Database : MEDLINE
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[PMID]: 23011170
[Au] Autor:Bay Bjørn AM; Ehrenstein V; Hundborg HH; Nohr EA; Sørensen HT; Nørgaard M
[Ad] Address:1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; and 2Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark.
[Ti] Title:Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring.
[So] Source:Am J Ther;21(2):73-80, 2014 Mar-Apr.
[Is] ISSN:1536-3686
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Corticosteroids are commonly used to treat inflammatory diseases. There is conflicting evidence regarding the association of corticosteroid use in pregnancy and congenital malformations in offspring. We conducted a prevalence study of 83,043 primiparous women who gave birth to a live-born singleton in northern Denmark, in 1999-2009. Through medical registries, we identified prescriptions for corticosteroids, congenital malformations, and covariates. Furthermore, we summarized the literature on this topic. Overall, 1449 women (1.7%) used inhaled or oral corticosteroids from 30 days before conception throughout the first trimester. Oral cleft in the offspring was recorded for 1 of the users (0.08%) and 145 of the nonusers (0.2%), prevalence odds ratio (OR) 0.47 [95% confidence interval (CI), 0.07-3.34]. The prevalence OR for congenital malformations overall was 1.02 (95% CI, 0.79-1.32). According to published studies, the use of corticosteroids in early pregnancy was associated with congenital malformations overall with relative estimates ranging from 0.8 (95% CI, 0.4-1.7) to 2.1 (95% CI, 0.5-9.6). For oral clefts, the ORs ranged from 0.6 (95% CI, 0.2-1.7) to 5.2 (95% CI, 1.5-17.1). We found no evidence of an association between use of corticosteroids in early pregnancy and risk of congenital malformations in offspring.
[Mh] MeSH terms primary: Abnormalities, Drug-Induced/epidemiology
Cleft Lip/epidemiology
Cleft Palate/epidemiology
Glucocorticoids/administration & dosage
[Mh] MeSH terms secundary: Denmark/epidemiology
Female
Glucocorticoids/adverse effects
Humans
Infant, Newborn
Pregnancy
Pregnancy Trimester, First
Prevalence
Registries
Risk
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Glucocorticoids)
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:140306
[St] Status:MEDLINE
[do] DOI:10.1097/MJT.0b013e3182491e02

  2 / 5535 MEDLINE  
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[PMID]: 23011161
[Au] Autor:Toumeh A; Josh N; Narwal R; Assaly R
[Ad] Address:1Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH; and 2Department of Internal Medicine, St Vincent Mercy Medical Center, Toledo, OH.
[Ti] Title:Refractory thrombotic thrombocytopenic purpura associated with primary Sjogren syndrome treated with rituximab: a case report.
[So] Source:Am J Ther;21(2):e56-60, 2014 Mar-Apr.
[Is] ISSN:1536-3686
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Thrombotic thrombocytopenic purpura (TTP) is an uncommon, serious disease that involves multiple organs and is rapidly fatal if left untreated. TTP is associated with multisystem symptoms, such as thrombocytopenia, microangiopathic hemolytic anemia, renal impairment, central nervous system involvement, and fever. TTP is idiopathic in about 37% of the cases and can be associated with autoimmune diseases in 13% of the cases. Autoimmune disease-associated TTP can be refractory to plasma exchange and requires immunosuppressive therapy. We report a case of a previously healthy 55-year-old African American female who presented with shortness of breath, hemolytic anemia, renal impairment, and thrombocytopenia. The diagnosis of TTP was made, and plasmapheresis was initiated. However, recurrence happened 48 hours after plasmapheresis was stopped. Autoimmune workup for refractory TTP revealed positive antinuclear antibodies, Anti-SSA, and Anti-SSB. Lip biopsy revealed findings consistent with Sjogren syndrome. Treatment with Rituximab was started, and significant clinical and laboratory response was achieved. The patient remained asymptomatic thereafter. A high clinical suspicion of autoimmune diseases is important as TTP tends to be refractory to plasma exchange in these cases, and immunosuppressive therapy is a key.
[Mh] MeSH terms primary: Antibodies, Monoclonal, Murine-Derived/therapeutic use
Purpura, Thrombotic Thrombocytopenic/drug therapy
Sjogren´s Syndrome/complications
[Mh] MeSH terms secundary: Female
Humans
Immunologic Factors/therapeutic use
Middle Aged
Plasmapheresis/methods
Purpura, Thrombotic Thrombocytopenic/etiology
Recurrence
Sjogren's Syndrome/diagnosis
Sjogren's Syndrome/drug therapy
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Monoclonal, Murine-Derived); 0 (Immunologic Factors); 0 (rituximab)
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:140306
[St] Status:MEDLINE
[do] DOI:10.1097/MJT.0b013e3182459aa0

  3 / 5535 MEDLINE  
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[PMID]: 24124024
[Au] Autor:Kappen C
[Ti] Title:Modeling anterior development in mice: diet as modulator of risk for neural tube defects.
[So] Source:Am J Med Genet C Semin Med Genet;163C(4):333-56, 2013 Nov.
[Is] ISSN:1552-4876
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than 400 genes that contribute to proper neural tube closure have been identified in experimental animals, but only very few causative gene mutations have been identified in humans, supporting the notion that environmental influences are critical. The intrauterine environment is influenced by maternal nutrition, and hence, maternal diet can modulate the risk for cranial and neural tube defects. This article reviews recent progress toward a better understanding of nutrients during pregnancy, with particular focus on mouse models for defective neural tube closure. At least four major patterns of nutrient responses are apparent, suggesting that multiple pathways are involved in the response, and likely in the underlying pathogenesis of the defects. Folic acid has been the most widely studied nutrient, and the diverse responses of the mouse models to folic acid supplementation indicate that folic acid is not universally beneficial, but that the effect is dependent on genetic configuration. If this is the case for other nutrients as well, efforts to prevent neural tube defects with nutritional supplementation may need to become more specifically targeted than previously appreciated. Mouse models are indispensable for a better understanding of nutrient-gene interactions in normal pregnancies, as well as in those affected by metabolic diseases, such as diabetes and obesity.
[Mh] MeSH terms primary: Folic Acid/metabolism
Maternal Nutritional Physiological Phenomena
Morphogenesis
Neural Tube Defects/metabolism
[Mh] MeSH terms secundary: Anencephaly/genetics
Anencephaly/metabolism
Anencephaly/physiopathology
Animals
Cleft Lip/genetics
Cleft Lip/metabolism
Cleft Lip/physiopathology
Cleft Palate/complications
Cleft Palate/genetics
Cleft Palate/mortality
Diabetes, Gestational/genetics
Diabetes, Gestational/metabolism
Diabetes, Gestational/physiopathology
Dietary Supplements
Disease Models, Animal
Female
Gene-Environment Interaction
Humans
Mice
Neural Tube Defects/physiopathology
Pregnancy
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Name of substance:935E97BOY8 (Folic Acid)
[Em] Entry month:1405
[Cu] Class update date: 141104
[Lr] Last revision date:141104
[Js] Journal subset:IM
[Da] Date of entry for processing:131029
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.c.31380

  4 / 5535 MEDLINE  
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[PMID]: 24586218
[Au] Autor:Yamagata University Genomic Cohort Consortium (YUGCC)
[Ti] Title:Pleiotropic effect of common variants at ABO Glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme.
[So] Source:PLoS One;9(2):e55903, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:For forty-three clinical test values presumably associated to common complex human diseases, we carried out a genome-wide association study using 600K SNPs in a general Japanese population of 1,639 individuals (1,252 after quality control procedures) drawn from a regional cohort, followed by a replication study for statistically significant SNPs (p = 1.95 × 10(-9)-8.34 × 10(-39)) using an independent population of 1,671 from another cohort. In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of angiotensin converting enzyme (ACE) independent of the ACE1 gene in 17q23.2 with the ACE level. Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.
[Mh] MeSH terms primary: Genome-Wide Association Study/methods
Glycosyltransferases/blood
Peptidyl-Dipeptidase A/blood
[Mh] MeSH terms secundary: Genetic Predisposition to Disease/genetics
Humans
Polymorphism, Single Nucleotide/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:EC 2.4.- (Glycosyltransferases); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:140303
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0055903

  5 / 5535 MEDLINE  
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[PMID]: 24164694
[Au] Autor:Ahmad Z; Osunsade L
[Ad] Address:Auckland University Hospitals; Department of Otolaryngology - Head and Neck Surgery, Counties Manukau Health, Auckland, New Zealand.
[Ti] Title:Bilateral nasolabial cysts.
[So] Source:ANZ J Surg;84(3):189-90, 2014 Mar.
[Is] ISSN:1445-2197
[Cp] Country of publication:Australia
[La] Language:eng
[Mh] MeSH terms primary: Cysts
Lip Diseases
Nose Diseases
[Mh] MeSH terms secundary: Adolescent
Cysts/diagnosis
Female
Humans
Lip Diseases/diagnosis
Nose Diseases/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[Da] Date of entry for processing:140305
[St] Status:MEDLINE
[do] DOI:10.1111/ans.12239

  6 / 5535 MEDLINE  
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[PMID]: 25146364
[Au] Autor:Agarwal M; Apostolakis S; Lane DA; Lip GY
[Ad] Address:University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom....
[Ti] Title:The impact of heart failure and left ventricular dysfunction in predicting stroke, thromboembolism, and mortality in atrial fibrillation patients: a systematic review.
[So] Source:Clin Ther;36(9):1135-44, 2014 Sep 1.
[Is] ISSN:1879-114X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Atrial fibrillation (AF) is commonly associated with structural heart disease. Although heart failure (HF) has been proposed as a risk factor for stroke, the coexistence of the 2 diseases increases disproportionally the risk of thromboembolic events. Our objective was to conduct a systematic review to assess the effect of HF on the end points of stroke, systemic embolism (SE), or mortality in patients with AF. METHODS: A literature search was performed to identify studies that examined stroke/ SE in relation to AF and HF. Overall, 405 articles satisfied the preinclusion criteria. FINDINGS: In studies in which HF was based on a clinical diagnosis, HF independently increased stroke/SE in 5 of 13 studies, conferring 1.6- to 3.1-fold increase in risk. When HF was defined as impaired left ventricular (LV) function on echocardiography, the additive risk was evident in 4 of 6 studies, with 1.7- to 2.6-fold increase in the risk of stroke/SE. The data about HF with preserved ejection fraction were less robust, although a recent presentation with acute decompensated HF increased the risk of stroke/SE, irrespective of ejection fraction. IMPLICATIONS: LV systolic impairment as identified by echocardiography is an independent risk factor for stroke/SE, although the magnitude by which it increases the risk of stroke cannot be precisely quantified. Whether a clinical diagnosis of HF is a significant risk factor remains inconclusive, although when the diagnosis is certain (recent decompensation requiring hospitalization), it does seem to be a significant risk factor irrespective of LV systolic function.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 5535 MEDLINE  
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[PMID]: 24309363
[Au] Autor:Baliga V; Gopinath VP; Baliga S; Ramachandra SS; Jithendra KD; Shetty S
[Ad] Address:Reader, Department of Periodontics, Sharad Pawar Dental College and Hospital, Sawangi (Meghe), Wardha, Maharashtra, India, e-mail: baligavs@gmail.com.
[Ti] Title:Intraoral manifestations in a patient with Epidermal nevus syndrome.
[So] Source:J Contemp Dent Pract;14(4):762-5, 2013 Jul-Aug.
[Is] ISSN:1526-3711
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:AIM: To report rare findings of oral and periodontal manifestations in a patient with Epidermal nevus syndrome (ENS). BACKGROUND: The ENS describes the rare association of an epidermal nevus with abnormalities of central nervous system,ocular and skeletal abnormalities. Reports of oral involvement have been few. Also, most of the intraoral lesions have been reported in patients with nevi that do not fulfill the criteria for the diagnosis of ENS. CASE DESCRIPTION: This report describes a case of ENS that, in addition to cutaneous manifestations showed skeletal involvement and intraoral manifestations such as the extension of the nevi on the face intraorally involving the labial mucosa, hypoplasia, hypodontia of teeth and severe periodontal destruction. CONCLUSION: Patients with extensive epidermal nevi and systemic abnormalities should be suspected of having the ENS. Evaluation and management of patients with ENS requires a multidisciplinary team approach involving the dermatologist, pediatrician, ophthalmologist, neurologist, genetist, plastic surgeon and orthopedic services. Although uncommonly described in association with ENS, significant intraoral lesions do occur. Periodontal manifestations as in our patient, which to our knowledge has not been described in association with ENS so far, may also be present. CLINICAL RELEVANCE: Alteration of the response of periodontal tissues to dental plaque in the presence of certain systemic diseases has been reported, but not in association with ENS. Severe periodontal destruction due to exaggerated response to dental plaque was seen in the present case. Hence, emphasis on oral hygiene maintenance in such patients is essential. Patients with ENS must be evaluated periodically as they show a persistent predisposition for the development of tumors.
[Mh] MeSH terms primary: Anodontia/diagnosis
Lip Neoplasms/diagnosis
Neurocutaneous Syndromes/diagnosis
Nevus, Sebaceous of Jadassohn/diagnosis
[Mh] MeSH terms secundary: Adolescent
Alveolar Bone Loss/diagnosis
Facial Neoplasms/diagnosis
Female
Gingival Neoplasms/diagnosis
Humans
Molar, Third/abnormalities
Nevus/diagnosis
Periodontitis/diagnosis
Skin Neoplasms/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:D; IM
[Da] Date of entry for processing:131206
[St] Status:MEDLINE

  8 / 5535 MEDLINE  
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[PMID]: 24139074
[Au] Autor:Righini CA; Petrossi J; Reyt E; Atallah I
[Ad] Address:Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 1, avenue des Maquis-du-Grésivaudan, 38043 Grenoble cedex 09, France; Université Joseph-Fourier, Grenoble I, France; Unité Inserm UJF/U823, centre de recherche Albert-Bonniot, Grenoble, France. Electronic address: crighini@chu-grenoble.fr....
[Ti] Title:An original submandibular approach technique sparing the cervical branch of the facial nerve.
[So] Source:Eur Ann Otorhinolaryngol Head Neck Dis;131(2):143-6, 2014 Apr.
[Is] ISSN:1879-730X
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Many articles and anatomy textbooks accurately describe the anatomy and anatomical variations of the marginal mandibular branch of the facial nerve (VII). This is not, however, true for the cervical branch, damage to which results in paralysis of the platysma and, because of its insertions at the lower lip and labial commissure, in disfigurement, especially when smiling. This may be mistaken for paralysis of the marginal mandibular branch of the facial nerve. Precise anatomical description of the cervical branch of the facial nerve allows certain technical safeguards to be determined which, if adhered to, should reduce the risk of injury, especially during surgical excision of the submandibular gland on a transcervical approach.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1404
[Js] Journal subset:IM
[St] Status:In-Process

  9 / 5535 MEDLINE  
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[PMID]: 24605354
[Au] Autor:Nagler AR; Kim BS; Gormley RH; Chandler LJ; Han JH; Amorosa VK; Kovarik CL
[Ti] Title:Verrucous nodule on the upper lip.
[So] Source:Cutis;93(2):E15-7, 2014 Feb.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Coccidioidomycosis/pathology
Dermatomycoses/pathology
Lip Diseases/pathology
[Mh] MeSH terms secundary: Coccidioidomycosis/diagnosis
Humans
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140307
[St] Status:MEDLINE

  10 / 5535 MEDLINE  
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[PMID]: 24605352
[Au] Autor:Sarmast SA; Fang F; Zic J
[Ad] Address:4243 Bowser Ave, Dallas, TX 75219, USA. shehnazzaman@gmail.com.
[Ti] Title:Vibratory angioedema in a trumpet professor.
[So] Source:Cutis;93(2):E10-1, 2014 Feb.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Angioedema/diagnosis
Hypersensitivity, Immediate/congenital
Lip Diseases/diagnosis
Occupational Diseases/diagnosis
[Mh] MeSH terms secundary: Adult
Humans
Hypersensitivity, Immediate/diagnosis
Male
[Pt] Publication type:CASE REPORTS; LETTER
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140307
[St] Status:MEDLINE


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