Database : MEDLINE
Search on : Medullary and Sponge and Kidney [Words]
References found : 492 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 50 go to page                         

  1 / 492 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29468561
[Au] Autor:Gambaro G; Goldfarb DS; Baccaro R; Hirsch J; Topilow N; D'Alonzo S; Gambassi G; Ferraro PM
[Ad] Address:Divisione di Nefrologia, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Via G. Moscati 31, 00168, Rome, Italy.
[Ti] Title:Chronic pain in medullary sponge kidney: a rare and never described clinical presentation.
[So] Source:J Nephrol;, 2018 Feb 21.
[Is] ISSN:1724-6059
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK-CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires. Ninety-two patients with a diagnosis of MSK joined our survey. Stone rate was very high (3.1 stones per patient-year, < 15% of patients had ≤ 1 stone per year). Most patients had repeated hospitalizations for stones symptoms (p < 0.001) or pain (p < 0.005). 71% of participants referred a daily pain that interfered strongly with everyday life and quality of life (WQL mean value 29.4). 69% used pain medications daily (70% opioids). In most cases, pain was associated with stone passage, while 15% referred a sine materia pain. We showed how MSK-CP symptoms affect very negatively on the quality of life of these patients. They also have a definite risk of progressing to end-stage kidney disease. Generally, CP seems to be associated with an exceptionally high lithogenic activity, suggesting that a better and earlier metabolic treatment for stone prevention should be the first approach in these patients before mini-invasive treatments to prevent pain.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1007/s40620-018-0480-8

  2 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29198009
[Au] Autor:Giambelluca D; Caruana G; Giambelluca E; Picone D; Lo Re G
[Ad] Address:Section of Radiological Sciences, Di.Bi.Med, University of Palermo, Via del Vespro 127, 90127, Palermo, Italy. dariojambo@hotmail.it.
[Ti] Title:The "bouquet of flowers" appearance in medullary sponge kidney.
[So] Source:Abdom Radiol (NY);, 2017 Dec 02.
[Is] ISSN:2366-0058
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 171203
[Lr] Last revision date:171203
[St] Status:Publisher
[do] DOI:10.1007/s00261-017-1420-0

  3 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29050173
[Au] Autor:Hong Y; Xu QQ; Huang XB; Zhu ZJ; Ye HY; Zhang FS; Yang QY; An LZ; Xu T
[Ad] Address:Department of Urology, Peking University People's Hospital, Beijing 100034, China.
[Ti] Title:[Effects of percutaneous nephrolithotomy in the treatment of medullary sponge kidney with calculi].
[So] Source:Zhonghua Wai Ke Za Zhi;55(10):742-745, 2017 Oct 01.
[Is] ISSN:0529-5815
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To evaluate the effects of percutaneous nephrolithotomy (PNL) in the treatment of medullary sponge kidney with calculi. A total of 77 patients (91 renal units) of medullary sponge kidney with calculi (MSK group) and 77 patients (77 renal units) with common kidney stone (control group) received PNL at Department of Urology in Peking University People's Hospital from September 2006 to February 2016 were analyzed retrospectively. The MSK group included 33 males and 44 females with a mean age of (42.1±13.2) years, the mean stone burden was (3.9±1.8) cm. The control group included 36 males and 41 females with a mean age of (45.3±13.0) years, the mean stone burden was (3.6±1.5) cm. The numbers of tracts, the time of operation, the drop of hemoglobin, the change of creatine, the time of hospitalization, the stone free rate and major complications were compared between the two groups. The measurement data and numeration data were compared with test and χ(2) test. There were no significant differences in sex, age, preoperative urinary tract infection, stone type, and stone burden between the two groups (all >0.05). The proportion of bilateral renal calculus in MSK group was higher (18.2% . 0, χ(2)=15.400, =0.000). There were 159 percutaneous channels were established in MSK group while 90 percutaneous channels were established in control group. Compared with the control group, the operation time ((88.1±37.5) minutes . (68.5±30.1) minutes, =3.543, =0.000) and hospitalization time ((15.1±8.3) days . (10.1±3.6) days, =4.816, =0.000) were longer, the creatinine level increased ((101.2±62.6) µmol/L . (71.3±23.6) µmol/L, =3.777, =0.000), the rate of stone free decreased (27.5% . 83.1%, χ(2)=51.840, =0.000) and the rate of complications increased (29.9% . 11.7%, χ(2)=8.114, =0.004) in MSK group. There was no statistically difference in hemoglobin drop ((12.5±13.2) g/L . (13.0±10.9) g/L, =-0.260, =0.795). Using PNL for patients of MSK with calculi has a lower stone free rate and a higher complications. It is an effective method for patients of MSK with large and complex calculi.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0529-5815.2017.10.005

  4 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28595282
[Au] Autor:Irazusta FJ; Caro-Codón J; Merás P; Torres MI; Refoyo-Salicio E
[Ad] Address:Department of Cardiology, University Hospital La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain.
[Ti] Title:A giant septal diverticulum in a patient with medullary sponge kidney.
[So] Source:Eur Heart J Cardiovasc Imaging;18(10):1189, 2017 Oct 01.
[Is] ISSN:2047-2412
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[St] Status:In-Data-Review
[do] DOI:10.1093/ehjci/jex142

  5 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28479783
[Au] Autor:Cheungpasitporn W; Pawar AS; Erickson SB
[Ad] Address:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
[Ti] Title:Recurrent renal calculi in coexistence of horseshoe kidney and medullary sponge kidney.
[So] Source:Urol Ann;9(2):214-215, 2017 Apr-Jun.
[Is] ISSN:0974-7796
[Cp] Country of publication:India
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/UA.UA_173_16

  6 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28087010
[Au] Autor:Chutipongtanate S
[Ad] Address:Pediatric Translational Research Unit, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand. Electronic address: schuti.rama@gmail.com.
[Ti] Title:Breaking the ice: urine proteomics of medullary sponge kidney disease.
[So] Source:Kidney Int;91(2):281-283, 2017 Feb.
[Is] ISSN:1523-1755
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. This commentary discusses several considerations in biomarker validation, and how urinary proteomics breaks new ground in MSK research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 170114
[Lr] Last revision date:170114
[St] Status:In-Process

  7 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27914711
[Au] Autor:Fabris A; Bruschi M; Santucci L; Candiano G; Granata S; Dalla Gassa A; Antonucci N; Petretto A; Ghiggeri GM; Gambaro G; Lupo A; Zaza G
[Ad] Address:Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.
[Ti] Title:Proteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease.
[So] Source:Kidney Int;91(2):459-468, 2017 Feb.
[Is] ISSN:1523-1755
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identify such we employed a proteomic-based research strategy utilizing urine from 22 patients with MSK and 22 patients affected by idiopathic calcium nephrolithiasis (ICN) as controls. Notably, two patients with ICN presented cysts. In the discovery phase, the urine of 11 MSK and 10 controls, were randomly selected, processed, and analyzed by mass spectrometry. Subsequently, several statistical algorithms were undertaken to select the most discriminative proteins between the two study groups. ELISA, performed on the entire patients' cohort, was used to validate the proteomic results. After an initial statistical analysis, 249 and 396 proteins were identified exclusive for ICN and MSK, respectively. A Volcano plot and ROC analysis, performed to restrict the number of MSK-associated proteins, indicated that 328 and 44 proteins, respectively, were specific for MSK. Interestingly, 119 proteins were found to differentiate patients with cysts (all patients with MSK and the two ICN with renal cysts) from ICN without cysts. Eventually, 16 proteins were found to be common to three statistical methods with laminin subunit alpha 2 (LAMA-2) reaching the higher rank by a Support Vector Machine, a binary classification/prediction scheme. ELISA for LAMA-2 validated proteomic results. Thus, using high-throughput technology, our study identified a candidate MSK biomarker possibly employable in future for the early diagnosis of this disease.
[Mh] MeSH terms primary: High-Throughput Screening Assays
Laminin/urine
Medullary Sponge Kidney/urine
Proteomics/methods
[Mh] MeSH terms secundary: Algorithms
Area Under Curve
Biomarkers/urine
Case-Control Studies
Cluster Analysis
Discriminant Analysis
Early Diagnosis
Enzyme-Linked Immunosorbent Assay
Humans
Medullary Sponge Kidney/diagnosis
Predictive Value of Tests
ROC Curve
Reproducibility of Results
Support Vector Machine
Tandem Mass Spectrometry
Urinalysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 0 (Laminin); 0 (laminin alpha 2)
[Em] Entry month:1711
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[Js] Journal subset:IM
[Da] Date of entry for processing:161205
[St] Status:MEDLINE

  8 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27573101
[Au] Autor:Ria P; Fabris A; Dalla Gassa A; Zaza G; Lupo A; Gambaro G
[Ad] Address:Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy. ria.paolo@gmail.com.
[Ti] Title:New non-renal congenital disorders associated with medullary sponge kidney (MSK) support the pathogenic role of GDNF and point to the diagnosis of MSK in recurrent stone formers.
[So] Source:Urolithiasis;45(4):359-362, 2017 Aug.
[Is] ISSN:2194-7236
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Medullary sponge kidney (MSK) is a congenital renal disorder. Its association with several developmental abnormalities in other organs hints at the likelihood of some shared step(s) in the embryogenesis of the kidney and other organs. It has been suggested that the REarranged during Transfection (RET) proto-oncogene and the Glial cell line-Derived Neurotrophic Factor (GDNF) gene are defective in patients with MSK, and both RET and GDNF are known to have a role in the development of the central nervous system, heart, and craniofacial skeleton. Among a cohort of 143 MSK patients being followed up for nephrolithiasis and chronic kidney disease at our institution, we found six with one or more associated non-renal anomalies: one patient probably has congenital hemihyperplasia and hypertrophic cardiomyopathy with adipose metaplasia and mitral valve prolapse; one has Marfan syndrome; and the other four have novel associations between MSK and nerve and skeleton abnormalities described here for the first time. The discovery of disorders involving the central nervous system, cardiovascular system and craniofacial skeleton in MSK patients supports the hypothesis of a genetic alteration on the RET-GDNF axis having a pivotal role in the pathogenesis of MSK, in a subset of patients at least. MSK seems more and more to be a systemic disease, and the identification of extrarenal developmental defects could be important in arousing the suspicion of MSK in recurrent stone formers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1608
[Cu] Class update date: 170718
[Lr] Last revision date:170718
[St] Status:In-Process
[do] DOI:10.1007/s00240-016-0913-6

  9 / 492 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27994868
[Au] Autor:Cheungpasitporn W; Thongprayoon C; Brabec BA; Kittanamongkolchai W; Erickson SB
[Ad] Address:Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
[Ti] Title:Outcomes of living kidney donors with medullary sponge kidney.
[So] Source:Clin Kidney J;9(6):866-870, 2016 Dec.
[Is] ISSN:2048-8505
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Patients with medullary sponge kidney (MSK) commonly encounter recurrent nephrolithiasis. The existing knowledge on safety of donors with MSK has not been studied. METHODS: We conducted a retrospective cohort study at a tertiary referral hospital to assess the outcomes of living kidney donors with MSK. All adults with MSK ( = 26) who underwent nephrectomy as living kidney donors between January 2000 and September 2014 were included. Non-donors with MSK ( = 78) were randomly selected by matching the year of birth and the comorbidity score with a ratio of 1:3 for comparison. RESULTS: The incident rates of symptomatic stone were 0.7, 0.4 and 4.9 events/100 patient-years in donors, recipients and non-donors, respectively. After adjusting for history of kidney stones and baseline estimated glomerular filtration rate (eGFR), the kidney stone-related event was significantly lower in donors than in non-donors (hazard ratio 0.14; 95% confidence interval 0.01-0.66). One recipient of MSK living donor had symptomatic stone at median follow-up time of 8.4 years (interquartile range 5.6-12.4 years). None of MSK donors had hypercalciuria, hypocitraturia or hyperoxaluria prior to kidney donation. At 5 years after the index surgery date, there was no significant difference in eGFR between donors and non-donors (76.1 versus 70.9 mL/min/1.73 m , P = 0.12). CONCLUSIONS: These findings are reassuring for the safety of MSK kidney donors with normal kidney function, low kidney stone risk and no significant comorbidity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[St] Status:PubMed-not-MEDLINE

  10 / 492 MEDLINE  
              first record previous record
select
to print
Photocopy

[PMID]: 27441596
[Au] Autor:Marien TP; Miller NL
[Ad] Address:Department of Urologic Surgery, Vanderbilt Medical Center, Nashville, TN, USA - nicole.miller@vanderbilt.edu.
[Ti] Title:Characteristics of renal papillae in kidney stone formers.
[So] Source:Minerva Urol Nefrol;68(6):496-515, 2016 Dec.
[Is] ISSN:1827-1758
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:The mechanism of kidney stone formation is not well understood. In order to better understand the pathophysiology for specific kidney stone compositions and systemic diseases associated with kidney stones, endoscopic papillary mapping studies with concurrent biopsies have been conducted. This review will summarize the findings of these studies and proposed mechanisms for thirteen disease processes associated with kidney stones. A review of the literature was performed identifying thirteen studies that endoscopically mapped and biopsied renal papillae of different stone formers. These studies characterized renal papillae based on amount of Randall's plaque, Bellini's duct pathology, papillary contour changes, presence of attached stones, pitting, and frequently papillary and cortical biopsies. The groups studied and reviewed here are kidney stone formers who have a history of idiopathic calcium oxalate stone formation, cystinuria, brushite stones, gastric bypass, ileostomy, small bowel resection, primary hyperparathyroidism, distal renal tubular acidosis (dRTA), primary hyperoxaluria, idiopathic calcium phosphate stone formation, medullary sponge kidney (MSK), uric acid stones, and struvite stones. A proposed standardized scoring system for papillary pathology was also reviewed. The series showed various degrees and types of changes to the renal papillae and corresponding histopathologic changes for each type of stone former reviewed. Those with predominantly alone Randall's plaque pathology had less tissue damage versus those with extensive Bellini's duct lesions who had more interstitial fibrosis and cortical pathology. Randall's plaques are associated with stone formers who have low urinary volume, high urinary calcium, and acidic urine and thus are frequently seen in those with brushite stones, primary hyperparathyroidism, small bowel resection, and idiopathic calcium phosphate stone formers. Bellini's duct plugging and pathology is theorized to occur via free solution crystallization, ductal obstruction, inflammation, cellular injury, fibrosis, and acidification defects. Ureteroscopic manifestations of stone disease can vary from normal appearing papillae to significantly diseased appearing papillae. Some diseases have very characteristic papillary changes. Further studies are necessary to fully elucidate the mechanisms of stone formation in patients with nephrolithiasis.
[Mh] MeSH terms primary: Kidney Calculi/pathology
Kidney Medulla/pathology
[Mh] MeSH terms secundary: Humans
Kidney Calculi/etiology
Kidney Calculi/therapy
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170911
[Lr] Last revision date:170911
[Js] Journal subset:IM
[Da] Date of entry for processing:160722
[St] Status:MEDLINE


page 1 of 50 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information