Database : MEDLINE
Search on : Nardostachys [Words]
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[PMID]: 29512454
[Au] Autor:Jalali S; Zarrinhaghighi A; Sadraei S; Ghasemi Y; Sakhteman A; Faridi P
[Ad] Address:Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz. Iran.
[Ti] Title:A Systems Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi.
[So] Source:Curr Drug Metab;, 2018 Mar 05.
[Is] ISSN:1875-5453
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Background The plant Nardostachys jatamansi from Valerianaceae family is a well known antidepressant plant and has historically been used in traditional medicine. As N. jatamansi contains many different compounds, to identify its mechanisms of action, we need a network-based study. Network-based studies are becoming an increasingly important tool in understanding the mechanisms of actions of drugs. Systems pharmacology (SP) and bioinformatics are two emerging tools that use computation to develop an understanding of drug actions in molecular and cellular levels. SP can provide mechanistic understanding of protein-protein (drug-target) interaction involved in a common biological pathway. Objectives The present study was undertaken to identify unknown targets and mechanisms of antidepressant activity of N. jatamansi according to a systems pharmacology approach. Methods First of all a list of all the targets (receptors and metabolites) involved in depression process were provided based on KEGG database. The 3D structures of protein targets were collected as PDB files and their active sites coordinates were found. In the next step the structures of known compounds of N. jatamansi were collected. For identifying the protein-lagand interactions, a docking process was run in AutoDock and an output was received. To complete our study, the similarity between antidepressant conventional drugs and N. jatamansi compounds was analyzed. A SP map figured by Cytoscape Software, shows the relations between herbal compounds, molecular targets and depression. Results According to the docking results, we can suggest several important targets that we have no drugs for, or several natural compounds that play an important role in depression process. According to the similarity results we can suggest several molecules for extraction or synthesis that need more researches for their therapeutic effects. Conclusion This study shows that how N. jatamansi can effect on depression by multiple molecular targeting with multiple compounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.2174/1389200219666180305151011

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[PMID]: 29221883
[Au] Autor:Yoon CS; Kim KW; Lee SC; Kim YC; Oh H
[Ad] Address:College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.
[Ti] Title:Anti-neuroinflammatory effects of sesquiterpenoids isolated from Nardostachys jatamansi.
[So] Source:Bioorg Med Chem Lett;28(2):140-144, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Two new nardosinone-type sesquiterpenoids, namely kanshone J (1) and kanshone K (2) along with seven known terpenoids (3-9) were isolated from the rhizomes and roots of Nardostachys jatamansi DC (Valerianaceae). The structures of these compounds were determined mainly by analysis of 1D-, 2D-NMR and MS data. In addition, the absolute configuration of compound 1 was assigned by application of the modified Mosher's method. In an initial assay to evaluate their anti-neuroinflammatory effects, compounds 1-5 and 9 exhibited dose-dependent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 cells, with IC values ranging from 2.43 to 46.54 µM. Particularly, desoxo-narchinol A (3) and narchinol B (4) significantly inhibited LPS-induced NO overproduction in BV2 cells with IC values of 3.48 ±â€¯0.47 and 2.43 ±â€¯0.23 µM, respectively. Furthermore, compounds 3 and 4 exhibited anti-neuroinflammatory effects by inhibiting the production of pro-inflammatory mediators, including prostaglandin E (PGE ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, and pro-inflammatory cytokines, such as interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α (TNF)-α, in LPS-stimulated BV2 and primary microglial cells.
[Mh] MeSH terms primary: Anti-Inflammatory Agents, Non-Steroidal/pharmacology
Nardostachys/chemistry
Sesquiterpenes/pharmacology
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents, Non-Steroidal/chemistry
Anti-Inflammatory Agents, Non-Steroidal/isolation & purification
Dose-Response Relationship, Drug
Lipopolysaccharides/antagonists & inhibitors
Lipopolysaccharides/pharmacology
Mice
Molecular Structure
Nitric Oxide/antagonists & inhibitors
Nitric Oxide/biosynthesis
Sesquiterpenes/chemistry
Sesquiterpenes/isolation & purification
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lipopolysaccharides); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171210
[St] Status:MEDLINE

  3 / 127 MEDLINE  
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[PMID]: 29398668
[Au] Autor:Liu QF; Jeon Y; Sung YW; Lee JH; Jeong H; Kim YM; Yun HS; Chin YW; Jeon S; Cho KS; Koo BS
[Ad] Address:Department of Oriental Medicine, Dongguk University.
[Ti] Title:Nardostachys jatamansi DC ethanol extract ameliorates Aß42 cytotoxicity.
[So] Source:Biol Pharm Bull;, 2018 Feb 03.
[Is] ISSN:1347-5215
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:The Nardostachys jatamansi DC (NJ) root has been used as a sedative or analgesic to treat neurological symptoms and pain in traditional Korean medicine. Here, we investigate the potential effects of NJ on Alzheimer's disease (AD) and reveal the molecular mechanism through which NJ exerts its effects. The neuroprotective effect of the NJ root ethanol extract against ß amyloid (Aß) toxicity was examined in vitro using a cell culture system and in vivo using a Drosophila AD model. The NJ extract and chlorogenic acid, a major component of NJ, inhibited Aß-induced cell death in SH-SY5Y cells. Moreover, the NJ extract rescued the neurological phenotypes of the Aß42-expressing flies (decreased survival and pupariation rate and a locomotor defect) and suppressed Aß42-induced cell death in the brain. We also found that NJ extract intake reduced glial cell number, reactive oxygen species level, extracellular-signal-regulated kinase (ERK) phosphorylation, and nitric oxide level in Aß42-expressing flies, without affecting Aß accumulation. These data suggest that the neuroprotective activity of NJ might be associated with its antioxidant and anti-inflammatory properties, as well as its inhibitory action against ERK signaling; thus, NJ is a promising medicinal plant for the development of AD treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[St] Status:Publisher
[do] DOI:10.1248/bpb.b17-00750

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[PMID]: 29202512
[Au] Autor:Zhang W; Nan G; Wu HH; Jiang M; Li TX; Wang M; Gao XM; Zhu Y; Song YS; Wang J; Xu YT
[Ad] Address:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
[Ti] Title:A Simple and Rapid UPLC-PDA Method for Quality Control of Nardostachys jatamansi.
[So] Source:Planta Med;, 2017 Dec 04.
[Is] ISSN:1439-0221
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of . Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in . For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of samples from different retail sources. Six of the common peaks ( , and  -  ) were identified as desoxo-narchinol A, buddleoside, isonardosinone, nardosinone, kanshone H, and (-)-aristolone, respectively, by phytochemical investigation. Five of the six compounds significantly either enhanced or inhibited serotonin transporter activity, while (-)-aristolone ( ) didn't show any serotonin transporter activity. In quantitative analysis, the six compounds showed good linearity ( > 0.999) within test ranges. The precision, expressed as relative standard deviation, was in the range of 0.25 - 2.77%, and the recovery of the method was in the range of 92 - 105%. The UPLC-photodiode array detection-based fingerprint analysis and quantitative methods reported here could be used for routine quality control of .
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171204
[Lr] Last revision date:171204
[St] Status:Publisher
[do] DOI:10.1055/s-0043-123655

  5 / 127 MEDLINE  
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[PMID]: 29118341
[Au] Autor:Chen YP; Ying SS; Zheng HH; Liu YT; Wang ZP; Zhang H; Deng X; Wu YJ; Gao XM; Li TX; Zhu Y; Xu YT; Wu HH
[Ad] Address:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
[Ti] Title:Novel serotonin transporter regulators: Natural aristolane- and nardosinane- types of sesquiterpenoids from Nardostachys chinensis Batal.
[So] Source:Sci Rep;7(1):15114, 2017 Nov 08.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Serotonin transporter (SERT) is a classic target of drug discovery for neuropsychiatric and digestive disorders, and against those disorders, plants of Nardostachys genus have been valued for centuries in the systems of Traditional Chinese Medicine, Ayurvedic and Unani. Herein, chemical investigation on the roots and rhizomes of Nardostachys chinensis Batal. led to the isolation of forty sesquiterpenoids including six new aristolane-type sesquiterpenoids and six new nardosinane-type sesquiterprenoids. Their structures were elucidated by extensive spectroscopic methods, combined with analyses of circular dichroism and single-crystal X-ray diffraction data. To explore natural product scaffolds with SERT regulating activity, a high-content assay for measurement of SERT function in vitro was conducted to evaluate the SERT regulating properties of these isolates. In conclusion, eleven compounds could be potential natural product scaffolds for developing drug candidates targeting SERT. Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT potently.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171119
[Lr] Last revision date:171119
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-15483-6

  6 / 127 MEDLINE  
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[PMID]: 28979324
[Au] Autor:Memariani Z; Hajimahmoodi M; Minaee B; Khodagholi F; Yans A; Rahimi R; Amin G; Moghaddam G; Toliyat T; Sharifzadeh M
[Ad] Address:Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Title:Protective Effect of a Polyherbal Traditional Formula Consisting of Mill., L. And DC., Against Ethanol-induced Gastric Ulcer.
[So] Source:Iran J Pharm Res;16(2):694-707, 2017.
[Is] ISSN:1735-0328
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:"VARD" formula consisting of Mill. (Rosaceae) petals, and rhizomes of L. (Papilionaceae) and DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular functions of extracts were also evaluated. Each plant hydroalcoholic extract was standardized via determination of total phenolic and flavonoid contents, also via some phenolic compounds determination and specially glycyrrhizic acid in by using HPLC. Rats received orally extracts of the plants (20, 40 and 80 mg/Kg) and "VARD" (45 mg/Kg) 1 h before ethanol administration. Two h after receiving ethanol, animals were sacrificed; the stomach was removed for macroscopic and microscopic assessment. Also heme-oxygenase-1, glutathione, and catalase were measured in the gastric tissue of the rats pretreated by "VARD" and dose of 20 mg/Kg of extracts. Among three extracts, and contained more total phenolic and flavonoid content respectively. Gallic acid was prominent compound in The extracts of , , and significantly decreased ulcer index. ED values were 8.2, 31.86 and 25.08 mg/Kg respectively. "VARD" significantly decreased ulcer index compared to 20 mg/Kg of ( < 0.0001) and ( < 0.001). Pretreatment with "VARD" and each plant extracts (20 mg/Kg) increased glutathione, catalse and heme-oxygenase-1 significantly ( < 0.05 in comparison with control group. Our findings indicate that "VARD" partly via antioxidant activity can be considered as an effective antiulcer formula.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171008
[Lr] Last revision date:171008
[St] Status:PubMed-not-MEDLINE

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[PMID]: 28851456
[Au] Autor:Moein E; Hajimehdipoor H; Toliyat T; Choopani R; Hamzeloo-Moghadam M
[Ad] Address:Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Title:Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method.
[So] Source:Daru;25(1):19, 2017 Aug 29.
[Is] ISSN:2008-2231
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Currently, people are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. In the present investigation, a poly herbal medicine "Ayarij-e-Faiqra" (AF) based on Iranian traditional medicine (ITM) has been formulated and its quality control parameters have been developed. METHODS: The main ingredients of AF including barks of Cinnamomum zeylanicum Blume and Cinnamomum cassia J. Presl, the rhizomes of Nardostachys jatamansi DC., the fruits of Piper cubeba L.f., the flowers of Rosa damascena Herrm., the oleo gum resin of Pistacia terebinthus L. and Aloe spp. dried juice were powdered and used for preparing seven tablet formulations of the herbal mixture. Flowability of the different formulated powders was examined and the best formulations were selected (F6&F7). The tablets were prepared from the selected formulations compared according to the physical characteristics and finally, F7 was selected and coated. Physicochemical characters of core and coated AF tablets were determined and the HPLC method for quantitation of aloin as a marker of tablets was selected and verified according to selectivity, linearity, precision, recovery, LOD and LOQ. RESULTS: The results showed that core and coated AF tablets were in agreement with USP requirements for herbal drugs. They had acceptable appearance, disintegration time, friability, hardness, dissolution behavior, weight variation and content uniformity. The amount of aloin in tablets was found 123.1 mg/tab. The HPLC method for aloin determination in AF tablets was verified according to selectivity, linearity (5-500 µg/ml, r :0.9999), precision (RSD: 1.62%), recovery (108.0%), LOD & LOQ (0.0053 & 0.0161 µg/ml). CONCLUSIONS: The formulated tablets could be a good substitute for powder and capsules of AF in ITM clinics with a feasible and precise method for its quality control. Ayarij-e-Faiqra formulation.
[Mh] MeSH terms primary: Aloe
Medicine, Traditional
Phytotherapy
[Mh] MeSH terms secundary: Cinnamomum
Drug Compounding
Emodin/analogs & derivatives
Emodin/analysis
Emodin/therapeutic use
Flowers
Fruit
Herbal Medicine/methods
Iran
Medicine, Traditional/methods
Nardostachys
Phytotherapy/methods
Piper
Pistacia
Plant Bark
Rhizome
Rosa
Tablets/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Tablets); KA46RNI6HN (Emodin); W41H6S09F4 (alloin)
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[Js] Journal subset:IM
[Da] Date of entry for processing:170831
[St] Status:MEDLINE
[do] DOI:10.1186/s40199-017-0185-x

  8 / 127 MEDLINE  
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[PMID]: 28797251
[Au] Autor:Li M; Xu X; Yang X; Kwong JSW; Shang H
[Ad] Address:Key laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
[Ti] Title:The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments.
[So] Source:BMC Complement Altern Med;17(1):398, 2017 Aug 10.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. METHODS: To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. RESULTS: A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels (I , I , I , I , I ). CONCLUSION: The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies.
[Mh] MeSH terms primary: Anti-Arrhythmia Agents/pharmacology
Arrhythmias, Cardiac/drug therapy
Heart/drug effects
Myocardium
Nardostachys
Phytotherapy
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Animals
Apoptosis
Arrhythmias, Cardiac/metabolism
Cardiovascular Diseases/drug therapy
Humans
Inflammation/prevention & control
Ion Channels/metabolism
Myocardium/metabolism
Myocardium/pathology
Oxidative Stress
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anti-Arrhythmia Agents); 0 (Ion Channels); 0 (Plant Extracts)
[Em] Entry month:1709
[Cu] Class update date: 170901
[Lr] Last revision date:170901
[Js] Journal subset:IM
[Da] Date of entry for processing:170812
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1910-1

  9 / 127 MEDLINE  
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[PMID]: 28728067
[Au] Autor:Le VNH; Khong TQ; Na MK; Kim KT; Kang JS
[Ad] Address:College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
[Ti] Title:An optimized HPLC-UV method for quantitatively determining sesquiterpenes in Nardostachyos Radix et Rhizoma.
[So] Source:J Pharm Biomed Anal;145:406-413, 2017 Oct 25.
[Is] ISSN:1873-264X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Nardostachyos Radix et Rhizoma (NR), the root and rhizome from either Nardostachys jatamansi Batal or Nardostachys jatamansi DC, is known to have biological functions including neuro-protective and anti-pancreatitis activity. The main bioactive compounds within NR are all classified as sesquiterpenes, and include desoxo-narchinol A, nardosinonediol, and nardosinone. Although NR is a valuable herb that is widely used in many Asian countries, robust quality control protocols for NR are still in question, especially those that can analyze the three main active compounds. Current quantitative methods within the Chinese Pharmacopoeic use nardosinone as a marker compounds. One compound cannot represent a complicated matrix, and is thus insufficient to control the quality of this herbal medicine. Moreover, there are no high-performance liquid chromatography (HPLC) methods that can simultaneously analyze desoxo-narchinol A (DA), nardosinonediol (NE), and nardosinone (ND) within NR. This study aimed to establish an efficient quality control protocol by developing an analytical method that simultaneously detects the three sesquiterpenes with HPLC using response surface methodology (RSM) to optimize sample preparation. Optimized HPLC conditions included a mobile phase of 0.1% formic acid in water (A), and a 0.1% formic acid in acetonitrile (B) under an elution program of 20% B-80% B for 30min at 254nm. The method was well validated, demonstrating satisfactory linearity, accuracy, precision, recovery, repeatability, and stability. Optimized conditions for creating the analytical sample were predicted by RSM using a Box-Behnken design. These conditions included reflux at 70°C for 3h using 24.98% ethanol as the extraction solvent (solvent: solid ratio=78.81mL/g). The relationship between the results between predicted and experimental conditions was well correlated, and varied between 96.48%-102.11%. Thus, our developed HPLC method, paired with optimized sample preparation conditions, accurately quantified all three sesquiterpenes, and may thus be a prospective means of controlling the quality of NR.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[St] Status:In-Process

  10 / 127 MEDLINE  
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[PMID]: 28390974
[Au] Autor:Shen XY; Yu Y; Chen GD; Zhou H; Luo JF; Zuo YH; Yao XS; Dai Y
[Ad] Address:College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
[Ti] Title:Six new sesquiterpenoids from Nardostachys chinensis Batal.
[So] Source:Fitoterapia;119:75-82, 2017 Jun.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Six new sesquiterpenoids, namely nardosinanones J-N and nardoaristolone C, were isolated from the rhizomes and roots of Nardostachys chinensis Batal. Their structures were determined by interpretation of spectroscopic data (HR-ESI-MS, 1D and 2D NMR). A combination of X-ray crystal diffraction, ECD calculation, and Mosher ester methods was employed to determine the absolute configuration of the isolated compounds. Compounds 1-2, 4-6 were evaluated anti-inflammatory activities in LPS-stimulated RAW264.7 macrophages. The results showed that compound 5 obviously inhibited LPS-induced iNOS and COX-2 protein expression compared to single LPS stimulation, which indicated the potential effect to medicate anti-inflammatory.
[Mh] MeSH terms primary: Anti-Inflammatory Agents/chemistry
Nardostachys/chemistry
Sesquiterpenes/chemistry
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents/isolation & purification
Cyclooxygenase 2/metabolism
Macrophages/drug effects
Mice
Molecular Structure
Nitric Oxide Synthase Type II/metabolism
Plant Roots/chemistry
RAW 264.7 Cells
Rhizome/chemistry
Sesquiterpenes/isolation & purification
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents); 0 (Sesquiterpenes); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Entry month:1706
[Cu] Class update date: 170615
[Lr] Last revision date:170615
[Js] Journal subset:IM
[Da] Date of entry for processing:170410
[St] Status:MEDLINE


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