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| [PMID]: | 23375914 | | [Au] Autor: | Arrabal-Polo MA; Arias-Santiago S; de Haro-Muñoz T; Lopez-Ruiz A; Orgaz-Molina J; Gonzalez-Torres S; Zuluaga-Gomez A; Arrabal-Martin M |
| [Ad] Address: | Department of Urology, San Cecilio University Hospital, Granada, Spain. arrabalp@ono.com | | [Ti] Title: | Effects of aminobisphosphonates and thiazides in patients with osteopenia/osteoporosis, hypercalciuria, and recurring renal calcium lithiasis. | | [So] Source: | Urology;81(4):731-7, 2013 Apr. | | [Is] ISSN: | 1527-9995 | | [Cp] Country of publication: | United States | | [La] Language: | eng | | [Ab] Abstract: | OBJECTIVE: To analyze the effects of aminobisphosphonates and thiazides on renal lithogenic activity and bone mineral density in patients with recurring renal calcium lithiasis. MATERIALS AND METHODS: A prospective cohort study with 3 years of clinical follow-up data was performed. The study included 2 groups of patients with recurring calcium lithiasis, hypercalciuria, and bone mineral density loss. Group 1 included 35 patients who underwent treatment with 70 mg/wk alendronate. Group 2 included 35 patients who underwent treatment with 50 mg/d hydrochlothiazide and 70 mg/wk alendronate. Biochemical analysis was performed at baseline, 6 months, and 2 years, bone densitometry at baseline and 2 years, and clinical follow-up during the 3 years of treatment. The biochemical variables from the blood and urine samples, recurrent lithiasis, and bone mineral density were analyzed. RESULTS: Age, sex, baseline biochemical markers, and bone density showed no differences between the 2 treatment groups at the onset of treatment. After 2 years of treatment, group 1 showed a significant decrease in bone turnover markers and calciuria and significant improvement in bone mineral density. After 2 years of treatment, group 2 showed a decrease in calciuria and bone markers. At 2 years, the decrease in calciuria and the improvement in bone mineral density were greater in group 2 than in group 1, and the difference was statistically significant. CONCLUSION: Aminobisphosphonates improve bone mineral density and slow lithogenic activity; however, administration of aminobisphosphonates in association with thiazides produced the same clinical effects and also reduced calciuria and improved bone mineral density. | | [Pt] Publication type: | JOURNAL ARTICLE | | [Em] Entry month: | 1303 | | [Js] Journal subset: | IM | | [St] Status: | In-Process |
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