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[PMID]: 25170197
[Au] Autor:Boraschi P; Donati F
[Ad] Address:Piero Boraschi, Francescamaria Donati, 2 Unit of Radiology, Department of Diagnostic Radiology, Vascular and Interventional Radiology, and Nuclear Medicine, Pisa University Hospital, 56124 Pisa, Italy.
[Ti] Title:Postoperative biliary adverse events following orthotopic liver transplantation: assessment with magnetic resonance cholangiography.
[So] Source:World J Gastroenterol;20(32):11080-94, 2014 Aug 28.
[Is] ISSN:2219-2840
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Biliary adverse events following orthotopic liver transplantation (OLT) are relatively common and continue to be serious causes of morbidity, mortality, and transplant dysfunction or failure. The development of these adverse events is heavily influenced by the type of anastomosis during surgery. The low specificity of clinical and biologic findings makes the diagnosis challenging. Moreover, direct cholangiographic procedures such as endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography present an inadmissible rate of adverse events to be utilized in clinically low suspected patients. Magnetic resonance (MR) maging with MR cholangiopancreatography is crucial in assessing abnormalities in the biliary system after liver surgery, including liver transplant. MR cholangiopancreatography is a safe, rapid, non-invasive, and effective diagnostic procedure for the evaluation of biliary adverse events after liver transplantation, since it plays an increasingly important role in the diagnosis and management of these events. On the basis of a recent systematic review of the literature the summary estimates of sensitivity and specificity of MR cholangiopancreatography for diagnosis of biliary adverse events following OLT were 0.95 and 0.92, respectively. It can provide a non-invasive method of imaging surgical reconstruction of the biliary anastomoses as well as adverse events including anastomotic and non-anastomotic strictures, biliary lithiasis and sphincter of Oddi dysfunction in liver transplant recipients. Nevertheless, conventional T2-weighted MR cholangiography can be implemented with T1-weighted contrast-enhanced MR cholangiography using hepatobiliary contrast agents (in particular using Gd-EOB-DTPA) in order to improve the diagnostic accuracy in the adverse events' detection such as bile leakage and strictures, especially in selected patients with biliary-enteric anastomosis.
[Mh] MeSH terms primary: Bile Ducts/pathology
Biliary Tract Diseases/diagnosis
Cholangiopancreatography, Magnetic Resonance
Liver Transplantation/adverse effects
[Mh] MeSH terms secundary: Anastomotic Leak/diagnosis
Anastomotic Leak/etiology
Bile Ducts/injuries
Biliary Tract Diseases/etiology
Biliary Tract Diseases/pathology
Cholelithiasis/diagnosis
Cholelithiasis/etiology
Cholestasis/diagnosis
Cholestasis/etiology
Constriction, Pathologic
Humans
Predictive Value of Tests
Sphincter of Oddi Dysfunction/diagnosis
Sphincter of Oddi Dysfunction/etiology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140829
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v20.i32.11080

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[PMID]: 25970963
[Au] Autor:Ionescu L; Timofte D; Savin M; Fotea V; Danila R
[Ti] Title:Life-threatening complications of impacted common bile duct lithiasis. A case report.
[So] Source:Rev Med Chir Soc Med Nat Iasi;119(1):175-8, 2015 Jan-Mar.
[Is] ISSN:0048-7848
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:Impacted common bile duct (CBD) lithiasis poses therapeutical challenges and repeated attempts of removal may result in life-threatening complications. CASE REPORT. A 45 year-old female patient was admitted in emergency for right upper quadrant abdominal pain and jaundice. Clinical, lab data, abdominal ultrasound (US) and cholangio-MRI established the diagnosis of acute cholecystitis and obstructive jaundice due to distal CBD lithiasis. Endoscopic retrograde colangiopancreatography (ERCP) confirmed the presence of a distal CBD stone but extraction failed. The patient was operated on and surgical procedure consisted of cholecistectomy, intraoperative cholangiography and a side-to-side choledocho-duodenal anastomosis was performed because all attempts to extract the stone through choledocotomy or duodenotomy and enlargement of endoscopic shincterotomy failed. The postoperative course was endangered by a severe pancreatitis, a massive upper digestive bleeding and portal vein thrombosis that responded to conservative management in the intensive care unit. The patient was discharged after 34 days in good clinical condition and approximately 9 months later was readmitted electively for an incisional hernia. Apart from this, physical examination, lab tests and imagistic studies were normal; the patient was operated and rapidly discharged in good condition. In conclusion, the management of CBD lithiasis may be a serious challenge both for interventional endoscopists and surgeons and require a concerted team effort.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Process

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[PMID]: 24906454
[Au] Autor:Korkmaz M; Aras B; Sanal B; Yücel M; Güneyli S; Koçak A; Uruç F
[Ad] Address:Department of Radiology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey, drmehmetkorkmaz@gmail.com.
[Ti] Title:Investigating the clinical significance of twinkling artifacts in patients with urolithiasis smaller than 5 mm.
[So] Source:Jpn J Radiol;32(8):482-6, 2014 Aug.
[Is] ISSN:1867-108X
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:PURPOSE: Our aim was to evaluate the effectiveness of twinkling artifacts (TA) in detecting calculi <5 mm in diameter in patients with renal colic pain who had undergone urinary grayscale ultrasonography (US) and computed tomography (CT) imaging assays. MATERIALS AND METHODS: In this retrospective study, a total of 76 calculi <5 mm detected in 60 patients were evaluated. Whole data were established using an ultrasound (US) probe at frequencies 1.5-4.5 MHz and noncontrast CT. In US, echogenicity and posterior-shadow (PS) parameters were evaluated and compared with color-Doppler ultrasonography (CDUS) and CT signs. RESULTS: The mean size of measured calculi was 3.9 ± 0.8 mm (range 2-5 mm). The calculus localization rates detected by CT imaging were as follows: kidneys (n = 61, 80.3 %), proximal ureter (n = 4, 5.3 %), middle ureter (n = 3, 3.9 %) and distal ureter (n = 8, 10.5 %). CT detected the calculus in all 76 cases. There was a statistically significant difference in US-CT and CDUS-CT comparisons (p < 0.001 and p = 0.023, respectively); however, no difference was found when comparing both US methods with CT (p = 0.083). CONCLUSIONS: TA can be regarded as a significant marker of urolithiasis, and co-operative usage of Doppler and grayscale methods can yield satisfactory results comparable with CT.
[Mh] MeSH terms primary: Artifacts
Tomography, X-Ray Computed/methods
Ultrasonography, Doppler, Color/methods
Urolithiasis/radiography
Urolithiasis/ultrasonography
[Mh] MeSH terms secundary: Adult
Aged
Female
Humans
Kidney/radiography
Kidney/ultrasonography
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Ureter/radiography
Ureter/ultrasonography
Ureteral Calculi/radiography
Ureteral Calculi/ultrasonography
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140819
[St] Status:MEDLINE
[do] DOI:10.1007/s11604-014-0337-6

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[PMID]: 25152990
[Au] Autor:Piccinni G; Sciusco A; De Luca GM; Gurrado A; Pasculli A; Testini M
[Ad] Address:Unit of Endocrine, Digestive and Emergency Surgery; Department of Biomedical Sciences and Human Oncology, Section of General and Oncologic Surgery, University Medical School of Bari "Aldo Moro". Bari, Italy....
[Ti] Title:Minimally invasive treatment of Mirizzi's syndrome: is there a safe way? Report of a case series.
[So] Source:Ann Hepatol;13(5):558-64, 2014 Sep-Oct.
[Is] ISSN:1665-2681
[Cp] Country of publication:Mexico
[La] Language:eng
[Ab] Abstract:Mirizzi's syndrome (MS) is a rare complication of the inveterate biliary lithiasis. Diagnostic and therapeutic standardization is still missing, especially since laparoscopic cholecystectomy has become the gold standard approach for symptomatic cholelithiasis. Our study is a retrospective analysis based on a case-series. It considered 370 cholecystectomies performed from 2006 to 2011. We selected 11 patients affected by MS (2.97%). We divided them according to Csendes' classification. Endoscopic Retrograde Cholangio-Pancreatography (ERCP) was used for biliary drainage when the patient suffered jaundice and/or cholangitis and, preoperatively, to confirm the suspicion of MS obtained through Magnetic Resonance Cholangio-Pancreatography (MRCP). We found it useful to exploit nasobiliary drainage (NBD) for intra-operative check of the biliary tree. In all 5 patients of the type 1 group MS was discovered intraoperatively and treated with Laparoscopic Sub-total Cholecystectomy (LSC). One patient suffered from biliary leakage, solved with NBD positioning. The type 2 group was made up of 2 women and 1 man. All of them were preoperatively submitted to ERCP and NBD positioning. Two underwent LSC and one was converted to laparotomy. The type 3 was represented by a 63-year-old woman suffering from recurrent cholangitis. She was submitted to MRCP, ERCP and then underwent LSC. The 2 patients affected by type 4 underwent open biliary reconstruction. In conclusion, every attempt should be made to identify MS prior to LCS since it will allow NBD insertion by ERCP. Once LCS is initiated, if MS is identified intra-operatively, we can provide the most practical surgical options.
[Mh] MeSH terms primary: Cholecystectomy, Laparoscopic
Mirizzi Syndrome/surgery
[Mh] MeSH terms secundary: Adult
Aged
Cholangiopancreatography, Endoscopic Retrograde
Cholangiopancreatography, Magnetic Resonance
Cholecystectomy, Laparoscopic/adverse effects
Drainage/methods
Female
Humans
Male
Middle Aged
Mirizzi Syndrome/classification
Mirizzi Syndrome/diagnosis
Predictive Value of Tests
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140826
[St] Status:MEDLINE

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[PMID]: 24696006
[Au] Autor:Kirejczyk JK; Porowski T; Konstantynowicz J; Kozerska A; Nazarkiewicz A; Hoppe B; Wasilewska A
[Ad] Address:Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, Poland.
[Ti] Title:Urinary citrate excretion in healthy children depends on age and gender.
[So] Source:Pediatr Nephrol;29(9):1575-82, 2014 Sep.
[Is] ISSN:1432-198X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hypocitraturia is considered a major risk factor for calcium stone formation. However, there is no widely accepted reference database of urinary citrate excretion in children. The aim of our study was to determine the amount of citrate eliminated in the urine over a 24-h period in a pediatric cohort and to determine an optimal unit reflecting excretion. METHODS: The study cohort comprised 2,334 healthy boys and girls aged 2-18 years. The levels of urinary citrate were assessed by an enzymatic method in 24-hour urine and expressed in absolute values, as urinary concentration, citrate/creatinine ratio, per kilogram of body weight, in relation to 1.73 m2, and as the calcium/citrate index. RESULTS: Similar incremental age-related citraturia rates were observed in both male and female subjects until puberty during which time citrate excretion became significantly higher in girls. Urinary citrate adjusted for creatinine and for body weight showed a significantly decreasing trend with increasing age in both sexes. Urinary citrate corrected for body surface was weakly correlated with age. Thus, the assumption of 180 mg/1.73 m2/24 h for males and 250 mg/1.73 m2/24 h for females as lower cut-off values appeared to be reliable from a practical perspective. CONCLUSIONS: We found distinct sex-dependent differences in citraturia at the start of puberty, with significantly higher values of urinary citrate in girls than in boys. Further prospective studies are warranted to elucidate whether this difference represents a differentiated risk of urolithiasis.
[Mh] MeSH terms primary: Citric Acid/urine
Urolithiasis/urine
[Mh] MeSH terms secundary: Adolescent
Calcium/urine
Child
Child, Preschool
Cohort Studies
Creatinine/urine
Female
Humans
Male
Prospective Studies
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:2968PHW8QP (Citric Acid); AYI8EX34EU (Creatinine); SY7Q814VUP (Calcium)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140828
[St] Status:MEDLINE
[do] DOI:10.1007/s00467-014-2806-7

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[PMID]: 25883748
[Au] Autor:Grases F; Prieto RM; Fernandez-Cabot RA; Costa-Bauzá A; Tur F; Torres JJ
[Ad] Address:Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS), and University of Balearic Islands, Ctra. de Valldemossa Km 7.5, 07122 Palma de Mallorca, Spain ; CIBEROBN (CB06/03), Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5, 28029 Madrid, Spain....
[Ti] Title:Effects of polyphenols from grape seeds on renal lithiasis.
[So] Source:Oxid Med Cell Longev;2015:813737, 2015.
[Is] ISSN:1942-0994
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stress manifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1504
[Cu] Class update date: 150419
[Lr] Last revision date:150419
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1155/2015/813737

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[PMID]: 25927973
[Au] Autor:Piton N; Roquet ML; Sibert L; Sabourin JC
[Ad] Address:Department of Pathology, Rouen University Hospital, Rouen, France. nicolas.piton@cantab.net....
[Ti] Title:Focal non granulomatous orchitis in a patient with Crohn's disease.
[So] Source:Diagn Pathol;10(1):39, 2015.
[Is] ISSN:1746-1596
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Crohn's disease is a systemic disease and sometimes involves the testicle, usually leading to granulomatous lesions. We report herein a case of focal non-granulomatous orchitis in a 21-year-old patient with active Crohn's disease treated by an anti-tumor necrosis factor monoclonal antibody. This circumscribed testicular lesion mimicked a tumor, leading to orchiectomy. Pre-operative blood tests (i.e. alpha-fetoprotein, lactate dehydrogenase and human chorionic gonadotrophin) were strictly normal Pathological examination of the testicle revealed a focal inflammatory infiltrate predominantly composed of lymphocytes accompanied by few plasma cells, lacking giant cells or granulomas. Importantly, intratubular germ cell neoplasia, atrophy or lithiasis were not observed.After discussing and excluding other plausible causes (burnt-out /regressed germ cell tumor, infection, vascular or traumatic lesions, iatrogenic effects), we concluded that this particular case of orchitis was most likely an extra-digestive manifestation of inflammatory bowel disease. To our knowledge, this is the first described case of focal non-granulomatous orchitis associated with Crohn's disease. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2117747284160112.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150502
[Lr] Last revision date:150502
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s13000-015-0273-5

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[PMID]: 25866433
[Au] Autor:Perrier ET; Buendia-Jimenez I; Vecchio M; Armstrong LE; Tack I; Klein A
[Ad] Address:Danone Research, 91767 Palaiseau, France....
[Ti] Title:Twenty-four-hour urine osmolality as a physiological index of adequate water intake.
[So] Source:Dis Markers;2015:231063, 2015.
[Is] ISSN:1875-8630
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:While associations exist between water, hydration, and disease risk, research quantifying the dose-response effect of water on health is limited. Thus, the water intake necessary to maintain optimal hydration from a physiological and health standpoint remains unclear. The aim of this analysis was to derive a 24 h urine osmolality (U(Osm)) threshold that would provide an index of "optimal hydration," sufficient to compensate water losses and also be biologically significant relative to the risk of disease. Ninety-five adults (31.5 ± 4.3 years, 23.2 ± 2.7 kg·m(-2)) collected 24 h urine, provided morning blood samples, and completed food and fluid intake diaries over 3 consecutive weekdays. A U(Osm) threshold was derived using 3 approaches, taking into account European dietary reference values for water; total fluid intake, and urine volumes associated with reduced risk for lithiasis and chronic kidney disease and plasma vasopressin concentration. The aggregate of these approaches suggest that a 24 h urine osmolality ≤500 mOsm·kg(-1) may be a simple indicator of optimal hydration, representing a total daily fluid intake adequate to compensate for daily losses, ensure urinary output sufficient to reduce the risk of urolithiasis and renal function decline, and avoid elevated plasma vasopressin concentrations mediating the increased antidiuretic effort.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150416
[Lr] Last revision date:150416
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1155/2015/231063

  9 / 5848 MEDLINE  
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[PMID]: 25842572
[Au] Autor:Hussain M
[Ti] Title:Enormity of urolithiasis in Sindh province.
[So] Source:J Pak Med Assoc;64(12):1337-8, 2014 Dec.
[Is] ISSN:0030-9982
[Cp] Country of publication:Pakistan
[La] Language:eng
[Mh] MeSH terms primary: Urolithiasis/epidemiology
[Mh] MeSH terms secundary: Humans
Lithotripsy
Pakistan/epidemiology
Prevalence
Urolithiasis/therapy
Urolithiasis/ultrasonography
[Pt] Publication type:EDITORIAL
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150406
[St] Status:MEDLINE

  10 / 5848 MEDLINE  
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[PMID]: 25748695
[Au] Autor:Balzarotti R
[Ad] Address:Service de chirurgie, Ospedale Regionale di Lugano, Via Tesserete 46, 6900 Lugano, Switzerland. Electronic address: rubencarlo.balzarotticanger@eoc.ch.
[Ti] Title:Laparoscopic cholecystectomy and choledocolithotomy with primary suture for lithiasis (with video).
[So] Source:J Visc Surg;152(2):133-4, 2015 Apr.
[Is] ISSN:1878-7886
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review


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