Database : MEDLINE
Search on : Lymphomatoid and Papulosis [Words]
References found : 846 [refine]
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[PMID]: 29510190
[Au] Autor:Sun J; Yi S; Qiu L; Fu W; Wang A; Liu F; Wang L; Wang T; Chen H; Wang L; Kadin ME; Tu P; Wang Y
[Ad] Address:Department of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing 100034, China.
[Ti] Title:SATB1 defines a subtype of cutaneous CD30+ lymphoproliferative disorders associated with a T-helper-17 cytokine profile.
[So] Source:J Invest Dermatol;, 2018 Mar 03.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cutaneous CD30+ lymphoproliferative disorder (CD30+LPDs), including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma (PCALCL), comprises the second most common group of cutaneous T cell lymphoma. Previously, we reported that special AT-rich sequence-binding protein1 (SATB1), a thymocyte specific chromatin organizer, was over-expressed and promoted malignant T-cell proliferation in a portion of CD30+LPDs. Here, we investigated the expression pattern of SATB1 in CD30+LPDs with a large cohort of patient samples, and examined the potential of SATB1 as a molecular marker to classify CD30+LPDs with differential clinicopathological behaviors. SATB1 expression was identified in the CD30+ anaplastic T cells in 11 of 12 (91.7%) LyP and 16 of 42 (38.1%) PCALCL cases. SATB1+ cases showed T-helper (Th)-17 polarization, together with more prominent epidermal hyperplasia and granulocytic infiltration. SATB1+ lesions responded better to combined treatment of methotrexate and interferon. SATB1 activated the expression of Th17 cytokines while repressing Th1 related genes. The heterogeneity in SATB1 expression across CD30+LPDs was associated with the extent of promoter DNA methylation. Hence, SATB1 expression defines a subtype of CD30+LPDs with characteristic pathobiology and prognosis. These data provide valuable insights into the heterogeneity of cutaneous T cell malignancies, which may lead to individualized therapy in the future.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  2 / 846 MEDLINE  
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[PMID]: 29318585
[Au] Autor:Ghahramani GK; Goetz KE; Liu V
[Ad] Address:Department of Dermatology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
[Ti] Title:Dermoscopic characterization of cutaneous lymphomas: a pilot survey.
[So] Source:Int J Dermatol;57(3):339-343, 2018 Mar.
[Is] ISSN:1365-4632
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures. METHODS: Fifteen patients with an established diagnosis of cutaneous lymphoma were prospectively recruited and seen in the university multidisciplinary cutaneous lymphoma program with MF, an MF- variant, CD30-positive lymphoproliferative disorder, or cutaneous B-cell lymphomas and were included in our study. Dermoscopic findings, histologic features, clinical characteristics, and demographic data were analyzed. RESULTS: Patch stage MF was characterized by interconnected white structureless patches encircling small fine linear vessels, yielding an overall trabeculated to fenestrated pattern under dermoscopy. Corresponding histopathologic findings for these patterns included epidermotropism, atypical pleomorphic cells, and lichenoid infiltrates. Folliculotropic mycosis fungoides (FMF) was characterized by folliculocentric erosions surrounded by dotted and fine linear vessels, loss of terminal follicles, comedo-like openings, and interconnected regular-appearing structureless patches. Corresponding histopathologic findings in these FMF cases were typical of FMF. Notably, these changes were not appreciated in lymphomatoid papulosis. Primary cutaneous follicle center B cell lymphoma showed crystalline structures and vascular pseudopods. CONCLUSIONS: Cutaneous lymphomas appear to demonstrate characteristic dermoscopic patterns, reflective of the specific lymphoma type and its corresponding histopathology, which have not been seen in inflammatory skin conditions, such as psoriasis and eczematous dermatitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Process
[do] DOI:10.1111/ijd.13860

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[PMID]: 29378678
[Au] Autor:Hori-Kosogabe J; Hamada T; Morizane S; Hirai Y; Miyake T; Yoshino T; Iwatsuki K
[Ad] Address:Department of Dermatology.
[Ti] Title:Type D (CD8+) lymphomatoid papulosis in a patient with classic (CD4+) mycosis fungoides.
[So] Source:Eur J Dermatol;, 2018 Jan 29.
[Is] ISSN:1952-4013
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180130
[Lr] Last revision date:180130
[St] Status:Publisher
[do] DOI:10.1684/ejd.2018.3234

  4 / 846 MEDLINE  
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[PMID]: 29361381
[Au] Autor:Magro CM; Daniels BH; Crowson AN
[Ad] Address:Weill Cornell Medicine, Department of Pathology & Laboratory Medicine, 1300 York Avenue, F-309, New York, NY 10065, United States. Electronic address: cym2003@med.cornell.edu.
[Ti] Title:Drug induced pseudolymphoma.
[So] Source:Semin Diagn Pathol;, 2018 Jan 17.
[Is] ISSN:0740-2570
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. The implicated drug classes are quite varied and include antidepressants, antihistamines, calcium channel blockers, statins, anticonvulsants, and various biologic drugs. The drugs from these various drug classes exert certain effects on lymphoid function including evoking overzealous responses to other antigenic stimuli. As the adverse effect on lymphocyte function may be cumulative over years and or reflect the interplay of other drugs, a temporal association may not exist between the onset of the rash/lesion and the initiation of the drug. In certain lymphomatoid reactions however such as DRESS syndrome the drug may function as both an antigen as well as an immune dysregulating agent. It is critical that the pathologist works carefully with the clinician in the evaluation of all atypical cutaneous lymphoid infiltrates where the distinction between pseudolymphoma versus lymphoma cannot be reliably made based on pathologic analysis alone.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:Publisher

  5 / 846 MEDLINE  
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[PMID]: 29315771
[Au] Autor:Zang JB; Coates SJ; Huang J; Vonderheid EC; Cohen BA
[Ad] Address:Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
[Ti] Title:Pityriasis lichenoides: Long-term follow-up study.
[So] Source:Pediatr Dermatol;, 2018 Jan 09.
[Is] ISSN:1525-1470
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND/OBJECTIVES: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center. METHODS: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. RESULTS: Fifty (67%) patients were diagnosed with pityriasis lichenoides chronica, 22 (29%) with pityriasis lichenoides et varioliformis acuta, and 3 (4%) with mixed pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta features. Mean ± standard deviation age at onset was 12 ± 13 years (median 8 years). Disease duration was significantly shorter for patients with pityriasis lichenoides et varioliformis acuta (35 ± 35 months) than for those with pityriasis lichenoides chronica (at least 78 ± 48 months). At long-term follow-up, 23 of 28 (82%) patients with pityriasis lichenoides chronica and 3 of 16 (19%) with pityriasis lichenoides et varioliformis acuta had active disease. None progressed to lymphomatoid papulosis or cutaneous T-cell lymphoma. Ten of 23 active pityriasis lichenoides chronica cases had residual pigmentary change independent of race and lasted at least 35 ± 20 months. The most effective treatments were phototherapy (47% response rate), heliotherapy (33%), topical corticosteroids (27%), and antibiotics (25%). CONCLUSION: Pityriasis lichenoides is a predominantly pediatric disorder. The time course of pityriasis lichenoides chronica is significantly longer than that of pityriasis lichenoides et varioliformis acuta. Pityriasis lichenoides chronica may persist with pigmentary alterations in the absence of other signs of active inflammation. Treatment response is often limited, particularly for patients with pityriasis lichenoides chronica.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:Publisher
[do] DOI:10.1111/pde.13396

  6 / 846 MEDLINE  
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[PMID]: 29222219
[Au] Autor:Patel PU
[Ad] Address:Department of Dermatology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
[Ti] Title:An uncommon diagnosis for a recurrent erythematous patch in a paediatric patient.
[So] Source:BMJ Case Rep;2017, 2017 Dec 07.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 14-year-old girl presented with a circular erythematous patch over the left buttock for approximately 10 years, with ongoing ulceration and papules developing over the last 4 years. Punch biopsies were taken within and above the patch for diagnosis. Both revealed marked inflammatory infiltrates with atypical, irregular lymphocytes and increased mitosis. Immunostaining revealed CD8 positivity and a pan T helper cell phenotype. T cell receptor gene rearrangement analysis showed T cell clonality in both biopsies. These findings were consistent with mycosisfungoides and associated lymphomatoid papulosis. Both are rare conditions but have been associated in 5%-20% of cases. A definitive association has not yet been established; however, T cell monoclonality shows 50%-60% share a common origin. Management options are extensive with no one treatment showing superiority. Our patient received low-dose radiotherapy with good outcomes, but subsequently required further radiotherapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171209
[Lr] Last revision date:171209
[St] Status:In-Process

  7 / 846 MEDLINE  
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[PMID]: 29171911
[Au] Autor:Caccavale S; Vitiello P; Mascolo M; Ciancia G; Argenziano G
[Ad] Address:Dermatology Unit, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.
[Ti] Title:Dermoscopy of different stages of lymphomatoid papulosis.
[So] Source:J Eur Acad Dermatol Venereol;, 2017 Nov 24.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 47-year-old man presented with a 3-year history of asymptomatic, erythematous papules and nodules located on his trunk, buttocks and limbs (Fig.1). Lesions were at different stages of clinical development: some were crusted or ulcerated, other necrotic or cicatricial. The patient's medical history was not relevant. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher
[do] DOI:10.1111/jdv.14706

  8 / 846 MEDLINE  
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[PMID]: 29171395
[Au] Autor:Maurelli M; Tessari G; Colato C; Schena D; Girolomoni G
[Ad] Address:Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
[Ti] Title:Incidence and ten-year follow-up of primary cutaneous lymphomas: a single-centre cohort study.
[So] Source:Eur J Dermatol;, 2017 Nov 24.
[Is] ISSN:1952-4013
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Primary cutaneous lymphomas (PCLs) are a rare group of extranodal non-Hodgkin lymphomas, and epidemiological data in Mediterranean countries are scarce. OBJECTIVE: To investigate the incidence and characteristics of PCL in a single tertiary referral centre in Italy. MATERIALS & METHODS: A total of 141 PCL patients, seen over a 10-year follow-up period, were investigated. RESULTS: Incidence rate of PCL was 0.8 cases/100,000 person years. T-cell lymphoma represented 78.7% of all cases, the majority being early mycosis fungoides (MF) (64%; median age: 66 years), followed by lymphomatoid papulosis (LyP) (19%; median: age 48 years), and others (median age: 72 years), including eight cases of anaplastic large CD30+ T-cell lymphoma, four CD4+ small-medium pleomorphic T-cell lymphoproliferative disorder, four Sézary syndrome, one subcutaneous panniculitis-like T-cell lymphoma, one extranodal NK/T-cell lymphoma nasal-type, and one angioimmunoblastic T-cell lymphoma. B-cell lymphoma accounted for 21.3% of PCL, with 20 cases of cutaneous follicular centre B-cell (median age: 63 years), four primary cutaneous marginal zone, three primary cutaneous diffuse large B-cell, and three leg-type lymphoma. Complete remission within the first year after diagnosis occurred in 70.4% of MF, 61.9% of LyP, 78.9% of other T-cell lymphoma, and 93.1% of B-cell lymphoma cases. Based on a Cox proportional hazard regression model, age, gender, stage, and lactate dehydrogenase and ß2-microglobulin blood levels did not predict clinical remission of MF or LyP. CONCLUSIONS: The incidence and characteristics of PCL in Italy are similar to those in other European countries. PCLs may be diagnosed at very early stages with good prognosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher
[do] DOI:10.1684/ejd.2017.3183

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[PMID]: 29146059
[Au] Autor:Schwartz Z; Coleman M; Toyohara JP; Freedman PD; Magro CM
[Ad] Address:Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA; SUNY Downstate College of Medicine, 450 Clarkson Ave, Brooklyn, NY 11203, USA.
[Ti] Title:Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma.
[So] Source:Ann Diagn Pathol;31:50-55, 2017 Dec.
[Is] ISSN:1532-8198
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+ LPD). More specifically the original report and subsequent authors suggest that the patients fall on the spectrum of CD30+ LPD most reminiscent of Lymphomatoid papulosis (LyP) seen in the skin. This oral variant of LyP would be expected to have the same diverse morphologic spectrum as that seen in cutaneous LyP. We present five EUOM patients whose biopsies showed an atypical lymphocytic infiltrate most compatible with Type C LyP, a histologically unique subset of LyP, reminiscent of the biopsy findings encountered in the reported case by Ficarra and co-workers. (Ficarra, et al., 1997) In four of the five cases, the biopsies were interpreted by expert hematopathologists as an aggressive form of peripheral T cell lymphoma resulting in recommendations to administer systemic chemotherapy to four of the patients, the scheduling of one patient for induction therapy and transplantation before revision of the diagnosis, and administration of chemotherapy to one of the patients. The natural clinical course of spontaneous regression refuted the original diagnoses as a form of aggressive peripheral T cell lymphoma. Recognition of oral LyP is critical to avoid inadvertent exposure to potentially toxic chemotherapeutic regimens intended for the treatment of high grade lymphoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:In-Process

  10 / 846 MEDLINE  
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[PMID]: 29067932
[Au] Autor:Pindado-Ortega C; Fonda-Pascual P; Buendía-Castaño D; Fernández-González P; Peña-Jaimes L; Carrillo-Gijón R
[Ad] Address:Department of Dermatology, Hospital Ramon Y Cajal, Madrid, Spain.
[Ti] Title:An unusual case of lymphomatoid papulosis type E with extensive necrosis.
[So] Source:Indian J Dermatol Venereol Leprol;, 2017 Aug 28.
[Is] ISSN:0973-3922
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Lymphomatoid papulosis type E (LyP) is a recently described subtype of LyP characterized by an angioinvasive infiltrate of atypical lymphocytes expressing CD30. We present a case of type E LyP with extensive cutaneous necrosis in the histopathological evaluation which was misdiagnosed as an ulcerative form of bacterial skin infection. The remarkable cutaneous necrosis showed in our case might be related to the angiodestructive infiltrate that was present in this circumstance.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:Publisher
[do] DOI:10.4103/ijdvl.IJDVL_871_16


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