Database : MEDLINE
Search on : Near and Drowning [Words]
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[PMID]: 29504652
[Au] Autor:Beckman K; Mittendorfer-Rutz E; Waern M; Larsson H; Runeson B; Dahlin M
[Ad] Address:Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
[Ti] Title:Method of self-harm in adolescents and young adults and risk of subsequent suicide.
[So] Source:J Child Psychol Psychiatry;, 2018 Mar 05.
[Is] ISSN:1469-7610
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Self-harm is common in youth and an important risk factor for suicide. Certain self-harm methods might indicate a higher risk of suicide. The main aim of this study was to determine whether some methods of self-harm in adolescents (10-17 years) and young adults (18-24 years) are associated with a particularly high risk of suicide. A secondary aim was to ascertain how different self-harm methods might affect the probability of psychiatric follow-up. METHOD: Five Swedish registers were linked in a national population-based cohort study. All nonfatal self-harm events recorded in specialist health care, excluding psychiatry and primary care services, among 10-24 year olds between 2000 and 2009 were included. Methods were classified as poisoning, cutting/piercing, violent method (gassing, hanging, strangulation/suffocation, drowning, jumping and firearms), other and multiple methods. Hazard Ratios (HR) for suicide were calculated in Cox regression models for each method with poisoning as the reference. Odds Ratios (OR) for psychiatric inpatient care were determined in logistic regression models. Analyses were adjusted for important covariates and stratified by age group and treatment setting (inpatient/outpatient). RESULTS: Among adolescents with initial medical hospitalisation, use of a violent method was associated with a near eightfold increase in HR for suicide compared to self-poisoning in the adjusted analysis [HR 7.8; 95% confidence interval (CI) 3.2-19.0]. Among hospitalised young adult women, adjusted HRs were elevated fourfold for both cutting [4.0 (1.9-8.8)] and violent methods [3.9 (1.5-10.6)]. Method of self-harm did not affect suicide risk in young adult men. Adolescents using violent methods had an increased probability of psychiatric inpatient care following initial treatment for self-harm. CONCLUSIONS: Violent self-harm requiring medical hospitalisation may signal particularly high risk of future suicide in adolescents (both sexes) and in young adult women. For the latter group this is the case for cutting requiring hospitalisation as well.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1111/jcpp.12883

  2 / 1315 MEDLINE  
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[PMID]: 29491040
[Au] Autor:Lelievre B; Briet M; Godon C; Legras P; Riou J; Vandeputte P; Diquet B; Bouchara JP
[Ad] Address:Angers university hospital; belelievre@chu-angers.fr.
[Ti] Title:Impact of infection status and cyclosporine on voriconazole pharmacokinetics in an experimental model of cerebral scedosporiosis.
[So] Source:J Pharmacol Exp Ther;, 2018 Feb 28.
[Is] ISSN:1521-0103
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cerebral Scedosporium infections usually occur in lung transplant recipients as well as in immunocompetent patients in the context of near-drowning. Voriconazole is the first-line treatment. The diffusion of voriconazole through the blood-brain barriers in the context of cerebral infection and cyclosporine administration is crucial and remains a matter of debate. To address this issue, the pharmacokinetics of voriconazole were assessed in the plasma, cerebrospinal fluid (CSF), and brain, in an experimental model of cerebral scedosporiosis in rats receiving or not cyclosporine. A single dose of voriconazole (30 mg/kg, i.v.) was administrated to six groups of rats randomized according to the infection status and the cyclosporine dosing regimen (no cyclosporine, a single dose or three doses 15 mg/kg each). Voriconazole concentrations in plasma, CSF, and brain samples were quantified using UPLC-MS/MS and HPLC-UV methods and documented up to 48 hours after administration. Pharmacokinetic parameters were estimated using a non-compartmental approach. Voriconazole pharmacokinetic profiles were similar for plasma, CSF, and the brain in all groups studied. Voriconazole Cmax and AUC0=>48h were significantly higher in the plasma than in the CSF (CSF/plasma ratio, median [range] = 0.5 [0.39-0.55] for AUC0=>48h and 0.47 [0.35 and 0.75] for Cmax). Cyclosporine administration was significantly associated with an increase in voriconazole exposure in the plasma, CSF, and brain. In the plasma but not in the brain, an interaction between the infection and cyclosporine administration reduced the positive impact of cyclosporine on voriconazole exposure. Together these results emphasize the impact of cyclosporine on the brain voriconazole exposure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher

  3 / 1315 MEDLINE  
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[PMID]: 29452150
[Au] Autor:Lovett ME; Maa T; Chung MG; O'Brien NF
[Ad] Address:Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH, United States. Electronic address: marlina.lovett@nationwidechildrens.org.
[Ti] Title:Cerebral blood flow velocity and autoregulation in paediatric patients following a global hypoxic-ischaemic insult.
[So] Source:Resuscitation;, 2018 Feb 13.
[Is] ISSN:1873-1570
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:AIM: To describe the cerebral blood flow velocity pattern and investigate cerebral autoregulation using transcranial Doppler ultrasonography (TCD) following a global hypoxic-ischaemic (HI) event in children. METHODS: This was a prospective, observational study in a quaternary-level paediatric intensive care unit. Intubated children, newborn to 17 years admitted to the PICU following HI injury (asphyxia, drowning, cardiac arrest) were eligible for inclusion. TCD was performed daily until post-injury day 8, discharge, or death, whichever occurred earliest. RESULTS: Twenty-six patients were enrolled. Median age was 3 years (0.33, 11.75), initial pH 6.95, and initial lactate 5.4. Median post-resuscitation Glasgow Coma Score was 3T. Across the entire cohort, cerebral blood flow velocity (CBFV) was near normal on day 1. Flow velocity increased to a maximum median value of 1.4 standard deviations above normal on day 3 and slowly downtrended back to baseline by the end of the study period. Median Paediatric Extended Version of the Glasgow Outcome Score was 4 at three months. No patient in the favourable outcome group had extreme CBFV on day one, and only one patient in the favourable group had extreme CBFV on PID 2. In contrast, 38% of patients in the unfavourable group had extreme CBFV on PID 1 (p=.039 compared to frequency in favourable group), and 55% had extreme CBFV on PID 2 (p = .023 compared to frequency in favourable group). No patient had consistently intact cerebral autoregulation throughout the study period. CONCLUSIONS: Following a HI event, patients with favourable neurologic outcomes had flow velocity near normal whereas unfavourable outcomes had more extreme flow velocity. Intermittently intact cerebral autoregulation was more frequently seen in those with favourable neurologic outcomes though return to the autoregulatory baseline appears delayed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  4 / 1315 MEDLINE  
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[PMID]: 29406474
[Au] Autor:Cohen N; Scolnik D; Rimon A; Balla U; Glatstein M
[Ti] Title:Childhood Drowning: Review of Patients Presenting to the Emergency Departments of 2 Large Tertiary Care Pediatric Hospitals Near and Distant From the Sea Coast.
[So] Source:Pediatr Emerg Care;, 2018 Feb 05.
[Is] ISSN:1535-1815
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Drowning is a leading cause of death among infants and toddlers. Unique physiological and behavioral factors contribute to high mortality rates. Drowning incidents predominantly occur during warmer months and holidays. The aim of this study was to describe the characteristics of pediatric drowning victims who attended 2 different emergency departments (EDs), 1 near and 1 distant from the sea coast, to recognize risk factors, complications, causes of death, and the educational needs of families and caregivers. METHODS: Retrospective cohort analysis of incident history, clinical presentation, treatments, and outcomes of drowning victims was performed. Data were analyzed both by age group and proximity of institution to the sea coast. RESULTS: From 2005 to 2015, 70 drowning patients presented to the 2 institutions; there was no difference in incident history or outcomes based on proximity to the sea coast. Fifty-six percent of patients were younger than 6 years, the majority drowning in pools. More of the older children drowned in the sea (48% vs 23%). Half of all patients were treated and followed in the ED or ward, and the other half were treated in the pediatric intensive care unit; 12 suffered severe complications, including 5 diagnosed with brain death. Cardiopulmonary resuscitation was performed in 80% of the fatal group and 23% of the nonfatal group (P = 0.006). Seven children who experienced a cardiac arrest with hypothermia were treated before arrival in the ED, and 5 had ongoing cardiac arrest upon arrival in the ED (these were the 5 suffering brain death). DISCUSSION: Most of patients younger than 6 years drowned in swimming pools, suggesting that parents are perhaps less vigilant in these circumstances, even though they may remain in close proximity. Active adult supervision entails attention, proximity, and continuity. Educational efforts should be aimed at reminding parents of this, especially in the summer months.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:Publisher
[do] DOI:10.1097/PEC.0000000000001394

  5 / 1315 MEDLINE  
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[PMID]: 29325087
[Au] Autor:Ruan Q; Liu Q; Yu S; Yang F; Chen S; Zhang W
[Ad] Address:Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai, China.
[Ti] Title:A 60-Year-Old Man With Fever and Headache After a Near-Drowning Event.
[So] Source:Clin Infect Dis;66(2):314-315, 2018 Jan 06.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:In-Data-Review
[do] DOI:10.1093/cid/cix630

  6 / 1315 MEDLINE  
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[PMID]: 29325086
[Ti] Title:A 60-Year-Old Man With Fever and Headache After a Near-Drowning Event.
[So] Source:Clin Infect Dis;66(2):312-313, 2018 Jan 06.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:In-Data-Review
[do] DOI:10.1093/cid/cix628

  7 / 1315 MEDLINE  
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[PMID]: 29172330
[Au] Autor:Sandmeyer J; Heightman AJ
[Ti] Title:Waterlogged. San Diego Fire-Rescue lifeguards faced with MCI in the water.
[So] Source:JEMS;41(8):40-1, 2016 08.
[Is] ISSN:0197-2510
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Emergency Medical Services/organization & administration
Mass Casualty Incidents
Near Drowning/prevention & control
Oceans and Seas
Swimming
[Mh] MeSH terms secundary: Adolescent
California
Female
Humans
Male
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171214
[Lr] Last revision date:171214
[Js] Journal subset:H
[Da] Date of entry for processing:171128
[St] Status:MEDLINE

  8 / 1315 MEDLINE  
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[PMID]: 29149019
[Au] Autor:Cerland L; Mégarbane B; Kallel H; Brouste Y; Mehdaoui H; Resiere D
[Ad] Address:Department of Emergency Medicine, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France. lauracerland@gmail.com.
[Ti] Title:Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.
[So] Source:Int J Environ Res Public Health;14(11), 2017 Nov 17.
[Is] ISSN:1660-4601
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. One hundred and forty-four near-drowning patients (33 children and 111 adults) admitted during four years to the University Hospital of Martinique, French Indies, were included. Patients presented pre-hospital cardiac arrest (41%) and exhibited acute respiratory failure (54%), cardiovascular failure (27%), and lactic acidosis (75%) on admission. Empirical antibiotics, as decided by the physicians in charge, were administered in 85 patients (59%). Post-drowning early onset bacterial pneumonia was diagnosed as "possible" in 13 patients (9%) and "confirmed" in 22 patients (15%). Tracheal aspiration revealed the presence of polymorphous pharyngeal flora (59%) or one predominant bacteria species (41%) including , , , , , and . Despite adequate supportive care, drowning resulted in 45 fatalities (31%). Early onset bacterial aspiration pneumonia (either possible or confirmed) did not significantly influence the risk of death. In conclusion, near-drowning-related bacterial aspiration pneumonia seems rare and does not influence the mortality rate. There is still a need for practice standardization to improve diagnosis of post-drowning pneumonia and near-drowning patient management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:In-Process

  9 / 1315 MEDLINE  
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[PMID]: 29132598
[Au] Autor:Keffeler J; Frank M; Derr C
[Ad] Address:Tampa General Hospital Aeromed, Tampa, FL. Electronic address: Jotham1021@yahoo.com.
[Ti] Title:A 6-Year-Old Male Cold Water Near Drowning Where You Might Least Expect It.
[So] Source:Air Med J;36(6):339-340, 2017 Nov - Dec.
[Is] ISSN:1532-6497
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:In-Data-Review

  10 / 1315 MEDLINE  
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[PMID]: 28817216
[Au] Autor:Owen AM
[Ad] Address:The Brain and Mind Institute, The University of Western Ontario, Canada.
[Ti] Title:Functional neuroimaging after severe anoxic brain injury in children may reveal preserved, yet covert, cognitive function.
[So] Source:Hum Brain Mapp;38(10):4832-4833, 2017 Oct.
[Is] ISSN:1097-0193
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A growing body of evidence has confirmed that, after severe brain injury in adults, motoric and task-dependent factors that are essential for reliable communication, frequently interfere with an accurate assessment of cognitive status. In the current study, resting state functional magnetic resonance imaging (fMRI) in children who have sustained an anoxic brain injury following a near drowning incident suggests a similar pattern; preserved cognition amidst severe motoric impairment that effectively precludes accurate clinical diagnosis at the bedside. Hum Brain Mapp 38:4832-4833, 2017. © 2017 Wiley Periodicals, Inc.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170911
[Lr] Last revision date:170911
[St] Status:In-Process
[do] DOI:10.1002/hbm.23760


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