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[PMID]: 24505589
[Au] Autor:Turner MJ; Adams BB
[Ti] Title:Herpes labialis-induced lip leukoderma.
[So] Source:Cutis;93(1):E1-2, 2014 Jan.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Herpes Labialis/complications
Hypopigmentation/virology
Lip Diseases/virology
[Mh] MeSH terms secundary: Humans
Hypopigmentation/diagnosis
Hypopigmentation/pathology
Lip/pathology
Lip/virology
Lip Diseases/diagnosis
Lip Diseases/pathology
Middle Aged
[Pt] Publication type:CASE REPORTS; LETTER
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140207
[St] Status:MEDLINE

  2 / 5524 MEDLINE  
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[PMID]: 24337728
[Au] Autor:Jaiman S; Gundabattula SR; Pochiraju M; Sangireddy JR
[Ad] Address:Department of Anatomic and Perinatal Pathology and Cytology, Fernandez Hospital, Hyderabad, Andhra Pradesh, India.
[Ti] Title:Polypoid endometriosis of the cervix: a case report and review of the literature.
[So] Source:Arch Gynecol Obstet;289(4):915-20, 2014 Apr.
[Is] ISSN:1432-0711
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Giant and multilobular endocervical polyps are rare and need to be differentiated from cervical neoplastic lesions. CASE REPORT: The authors report a 29-year-old sexually inactive woman presenting with a prolapsed giant endocervical polyp, associated with malodorous discharge and menorrhagia. The wide-based polyp originated in part from the posterior lip of the exocervix and in part from the endocervix. This trilobular pedunculated mass (90 × 50 × 35 mm) had small cysts on the surface and focal areas of haemorrhage. Microscopic examination revealed areas with classic endocervical mucosal polyp histology intimately mixed with expanses of endometrial stroma and occasional endometrial glands. Immunohistochemically the endometrial stroma showed strong CD10 positivity, glands were oestrogen and progesterone receptor positive and Ki-67 proliferation index was low. CONCLUSION: Polypoid endometriosis of the cervix is a distinct form of endometriosis that may be mistaken for a neoplasm. Five earlier reports of this entity have not described a prolapsed polyp assuming gigantic proportions. We conclude that this condition be considered in the differential diagnosis of polypoid lesions of the cervix.
[Mh] MeSH terms primary: Endometriosis/pathology
Polyps/pathology
Uterine Cervical Diseases/pathology
[Mh] MeSH terms secundary: Adult
Endometriosis/surgery
Female
Humans
Menorrhagia/etiology
Menorrhagia/surgery
Prolapse
Uterine Cervical Diseases/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140311
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-013-3112-5

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[PMID]: 24698626
[Au] Autor:Kadaba P; Arepalli S; Shields JA; Shields CL
[Ad] Address:Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania....
[Ti] Title:Combined hamartoma of the retina and retinal pigment epithelium in branchio-otic syndrome.
[So] Source:J AAPOS;18(2):201-3, 2014 Apr.
[Is] ISSN:1528-3933
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 15-month-old boy with established branchio-otic syndrome was evaluated for decreased red reflex in the left eye. Fundus examination of left eye revealed a gray epiretinal membrane with retinal traction and ill-defined macular thickening, found on ultrasonography as a dense flat region 1.7 mm in thickness. Enhanced depth imaging optical coherence tomography revealed an epiretinal membrane with macular thickening, retinal folding, and full-thickness retinal disorganization, consistent with combined hamartoma of the retina and retinal pigment epithelium. Over 5 years of follow-up, the branchio-otic syndrome was unchanged and the combined hamartoma remained stable.
[Mh] MeSH terms primary: Branchio-Oto-Renal Syndrome/complications
Hamartoma/etiology
Retinal Diseases/etiology
Retinal Pigment Epithelium/pathology
[Mh] MeSH terms secundary: Branchio-Oto-Renal Syndrome/diagnosis
Epiretinal Membrane/diagnosis
Fluorescein Angiography
Hamartoma/diagnosis
Hearing Loss/diagnosis
Humans
Infant
Male
Retinal Diseases/diagnosis
Tomography, Optical Coherence
Visual Acuity/physiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140404
[St] Status:MEDLINE

  4 / 5524 MEDLINE  
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[PMID]: 24553598
[Au] Autor:O'brien SF; Xi G; Fan W; Yi QL; Osmond L; Delage G; Goldman M
[Ad] Address:Canadian Blood Services, Ottawa, Ontario, Canada Departments of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada....
[Ti] Title:Are donors in Canada compliant with deferral for tattoos and piercing?
[So] Source:Blood Transfus;12(1):141-2, 2014 Jan.
[Is] ISSN:1723-2007
[Cp] Country of publication:Italy
[La] Language:eng
[Mh] MeSH terms primary: Blood Donors
Body Piercing/adverse effects
Cooperative Behavior
Tattooing/adverse effects
[Mh] MeSH terms secundary: Canada
Female
Humans
Male
Virus Diseases/blood
Virus Diseases/transmission
[Pt] Publication type:LETTER
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140220
[St] Status:MEDLINE
[do] DOI:10.2450/2014.0233-13

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[PMID]: 24165655
[Au] Autor:Ueda K; Otsuki Y; Okada M; Nuri T; Yamada A
[Ad] Address:Osaka Medical College Takatsuki, Osaka, Japan.
[Ti] Title:Deepithelialized oral vestibular flap (boot flap) to correct whistling lip deformity.
[So] Source:Plast Reconstr Surg;132(5):881e-883e, 2013 Nov.
[Is] ISSN:1529-4242
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Lip Diseases/surgery
Lip/surgery
Mouth Mucosa/surgery
Reconstructive Surgical Procedures/methods
Surgical Flaps
[Mh] MeSH terms secundary: Adolescent
Child
Cleft Lip/surgery
Female
Humans
Lip Diseases/etiology
Male
Reconstructive Surgical Procedures/adverse effects
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1401
[Cu] Class update date: 141013
[Lr] Last revision date:141013
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1097/01.prs.0000435514.98978.f8

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[PMID]: 24165606
[Au] Autor:Cecini M; Pavese C; Comelli M; Carlisi E; Sala V; Bejor M; Dalla Toffola E
[Ad] Address:Pavia, Italy From the Department of Physical Medicine and Rehabilitation and the Public Health Department, University of Pavia; and the Rehabilitation Unit, Fondazione IRCCS Policlinico San Matteo; and Rehabilitation Unit, Fondazione Don Carlo Gnocchi ONLUS, "Santa Maria alle Fonti" Medical Center.
[Ti] Title:Quantitative measurement of evolution of postparetic ocular synkinesis treated with botulinum toxin type A.
[So] Source:Plast Reconstr Surg;132(5):1255-64, 2013 Nov.
[Is] ISSN:1529-4242
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The Sunnybrook Facial Grading System is considered one of the best scales available to grade facial motility and postparetic synkinesis. To measure facial landmarks and movement excursion, a new software, the Facial Assessment by Computer Evaluation, has been proposed. The aim of this study was to quantify eye synkinesis improvement after botulinum toxin type A injections using the new software and to compare this method with the Sunnybrook grading system. METHODS: The study included 40 injection sessions on 29 Caucasian outpatients with facial synkinesis. Before and 2 weeks after the injection, patients were evaluated using the Italian version of the Sunnybrook system. Eyelid fissure size at rest, during lip puckering, and while smiling was measured with the new software. RESULTS: After botulinum infiltration, the Sunnybrook grading system showed a global facial improvement with reduction of synkinesis and increase of static and dynamic symmetry. The Facial Assessment software detected an increase of ocular fissure measure at rest, during lip puckering, and especially during smiling, and the improvement was positively correlated with initial asymmetry. A single point of the Sunnybrook system synkinesis score corresponded to a mean difference of 0.77 mm during smiling and 1.0 mm during lip puckering. CONCLUSIONS: The Facial Assessment by Computer Evaluation measure allowed the authors to quantify the improvement of eye synkinesis after botulinum toxin type A injection. The Sunnybrook Facial Grading System provided an immediate instrument with which to monitor treatment in routine clinical practice, whereas the Facial Assessment system gave a more accurate quantitative assessment. CLINICAL QUESTION/LEVEL OF EVIDENCE: Diagnostic, II.
[Mh] MeSH terms primary: Botulinum Toxins, Type A/administration & dosage
Facial Muscles/drug effects
Facial Nerve Diseases/drug therapy
Neuromuscular Agents/administration & dosage
Synkinesis/drug therapy
[Mh] MeSH terms secundary: Adult
Aged
Eye
Facial Asymmetry/drug therapy
Facial Paralysis/complications
Facial Paralysis/drug therapy
Female
Humans
Injections
Male
Middle Aged
Synkinesis/etiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Neuromuscular Agents); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Entry month:1401
[Cu] Class update date: 141013
[Lr] Last revision date:141013
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0b013e3182a48d16

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[PMID]: 23924651
[Au] Autor:Okada HC; Alleyne B; Varghai K; Kinder K; Guyuron B
[Ad] Address:Cleveland, Ohio From the Departments of Plastic Surgery and Otolaryngology-Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland.
[Ti] Title:Facial changes caused by smoking: a comparison between smoking and nonsmoking identical twins.
[So] Source:Plast Reconstr Surg;132(5):1085-92, 2013 Nov.
[Is] ISSN:1529-4242
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The purpose of this study was to identify the specific components of facial aging secondary to smoking, by comparing standardized photographs of identical twins with different smoking histories. METHODS: During the Twins Days Festival in Twinsburg, Ohio, from 2007 to 2010, 79 pairs of twins were identified, in which only one twin smokes or where one twin smoked at least 5 years longer than his or her counterpart. Questionnaires were obtained and standardized photographs were taken by professional photographers. A panel of three blinded judges analyzed the twins' facial features and graded wrinkles using the validated Lemperle Assessment Scale, and ranked age-related facial features on a four-point scale. RESULTS: Smoking twins compared with their nonsmoking counterparts had worse scores for upper eyelid skin redundancy, lower lid bags, malar bags, nasolabial folds, upper lip wrinkles, lower lip vermillion wrinkles, and jowls. Lower lid hyperpigmentation in the smoking group fell just short of statistical significance. Transverse forehead wrinkles, glabellar wrinkles, crow's feet, and lower lip lines accentuated by puckering did not have a statistically significant differences in scores. Among twins with greater than 5 years' difference in smoking duration, twins who had smoked longer had worse scores for lower lid bags, malar bags, and lower lip vermillion wrinkles. CONCLUSIONS: This study details the specifics of facial aging brought on by smoking, which primarily affects the middle and lower thirds of the face. It also demonstrates that a 5-year difference in smoking history can cause noticeable differences in facial aging in twins. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, II.
[Mh] MeSH terms primary: Face/pathology
Skin Aging/pathology
Smoking/adverse effects
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Diseases in Twins
Female
Humans
Male
Middle Aged
Photography
Twins, Monozygotic
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1401
[Cu] Class update date: 141013
[Lr] Last revision date:141013
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0b013e3182a4c20a

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[PMID]: 24022197
[Au] Autor:Hunter N; Kuznetsova IS; Labutina EV; Harrison JD
[Ad] Address:Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Oxfordshire OX11 0RQ, UK.
[Ti] Title:Solid cancer incidence other than lung, liver and bone in Mayak workers: 1948-2004.
[So] Source:Br J Cancer;109(7):1989-96, 2013 Oct 1.
[Is] ISSN:1532-1827
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cancer incidence in the Mayak Production Association (PA) cohort was analysed to investigate for the first time whether external gamma-ray and internal plutonium exposure are associated with raised incidence of solid cancers other than lung, liver and bone (other solid cancers). METHODS: The cohort includes 22,366 workers of both sexes who were first employed between 1948 and 1982. A total of 1447 cases of other solid cancers were registered in the follow-up period until 2004. The Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to plutonium and external gamma-ray. RESULTS: A weak association was found between cumulative exposure to external gamma-ray and the incidence of other solid cancers (ERR/Gy=0.07; 95% confidence intervals (CIs): 0.01-0.15), but this association lost its significance after adjusting for internal plutonium exposure. There was no indication of any association with plutonium exposure for other solid cancers. Among 16 individual cancer sites, there was a statistically significant association with external exposure for lip cancer (ERR/Gy=1.74; 95% CI: 0.37; 6.71) and with plutonium exposure for pancreatic cancer (ERR/Gy=1.58; 95% CI; 0.17; 4.77). CONCLUSION: This study of Mayak workers does not provide evidence of an increased risk of other solid cancers. The observed increase in the risk of cancer of the lip and pancreas should be treated with caution because of the limited amount of relevant data and because the observations may be simply due to chance.
[Mh] MeSH terms primary: Gamma Rays/adverse effects
Neoplasms, Radiation-Induced/epidemiology
Occupational Diseases/epidemiology
Occupational Exposure
Plutonium/adverse effects
[Mh] MeSH terms secundary: Cohort Studies
Female
Humans
Incidence
Male
Nuclear Reactors
Nuclear Weapons
Questionnaires
Russia/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Name of substance:53023GN24M (Plutonium)
[Em] Entry month:1312
[Cu] Class update date: 141009
[Lr] Last revision date:141009
[Js] Journal subset:IM
[Da] Date of entry for processing:131002
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2013.543

  9 / 5524 MEDLINE  
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[PMID]: 24102903
[Au] Autor:Marquezin MC; Gavião MB; Alonso MB; Ramirez-Sotelo LR; Haiter-Neto F; Castelo PM
[Ad] Address:Department of Pediatric Dentistry, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
[Ti] Title:Relationship between orofacial function, dentofacial morphology, and bite force in young subjects.
[So] Source:Oral Dis;20(6):567-73, 2014 Sep.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim was to evaluate the relationship between orofacial function, dentofacial morphology, and bite force in young subjects. SUBJECTS AND METHODS: Three hundred and sixteen subjects were divided according to dentition stage (early, intermediate, and late mixed and permanent dentition). Orofacial function was screened using the Nordic Orofacial Test-Screening (NOT-S). Orthodontic treatment need, bite force, lateral and frontal craniofacial dimensions and presence of sleep bruxism were also assessed. The results were submitted to descriptive statistics, normality and correlation tests, analysis of variance, and multiple linear regression to test the relationship between NOT-S scores and the studied independent variables. RESULTS: The variance of NOT-S scores between groups was not significant. The evaluation of the variables that significantly contributed to NOT-S scores variation showed that age and presence of bruxism related to higher NOT-S total scores, while the increase in overbite measurement and presence of closed lip posture related to lower scores. Bite force did not show a significant relationship with scores of orofacial dysfunction. No significant correlations between craniofacial dimensions and NOT-S scores were observed. CONCLUSION: Age and sleep bruxism were related to higher NOT-S scores, while the increase in overbite measurement and closed lip posture contributed to lower scores of orofacial dysfunction.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1408
[Js] Journal subset:D
[St] Status:In-Process
[do] DOI:10.1111/odi.12174

  10 / 5524 MEDLINE  
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[PMID]: 24489909
[Au] Autor:Musharraf A; Kruspe D; Tomasch J; Besenbeck B; Englert C; Landgraf K
[Ad] Address:Leibniz Institute for Age Research - Fritz Lipmann Institute e. V. (FLI), Jena, Germany....
[Ti] Title:BOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein.
[So] Source:PLoS One;9(1):e87407, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mutations in the human EYA1 gene have been associated with several human diseases including branchio-oto (BO) and branchio-oto-renal (BOR) syndrome, as well as congenital cataracts and ocular anterior segment anomalies. BOR patients suffer from severe malformations of the ears, branchial arches and kidneys. The phenotype of Eya1-heterozygous mice resembles the symptoms of human patients suffering from BOR syndrome. The Eya1 gene encodes a multifunctional protein that acts as a protein tyrosine phosphatase and a transcriptional coactivator. It has been shown that Eya1 interacts with Six transcription factors, which are also required for nuclear translocation of the Eya1 protein. We investigated the effects of seven disease-causing Eya1 missense mutations on Eya1 protein function, in particular cellular localization, ability to interact with Six proteins, and protein stability. We show here that the BOR-associated Eya1 missense mutations S454P, L472R, and L550P lead to enhanced proteasomal degradation of the Eya1 protein in mammalian cells. Moreover, Six proteins lead to a significant stabilization of Eya1, which is caused by Six-mediated protection from proteasomal degradation. In case of the mutant L550P, loss of interaction with Six proteins leads to rapid protein degradation. Our observations suggest that protein destabilization constitutes a novel disease causing mechanism for Eya1.
[Mh] MeSH terms primary: Branchio-Oto-Renal Syndrome/genetics
Intracellular Signaling Peptides and Proteins/genetics
Nuclear Proteins/genetics
Proteasome Endopeptidase Complex/metabolism
Protein Tyrosine Phosphatases/genetics
[Mh] MeSH terms secundary: Animals
COS Cells
Cell Line, Tumor
Cell Nucleus/metabolism
Cercopithecus aethiops
Homeodomain Proteins/metabolism
Humans
Intracellular Signaling Peptides and Proteins/metabolism
Mice
Mutation, Missense
Nuclear Proteins/metabolism
Protein Binding
Protein Stability
Protein Transport
Protein Tyrosine Phosphatases/metabolism
Proteolysis
Ubiquitination
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Homeodomain Proteins); 0 (Intracellular Signaling Peptides and Proteins); 0 (Nuclear Proteins); EC 3.1.3.48 (Eya1 protein, mouse); EC 3.1.3.48 (Protein Tyrosine Phosphatases); EC 3.4.25.1 (Proteasome Endopeptidase Complex)
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0087407


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