Database : MEDLINE
Search on : Lymphocytes [Words]
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[PMID]: 25152129
[Au] Autor:Wang K; Hou Y; Wang X; Han G
[Ad] Address:Department of Clinical Laboratory, Affiliated Hospital of Taishan Medical College, Shandong Taian 271000, China....
[Ti] Title:[Expression kinetics of CD69 molecule by CD3⁺ lymphocytes and γδT cells under three different activating modalities].
[So] Source:Zhonghua Xue Ye Xue Za Zhi;35(8):753-4, 2014 Aug 14.
[Is] ISSN:0253-2727
[Cp] Country of publication:China
[La] Language:chi
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0253-2727.2014.08.020

  2 / 441836 MEDLINE  
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[PMID]: 25093281
[Au] Autor:Lv X; Yang J; Song H; Li T; Guo L; Xing Y; Xi T
[Ad] Address:Biotechnology Center, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: lvxiaobo_007@163.com....
[Ti] Title:Therapeutic efficacy of the multi-epitope vaccine CTB-UE against Helicobacter pylori infection in a Mongolian gerbil model and its microRNA-155-associated immuno-protective mechanism.
[So] Source:Vaccine;32(41):5343-52, 2014 Sep 15.
[Is] ISSN:1873-2518
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Vaccination is an effective means of preventing infectious diseases, including those caused by Helicobacter pylori. In this study, we constructed a novel multi-epitope vaccine, CTB-UE, composed of the cholera toxin B subunit and tandem copies of the B and Th cell epitopes from the H. pylori urease A and B subunits. We evaluated the therapeutic efficacy of the multi-epitope vaccine CTB-UE against H. pylori infection in a Mongolian gerbil model and studied its immuno-protective mechanisms. The experimental results indicated that urease activity, H. pylori colonisation density, the levels of IL-8 and TNF-α in the serum, and the levels of COX-2 and NAP in gastric tissue were significantly lower and the IgG level in the serum and the IFN-γ level in spleen lymphocytes were significantly higher in the vaccinated group compared with the model control group; additionally, gastric mucosal inflammation was notably alleviated following vaccination. The results showed that CTB-UE had a good therapeutic effect on H. pylori infection. The immuno-protective mechanism was closely related to the immune response mediated by microRNA-155, the expression of which was strongly up-regulated after CTB-UE administration. The expression levels of the microRNA-155 target proteins IFN-γRα, AID, and PU.1 were significantly down-regulated; these results indicated that CTB-UE induced an immune response biased towards Th1 cells by up-regulating microRNA-155 to inhibit IFN-γRα expression and induced a humoral immune response towards B cells by up-regulating microRNA-155 to inhibit PU.1 and AID expression. These results demonstrate that the multi-epitope vaccine CTB-UE may be a promising therapeutic vaccine against H. pylori infection and is a new therapeutic tool for human use.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 441836 MEDLINE  
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[PMID]: 25103252
[Au] Autor:Liu XD; Zhang FB; Zhou B; Shan H; Chen PY
[Ad] Address:Division of Key Lab of Animal Disease Diagnosis and Immunology of China's Department of Agriculture, Nanjing Agricultural University, Nanjing 210095, China; College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China....
[Ti] Title:Effect of sonication on different quality parameters of Pinus massoniana pollen.
[So] Source:Ultrason Sonochem;22:174-81, 2015 Jan.
[Is] ISSN:1873-2828
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:A study was initiated with the objective of evaluating the effects of sonication treatment on important quality parameters of extract of Pinus massoniana pollen. Sonication of extract was done (frequency 20kHz and various amplitude levels) for 10, 30, 50min, respectively. As results, total polysaccharide, phenolics and flavonoids significantly increased (P<0.05). And sonicated P.massoniana pollen displays strong immuno-stimulating activity by increasing proliferations of splenic lymphocytes and subsets of CD4+ T cells (CD3+CD4+), CD8 T cells (CD3+CD8+), and increased Ig secretion. Sonicated P. massoniana pollen also showed anti-tumor function by inhibition of tumor cell proliferation, inhibition of ROS production, up-regulation of GSH/GSSG ration, up-regulating the gene expression of P53, Bax and down-regulating the gene expression of Bcl-2. Findings of the present study suggested the sonication treatment of P. massoniana pollen could improve the quality and bioactivity of P. massoniana pollen, indicating that sonication is effective in processing of pollen and could be a potential process in tumor prevention and treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 441836 MEDLINE  
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[PMID]: 25151006
[Au] Autor:Wohn CT; Pantelyushin S; Ober-Blbaum JL; Clausen BE
[Ad] Address:Department of Immunology, Erasmus MC, University Medical Center Rotterdam, 3015 GE, Rotterdam, The Netherlands.
[Ti] Title:Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.
[So] Source:Methods Mol Biol;1193:171-85, 2014.
[Is] ISSN:1940-6029
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Psoriasis is a chronic auto-inflammatory skin disease of unknown etiology affecting millions of people worldwide. Dissecting the cellular networks and molecular signals promoting the development of psoriasis critically depends on appropriate animal models. Topical application of Aldara cream containing the Toll-like receptor (TLR)7-ligand Imiquimod induces skin inflammation and pathology in mice closely resembling plaque-type psoriasis in humans. The particular power of the Aldara model lies in examining the early events during psoriatic plaque formation, which is difficult to achieve in patients. Hence, recent reports using this model have challenged currently prevailing concepts concerning the pathophysiology of psoriasis. Here, we describe the induction and phenotype of Aldara-mediated dermatitis in mice and, in particular, analysis of the inflammatory cell infiltrate using flow cytometry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/978-1-4939-1212-4_16

  5 / 441836 MEDLINE  
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[PMID]: 25150994
[Au] Autor:Ludwig-Portugall I; Kurts C
[Ad] Address:Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
[Ti] Title:T cell isolation from mouse kidneys.
[So] Source:Methods Mol Biol;1193:27-35, 2014.
[Is] ISSN:1940-6029
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The kidneys contain very few lymphocytes under homeostatic conditions. One kidney from a healthy mouse per average contains only 1-5 10(3) CD4(+) T cells. In immune-mediated kidney disease, γδ T cells, NKT cells, CD4(+) T cells, CD8(+) T cells, and regulatory T cells (Treg) infiltrate the kidney. Their numbers and subset composition of infiltrating T cells varies between the different forms of nephritis. For example, in glomerulonephritis CD4(+) T cells mediate renal injury, by local cytokine production, effector cell activation and/or by helping B cells to produce nephritogenic antibodies. A better understanding of the pathomechanisms of immune-mediated kidney diseases requires a method to isolate T cells from the kidney for ex vivo analysis. Here we describe an effective and specific isolation protocol for T cells from the murine kidney.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/978-1-4939-1212-4_4

  6 / 441836 MEDLINE  
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[PMID]: 25150993
[Au] Autor:Reiig S; Hackenbruch C; Hvelmeyer N
[Ad] Address:Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg-University, Obere Zahlbacher Str. 67, 55131, Mainz, Germany, reissig@uni-mainz.de.
[Ti] Title:Isolation of T cells from the gut.
[So] Source:Methods Mol Biol;1193:21-5, 2014.
[Is] ISSN:1940-6029
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The lymphocytes of epithelial and lamina proprial compartments of the intestine are phenotypically and functionally distinct and serve a wide range of functions in the intestinal mucosa like regulating intestinal homeostasis, maintaining epithelial barrier function as well as regulating adaptive and innate immune responses. To analyze the role of these cells in different disease states, it is necessary to isolate pure cell populations of the intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL) of the gut. In this protocol we describe a method to isolate T cells from IEL and LPL, which can be used for further investigations like comparative studies of mRNA expression, cell proliferation assay, or protein analysis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/978-1-4939-1212-4_3

  7 / 441836 MEDLINE  
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[PMID]: 25064379
[Au] Autor:Kuklina EM
[Ad] Address:Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Goleva Str. 13, Perm, Russian Federation. Electronic address: ibis_07@mail.ru.
[Ti] Title:Melatonin as potential inducer of Th17 cell differentiation.
[So] Source:Med Hypotheses;83(3):404-6, 2014 Sep.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The subset of T lymphocytes producing IL-17 (Th17) plays a key role in the immune system. It has been implicated in host defense, inflammatory diseases, tumorigenesis, autoimmune diseases, and transplant rejection. Careful analysis of the data available holds that Th17 cell subpopulation should be under the direct control of pineal hormone melatonin: the key Th17 differentiation factor RORα serves in the meantime as a high-affinity melatonin receptor. Since the levels of melatonin have diurnal and seasonal variation, as well as substantial deviations in some physiological or pathological conditions, melatonin-dependent regulation of Th17 cells should implicate multiform manifestation, such as influencing the outcome of infectious challenge or determining predisposition, etiology and progression of immunerelated morbidities. Another important reason to raise a point of the new melatonin effects is current considering the possibilities of its clinical trials. Especially, the differentiation of Th17 upon melatonin treatment must aggravate the current recession in autoimmune diseases or induce serious complications in pregnancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 441836 MEDLINE  
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[PMID]: 24487059
[Au] Autor:Nasi M; Pinti M; Mussini C; Cossarizza A
[Ad] Address:Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy....
[Ti] Title:Persistent inflammation in HIV infection: Established concepts, new perspectives.
[So] Source:Immunol Lett;161(2):184-8, 2014 Oct.
[Is] ISSN:1879-0542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Immune activation is now considered a main driving force for the progressive immune failure in HIV infection. During the early phases of infection, a rapid depletion of gastrointestinal CD4+ T cells occurs that is followed by a deterioration of the gut epithelium and by the subsequent translocation of microbial products into the blood. Activation of innate immunity results in massive production of proinflammatory cytokines, which can trigger activation induced cell death phenomena among T lymphocytes. Moreover, persistent antigenic stimulation and inflammatory status causes immune exhaustion. The chronic immune activation also damages lymphoid tissue architecture, so contributing to the impairment of immune reconstitution. Recently, new mechanisms were identified, so opening new perspective on the innate immune sensing in HIV-1 infection. Cell death is followed by the release of molecules containing "damage-associated molecular patterns", that trigger a potent innate immune response through the engagement of Toll-like receptors. Then, also different types of HIV-related nucleic acids can act as potent stimulators of innate immunity. All these events contribute to the loss of T cell homeostatic regulation and to the failure of adaptive immunity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 441836 MEDLINE  
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[PMID]: 24365064
[Au] Autor:Matarese G; Colamatteo A; De Rosa V
[Ad] Address:Dipartimento di Medicina e Chirurgia, Universit di Salerno, Baronissi Campus, Baronissi 84081, Salerno, Italy; IRCCS-MultiMedica, Milano 20138, Italy. Electronic address: gmatarese@unisa.it.
[Ti] Title:Metabolic fuelling of proper T cell functions.
[So] Source:Immunol Lett;161(2):174-8, 2014 Oct.
[Is] ISSN:1879-0542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 441836 MEDLINE  
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[PMID]: 25151732
[Au] Autor:Jin J; Zhang HJ; Wang XJ; Zhou WQ; Yin DL; Chen XG
[Ti] Title:[Effect of a novel selective S1P1 agonist, Syl948, on mouse skin transplantation].
[So] Source:Yao Xue Xue Bao;49(5):627-31, 2014 May.
[Is] ISSN:0513-4870
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Syl948 is a synthesized selective S1P1 agonist with novel structure. HTRF-IP1 test indicated that Syl948-P, the active form of Syl948 in vitro, has strong activity against S1P1 (EC50: 83 +/- 16 nmol x L(-1)), but its effect on S1P3 was very weak (EC50: 1 026 +/- 90 nmol x L(-1)). In SD rats, oral administration of Syl948 10 mg x kg(-1) significantly decreased the peripheral blood lymphocytes (PBL), with the maximal PBL inhibition rate of 63%, which was as similar as equal dose of fingolimod (FTY720). Oral administration of Syl948 10 mg x kg(-1) had no effect on heart rate of SD rats, which was better than FTY720. Daily oral administration with Syl948 (2 or 4 mg x kg(-1)) significantly prolonged the survival time of the allografts of skin slice on mice. In summary, the above results demonstrated that Syl948 has great selectivity in vitro and good activity in vivo, which indicated its potential use as an anti-rejection drug in skin transplantation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process


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