Database : MEDLINE
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[PMID]: 26964448
[Au] Autor:Taute RB; Wylie J; Carter L
[Ti] Title:An Unusual Extranodal Presentation of Mycobacterium Tuberculosis in the Upper Lip.
[So] Source:Dent Update;42(5):473-5, 2015 Jun.
[Is] ISSN:0305-5000
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide, with a peak incidence in South-East Asia and Sub- Saharan Africa. A significant number of patients in the UK are affected. Extra-pulmonary TB presentation varies, and includes head and neck manifestations that can present on routine examination in the dental practice setting. We report an unusual case of extra-nodal TB in the upper lip, and provide some guidance to general dental practitioners on the presenting features of such lesions, and what to refer for further investigation where TB is included in the differential diagnosis. CPD/CLINICAL RELEVANCE: This case report highlights important factors in TB diagnosis, with particular emphasis on presenting features relevant to general dental practitioners, and informs on the accepted and current treatment regimen.
[Mh] MeSH terms primary: Lip Diseases/microbiology
Tuberculosis, Oral/diagnosis
[Mh] MeSH terms secundary: Abscess/microbiology
Antitubercular Agents/therapeutic use
Diagnosis, Differential
Female
Humans
Mycobacterium tuberculosis/isolation & purification
Suppuration
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antitubercular Agents)
[Em] Entry month:1604
[Js] Journal subset:D
[Da] Date of entry for processing:160311
[St] Status:MEDLINE

  2 / 5355 MEDLINE  
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[PMID]: 26666112
[Au] Autor:Brailo V; Boras VV; Seiwert S; Tomasic V; Bakale I; Juras DV; Hadzavdic SL
[Ti] Title:OROFACIAL GRANULOMATOSIS: CASE REPORT.
[So] Source:Acta Clin Croat;54(3):378-80, 2015 Sep.
[Is] ISSN:0353-9466
[Cp] Country of publication:Croatia
[La] Language:eng
[Ab] Abstract:An 18-year-old girl was referred to the Department of Oral Medicine with upper lip swelling. She was in good general health and laboratory tests were within the normal range. Histopathologic diagnosis did not reveal the presence of granulomas. This is consistent with the finding that 30% of patients with orofacial granulomatosis do not have granulomas on their biopsies. The patient was treated with intralesional steroids once a week for three weeks. The lesion subsided, but not completely, and recurred partially after ketchup intake. This case report highlights the fact that in every patient with non-odontogenic facial or oral swelling, systemic diseases such as sarcoidosis, Crohn's disease, tuberculosis, etc. must be excluded. Furthermore, it is not unusual that in patients with orofacial granulomatosis, noncaseating granulomas are absent in the histopathologic finding.
[Mh] MeSH terms primary: Granulomatosis, Orofacial/diagnosis
[Mh] MeSH terms secundary: Adolescent
Adrenal Cortex Hormones/therapeutic use
Female
Granulomatosis, Orofacial/drug therapy
Humans
Injections, Intralesional
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Adrenal Cortex Hormones)
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:151215
[St] Status:MEDLINE

  3 / 5355 MEDLINE  
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[PMID]: 26559461
[Au] Autor:Itoh N
[Ad] Address:Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo, Kyoto 606-8507, Japan. Electronic address: nobuyuki.itoh.56c@st.kyoto-u.ac.jp.
[Ti] Title:FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease.
[So] Source:Cytokine Growth Factor Rev;28:63-9, 2016 Apr.
[Is] ISSN:1879-0305
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The FGF family comprises 22 members with diverse functions in development and health. FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor. FGF10and FGFR2b are preferentially expressed in the mesenchyme and epithelium, respectively. FGF10 is a mesenchymal signaling molecule in the epithelium. FGF10 knockout mice die shortly after birth due to the complete absence of lungs as well as fore- and hindlimbs. FGF10 is also essential for the development of multiple organs. The phenotypes of Fgf10 knockout mice are very similar to those of FGFR2b knockout mice, indicating that FGF10 acts as a ligand that is specific to FGFR2b in mouse multi-organ development. FGF10 also plays roles in epithelial-mesenchymal transition, the repair of tissue injury, and embryonic stem cell differentiation. In humans, FGF10 loss-of-function mutations result in inherited diseases including aplasia of lacrimal and salivary gland, lacrimo-auriculo-dento-digital syndrome, and chronic obstructive pulmonary disease. FGF10 is also involved in the oncogenicity of pancreatic and breast cancers. Single nucleotide polymorphisms in FGF10 are also potential risk factors for limb deficiencies, cleft lip and palate, and extreme myopia. These findings indicate that FGF10 is a crucial paracrine signal from the mesenchyme to epithelium for development, health, and disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 5355 MEDLINE  
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[PMID]: 24603223
[Au] Autor:Bryan S; Lim J; Mackenzie N
[Ti] Title:Piercings: Grossly swollen tongue.
[So] Source:Br Dent J;216(5):210-1, 2014 Mar.
[Is] ISSN:1476-5373
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Body Piercing/adverse effects
Tongue Diseases/etiology
[Mh] MeSH terms secundary: Emergency Service, Hospital
Humans
Male
Middle Aged
Tongue/injuries
[Pt] Publication type:CASE REPORTS; LETTER
[Em] Entry month:1604
[Js] Journal subset:D; IM
[Da] Date of entry for processing:140307
[St] Status:MEDLINE
[do] DOI:10.1038/sj.bdj.2014.152

  5 / 5355 MEDLINE  
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[PMID]: 27069897
[Au] Autor:Gandhi R; Bhowate R; Nayyar AS; Gandhi S; Dongarwar G
[Ad] Address:Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India....
[Ti] Title:Color Doppler-ultrasonography in oral squamous cell carcinoma: Making ultrasonography more meaningful.
[So] Source:Adv Biomed Res;5:29, 2016.
[Is] ISSN:2277-9175
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Although color Doppler ultrasonography (CD-USG) is useful in the diagnosis of various diseases of the head and neck, flow signals in the malignant oral tumors are less studied. This study aimed to study the usefulness of CD-USG in mapping OSCC of buccal mucosa, tongue, and lip. MATERIALS AND METHODS: This was a case-control study, conducted among 60 subjects aged 20-70 years. Group A consisted of 30 cases of OSCC of buccal mucosa, tongue, and lip, whereas Group B consisted of 30 controls. CD-USG investigation of each mass was carried out. The spectral waveform (time velocity Doppler spectrum) of flow signal was analyzed for the pulsatility index (PI), resistivity index (RI), peak systolic velocity (PSV) (m/s), and end diastolic velocity (EDV) (m/s). All patients had real-time, gray-scale sonography and CD-USG with spectral wave analysis. RESULTS: In this study, the mean value for RI in patients with malignancy was 0.40 + 0.14, whereas for healthy subjects, it was 0.83 + 0.07. The mean value for PI in patients with malignancy was 0.86 + 0.20, whereas for healthy subjects, it was 2.61 + 0.77. In the present study, the mean PSV in malignant masses was 31.72 + 13.48, whereas for healthy subjects, it was 43.87 + 20.95, and the EDV in malignant masses was 10.33 + 5.21, whereas for healthy subjects, it was 7.07 + 3.44. CONCLUSIONS: The said Doppler indices were shown to be sensitive as well as specific for the diagnosis of malignant oral tumors. Although CD-USG cannot replace histopathological procedures, it plays a definite role as an adjunct to the clinical evaluation of OSCC cases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Cu] Class update date: 160415
[Lr] Last revision date:160415
[Da] Date of entry for processing:160412
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2277-9175.178068

  6 / 5355 MEDLINE  
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[PMID]: 23613323
[Au] Autor:Winberg J; Lagerstedt Robinson K; Naess K; Lesko N; Wibom R; Liedén A; Anderlid BM; Graff C; Nordenskjöld A; Nordgren A; Gustavsson P
[Ad] Address:Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. johanna.winberg@ki.se
[Ti] Title:Partial tetrasomy 14 associated with multiple malformations.
[So] Source:Am J Med Genet A;161A(6):1284-90, 2013 Jun.
[Is] ISSN:1552-4833
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report on an 8-year-old female patient with multiple malformations including bilateral cleft lip and palate, coloboma, and craniosynostosis. She presented with severe intellectual disability, seizures, and gastrointestinal dysfunction. Mitochondrial investigations in a muscle biopsy revealed reduced activity in complex I of the mitochondrial respiratory chain. Chromosome analysis and fluorescent in situ hybridization (FISH) studies showed an isodicentric marker chromosome 14 that was identified in all cells analyzed in peripheral blood lymphocytes and cultured fibroblasts. Parental chromosome studies were normal. To further characterize the marker chromosome and determine its origin, we performed array-based comparative genomic hybridization (CGH) and polymorphic marker analysis with quantitative fluorescent PCR (QF-PCR). The combined results from cytogenetic and array-CGH analyses showed tetrasomy 14p13q13.1 and results from the QF-PCR point to formation of the marker chromosome in the maternal meiosis. Isodicentric chromosomes involving partial 14q have previously been reported in four cases; however, this is the first patient with tetrasomy 14p13q13.1 in non-mosaic form surviving beyond infancy.
[Mh] MeSH terms primary: Abnormalities, Multiple/genetics
Chromosomes, Human, Pair 14/genetics
Tetrasomy/genetics
[Mh] MeSH terms secundary: Child
Cleft Lip/genetics
Coloboma/genetics
Comparative Genomic Hybridization
Craniosynostoses/genetics
Electron Transport Complex I/deficiency
Electron Transport Complex I/metabolism
Female
Gastrointestinal Diseases/genetics
Humans
In Situ Hybridization, Fluorescence
Intellectual Disability/genetics
Karyotyping
Microsatellite Repeats/genetics
Mitochondrial Diseases/metabolism
Models, Genetic
Muscle, Skeletal/metabolism
Seizures/genetics
Sweden
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:EC 1.6.5.3 (Electron Transport Complex I)
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:130524
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.35887

  7 / 5355 MEDLINE  
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[PMID]: 25973908
[Au] Autor:Fujii M; Tachibana K; Takeuchi M; Nishio J; Kinouchi K
[Ad] Address:Department of Anesthesia and Intensive Care, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan....
[Ti] Title:Perioperative management of 19 infants undergoing glossopexy (tongue-lip adhesion) procedure: a retrospective study.
[So] Source:Paediatr Anaesth;25(8):829-33, 2015 Aug.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Glossopexy (tongue-lip adhesion) is a procedure in which the tongue is anchored to the lower lip and mandible to relieve the upper airway obstruction mainly in infants with Pierre Robin sequence. Infants suffering from severe upper airway obstruction and feeding difficulties due to glossoptosis are the candidates for this procedure and are predicted to demonstrate difficult airway and difficult intubation. METHODS: We retrospectively examined the perioperative management of 19 infants undergoing glossopexy procedure at our institution from 1992 to 2010. RESULTS: Out of 19 patients, Pierre Robin sequence was diagnosed in 17, Treacher Collins syndrome in 1, and Stickler syndrome in 1. In all of them, inhalation anesthesia was induced with a nasopharyngeal tube in place. Nine patients underwent fiberoptic intubation. After surgery, 12 patients were extubated in the operating room and 11 of them required a nasopharyngeal tube to keep the airway open. Seven patients left the operating room with the trachea intubated. Two patients received tracheostomy at the age of 2 months. Seventeen patients underwent release of tongue-lip adhesion coincidentally with the palate repair at 7-14 months of age. For this surgery, no one required fiberoptic intubation. CONCLUSIONS: The airway of these patients should be managed carefully not only before but also after the operation. A nasopharyngeal tube was effective in maintaining the upper airway patency during anesthesia induction and before and after operation.
[Mh] MeSH terms primary: Airway Management/methods
Craniofacial Abnormalities/surgery
Lip/surgery
Perioperative Care/methods
Tongue/surgery
[Mh] MeSH terms secundary: Arthritis/surgery
Connective Tissue Diseases/surgery
Female
Fiber Optic Technology
Hearing Loss, Sensorineural/surgery
Humans
Infant
Infant, Newborn
Intubation, Intratracheal/methods
Male
Mandibulofacial Dysostosis/surgery
Pierre Robin Syndrome/surgery
Retinal Detachment/surgery
Retrospective Studies
Tracheostomy
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:150707
[St] Status:MEDLINE
[do] DOI:10.1111/pan.12675

  8 / 5355 MEDLINE  
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[PMID]: 26728781
[Au] Autor:Yin X; Zhang H; Zhu Z; Wang H; Du Y; Li S; Zhang Z; Fan W; Pan Y
[Ad] Address:Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China....
[Ti] Title:FOXE1 polymorphisms and non-syndromic orofacial cleft susceptibility in a Chinese Han population.
[So] Source:Oral Dis;22(4):274-9, 2016 May.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:OBJECTIVE: FOXE1 plays an important role in craniofacial development. The aim of this study was to investigate associations between genetic variants of FOXE1 and risk of non-syndromic orofacial clefts in a Chinese population. MATERIALS AND METHODS: Three potentially functional SNPs of FOXE1 (rs3758250 and rs907577 in the 5' upstream and rs7043516 in the 3'-UTR) were selected and their associations with non-syndromic orofacial cleft susceptibility were investigated in a case-control study from a Chinese population (602 cases and 605 controls). Genotyping was performed with double ligation and multiplex fluorescence PCR. Associations between the SNPs and risk of non-syndromic orofacial clefts and its subgroups were estimated from unconditional logistic regression analysis. Luciferase reporter assay was conducted to assess SNP function. RESULTS: Overall, we did not find any of the individual SNP or haplotype was associated with NSOC susceptibility. Nevertheless, in stratified analysis, we found rs7043516, locating in the 3'-UTR of FOXE1, was associated with risk of cleft lip only. Further in vitro luciferase assay indicated that this SNP could contribute to differential binding ability with miRNA. CONCLUSIONS: Taken together, this study showed that rs7043516 may be considered as a potentially susceptible marker of cleft lip only among Chinese Han populations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:D
[St] Status:In-Data-Review
[do] DOI:10.1111/odi.12435

  9 / 5355 MEDLINE  
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[PMID]: 26044608
[Au] Autor:Al-Hiyali A; Ayoub A; Ju X; Almuzian M; Al-Anezi T
[Ad] Address:Master's Student of Oral and Maxillofacial Surgery, College of Medicine, College of Medical, Veterinary and Life Sciences, Glasgow University Dental Hospital and School, Glasgow, UK....
[Ti] Title:The Impact of Orthognathic Surgery on Facial Expressions.
[So] Source:J Oral Maxillofac Surg;73(12):2380-90, 2015 Dec.
[Is] ISSN:1531-5053
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to evaluate the impact of orthognathic surgical correction of facial asymmetry and maxillary hypoplasia on the magnitude and pattern of facial expressions. PATIENTS AND METHODS: This study was carried out on 2 cohorts of patients: in group 1, 10 patients had surgical correction of facial asymmetry; in group 2, 13 patients had Le Fort I osteotomy to correct maxillary hypoplasia. The patients were asked to perform 3 facial expressions (maximal smile, lip purse, and cheek puff) that were recorded using the Di4D image-capture system before and after surgery. The capture of each expression generated 180 3-dimensional (3D) facial images. Twenty-seven facial soft tissue landmarks were digitized on the first frame of the 3D image of each expression and a mathematical generic mesh was applied on the 3D model to clone each patient's face. The cloned mesh was superimposed automatically on each sequence of the 3D images to evaluate the pattern of facial expressions. The digitization of facial landmarks was satisfactorily accurate and reproducible. RESULTS: In group 1, the asymmetry of facial expressions was significantly decreased after surgical correction (P = .0458). In group 2, Le Fort I osteotomy decreased the magnitude of facial expressions (P = .0267). CONCLUSION: This study confirmed that orthognathic surgery affects the dynamics of facial expressions; this should be considered when planning the surgery and informing patients about the surgical correction of dentofacial deformities.
[Mh] MeSH terms primary: Facial Expression
Orthognathic Surgical Procedures/adverse effects
[Mh] MeSH terms secundary: Adolescent
Adult
Facial Asymmetry/surgery
Female
Humans
Image Processing, Computer-Assisted/methods
Imaging, Three-Dimensional/methods
Male
Maxillary Diseases/surgery
Middle Aged
Orthognathic Surgical Procedures/methods
Osteotomy, Le Fort/adverse effects
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:AIM; D; IM
[Da] Date of entry for processing:151126
[St] Status:MEDLINE

  10 / 5355 MEDLINE  
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[PMID]: 25974875
[Au] Autor:Ilea A; Cristea A; Dudescu CM; Hurubeanu L; Vâjâean C; Albu S; Câmpian RS
[Ad] Address:Department of Oral Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania....
[Ti] Title:Lip Forces and Chewing Efficiency in Children with Peripheral Facial Paralysis.
[So] Source:Neuropediatrics;46(4):242-7, 2015 Aug.
[Is] ISSN:1439-1899
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Peripheral facial paralysis is accompanied by facial motor disorders and also, by oral dysfunctions. The aim of this study was to evaluate the lip forces and chewing efficiency in a group of children with peripheral facial paralysis. The degree of peripheral facial paralysis in the study group (n 11) was assessed using the House-Brackmann scale. The control group consisted of 21 children without facial nerve impairment. To assess lip forces, acrylic vestibular plates of three sizes were used: large (LVP), medium (MVP) and small (SVP). The lip force was recorded with a force transducer coupled with the data acquisition system. Masticatory efficiency was evaluated by the ability to mix two differently colored chewing gums. The images were processed with Adobe Photoshop CS3 (Delaware Corporation, San Jose, California, United States) and the number of pixels was quantified with the Image J software (DHHS/NIH/NIMH/RSB, Maryland, United States). For statistical analysis, the following statistical analysis were used: Pearson or Spearman correlation coefficient, multiple linear regression analysis, multiple logistic regression analysis, and optimal cutoff values for muscular dysfunction. There were statistically significant differences between lip forces in the following three groups: p=0.01 (LVP), p=0.01 (MVP), and p=0.008 (SVP). The cutoff values of lip forces in the study group were as follows: 7.08 N (LVP), 4.89 N (MVP), and 4.24 N (SVP). There were no statistically significant differences between the masticatory efficiency in the two groups (p=0.25). Lip forces were dependent on the degree of peripheral facial paralysis and age, but not on gender. In peripheral facial paralysis in children, a significant decrease of lip forces, but not masticatory efficiency, occurs.
[Mh] MeSH terms primary: Facial Nerve Diseases/complications
Facial Paralysis/physiopathology
Lip/physiopathology
Mastication
[Mh] MeSH terms secundary: Adolescent
Child
Facial Paralysis/complications
Female
Humans
Lip/innervation
Male
Severity of Illness Index
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:150720
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1550146


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