Database : MEDLINE
Search on : Muscle and Cramp [Words]
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[PMID]: 28448298
[Au] Autor:Katz JA; Murphy GS
[Ad] Address:Northshore University Health System, University of Chicago, Pritzker School of Medicine, Illinois, USA.
[Ti] Title:Anesthetic consideration for neuromuscular diseases.
[So] Source:Curr Opin Anaesthesiol;30(3):435-440, 2017 Jun.
[Is] ISSN:1473-6500
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE OF REVIEW: The aim of this review is to examine data relating to perioperative management of the patient with neuromuscular disorders RECENT FINDINGS: Patients with pre-existing neuromuscular disorders are at risk for a number of postoperative complications that are related to anesthetic drugs that are administered intraoperatively. Careful preoperative assessment is necessary to reduce morbidity and mortality. In particular, the risk of postoperative respiratory failure and need for long-term ventilation should be reviewed with patients. The use of succinylcholine should be avoided in muscular dystrophies, motor neuron diseases, and intrinsic muscle disease due to a risk of malignant hyperthermia, hyperkalemia, rhabdomyolysis, and cardiac arrest. The use of quantitative neuromuscular monitoring should be strongly considered whenever nondepolarizing neuromuscular blocking agents are administered. A number of case series and reports have been recently published demonstrating that sugammadex can be safely used in patients with neuromuscular disease; the risk of residual neuromuscular is nearly eliminated when this agent is administered intraoperatively. SUMMARY: Careful assessment and management of patients with underlying neuromuscular diseases is required to reduce postoperative complications. This article reviews the anesthetic implications of patients undergoing surgery with neuromuscular disorder.
[Mh] MeSH terms primary: Anesthesia/adverse effects
Anesthetics/adverse effects
Neuromuscular Blocking Agents/adverse effects
Neuromuscular Diseases/complications
Perioperative Care/methods
Postoperative Complications/etiology
Surgical Procedures, Operative/adverse effects
[Mh] MeSH terms secundary: Anesthesia/methods
Anesthetics/administration & dosage
Heart Arrest/chemically induced
Heart Arrest/prevention & control
Humans
Hyperkalemia/chemically induced
Intraoperative Complications/chemically induced
Intraoperative Complications/prevention & control
Malignant Hyperthermia/etiology
Neuromuscular Blocking Agents/administration & dosage
Neuromuscular Diseases/epidemiology
Neuromuscular Monitoring
Postoperative Complications/prevention & control
Prevalence
Respiratory Insufficiency/prevention & control
Rhabdomyolysis/chemically induced
Rhabdomyolysis/prevention & control
Risk Assessment
Succinylcholine/administration & dosage
Succinylcholine/adverse effects
gamma-Cyclodextrins/administration & dosage
gamma-Cyclodextrins/adverse effects
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anesthetics); 0 (Neuromuscular Blocking Agents); 0 (gamma-Cyclodextrins); 361LPM2T56 (Sugammadex); J2R869A8YF (Succinylcholine)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:170428
[St] Status:MEDLINE
[do] DOI:10.1097/ACO.0000000000000466

  2 / 7424 MEDLINE  
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[PMID]: 29510461
[Au] Autor:Oskarsson B; Moore D; Mozaffar T; Ravits J; Wiedau-Pazos M; Parziale N; Joyce NC; Mandeville R; Goyal N; Cudkowicz ME; Weiss M; Miller RG; McDonald CM
[Ad] Address:Departments of Neurology and Pathology, University of California, Davis, Sacramento, California.
[Ti] Title:Mexiletine for Muscle Cramps in ALS: A Randomized Double-Blind Crossover Trial.
[So] Source:Muscle Nerve;, 2018 Mar 06.
[Is] ISSN:1097-4598
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: More than 90% of amyotrophic lateral sclerosis (ALS) patients have muscle cramps, and evidence-based treatments have not been available. METHODS: A multicenter double-blind placebo-controlled crossover trial of mexiletine 150 mg twice daily was conducted of ALS patients requesting treatment of symptomatic muscle cramps. RESULTS: Muscle cramp frequency was reduced in 18 of 20 patients; 13 reductions were attributed to treatment (P<.05). The average reduction was 1.8 cramps per day (a reduction from 5.3 with placebo to 3.5 with mexiletine) based on t tests. The estimated reduction of cramp severity was 15 units on a 100-unit scale (P=.01), from a baseline average of 46. No effect on fasciculations was noted. One patient discontinued the study because of dizziness, and another patient discontinued the study to start open-label mexiletine therapy. No serious adverse event occurred. DISCUSSION: Mexiletine is well-tolerated and effective medication for controlling the symptom of muscle cramps in ALS. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/mus.26117

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[PMID]: 29515058
[Au] Autor:Imbe A; Tanimoto K; Inaba Y; Sakai S; Shishikura K; Imbe H; Tanimoto Y; Terasaki J; Imagawa A; Hanafusa T
[Ad] Address:Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Osaka 569-8686, Japan.
[Ti] Title:Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps.
[So] Source:Endocr J;, 2018 Mar 06.
[Is] ISSN:1348-4540
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Diabetic patients often suffer from muscle cramps. This study aimed to compare the quality of life (QOL) of diabetic patients with and without muscle cramps and to investigate the effect of L-carnitine supplementation in diabetic patients with muscle cramps. A total of 91 patients with diabetes were enrolled in this study: 69 patients with muscle cramps and 22 patients without muscle cramps. Muscle cramps and QOL were evaluated using the muscle cramp questionnaire and the Short Form 36 health survey version 2 (SF-36), respectively. Clinical characteristics were compared between diabetic patients with and without muscle cramps. In the prospective portion of the study, 25 diabetic patients with muscle cramps received L-carnitine supplementation (600 mg/day orally) for 4 months. The questionnaires were administered before and after supplementation. The SF-36 scores in diabetic patients with muscle cramps were lower than those in patients without muscle cramps on the subscales of physical function, role physical, bodily pain, vitality, general health, and social function. In the 25 patients with muscle cramps who received L-carnitine supplementation, the monthly frequency of muscle cramps and Wong-Baker FACES Pain Rating Scale scores were significantly decreased. Scores on the following SF-36 subscales improved after L-carnitine supplementation: body pain, vitality, social function, and role emotional. This study demonstrated that muscle cramps decrease the QOL in patients with diabetes, and L-carnitine supplementation may improve the QOL by reducing the frequency and severity of muscle cramps in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1507/endocrj.EJ17-0431

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[PMID]: 28452906
[Au] Autor:Hsu CW; Lee Y; Lee CY; Lin PY
[Ad] Address:Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
[Ti] Title:Reversible Pisa Syndrome Induced by Rivastigmine in a Patient With Early-Onset Alzheimer Disease.
[So] Source:Clin Neuropharmacol;40(3):147-148, 2017 May/Jun.
[Is] ISSN:1537-162X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pisa syndrome (PS) is a state of dystonic muscle contraction with a marked truncal deviation to one side. It is an uncommon adverse effect of antipsychotic drugs, but is rarely reported in patients receiving acetylcholinesterase inhibitors, especially rivastigmine. We present a 57-year-old female patient with Alzheimer disease who began to develop symptoms of dementia at the age of 51 years. She was observed to have symptoms of PS after continuous use of rivastigmine (9 mg/d) for nearly 2 years. The PS symptoms improved after the dose of rivastigmine was reduced but recurred when the dose was added back to 9 mg/d. Finally, after we decreased the dose to 4.5 mg/d, her PS symptoms were remitted. This report reminds us that clinicians need to be cautious about the risk of PS when prescribing rivastigmine in a patient with early-onset Alzheimer disease.
[Mh] MeSH terms primary: Alzheimer Disease/drug therapy
Cholinesterase Inhibitors/adverse effects
Neuroprotective Agents/adverse effects
Neurotoxicity Syndromes/therapy
Rivastigmine/adverse effects
[Mh] MeSH terms secundary: Cholinesterase Inhibitors/administration & dosage
Cholinesterase Inhibitors/therapeutic use
Dose-Response Relationship, Drug
Drug Monitoring
Dystonic Disorders/etiology
Dystonic Disorders/prevention & control
Female
Humans
Middle Aged
Neuroimaging
Neuroprotective Agents/administration & dosage
Neuroprotective Agents/therapeutic use
Neurotoxicity Syndromes/diagnostic imaging
Neurotoxicity Syndromes/physiopathology
Rivastigmine/administration & dosage
Rivastigmine/therapeutic use
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Cholinesterase Inhibitors); 0 (Neuroprotective Agents); PKI06M3IW0 (Rivastigmine)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1097/WNF.0000000000000215

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[PMID]: 29475990
[Au] Autor:Cohen DL; Townsend RR
[Ad] Address:Renal, Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania debbie.cohen@uphs.upenn.edu.
[Ti] Title:Approach to the Young Patient with New-Onset Hypertension.
[So] Source:Clin J Am Soc Nephrol;, 2018 Feb 23.
[Is] ISSN:1555-905X
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180224
[Lr] Last revision date:180224
[St] Status:Publisher

  6 / 7424 MEDLINE  
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[PMID]: 28455453
[Au] Autor:Volodina O; Ganesan S; Pearce SC; Gabler NK; Baumgard LH; Rhoads RP; Selsby JT
[Ad] Address:Department of Animal Science, Iowa State University, Ames, Iowa.
[Ti] Title:Short-term heat stress alters redox balance in porcine skeletal muscle.
[So] Source:Physiol Rep;5(8), 2017 Apr.
[Is] ISSN:2051-817X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Heat stress contributes to higher morbidity and mortality in humans and animals and is an agricultural economic challenge because it reduces livestock productivity. Redox balance and associated mitochondrial responses appear to play a central role in heat stress-induced skeletal muscle pathology. We have previously reported increased oxidative stress and mitochondrial content in oxidative muscle following 12 h of heat stress. The purposes of this investigation were to characterize heat stress-induced oxidative stress and changes in mitochondrial content and biogenic signaling in oxidative skeletal muscle. Crossbred gilts were randomly assigned to either thermal neutral (21°C;  = 8, control group) or heat stress (37°C) conditions for 2 h ( = 8), 4 h ( = 8), or 6 h ( = 8). At the end, their respective environmental exposure, the red portion of the semitendinosus muscle (STR) was harvested. Heat stress increased concentration of malondialdehyde (MDA) following 2 and 4 h compared to thermal neutral and 6 h, which was similar to thermal neutral, and decreased linearly with time. Protein carbonyl content was not influenced by environment. Catalase activity was increased following 4 h of heat stress and superoxide dismutase activity was decreased following 6 h of heat stress compared to thermal neutral conditions. Heat stress-mediated changes in antioxidant activity were independent of altered protein abundance or transcript expression. Mitochondrial content and mitochondrial biogenic signaling were similar between groups. These data demonstrate that heat stress caused a transient increase in oxidative stress that was countered by a compensatory change in catalase activity. These findings contribute to our growing understanding of the chronology of heat stress-induced intracellular dysfunctions in skeletal muscle.
[Mh] MeSH terms primary: Heat Stress Disorders/metabolism
Muscle, Skeletal/metabolism
Swine Diseases/metabolism
[Mh] MeSH terms secundary: Animals
Endoplasmic Reticulum/physiology
Heat Stress Disorders/physiopathology
Hot Temperature/adverse effects
Male
Mitochondria, Muscle/metabolism
Muscle, Skeletal/physiopathology
Organelle Biogenesis
Oxidation-Reduction
Oxidative Stress/physiology
Phenotype
Sus scrofa
Swine
Swine Diseases/physiopathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[Js] Journal subset:IM
[Da] Date of entry for processing:170430
[St] Status:MEDLINE

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[PMID]: 29357208
[Au] Autor:Weiker MK; Nielsen B; Waclawik AJ; Staples AC; Hansen KE
[Ad] Address:Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
[Ti] Title:Muscle Cramps Do Not Improve With Correction of Vitamin D Insufficiency.
[So] Source:WMJ;116(5):200-204, 2017 Dec.
[Is] ISSN:1098-1861
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Minimal treatment options exist for idiopathic muscle cramps. OBJECTIVE: We evaluated whether correction of vitamin D insufficiency relieved muscle cramps in postmenopausal women. METHODS: We conducted a post hoc analysis of a randomized, double-blind, placebo-controlled trial at a single academic medical center in the Midwest to evaluate the benefits of treating vitamin D insufficiency. Two hundred thirty postmenopausal women participated. Eligible women were ≤75 years old, 5 years past menopause or oophorectomy, or ≥60 years if they had previously undergone hysterectomy without oophorectomy. Women had vitamin D insufficiency at baseline (25-hydroxyvitamin D 14-27 ng/mL). We excluded subjects with a glomerular filtration rate <45 mL/minute. INTERVENTIONS FOR CLINICAL TRIALS: Participants completed food diaries, laboratory studies, and functional tests including the Timed Up and Go test, Physical Activity Scale for the Elderly, Health Assessment Questionnaire (a measure of disability), and pain scores. Subjects recorded muscle cramp frequency and severity using a standardized form at 6 visits over 1 year. RESULTS: During the trial, over half of participants (n=121, 53%) reported muscle cramps. Despite unequivocal vitamin D repletion, vitamin D had no effect on muscle cramps. Pain levels, disability, and dietary potassium predicted presence of cramps. Serum albumin and physical activity were inversely associated with, and disability was positively associated with, severity of muscle cramps. CONCLUSIONS: Further studies are needed to evaluate the link between pain, disability, dietary potassium intake, and muscle cramps.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process

  8 / 7424 MEDLINE  
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[PMID]: 29286305
[Au] Autor:Karp BI; Alter K
[Ad] Address:Combined NeuroScience IRB, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. karpb@ninds.nih.gov.
[Ti] Title:Muscle Selection for Focal Limb Dystonia.
[So] Source:Toxins (Basel);10(1), 2017 Dec 29.
[Is] ISSN:2072-6651
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Selection of muscles for botulinum toxin injection for limb dystonia is particularly challenging. Limb dystonias vary more widely in the pattern of dystonic movement and involved muscles than cervical dystonia or blepharospasm. The large variation in how healthy individuals perform skilled hand movements, the large number of muscles in the hand and forearm, and the presence of compensatory actions in patients with dystonia add to the complexity of choosing muscles for injection. In this article, we discuss approaches to selecting upper and lower extremity muscles for chemodenervation treatment of limb dystonia.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Data-Review

  9 / 7424 MEDLINE  
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SciELO Brazil full text

[PMID]: 29236822
[Au] Autor:Cotta A; Paim JF; Carvalho E; da-Cunha-Júnior AL; Navarro MM; Valicek J; Menezes MM; Nunes SV; Xavier-Neto R; Baptista S; Lima LR; Takata RI; Vargas AP
[Ad] Address:Rede SARAH de Hospitais de Reabilitação, Departamento de Patologia, Belo Horizonte MG, Brasil.
[Ti] Title:The relative frequency of common neuromuscular diagnoses in a reference center.
[So] Source:Arq Neuropsiquiatr;75(11):789-795, 2017 Nov.
[Is] ISSN:1678-4227
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The diagnostic procedure in neuromuscular patients is complex. Knowledge of the relative frequency of neuromuscular diseases within the investigated population is important to allow the neurologist to perform the most appropriate diagnostic tests. OBJECTIVE: To report the relative frequency of common neuromuscular diagnoses in a reference center. METHODS: A 17-year chart review of patients with suspicion of myopathy. RESULTS: Among 3,412 examinations, 1,603 (46.98%) yielded confirmatory results: 782 (48.78%) underwent molecular studies, and 821 (51.21%) had muscle biopsies. The most frequent diagnoses were: dystrophinopathy 460 (28.70%), mitochondriopathy 330 (20.59%), spinal muscular atrophy 158 (9.86%), limb girdle muscular dystrophy 157 (9.79%), Steinert myotonic dystrophy 138 (8.61%), facioscapulohumeral muscular dystrophy 99 (6.17%), and other diagnoses 261 (16.28%). CONCLUSION: Using the presently-available diagnostic techniques in this service, a specific limb girdle muscular dystrophy subtype diagnosis was reached in 61% of the patients. A neuromuscular-appropriate diagnosis is important for genetic counseling, rehabilitation orientation, and early treatment of respiratory and cardiac complications.
[Mh] MeSH terms primary: Neuromuscular Diseases/diagnosis
[Mh] MeSH terms secundary: Biopsy
Female
Humans
Male
Neuromuscular Diseases/genetics
Neuromuscular Diseases/pathology
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Js] Journal subset:IM
[Da] Date of entry for processing:171214
[St] Status:MEDLINE

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Clinical Trials Registry
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[PMID]: 28747452
[Au] Autor:Fasano A; Llinas M; Munhoz RP; Hlasny E; Kucharczyk W; Lozano AM
[Ad] Address:From the Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease (A.F., R.P.M.), Toronto Western Hospital-UHN, Division of Neurology, University of Toronto; Krembil Research Institute (A.F.); Division of Neurosurgery (M.L., A.M.L.), Department of Surger
[Ti] Title:MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes.
[So] Source:Neurology;89(8):771-775, 2017 Aug 22.
[Is] ISSN:1526-632X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To report the 6-month single-blinded results of unilateral thalamotomy with MRI-guided focused ultrasound (MRgFUS) in patients with tremors other than essential tremor. METHODS: Three patients with tremor due to Parkinson disease, 2 with dystonic tremor in the context of cervicobrachial dystonia and writer's cramp, and 1 with dystonia gene-associated tremor underwent MRgFUS targeting the ventro-intermedius nucleus (Vim) of the dominant hemisphere. The primary endpoint was the reduction of lateralized items of the Tremor Rating Scale of contralateral hemibody assessed by a blinded rater. RESULTS: All patients achieved a statistically significant, immediate, and sustained improvement of the contralateral tremor score by 42.2%, 52.0%, 55.9%, and 52.9% at 1 week and 1, 3, and 6 months after the procedure, respectively. All patients experienced transient side effects and 2 patients experienced persistent side effects at the time of last evaluation: hemitongue numbness and hemiparesis with hemihypoesthesia. CONCLUSIONS: Vim MRgFUS is a promising, incision-free, but nevertheless invasive technique to effectively treat tremors other than essential tremor. Future studies on larger samples and longer follow-up will further define its effectiveness and safety. CLINICALTRIALSGOV IDENTIFIER: NCT02252380. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that for patients with tremor not caused by essential tremor, MRgFUS of the Vim improves the tremor of the contralateral hemibody at 6 months.
[Mh] MeSH terms primary: High-Intensity Focused Ultrasound Ablation
Magnetic Resonance Imaging, Interventional
Thalamus/diagnostic imaging
Thalamus/surgery
Tremor/diagnostic imaging
Tremor/surgery
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Female
Functional Laterality
High-Intensity Focused Ultrasound Ablation/adverse effects
Humans
Male
Middle Aged
Severity of Illness Index
Single-Blind Method
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 180124
[Lr] Last revision date:180124
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170728
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004268


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