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[PMID]: 29393460
[Au] Autor:Liu X; Yin S; Chen Y; Wu Y; Zheng W; Dong H; Bai Y; Qin Y; Li J; Feng S; Zhao P
[Ad] Address:Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China.
[Ti] Title:LPS­induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF­κB, STAT3 or AP­1 activation.
[So] Source:Mol Med Rep;17(4):5484-5491, 2018 Apr.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative bacteria, is one of the main etiological factors in the pathogenesis of several lung diseases, such as chronic obstructive pulmonary disease. The respiratory epithelium and the macrophages comprise the dynamic interface between the outside environment and the host response to bacterial infection via cytokine secretion. In the present study, the mechanisms of LPS induced­inflammatory response in human lung cells and macrophages were investigated. The effects of LPS exposure on cytokine production, inflammation­related transcription factors and intracellular signaling pathway activation were assessed in human lung mucoepidermoid carcinoma H292 cells and human macrophage THP­1 cells. The results demonstrated that LPS markedly increased the expression of interleukin (IL)­6, IL­8, tumor necrosis factor (TNF)­α, matrix metallopeptidase (MMP)­9 and tissue inhibitor of metalloproteinases­1 in H292 cells, while it increased the production of IL­6, IL­8 and TNF­α in differentiated THP­1 cells. In addition, LPS exposure activated nuclear factor (NF)­κB and activator protein (AP)­1 signaling in H292 cells, while it activated NF­κB and signal transducer and activator of transcription (STAT) 3 signaling in THP­1 cells. Furthermore, treatment with NF­κB, AP­1 or STAT3 inhibitors significantly decreased the LPS­mediated expression of IL­8 and TNF­α in these cells, suggesting that these pathways might serve crucial roles in LPS­induced cytokine expression. In conclusion, LPS stimulation of H292 and THP­1 cells induced cytokine expression and NF­κB, mitogen­activated protein kinase and Janus kinase/STAT3 pathway activation with subsequent nuclear translocation of NF­κB, AP­1 and STAT3, which demonstrated potential of the use of NF­κB, AP­1 and STAT3 in therapies for conditions and diseases associated with chronic inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8542

  2 / 2417 MEDLINE  
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[PMID]: 29494398
[Au] Autor:Franchi A; Taverna C; Simoni A; Pepi M; Mannelli G; Fasolati M; Gallo O
[Ad] Address:Section of Anatomic Pathology.
[Ti] Title:RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
[So] Source:Appl Immunohistochem Mol Morphol;, 2018 Feb 28.
[Is] ISSN:1533-4058
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic parameters. Formalin-fixed paraffin-embedded tumor samples from 46 consecutive cases of parotid gland carcinoma were selected for this study. For comparison, we examined a group of 40 randomly chosen parotid gland adenomas, including 20 pleomorphic adenomas, 10 myoepitheliomas, and 10 Warthin tumors. Immunohistochemical analysis for RANK and RANKL was conducted on tissue microarrays. Overall, 33 carcinomas (71.7%) were scored as positive for RANK and 25 (54.3%) for RANKL. The expression of both RANK and RANKL was significantly higher in carcinomas than in adenomas as only 6 (15%) adenomas were positive for RANK, and RANKL was negative in all benign tumors (P<0.001 for both, Fisher exact test). Some histologic types, including salivary duct carcinoma, mucoepidermoid carcinoma, and carcinoma ex-pleomorphic adenoma presented a high frequency of RANK and RANKL expression. No significant correlation was observed between RANK/RANKL expression and clinical parameters. Our study indicates that the expression of RANK and RANKL in parotid gland neoplasms is associated with the acquisition of a malignant phenotype and this pathway may represent an attractive therapeutic target in patients with parotid gland carcinomas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1097/PAI.0000000000000465

  3 / 2417 MEDLINE  
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[PMID]: 29493851
[Au] Autor:Hayashi K; Koto M; Demizu Y; Saitoh JI; Suefuji H; Okimoto T; Ohno T; Shioyama Y; Takagi R; Ikawa H; Nemoto K; Nakano T; Kamada T; Japan Carbon-Ion Radiation Oncology Study Group
[Ad] Address:Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
[Ti] Title:A retrospective multicenter study of carbon-ion radiotherapy for major salivary gland carcinomas: subanalysis of J-CROS 1402 HN.
[So] Source:Cancer Sci;, 2018 Mar 01.
[Is] ISSN:1349-7006
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A retrospective multicenter study was conducted to assess the clinical outcomes of carbon-ion radiotherapy for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We evaluated the safety and efficacy of carbon-ion radiotherapy in patients with major salivary gland carcinoma. Sixty-nine patients treated with carbon-ion radiotherapy at 4 Japanese institutions were analyzed. Thirty-three patients (48%) had adenoid cystic carcinomas, 10 (14%) had mucoepidermoid carcinomas, and 26 (38%) had other disease types. Three patients (4%) had T1 disease, 8 (12%) had T2, 25 (36%) had T3, and 33 (48%) had T4. The median radiation dose was 64 Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 27 mL. The median follow-up period was 32.7 months. The 3-year local control rate and overall survival rate were 81% and 94%, respectively. Regarding acute toxicities, 7 patients had grade 3 mucositis and 7 had grade 3 dermatitis. Regarding late toxicities, 1 patient had grade 3 dysphagia and 1 had a grade 3 brain abscess. No grade 4 or worse late reactions were observed. In conclusion, definitive carbon-ion radiotherapy was effective with acceptable toxicity for major salivary gland carcinomas. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1111/cas.13558

  4 / 2417 MEDLINE  
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[PMID]: 29486180
[Au] Autor:Resio BJ; Chiu AS; Hoag J; Dhanasopon AP; Blasberg JD; Boffa DJ
[Ad] Address:Section of Thoracic Surgery, Department of Surgery, Yale School of Medicine, 330 Cedar St. BB205, PO Box 208062, New Haven, CT 06520-8062.
[Ti] Title:Primary Salivary Type Lung Cancers in the National Cancer Database.
[So] Source:Ann Thorac Surg;, 2018 Feb 24.
[Is] ISSN:1552-6259
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Primary Salivary Type Lung Cancers (PSTLC) such as Adenoid Cystic Carcinoma (ACC) and Mucoepidermoid Carcinoma (MEC) are uncommon primary lung tumors that given their rarity, remain incompletely understood. This study aimed to characterize the management and outcomes associated with these less common pulmonary malignancies. METHODS: Patients in the National Cancer Database (NCDB) diagnosed with primary lung and bronchial (not tracheal) MEC and ACC between 2004-2014 were identified. Adjusted mortality risk of surgically- managed patients was evaluated in multivariable Cox proportional hazards regression models. RESULTS: A total of 699 MEC and 424 ACC patients were identified. MEC tumors were smaller (mean size 3.1cm vs. 3.8cm , P < .001), less likely to have lymph node metastases (16%, vs 38% P < .001) and less likely to undergo pneumonectomy (9% vs. 39% P<.001) compared to ACC. Adjusted Cox models of the surgically-managed subset of MEC identified high tumor grade (HR 3.0, 95% CI [1.31-7.1], p=0.01), tumor size >4cm (HR 6.7, 95% CI [2.0-22.0] p=0.01), and wedge resection (HR 3.7, 95% CI [1.1-12.0], p=0.03) to be associated with increased risk of death. For ACC, incomplete tumor resection (R1 vs. R0) (HR 4.0, 95% CI [1.5-10.6] p=0.006) and distant metastases (HR 12.6, 95% CI [2.5-64.4], p=0.002) were associated with increased mortality. CONCLUSIONS: Pulmonary MEC and ACC appear to have distinct physical and oncologic attributes in the NCDB. Although the overall prognosis appears to be favorable, there are subsets of PSTLC with increased mortality risk and efforts should be made to completely resect these tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher

  5 / 2417 MEDLINE  
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[PMID]: 29479842
[Au] Autor:Ames E; Campbell MJ; Afify A; Krane JF; Huang EC
[Ad] Address:Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
[Ti] Title:Sclerosing mucoepidermoid carcinoma with eosinophilia: Cytologic characterization of a rare distinct entity in the thyroid.
[So] Source:Diagn Cytopathol;, 2018 Feb 26.
[Is] ISSN:1097-0339
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an extremely rare thyroid carcinoma with limited cytologic descriptions in the literature. Here, we present a 52-year-old woman with a 3.9 cm thyroid nodule. Fine-needle aspiration smears consisted of a highly cellular specimen with tumor cells in isolated patterns and solid squamoid nests. Tumor cells had round to oval nuclei, prominent nucleoli, smooth nuclear contours, and moderate amounts of dense cytoplasm. In addition to the polymorphous population of lymphocytes, the background contained a striking abundance of eosinophils. The subsequent right thyroidectomy showed histologic features diagnostic for SMECE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1002/dc.23914

  6 / 2417 MEDLINE  
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[PMID]: 29461375
[Au] Autor:Ata N; Ünverdi H
[Ad] Address:Department of Otorhinolaryngology, Gaziantep 25 Aralik State Hospital.
[Ti] Title:Parotid Mucoepidermoid Carcinoma Mimicking a Large Mucocele.
[So] Source:J Craniofac Surg;, 2018 Feb 14.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mucoepidermoid carcinoma is a malign tumor involving the parotid gland and minor salivary glands. Parotid pure cystic mucoepidermoid carcinoma can also masquerade mucocele, and hence, histopathological examination is crucial to distinguish the 2. Herein, the authors report a patient of mucoepidermoid carcinoma presenting as an asymptomatic mucocele-like cystic parotid mass. A 69-year-old female presented with cystic parotid mass; her examination findings and diagnostic imaging were consistent with that of mucocele. Histological examination revealed mucoepidermoid carcinoma. This case indicates that parotid mucocele-like cysts should be included in the differential diagnosis of malign salivary gland tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1097/SCS.0000000000004329

  7 / 2417 MEDLINE  
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[PMID]: 29390541
[Au] Autor:Cheng M; Geng C; Tang T; Song Z
[Ad] Address:Institution: Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei province, P.R. China.
[Ti] Title:Mucoepidermoid carcinoma of the breast: Four case reports and review of the literature.
[So] Source:Medicine (Baltimore);96(51):e9385, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Mucoepidermoid carcinoma (MEC) of the breast is a rare entity comprising specific morphological and immunohistochemical features, and has been previously only reported in 33 cases. PATIENT CONCERNS: Four cases of MEC of the breast are reported in this study. All patients were women with ages ranging from 39 to 66 years. The lesions consisted of neoplastic solid nests and cystic spaces sometimes filled with mucoid material. DIAGNOSES: At high power, the tumors were composed of various proportions of basaloid, intermediate, epidermoid, and mucinous cells in different cases. All cases were classified as low-grade MEC of the breast. Tumor cells exhibited low levels of hormonal receptor expression in two cases (cases 1 and 3), and immunonegativity in one case (case 2). On the contrary, estrogen receptors (ER) were positively expressed in 60% of tumor cells in case 4. Tumor cells did not express human epidermal growth factor receptor 2 (HER-2)/neu protein in all the cases. INTERVENTIONS: Modified radical mastectomy (Auchincloss) was performed in the first two cases, while the remaining two patients underwent mastectomy plus sentinel lymph node biopsy. OUTCOMES: All patients were alive and well without evidence of recurrent disease after a period ranging from 4 months to 156 months. LESSONS: MEC of the breast is a rare primary carcinoma that is difficult to diagnose. Multiple tissue blocks are necessary before obtaining all cell types. Special stains for mucin and electron microscopy would be helpful in suspected cases. Hormonal factors might have an impact on the biological behavior of tumors, but further studies are needed to draw conclusions.
[Mh] MeSH terms primary: Breast Neoplasms/diagnosis
Carcinoma, Mucoepidermoid/diagnosis
[Mh] MeSH terms secundary: Adult
Aged
Breast Neoplasms/surgery
Carcinoma, Mucoepidermoid/surgery
Female
Humans
Mastectomy, Modified Radical
Middle Aged
Sentinel Lymph Node Biopsy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009385

  8 / 2417 MEDLINE  
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[PMID]: 29391537
[Au] Autor:Wagner VP; Martins MD; Martins MAT; Almeida LO; Warner KA; Nör JE; Squarize CH; Castilho RM
[Ad] Address:Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109-1078, USA.
[Ti] Title:Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.
[So] Source:Sci Rep;8(1):2065, 2018 Feb 01.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the most common malignancy from the salivary glands. Low survival rates of high-grade Mucoepidermoid Carcinomas (MEC) are particularly associated with the presence of positive lymph nodes, extracapsular lymph node spread, and perineural invasion. Most recently, the presence of cancer stem cells (CSC), and the activation of the NFκB signaling pathway have been suggested as cues for an acquired resistance phenotype. We have previously shown that NFκB signaling is very active in MEC tumors. Herein, we explore the efficacy of NFκB inhibition in combination with class I and II HDAC inhibitor to deplete the population of CSC and to destroy MEC tumor cells. Our finding suggests that disruption of NFκB signaling along with the administration of HDAC inhibitors constitute an effective strategy to manage MEC tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-20345-w

  9 / 2417 MEDLINE  
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[PMID]: 29434341
[Au] Autor:Takamatsu M; Sato Y; Muto M; Nagano H; Ninomiya H; Sakakibara R; Baba S; Sakata S; Takeuchi K; Okumura S; Ishikawa Y
[Ad] Address:Division of Pathology, The Cancer Institute; Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
[Ti] Title:Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas.
[So] Source:Mod Pathol;, 2018 Feb 12.
[Is] ISSN:1530-0285
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hyalinizing clear cell carcinoma of the bronchial glands is a very rare tumor. Since only five reports describing six tumors have been published to date, only a little is known about specific histologic findings and clinical features. Because of its rarity, hyalinizing clear cell carcinoma has not been described in the latest WHO classification of pulmonary tumors yet. Here we present three cases of bronchial hyalinizing clear cell carcinomas, confirmed by both fluorescence in situ hybridization (FISH) and RT-PCR, focusing on histologic and immunohistochemical characteristics in a comparison with three cases of salivary gland origin. In addition, we compared immunohistochemical features with bronchial mucoepidermoid carcinoma, a lesion that needs to be taken into account in differential diagnosis of hyalinizing clear cell carcinoma. All our bronchial hyalinizing clear cell carcinoma cases were surgically resected. Histologically, tumor cells showed clear to eosinophilic cytoplasm with hyalinizing stroma in various proportions, resembling those of salivary gland origin. Immunohistochemically, tumor cells were positive for CK7, CK5/6, p40, p63, and ATF1, while they were negative for TTF1, Napsin A, HMB45, and SOX10. The CK5/6 staining pattern varied in mucoepidermoid carcinomas, while that of hyalinizing clear cell carcinoma was uniformly positive. FISH revealed EWSR1-ATF1 fusion, and RT-PCR with sequencing confirmed specificity of the chimeric gene for hyalinizing clear cell carcinoma. Clinically, bronchial hyalinizing clear cell carcinoma was characterized by occurrence in the fourth to sixth decades, no link with smoking history, and a predilection for the right lung, in line with previous reports. In summary, our study confirmed that the bronchial hyalinizing clear cell carcinoma is a histologically and genetically identical tumor to that of salivary gland origin, and that gene rearrangement analysis can play a critical role in distinction from mucoepidermoid carcinoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1038/s41379-018-0025-7

  10 / 2417 MEDLINE  
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[PMID]: 29338644
[Au] Autor:Kalhor N; Moran CA
[Ad] Address:a Department of Pathology , The University of Texas, M D Anderson Cancer Center , Houston , TX , USA.
[Ti] Title:Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
[So] Source:Expert Rev Respir Med;12(3):249-255, 2018 Mar.
[Is] ISSN:1747-6356
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Primary mucoepidermoid carcinomas (MEC) of the lung are rare and represent a diagnostic challenge. MEC in the lung is under the umbrella of primary salivary gland type tumors of the lung. Areas covered: In general, salivary gland type tumors are represented by malignant neoplasms that may range from low to intermediate to high-grade type of malignancy sharing similar histopathological features as those in salivary glands. The focus in this review will be on one tumor in particular - mucoepidermoid carcinoma. Clinical, radiological, histopathological, and molecular diagnostic features will be highlighted in order to provide an insight on this unusual tumor in the lung. In addition, the treatment of these tumors will be discussed. Expert commentary: It is important to stress that in the majority of cases, the proper use of histopathological assessment is the most important step in arriving at an accurate diagnosis. It is also important to recognized that there are other unusual primary tumoral conditions of the lung, which may pose a significant challenge in the differential diagnosis. The importance of proper recognition of mucoepidermoid carcinoma and its grading will be highlighted in order to assess clinical outcome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.1080/17476348.2018.1428563


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