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[PMID]: 27169740
[Au] Autor:Meola M; Samoni S; Petrucci I
[Ti] Title:Clinical Scenarios in Chronic Kidney Disease: Cystic Renal Diseases.
[So] Source:Contrib Nephrol;188:120-30, 2016.
[Is] ISSN:1662-2782
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Cysts are frequently found in chronic kidney disease (CKD) and they have a different prognostic significance depending on the clinical context. Simple solitary parenchymal cysts and peripelvic cysts are very common and they have no clinical significance. At US, simple cyst appears as a round anechoic pouch with regular and thin profiles. On the other hand, hereditary polycystic disease is a frequent cause of CKD in children and adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are the best known cystic hereditary diseases. ADPKD and ARPKD show a diffused cystic degeneration with cysts of different diameters derived from tubular epithelium. Medullary cystic disease may be associated with tubular defects, acidosis and lithiasis and can lead to CKD. Acquired cystic kidney disease, finally, is secondary to progressive structural end-stage kidney remodelling and may be associated with renal cell carcinoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1159/000445474

  2 / 6117 MEDLINE  
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[PMID]: 27169608
[Au] Autor:Meola M; Samoni S; Petrucci I
[Ti] Title:Clinical Scenarios in Chronic Kidney Disease: Chronic Tubulointerstitial Diseases.
[So] Source:Contrib Nephrol;188:108-19, 2016.
[Is] ISSN:1662-2782
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Chronic tubulointerstitial diseases are a common final pathway toward chronic renal failure regardless the primary damage (glomerular, vascular or directly the tubulointerstitium). Chronic tubulointerstitial nephritis (CTN) is characterized by interstitial scarring, fibrosis and tubule atrophy, resulting in progressive chronic kidney disease. Most frequent causes of CTN are drugs, heavy metals, obstructive uropathy, nephrolithiasis, reflux disease, immunologic diseases, neoplasia, ischemia, metabolic diseases, genetics and miscellaneous. At ultrasound (US), kidneys' morphological aspect is similar in all forms of chronic interstitial nephropathy and only chronic pyelonephritis with or without reflux shows distinguishing characteristics. In interstitial nephropathy, kidneys' profiles are finely irregular and corticomedullary differentiation is altered because of a diffused hyperechogenicity. The only indirect sign of chronic interstitial damage can be derived from the value of intrarenal resistive indexes that hardly overcome 0.75. US is mandatory in clinical chronic pyelonephritis work-up because it provides information on kidney's diameter and on growth nomogram in children. Renal profiles can be more or less altered depending on the number of cortical scars and the presence of pseudonodular areas of segmental compensatory hypertrophy. In the early stages, US diagnosis of renal tuberculosis is difficult because parenchymal lesions are non-specific. US sensitivity in the diagnosis of hydronephrosis is very high, close to 100% and, finally, US is the first choice imaging technique in the diagnosis of urinary lithiasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1159/000445473

  3 / 6117 MEDLINE  
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[PMID]: 27162601
[Au] Autor:Handra-Luca A
[Ad] Address:Department of Pathology, Paris Public Assistance Hospitals, North Paris Sorbonne Cité University, Avicenne Hospital University Group , Bobigny, France.
[Ti] Title:Granulomatous Lithiasic Cholecystitis in Sarcoidosis.
[So] Source:Clin Pract;6(1):811, 2016 Mar 25.
[Is] ISSN:2039-7275
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Gallbladder granulomas are exceedingly rare, reported in association with tuberculosis or sarcoidosis. Here we report a case of gallbladder granulomatous cholecystitis occurring in the context of sarcoidosis. A 70-years old man presented with abdominal pain, nausea and vomiting. The medical history revealed sarcoidosis diagnosed more than 20-years previously. 2-years previously the patient showed renal lithiasis, hypercalcemia and, increased angiotensin converting enzyme. The imaging features suggested thoraco-abdominal sarcoidosis. Prednisone was given at 1.2 mg/kg/day initially, than decreased, being at 2.5 mg/day at present. The ultrasound examination showed gallbladder lithiasis. A cholecystectomy was performed. Microscopy showed subacute and chronic cholecystitis with several epithelioid and giant cell granulomas some of them perineural. In conclusion, we report a case of granulomatous cholecystitis occurring in the course of treated sarcoidosis. The perineural location of granulomas may give further insights into the pathogenesis of gallbladder dysmotility.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 160512
[Lr] Last revision date:160512
[Da] Date of entry for processing:160510
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4081/cp.2016.811

  4 / 6117 MEDLINE  
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[PMID]: 26453970
[Au] Autor:Acuña M; González-Hódar L; Amigo L; Castro J; Morales MG; Cancino GI; Groen AK; Young J; Miquel JF; Zanlungo S
[Ad] Address:Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; FONDAP "Center for Genome Regulation" (CGR), Santiago, Chile....
[Ti] Title:Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice.
[So] Source:J Hepatol;64(2):361-9, 2016 Feb.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: Niemann-Pick C2 (NPC2) is a lysosomal protein involved in the egress of low-density lipoprotein-derived cholesterol from lysosomes to other intracellular compartments. NPC2 has been detected in several tissues and is also secreted from the liver into bile. We have previously shown that NPC2-deficient mice fed a lithogenic diet showed reduced biliary cholesterol secretion as well as cholesterol crystal and gallstone formation. This study aimed to investigate the consequences of NPC2 hepatic overexpression on liver cholesterol metabolism, biliary lipid secretion, gallstone formation and the effect of NPC2 on cholesterol crystallization in model bile. METHODS: We generated NPC2 transgenic mice (Npc2.Tg) and fed them either chow or lithogenic diets. We studied liver cholesterol metabolism, biliary lipid secretion, bile acid composition and gallstone formation. We performed cholesterol crystallization studies in model bile using a recombinant NPC2 protein. RESULTS: No differences were observed in biliary cholesterol content or secretion between wild-type and Npc2.Tg mice fed the chow or lithogenic diets. Interestingly, Npc2.Tg mice showed an increased susceptibility to the lithogenic diet, developing more cholesterol gallstones at early times, but did not show differences in the bile acid hydrophobicity and gallbladder cholesterol saturation indices compared to wild-type mice. Finally, recombinant NPC2 decreased nucleation time in model bile. CONCLUSIONS: These results suggest that NPC2 promotes cholesterol gallstone formation by decreasing the cholesterol nucleation time, indicating a pro-nucleating function of NPC2 in bile.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Process

  5 / 6117 MEDLINE  
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[PMID]: 26200544
[Au] Autor:Sujatha D; Singh K; Vohra M; Kumar KV; Sunitha S
[Ad] Address:Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, Andhrapradesh, India....
[Ti] Title:Antilithiatic Activity of phlorotannin rich extract of Sarghassum Wightii on Calcium Oxalate Urolithiais - InVitro and In Vivo Evaluation.
[So] Source:Int Braz J Urol;41(3):511-20, 2015 May-Jun.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:PURPOSE: Urolithiasis is a common urological disorder responsible for serious human affliction and cost to the society with a high recurrence rate. The aim of the present study was to systematically evaluate the phlorotannin rich extract of Sargassum wightii using suitable in vitro and in vivo models to provide scientific evidence for its antilithiatic activity. MATERIALS AND METHODS: To explore the effect of Sargassum wightii on calcium oxalate crystallization, in vitro assays like crystal nucleation, aggregation and crystal growth were performed. Calcium oxalate urolithiasis was induced in male Sprague dawley rats using a combination of gentamicin and calculi producing diet (5% ammonium oxalate and rat pellet feed). The biochemical parameters like calcium, oxalate, magnesium, phosphate, sodium and potassium were evaluated in urine, serum and kidney homogenates. Histopathological studies were also done to confirm the biochemical findings. RESULTS: The yield of Sargassum wightii extract was found to be 74.5 gm/kg and confirmed by quantitative analysis. In vitro experiments with Sargassum wightii showed concentration dependent inhibition of calcium oxalate nucleation, aggregation and growth supported by SEM analysis. In the in vivo model, Sargassum wightii reduced both calcium and oxalate supersaturation in urine, serum and deposition in the kidney. The biochemical results were supported by histopathological studies. CONCLUSION: The findings of the present study suggest that Sargassum wightii has the ability to prevent nucleation, aggregation and growth of calcium oxalate crystals. Sargassum wightii has better preventive effect on calcium oxalate stone formation indicating its strong potential to develop as a therapeutic option to prevent recurrence of urolithiasis.
[Mh] MeSH terms primary: Calcium Oxalate/antagonists & inhibitors
Plant Extracts/pharmacology
Sargassum/chemistry
Tannins/pharmacology
Urolithiasis/prevention & control
[Mh] MeSH terms secundary: Animals
Calcium/analysis
Calcium Oxalate/chemistry
Crystallization
Kidney/drug effects
Magnesium/analysis
Male
Models, Animal
Oxalates/analysis
Phosphorus/analysis
Random Allocation
Rats, Sprague-Dawley
Reference Values
Reproducibility of Results
Time Factors
Treatment Outcome
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Name of substance:0 (Oxalates); 0 (Plant Extracts); 0 (Tannins); 2612HC57YE (Calcium Oxalate); 27YLU75U4W (Phosphorus); I38ZP9992A (Magnesium); SY7Q814VUP (Calcium)
[Em] Entry month:1512
[Cu] Class update date: 160512
[Lr] Last revision date:160512
[Js] Journal subset:IM
[Da] Date of entry for processing:150723
[St] Status:MEDLINE
[do] DOI:10.1590/S1677-5538.IBJU.2014.0357

  6 / 6117 MEDLINE  
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[PMID]: 26200543
[Au] Autor:Vaitheeswari S; Sriram R; Brindha P; Kurian GA
[Ad] Address:School of Chemical and Biotechnology, SASTRA University, Thanjavur, T. N, India....
[Ti] Title:Studying inhibition of calcium oxalate stone formation: an in vitro approach for screening hydrogen sulfide and its metabolites.
[So] Source:Int Braz J Urol;41(3):503-10, 2015 May-Jun.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:PURPOSE: Calcium oxalate urolithiasis is one of the most common urinary tract diseases and is of high prevalence. The present study proposes to evaluate the antilithiatic property of hydrogen sulfide and its metabolites like thiosulfate & sulfate in an in vitro model. MATERIALS AND METHODS: The antilithiatic activity of sodium hydrogen sulfide (NaSH), sodium thiosulfate (Na(2)S(2)O(3)) and sodium sulfate (Na(2)SO(4)) on the kinetics of calcium oxalate crystal formation was investigated both in physiological buffer and in urine from normal and recurrent stone forming volunteers. The stones were characterized by optical and spectroscopic techniques. RESULTS: The stones were characterized to be monoclinic, prismatic and bipyramidal habit which is of calcium monohydrate and dihydrate nature. The FTIR displayed fingerprint corresponding to calcium oxalate in the control while in NaSH treated, S=O vibrations were visible in the spectrum. The order of percentage inhibition was NaSH>Na(2)S(2)O(3)>Na(2)SO(4). CONCLUSION: Our study indicates that sodium hydrogen sulfide and its metabolite thiosulfate are inhibitors of calcium oxalate stone agglomeration which makes them unstable both in physiological buffer and in urine. This effect is attributed to pH changes and complexing of calcium by S(2)O(3)(2)-and SO(4)(2)- moiety produced by the test compounds.
[Mh] MeSH terms primary: Calcium Oxalate/metabolism
Hydrogen Sulfide/chemistry
Hydrogen Sulfide/metabolism
Urolithiasis/metabolism
Urolithiasis/prevention & control
[Mh] MeSH terms secundary: Adult
Analysis of Variance
Calcium Oxalate/chemistry
Case-Control Studies
Female
Humans
Male
Reproducibility of Results
Spectroscopy, Fourier Transform Infrared
Urine/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:2612HC57YE (Calcium Oxalate); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Entry month:1512
[Cu] Class update date: 160512
[Lr] Last revision date:160512
[Js] Journal subset:IM
[Da] Date of entry for processing:150723
[St] Status:MEDLINE
[do] DOI:10.1590/S1677-5538.IBJU.2014.0193

  7 / 6117 MEDLINE  
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[PMID]: 27018408
[Au] Autor:Oida T; Kanemitsu T; Hayashi T; Fujimoto N; Koide T
[Ad] Address:The Departments of Urology, Japan Community Health care Organization Osaka Hospital....
[Ti] Title:[Percutaneous Nephrolithotripsy for Renal Transplant Lithiasis: A Case Report].
[So] Source:Hinyokika Kiyo;62(2):69-71, 2016 Feb.
[Is] ISSN:0018-1994
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:A 54-year-old man was introduced to our hospital for follow-up examinations after renal transplantation. At the initial visit, a 25 mm renal transplant stone was noted, which had enlarged to 32 mm at an examination 1 year later. We first attempted transurethral lithotripsy (TUL), but failed due to ureteral stricture. However, we could completely remove the stone in 2 sessions of percutaneous nephrolithotripsy (PNL). The incidence of urinary lithiasis after renal transplantation ranges from 0.17-1.8%, for which PNL and TUL are frequently used. Although considered to be accompanied with risks of bleeding, bowel injury, and renal dysfunction, PNL is effective for urinary lithiasis after renal transplantation. TUL is less invasive, but access may be difficult when the ureter has an unusual course or ureteral stricture exists, as in our patient.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process

  8 / 6117 MEDLINE  
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[PMID]: 26717117
[Au] Autor:Glina FP; Castro PM; Monteiro GG; Del Guerra GC; Glina S; Mazzurana M; Bernardo WM
[Ad] Address:Faculdade de Ciencias Medicas de Santos, Centro Universitario Lusiada, Santos, Sao Paulo, Brasil....
[Ti] Title:The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis.
[So] Source:Int Braz J Urol;41(6):1049-57, 2015 Nov-Dec.
[Is] ISSN:1677-6119
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Urinary lithiasis is the main urologic cause of emergency treatment in adult patient. In the past years, the incidence in children population has increased. However, literature about the use of alpha-1 adrenergic blockers in pediatric population with distal ureterolithiasis is still scarce. The drug acts by decreasing ureter contractions, especially in the distal portion, facilitating calculus expulsion. OBJECTIVE: This review has the objective to evaluate the use of alpha-1 adrenergic blockers as medical expulsive treatment in children with distal ureterolithiasis. EVIDENCE ACQUISITION: An electronic literature search was performed using the MEDLINE, COCHRANE, and LILACS databases. We further searched manually the references of the primary studies. Searches were concluded on October 4th, 2014. Articles were selected, independently and in pairs, by the respective titles and summaries. Any divergence was resolved by consensus. EVIDENCE SYNTHESIS: Alpha-1 adrenergic antagonists increased the probability of calculus expulsion by 27% (NNT=4). Calculi smaller than 5mm, increased by 33% (NNT=3). Larger than 5mm, increased by 34% (NNT=3). CONCLUSION: Alpha-1 adrenergic blocker use is related with a greater incidence of expulsion of ureteral calculi, smaller or greater than 5mm, and fewer episodes of pain when compared to ibuprofen. However it is necessary larger samples to enhance the power analysis of the expulsion of ureteral calculi larger than 5mm and the episodes of pain. PATIENT SUMMARY: This review analyzed the outcome of alpha adrenergic antagonist in children with ureteral calculi. We conclude that it is the best medicine for use, since it helps the expulsion of the stone.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1512
[Cu] Class update date: 160510
[Lr] Last revision date:160510
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1590/S1677-5538.IBJU.2015.0048

  9 / 6117 MEDLINE  
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[PMID]: 26121543
[Au] Autor:Ye X; Ni K; Zhou X; Xie K; Hong X
[Ad] Address:Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Yinzhou Second Hospital, Ningbo, China.
[Ti] Title:Laparoscopic Left Hemihepatectomy for Left-sided Hepatolithiasis.
[So] Source:Surg Laparosc Endosc Percutan Tech;25(4):347-50, 2015 Aug.
[Is] ISSN:1534-4908
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Hepatolithiasis is a prevalent disease in the southeastern coastal regions of China. Partial hepatectomy is the most definitive treatment for hepatolithiasis. This study evaluated the safety and efficacy of the laparoscopic left hemihepatectomy (LLH) for left-sided hepatolithiasis. METHODS: The clinical data of 37 consecutive patients who underwent pure LLH for left-sided hepatolithiasis at Yinzhou Second Hospital between March 2009 and December 2013 were reviewed retrospectively. RESULTS: Pure LLH was performed successfully in 36 patients. Because of severe adhesions from previous choledochotomy, 1 patient was converted to open procedure. The mean operative time was 257.9 minutes (range, 188 to 396 min). The mean duration of postoperative hospital stay was 11.7 days (range, 8 to 21 d). There were 2 (5.4 %) cases of postoperative bile leakage, 2 (5.4%) cases of intra-abdominal fluid collection, and 1 (2.7%) case of incisional infection, which were successfully managed conservatively. Residual stones were observed in 2 (5.4%) patients. The residual stones were located in the common bile duct in these cases and were removed through the T-tube tract by choledochoscopy. During a mean follow-up of 31.3 months (range, 6 to 63 mo), recurrent stones were detected in 2 (5.4%) patients and were successfully treated with endoscopic sphincterotomy. CONCLUSIONS: LLH for left-sided hepatolithiasis is feasible and safe in selected patients.
[Mh] MeSH terms primary: Bile Ducts, Intrahepatic/surgery
Hepatectomy/methods
Laparoscopy/methods
Lithiasis/surgery
Liver Diseases/surgery
[Mh] MeSH terms secundary: Adult
Aged
Female
Humans
Male
Middle Aged
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:150805
[St] Status:MEDLINE
[do] DOI:10.1097/SLE.0000000000000173

  10 / 6117 MEDLINE  
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[PMID]: 23801377
[Au] Autor:Granata A; Floccari F; Clementi A; Di Lullo L; Fiorini F
[Ad] Address:Department of Nephrology and Dialysis, "San Giovanni di Dio" Hospital, ASP, Agrigento, Italy, antonio.granata4@tin.it.
[Ti] Title:Contrast-enhanced ultrasound reveals renal artery aneurysm after detection of 'parapelvic lithiasis'.
[So] Source:Clin Exp Nephrol;18(1):174-5, 2014 Feb.
[Is] ISSN:1437-7799
[Cp] Country of publication:Japan
[La] Language:eng
[Mh] MeSH terms primary: Aneurysm/ultrasonography
Contrast Media
Kidney Calculi/ultrasonography
Kidney Pelvis/blood supply
Kidney Pelvis/ultrasonography
Renal Artery/ultrasonography
Ultrasonography, Doppler, Color
Vascular Calcification/ultrasonography
[Mh] MeSH terms secundary: Aged
Aneurysm/radiography
Diagnosis, Differential
Female
Humans
Kidney Pelvis/radiography
Predictive Value of Tests
Renal Artery/radiography
Tomography, X-Ray Computed
Vascular Calcification/radiography
[Pt] Publication type:CASE REPORTS; LETTER
[Nm] Name of substance:0 (Contrast Media)
[Em] Entry month:1605
[Js] Journal subset:IM
[Da] Date of entry for processing:140213
[St] Status:MEDLINE
[do] DOI:10.1007/s10157-013-0829-1


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