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[PMID]: 29522292
[Au] Autor:Ando SM; Moreno RA; Viana PCC; Yamauchi FI
[Ad] Address:Departamento de Radiologia, Hospital das Clínicas da Universidade de São Paulo HC-FMUSP, São Paulo, Brasil.
[Ti] Title:Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma.
[So] Source:Int Braz J Urol;44, 2018 Mar 09.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Renal replacement lipomatosis is a condition characterized by varying degrees of renal parenchymal atrophy and perirenal fibrofatty proliferation secondary to chronic inflammation such as xanthogranulomatous pyelonephritis. In severe cases, imaging findings can be misdiagnosed as retroperitoneal liposarcoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1590/S1677-5538.IBJU.2017.0509

  2 / 12982 MEDLINE  
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[PMID]: 29490659
[Au] Autor:Yasuda T; Suzuki K; Kawaguchi Y; Seki S; Makino H; Watanabe K; Hori T; Yamagami T; Kanamori M; Kimura T
[Ad] Address:Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan. yasuda@med.u-toyama.ac.jp.
[Ti] Title:Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis.
[So] Source:BMC Musculoskelet Disord;19(1):66, 2018 03 01.
[Is] ISSN:1471-2474
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Lumbar epidural lipomatosis (LEL) is characterized by abnormal accumulation of unencapsulated adipose tissue in the spinal epidural space. Such accumulation compresses the dural sac and nerve roots, and results in various neurological findings. However, the pathophysiology of LEL remains unclear. This study examined the associations between imaging and clinical findings in detail, and investigated the mechanisms underlying symptom onset by measuring intraoperative epidural pressures in LEL. METHODS: Sixteen patients (all men; mean age, 68.8 years) were enrolled between 2011 and 2015. Mean body mass index was 26.5 kg/m . Four cases were steroid-induced, and the remaining 12 cases were idiopathic. All patients presented with neurological deficits in the lower extremities. Cauda equina syndrome (CES) alone was seen in 8 patients, radiculopathy alone in 4, and both radiculopathy and CES (mixed CES) in 4. All patients subsequently underwent laminectomy with epidural lipomatosis resection and were followed-up for more than 1 year. We investigated the clinical course and imaging and measured epidural pressures during surgery. RESULTS: Subjective symptoms improved within 1 week after surgery. Mean Japanese Orthopaedic Association (JOA) score was 15.2 ± 2.8 before surgery, improving to 25.4 ± 2.5 at 1 year after surgery. On magnetic resonance imaging, all lipomatosis lesions included the L4-5 level. On preoperative computed tomography, saucerization of the laminae was not observed in radiculopathy cases, whereas saucerization of the posterior vertebral body was observed in all radiculopathy or mixed CES cases. Intraoperative epidural pressures were significantly higher than preoperative subarachnoid pressures. The results suggest that high epidural pressure resulting from the proliferation of adipose tissue leads to saucerization of the lumbar spine and subsequent symptoms. CONCLUSIONS: Clinical courses were satisfactory after laminectomy. In LEL, epidural pressure increases and symptoms develop through the abnormal proliferation of adipose tissue. Higher epidural pressures induce saucerization of the laminae and/or posterior vertebral body. Furthermore, the direction of proliferative adipose tissue (i.e., site of saucerization) might be related to the types of neurological symptoms.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1186/s12891-018-1988-8

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[PMID]: 29429160
[Au] Autor:Zhao M; Wang YB; Yan YJ; Wang W; Ru GQ; He XL
[Ad] Address:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Title:[Clinicopathologic features of atypical spindle cell lipomatous tumor].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):99-104, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. All three patients were adult males, aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous soft tissue in the head and neck, one was located in the left primary bronchus and one in the latissimus dorsi muscle. Grossly, all three tumors were circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed a focally infiltrative front. These tumors were composed of variable proportions of spindle-shaped and adipocytic cells in a background of variable fibrous and edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed predominately of spindle tumor cells, one of adipocytic cells, and one of equally mixed cell populations. The spindle tumor cells were generally bland-appearing with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was not seen in neither the spindle cells nor the adipocytic cells. By immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells was noted in all cases, definite loss of Rb expression was noted in one of three cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, STAT6, SOX10, CD99, bcl-2, ß-catenin, CD117, GFAP, CK, EMA, SMA and desmin were negative. FISH of MDM2 was done in two cases, and both showed no amplification. The ASLT in the head and neck had two recurrences during 17 months of follow-up, whereas the tumor in the latissimus dorsi was free of disease during 33 months of follow-up. ASLT is a rare subtype of low-grade adipocytic neoplasm and is distinctive from atypical lipomatous tumor/well-differentiated liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a continuous spectrum. ASLT needs to be distinguished from a series of benign and malignant soft tissue tumors.
[Mh] MeSH terms primary: Bronchial Neoplasms/pathology
Head and Neck Neoplasms/pathology
Lipoma/pathology
Muscle Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Bronchial Neoplasms/chemistry
Head and Neck Neoplasms/chemistry
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lipoma/chemistry
Liposarcoma/chemistry
Liposarcoma/pathology
Male
Middle Aged
Muscle Neoplasms/chemistry
Neoplasm Recurrence, Local
S100 Proteins/analysis
STAT6 Transcription Factor/analysis
Superficial Back Muscles
beta Catenin/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (CTNNB1 protein, human); 0 (S100 Proteins); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (beta Catenin)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.004

  4 / 12982 MEDLINE  
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[PMID]: 29256430
[Au] Autor:Stimmelmayr R; Rotstein D; Seguel M; Gottdenker N
[Ad] Address:North Slope Borough Department of Wildlife Management, Barrow, Alaska 99723, USA.
[Ti] Title:Hepatic lipomas and myelolipomas in subsistence-harvested bowhead whales Balaena mysticetus, Alaska (USA): a case review 1980-2016.
[So] Source:Dis Aquat Organ;127(1):71-74, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:We describe a case series of benign hepatic fatty tumors in 10 subsistence-harvested bowhead whales. Microscopic features included lipomatous and myelolipomatous masses. Extensive atrophy and/or destruction of hepatic parenchyma was not observed. No other significant disease was present except in an animal with unrelated chronic pleuritis. Based on our longitudinal case series (1980-2016) which identified 1-2 hepatic lipomas and myelolipomas in landed whales annually at Barrow, Alaska (USA), since 2012, hepatic lipomas and myelolipomas are occasionally seen in hunter-harvested bowhead whales. A conservative estimate for the percentage of bowhead whales with hepatic fatty tumors in landed whales in Barrow from 2012 to 2016 was 6% (7/111). The pathogenesis and exact cell origin of these benign fatty tumors in bowhead whales is undetermined. Assessment of further cases is warranted to better define the tissue distribution and pathogenesis of these tumors in bowhead whale liver.
[Mh] MeSH terms primary: Lipoma/veterinary
Liver Neoplasms/veterinary
Myelolipoma/veterinary
Whales
[Mh] MeSH terms secundary: Alaska
Animals
Female
Lipoma/epidemiology
Lipoma/pathology
Liver Neoplasms/epidemiology
Male
Myelolipoma/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03186

  5 / 12982 MEDLINE  
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[PMID]: 29181924
[Au] Autor:Vetrhus M; Fjetland L
[Ti] Title:Intravenøst lipom.
[So] Source:Tidsskr Nor Laegeforen;137(22), 2017 11 28.
[Is] ISSN:0807-7096
[Cp] Country of publication:Norway
[La] Language:nor
[Mh] MeSH terms primary: Computed Tomography Angiography
Lipoma/diagnostic imaging
Vascular Neoplasms/diagnostic imaging
[Mh] MeSH terms secundary: Aged
Brachiocephalic Veins/diagnostic imaging
Brachiocephalic Veins/pathology
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:171129
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0646

  6 / 12982 MEDLINE  
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[PMID]: 29252657
[Au] Autor:Kojima K; Iwanami A; Mikami S; Ishii K; Matsumoto M; Nakamura M
[Ad] Address:Departments of Orthopedic Surgery (K.K., A.I., K.I., M.M., and M.N.) and Pathology (S.M.), Keio University School of Medicine, Tokyo, Japan.
[Ti] Title:An Intramedullary Osteolipoma of the Upper Thoracic Spinal Cord: A Case Report.
[So] Source:JBJS Case Connect;6(3):e80, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE: We present a rare case of an intramedullary osteolipoma without any extramedullary connections or coexisting spinal dysraphism. A 48-year-old woman presented with back pain and pain around the lateral aspect of the left thigh. Magnetic resonance imaging (MRI) revealed a heterogeneous hyperintense and hypointense region on T1 and T2-weighted imaging. A cavernous hemangioma was suspected, and the patient was admitted for surgical resection. The histological diagnosis was an intramedullary osteolipoma. CONCLUSION: MRI with fat suppression and computed tomography are recommended for the diagnosis of an intramedullary osteolipoma, but a definitive diagnosis requires histological examination.
[Mh] MeSH terms primary: Lipoma/diagnosis
Spinal Cord Neoplasms/diagnosis
[Mh] MeSH terms secundary: Female
Humans
Lipoma/pathology
Middle Aged
Spinal Cord Neoplasms/pathology
Thoracic Vertebrae/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00025

  7 / 12982 MEDLINE  
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[PMID]: 29405131
[Au] Autor:Mohanty P; Vivekanandh K; Dash G; Mohapatra L
[Ad] Address:Department of Skin and VD, S.C.B. Medical College and Hospital, Cuttack, Odisha, India.
[Ti] Title:Madelung's disease: A benign symmetric lipomatosis.
[So] Source:Indian J Dermatol Venereol Leprol;84(2):190-191, 2018.
[Is] ISSN:0973-3922
[Cp] Country of publication:India
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Data-Review
[do] DOI:10.4103/ijdvl.IJDVL_126_17

  8 / 12982 MEDLINE  
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[PMID]: 29390483
[Au] Autor:Kim JH; Yoon HH; Jeong SH; Woo HS; Lee WS; Choi SJ; Kim SG; Ha SY; Kwon KA
[Ad] Address:Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon.
[Ti] Title:Spontaneous peeled ileal giant lipoma caused by lower gastrointestinal bleeding: A case report.
[So] Source:Medicine (Baltimore);96(51):e9253, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Gastrointestinal subepithelial tumors (SETs) with endoscopic features such as ulceration, a red color change, a peeled mucosal layer, and spontaneous bleeding could have malignant potential. However, we encountered a case of a lipoma that presented features different from the generally known features of gastrointestinal SETs. Therefore, we report an interesting rare case of a terminal ileal giant lipoma with a unique feature of spontaneous peeled ulceration on the surface on endoscopy that caused gastrointestinal bleeding. PATIENT: An 82-year-old woman with a 1-week history of abdominal pain and hematochezia presented to our hospital. DIAGNOSES: Ileocolonoscopy revealed a SET with a peeled surface and erythematous and ulcerative mucosal changes as well as exposed a submucosal mass at the terminal ileum. Macroscopically, the lesion appeared as a yellowish pedunculated polypoid mass measuring 3 × 2 cm with a peeled mucosal ulceration. Histopathological findings revealed a submucosal lipoma of the terminal ileum. INTERVENTION: We thought that the endoscopic finding indicated malignant SETs or those with malignant potential rather than benign SETs. Therefore, the patient underwent an elective laparoscopic ileocecectomy. LESSONS: We encountered a lipoma that did not present with the typical features of gastrointestinal SETs. Our findings suggest that clinicians should consider that benign SETs in the terminal ileum may present with various endoscopic findings similar to those of malignant SETs, which can cause fatal symptoms and signs.
[Mh] MeSH terms primary: Gastrointestinal Hemorrhage/etiology
Ileum/surgery
Intestinal Neoplasms/pathology
Laparoscopy/methods
Lipoma/pathology
[Mh] MeSH terms secundary: Abdominal Pain/diagnosis
Abdominal Pain/etiology
Aged, 80 and over
Capsule Endoscopy/methods
Female
Follow-Up Studies
Gastrointestinal Hemorrhage/surgery
Humans
Ileum/pathology
Intestinal Mucosa/pathology
Intestinal Mucosa/surgery
Intestinal Neoplasms/complications
Intestinal Neoplasms/diagnostic imaging
Intestinal Neoplasms/surgery
Lipoma/complications
Lipoma/diagnostic imaging
Lipoma/surgery
Risk Assessment
Severity of Illness Index
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009253

  9 / 12982 MEDLINE  
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[PMID]: 29431910
[Au] Autor:Al Ghazal P; Grönemeyer LL; Schön MP
[Ad] Address:Department of Dermatology, Venerology and Allergology, University Medical Center, Göttingen, Germany.
[Ti] Title:Lipomatoses.
[So] Source:J Dtsch Dermatol Ges;, 2018 Feb 12.
[Is] ISSN:1610-0387
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption. In some cases, mitochondrial dysfunctions have been detected. Lipomatoses may be solitary, but may also be associated with other symptoms or illnesses (comorbidity). Effective drug therapies are not known, but surgical procedures can alleviate the symptoms. Lipomatosis dolorosa, which can be distinguished from BSL, occurs predominantly in middle-aged women and is characterized by proliferation of adipose tissue and severe pain in the affected areas. Various differential diagnoses and concomitant illnesses need to be considered, in particular depression. There are no evidence-based recommendations for therapy. Repetitive lidocaine infusions can achieve temporary improvement. Recurrence after surgical intervention is not uncommon, but long-term success is also possible.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1111/ddg.13460

  10 / 12982 MEDLINE  
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[PMID]: 29414957
[Au] Autor:Muñoz-Montufar JP; Rayo-Mares JD; Reyes-Cuayahuitl A; Pacheco-Rosas DO; Rangel-Ramírez MP
[Ad] Address:Servicio de Neurología Pediátrica; Unidad Médica de Alta Especialidad Hospital de Pediatría Dr. Silvestre Freunk Freund, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, México.
[Ti] Title:Lipomatosis encefalocraneocutánea: reporte de caso.
[So] Source:Gac Med Mex;153(7):915-918, 2017.
[Is] ISSN:0016-3813
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:The encephalocraniocutaneous lipomatosis (ECCL), also known as Fishman or Haberland syndrome, is a rare neurocutaneous syndrome of unknown etiology. Clinically characterized by skin, eye and central nervous system lesions. We present the case of a 7-year-old female who presents to the outpatient clinic of Pediatric Neurology because of the presence of seizures detecting clinical and neuroimaging manifestations compatible with ECCL. The objective of this article is to present the case because of its rare presentation and the variety of alterations found in the tomography.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Data-Review
[do] DOI:10.24875/GMM.17002833


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