Database : MEDLINE
Search on : Massive and Hepatic and Necrosis [Words]
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[PMID]: 29436798
[Au] Autor:Heidari A; Dabiri S; Sabzi F
[Ad] Address:Department of Anesthesiology, Kermanshah University of Sciences, Imam Ali Hospital, Kermanshah, Iran.
[Ti] Title:A Road to the Heart From Uterine Closet: A Case Report.
[So] Source:Acta Med Iran;56(1):67-70, 2018 Jan.
[Is] ISSN:1735-9694
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:Angiosarcomas of the uterine is a malignant and poor prognostic tumor and can either be a primary sarcoma or arising secondary to radiotherapy of a more complex tumor. Primary uterine angiosarcomas are exceptional and probably arise from embryonic vascular remnants, teratoma or from the rich uterine vasculature. We reported a rare case of primary angiosarcoma of uterine that at the time of diagnosis presented with sign and symptom of local and distant metastasis. The patient presented with dyspnea, chest pain, and history of vaginal bleeding and pelvic pain. The physical exam revealed pallor, prominent jugular pulse pressure, a palpable fixed mass in the pelvic however vaginal exam was unremarkable. Transthoracic echocardiography (TTE) revealed massive pericardial effusion and also a large mass in the right atrium. The abdominal ultrasound showed echogenic and poor echogenic segments in uterine mass combined with central necrosis. The patient underwent total hysterectomy and Bilateral salpingo-oophorectomy followed by radiotherapy and adjuvant chemotherapy. The patient underwent open heart surgery with resection of cardiac mass and further received a four cycle of radiotherapy (50 MG) to the mediastinum. The further follow-up (6 month) revealed no recurrence of tumor in a mediastinum. However, patient died from metastasis to the liver and its hepatic failure sequels.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process

  2 / 1024 MEDLINE  
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[PMID]: 29311434
[Au] Autor:Ozaki K; Hirabayashi M; Nomura K; Narama I
[Ad] Address:Laboratory of Pathology, Setsunan University.
[Ti] Title:Suspected lily toxicosis in a meerkat (Suricata suricatta): a case report.
[So] Source:J Vet Med Sci;, 2018 Jan 04.
[Is] ISSN:1347-7439
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Lilies are considered nephrotoxic only to domestic cats, which belong to the family Felidae of the suborder Feliformia. However, a 7-month-old female meerkat, belonging to the family Herpestidae of the suborder Feliformia, presented with oliguria, seizure, tachypnea, self-biting, and nystagmus after it ingested lilies. The meerkat died approximately 40 hr after lily ingestion. Gross and histopathologic lesions consistent with acute renal failure were conspicuous in the animal. The renal lesions were acute tubular necrosis, corresponding to the typical pathological changes of lily toxicosis in cats. In addition, massive hepatocyte necrosis and pulmonary congestion/oedema were observed. These findings suggest that lily toxicosis in meerkats is characterized by pulmonary and hepatic failure, in addition to the renal failure observed in domestic cats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:Publisher
[do] DOI:10.1292/jvms.17-0645

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[PMID]: 29113002
[Au] Autor:Thiel AM; Rissland J; Lammert F; Casper M
[Ad] Address:Klinik für Innere Medizin II, Universitätsklinikum des Saarlandes, Homburg, Germany.
[Ti] Title:Akutes Leberversagen als seltene Manifestation einer häufigen Erkrankung. [Acute liver failure as a rare case of a frequent disease].
[So] Source:Z Gastroenterol;, 2017 Nov 07.
[Is] ISSN:1439-7803
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Here we report the case of a 63-year-old female patient who was admitted with acute liver failure. The etiology turned out to be an acute fulminant hepatitis caused by hepatitis C virus (HCV) infection of unknown origin. Fulminant hepatitis due to acute hepatitis C is very rare and hardly reported but a potential cause of acute liver failure due to massive hepatic necrosis, which may lead to encephalitis and multi-organ-failure. During follow-up spontaneous virological clearance was observed. The case illustrates that acute HCV infection, which is confirmed by the detection of HCV-RNA, has to be considered in the differential diagnosis of acute liver failure.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher
[do] DOI:10.1055/s-0043-120925

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[PMID]: 29033683
[Au] Autor:Kotani K; Kawabe J; Higashiyama S; Shiomi S
[Ad] Address:Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
[Ti] Title:Regional Liver Disorder with Differences in the Accumulation of Tc-phytate and Tc-galactosyl Human Serum Albumin.
[So] Source:World J Nucl Med;16(4):320-323, 2017 Oct-Dec.
[Is] ISSN:1450-1147
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:We report a 56-year-old woman with regional liver disorder due to acute hepatitis. Computed tomographic images showed low signal density at a plain phase and prolonged contrast effect at a late phase in the left hepatic lobe, in which an accumulation of Tc-phytate increased, whereas that of Tc-galactosyl human serum albumin (GSA) decreased. Meanwhile, in the right lobe, an accumulation of Tc-GSA showed more increased than that of Tc-phytate. Liver biopsy showed massive hepatocyte necrosis and interface hepatitis in the left lobe, and moderate hepatitis in the right lobe. Differences in the accumulation between these scintigrams were helpful for understanding rapid necrosis in the left lobe, resulting in a compensatory enlargement of the right lobe. Clinicians should be aware that some cases of acute hepatitis cause regional liver disorder although most cases show homogeneous inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/1450-1147.215493

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[PMID]: 28923247
[Au] Autor:Chen YH; Chiu CC; Hung SW; Liu JY; Wang YC; Lv Q; Hsu CC; Huang YW; Huang WC; Chuang HL; Chen TH
[Ad] Address:Graduate Institute of Veterinary Pathobiology, National Chung Hsin University, Taichung 402, Taiwan.
[Ti] Title:Effects of plant- and animal-based high-fat diets on lipid storage and distribution in environmental bacteria-colonized gnotobiotic mice.
[So] Source:Biochem Biophys Res Commun;493(2):1075-1081, 2017 Nov 18.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Different edible oils such as lard and soybean oil have been reported to interact with the gut microbiota, affecting host lipid metabolism. However, whether bacteria derived from the environment influence host lipid metabolism remains unclear. This study aimed to clarify the roles of environmental bacteria in host lipid storage and distribution with various edible oils. Gnotobiotic C57BL/6JNarl mice were inoculated with Lysinibacillus xylanilyticus and Paenibacillus azoreducens and then fed either a normal diet (LabDiet 5010, control group) or a diet containing 60% lard (L-group) or soybean oil (S-group) for 18 months. Interestingly, the S-group accumulated massive amounts of white adipose tissue compared to the L- and control groups, while the L-group displayed more hepatic steatosis and fatty droplets than the other groups. The expression of fatty acid synthase (FAS), hydroxymethylglutaryl-coenzyme A reductase (HMGCR), sterol regulatory element-binding protein 2 (SREBP2), and peroxisome proliferator-activated receptor gamma (PPARγ) in the livers of the L-group were markedly elevated compared to the S-group. FAS and PPARγ protein levels were also markedly elevated. However, there were no differences in the expression of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α between the groups. Our results suggest that environmental bacteria may affect host hepatic inflammation and lipid distribution in the presence of high-fat diets, with different effects depending on the fat type consumed.
[Mh] MeSH terms primary: Diet, High-Fat/adverse effects
Fatty Liver/metabolism
Fatty Liver/microbiology
Lipid Metabolism
Liver/metabolism
Liver/microbiology
[Mh] MeSH terms secundary: Animals
Bacillaceae/physiology
Dietary Fats/adverse effects
Dietary Fats/metabolism
Fatty Liver/pathology
Liver/pathology
Male
Mice, Inbred C57BL
Paenibacillus/physiology
Soybean Oil/adverse effects
Soybean Oil/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Dietary Fats); 8001-22-7 (Soybean Oil); SI6O3IW77Z (lard)
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[Js] Journal subset:IM
[Da] Date of entry for processing:170920
[St] Status:MEDLINE

  6 / 1024 MEDLINE  
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[PMID]: 28915665
[Au] Autor:Vidali S; Aminzadeh-Gohari S; Feichtinger RG; Vatrinet R; Koller A; Locker F; Rutherford T; O'Donnell M; Stöger-Kleiber A; Lambert B; Felder TK; Sperl W; Kofler B
[Ad] Address:Laura Bassi Centre of Expertise-THERAPEP, Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria.
[Ti] Title:The ketogenic diet is not feasible as a therapy in a CD-1 nu/nu mouse model of renal cell carcinoma with features of Stauffer's syndrome.
[So] Source:Oncotarget;8(34):57201-57215, 2017 Aug 22.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The ketogenic diet (KD), a high-fat low-carbohydrate diet, has shown some efficacy in the treatment of certain types of tumors such as brain tumors and neuroblastoma. These tumors are characterized by the Warburg effect. Because renal cell carcinoma (RCC) presents similar energetic features as neuroblastoma, KD might also be effective in the treatment of RCC. To test this, we established xenografts with RCC 786-O cells in CD-1 nu/nu mice and then randomized them to a control diet or to KDs with different triglyceride contents. Although the KDs tended to reduce tumor growth, mouse survival was dramatically reduced due to massive weight loss. A possible explanation comes from observations of human RCC patients, who often experience secondary non-metastatic hepatic dysfunction due to secretion of high levels of inflammatory cytokines by the RCCs. Measurement of the mRNA levels of tumor necrosis factor alpha (TNFα) and interleukin-6 revealed high expression in the RCC xenografts compared to the original 786-O cells. The expression of TNFα, interleukin-6 and C-reactive protein were all increased in the livers of tumor-bearing mice, and KD significantly boosted their expression. KDs did not cause weight loss or liver inflammation in healthy mice, suggesting that KDs are per se safe, but might be contraindicated in the treatment of RCC patients presenting with Stauffer's syndrome, because they potentially worsen the associated hepatic dysfunction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170925
[Lr] Last revision date:170925
[Da] Date of entry for processing:170917
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.18632/oncotarget.19306

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[PMID]: 28914695
[Au] Autor:Jain V; Srivastava A; Yachha SK; Kumari N; Kathuria R; Sarma MS; Poddar U; Krishnani N
[Ad] Address:Departments of aPediatric Gastroenterology bPathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
[Ti] Title:Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease?
[So] Source:Eur J Gastroenterol Hepatol;29(12):1408-1415, 2017 Dec.
[Is] ISSN:1473-5687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Presentation as autoimmune acute liver failure (AI-ALF) and seronegative autoimmune liver disease (SN-AILD) represents two uncommon variants of AILD. We compared the clinical profile and outcome of AI-ALF with autoimmune-non-acute liver failure (AI-non-ALF) and also SN-AILD with seropositive autoimmune liver disease (SP-AILD). MATERIALS AND METHODS: Children managed as AI-ALF and AI-non-ALF including SN-AILD and SP-AILD were enrolled and compared. AI-non-ALF was diagnosed by simplified diagnostic criteria and AI-ALF by Pediatric Acute Liver Failure Study Group criteria with positive autoantibody, exclusion of other etiologies, elevated immunoglobulin G and histology when available. RESULTS: Seventy children [AI-ALF=15 and AI-non-ALF=55 (SN-AILD=11, SP-AILD=44)] were evaluated. Age at presentation [7 (1.2-16) vs. 9 (2-17) years] percentage of female patients (67 vs. 62%), and AILD type (type II, 53 vs. 31%) were similar in AI-ALF and AI-non-ALF patients], respectively. 8/15 AI-ALF cases were treated with steroids (improved-4, liver transplant-1, and death-3) and 7/15 died before initiation of therapy. Hepatic encephalopathy (100 vs. 16.3%; P<0.001), massive hepatic necrosis (60 vs. 0%; P<0.001), and higher pediatric end-stage liver disease [n=53, 29.9 (13.1-56.9) vs. 9.8 (-10-28.7) P<0.001], model for end-stage liver disease [n=17, 38.5 (24-46) vs. 18 (6-24); P=0.005], and Child-Turcotte-Pugh [n=70, 13 (8-13) vs. 9 (5-13); P<0.001] scores were features of AI-ALF. Poorer response to immunosuppression (4/8 vs. 48/55; P=0.02) and higher mortality (11/15 vs. 4/55; P=0.0001) were seen in AI-ALF than in AI-non-ALF patients. Clinicolaboratory profile, therapeutic response, and outcome were similar in SN-AILD and SP-AILD. CONCLUSION: AI-ALF is characterized by poorer liver function, lower response to immunosuppression, and higher mortality compared with SP or SN AI-non-ALF, which are similar.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:In-Process
[do] DOI:10.1097/MEG.0000000000000975

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[PMID]: 28871276
[Au] Autor:Leiner M; De la Vega I; Johansson B
[Ad] Address:Pediatrics, Texas Tech University Health Sciences Center, El Paso, TX, United States.
[Ti] Title:Fear of Massive Deportations in the United States: Social Implications on Deprived Pediatric Communities.
[So] Source:Front Pediatr;5:177, 2017.
[Is] ISSN:2296-2360
[Cp] Country of publication:Switzerland
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170907
[Lr] Last revision date:170907
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fped.2017.00177

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[PMID]: 28870676
[Au] Autor:Kron P; Schlegel A; Mancina L; Clavien PA; Dutkowski P
[Ad] Address:Department of Surgery & Transplantation, University Hospital Zurich, Switzerland.
[Ti] Title:Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans.
[So] Source:J Hepatol;, 2017 Sep 21.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: Pretreatment of marginal organs by perfusion is a promising opportunity to make more organs available for transplantation. Protection of human donation after cardiac death (DCD) livers by a novel machine perfusion technique, hypothermic oxygenated perfusion (HOPE), was recently established. Herein, we tested whether HOPE is also useful for fatty liver grafts, using a rodent transplant model. METHODS: Rats were fed over three weeks with a special methionine-choline-deficient diet (MCDD) to induce severe hepatic macrosteatosis (≥60%). Afterwards, livers were transplanted with either minimal or 12h cold storage. Additional liver grafts were treated after 12h cold storage with 1h HOPE before transplantation. Graft injury after orthotopic liver transplantation (OLT) was assessed in terms of oxidative stress, damage-associated molecular patterns release, toll-like receptor-4 activation, cytokine release, endothelial activation, and the development of necrosis and fibrosis. RESULTS: Implantation of cold stored macrosteatotic liver grafts induced massive reperfusion injury after OLT, compared to controls (non-fatty livers). HOPE treatment after cold storage failed to change the degree of steatosis itself, but markedly decreased reperfusion injury after OLT, as detected by less oxidative stress, less nuclear injury, less Kupffer- and endothelial cell activation, as well as less fibrosis within one week after OLT. Protective effects were lost in the absence of oxygen in the HOPE perfusate. CONCLUSION: HOPE after cold storage of fatty livers prevents significant reperfusion injury and improves graft function, comparable to the effects of HOPE in DCD livers and DCD kidneys. HOPE treatment is easy and may become a universal concept to further expand the donor pool. LAY SUMMARY: An increasing number of donor livers contain fat. It is important to harness marginal livers, which may contain fat, as the stock of donor livers is limited. Hypothermic oxygenated perfusion (HOPE) prevents reperfusion injury and improves liver graft function. HOPE offers a simple and low-cost option for treating liver grafts in transplant centers, even after cold storage, instead of transporting machines to the place of procurement. HOPE could be used globally to expand the donor pool.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:Publisher

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[PMID]: 28782260
[Au] Autor:George J; Tsutsumi M; Tsuchishima M
[Ad] Address:Department of Medicine, Division of Molecular Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
[Ti] Title:MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice.
[So] Source:J Cell Mol Med;, 2017 Aug 07.
[Is] ISSN:1582-4934
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Connective tissue growth factor (CTGF) is involved in inflammation, pathogenesis and progression of liver fibrosis. Matrix metalloproteinase-13 (MMP-13) cleaves CTGF and releases several fragments, which are more potent than the parent molecule to induce fibrosis. The current study was aimed to elucidate the significance of MMP-13 and CTGF and their downstream effects in liver injury and fibrosis. Hepatic fibrosis was induced using intraperitoneal injections of N-nitrosodimethylamine (NDMA) in doses of 10 µg/g body weight on three consecutive days of each week over a period of 4 weeks in both wild-type (WT) and MMP-13 knockout mice. Administration of NDMA resulted in marked elevation of AST, ALT, TGF-ß1 and hyaluronic acid in the serum and activation of stellate cells, massive necrosis, deposition of collagen fibres and increase in total collagen in the liver of WT mice with a significant decrease in MMP-13 knockout mice. Protein and mRNA levels of CTGF, TGF-ß1, α-SMA and type I collagen and the levels of MMP-2, MMP-9 and cleaved products of CTGF were markedly increased in NDMA-treated WT mice compared to the MMP-13 knockout mice. Blocking of MMP-13 with CL-82198 in hepatic stellate cell cultures resulted in marked decrease of the staining intensity of CTGF as well as protein levels of full-length CTGF and its C-terminal fragments and active TGF-ß1. The data demonstrate that MMP-13 and CTGF play a crucial role in modulation of fibrogenic mediators and promote hepatic fibrogenesis. Furthermore, the study suggests that blocking of MMP-13 and CTGF has potential therapeutic implications to arrest liver fibrosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170807
[Lr] Last revision date:170807
[St] Status:Publisher
[do] DOI:10.1111/jcmm.13304


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