Database : MEDLINE
Search on : Lithiasis [Words]
References found : 5737 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 574 go to page                         

  1 / 5737 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 25060549
[Au] Autor:Medina-Escobedo M; González-Herrera L; Villanueva-Jorge S; Martín-Soberanis G
[Ad] Address:Research Unit on Kidney Diseases, General Hospital "Dr. Agustin O'Horan", Health Services of Yucatan, Av. Itzáes por Jacinto Canek s/n, Col. Centro, 97000, Mérida, Yucatán, Mexico, marthamedinaescobedo@hotmail.com.
[Ti] Title:Metabolic abnormalities and polymorphisms of the vitamin D receptor (VDR) and ZNF365 genes in children with urolithiasis.
[So] Source:Urolithiasis;42(5):395-400, 2014 Oct.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Composition of urinary stones in children from Yucatán, México, is calcium and uric acid. Polymorphisms in VDR and ZNF365 genes have been associated to calcium and uric acid lithiasis, respectively. We evaluated the association of polymorphisms TaqI and FokI of VDR gene and Ala62Thr of ZNF365 gene with the metabolic disorders (MD) in children with urolithiasis (UL). We included 109 children with UL. Creatinine, calcium, phosphorus, magnesium, uric acid, oxalates and citrates were measured in fresh urine. Urinary indices were calculated for determining the MD. VDR and ZNF365 polymorphisms were determined by PCR-RFLP. Genotype frequencies were compared with the frequency of MD and with the averages of excretion of the analytes, using the statistical package STATA 11.0. The most frequent MD were hypocitraturia (35.8 %) and hyperuricosuria (22.9 %). The comparison of genotype frequencies with the frequency of MD did not show significant differences (p > 0.05). The comparison of the urinary excretion averages of analytes with respect to the genotype showed that GG homozygotes have higher concentrations of uric acid and citrate than AG heterozygotes (p = 0.03), and that fF heterozygotes have lower concentrations of citrate (p = 0.009). Hypocitraturia and hyperuricosuria were the most common metabolic disorders. The frequency of MD is not associated with polymorphisms. However, in children with urolithiasis of Yucatan, GG homozygotes excrete higher concentrations of uric acid and citrates, and fF heterozygotes have lower concentrations of citrates.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s00240-014-0683-y

  2 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24954866
[Au] Autor:Barbier L; Souche R; Slim K; Ah-Soune P
[Ad] Address:Chirurgie Digestive et Transplantation Hépatique, Hôpital La Conception, Assistance publique-Hôpitaux de Marseille, Aix-Marseille Université, 147, boulevard Baille, 13385 Marseille cedex 5, France. Electronic address: louisebarbier@hotmail.fr....
[Ti] Title:Long-term consequences of bile duct injury after cholecystectomy.
[So] Source:J Visc Surg;151(4):269-79, 2014 Sep.
[Is] ISSN:1878-7886
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Late complications arising after bile duct injury (BDI) include biliary strictures, hepatic atrophy, cholangitis and intra-hepatic lithiasis. Later, fibrosis or even secondary biliary cirrhosis and portal hypertension can develop, enhanced by prolonged biliary obstruction associated with recurrent cholangitis. Secondary biliary cirrhosis resulting in associated hepatic failure or digestive tract bleeding due to portal hypertension is a substantial risk factor for morbidity and mortality after bile duct repair. Parameters that determine the management of late complications of BDI include the type of biliary injury, associated vascular injury, hepatic atrophy, the presence of intra-hepatic strictures or lithiasis, repetitive infectious complications, the quality of underlying parenchyma (fibrosis, secondary biliary cirrhosis) and the presence of portal hypertension. Endoscopic drainage is indicated for patients with uncontrolled acute sepsis, patients at high operative risk, patients with cirrhosis who are not eligible for liver transplantation and patients who have previously undergone several attempts at repair. Roux-en-Y hepaticojejunostomy, whether de novo or as an iterative repair, is the technique of reference for post-cholecystectomy BDI. Hepatic resection is indicated in only rare instances, mainly in case of extended hilar stricture, multiple stone retention in one sector of the liver or in patients for whom the repair is deemed technically difficult. Liver transplantation is indicated only in exceptional circumstances, when secondary biliary cirrhosis is associated with liver failure and portal hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process

  3 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 23809173
[Au] Autor:Gouzien C; Valiamé A; Misdrahi D
[Ad] Address:Centre de référence régional des pathologies anxieuses et de la dépression, centre expert dépression résistante fondation fondamental, Bordeaux cedex, France; Université Bordeaux Segalen, 146, rue Léo-Saignat, 33077 Bordeaux cedex, France; Pôle de psychiatrie adulte 347, centre hospitalier Charles-Perrens, 121, rue de la Béchade, 33076 Bordeaux cedex, France.
[Ti] Title:Parotidite induite par la clozapine : à propos d'un cas. [Clozapine-induced parotitis: a case study].
[So] Source:Encephale;40(1):81-5, 2014 Feb.
[Is] ISSN:0013-7006
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: Clozapine is the drug of choice for patients with an unsatisfactory response to routine antipsychotic treatment. Side effects such as sedation, weight gain, hypotension and hypersialorrhea are frequently reported whereas clozapine-induced parotitis is a less known complication. CASE REPORT: We report the case of a 32-year-old woman with a refractory schizoaffective disorder, bipolar type. The failure to respond to at least two well-conducted antipsychotic trials with flupentixol and risperidone, led clinicians to prescribe clozapine, which was started three years earlier. Since its introduction, clozapine induced sialorrhea, which has been managed until now with anticholinergic medication. Recently, Mrs B. was hospitalized for a new relapse. Once treatment compliance checked (good level of plasmatic dosage), we decided to increase the dose of clozapine from 350 mg/d to 500 mg/d. Twenty days later, Mrs B. exhibited improvement of symptoms but complained of acute bilateral auricular pain and odynophagia. The bilateral and comparative clinical exam displayed a bilateral filling of the retromandibular depression, the painful swelling of the parotid gland, along with ptyalism and a slight inflammatory oedema of the Stenon duct orifice. Mrs B. was apyretic, with physiological constants within the limits of normal values. The biological analyses displayed a discrete inflammatory syndrome (mild hyperleucocytosis and anemia), a negative mumps IgM test and positive mumps IgG test, and a 1050 ng/mL clozapine blood level. Once viral parotitis was ruled out, the involvement of clozapine was evoked. Symptomatic medication was prescribed with per os analgesic (paracetamol) and antiseptic mouthwash (Éludril). Clozapine dosage was lowered to 400 mg/d. A week later, clinical examination confirmed improvement of the medical and psychiatric conditions. DISCUSSION: We report the case of a patient who developed a parotitis following clozapine dose adjustment. Clozapine induced parotitis was retained once the infectious and other organic etiologies had been ruled out. Previous cases of clozapine-induced parotitis have already been reported and we have some arguments to suspect this etiology in our case. First, Mrs B. experienced more hypersialorrhea with the increase in clozapine dosage. Second, the anticholinergic medication was interrupted 3 days before the episode of parotitis. Two main pathophysiological hypotheses, immune and inflammatory, have already been proposed to explain clozapine-induced parotitis. In the former, the immunomodulating properties of clozapine may sensitize the mononuclear blood cells, leading to the sialadenitis. The latter hypothesis is the more documented and proposes that clozapine-induced hypersialorrhea may be responsible for a chronic inflammatory state that can lead to the formation of a parotid lithiasis and consequently parotitis. This case report illustrates clozapine induced-parotitis, a poorly known complication of this compound. Clinicians should be aware of its hypersialorrhea and inflammatory consequences in order to better prevent the occurrence of this complication.
[Mh] MeSH terms primary: Bipolar Disorder/drug therapy
Clozapine/adverse effects
Parotitis/chemically induced
Psychotic Disorders/drug therapy
[Mh] MeSH terms secundary: Adult
Bipolar Disorder/diagnosis
Bipolar Disorder/psychology
Clozapine/therapeutic use
Dose-Response Relationship, Drug
Female
Humans
Psychotic Disorders/diagnosis
Psychotic Disorders/psychology
Recurrence
Sialorrhea/chemically induced
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:J60AR2IKIC (Clozapine)
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140224
[St] Status:MEDLINE

  4 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 23981680
[Au] Autor:Rellum DM; Feitz WF; van Herwaarden AE; Schreuder MF
[Ad] Address:Department of Pediatric Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands....
[Ti] Title:Pediatric urolithiasis in a non-endemic country: a single center experience from The Netherlands.
[So] Source:J Pediatr Urol;10(1):155-61, 2014 Feb.
[Is] ISSN:1873-4898
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To provide insight in causative factors of pediatric urolithiasis in The Netherlands, a non-endemic country. PATIENTS AND METHODS: Data from 71 children with urolithiasis and stone analyses between 1996 and 2010 in the Radboud University Nijmegen Medical Centre were studied retrospectively. Patients (48 boys, 23 girls, ratio 2.1:1) were aged 0.5-18.3 years (mean 8.8, SD 5.6). All stone analyses were performed with FTIR spectroscopy. RESULTS: Of the 49 patients with metabolic analysis, 78% showed one (n = 15) or more (n = 23) metabolic abnormalities. Forty-seven percent had hypercalciuria (n = 23), 31% had hyperoxaluria (n = 15), 29% hypocitraturia (n = 14), 10% hyperuricosuria (n = 5), 10% cystinuria (n = 5), and 6% had hypomagnesiuria (n = 3). Sixty-one percent of the stones were composed of calcium phosphate, calcium oxalate, or a combination of those. Twenty-six percent consisted of pure or mixed magnesium ammonium phosphate, 8.3% pure or mixed urate, and 8.3% cystine. CONCLUSION: Children with urolithiasis in The Netherlands show stone composition similar to other Western European countries. However, a high percentage of metabolic abnormalities (78%) was found, indicating the need for extensive evaluation of pediatric urolithiasis to find underlying causes and thereby prevent stone recurrences. A close collaboration between a pediatric nephrologist and urologist is mandatory for optimal surgical and medical treatment.
[Mh] MeSH terms primary: Urolithiasis/etiology
Urolithiasis/metabolism
[Mh] MeSH terms secundary: Adolescent
Calcium Oxalate/analysis
Calcium Phosphates/analysis
Child
Child, Preschool
Female
Humans
Infant
Male
Netherlands/epidemiology
Urinary Calculi/chemistry
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Calcium Phosphates); 2612HC57YE (Calcium Oxalate); 97Z1WI3NDX (calcium phosphate)
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140217
[St] Status:MEDLINE

  5 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 23953243
[Au] Autor:Kirejczyk JK; Porowski T; Filonowicz R; Kazberuk A; Stefanowicz M; Wasilewska A; Debek W
[Ad] Address:Department of Pediatric Surgery, Medical University of Bialystok, Poland. Electronic address: kkirejczyk@wp.pl....
[Ti] Title:An association between kidney stone composition and urinary metabolic disturbances in children.
[So] Source:J Pediatr Urol;10(1):130-5, 2014 Feb.
[Is] ISSN:1873-4898
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine kidney stone composition in children and to correlate stone fractions with urinary pH and metabolic urinary risk factors. PATIENTS AND METHODS: We studied 135 pediatric patients with upper urinary tract lithiasis in whom excreted or extracted stones were available for analyses. Composition of stones was analyzed. A 24-hour urine assessment included volume, pH and daily excretions of calcium, oxalate, uric acid, cystine, creatinine, phosphate, magnesium and citrate. RESULTS: Calcium oxalate was the major component of 73% stones, followed by struvite (13%) and calcium phosphate (9%). Uric acid was present in almost half of stones, but in rudimentary amounts. The calcium oxalate content in calculi showed a strong relationship with calciuria, and moderate association with oxaluria, magnesuria and acidification of urine. The percent content of struvite presented reverse and lower correlations with regard to the above parameters. Calcium phosphate stone proportion had low associations with urinary risk factors. CONCLUSIONS: Calciuria, oxaluria, magnesuria and low urine pH exerted the biggest influence on calcium oxalate content in pediatric renal stones. Relationships of urinary risk factors with calculi calcium phosphate content were of unclear significance. Urinary citrate excretion did not significantly correlate with kidney stone composition in children.
[Mh] MeSH terms primary: Kidney Calculi/chemistry
[Mh] MeSH terms secundary: Adolescent
Calcium Oxalate/analysis
Calcium Phosphates/analysis
Child
Female
Humans
Hydrogen-Ion Concentration
Magnesium Compounds/analysis
Male
Phosphates/analysis
Risk Factors
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Calcium Phosphates); 0 (Magnesium Compounds); 0 (Phosphates); 15490-91-2 (struvite); 2612HC57YE (Calcium Oxalate); 97Z1WI3NDX (calcium phosphate)
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140217
[St] Status:MEDLINE

  6 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25214292
[Au] Autor:Laclergerie F; Jacquemet B; Guichard G; Bernardini S; Chabannes E; Martin L; Pastori J; Bailly V; Bittard H; Kleinclauss F
[Ad] Address:Département d'urologie et de transplantation rénale, CHU Jean-Minjoz, université de Franche-Comté, 25030 Besançon, France....
[Ti] Title:Urétérorénoscopie souple avec laser Holmium-YAG dans la prise en charge des lithiases urinaires chez le patient obèse: résultats d'une cohorte monocentrique. [Flexible ureterorenoscopy in obese patients: results from a large monocenter cohort].
[So] Source:Prog Urol;24(10):634-9, 2014 Sep.
[Is] ISSN:1166-7087
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:OBJECTIVE: To analyze results and morbidity after flexible ureterorenoscopy (fURS) in patients with a body mass index (BMI)>30 kg/m² and to compare with results obtained in a large cohort of non-obese patients. METHODS: We conducted a retrospective monocenter study including all fURS for urinary lithiasis performed in our institution between January 2004 and December 2010. During the study period, 497 procedures were performed. Twenty-three had to be excluded because of missing data on BMI. Thus, a total of 474 procedures were included in the final analysis, 93 for obese patients (OP) and 381 for non-obese patients (NOP). Characteristics of the patients, stones and procedures were analyzed. Success was defined as clear imaging (completely stone-free) on renal tomography and ultrasonography. RESULTS: Mean BMI was 33.5 ± 0.3 in OP vs 23.9 ± 0.1 kg/m² in NOP (P<0.0001). Mean stone size, location, and composition were not significantly different between groups. Technical aspects (operative time, ureteral dilatation, access sheath, monobloc extraction) were also similar in OP and NOP. The immediate (63.5% for OP vs 66.1% in NOP, P=0.62) and follow-up (65.1% for OP vs 71% in NOP, P=0.26) stone-free rate were not significantly different between the groups. For stone size<1cm, SFR raised to 77% in OP vs 83% in NOP (P=0.28). The rate of minor complications Clavien II was similar in OP (7.5%) and NOP (12%). No major complication (Clavien III or IV) was observed. CONCLUSION: fURS is a safe and efficient option for the management of urinary lithiasis in obese patients.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24568103
[Au] Autor:Plesman RL; Norris A; Ringwood PB
[Ad] Address:Veterinary Emergency Clinic and Referral Center, 920 Yonge St, Ste 117, Toronto, ON M4W 3C7, Canada.
[Ti] Title:What is your diagnosis? Pancreatolithiasis.
[So] Source:J Am Vet Med Assoc;244(6):647-9, 2014 Mar 15.
[Is] ISSN:1943-569X
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Cat Diseases/diagnosis
Lithiasis/veterinary
Pancreatic Diseases/veterinary
[Mh] MeSH terms secundary: Animals
Cat Diseases/pathology
Cats
Female
Lithiasis/diagnosis
Lithiasis/pathology
Lithiasis/surgery
Pancreatic Diseases/diagnosis
Pancreatic Diseases/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:140226
[St] Status:MEDLINE
[do] DOI:10.2460/javma.244.6.647

  8 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25332855
[Au] Autor:Arrellano-Valdez F; Urrutia-Osorio M; Arroyo C; Soto-Vega E
[Ad] Address:Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, 21 sur 1103, Barrio de Santiago, Puebla, Puebla C.P 72410 México....
[Ti] Title:A comprehensive review of urologic complications in patients with diabetes.
[So] Source:Springerplus;3:549, 2014.
[Is] ISSN:2193-1801
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Diabetes Mellitus (DM) is a chronic disease characterized by hyperglycemia, as a result of abnormal insulin production, insulin function, or both. DM is associated with systemic complications, such as infections, neuropathy and angiopathy, which involve the genitourinary tract. The three most significant urologic complications include: bladder cystopathy, sexual dysfunction and urinary tract infections. Almost half of the patients with DM have bladder dysfunction or cystopathy, which can be manifested in women as hypersensitivity (in 39-61% of the diabetic women) or neurogenic bladder. In males it can be experienced as lower urinary tract symptoms (in 25% of diabetic males with a nearly twofold increased risk when seen by age groups). Additionally, an increased prostate volume affects their micturition as well as their urinary tract. Involving sexual dysfunction in women, it includes reduced libido, decreased arousal, clitoral erectile dysfunction and painful or non-sensitive intercourse; and in diabetic males it varies from low libido, ejaculatory abnormalities and erectile dysfunction. Globally, sexual disorders have a prevalence of 18-42%. Erectile dysfunction is ranked as the third most important complication of DM. Urinary tract infections are observed frequently in diabetic patients, and vary from emphysematous infections, Fournier gangrene, staghorn infected lithiasis to repetitive bacterial cystitis. The most frequent finding in diabetic women has been lower urinary tract infections. Because of the high incidence of obesity worldwide and its association with diabetes, it is very important to keep in mind the urologic complication associated with DM in patients, in order to better diagnose and treat this population.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1410
[Cu] Class update date: 141023
[Lr] Last revision date:141023
[Da] Date of entry for processing:141021
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/2193-1801-3-549

  9 / 5737 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 24355188
[Au] Autor:Maiolo V; Savastio G; Modugno GC; Barozzi L
[Ad] Address:Radiology Department, S.Orsola-Malpighi University Hospital; Bologna, Italy - maiolo.vincenzo@yahoo.it.
[Ti] Title:Relationship between multidetector CT imaging of the vestibular aqueduct and inner ear pathologies.
[So] Source:Neuroradiol J;26(6):683-92, 2013 Dec.
[Is] ISSN:1971-4009
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:This study investigated the relationships between morphological changes in the vestibular aqueduct (VA) in different inner ear pathologies. Eighty-eight patients (34 males and 54 females, ranging from seven to 88 years of age; average age 49.2 years) with cochleovestibular disorders underwent temporal bone CT (with a 64-channel helical CT system according to temporal bone protocol parameters; 0.6 mm slice thickness, 0.6 mm collimation, bone reconstruction algorithm). All patients with cochleovestibular disorders who underwent temporal bone CT had been previously divided into six different suspected clinical classes: A) suspected pathology of the third window; B) suspected retrocochlear hearing loss; C) defined Ménière's disease; D) labyrinth lithiasis; E) recurrent vertigo. On CT images we analyzed the length, width and morphology of the VA, contact between the VA and the jugular bulb (JB), the thickness of the osseous capsule covering the semicircular canals, the pneumatization rate of the temporal bone and the diameter of the internal auditory canal. At the end of the diagnostic work-up all patients were grouped into six pathological classes, represented as follow: 1) benign paroxysmal positional vertigo (BPPV), 2) recurrent vertigo (RV), 3) enlarged vestibular aqueduct syndrome (EVAS), 4) sudden or progressive unilateral sensorineural hearing loss (SNHL), 5) superior semicircular canal dehiscence syndrome (SSCD), 6) recurrent vestibulocochlear symptoms in Ménière's disease. We evaluated 176 temporal bones in 88 patients. The VA was clearly visualized in 166/176 temporal bones; in ten ears the VA was not visualized. In 14 ears (11 patients, in three of whom bilaterally) we found an enlarged VA while in 31 ears the VA was significantly narrower. In 16 ears a dehiscence of the JB with the vestibular or cochlear aqueduct was noted. In all six patients with suspected EVAS we found a AV wider than 1.5 mm on CT scans; moreover CT identified four patients with large VA and ill-defined clinical symptoms. Most patients with BPPV (11 patients, Class 1) we did not find any VA abnormalities on CT scans, confirming the clinical diagnosis in ten patients; in the remaining patients we found an enlarged VA, not clinically suspected. In the RV class (eight patients, Class 2) we found three patients with negative CT scans, two patients with narrow aqueduct and subsequently reclassified as Ménière's disease patients, and three patients with ectasic JB dehiscence with the VA. In patients suffering from SNHL we found no statistically significant correlation with the morphological abnormalities. The clinical suspicion of SSCD was confirmed by CT in 11/13 patients (84.6 %); in addition another seven patients showed a thinning or dehiscence of the superior semicircular canals as the prevailing alteration on CT scans, and were reclassified in this group. Ménière's disease symptoms were correlated with a VA alteration in more than half of the cases; the most striking finding in this class was that the VA was significantly narrower (21 patients). Our study demonstrates that alterations of the VA morphology are not only related to EVAS but are also found in other inner ear pathologies such as Ménière's disease. Furthermore, MDCT may confirm the presence of correlations between the morphology of inner ear structures such as VA, semicircular canals or JB dehiscence, and alterations of vestibulocochlear function.
[Mh] MeSH terms primary: Labyrinth Diseases/pathology
Labyrinth Diseases/radiography
Tomography, X-Ray Computed
Vestibular Aqueduct/pathology
Vestibular Aqueduct/radiography
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Humans
Male
Middle Aged
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1402
[Cu] Class update date: 141022
[Lr] Last revision date:141022
[Js] Journal subset:IM
[Da] Date of entry for processing:131220
[St] Status:MEDLINE

  10 / 5737 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 25310585
[Au] Autor:Zhang H; Li N; Li K; Li P
[Ad] Address:Department of Urology, Yantai Hill Hospital, Yantai, Shandong 264001, P.R. China....
[Ti] Title:Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats.
[So] Source:Mol Med Rep;10(6):3157-62, 2014 Dec.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease, which affects 10­12% of the population in industrialized countries. In males, the highest prevalence of the disease occurs between the age of 20 and 40 years, while in females, the highest incidence of the disease occurs later. Previous studies have shown that long­term exposure to oxalate is toxic to renal epithelial cells and results in oxidative stress. In the present study, a methanolic extract of aerial parts of Urtica dioica was screened for antiurolithiatic activity against ethylene glycol and ammonium chloride­induced calcium oxalate renal stones in male rats. In the control rats, ethylene glycol and ammonium chloride administration was observed to cause an increase in urinary calcium, oxalate and creatinine levels, as well as an increase in renal calcium and oxalate deposition. Histopathological observations revealed calcium oxalate microcrystal deposits in the kidney sections of the rats treated with ethylene glycol and ammonium chloride, indicating the induction of lithiasis. In the test rats, treatment with the methanolic extract of Urtica dioica was found to decrease the elevated levels of urinary calcium, oxalate and creatinine, and significantly decrease the renal deposition of calcium and oxalate. Furthermore, renal histological observations revealed a significant reduction in calcium oxalate crystal deposition in the test rats. Phytochemical analysis of the Urtica dioica extract was also performed using liquid chromatography­electrospray ionization tandem mass spectrometry and high-performance liquid chromatography with photodiode array detection, to determine the chemical composition of the extract. The eight chemical constituents identified in the extract were protocatechuic acid, salicylic acid, luteolin, gossypetin, rutin, kaempferol­3­O­rutinoside, kaempferol­3­O­glucoside and chlorogenic acid. In conclusion, the results of the present study suggest that Urtica dioica has strong antiurolithiatic activity and may have potential as a natural therapeutic agent for various urological disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3892/mmr.2014.2610


page 1 of 574 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information