Database : MEDLINE Search on : Lycoris [Words] References found : 102 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 29253598 [Au] Autor: Bendaif H; Melhaoui A; Ramdani M; Elmsellem H; Douez C; El Ouadi Y [Ad] Address: Laboratory of Macromolecular Organic Chemistry and Natural Products (URAC25), Faculty of Science, 60000 Oujda, Morocco. Electronic address: h.bendaif@ump.ac.ma. [Ti] Title: Antibacterial activity and virtual screening by molecular docking of lycorine from Pancratium foetidum Pom (Moroccan endemic Amaryllidaceae). [So] Source: Microb Pathog;115:138-145, 2017 Dec 15. [Is] ISSN: 1096-1208 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Lycorine is an alkaloid isolated from bulbs of Pancratium foetidum Pom Amaryllidaceae of the genus Lycoris. It has very strong pharmacodynamics properties and biological effects, among others, antimalarial, antiviral, antitumor, and anti-inflammatory. Lycorine has been identified and characterized by thin layer chromatography, IR and NMR (1H and 13C NMR, COZY, HMBC, HSQC and NOESY). The antibacterial activity of lycorine has been evaluated. Lycorine has a moderate antibacterial activity on the majority of strains studied, nevertheless it is more effective than Streptomycin and Ampicillin against bacteria: P. aeruginosa, En. cloacae. To confirm these results, it is necessary to use qualitative techniques and methods, etc… We performed a virtual docking ligand-lycorine protein screening study to predict and characterize their mode of interaction with the LpxC receptor. Docking results have shown that lycorine can interact with target amino residues studied by hydrogen and metal-ion bonds. In addition, the ADME-Tox profile study has shown that lycorine is all in agreement, either with Lipinski's critics or with the toxicity standards. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1712 [Cu] Class update date: 180303 [Lr] Last revision date: 180303 [St] Status: Publisher

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[PMID]: 29318848 [Au] Autor: Xie D; Wu Y; Xiao JW; Xie ZX; Chen YX; He WQ; Zhang DG [Ad] Address: College of Biology and Environmental Sciences, Jishou University, Jishou 416000, China. [Ti] Title: [New records of medicinal plants in Hubei]. [So] Source: Zhongguo Zhong Yao Za Zhi;42(22):4436-4440, 2017 Nov. [Is] ISSN: 1001-5302 [Cp] Country of publication: China [La] Language: chi [Ab] Abstract: In this paper, we make a report on new records of medicinal plants in Hubei, which include one newly recorded genera and seven newly recorded species and a newly recorded variety. The newly recorded genera is Anoectochilus and its corresponding species is Anoectochilus roxburghii; These newly recorded species are Euphorbia micractina, Astragalus wulingensis, Blumea megacephala, Potentilla saundersiana, Blumea formosana, Lycoris houdyshelii and Colocasia gigantea ; The newly recorded variety is Neottia puberula var. maculata. Among these species, Anoectochilus roxburghii and N. puberula var. maculata are considered as the second-class protection in our country, A. roxburghii is regarded as Endangered（EN）and Astragalus wulingensis is regarded as Critically Endangered (CN) by IUCN. The report of these newly recorded plants borden the distribution and enrich the plant diversity of Hubei. [Pt] Publication type: ENGLISH ABSTRACT; JOURNAL ARTICLE [Em] Entry month: 1801 [Cu] Class update date: 180110 [Lr] Last revision date: 180110 [St] Status: In-Data-Review [do] DOI: 10.19540/j.cnki.cjcmm.2017.0197

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[PMID]: 28947170 [Au] Autor: Zhou P; Wu Z; Tan D; Yang J; Zhou Q; Zeng F; Zhang M; Bie Q; Chen C; Xue Y; Luo Z; Wang J; Zhu H; Zhang Y [Ad] Address: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, People's Republic of China. [Ti] Title: Atrichodermones A-C, three new secondary metabolites from the solid culture of an endophytic fungal strain, Trichoderma atroviride. [So] Source: Fitoterapia;123:18-22, 2017 Nov. [Is] ISSN: 1873-6971 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: An endophytic fungal strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata. Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A (1), a new cyclopentenone derivative, atrichodermone B (2), and a new sesquiterpene, atrichodermone C (3), together with three known cyclopentenone derivatives (4-6) were isolated. Their structures were elucidated by extensive spectroscopic (UV, IR, ECD, HRESIMS, and NMR) data analyses, and absolute configurations of the new compounds were determined by comparing their experimental ECD spectra with structurally similar compounds and computational analyses of their electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for their cytotoxicity against HL60 and U937 cell lines, as well as anti-inflammatory effect against the production of the pro-inflammatory cytokines TNF-α and IL-1ß. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1709 [Cu] Class update date: 171115 [Lr] Last revision date: 171115 [St] Status: In-Process

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[PMID]: 28441543 [Au] Autor: Sun S; Wei Y; Cao Y; Deng B [Ad] Address: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. [Ti] Title: Simultaneous electrochemiluminescence determination of galanthamine, homolycorine, lycorenine, and tazettine in Lycoris radiata by capillary electrophoresis with ultrasonic-assisted extraction. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1055-1056:15-19, 2017 Jun 15. [Is] ISSN: 1873-376X [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: After ultrasonic-assisted extraction, four lycoris radiata alkaloids: galanthamine, homolycorine, lycorenine, and tazettine were determined by capillary electrophoresis electrochemiluminescence. Polyvinylpyrrolidone was added to the running buffer (RB) to obtain better resolution. Experimental conditions influencing the determination were examined, including the additives, detection potential, separation voltage, injection voltage and time, and RB pH and concentration. Under optimal experimental conditions, the baseline separation of the four alkaloids occurred within 16min. The proposed method displayed the following linear ranges (in ng/mL): galanthamine [60-5000], homolycorine [40-5000], lycorenine [5.0-1500], and tazettine [8.0-2500]. The detection limits in ng/mL, (S/N=3), were galanthamine [14], homolycorine [11], lycorenine [1.8], and tazettine [3.1]. Intra-day and inter-day RSDs for the four alkaloids of the six replicates were less than 2.7% and 3.1%, respectively. The recoveries in% were: tazettine [102.5], lycorenine [98.20], galanthamine [97.30], and homolycorine [98.33]. [Mh] MeSH terms primary: Amaryllidaceae Alkaloids/analysis Electrophoresis, Capillary/methods Galantamine/analysis Luminescent Measurements/methods Lycoris/chemistry [Mh] MeSH terms secundary: Amaryllidaceae Alkaloids/isolation & purification Buffers Electrophoresis, Capillary/economics Galantamine/isolation & purification Limit of Detection Luminescent Measurements/economics Plant Extracts/chemistry Povidone/chemistry Sonication/methods [Pt] Publication type: JOURNAL ARTICLE [Nm] Name of substance: 0 (Amaryllidaceae Alkaloids); 0 (Buffers); 0 (Plant Extracts); 0D3Q044KCA (Galantamine); 477-19-0 (lycorenine); 477-20-3 (homolycorine); 76WEU12CSO (tazettine); FZ989GH94E (Povidone) [Em] Entry month: 1706 [Cu] Class update date: 171116 [Lr] Last revision date: 171116 [Js] Journal subset: IM [Da] Date of entry for processing: 170426 [St] Status: MEDLINE

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[PMID]: 28240308 [Au] Autor: Quan M; Liang J [Ad] Address: College of Biological and Food Engineering, Huaihua University, Huaihua, Hunan 418008, P. R. China. [Ti] Title: The influences of four types of soil on the growth, physiological and biochemical characteristics of Lycoris aurea (L' Her.) Herb. [So] Source: Sci Rep;7:43284, 2017 Feb 27. [Is] ISSN: 2045-2322 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Based on the characteristics of Lycoris aurea (L. aurea) natural distribution and local soil types, we selected four representative types of soil, including humus soil, sandy soil, garden soil and yellow-brown soil, for conducting the cultivation experiments to investigate key soil factors influencing its growth and development and to select the soil types suitable for cultivating it. We found that there existed significant differences in the contents of mineral elements and the activities of soil enzymes (urease, phosphatase, sucrase and catalase) etc. Among which, the contents of organic matters, alkali-hydrolysable nitrogen, Ca and Mg as well as the activities of soil enzymes in humus soil were the highest ones. In yellow-brown soil, except for Fe, the values of all the other items were the lowest ones. Net photosynthetic rate (P ), biomass and lycorine content in humus soil were all the highest ones, which were increased by 31.02, 69.39 and 55.79%, respectively, as compared to those of yellow-brown soil. Stepwise multiple regression analysis and path analysis indicated that alkali-hydrolysable nitrogen, and Ca etc. were key soil factors influencing P , biomass and lycorine content of L. aurea. Thus, humus soil can be used as medium suitable for artificial cultivation of L. aurea. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1702 [Cu] Class update date: 170305 [Lr] Last revision date: 170305 [St] Status: In-Data-Review [do] DOI: 10.1038/srep43284

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[PMID]: 28111578 [Au] Autor: Wang R; Xu S; Wang N; Xia B; Jiang Y; Wang R [Ad] Address: Institute of Botany, Jiangsu Province and Chinese Academy of SciencesNanjing, China; The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural GermplasmNanjing, China. [Ti] Title: Transcriptome Analysis of Secondary Metabolism Pathway, Transcription Factors, and Transporters in Response to Methyl Jasmonate in . [So] Source: Front Plant Sci;7:1971, 2016. [Is] ISSN: 1664-462X [Cp] Country of publication: Switzerland [La] Language: eng [Ab] Abstract: , a medicinal species of the Amaryllidaceae family, is used in the practice of traditional Chinese medicine (TCM) because of its broad pharmacological activities of Amaryllidaceae alkaloids. Despite the officinal and economic importance of species, the secondary mechanism for this species is relatively deficient. In this study, we attempted to characterize the transcriptome profiling of seedlings with the methyl jasmonate (MeJA) treatment to uncover the molecular mechanisms regulating plant secondary metabolite pathway. By using short reads sequencing technology (Illumina), two sequencing cDNA libraries prepared from control (Con) and 100 µM MeJA-treated (MJ100) samples were sequenced. A total of 26,809,842 and 25,874,478 clean reads in the Con and MJ100 libraries, respectively, were obtained and assembled into 59,643 unigenes. Among them, 41,585 (69.72%) unigenes were annotated by basic local alignment search tool similarity searches against public sequence databases. These included 55 Gene Ontology (GO) terms, 128 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and 25 Clusters of Orthologous Groups (COG) families. Additionally, 4,175 differentially expressed genes (DEGs; false discovery rate ≤ 0.001 and |log Ratio| ≥ 1) with 2,291 up-regulated and 1,884 down-regulated, were found to be affected significantly under MeJA treatment. Subsequently, the DEGs encoding key enzymes involving in the secondary metabolite biosynthetic pathways, transcription factors, and transporter proteins were also analyzed and summarized. Meanwhile, we confirmed the altered expression levels of the unigenes that encode transporters and transcription factors using quantitative real-time PCR (qRT-PCR). With this transcriptome sequencing, future genetic and genomics studies related to the molecular mechanisms associated with the chemical composition of may be improved. Additionally, the genes involved in the enrichment of secondary metabolite biosynthesis-related pathways could enhance the potential applications of . [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1701 [Cu] Class update date: 170816 [Lr] Last revision date: 170816 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.3389/fpls.2016.01971

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[PMID]: 27922057 [Au] Autor: Chen GL; Tian YQ; Wu JL; Li N; Guo MQ [Ad] Address: Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China. [Ti] Title: Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. [So] Source: Sci Rep;6:38284, 2016 Dec 06. [Is] ISSN: 2045-2322 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Crude Amaryllidaceae alkaloids (AAs) extracted from Lycoris radiata are reported to exhibit significant anti-cancer activity. However, the specific alkaloids responsible for the pharmacodynamic activity and their targets still remain elusive. In this context, we strived to combine affinity ultrafiltration with topoisomerase I (Top I) as a target enzyme aiming to fish out specific bioactive AAs from Lycoris radiata. 11 AAs from Lycoris radiata were thus screened out, among which hippeastrine (peak 5) with the highest Enrichment factor (EF) against Top I exhibited good dose-dependent inhibition with IC at 7.25 ± 0.20 µg/mL comparable to camptothecin (positive control) at 6.72 ± 0.23 µg/mL. The molecular docking simulation further indicated the inhibitory mechanism between Top I and hippeastrine. The in vitro antiproliferation assays finally revealed that hippeastrine strongly inhibited the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC values at 3.98 ± 0.29 µg/mL and 11.85 ± 0.20 µg/mL, respectively, and also induced significant cellular morphological changes, which further validated our screening method and the potent antineoplastic effects. Collectively, these results suggested that hippeastrine could be a very promising anticancer candidate for the therapy of cancer in the near future. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1612 [Cu] Class update date: 170220 [Lr] Last revision date: 170220 [St] Status: In-Data-Review [do] DOI: 10.1038/srep38284

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[PMID]: 27911369 [Au] Autor: Yamaji F; Ohsawa TA [Ad] Address: Department of Biology, Chiba University. [Ti] Title: Field Experiments of Pollination Ecology: The Case of Lycoris sanguinea var. sanguinea. [So] Source: J Vis Exp;(117), 2016 Nov 25. [Is] ISSN: 1940-087X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Plant-pollinator interactions have been studied for approximately one hundred years. During that time, many field methods have been developed to clarify the pollination effectiveness of each pollinator for visited flowers. Pollinator observations have been one of the most common methods to identify pollinators, and bagging and cage experiments have been conducted to show the effectiveness of specific pollinators. In a previous study of Lycoris sanguinea var. sanguinea, its effective pollinators, the visitation frequencies of each floral visitor, and its reproductive strategies were not identified. This study reports the observation that small bees visited flowers that were partially opened (breaking buds). To the best of our knowledge, this phenomenon has not been reported previously. Further, this study investigates the hypothesis that small bees can pollinate at that flowering stage. This study demonstrates the basic methods of field experiments in pollination ecology using L. sanguinea var. sanguinea. Pollinator observations and digital video showed the visitation frequencies of each floral visitor. Bagging and cage experiments revealed that these flowers could be pollinated fully and that breaking-bud pollination could be important for the pollination of this plant species. The advantages and disadvantages of each method are discussed, and recent developments, including laboratory experiments, are described. [Mh] MeSH terms primary: Lycoris Pollination [Mh] MeSH terms secundary: Animals Bees Ecology Flowers [Pt] Publication type: JOURNAL ARTICLE; VIDEO-AUDIO MEDIA [Em] Entry month: 1709 [Cu] Class update date: 170911 [Lr] Last revision date: 170911 [Js] Journal subset: IM [Da] Date of entry for processing: 161203 [St] Status: MEDLINE [do] DOI: 10.3791/54728

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[PMID]: 27724902 [Au] Autor: Xu S; Jiang Y; Wang N; Xia B; Jiang Y; Li X; Zhang Z; Li Y; Wang R [Ad] Address: Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China. [Ti] Title: Identification and differential regulation of microRNAs in response to methyl jasmonate treatment in Lycoris aurea by deep sequencing. [So] Source: BMC Genomics;17(1):789, 2016 10 10. [Is] ISSN: 1471-2164 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: BACKGROUND: Lycoris aurea is a medicine-valuable and ornamental herb widely distributed in China. Former studied have showed that methyl jasmonate (MJ) treatment could increase the content of glanthamine-a worldwide medicine for symptomatic treatment of Alzheimer's disease in genus Lycoris plants. To explore the possible role of miRNAs in the regulation of jasmonic acid signaling pathway and uncover their potential correlations, we investigated the expression profiles of small RNAs (sRNAs) and their targets in Lycoris aurea, with MJ treatment by using next-generation deep sequencing. RESULTS: A total of 365 miRNAs were identified, comprising 342 known miRNAs (representing 60 miRNA families) and 23 novel miRNAs. Among them, 143 known and 11 novel miRNAs were expressed differently under MJ treatment. Quantitative real-time PCR of eight selected miRNAs validated the expression pattern of these loci in response to MJ treatment. In addition, degradome sequencing analysis showed that 32 target genes were validated to be targeted by the 49 miRNAs, respectively. Gene function and pathway analyses showed that these targets such as auxin response factors (ARFs), squamosa promoter-binding like (SPL) proteins, basic helix-loop-helix (bHLH) proteins, and ubiquitin-conjugating enzyme E2 are involved in different plant processes, indicating miRNAs mediated regulation might play important roles in L. aurea response to MJ treatment. Furthermore, several L. aurea miRNAs associated with their target genes that might be involved in Amaryllidaceae alkloids biosynthehsis were also analyzed. CONCLUSIONS: A number of miRNAs with diverse expression patterns, and complex relationships between expression of miRNAs and targets were identified. This study represents the first transcriptome-based analysis of miRNAs in Lycoris and will contribute to understanding the potential roles of miRNAs involved in regulation of MJ response. [Mh] MeSH terms primary: Acetates/pharmacology Cyclopentanes/pharmacology Gene Expression Regulation, Plant/drug effects Lycoris/drug effects Lycoris/genetics MicroRNAs/genetics Oxylipins/pharmacology Plant Growth Regulators/pharmacology RNA, Plant [Mh] MeSH terms secundary: Cluster Analysis Computational Biology Evolution, Molecular Gene Expression Profiling High-Throughput Nucleotide Sequencing Reproducibility of Results Transcriptome [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Acetates); 0 (Cyclopentanes); 0 (MicroRNAs); 0 (Oxylipins); 0 (Plant Growth Regulators); 0 (RNA, Plant); 900N171A0F (methyl jasmonate) [Em] Entry month: 1709 [Cu] Class update date: 171119 [Lr] Last revision date: 171119 [Js] Journal subset: IM [Da] Date of entry for processing: 161012 [St] Status: MEDLINE

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[PMID]: 27539422 [Au] Autor: Chen G; Tian Y; Guo M [Ad] Address: Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China. [Ti] Title: Screening for inhibitors of topoisomerase I from Lycoris radiata by combining ultrafiltration with liquid chromatography/mass spectrometry. [So] Source: Rapid Commun Mass Spectrom;30 Suppl 1:95-9, 2016 Aug. [Is] ISSN: 1097-0231 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: RATIONALE: Although crude Amaryllidaceae alkaloids (AAs) extracted from Lycoris radiata are reported to exhibit significant anti-cancer activity, both the specific responsible alkaloid(s) and their targets remain elusive. Screening anti-cancer AAs targeted on topoisomerase I from crude AAs could be very helpful in tackling these two challenging questions. METHODS: An ultrafiltration method combined with liquid chromatography/electrospray ionization mass spectrometry (UF-LC/MS) was developed to screen for the inhibitors of topoisomerase I, which has been reported to mediate DNA unwinding during carcinoma proliferation. Enrichment factors (EFs) of different AAs were used to evaluate the binding affinity between AAs and topoisomerase I, and the AAs with higher EFs were further tested to validate the method. RESULTS: Eleven AAs from Lycoris radiata (ten of which were identified) were screened using UF-LC/MS, and a glaring discrepancy in EFs was revealed for the first time. One of the AAs, hippeastrine, with the highest EF at 49.3%, was further tested against topoisomerase I, and the IC50 value of hippeastrine was determined to be 23.0 µmol/L, which is comparable with the well-known anti-cancer drug camptothecin at 19.3 µmol/L. CONCLUSIONS: A simple, rapid and effective screening method using UF-LC/MS was developed and successfully applied to screen candidate inhibitors of topoisomerase I from crude AAs in Lycoris radiata, which may pave the way to further understand the potential anti-cancer constituents and mechanisms of Lycoris radiata. Copyright © 2016 John Wiley & Sons, Ltd. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1608 [Cu] Class update date: 160819 [Lr] Last revision date: 160819 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1002/rcm.7649

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