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[PMID]: 25623670
[Au] Autor:Wu W; Yang D; Tiselius HG; Ou L; Mai Z; Chen K; Zhu H; Xu S; Zhao Z; Zeng G
[Ad] Address:Department of Urology, Minimally Invasive Surgery Center, the First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou, China. Electronic address: wwqwml@163.com....
[Ti] Title:Collection and storage of urine specimens for measurement of urolithiasis risk factors.
[So] Source:Urology;85(2):299-303, 2015 Feb.
[Is] ISSN:1527-9995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate how different methods for storage and preservation of urine samples affected the outcome of analysis of risk factors for stone formation. METHODS: Spot urine samples were collected from 21 healthy volunteers. Each fresh urine sample was divided into ten 10-mL aliquots: 2 without preservative, 2 with thymol, 2 with toluene, 2 with hydrochloric acid (HCl), and 2 with sodium azide. One sample of each pair was stored at 4 °C and the other at room temperature. The concentrations of calcium, magnesium, sodium, phosphate, urate, oxalate, citrate, and pH in each urine sample were analyzed immediately after collection (0 hour) and after 24 and 48 hours. RESULTS: There were no significant differences in calcium, oxalate, magnesium, phosphate, sodium, urate or pH (without acidification) between samples with different preservation methods (P >.05). Urinary citrate, however, was significantly lower in the urine collected with HCl than when other preservatives were used, both at room temperature and at 4 °C. Urine pH was significantly higher after 48 hours than after 24 hours, whether the samples were stored at room temperature or at 4 °C. CONCLUSION: Antibacterial preservatives (eg, thymol or toluene) can be recommended as preservatives for 24-hour urine collections. Ideally, the samples should be stored at 4 °C. When HCl is used as a preservative, it seems essential to neutralize the samples before analysis. This is particularly obvious with the chromatographic method used for analysis of citrate that was used in this study.
[Mh] MeSH terms primary: Specimen Handling/methods
Urolithiasis/urine
[Mh] MeSH terms secundary: Humans
Risk Assessment
Risk Factors
Urolithiasis/etiology
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Js] Journal subset:IM
[Da] Date of entry for processing:150127
[St] Status:MEDLINE

  2 / 5823 MEDLINE  
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[PMID]: 25832932
[Au] Autor:Zhang C; Ren H; Shen P; Xu Y; Zhang W; Wang W; Li X; Ma Y; Chen N
[Ad] Address:Department of Nephrology, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University, School of Medicine, China.
[Ti] Title:Clinical evaluation of chinese patients with primary distal renal tubular acidosis.
[So] Source:Intern Med;54(7):725-30, 2015.
[Is] ISSN:1349-7235
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Objective Distal renal tubular acidosis (dRTA) is a hyperchloremic metabolic acidosis disorder characterized by a normal anion gap with abnormal urinary hydrogen (H(+)) excretion. At present, there are few available reports regarding the clinical status of primary dRTA. The primary objective of this study was to analyze the clinical features and outcomes of primary dRTA. Methods This was a retrospective study performed in patients with primary dRTA who were hospitalized at Ruijin Hospital between March 1996 and July 2009; the clinical features of these patients were analyzed. Results This study included 95 consecutive inpatients: 40 men (42.11%) and 55 women (57.89%). Among them, 60 had hypokalemia (63.12%), 29 had complete dRTA and 66 had incomplete dRTA. The mean urine calcium levels of the patients with and without urinary lithiasis were 0.10±0.04 and 0.07±0.05 mmol/24 h・kg, respectively (p=0.04). The blood pH values of the patients with and those without bone disease were 7.37±0.06 and 7.32±0.06, respectively (p=0.01). A total of 8.33% (8/27) of the patients had tubular proteinuria. Conclusion Hypokalemia is the most common clinical manifestation of primary dRTA. Primary dRTA can also be accompanied by proximal tubular dysfunction. Controlling the urine calcium and citrate levels is crucial for the treatment of nephrocalcinosis and/or nephrolithiasis, while restoring the blood pH to the normal level is essential for controlling bone disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.2169/internalmedicine.54.9421

  3 / 5823 MEDLINE  
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[PMID]: 25523667
[Au] Autor:Assimos DG
[Ti] Title:Re: Predicting urinary stone composition based on single-energy noncontrast computed tomography: the challenge of cystine.
[So] Source:J Urol;193(1):170-1, 2015 Jan.
[Is] ISSN:1527-3792
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Calculi/chemistry
Calculi/radiography
Cystine/analysis
Tomography, X-Ray Computed/methods
Urolithiasis/radiography
[Mh] MeSH terms secundary: Female
Humans
Male
[Pt] Publication type:COMMENT; EDITORIAL
[Nm] Name of substance:48TCX9A1VT (Cystine)
[Em] Entry month:1504
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:141219
[St] Status:MEDLINE

  4 / 5823 MEDLINE  
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[PMID]: 25375751
[Au] Autor:Schiappacasse G; Aguirre J; Soffia P; Silva CS; Zilleruelo N
[Ad] Address:1 Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
[Ti] Title:CT findings of the main pathological conditions associated with horseshoe kidneys.
[So] Source:Br J Radiol;88(1045):20140456, 2015 Jan.
[Is] ISSN:1748-880X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Horseshoe kidney (HSK) is the most common renal fusion anomaly, with a prevalence of 0.25% among the general population. It consists of kidney fusion across the midline. HSK can be present as an isolated condition in 30%, but there is a wide variety of associated abnormalities. The most frequent include ureteropelvic obstruction, lithiasis and infections. There is also a higher risk of kidney lesions in trauma and an increased incidence of malignancies. Awareness of embryology and anatomy is essential to assess and understand the complications affecting HSK. CT is an excellent method for identification of its main findings.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 150113
[Lr] Last revision date:150113
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1259/bjr.20140456

  5 / 5823 MEDLINE  
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[PMID]: 25437581
[Au] Autor:Justo-Janeiro JM; Vincent GT; Vázquez de Lara F; de la Rosa Paredes R; Orozco EP; Vázquez de Lara LG
[Ad] Address:1 Department of Surgery, General Hospital of Puebla "Dr. Eduardo Vázquez Navarro," Puebla, Mexico.
[Ti] Title:One, two, or three ports in laparoscopic cholecystectomy?
[So] Source:Int Surg;99(6):739-44, 2014 Nov-Dec.
[Is] ISSN:0020-8868
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Abstract Single-port laparoscopic cholecystectomy (LC) has been compared with 3- or 4-port LC. To our knowledge, there are no studies comparing the 3-, 2-, and 1-port techniques. Patients were randomized into 3 groups: LC 1-port using SILS, LC 2-port using a laparoscope with a working channel, and LC 3-port using the standard ports. Pain was evaluated at recovery, 4 hours, 24 hours, day 5, and day 8, using an analog visual scale. Homogenous groups in their demographic characteristics; all confirmed gallbladder lithiasis. At recovery, there was less pain in group 1 (P = 0.002); at 4 hours pain was similar in all groups (P = 0.899); at 24 hours there was less pain in groups 2 and 3 (P = 0.031); and at days 5 and 8 there was marginal (P = 0.053) and significant (P = 0.003) relevance. In terms of pain perception, LC performed through 1 port does not offer advantages when compared with 2 or 3 ports. More clinical trials are needed to confirm these data.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 141206
[Lr] Last revision date:141206
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.9738/INTSURG-D-13-00234.1

  6 / 5823 MEDLINE  
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[PMID]: 25306481
[Au] Autor:de Cógáin MR; Lieske JC; Vrtiska TJ; Tosh PK; Krambeck AE
[Ad] Address:Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, MN....
[Ti] Title:Secondarily infected nonstruvite urolithiasis: a prospective evaluation.
[So] Source:Urology;84(6):1295-300, 2014 Dec.
[Is] ISSN:1527-9995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To characterize patients who form nonstruvite stones associated with infection (secondarily infected calculi), and to define the bacteria associated with these. MATERIALS AND METHODS: Patients undergoing percutaneous nephrolithotomy were prospectively recruited. Medical records were reviewed, and stones were analyzed using micro computed tomography and infrared spectroscopy. A fragment of each stone was sent for bacterial culture. Patients were categorized by stone culture results (SC ±) and the presence of struvite (ST ±). The Fisher exact test was used for comparison of proportion. Sterility of intraoperative SC was established with independently collected controls. RESULTS: In total, 125 patients were enrolled: 24 SC+/ST-, 19 SC+/ST+, and 82 SC-/ST-. Proportions of patients with prior urologic surgery, diabetes, and immunodeficiency were similar between groups. Patients with neurogenic bladder were more likely to have SC+/ST+ stones or SC+/ST- stones than SC-/ST- stones (26% vs 8% vs 0%, respectively; P <.01). Among patients with metabolic evaluations, hypocitraturia was found in 31.6% (6 of 19) SC+/ST- patients, 46.7% (7 of 15) SC+/ST+ patients, and 26.0% (19 of 73) of SC-/ST- patients (P = .28). Approximately 40% of cultured organisms in the secondarily infected calculi possessed urease and another 40% citrate lyase activities. CONCLUSION: Secondarily infected stones were detected in approximately 20% of this surgical cohort and may be more common than previously appreciated. Neurogenic bladder appeared to predispose patients to either struvite or secondarily infected stones. The role of bacterial infection in stone formation is unclear but may include alteration of urinary components, acting as a nidus for crystallization, or inducing inflammation.
[Mh] MeSH terms primary: Magnesium Compounds/chemistry
Nephrostomy, Percutaneous/adverse effects
Phosphates/chemistry
Urinary Tract Infections/microbiology
Urolithiasis/microbiology
Urolithiasis/surgery
[Mh] MeSH terms secundary: Adult
Aged
Calcium Oxalate/chemistry
Calcium Phosphates/chemistry
Cohort Studies
Female
Humans
Incidence
Male
Middle Aged
Nephrostomy, Percutaneous/methods
Postoperative Care
Preoperative Care
Prognosis
Prospective Studies
Risk Assessment
Uric Acid/chemistry
Urinalysis
Urinary Tract Infections/epidemiology
Urinary Tract Infections/etiology
Urinary Tract Infections/physiopathology
Urolithiasis/complications
Urolithiasis/diagnosis
[Pt] Publication type:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Calcium Phosphates); 0 (Magnesium Compounds); 0 (Phosphates); 15490-91-2 (struvite); 2612HC57YE (Calcium Oxalate); 268B43MJ25 (Uric Acid); 97Z1WI3NDX (calcium phosphate)
[Em] Entry month:1501
[Cu] Class update date: 150401
[Lr] Last revision date:150401
[Js] Journal subset:IM
[Da] Date of entry for processing:141129
[St] Status:MEDLINE

  7 / 5823 MEDLINE  
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[PMID]: 25406395
[Au] Autor:Garcia TX; Farmaha JK; Kow S; Hofmann MC
[Ad] Address:Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Unit 1105, PO Box 301402, Houston, TX 77230-1402, USA Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA....
[Ti] Title:RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche.
[So] Source:Development;141(23):4468-78, 2014 Dec.
[Is] ISSN:1477-9129
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Stem cells are influenced by their surrounding microenvironment, or niche. In the testis, Sertoli cells are the key niche cells directing the population size and differentiation fate of spermatogonial stem cells (SSCs). Failure to properly regulate SSCs leads to infertility or germ cell hyperplasia. Several Sertoli cell-expressed genes, such as Gdnf and Cyp26b1, have been identified as being indispensable for the proper maintenance of SSCs in their niche, but the pathways that modulate their expression have not been identified. Although we have recently found that constitutively activating NOTCH signaling in Sertoli cells leads to premature differentiation of all prospermatogonia and sterility, suggesting that there is a crucial role for this pathway in the testis stem cell niche, a true physiological function of NOTCH signaling in Sertoli cells has not been demonstrated. To this end, we conditionally ablated recombination signal binding protein for immunoglobulin kappa J region (Rbpj), a crucial mediator of NOTCH signaling, in Sertoli cells using Amh-cre. Rbpj knockout mice had: significantly increased testis sizes; increased expression of niche factors, such as Gdnf and Cyp26b1; significant increases in the number of pre- and post-meiotic germ cells, including SSCs; and, in a significant proportion of mice, testicular failure and atrophy with tubule lithiasis, possibly due to these unsustainable increases in the number of germ cells. We also identified germ cells as the NOTCH ligand-expressing cells. We conclude that NOTCH signaling in Sertoli cells is required for proper regulation of the testis stem cell niche and is a potential feedback mechanism, based on germ cell input, that governs the expression of factors that control SSC proliferation and differentiation.
[Mh] MeSH terms primary: Cellular Microenvironment/physiology
Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism
Sertoli Cells/metabolism
Spermatogonia/physiology
Stem Cells/physiology
Testis/cytology
Testis/embryology
[Mh] MeSH terms secundary: Animals
Gene Expression Regulation, Developmental/physiology
Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics
Immunohistochemistry
Male
Mice
Mice, Knockout
Real-Time Polymerase Chain Reaction
Receptors, Notch/metabolism
Signal Transduction/physiology
Testis/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Immunoglobulin J Recombination Signal Sequence-Binding Protein); 0 (Rbpj protein, mouse); 0 (Receptors, Notch)
[Em] Entry month:1501
[Cu] Class update date: 150401
[Lr] Last revision date:150401
[Js] Journal subset:IM
[Da] Date of entry for processing:141121
[St] Status:MEDLINE
[do] DOI:10.1242/dev.113969

  8 / 5823 MEDLINE  
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[PMID]: 25058778
[Au] Autor:Sanada Y; Yamada N; Taguchi M; Morishima K; Kasahara N; Kaneda Y; Miki A; Ishiguro Y; Kurogochi A; Endo K; Koizumi M; Sasanuma H; Fujiwara T; Sakuma Y; Shimizu A; Hyodo M; Sata N; Yasuda Y
[Ad] Address:1 Department of Surgery, Jichi Medical University, Shimotsuke, Japan.
[Ti] Title:Recurrent cholangitis by biliary stasis due to non-obstructive afferent loop syndrome after pylorus-preserving pancreatoduodenectomy: report of a case.
[So] Source:Int Surg;99(4):426-31, 2014 Jul-Aug.
[Is] ISSN:0020-8868
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Abstract We report a 71-year-old man who had undergone pylorus-preserving pancreatoduodenectomy (PPPD) using PPPD-IV reconstruction for cholangiocarcinoma. For 6 years thereafter, he had suffered recurrent cholangitis, and also a right liver abscess (S5/8), which required percutaneous drainage at 9 years after PPPD. At 16 years after PPPD, he had been admitted to the other hospital because of acute purulent cholangitis. Although medical treatment resolved the cholangitis, the patient was referred to our hospital because of dilatation of the intrahepatic biliary duct (B2). Peroral double-balloon enteroscopy revealed that the diameter of the hepaticojejunostomy anastomosis was 12 mm, and cholangiography detected intrahepatic stones. Lithotripsy was performed using a basket catheter. At 1 year after lithotripsy procedure, the patient is doing well. Hepatobiliary scintigraphy at 60 minutes after intravenous injection demonstrated that deposit of the tracer still remained in the upper afferent loop jejunum. Therefore, we considered that the recurrent cholangitis, liver abscess, and intrahepatic lithiasis have been caused by biliary stasis due to nonobstructive afferent loop syndrome. Biliary retention due to nonobstructive afferent loop syndrome may cause recurrent cholangitis or liver abscess after hepaticojejunostomy, and double-balloon enteroscopy and hepatobiliary scintigraphy are useful for the diagnosis of nonobstructive afferent loop syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.9738/INTSURG-D-13-00243.1

  9 / 5823 MEDLINE  
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[PMID]: 24637469
[Au] Autor:Bourdoumis A; Miernik A; Hawizy A; Kachrilas S; El Howairis M; Schoenthaler M; Masood J; Buchholz N
[Ad] Address:Department of Urology Endourology and Stone Services, Royal London Hospital Barts Health NHS Trust, London, UK - bourdoua@hotmail.com.
[Ti] Title:A comprehensive update on urinary tract lithiasis management.
[So] Source:Panminerva Med;56(1):1-15, 2014 Mar.
[Is] ISSN:1827-1898
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:In the past decade, the field of urology has been one of the most rapidly progressing in applied technological advancements at the level of both medical diagnostics and treatment. The introduction of modern robotic laparoscopy has changed the face of minimally invasive surgery. For endourology specialists, stone surgery continues to be in the forefront of daily practice and innovations and new technologies are constantly being developed, aiming towards ever higher stone free rates and earlier recovery for the patient. But, is there a price? Indeed, in addition to advances in conservative treatment and prevention, modern endourology and stone disease management in particular enjoys a large variety of sophisticated new equipment and disposables, used either alone or in combination, developed from various companies at considerable cost. It is more than often that even expert professionals are not totally familiar with the whole range of treatment options and devices that are available in the market, as they commonly bear different names despite being used for the same purpose. Furthermore, a question of integrity might arise when using newly developed equipment directly in the operating theatre, with respect to the efficacy of the device as well as the learning curve required by the operator. In this review, we shall outline the latest advances in interventional lithotripsy technology and also demonstrate the most effective ways to use each particular modality efficiently and safely, with respect to the latest published guidelines and evidence-based recommendations.
[Mh] MeSH terms primary: Lithotripsy/methods
Ureteroscopy/methods
Urinary Tract/pathology
Urolithiasis/therapy
Urology/trends
[Mh] MeSH terms secundary: History, 20th Century
History, 21st Century
Humans
Urology/history
Urology/methods
[Pt] Publication type:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1504
[Js] Journal subset:IM
[Da] Date of entry for processing:140318
[St] Status:MEDLINE

  10 / 5823 MEDLINE  
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[PMID]: 23917151
[Au] Autor:Neri V; Ambrosi A; Fersini A; Tartaglia N; Lapolla F
[Ti] Title:Common bile duct lithiasis: therapeutic approach.
[So] Source:Ann Ital Chir;84(4):405-10, 2013 Jul-Aug.
[Is] ISSN:2239-253X
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Treatment of cholecysto-choledocholithiasis has been revisited from the standpoint of either endoscopic or laparoscopic mini invasive approach. A standard diagnostic-therapeutic procedure has not been unanimously defined. PATIENTS AND METHODS: Since 1997 to 2011 we have treated 924 patients: 555 gallbladder lithiasis, 276 acute biliary pancreatitis and 93 choledocholithiasis (without pancreatitis). We have compared, by the review of the literature, our results of two stage endoscopic stones removal followed by laparoscopic cholecystectomy versus one stage laparo-endoscopic rendezvous technique/VLC and laparoscopic approach alone. RESULTS: In our experience endoscopic removal of stones have been performed in 82 patients (88.17%); 11 patients (11.82%),not eligible for endoscopic approach, have been submitted to laparotomic therapy. In sum preoperative ERCP/ES with CBD cleaning followed by VLC, not with standing the valid results of laparoscopic approach alone remains the strategy more frequently applied in clinical practice, because the good results. CONCLUSIONS: The results of the treatment of CBD lithiasis of sequential laparo-endoscopic approach (two or one stage) and of laparoscopic approach alone are roughly overlappable. Therefore the first has remained the treatment of reference and comparison in all the clinical evaluation of different procedure.
[Mh] MeSH terms primary: Choledocholithiasis/surgery
[Mh] MeSH terms secundary: Choledocholithiasis/complications
Endoscopy
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1504
[Js] Journal subset:IM
[Da] Date of entry for processing:130806
[St] Status:MEDLINE


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