Database : MEDLINE
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[PMID]: 29524916
[Au] Autor:Lopes H; Mateus C; Rosati N
[Ad] Address:Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Lisbon, Portugal. Electronic address: h.lopes@ensp.unl.pt.
[Ti] Title:Impact of long term care and mortality risk in community care and nursing homes populations.
[So] Source:Arch Gerontol Geriatr;76:160-168, 2018 Feb 20.
[Is] ISSN:1872-6976
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To identify the survival time, the mortality risk factors and the individuals' characteristics associated with cognitive and physical status at discharge, among the Portuguese long-term care (LTC) populations. SETTINGS: Home-and-Community-Based Services (HCBS) and three types of Nursing Homes (NH). PARTICIPANTS: 20,984 individuals admitted and discharged in 2015. MEASUREMENTS: The Kaplan-Meier survival analysis and the Cox Proportional Hazards Models were used to study the mortality risk; the Wilcoxon signed-rank test to identify the number of individuals with cognitive and physical changes between admission and discharge; two cumulative odds ordinal logistic regressions to predict the cognitive and physical dependence levels at discharge RESULTS: The mortality rate at HCBS was 30%, and 17% at the NH, with a median survival time of 173 and 200 days, respectively. The main factors associated with higher mortality were older age, male gender, family/neighbour support, neoplasms and cognitive/physical dependence at admission. In NH/HCBS, 26%/18% of individuals improve their cognitive status, while in physical status the proportion was 38%/27%, respectively. Finally, older age, being illiterate and being classified at the lowest cognitive and physical status at admission decrease the likelihood of achieving a higher level of cognitive and physical independence at discharge. CONCLUSIONS: The adoption of a robust and complete assessment tool, the definition of guidelines to enable a periodical assessment of individuals' autonomy and the adoption of benchmark metrics allowing the comparison of results between similar units are some of the main goals to be taken into account for future developments of this care in Portugal.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 2321357 MEDLINE  
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[PMID]: 29524718
[Au] Autor:Schär RT; Schwarz C; Söll N; Raabe A; Z'Graggen WJ; Beck J
[Ad] Address:Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Switzerland; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: ralph.schaer@insel.ch.
[Ti] Title:Early postoperative perils of intraventricular tumors: An observational comparative study.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Early postoperative patient surveillance after removal of intraventricular tumors is often hindered by delayed awakening and prolonged somnolence. The objective of this study was to analyze the incidence of early critical postoperative events after elective craniotomies for intraventricular tumors in adults as compared to extraventricular lesions. METHODS: An observational comparative study was conducted on adult patients who had undergone first-time elective craniotomies from November 2011 until August 2016. Patients were stratified into extraventricular lesions (group 1) and intraventricular tumors (group 2). The rates of late extubation, early postoperative seizures, emergency head CTs, and urgent surgical intervention within 48 hours and mortality within 30 days of surgery were analyzed from a prospective database. RESULTS: A total of 977 elective craniotomies were analyzed: group 1 (951 patients, 97.3%) vs. group 2 (26, 2.7%). In group 2 emergency CTs were significantly more often ordered (rate 34.6 % vs. 8.4%; OR 5.76, 95% CI 2.49-13.35, p = 0.0002), and the incidence of urgent surgical intervention was significantly higher (rate 11.5% vs. 0.8%; OR 15.38, 95% CI 3.83-61.72, p = 0.002) than in group 1. Main reason for urgent surgical intervention in group 2 was acute obstructive hydrocephalus. Overall surgical mortality after 30 days was 0.3% (3 cases in group 1, no case in group 2). CONCLUSION: Intraventricular tumors are at significantly higher risk for early emergency head CT and urgent surgical intervention. This patient cohort might benefit from routine intra- and early postoperative imaging, as well as intraoperative extraventricular drain placement.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 2321357 MEDLINE  
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[PMID]: 29524505
[Au] Autor:Randall S; Boyd J; Fuller E; Brooks C; Morris C; Earle CC; Ferrante A; Moorin R; Semmens J; Holman CDJ
[Ad] Address:Curtin University, Perth, Western Australia. Electronic address: sean.randall@curtin.edu.au.
[Ti] Title:The effect of vasectomy reversal on prostate cancer risk: International meta-analysis of 684,660 men with vasectomies.
[So] Source:J Urol;, 2018 Mar 07.
[Is] ISSN:1527-3792
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Evidence on the effect of vasectomy on prostate cancer is conflicting, with the issue of detection bias a key criticism. We examine the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomised men; evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk, while nullifying the issue of detection bias. METHODS: Data were sourced from five population-level linked health databases located in Australia, Canada and the United Kingdom. Cox proportional hazards regression analysis compared the risk of prostate cancer in those with vasectomy reversal (n=9,754) to those with a vasectomy but no reversal (n=684,660); data from each jurisdiction were combined in a meta-analysis. RESULTS: The combined analysis showed no protective effect of vasectomy reversal on incidence of prostate cancer when compared to those who had vasectomy alone (HR, 95%CI: 0.92, 0.70-1.21). CONCLUSION: These results align with previous studies that found no evidence of a link between vasectomy and prostate cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 2321357 MEDLINE  
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[PMID]: 29524375
[Au] Autor:Pella D; Fedacko J; Rajnoha R; Gavurová B; Koróny S
[Ad] Address:1st Department of Internal Medicine, Louis Pasteur University Hospital, Pavol Jozef Safárik University in Kosice, Kosice, Slovak Republic.
[Ti] Title:Age-adjusted Mortality Rates of Neoplasms and Circulatory System Diseases and Their Demographic Factors in Slovak Regions during 1996-2013.
[So] Source:Cent Eur J Public Health;25 Suppl 2:S86-S93, 2017 Dec.
[Is] ISSN:1210-7778
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:AIM: Knowledge of the causes of deaths in Slovakia is lacking. This is significant because diet and lifestyle factors are different in central Europe compared to Western, Northern and Southern Europe. This study aims to discern trends of age-adjusted mortality rates caused by various diseases in relation to demographic factors. The aim of our study was to find certain statistical aspects including trends of age-adjusted mortality rates caused by neoplastic (Chapter II) and circulatory diseases (Chapter IX) in the Slovak population in relation to available demographic factors (sex, region and calendar year of death). METHODS: Dataset of individual deaths in Slovakia with certain demographic factors (sex, region and calendar year of death) during 1996-2013 were provided by the Slovak National Center of Health Informatics. Regression and correlation analyses and analyses of variance and of covariance were used to yield the level of significance. RESULTS: We found significant differences of age-adjusted mortality rates between men and women, between Chapter II and Chapter IX and among Slovak regions. Age-adjusted mortality rates decline significantly in most regions for both sexes with the exception of stagnation in four regions in a group of Chapter II women (Kosice, Nitra, Trencín and Zilina) and one region in Chapter IX, also in group of women (Zilina). CONCLUSIONS: Mortalities caused either by Chapter II or Chapter IX diseases are significantly dependent on chapter, sex and region with mortalities either declining or stagnating.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.21101/cejph.a5056

  5 / 2321357 MEDLINE  
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[PMID]: 29524374
[Au] Autor:Gavurová B; Koróny S; Soltés M
[Ad] Address:Faculty of Economics, Technical University of Kosice, Kosice, Slovak Republic.
[Ti] Title:Influence of Demographic Factors on Standardised Rate Ratio of Age-adjusted Mortality Rates of Men in Comparison with Women Caused by Neoplasms and Circulatory System Diseases in Slovak Regions during 1996-2013.
[So] Source:Cent Eur J Public Health;25 Suppl 2:S80-S85, 2017 Dec.
[Is] ISSN:1210-7778
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:AIM: The aim of our study was to find statistical associations including trends of standardised rate ratio of age-adjusted mortality rates for the male population as compared to the female population, in relation to available demographic factors (Chapter II - Neoplasms vs. Chapter IX - Diseases of the circulatory system, Slovak region and calendar year of death). METHODS: Dataset of individual cases of death in Slovakia with some demographic factors during 1996-2013 were provided by Slovak National Health Information Center. We used regression and correlation analyses, as well as analyses of variance and covariance along with descriptive statistics. RESULTS: The standardised rate ratio of age adjusted mortality rates of men versus age-adjusted mortality rates of women differs between Chapter II and Chapter IX (mean 2.08 vs. 1.35, p<0.001). There are also significant differences of standardised rate ratio among regions (p<0.05). Trends show that the standardised rate ratio has significant regional decline for Chapter II: Kosice (p<0.01), Trencín (p<0.001) and Zilina (p<0.05) whereas in Chapter IX Zilina region (p<0.01) is implicated. In other Slovak regions standardised rate ratio stagnates. CONCLUSIONS: Standardised rate ratios of age-adjusted mortality rates for the male population compared to the female population are significantly dependent on chapter, sex and region. Standardised rate ratios either decline or stagnate.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.21101/cejph.a5057

  6 / 2321357 MEDLINE  
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[PMID]: 29524373
[Au] Autor:Fedacko J; Pella D; Gavurová B; Koróny S
[Ad] Address:1st Department of Internal Medicine, Louis Pasteur University Hospital, Pavol Jozef Safárik University in Kosice, Kosice, Slovak Republic.
[Ti] Title:Influence of Demographic Determinants on the Number of Deaths Caused by Circulatory System Diseases in Comparison to the Number of Deaths Caused by Neoplasms in Slovak Regions from 1996-2014.
[So] Source:Cent Eur J Public Health;25 Suppl 2:S72-S79, 2017 Dec.
[Is] ISSN:1210-7778
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The objective of our study was to evaluate the influence of available demographic determinants on the number of deaths caused by circulatory system diseases as compared to deaths caused by neoplasms in Slovakia in 1996-2014. METHODS: Mortality data were kindly provided by the National Health Information Centre in Slovakia. The first method was trend curve fitting of death ratios caused by circulatory system diseases (Chapter IX) and of deaths caused by neoplasms (Chapter II) as a function of age for both sexes. The second method comprised a decision tree for classification between deaths caused by Chapter IX and Chapter II diseases. Input variables were available demographic indicators: age, sex, marital status, region, and calendar year of death. Statistical data analyses were performed by IBM SPSS version 19 statistical software. RESULTS: We found that the odds ratios of deaths caused by circulatory system diseases (Chapter IX) in comparison with deaths caused by neoplasms (Chapter II) were non-decreasing. At first, the values of odds ratios are constant until they reach a critical sex-dependent value with a subsequent steady increase. In the case of men the odds ratio was greater than in the 60 years age-group where the odds ratio value increased slowly (from 1.14 at age 60 to 7.25 at age 90 years). The relative increase was 6.36 (7.25/1.14). The odds ratio in the women group was smaller but increased more rapidly (from 0.81 at age 60 to 12.27 at age 90 years). The relative increase was 15.15 in women (12.27/0.81). Hence, the odds ratio of death caused by Chapter IX diseases vs. Chapter II was greater in the older women group (i.e. higher age values). Utilizing the decision tree model, we have found that the most significant demographic determinant of death counts in both ICD Chapters was the age of the deceased, followed by marital status and finally gender. The last two predictors (year and region) were relatively negligible though formally significant. CONCLUSIONS: The proposed method could be useful for prognostic classification of patients and primarily beneficial for hospitals in human or financial resources planning.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.21101/cejph.a5053

  7 / 2321357 MEDLINE  
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[PMID]: 29524368
[Au] Autor:Kubák M; Stefko R; Barták M; Majerník J; Vagasová T; Fedelesová M
[Ad] Address:Faculty of Economics, Technical University of Kosice, Kosice, Slovak Republic.
[Ti] Title:Risk of Dying from Cancer by Socio-demographic Indicators in the Slovak Republic.
[So] Source:Cent Eur J Public Health;25 Suppl 2:S37-S43, 2017 Dec.
[Is] ISSN:1210-7778
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:AIM: Cancer mortality distribution was investigated by detailed neoplasms groups, age, sex, marital status of deceased, and regions in the Slovak Republic, and examined how these determinants influence the odds of dying due to cancer. METHODS: A retrospective analysis of cancer mortality statistics registered in the Slovak Republic during the years 1996-2014. For this time period, data was available only on the underlying subgroups of cancer deaths, place of death, age, year, sex, and marital status. Binary logistic regression was applied for odds of dying calculation influenced by these socio-demographic factors. RESULTS: The most common are deaths from malignant neoplasms of digestive organs in males as well as females. The biggest difference among both genders is recognized in malignant neoplasms of lip, oral cavity and pharynx, where deaths among males are on average 7.9 times higher in comparison to females. As for place of death the Bratislava region reports the highest level of cancer mortality stated at 25.22% of all deaths, on the contrary the Banská Bystrica region reports only 21.40% of all deaths. Age has a negative influence on odds of dying due to neoplasms compared to all other causes of death by 1.7%. In all regions compared to the reference Bratislava region, the odds of dying from neoplasms are lower. Being female diminishes the odds of dying due to neoplasms by 25.7% compared to males. Yearly the relative ratio of dying from neoplasms increases with respect to all other causes of death. When single people are set as the reference category, the relation of the probability of death from cancer to the probability of death due to other causes of death is higher for married, divorced and widowed persons. CONCLUSIONS: The results should be taken into account when comparing risk of dying due to cancer among people with the mentioned sociodemographic characteristics. Health policy makers should consider place of death and cancer types while planning hospital care units.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.21101/cejph.a5050

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[PMID]: 29524354
[Au] Autor:Wu J; Tian X; Liu B; Li C; Hao C
[Ad] Address:Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, China (mainland).
[Ti] Title:Features and Treatment of Peritoneal Metastases from Solid Pseudopapillary Neoplasms of the Pancreas.
[So] Source:Med Sci Monit;24:1449-1456, 2018 Mar 10.
[Is] ISSN:1643-3750
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND Solid pseudopapillary neoplasms (SPNs) of the pancreas may present widespread peritoneal metastases, but the treatment of this malignancy has not been well described and requires further investigation. MATERIAL AND METHODS Four cases of SPN with significant peritoneal metastases in our department were operated and retrospectively summarized after long-term follow-up. Eight more cases of peritoneal metastatic SPN from the PubMed database were also included in the analysis. RESULTS Peritoneal metastases of SPNs have different gross features. The benign nodules were tenacious and well encapsulated, while the malignant nodules were soft and prone to slow bleeding. However, neither of these nodules invaded the small intestines or mesentery. Of the 12 disseminated cases, 7 had history of primary tumor rupture, whereas the others had tumors malignant in nature. A total of 14 surgical events were documented, including 3 complete cytoreductive surgeries (CCRS), 9 cytoreductive surgeries (CRS), and 2 debulking surgeries. After follow-up ranging from 0.3 to 6.1 years, the results of the Fisher's exact test showed no difference between CCRS and CRS in treating either low-grade or high-grade malignant SPNs (P=0.257 and P=0.203, respectively). For all cases of SPN with peritoneal metastases, the CCRS procedure could significantly improve tumor-free survival (TFS) compared to the CRS procedure (P=0.046). CONCLUSIONS SPN rupture could cause significant peritoneal metastases, and either disruption or biopsy of these lesions should be avoided. Peritoneal metastases from SPNs vary both in gross features and biological mechanisms. CCRS may offer optimal therapeutic outcomes and longer TFS for individuals with significant peritoneal metastases of SPNs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

  9 / 2321357 MEDLINE  
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[PMID]: 29520385
[Au] Autor:Kim SB; Yoon SG; Tae J; Kim JY; Shim JS; Kang SG; Cheon J; Lee JG; Kim JJ; Kang SH
[Ad] Address:Department of Urology, Korea University College of Medicine, Seoul, Korea.
[Ti] Title:Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy.
[So] Source:Investig Clin Urol;59(2):98-105, 2018 Mar.
[Is] ISSN:2466-054X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Purpose: The purpose of this study was to evaluate the efficacy of narrow-band imaging (NBI) as a diagnostic tool for detecting bladder tumors during cystoscopy compared with white light cystoscopy (WLC). Materials and Methods: From December 2013 to June 2017, a randomized prospective study was conducted on 198 patients underwent transurethral resection of bladder tumor by a single surgeon. The patients were divided into two groups according to diagnostic method. In Group I, WLC only was performed. In Group II, NBI was additionally performed after WLC. We analyzed the rate of detection of bladder tumors as a primary endpoint. In addition, we evaluated rates of recurrence in each group. Results: There were no significant differences between the two groups in characteristics except hypertension. In the analysis of rates of detection, the probability of diagnosing cancer was 80.9% (114/141) in the WLC group, and the probability of diagnosing cancer using WLC in the NBI group was 85.5% (159/186). After switching from WLC to NBI for second-look cystoscopy in the NBI group, NBI was shown to detect additional tumors with a detection rate of 35.1% (13/37) from the perspective of the patients and 42.2% (27/64) from the perspective of the tumors. The 1-year recurrence-free rate was 72.2% in the WLC group and 85.2% in the NBI group (p=0.3). Conclusions: NBI had benefits for detecting tumors overlooked by WLC. Although the difference in the 1-year recurrence-free rate was not statistically significant, our results showed a trend for higher recurrence in the NBI group.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.4111/icu.2018.59.2.98

  10 / 2321357 MEDLINE  
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[PMID]: 29520382
[Au] Autor:Piao XM; Byun YJ; Kim WJ; Kim J
[Ad] Address:Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
[Ti] Title:Unmasking molecular profiles of bladder cancer.
[So] Source:Investig Clin Urol;59(2):72-82, 2018 Mar.
[Is] ISSN:2466-054X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.4111/icu.2018.59.2.72


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