant correlation between the rs8004018 and rs17128050 variants and an increased risk of oral clefts (p trend = 0.003 and 0.004, respectively). The best evidence of the global haplotype association was observed for rs17128050 and rs8004018 (p corr = 0.0152). This study demonstrates that the risk of NSCL/P is associated with variants of the GCH1 gene related to BH4 metabolism and provides some evidence of the relationships between morphological/functional shifts in the central nervous system and orofacial clefts.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1601
[Cu] Class update date: 160113
[Lr] Last revision date:160113
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s12035-015-9342-8


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