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[PMID]: 29500752
[Au] Autor:Fancelli M; Borges M; Laumann RA; Pickett JA; Birkett MA; Blassioli-Moraes MC
[Ad] Address:Embrapa Cassava and Fruits, PO Box 007, Cruz das Almas, 44380-000, Brazil. marilene.fancelli@embrapa.br.
[Ti] Title:Attractiveness of Host Plant Volatile Extracts to the Asian Citrus Psyllid, Diaphorina citri, is Reduced by Terpenoids from the Non-Host Cashew.
[So] Source:J Chem Ecol;, 2018 Mar 02.
[Is] ISSN:1573-1561
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Diaphorina citri is a vector of the bacterial causative agent of Huanglongbing (HLB = Citrus greening), a severe disease affecting citrus crops. As there is no known control for HLB, manipulating insect behaviour through deployment of semiochemicals offers a promising opportunity for protecting citrus crops. The behavioural responses of D. citri to plant volatiles, and the identity of these plant volatiles were investigated. Volatiles were collected from host plants Murraya paniculata, Citrus sinensis, C. reshni, C. limettioides, Poncirus trifoliata, and from non-host plants Psidium guajava, Mangifera indica, Anacardium occidentale. In behavioural assays, female D. citri spent more time in the arms containing volatiles from either M. paniculata or C. sinensis compared to the control arms. When D. citri was exposed to volatiles collected from A. occidentale, they preferred the control arm. Volatiles emitted from the other studied plants did not influence the foraging behaviour of D. citri. Chemical analyses of volatile extracts from C. sinensis, M. paniculata, and A. occidentale revealed the presence of the terpenoids (E)-4,8-dimethylnona-1,3,7-triene (DMNT) and (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene (TMTT) in higher amounts in A. occidentale. In further behavioural bioassays, female D. citri spent less time in arms containing a synthetic blend of DMNT and TMTT compared to the control arms. Female D. citri also spent less time in arms containing the synthetic blend in combination with volatile extracts from either M. paniculata or C. sinensis compared to the control arms. Results suggest that higher release of the two terpenoids by A. occidentale make this species unattractive to D. citri, and that the terpenoids could be used in reducing colonisation of citrus plants and therefore HLB infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1007/s10886-018-0937-1

  2 / 336 MEDLINE  
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[PMID]: 29497736
[Au] Autor:Nalli Y; Khajuria V; Gupta S; Arora P; Riyaz-Ul-Hassan S; Ahmed Z; Ali A
[Ad] Address:Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India. asifali@iiim.ac.in asifchem73@gmail.com and Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K
[Ti] Title:Correction: Four new carbazole alkaloids from Murraya koenigii that display anti-inflammatory and anti-microbial activities.
[So] Source:Org Biomol Chem;, 2018 Mar 02.
[Is] ISSN:1477-0539
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Correction for 'Four new carbazole alkaloids from Murraya koenigii that display anti-inflammatory and anti-microbial activities' by Yedukondalu Nalli et al., Org. Biomol. Chem., 2016, 14, 3322-3332.
[Pt] Publication type:PUBLISHED ERRATUM
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1039/c8ob90030b

  3 / 336 MEDLINE  
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[PMID]: 29385309
[Au] Autor:Yan R; Shen J; Liu X; Zou Y; Xu X
[Ad] Address:School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
[Ti] Title:Preparative isolation and purification of hainanmurpanin, meranzin, and phebalosin from leaves of Murraya exotica L. using supercritical fluid extraction combined with consecutive high-speed countercurrent chromatography.
[So] Source:J Sep Sci;, 2018 Jan 31.
[Is] ISSN:1615-9314
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The objective of this study was to develop a consecutive preparation method for the isolation and purification of hainanmurpanin, meranzin, and phebalosin from leaves of Murraya exotica L. The process involved supercritical fluid extraction with CO , solvent extraction, and two-step high-speed countercurrent chromatography. Pressure, temperature, and the volume of entrainer were optimized as 27 MPa, 52°C, and 60 mL by response surface methodology in supercritical fluid extraction with CO , and the yield of the crude extracts was 7.91 g from 100 g of leaves. Subsequently, 80% methanol/water was used to extract and condense the three compounds from the crude extracts, and 4.23 g of methanol/water extracts was obtained. Then, a two-step high-speed countercurrent chromatography procedure was developed for the isolation of the three target compounds from methanol/water extracts, including conventional high-speed countercurrent chromatography for further enrichment and consecutive high-speed countercurrent chromatography for purification. The yield of concentrates from high-speed countercurrent chromatography was 2.50 g from 4.23 g of methanol/water extracts. Finally, the consecutive high-speed countercurrent chromatography produced 103.2 mg of hainanmurpanin, 244.7 mg of meranzin, and 255.4 mg of phebalosin with purities up to 97.66, 99.36, and 98.64%, respectively, from 900 mg of high-speed countercurrent chromatography concentrates in one run of three consecutive sample loadings without exchanging a solvent system.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1002/jssc.201701423

  4 / 336 MEDLINE  
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[PMID]: 29175114
[Au] Autor:Samanta SK; Kandimalla R; Gogoi B; Dutta KN; Choudhury P; Deb PK; Devi R; Pal BC; Talukdar NC
[Ad] Address:Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India. Electronic address: suman_samanta699@yahoo.co.in.
[Ti] Title:Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine.
[So] Source:Pharmacol Res;129:227-236, 2018 Mar.
[Is] ISSN:1096-1186
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileishmanial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scientific evidence derived not only from in vitro cellular experiments but also from in vivo studies in various cancer models is accumulating for the pronounced anticancer effects of mahanine. The primary objective of this review is to summarize research data on cytotoxic chemical constituents present in different parts of Murraya koenigii and the anticancer activity of mahanine along with the recent understanding on the mechanism of its action in diverse cancer models. The information on its bioavailability and the toxicity generated from the recent studies have also been incorporated in the review.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Data-Review

  5 / 336 MEDLINE  
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[PMID]: 28930531
[Au] Autor:Balakrishnan R; Elangovan N; Mohankumar T; Nataraj J; Manivasagam T; Justin Thenmozhi A; Essa MM; Akbar M; Abdul Sattar Khan M
[Ad] Address:Department of Biotechnology, School of Biosciences, Periyar University, Periyar Palkalai nagar, Salem-636011, Tamilnadu, India.
[Ti] Title:Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis.
[So] Source:Front Biosci (Schol Ed);10:248-261, 2018 01 01.
[Is] ISSN:1945-0524
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The present study was carried out to investigate the neuroprotective effects of isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model. SH-SY5Y human neuroblastoma cells were divided into four experimental groups (control, rotenone (100 nM), ILF (10 microM) + rotenone (100 nanoM), ILF 10 microM alone treated) based on 3-(4, 5-dimethyl 2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results of the present study showed that the ILF treatment significantly alleviated rotenone-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in SH-SY5Y cells. Moreover, ILF attenuated rotenone induced toxicity by down-regulating  Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3 beta expression by ILF, clearly confirmed its protective effects. Taken together, our results suggested that ILF attenuated rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3 beta signaling pathways. However further pre-clinical studies are warranted in rodents to use ILF as a promising therapeutic agent for PD in future.
[Mh] MeSH terms primary: Mitochondria/drug effects
Neuroprotective Agents/pharmacology
Oxidative Stress/drug effects
Rotenone/pharmacology
Sesquiterpenes/pharmacology
[Mh] MeSH terms secundary: Antioxidants/metabolism
Apoptosis/drug effects
Cell Line, Tumor
Cell Survival/drug effects
Drug Interactions
Glycogen Synthase Kinase 3/metabolism
Humans
Lipid Peroxidation/drug effects
Neuroblastoma
Phosphatidylinositol 3-Kinases/metabolism
Proto-Oncogene Proteins c-akt/metabolism
Reactive Oxygen Species/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Neuroprotective Agents); 0 (Reactive Oxygen Species); 0 (Sesquiterpenes); 0 (isolongifolenone); 03L9OT429T (Rotenone); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.26 (Glycogen Synthase Kinase 3)
[Em] Entry month:1712
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[Js] Journal subset:IM
[Da] Date of entry for processing:170921
[St] Status:MEDLINE

  6 / 336 MEDLINE  
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[PMID]: 29367741
[Au] Autor:Meng L; Wang Y; Wei WH; Zhang H
[Ad] Address:Key Laboratory of Horticultural Plant Biology (MOE), State Key Laboratory of Agricultural Microbiology, Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
[Ti] Title:Population genetic structure of Diaphorina citri Kuwayama (Hemiptera: Liviidae): host-driven genetic differentiation in China.
[So] Source:Sci Rep;8(1):1473, 2018 Jan 24.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The Asian citrus psyllid Diaphorina citri Kuwayama is a major pest in citrus production, transmitting Candidatus Liberibacter asiaticus. It has spread widely across eastern and southern China. Unfortunately, little is known about the genetic diversity and population structure of D. citri, making pest control difficult. In this study, nine specifically developed SSR markers and three known mitochondrial DNA were used for population genetics study of D. citri using 225 samples collected from all 7 distribution regions in China. Based on the SSR data, D. citri was found highly diverse with a mean observed heterozygosity of 0.50, and three subgroups were structured by host plant: (i) Shatangju, NF mandarin and Ponkan; (ii) Murraya paniculata and Lemon; (iii) Citrus unshiu, Bingtangcheng, Summer orange and Navel. No significant genetic differences were found with mtDNA data. We suggested the host-associated divergence is likely to have occurred very recently. A unimodal distribution of paired differences, the negative and significant Tajima's D and Fu's F parameters among mtDNA suggested a recent demographic expansion. The extensive citrus cultivation and increased suitable living habitat was recommended as a key for this expansion event.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-19533-5

  7 / 336 MEDLINE  
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[PMID]: 29303577
[Au] Autor:Liu BY; Zhang C; Zeng KW; Li J; Guo XY; Zhao MB; Tu PF; Jiang Y
[Ad] Address:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191, People's Republic of China.
[Ti] Title:Anti-Inflammatory Prenylated Phenylpropenols and Coumarin Derivatives from Murraya exotica.
[So] Source:J Nat Prod;, 2018 Jan 05.
[Is] ISSN:1520-6025
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Three new prenylated phenylpropenols, exotiacetals A-C (1-3), 10 new coumarin derivatives, exotimarins A-I (4-13), and 35 known analogues (14-48) were isolated from the roots of Murraya exotica. The absolute configurations of the new compounds were assigned via comparison of their specific rotations, single-crystal X-ray diffraction data, Mosher's method, the ECD exciton coupling method, comparison of experimental and calculated ECD data, and the ECD data of the in situ formed transition metal complexes. Compounds 1-3, which possess an unprecedented hexahydro-1H-isochromen-1-ol system, are presumably biosynthesized from two prenylated p-coumaryl alcohol moieties via Diels-Alder [4+2] cycloaddition and cyclic hemiacetal formation reactions. Compounds 1, 28, 33, and 35 demonstrated inhibition against LPS-induced NO production in BV-2 microglial cells with IC values of 8.6 ± 0.3, 11.8 ± 0.9, 15.5 ± 0.9, and 16.9 ± 1.0 µM, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:Publisher
[do] DOI:10.1021/acs.jnatprod.7b00518

  8 / 336 MEDLINE  
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[PMID]: 29207888
[Au] Autor:Tiwari BK; Abidi AB; Rizvi SI; Pandey KB
[Ad] Address:a Department of Biochemistry and Biochemical Engineering , Sam Higginbottom Institute of Agriculture, Technology and Sciences (SHIATS) , Allahabad , India.
[Ti] Title:Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats.
[So] Source:Arch Physiol Biochem;:1-6, 2017 Dec 06.
[Is] ISSN:1744-4160
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain tissues of alloxan-induced diabetic rats in vivo. Enhanced lipid peroxidation, protein oxidation and reduced antioxidative defence systems were measured in brain tissues of diabetic rats. Supplementation of CLE, once in a day for 35 days significantly (p < .05) protected the peroxidation of lipid, oxidation of protein and ameliorated the antioxidant defence in brain tissue of diabetic rats. It was observed that the insulin-like effect of CLE was dose dependent; higher effect at higher doses. The results of the study suggest that supplementation CLE may provide an overall homeostasis and significant neuro-protection through rescuing brain cells from oxidative abuse and accelerating brain antioxidative defence during advanced stage of hyperglycaemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171206
[Lr] Last revision date:171206
[St] Status:Publisher
[do] DOI:10.1080/13813455.2017.1411369

  9 / 336 MEDLINE  
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[PMID]: 29090551
[Au] Autor:Chen YM; Cao NK; Tu PF; Jiang Y
[Ad] Address:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
[Ti] Title:[Chemical constituents from Murraya euchrestifolia].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(10):1916-1921, 2017 May.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:The open silica gel, ODS, and Sephadex LH-20 column chromatography, along with the semi-preparative HPLC was used to isolate and purify the chemical constituents from Murraya euchrestifolia. The structures of the isolates were elucidated by their physiochemical properties, NMR, and MS spectroscopic data, as well as comparison with literature data. Eighteen compounds were isolated from the CH2Cl2 fraction of the 95% aqueous EtOH extract of M. euchrestifolia, and their structures were identified as sakuranetin (1), eriodictyol-7,4'-dimethyl ether (2), isosakuranetin (3), 5-hydroxy-7,4'-dimethoxyflavanone (4), eriodictyol-7-methyl ether (5), lichexanthon (6), 5,6,7-trimethoxycoumarin (7), 5-hydroxy-6,8-dimethoxycoumarin (8), 8-hydroxy-6-methoxy-3-n-pentylisocoumarin (9), ethyl caffeate (10), 4-hydroxy-3,5- dimethoxycinnamic acid ethyl ester (11), methyl 3-(5'-hydroxyprenyl)-coumarate (12), (E)-coniferol (13), ß-hydroxypropiovanillone (14), 3-hydroxy-7,8-didehydro-ß-ionone (15), 3ß-hydroxy-5α, 6α-epoxy-7-megastigmen-9-one (16), grasshopper ketone (17), and 4-hydroxy-3,5-dimethoxybenzaldehyde (18). Compounds 1-15 and 18 were first obtained from the plants of Murraya genus, and compounds 16 and 17 were isolated from M. euchrestifolia for the first time.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:In-Data-Review
[do] DOI:10.19540/j.cnki.cjcmm.20170228.002

  10 / 336 MEDLINE  
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[PMID]: 29050941
[Au] Autor:Nooron N; Athipornchai A; Suksamrarn A; Chiabchalard A
[Ad] Address:Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
[Ti] Title:Mahanine enhances the glucose-lowering mechanisms in skeletal muscle and adipocyte cells.
[So] Source:Biochem Biophys Res Commun;494(1-2):101-106, 2017 Dec 09.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Insulin resistance is a major defect underlying type 2 diabetes development. Skeletal muscle tissue and adipocyte tissue are the major sites of postprandial glucose disposal, and enhancing glucose uptake into this tissue may decrease insulin resistance in type 2 diabetes patients. Mahanine (3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-pentenyl)pyrano[3,2-a]carbazol-9-ol) has been reported to be a major bioactive carbazole alkaloid that has many biological activities including antitumor, anti-inflammatory, antioxidant and anti-diabetic activities. However, the molecular mechanism and signaling pathways mediating the anti-diabetic effects of mahanine require further investigation. Therefore, the aim of this study was to investigate the effects of mahanine, a carbazole alkaloid from Murraya koenigii, on glucose uptake and glucose transporter 4 (GLUT4) translocation in skeletal muscle and adipocyte cells. Mahanine treatment promoted a dose dependent increased in glucose uptake in L6 myotubes and adipocyte cells via activation of the Akt signaling pathway. Mahanine induced Akt-activation was reversed by co-treatment with wortmannin, an Akt inhibitor. Moreover, it was found that mahanine significantly enhanced GLUT4 translocation to the plasma membrane in L6 myotubes. These results suggest that increased activation of the Akt signaling pathway lead to increased plasma membrane GLUT4 content and increased glucose uptake. These data strongly suggest that mahanine has anti-diabetic potential for treating diabetes.
[Mh] MeSH terms primary: Adipocytes/drug effects
Adipocytes/metabolism
Carbazoles/pharmacology
Glucose/metabolism
Hypoglycemic Agents/pharmacology
Muscle, Skeletal/drug effects
Muscle, Skeletal/metabolism
[Mh] MeSH terms secundary: 3T3-L1 Cells
AMP-Activated Protein Kinases/metabolism
Animals
Biological Transport, Active/drug effects
Carbazoles/administration & dosage
Cell Line
Cell Membrane/drug effects
Cell Membrane/metabolism
Cell Survival/drug effects
Dose-Response Relationship, Drug
Glucose Transporter Type 4/metabolism
Hypoglycemic Agents/administration & dosage
Insulin Resistance
Mice
Muscle Fibers, Skeletal/drug effects
Muscle Fibers, Skeletal/metabolism
Proto-Oncogene Proteins c-akt/metabolism
Signal Transduction/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Carbazoles); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Slc2a4 protein, mouse); 0 (mahanine); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.31 (AMP-Activated Protein Kinases); IY9XDZ35W2 (Glucose)
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:171021
[St] Status:MEDLINE


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