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[PMID]: 28950715
[Au] Autor:Tanjung M; Rachmadiarti F; Saputri RD; Tjahjandarie TS
[Ad] Address:a Natural Products Chemistry Research Group, Organic Chemistry Division, Faculty of Science and Technology, Department of Chemistry , Universitas Airlangga , Surabaya , Indonesia.
[Ti] Title:Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm.
[So] Source:Nat Prod Res;:1-6, 2017 Sep 26.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1) along with three known compounds, mammea A/BA cyclo F (2), calolongic acid (3) and isocalolongic acid (4) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1-4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 1 gave moderate activity with IC 6.26 µg/mL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170927
[Lr] Last revision date:170927
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1378215

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[PMID]: 28573218
[Au] Autor:Sangkaruk R; Rungrojsakul M; Tima S; Anuchapreeda S
[Ad] Address:Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200 Thailand.
[Ti] Title:EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES.
[So] Source:Afr J Tradit Complement Altern Med;14(2):16-24, 2017.
[Is] ISSN:2505-0044
[Cp] Country of publication:Nigeria
[La] Language:eng
[Ab] Abstract:BACKGROUND: Saraphi is a Thai traditional herb. In this study, the cytotoxic effects of crude ethanolic and fractional extracts including hexane, ethyl acetate, and methanol fractions from flowers were investigated in order to determine their effect on WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 cells. MATERIALS AND METHODS: The flowers of were extracted using ethanol. The ethanol flower extract was further fractionated with hexane, ethyl acetate, and methanol. Cytotoxic effects were measured by the MTT assay. Bcr/Abl and WT1 protein levels after treatments were determined by Western blotting. The total cell number was determined the typan blue exclusion method. RESULTS: The hexane fraction showed the strongest cytotoxic activity on Molt4 and K562 cells, with IC values of 2.6 and 77.6 µg/ml, respectively. The hexane extract decreased Bcr/Abl protein expression in K562 cells by 74.6% and WT1 protein expressions in Molt4 and K562 cells by 68.4 and 72.1%, respectively. Total cell numbers were decreased by 66.2 and 48.7% in Molt4 and K562 cells, respectively. Mammea E/BB (main active compound) significantly decreased both Bcr/Abl and WTlprotein expressions by 75 and 49.5%, respectively when compared to vehicle control. CONCLUSION: The hexane fraction from flowers inhibited cell proliferation the suppression of WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 cells. The active compound may be mammea E/BB. Extracts from flowers show promise as naturally occurring anti-cancer drugs.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/therapeutic use
Fusion Proteins, bcr-abl/metabolism
Leukemia/drug therapy
Mammea
Phytotherapy
Plant Extracts/therapeutic use
WT1 Proteins/metabolism
[Mh] MeSH terms secundary: Antineoplastic Agents, Phytogenic/pharmacology
Cell Proliferation
Flowers
Humans
K562 Cells
Leukemia/metabolism
Medicine, Traditional
Oncogene Proteins v-abl/metabolism
Plant Extracts/pharmacology
Proto-Oncogene Proteins c-bcr/metabolism
Thailand
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Oncogene Proteins v-abl); 0 (Plant Extracts); 0 (WT1 Proteins); 0 (WT1 protein, human); 0 (abl-bcr fusion protein, human); EC 2.7.10.2 (Fusion Proteins, bcr-abl); EC 2.7.11.1 (BCR protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins c-bcr)
[Em] Entry month:1708
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[Js] Journal subset:IM
[Da] Date of entry for processing:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.3

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[PMID]: 28551236
[Au] Autor:Péroumal A; Adenet S; Rochefort K; Fahrasmane L; Aurore G
[Ad] Address:Université des Antilles, UMR 1270 QUALITROP, F-97 110 Pointe-à-Pitre, France. Electronic address: armelle_peroumal@yahoo.fr.
[Ti] Title:Variability of traits and bioactive compounds in the fruit and pulp of six mamey apple (Mammea americana L.) accessions.
[So] Source:Food Chem;234:269-275, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Our objective was to compare fruit morphology, physico-chemistry and bioactive compounds content of the edible pulp of six Mammea americana accessions. The results showed that this fruit was rather big, weighing on average 600 to 1100g depending on the accession, and spherical to oblate-shaped. The pulp represented between 50 and 70% of the weight of the whole fruit. The pulp adhered only partially to the seeds in 5 of the 6 accessions studied, while the last one exhibited full adherence. The fresh pulp was acidic, sweet, succulent and crunchy. The fruits studied had a variety of qualities, providing various opportunities for post-harvest uses: fruit salads, nectar preparation, jams and jellies, or export. We have established for the first time the total phenolic compounds and total flavonoids contents in the pulp of mamey apple fruits. The pulp colour was highly correlated with total phenolic compounds and total carotenoids contents.
[Mh] MeSH terms primary: Carotenoids/chemistry
Flavonoids/chemistry
Fruit/chemistry
Mammea/chemistry
Phenols/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Flavonoids); 0 (Phenols); 36-88-4 (Carotenoids)
[Em] Entry month:1708
[Cu] Class update date: 170808
[Lr] Last revision date:170808
[Js] Journal subset:IM
[Da] Date of entry for processing:170529
[St] Status:MEDLINE

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[PMID]: 28504908
[Au] Autor:Li C; Jeong Y; Kim M
[Ad] Address:1 College of Tourism and Culinary Science, Yangzhou University , Yangzhou, China .
[Ti] Title:Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53.
[So] Source:J Med Food;20(5):485-490, 2017 May.
[Is] ISSN:1557-7600
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The methanol extract of Mammea longifolia Planch. and Triana (M. longifolia) fruit was studied for anticancer and apoptotic effects in the SW480 colon cancer cell line. The apoptotic and necrotic effects of M. longifolia were detected by 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT) and lactate dehydrogenase assays, respectively. One hundred µg/mL of the extract killed ∼82.4% of the cells; however, 2% of the death was related to necrosis. The morphological changes in M. longifolia-stimulated SW480 cells were observed directly by light microscopy. DNA fragmentation assay was employed to analyze the apoptosis induction. M. longifolia-treated SW480 cells promoted the expression of Bax, Bad, cleaved-poly-ADP-ribose polymerase (PARP), and p53 proteins and decreased the protein expression of pro-caspases Bcl-2 and Bcl-XL. The ratios of Bax/Bcl-2 and cleaved-PARP/PARP, predictive markers of apoptotic stimuli in cancer, increased and may play an important role in regulating the progression of apoptosis. The results suggested that M. longifolia induces cell death via mitochondrial-related apoptosis in SW480 cells.
[Mh] MeSH terms primary: Apoptosis/drug effects
Colonic Neoplasms/physiopathology
Mammea/chemistry
Mitochondria/drug effects
Plant Extracts/pharmacology
Tumor Suppressor Protein p53/metabolism
[Mh] MeSH terms secundary: Cell Line, Tumor
Colonic Neoplasms/genetics
Colonic Neoplasms/metabolism
DNA Fragmentation/drug effects
Fruit/chemistry
Humans
Mitochondria/genetics
Mitochondria/metabolism
Poly(ADP-ribose) Polymerases/genetics
Poly(ADP-ribose) Polymerases/metabolism
Proto-Oncogene Proteins c-bcl-2/genetics
Proto-Oncogene Proteins c-bcl-2/metabolism
Tumor Suppressor Protein p53/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
[Em] Entry month:1708
[Cu] Class update date: 170822
[Lr] Last revision date:170822
[Js] Journal subset:IM
[Da] Date of entry for processing:170516
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.3865

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[PMID]: 28100218
[Au] Autor:Gómez-Calderón C; Mesa-Castro C; Robledo S; Gómez S; Bolivar-Avila S; Diaz-Castillo F; Martínez-Gutierrez M
[Ad] Address:Grupo de Investigación en Ciencias Animales-GRICA, Universidad Cooperativa de Colombia, Calle 30A # 33-51, Bucaramanga, Colombia.
[Ti] Title:Antiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infections.
[So] Source:BMC Complement Altern Med;17(1):57, 2017 Jan 18.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The transmission of Dengue virus (DENV) and Chikungunya virus (CHIKV) has increased worldwide, due in part to the lack of a specific antiviral treatment. For this reason, the search for compounds with antiviral potential, either as licensed drugs or in natural products, is a research priority. The objective of this study was to identify some of the compounds that are present in Mammea americana (M. americana) and Tabernaemontana cymosa (T. cymosa) plants and, subsequently, to evaluate their cytotoxicity in VERO cells and their potential antiviral effects on DENV and CHIKV infections in those same cells. METHODS: Dry ethanolic extracts of M. americana and T. cymosa seeds were subjected to open column chromatographic fractionation, leading to the identification of four compounds: two coumarins, derived from M. americana; and lupeol acetate and voacangine derived from T. cymosa.. The cytotoxicity of each compound was subsequently assessed by the MTT method (at concentrations from 400 to 6.25 µg/mL). Pre- and post-treatment antiviral assays were performed at non-toxic concentrations; the resulting DENV inhibition was evaluated by Real-Time PCR, and the CHIKV inhibition was tested by the plating method. The results were analyzed by means of statistical analysis. RESULTS: The compounds showed low toxicity at concentrations ≤ 200 µg/mL. The compounds coumarin A and coumarin B, which are derived from the M. americana plant, significantly inhibited infection with both viruses during the implementation of the two experimental strategies employed here (post-treatment with inhibition percentages greater than 50%, p < 0.01; and pre-treatment with percentages of inhibition greater than 40%, p < 0.01). However, the lupeol acetate and voacangine compounds, which were derived from the T. cymosa plant, only significantly inhibited the DENV infection during the post-treatment strategy (at inhibition percentages greater than 70%, p < 0.01). CONCLUSION: In vitro, the coumarins are capable of inhibiting infection by DENV and CHIKV (with inhibition percentages above 50% in different experimental strategies), which could indicate that these two compounds are potential antivirals for treating Dengue and Chikungunya fever. Additionally, lupeol acetate and voacangine efficiently inhibit infection with DENV, also turning them into promising antivirals for Dengue fever.
[Mh] MeSH terms primary: Antiviral Agents/therapeutic use
Chikungunya Fever/drug therapy
Dengue/drug therapy
Mammea/chemistry
Plant Extracts/therapeutic use
Tabernaemontana/chemistry
[Mh] MeSH terms secundary: Animals
Cercopithecus aethiops
Cytotoxins/toxicity
Mammea/toxicity
Plant Extracts/toxicity
Tabernaemontana/toxicity
Vero Cells
Virus Replication/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antiviral Agents); 0 (Cytotoxins); 0 (Plant Extracts)
[Em] Entry month:1701
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:170120
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1562-1

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Silveira, Thaís Gomes Verzignassi
Lonardoni, Maria Valdrinez Campana
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[PMID]: 27224267
[Au] Autor:Cardoso BM; De Mello TF; Lera DS; Brenzan MA; Cortez DA; Donatti L; Silveira TG; Lonardoni MV
[Ad] Address:Programa de Pós-Graduação em Biociências e Fisiopatologia, Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, PR, Brazil.
[Ti] Title:Antileishmanial Activity of a Calophyllum brasiliense Leaf Extract.
[So] Source:Planta Med;83(1-02):57-62, 2017 Jan.
[Is] ISSN:1439-0221
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:(Clusiaceae) is a tree that grows mainly in the Atlantic Forest in Brazil. Its leaves possess antibacterial activity, cytotoxic activity against certain tumor cell lines, and antimicrobial activity in BALB/c mice infected with .Aiming to identify ultrastructural changes and DNA fragmentation in promastigotes were treated with a concentration of the dichloromethane extract and coumarin (-) mammea A/BB from leaves that inhibited 50 % of the parasites (IC ), and were evaluated by transmission and scanning electron microscopy. Ultrastructural changes showed different levels of mitochondrial alterations, including mitochondrial swelling and a reduction in the density of the mitochondrial matrix. Induced DNA fragmentation, as observed by TUNEL, suggested that the extract and coumarin (-) mammea A/BB induced apoptosis-like cell death. These results suggest that the combination of extract and coumarin (-) mammea A/BB can be considered a promising candidate for the development of new antiprotozoal agents, because of its significant leishmanicidal activity.
[Mh] MeSH terms primary: Antiprotozoal Agents/pharmacology
Calophyllum/chemistry
Coumarins/pharmacology
Leishmania braziliensis/drug effects
Leishmaniasis, Cutaneous/drug therapy
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Animals
Anti-Bacterial Agents/chemistry
Anti-Bacterial Agents/isolation & purification
Anti-Bacterial Agents/pharmacology
Antiprotozoal Agents/chemistry
Antiprotozoal Agents/isolation & purification
Brazil
Cell Death/drug effects
Cell Line, Tumor
Coumarins/chemistry
Coumarins/isolation & purification
DNA Fragmentation/drug effects
Leishmania braziliensis/ultrastructure
Leishmaniasis, Cutaneous/parasitology
Methylene Chloride
Mice
Mice, Inbred BALB C
Plant Extracts/chemistry
Plant Extracts/isolation & purification
Plant Leaves/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antiprotozoal Agents); 0 (Coumarins); 0 (Plant Extracts); 0 (mammea A-BB); 588X2YUY0A (Methylene Chloride)
[Em] Entry month:1705
[Cu] Class update date: 170522
[Lr] Last revision date:170522
[Js] Journal subset:IM
[Da] Date of entry for processing:160526
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-107673

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[PMID]: 27907087
[Au] Autor:Rouger C; Pagie S; Derbré S; Le Ray AM; Richomme P; Charreau B
[Ad] Address:Université d'Angers, Campus du végétal, SFR4207 QUASAV, EA921 SONAS, Beaucouzé, France.
[Ti] Title:Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells.
[So] Source:PLoS One;11(12):e0167361, 2016.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Endothelial cells (ECs) are key players in inflammation and immune responses involved in numerous pathologies. Although attempts were experimentally undertaken to prevent and control EC activation, drug leads and probes still remain necessary. Natural products (NPs) from Clusiaceous and Calophyllaceous plants were previously reported as potential candidates to prevent endothelial dysfunction. The present study aimed to identify more precisely the molecular scaffolds that could limit EC activation. Here, 13 polyphenols belonging to 5 different chemical types of secondary metabolites (i.e., mammea coumarins, a biflavonoid, a pyranochromanone acid, a polyprenylated polycyclic acylphloroglucinol (PPAP) and two xanthones) were tested on resting and cytokine-activated EC cultures. Quantitative and qualitative changes in the expression of both adhesion molecules (VCAM-1, ICAM-1, E-selectin) and major histocompatibility complex (MHC) molecules have been used to measure their pharmaceutical potential. As a result, we identified 3 mammea coumarins that efficiently reduce (up to >90% at 10 µM) both basal and cytokine-regulated levels of MHC class I, class II, MICA and HLA-E on EC surface. They also prevented VCAM-1 induction upon inflammation. From a structural point of view, our results associate the loss of the free prenyl group substituting mammea coumarins with a reduced cellular cytotoxicity but also an abrogation of their anti-inflammatory potential and a reduction of their immunosuppressive effects. A PPAP, guttiferone J, also triggers a strong immunomodulation but restricted to HLA-E and MHC class II molecules. In conclusion, mammea coumarins with a free prenyl group and the PPAP guttiferone J emerge as NPs able to drastically decrease both VCAM-1 and a set of MHC molecules and to potentially reduce the immunogenicity of the endothelium.
[Mh] MeSH terms primary: Biological Products/pharmacology
Endothelial Cells/drug effects
Inflammation/drug therapy
Polyphenols/pharmacology
[Mh] MeSH terms secundary: Antigen Presentation/drug effects
Biological Products/chemistry
Clusiaceae/chemistry
Coumarins/pharmacology
Cytokines/biosynthesis
E-Selectin/biosynthesis
Endothelial Cells/pathology
Histocompatibility Antigens Class II/biosynthesis
Humans
Inflammation/genetics
Inflammation/pathology
Intercellular Adhesion Molecule-1/biosynthesis
Interferon-gamma/biosynthesis
Polyphenols/chemistry
Prenylation/drug effects
Tumor Necrosis Factor-alpha/biosynthesis
Vascular Cell Adhesion Molecule-1/biosynthesis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biological Products); 0 (Coumarins); 0 (Cytokines); 0 (E-Selectin); 0 (Histocompatibility Antigens Class II); 0 (Polyphenols); 0 (Tumor Necrosis Factor-alpha); 0 (Vascular Cell Adhesion Molecule-1); 126547-89-5 (Intercellular Adhesion Molecule-1); 82115-62-6 (Interferon-gamma)
[Em] Entry month:1707
[Cu] Class update date: 170703
[Lr] Last revision date:170703
[Js] Journal subset:IM
[Da] Date of entry for processing:161202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167361

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[PMID]: 27695262
[Au] Autor:Uto T; Tung NH; Thongjankaew P; Lhieochaiphant S; Shoyama Y
[Ad] Address:Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki 859-3298, Japan.
[Ti] Title:Kayeassamin A Isolated from the Flower of Triggers Apoptosis by Activating Caspase-3/-8 in HL-60 Human Leukemia Cells.
[So] Source:Pharmacognosy Res;8(4):244-248, 2016 Oct-Dec.
[Is] ISSN:0976-4836
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: (Miq.) T. Anders. is used as a medicinal plant in Thailand and has several traditional therapeutic properties. In a previous study, we isolated eight compounds from the flower of M. siamensis and demonstrated that kayeassamin A (KA) exhibited potent antiproliferative activity against human leukemia and stomach cancer cell lines. OBJECTIVE: In this study, we investigated the effect of KA on cell viability and apoptotic mechanisms in HL-60 human leukemia cells. MATERIALS AND METHODS: Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Nuclear morphology and DNA fragmentation were observed using Hoechst 33258 staining and agarose gel electrophoresis, respectively. The sub-G1 phase of cells was analyzed by flow cytometry after the cellular DNA had been stained with propidium iodide. The protein levels of poly (ADP-ribose) polymerase (PARP) and caspases were determined by Western blotting. RESULTS: KA exhibited a significant cytotoxic effect in a dose- and time-dependent manner, and induced chromatin condensation, DNA fragmentation, and sub-G1 phase DNA content, known as molecular events associated with the induction of apoptosis. In addition, KA strongly induced the activation of PARP and caspase-3 and -8, with weak caspase-9 activation. Furthermore, KA-induced DNA fragmentation was abolished by pretreatment with z-VAD-FMK (a broad caspase inhibitor), z-DEVD-FMK (a caspase-3 inhibitor), and z-IETD-FMK (a caspase-8 inhibitor), but not by z-LEHD-FMK (a caspase-9 inhibitor) pretreatment. CONCLUSION: These results indicate that KA triggers apoptotic cell death by activation of caspase-3 and -8 in HL-60 cells. SUMMARY: Kayeassamin A (KA) isolated from the flower of exhibited a significant cytotoxic effect in HL-60 human leukemia cells. KA triggers apoptotic cell death by activating caspase-3/-8. : KA: Kayeassamin A; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PARP: Poly (ADP-ribose) polymerase; PI: Propidium iodide; CA: Corosolic acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE

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[PMID]: 27373643
[Au] Autor:Ninomiya K; Shibatani K; Sueyoshi M; Chaipech S; Pongpiriyadacha Y; Hayakawa T; Muraoka O; Morikawa T
[Ad] Address:Pharmaceutical Research and Technology Institute, Kindai University.
[Ti] Title:Aromatase Inhibitory Activity of Geranylated Coumarins, Mammeasins C and D, Isolated from the Flowers of Mammea siamensis.
[So] Source:Chem Pharm Bull (Tokyo);64(7):880-5, 2016.
[Is] ISSN:1347-5223
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A methanol extract of the flowers of Mammea siamensis (Calophyllaceae) was found to inhibit enzymatic activity against aromatase (IC50=16.5 µg/mL). From the extract, two new geranylated coumarins, mammeasins C (1) and D (2), were isolated together with seven coumarins: 8-hydroxy-5-methyl-7-(3,7-dimethyl-octa-2,6-dienyl)-9-(2-methyl-1-oxobutyl)-4,5-dihydropyrano[4,3,2-de]chromen-2-one (9), 8-hydroxy-5-methyl-7-(3,7-dimethyl-octa-2,6-dienyl)-9-(3-methyl-1-oxobutyl)-4,5-dihydropyrano[4,3,2-de]chromen-2-one (10), mammeas A/AA (14), A/AB (15), A/AA cyclo D (18), E/BA (23), and E/BC cyclo D (25). The structures of 1 and 2 were elucidated on the basis of spectroscopic evidence. Among the isolates including 17 previously reported coumarins, 1 (IC50=2.7 µM), 2 (3.6 µM), and mammea B/AB cyclo D (21, 3.1 µM) showed relatively strong inhibitory activities comparable to the activity of the synthetic nonsteroidal aromatase inhibitor aminoglutethimide (2.0 µM).
[Mh] MeSH terms primary: Aromatase Inhibitors/pharmacology
Aromatase/metabolism
Coumarins/pharmacology
Flowers/chemistry
Mammea/chemistry
[Mh] MeSH terms secundary: Aromatase Inhibitors/chemistry
Aromatase Inhibitors/isolation & purification
Coumarins/chemistry
Coumarins/isolation & purification
Dose-Response Relationship, Drug
Humans
Molecular Structure
Recombinant Proteins/metabolism
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Aromatase Inhibitors); 0 (Coumarins); 0 (Recombinant Proteins); 0 (mammeasin C); 0 (mammeasin D); EC 1.14.14.1 (Aromatase)
[Em] Entry month:1701
[Cu] Class update date: 170126
[Lr] Last revision date:170126
[Js] Journal subset:IM
[Da] Date of entry for processing:160705
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c16-00218

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PubMed Central Full text

[PMID]: 27222838
[Au] Autor:Okokon JE; Bawo MB; Mbagwu HO
[Ad] Address:Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
[Ti] Title:Hepatoprotective activity of Mammea africana ethanol stem bark extract.
[So] Source:Avicenna J Phytomed;6(2):248-59, 2016 Mar-Apr.
[Is] ISSN:2228-7930
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol-induced liver injury in rats. MATERIALS AND METHODS: The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. RESULTS: Administration of the stem bark extract caused a significant (p<0.05 - 0.001) dose-dependent reduction of high levels of liver enzymes (ALT, AST and ALP), total cholesterol, direct and total bilirubin as well as elevation of serum levels of total protein, albumin and antioxidant enzymes (SOD, CAT, GPx and GSH). Histology of the liver sections of extract and silymarin-treated animals showed reductions in the pathological features compared to the paracetamol-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the stem bark extract of M. africana. CONCLUSION: The results show that the stem bark extract of M. africana has hepatoprotective potential which may be due to its antioxidant activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1605
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160526
[St] Status:PubMed-not-MEDLINE


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