Database : MEDLINE
Search on : Myxoma [Words]
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[PMID]: 29504977
[Au] Autor:Li Y; Li X; Wang X; Chen L
[Ad] Address:Department of Echocardiography, Center of Cardiovascular diseases, The First Hospital of Jilin University, Changchun, China.
[Ti] Title:Biatrial myxoma floating like a butterfly: A case report and review of the literature.
[So] Source:Medicine (Baltimore);97(3):e9558, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Myxoma is the most common type of primary benign cardiac tumor in adults. The left atrium is the most frequent site of origin followed by the right atrium. Biatrial myxoma is extremely rare. PATIENT CONCERNS: We present a case of a 60-year-old woman with biatrial myxoma, who presented with palpitations for one month. DIAGNOSES: Echocardiography revealed an irregular homogeneous mass in the left atrium and in the right atrium, and were connected via the fossa ovalis suspiciously. Computed tomography angiography revealed a hypo-intense mass in both atria. INTERVENTIONS: The tumors were successfully removed by surgical excision and histological analysis confirmed the diagnosis. OUTCOMES: The patient was discharged one week after surgery, and did not experience recurrence during the two years follow-up period. LESSONS: Biatrial myxoma is rare. Surgical resection is the mainstay of treatment and there is no recurrence reported. The clinical data and the features on echocardiogram of biatrial myxoma are reviewed, providing important clinical information for the pre-operative diagnosis and intraoperative removal of biatrial myxoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1097/MD.0000000000009558

  2 / 8030 MEDLINE  
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[PMID]: 29429162
[Au] Autor:Gong QX; Li H; Zhang ZH; Fan QH
[Ad] Address:Department of Pathology, the First Affiliated Hospital to Nanjing Medical University, Nanjing 210029, China.
[Ti] Title:[Pulmonary microcystic fibromyxoma: report of a case with review of literature].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):110-113, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To study the clinicopathologic features, diagnosis and differential diagnosis of pulmonary microcystic fibromyxoma. In March 2014, at the First Affiliated Hospital to Nanjing Medical University a 58-year-old female patient of pulmonary microcystic fibromyxoma was collected. The clinicopathologic, immunohistochemical and genetic profile of a case of pulmonary microcystic fibromyxoma were studied, and the relevant literature reviewed. The patient was a 58-year-old female who presented with cough and sputum for 1 month. CT scan disclosed a 15 mm nodule in her right middle lobe of lung. The patient underwent a wedge resection with negative margin. Grossly, a well-demarcated peripheral lung nodule was detected, measuring 1.5 cm×1.5 cm×1.0 cm, with myxoid tan-white cut surface containing microcysts. Microscopically, the tumor was composed of bland spindled to stellate-shaped cells widely spaced within prominent fibromyxoid stroma with prominent cystic change. No mitosis or necrosis was present. There were inconspicuous slim curvilinear capillaries and occasional collection of stromal lymphocytes and plasma cells. Immunohistochemically, the tumor cells were positive for vimentin, but negative for CD34, SMA, desmin, S-100 protein, ALK, CKpan, EMA, calretinin and TTF1. Fluorescence in situ hybridization did not show chromosomal translocation involving EWSR1, DDIT3 or FUS genes. The patient was recurrence or metastasis free after follow-up for 38 months. Pulmonary microcystic fibromyxoma is a rare benign lesion that should be differentiated from other lung tumors with myxoid characteristics.
[Mh] MeSH terms primary: Fibroma/chemistry
Fibroma/pathology
Lung Neoplasms/chemistry
Lung Neoplasms/pathology
[Mh] MeSH terms secundary: Calmodulin-Binding Proteins/analysis
Diagnosis, Differential
Female
Humans
In Situ Hybridization, Fluorescence
Middle Aged
RNA-Binding Protein EWS/analysis
S100 Proteins/analysis
Tomography, X-Ray Computed
Vimentin/analysis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Calmodulin-Binding Proteins); 0 (EWSR1 protein, human); 0 (RNA-Binding Protein EWS); 0 (S100 Proteins); 0 (Vimentin)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.006

  3 / 8030 MEDLINE  
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[PMID]: 29506452
[Au] Autor:Azad S; Dutta N; Roy Chowdhuri K; Ramman TR; Chandra N; Radhakrishnan S; Iyer KS
[Ad] Address:1 Department of Pediatric and Congenital Heart Sciences, Fortis Escorts Heart Institute, New Delhi, India.
[Ti] Title:Atypical Left Ventricular Myxoma: Unusual Echocardiographic and Histopathological Features.
[So] Source:World J Pediatr Congenit Heart Surg;:2150135117742626, 2018 Jan 01.
[Is] ISSN:2150-136X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cardiac myxomas are the most common primary cardiac tumors and are typically attached to the interatrial septum. Left ventricular myxomas are exceedingly rare and presentation in children is all the more uncommon. We report a case of left ventricular myxoma with very atypical cystic appearance raising an initial suspicion of a hydatid cyst. Subsequently, cardiac magnetic resonance imaging was done, which ruled out the diagnosis of hydatid cyst. Complete surgical excision was done through transaortic and transmitral route. Histopathological examination revealed it to be a cardiac myxoma with vascular proliferation, which on echocardiography had appeared as a polycystic lesion. This is a very unusual histopathological presentation of cardiac myxoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1177/2150135117742626

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[PMID]: 29495120
[Au] Autor:Xie X; Bai J
[Ad] Address:Department of Cardiovascular Surgery, Affiliated Hospital Of Southwest Medical University, Luzhou, China.
[Ti] Title:Right atrial myxoma induced right ventricular inflow obstruction.
[So] Source:J Card Surg;, 2018 Mar 01.
[Is] ISSN:1540-8191
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1111/jocs.13550

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[PMID]: 29491306
[Au] Autor:Hamada M; Ogimoto A; Shigematsu Y
[Ad] Address:Division of Cardiology, Uwajima City Hospital, Japan.
[Ti] Title:Transmitral Doppler Flow Pattern in Left Atrial Myxoma.
[So] Source:Intern Med;, 2018 Feb 28.
[Is] ISSN:1349-7235
[Cp] Country of publication:Japan
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.2169/internalmedicine.0456-17

  6 / 8030 MEDLINE  
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[PMID]: 29390296
[Au] Autor:Liu Q; Tong D; Liu G; Yi Y; Zhang D; Zhang J; Zhang Y; Huang Z; Li Y; Chen R; Guan Y; Yi X; Jiang J
[Ad] Address:Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
[Ti] Title:Carney complex with PRKAR1A gene mutation: A case report and literature review.
[So] Source:Medicine (Baltimore);96(50):e8999, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Carney complex (CNC) is a multiple neoplasia syndrome with autosomal dominant inheritance. CNC is characterized by the presence of myxomas, spotty skin pigmentation, and endocrine overactivity. No direct correlation has been established between disease-causing mutations and phenotype. PATIENT CONCERNS: A 16-year-old boy was admitted because of excessive weight gain over 3 years and purple striae for 1 year. Physical examination revealed Cushingoid features and spotty skin pigmentation on his face, lip, and sclera. DIAGNOSES: The patient was diagnosed as Carney complex. INTERVENTIONS: the patient underwent right adrenalectomy and partial adrenalectomy of the left adrenal gland. OUTCOME: Results of imaging showed bilateral adrenal nodular hyperplasia, multiple microcalcifications of the bilateral testes, and compression fracture of the thoracolumbar spine. Histopathological results confirmed multiple pigmented nodules in the adrenal glands. DNA sequencing revealed a nonsense mutation in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A; c.205C > T). After the second adrenalectomy, the Cushingoid features disappeared, and cortisol levels returned to normal. LESSONS: Carney complex is a rare disease that lacks consistent genotype-phenotype correlations. Our patient, who carried a germline PRKAR1A nonsense mutation (c.205C > T), clinical features included spotty skin pigmentation, osteoporosis, and primary pigmented nodular adrenal disease. Adrenalectomy is the preferred treatment for Cushing syndrome due to primary pigmented nodular adrenal disease.
[Mh] MeSH terms primary: Carney Complex/genetics
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/genetics
Mutation/genetics
[Mh] MeSH terms secundary: Adolescent
Adrenalectomy
Carney Complex/diagnosis
Carney Complex/surgery
Diagnosis, Differential
Humans
Male
Polymerase Chain Reaction
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Cyclic AMP-Dependent Protein Kinase RIalpha Subunit); 0 (PRKAR1A protein, human)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008999

  7 / 8030 MEDLINE  
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[PMID]: 29303459
[Au] Autor:Penn DL; Lanpher AB; Klein JM; Kozakewich HPW; Kahle KT; Smith ER; Orbach DB
[Ad] Address:Departments of 1 Neurosurgery.
[Ti] Title:Multimodal treatment approach in a patient with multiple intracranial myxomatous aneurysms.
[So] Source:J Neurosurg Pediatr;21(3):315-321, 2018 Mar.
[Is] ISSN:1933-0715
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The most common primary cardiac tumor is myxoma, typically originating in the left atrium. Emboli to the central nervous system can cause cerebral infarction or, rarely, seed tumor growth within vessel walls, causing myxomatous aneurysms. Fewer than 60 myxomatous aneurysms have been reported, including 2 cases in children. Here, the authors describe 2 different growing myxomatous aneurysms in a child successfully managed using a combined multidisciplinary approach. A 12-year-old boy developed a sudden headache, diplopia, gait instability, and speech difficulty. Magnetic resonance imaging revealed a left parietal hemorrhage and multifocal cerebral infarction, suspicious for an embolic etiology. A cardiac myxoma was identified in the left atrium and resected. Follow-up cranial vasculature imaging demonstrated multiple intracranial myxomatous aneurysms. These lesions were followed up, and serial imaging identified marked growth of 2 of them (right occipital and left parietal), prompting invasive intervention. The deep occipital lesion was better suited to endovascular treatment, while the superficial parietal lesion was amenable to resection. The patient underwent embolization of an enlarging fusiform aneurysm of the distal right posterior cerebral artery, followed by a left parietal craniotomy for a lesion of the distal left middle cerebral artery. Both procedures were performed without complications and achieved successful obliteration of the lesions, as confirmed by catheter angiography at the 30-month follow-up. To the authors' knowledge, this report illustrates the first combined endovascular and open surgical treatment of 2 myxomatous aneurysms in a single patient. While acknowledging the rarity of this condition, this report illustrates the clinical manifestations and treatment challenges posed by myxoma and details a successful strategy that could be employed in similar scenarios.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:In-Data-Review
[do] DOI:10.3171/2017.9.PEDS17288

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[PMID]: 29488004
[Au] Autor:Ostertag H; Glombitza S
[Ad] Address:Pathologisches Institut, Klinikum Region Hannover, Haltenhoffstraße 41, 30167, Hannover, Deutschland. helmut.ostertag@krh.eu.
[Ti] Title:Die aktivierende GNAS-Mutation : Eine Bestandsaufnahme bei der Fibrösen Dysplasie, der ihr assoziierten Syndrome sowie weiterer skelettaler und extraskelettaler Läsionen. [The activating GNAS mutation : A survey of fibrous dysplasia, its associated syndromes, and other skeletal and extraskeletal lesions].
[So] Source:Pathologe;, 2018 Feb 27.
[Is] ISSN:1432-1963
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Fibrous dysplasia of bone is a connatal but not hereditary disease with monostotic or polyostotic manifestations and may be associated either with the extraskeletal disease McCune-Albright syndrome or with myxoma of the skeletal muscle, termed Mazabraud syndrome.The confirmation of recurrent chromosomal aberrations may lead to the conclusion that fibrous dysplasia is a neoplasia rather than a dysplastic skeletal disease.The primary cause of all forms of the described diseases is the activating GNAS mutation, which is detectable in almost all lesions. Research into the impact of this mutation has increased the understanding of these up to now solely descriptively defined diseases and also allowed easier discrimination of various fibro-osseous skeletal lesions. Current insights suggest that this mutation may also play a pivotal role in other extraskeletal neoplasias.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:Publisher
[do] DOI:10.1007/s00292-018-0417-y

  9 / 8030 MEDLINE  
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[PMID]: 29296167
[Au] Autor:Tutman JJ; Rao AG; Hill JG; Crowley CD
[Ad] Address:Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
[Ti] Title:Renal myxoma in a pediatric transplant recipient.
[So] Source:J Radiol Case Rep;11(11):20-27, 2017 Nov.
[Is] ISSN:1943-0922
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Renal myxoma is a very rare benign neoplasm seen almost exclusively in adults with only 16 reported cases in the literature. All of these cases have been reported in native kidneys with none being reported in a transplant kidney. We report the case of a renal myxoma in a 17-year-old boy's transplant kidney that was found as an incidental mass on ultrasonography and further evaluated with CT and PET scans. PET findings of a renal myxoma are reported here for the first time, and imaging findings from previous cases are briefly reviewed. This case report highlights the fact that adult-predominant tumors and pathology should always be a consideration in pediatric patients who receive organ transplants from adult donors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.3941/jrcr.v11i11.3180

  10 / 8030 MEDLINE  
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[PMID]: 29483466
[Au] Autor:Akiyama D; Okada H; Ando T; Takeda M
[Ad] Address:Department of Cardiovascular Surgery, Yokohama Rosai Hospital, Yokohama, Japan.
[Ti] Title:[Asymptomatic Cardiac Myxoma Complicated with Carney Complex;Report of a Case].
[So] Source:Kyobu Geka;71(2):120-123, 2018 Feb.
[Is] ISSN:0021-5252
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:Carney complex(CNC) is a rare genetic syndrome, characterized by spotty pigmentation of the skin, cardiac myxomas and multiple endocrine tumors. We present a case of asymptomatic cardiac myxoma associated with CNC. She was 49 year-old healthy woman whose son was known to have CNC. She was also diagnosed as CNC due to her family history, typical cutaneous findings and screening endocrine test. Screening ultrasound echocardiography resulted in discovering her asymptomatic left atrial myxoma of 30 mm size. Tumor was successfully resected via median sternotomy and no signs of recurrence were observed at 1 year follow up. Periodical follow up is mandatory because of its high recurrence rate.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Data-Review


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