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[PMID]: 27795771
[Au] Autor:Badji N; Akpo G; Deme H; Toure MH; Ly M; Ndong B; Niang EH
[Ad] Address:Service de Radiologie Générale du CHU Aristide Le Dantec, Dakar, Sénégal.
[Ti] Title:Place de la bili-IRM dans le diagnostic etiologique des icteres cholestatiques à Dakar. [Role of biliary MRI in etiological diagnosis of cholestatic icteruses in Dakar].
[So] Source:Pan Afr Med J;24:174, 2016.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:FRE
[Ab] Abstract:Biliary MRI is a relatively new diagnostic test in the arsenal of exploration techniques in biliopancreatic pathology. This is a reproducible and reliable non invasive technique for direct visualization of biliary and pancreatic ducts. This study aims to evaluate the morphological features of major abnormalities and the role of biliary MRI in the etiological diagnosis of cholestatic icteruses. This is a retrospective study of 17 patients conducted in the Imaging Unit of the University Hospital of Fann and of the Principal hospital of Dakar over a period of 4 years and six months (January 2008 at July 2012). All patients underwent MRI (1.5T) according to the standardized protocols for the explored pathology. Only medical records of patients whose diagnosis was established based on laboratory tests and who underwent biliary MRI and surgical exploration were retained. The study involved 5 women and 12 men with a sex ratio of 2.4. The average age of patients was 58 years, ranging between 35 and 81 years. Klatskin tumors were found in 7 patients with infiltrative form in 71% of cases and exophytic form was found in 28% of cases. Cancers of the gallbladder were found in 28% of cases. Cancers in the head of the pancreas accounted for 28% of cases. Major bile duct lithiasis was detected in 5 patients, choledocholithiasis in 60% of cases and a single lithiasis in 40% of cases. All these lesions were responsible for an expansion of intrahepatic bile duct (IHBD). One case of intra and extrahepatic bile ducts dilatation was found without biliopancreatic cause. Biliary MRI is the test of choice for the exploration of cholestatic icteruses. It should be recommended as first-line examination when residual lithiasis is suspected and as second-line examination after ultrasound, when the latter shows a suspected bile ducts tumoral obstruction. Its association with CT scan is the best combination of screening tests for etiologic diagnosis and pre-operative assessment of tumoral biliary obstructions.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  2 / 6262 MEDLINE  
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[PMID]: 27793365
[Au] Autor:Pieras E; Tubau V; Brugarolas X; Ferrutxe J; Pizá P
[Ad] Address:Servicio de Urología, Hospital universitario Son Espases, Palma de Mallorca, España. Electronic address: enriquec.pieras@ssib.es.
[Ti] Title:Análisis comparativo entre nefrolitotomía percutánea y ureteroscopia flexible en litiasis renal de 2-3cm. Comparative analysis between percutaneous nephrolithotomy and flexible ureteroscopy in kidney stones of 2-3cm.
[So] Source:Actas Urol Esp;, 2016 Oct 25.
[Is] ISSN:1699-7980
[Cp] Country of publication:Spain
[La] Language:ENG; SPA
[Ab] Abstract:INTRODUCTION: To compare percutaneous nephrolithotomy and flexible ureterorenoscopy for treating kidney stones between 2 and 3cm. MATERIAL AND METHODS: A prospective, comparative, nonrandomised study was conducted with 108 patients with kidney stones between 2 and 3cm. Fifty-four patients underwent percutaneous nephrolithotomy and 54 underwent flexible ureteroscopy. We compared the following variables: lithiasis-free rate (%), surgical time, the need for an auxiliary process, postoperative complications, hospital stay, readmission rates and recovery time. RESULTS: There were no differences in the lithiasis-free rate between the 2 surgical techniques (76% for ureteroscopy vs. 87% for nephrolithotomy; P=.1) or in the complications (29% for nephrolithotomy vs. 27% for ureteroscopy; P=.4). A larger number of auxiliary process were needed for the ureteroscopy group (20%) than for the nephrolithotomy group (7%) (P=.04). The surgical time was longer for the nephrolithotomy group (121±52min) than for the ureteroscopy group (93±42min) (P=.004). The ureteroscopy group had shorter hospital stays (2.1±1.6 vs. 3.9±1.9 days; P=.002), shorter convalescence (8.1±4.9 vs. 13.3±4.2 days; P=.005) and higher readmission rates (7.4% vs. 0%, P=.05) than the nephrolithotomy group. CONCLUSIONS: Nephrolithotomy and ureteroscopy have similar efficacy for treating kidney stones measuring 2-3cm, with no differences in complications. Ureteroscopy results in shorter hospital stays, quicker recoveries but more readmissions and a greater need for auxiliary procedures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:Publisher

  3 / 6262 MEDLINE  
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[PMID]: 27793122
[Au] Autor:Fontana F; Cappelli G
[Ad] Address:Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy. francesco.fontana@unimore.it.
[Ti] Title:Acute pancreatitis associated with everolimus after kidney transplantation: a case report.
[So] Source:BMC Nephrol;17(1):163, 2016 Oct 28.
[Is] ISSN:1471-2369
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Acute pancreatitis (AP) following KT is a rare and often fatal complication of the early post-transplant period. Common causative factors for AP are rare after KT; anti-rejection drugs as CyA, prednisone and MMF have been implicated, although evidence is not strong and we found no reports on possible causative role for mTOR inhibitors. CASE PRESENTATION: A 55-year-old Caucasian man with end-stage renal disease due to idiopathic membrano-prolipherative glomerulonephritis underwent single kidney transplantation (KT) from cadaveric donor. Anti-rejection protocol was based on Basiliximab induction followed by prednisone and mycophenolate mophetil (MMF) and Cyclosporine; Everolimus (Eve) was scheduled to substitute MMF at week 3. At day 1 he had an asymptomatic elevation of pancreatic enzymes, spontaneously resolved. The further course was unremarkable and on day 19 he started Eve, with following asymptomatic rise in pancreatic enzymes. At day 33 the patient presented with abdominal pain and a marked elevation in serum amylase (1383 U/l) and lipase (1015 U/l), normal liver enzymes and bilirubin, no hypercalcemia, mild elevation in triglycerids; RT-PCRs for Cytomegalovirus or Epstein-Barr virus were negative. The patient had no history of alcohol abuse; ultrasound, CT and MRI found no evidence of biliary lithiasis. CT scans showed a patchy fluid collection in the pancreatic head area, consistent with idiopathic necrotizing pancreatitis. The patient was treated medically and Eve was withdrawn 1 week after. Patient underwent guided drainage of the fluid collection, but developed bacterial sepsis; surgical intervention was required with debridement of necrotic tissue, lavage and drainage; immunosuppression was totally withdrawn. Following course was complicated with multiple systemic infection. Transplantectomy for acute rejection was performed, and patient entered hemodialysis. CONCLUSIONS: Our patient had a presentation that is consistent for a causative role of Eve. A predisposing condition (acute pancreatic insult during transplant surgery) spontaneously resolved, relapsed and evolved rapidly in AP after the initiation of treatment with Eve with a consistent time latency. None of the well-known common causative factors for AP was present. We discourage the use of Eve in patients with recent episodes of sub-clinical pancreatitis, since it may represent a precipitating factor or interfere with resolution.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  4 / 6262 MEDLINE  
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[PMID]: 27790013
[Au] Autor:Ea HK; Richette P
[Ad] Address:Hôpital Lariboisière, Rheumatology Department, Paris, France; University of Paris Diderot, Sorbonne Paris Cité, Paris, France.
[Ti] Title:Critical appraisal of the role of pegloticase in the management of gout.
[So] Source:Open Access Rheumatol;4:63-70, 2012.
[Cp] Country of publication:New Zealand
[La] Language:ENG
[Ab] Abstract:Gout is a debilitating disease secondary to chronic hyperuricemia, and the subsequent deposition of monosodium urate crystals is responsible for acute flare, gout arthropathies, tophi and renal lithiasis. Uric acid is the end product of purine metabolism in humans because the gene encoding uricase was lost during hominoid evolution. Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol that catalyzes the oxidation of uric acid into allantoin, a more soluble end product. The use of this drug as urate-lowering therapy is a new approach in treating severe gout refractory to conventional therapy with xanthine oxidase inhibitors and uricosuric agents. Intravenous pegloticase has potent and long-lasting urate-lowering capacity with rapid efficacy on tophi resolution. However, pegloticase treatment is associated with infusion-related reactions despite prevention therapy with high-dose corticosteroids. Exacerbation of pre-existing cardiovascular diseases is another concern. The mechanisms of these events are unknown. Caution with long-term use of pegloticase is warranted, especially for patients with cardiovascular diseases.
[Pt] Publication type:REVIEW; JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  5 / 6262 MEDLINE  
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[PMID]: 26753318
[Au] Autor:Brandenberger-Schenk F; Rothenanger E; Reusch CE; Gerber B
[Ti] Title:Urolithen von Hunden in der Schweiz von 2003 bis 2009. [Uroliths of dogs in Switzerland from 2003 to 2009].
[So] Source:Schweiz Arch Tierheilkd;157(1):41-8, 2015 Jan.
[Is] ISSN:0036-7281
[Cp] Country of publication:Switzerland
[La] Language:GER
[Ab] Abstract:Information on composition of uroliths collected between 2003 and 2009 from dogs in Switzerland and epidemiologic data of affected dogs are summarised in this paper. Of 490 stones analysed 44% were composed of calcium oxalate, 330% of struvite, 80% of silica, 7% of urate, 3% of cystine, 3% were mixed stones and 1% each were calcium phosphate and xanthine stones. Compared to other dogs, Norwich Terriers, Norfolk Terriers, Miniature Schnauzers, Miniature Pinscher and Yorkshire Terriers had a significantly increased risk to suffer from calcium oxalate stones, Dalmatians and Continental Bulldogs from urate stones and English Bulldogs from cystine stones. No breed had an increased risk of struvite or silica stones. Stones composed of silica were more prevalent in Switzerland compared to other countries and were more common in the eastern part than in the western part of Switzerland. This study shows that there are differences in occurrence and prevalence of uroliths between Switzerland and surveys of other countries.
[Mh] MeSH terms primary: Dog Diseases/epidemiology
Urinary Calculi/veterinary
Urolithiasis/veterinary
[Mh] MeSH terms secundary: Animals
Breeding
Calcium Oxalate/analysis
Calcium Phosphates/analysis
Cystine/analysis
Dogs
Female
Magnesium Compounds/analysis
Male
Phosphates/analysis
Prevalence
Risk Factors
Silicon Dioxide/analysis
Switzerland/epidemiology
Uric Acid/analysis
Urinary Calculi/chemistry
Urolithiasis/epidemiology
Xanthine/analysis
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Calcium Phosphates); 0 (Magnesium Compounds); 0 (Phosphates); 1AVZ07U9S7 (Xanthine); 2612HC57YE (Calcium Oxalate); 268B43MJ25 (Uric Acid); 48TCX9A1VT (Cystine); 7631-86-9 (Silicon Dioxide); 97Z1WI3NDX (calcium phosphate); AW3EJL1462 (struvite)
[Em] Entry month:1602
[Cu] Class update date: 161026
[Lr] Last revision date:161026
[Js] Journal subset:IM
[Da] Date of entry for processing:016112
[St] Status:MEDLINE

  6 / 6262 MEDLINE  
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[PMID]: 27775283
[Au] Autor:Fernández Ibieta M; Bujons Tur A; Caffaratti Sfulcini J; Alberola J; Bonín D; Jiménez Corro R; Villavicencio H
[Ad] Address:Servicio de Cirugía Pediátrica. Hospital CU Virgen de la Arrixaca. Murcia.
[Ti] Title:Litotricia extracorpórea en pacientes pediátricos. [Pediatric Extracorporeal Shock Wave Lithotripsy].
[So] Source:Cir Pediatr;28(2):59-66, 2016 Jan 15.
[Is] ISSN:0214-1221
[Cp] Country of publication:Spain
[La] Language:SPA
[Ab] Abstract:INTRODUCTION: Extracorporeal Shock Wave lithotripsy (ESWL) is the cornerstone of pediatric urolitiasis management. We evaluated its efficacy and complications in a series of children. MATERIAL AND METHODS: Children who were managed with ESWL between 2003 and 2012 were retrospectively reviewed. We studied etiology, clinical presentation, stonefree ratio and relevant complications. SPSS 17.0 software was used. RESULTS: 90 children aged 0 to 10 years (median 2.9 years) were included in the study; that accounted for 122 stones and 162 ESWL sessions. Mean follow up was 20 months. Mean stone diameter was 12.2 mm. (range 4-25). Most prevalent clinical sign was urinary infection (55.6%, 50 patients). 75.4% of the lithiasis were found in renal pelvis or calices. A mean of 1.42 ESWL sessions per stone was performed. Stonefree status was reached in 80.3% (98) of the lithiasis. This rate was higher in patients below 5 years of age (86.1% vs., 69.8%, p=0.03), and worse in staghorn calculi (66% vs. 87.2%) and cystine ones (30% vs. 84.8%, p<0.001). We observed 17 complications (10.4% among 162 sessions), 6 UTIs, 6 episodes of fever and 6 episodes of UTI associated with steinstrasse. Almost all complications were associated with bigger size, staghorn calculi and struvite. DISCUSSION: Best results are found in younger patients and small calculi. ESWL is a safe and efficient procedure in pediatric patients.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161025
[Lr] Last revision date:161025
[St] Status:In-Data-Review

  7 / 6262 MEDLINE  
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[PMID]: 26665781
[Ti] Title:[Aleksey Mikhailovich Voyno-Yasenetsky].
[So] Source:Urologiia;(4):134-5, 2015 Jul-Aug.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:RUS
[Mh] MeSH terms primary: Urolithiasis/history
Urologic Surgical Procedures/history
Urology/history
[Mh] MeSH terms secundary: History, 20th Century
History, 21st Century
Humans
Portraits as Topic
[Pt] Publication type:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Personal name as subject:Voyno-Yasenetsky AM
[Em] Entry month:1512
[Cu] Class update date: 151214
[Lr] Last revision date:151214
[Js] Journal subset:IM
[Da] Date of entry for processing:151214
[St] Status:MEDLINE

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[PMID]: 26401845
[Au] Autor:Becknell B; Mohamed AZ; Li B; Wilhide ME; Ingraham SE
[Ad] Address:Nephrology Section, Nationwide Children's Hospital, Columbus, OH, United States of America; Department of Pediatrics, Ohio State University School of Medicine, Columbus, OH, United States of America; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's, Col
[Ti] Title:Urine Stasis Predisposes to Urinary Tract Infection by an Opportunistic Uropathogen in the Megabladder (Mgb) Mouse.
[So] Source:PLoS One;10(9):e0139077, 2015.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:PURPOSE: Urinary stasis is a risk factor for recurrent urinary tract infection (UTI). Homozygous mutant Megabladder (Mgb-/-) mice exhibit incomplete bladder emptying as a consequence of congenital detrusor aplasia. We hypothesize that this predisposes Mgb-/- mice to spontaneous and experimental UTI. METHODS: Mgb-/-, Mgb+/-, and wild-type female mice underwent serial ultrasound and urine cultures at 4, 6, and 8 weeks to detect spontaneous UTI. Urine bacterial isolates were analyzed by Gram stain and speciated. Bladder stones were analyzed by x-ray diffractometry. Bladders and kidneys were subject to histologic analysis. The pathogenicity of coagulase-negative Staphylococcus (CONS) isolated from Mgb-/- urine was tested by transurethral administration to culture-negative Mgb-/- or wild-type animals. The contribution of urinary stasis to CONS susceptibility was evaluated by cutaneous vesicostomy in Mgb-/- mice. RESULTS: Mgb-/- mice develop spontaneous bacteriuria (42%) and struvite bladder stones (31%) by 8 weeks, findings absent in Mgb+/- and wild-type controls. CONS was cultured as a solitary isolate from Mgb-/- bladder stones. Bladders and kidneys from mice with struvite stones exhibit mucosal injury, inflammation, and fibrosis. These pathologic features of cystitis and pyelonephritis are replicated by transurethral inoculation of CONS in culture-negative Mgb-/- females, whereas wild-type animals are less susceptible to CONS colonization and organ injury. Cutaneous vesicostomy prior to CONS inoculation significantly reduces the quantity of CONS recovered from Mgb-/- urine, bladders, and kidneys. CONCLUSIONS: CONS is an opportunistic uropathogen in the setting of urinary stasis, leading to enhanced UTI incidence and severity in Mgb-/- mice.
[Mh] MeSH terms primary: Staphylococcus/physiology
Urinary Tract Infections/etiology
Urinary Tract Infections/microbiology
Urolithiasis/complications
[Mh] MeSH terms secundary: Animals
Bacteriuria/complications
Bacteriuria/microbiology
Cystitis/complications
Disease Susceptibility
Female
Hydrogen-Ion Concentration
Magnesium Compounds
Mice
Mice, Mutant Strains
Phosphates
Pyelonephritis/complications
Urinary Bladder/pathology
Urinary Diversion
Urinary Tract/microbiology
Urinary Tract/pathology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Magnesium Compounds); 0 (Phosphates); AW3EJL1462 (struvite)
[Em] Entry month:1606
[Cu] Class update date: 161025
[Lr] Last revision date:161025
[Js] Journal subset:IM
[Da] Date of entry for processing:015925
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0139077

  9 / 6262 MEDLINE  
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[PMID]: 27403774
[Au] Autor:Eroglu N; Erduran E; Imamoglu M; Sagnak Z; Cansu A
[Ad] Address:Departments of *Pediatric Hematology and Oncology †Pediatric Surgery ‡Pathology §Radiogical, Karadeniz Technical University, Trabzon, Turkey.
[Ti] Title:Diffuse Adenomyomatosis of the Gallbladder in a Child.
[So] Source:J Pediatr Hematol Oncol;38(8):e307-e309, 2016 Nov.
[Is] ISSN:1536-3678
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:Adenomyomatosis of the gallbladder (ADMG) is characterized by proliferation of the mucosal epithelium and hypertrophy of the muscularis. ADMG is predominantly diagnosed by using ultrasonography. Although ADMG is benign in nature, lithiasis, and chronic inflammation secondary to it may lead to dysplastic changes and cancer. Mucosal invagination through the hypertrophied muscularis results in large intramural diverticula or sinus tracts which are visible at radiology, known as Rokitansky-Aschoff sinuses. Histologically, ADMG manifests with hyperplasia of the muscular layer and proliferation of mucosal glandular tissues. We describe a case of ADMG in an 8-year-old girl presenting with recurrent abdominal pain. Diagnosis was made using ultrasound, and the condition was successfully treated with open cholecystectomy. Ultrasound scanning in children presenting with recurrent abdominal pain may lead to more accurate diagnosis of ADMG during childhood.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:0167
[Cu] Class update date: 161022
[Lr] Last revision date:161022
[St] Status:In-Data-Review

  10 / 6262 MEDLINE  
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[PMID]: 26667826
[Au] Autor:Kok DJ
[Ad] Address:Department of Urology, Erasmus MC, Rotterdam, The Netherlands. d.kok@erasmusmc.nl.
[Ti] Title:The preventive treatment of recurrent stone-formation: how can we improve compliance in the treatment of patients with recurrent stone disease?
[So] Source:Urolithiasis;44(1):83-90, 2016 Feb.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:ENG
[Ab] Abstract:Whether prevention of Urolithiasis is worthwhile is the outcome of the balance between efficacy of prevention and costs and efforts related of respectively prevention and treatment of a new stone. Well controlled trials demonstrate that effective prevention of new stone formation is possible using medical treatment and lifestyle interventions. In long-term general practice the results obtained with preventive interventions is disappointing. Low and diminishing long-term compliance to the intervention is a major cause for this. Both the long-term aspect and the natural resistance to lifestyle changes contribute to this low compliance. From an analysis of the existing data on trials of preventive interventions and from experiences obtained in other patient groups where lifestyle changes are applied I will make the case that self-empowerment of the patient using m-health lifestyle coaching (a smart phone application) can considerably enhance the level of prevention that is obtained in general practice. In conclusion, I will describe what features will improve usage and efficacy of such an app.
[Mh] MeSH terms primary: Patient Compliance
Urolithiasis/prevention & control
[Mh] MeSH terms secundary: Humans
Recurrence
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1610
[Cu] Class update date: 161022
[Lr] Last revision date:161022
[Js] Journal subset:IM
[Da] Date of entry for processing:016125
[St] Status:MEDLINE
[do] DOI:10.1007/s00240-015-0842-9


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