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[PMID]: 29382019
[Au] Autor:Wang Y; Li D; Qiao L; Zhao F
[Ad] Address:Department of Pediatric.
[Ti] Title:Infant Central Nervous System Aspergillosis with First-episode of Intracranial Hemorrhage: A case report.
[So] Source:Medicine (Baltimore);96(47):e8893, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Central nervous system (CNS) aspergillosis has the characteristics of multifocality, polymorphism, and coexistence of pathological types, and missed diagnosis and misdiagnosis frequently occur at the initial stage. The thesis reports a rare case of infant infection of CNS aspergillosis with the first-episode of intracranial hemorrhage. PATIENT CONCERNS: An 11-month-old female infant suffered convulsion and coma two days after the onset of fever and emesis. Its cranial computed tomography (CT) displayed subdural hemorrhage in the left tentorium cerebelli and tests indicated normal cerebrospinal fluid (CSF). Three days after being hospitalized, the infant had difficulty breathing and its CT presents consolidation in the right lung. However, treatment with ceftriaxone (ivgtt) had no effect on the baby. DIAGNOSIS: The patient's bronchoalveolar lavage fluid (BALF) was cultured into Aspergillus spp, its galactomannan (GM) antigen in CSF counted 3.0, higher than that in BALF which counted 2.6, and cranial magnetic resonance imaging (MRI) revealed multiple ring reinforced tubercles in sulci. Hence it was clinically diagnosed with CNS aspergillosis. INTERVENTIONS: Voriconazole for intravenous injection. After the intravenous injection, its trough concentration was 4.2 µg/mL, and it was within the recommended range. OUTCOMES: After one week's treatment with voriconazole, the infant's consciousness was improved. Four weeks later, with normothermia and clear consciousness, the patient was discharged. With oral administration of voriconazole up to 16 weeks, its physical state suggests no relapse and cranial MRI indicated disappearance of nodules in sulci. LESSONS: CNS aspergillosis with first-episode of intracranial hemorrhage probably leads to misdiagnosis and GM test combined with cranial MRI can augment its accuracy in the early diagnosis.
[Mh] MeSH terms primary: Central Nervous System Fungal Infections/complications
Intracranial Hemorrhages/parasitology
Neuroaspergillosis/complications
[Mh] MeSH terms secundary: Antifungal Agents/administration & dosage
Central Nervous System Fungal Infections/drug therapy
Humans
Infant
Neuroaspergillosis/drug therapy
Voriconazole/administration & dosage
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); JFU09I87TR (Voriconazole)
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008893

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[PMID]: 27936983
[Au] Autor:McCarthy MW; Walsh TJ
[Ad] Address:a Hospital Medicine , Joan and Sanford I Weill Medical College of Cornell University , New York , NY , USA.
[Ti] Title:Molecular diagnosis of invasive mycoses of the central nervous system.
[So] Source:Expert Rev Mol Diagn;17(2):129-139, 2017 Feb.
[Is] ISSN:1744-8352
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: In September 2012, the Centers for Disease Control and Prevention (CDC) began investigating an outbreak of fungal meningitis among patients who had received contaminated preservative-free methyl prednisolone acetate injections from the New England Compounding Center in Framingham, Massachusetts. Thousands of patients were potentially exposed to tainted corticosteroids, but establishing the diagnosis of fungal meningitis during the nationwide outbreak was difficult because little was known about the natural history of the disease. Areas covered: The challenges associated with this outbreak highlighted the need for rapid and reliable methodologies to assist in the diagnosis of invasive mycoses of the central nervous system (IMCNS), which may be devastating and difficult to treat. In this paper, we review the causative agents of these potentially-lethal infections, which include cryptococcal meningitis, cerebral aspergillosis, and hematogenous Candida meningoencephalitis. Expert commentary: While microscopy, culture, and histopathologic identification of fungal pathogens remain the gold standard for diagnosis, new platforms and species-specific assays have recently emerged, including lateral flow immunoassays (LFA), matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and multiplex PCR in conjunction with magnetic resonance (MR) to potentially aid in the diagnosis of IMCNS.
[Mh] MeSH terms primary: Candidiasis/diagnosis
Disease Outbreaks
Meningitis, Cryptococcal/diagnosis
Meningoencephalitis/diagnosis
Molecular Diagnostic Techniques/methods
Neuroaspergillosis/diagnosis
[Mh] MeSH terms secundary: Candidiasis/epidemiology
Candidiasis/genetics
Drug Contamination
Humans
Meningitis, Cryptococcal/epidemiology
Meningitis, Cryptococcal/genetics
Meningoencephalitis/epidemiology
Meningoencephalitis/genetics
Methylprednisolone/adverse effects
Methylprednisolone/analogs & derivatives
Methylprednisolone/therapeutic use
Neuroaspergillosis/epidemiology
Neuroaspergillosis/genetics
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:43502P7F0P (methylprednisolone acetate); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1710
[Cu] Class update date: 171009
[Lr] Last revision date:171009
[Js] Journal subset:IM
[Da] Date of entry for processing:161213
[St] Status:MEDLINE
[do] DOI:10.1080/14737159.2017.1271716

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[PMID]: 26375027
[Au] Autor:Kim TS; Ahn KS; Kim YH; Kim HT; Jang BK; Hwang JS; Kim IM; Kang YN; Kang KJ
[Ad] Address:From the Department of Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
[Ti] Title:Successful Treatment of Combined Aspergillus and Cytomegalovirus Abscess in Brain and Lung After Liver Transplant for Toxic Fulminant Hepatitis.
[So] Source:Exp Clin Transplant;15(1):110-113, 2017 Feb.
[Is] ISSN:2146-8427
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Invasive aspergillosis is one of the most important and fatal complications after liver transplant, especially in patients with involvement of the central nervous system. We present a case of a patient who developed cerebral and pulmonary aspergillosis, coinfected with cytomegalovirus, after liver transplant for toxic fulminant hepatitis. The patient was treated successfully with neurosurgical intervention and voriconazole. Voriconazole is considered more effective in cerebral aspergillosis than other anti-fungal agents due to the greater penetration into central nervous system and higher cerebrospinal fluid and brain tissue levels.
[Mh] MeSH terms primary: Antifungal Agents/therapeutic use
Brain Abscess/therapy
Chemical and Drug Induced Liver Injury/surgery
Cytomegalovirus Infections/therapy
Invasive Pulmonary Aspergillosis/therapy
Liver Transplantation/adverse effects
Lung Abscess/therapy
Mushroom Poisoning/complications
Neuroaspergillosis/therapy
Neurosurgical Procedures
Opportunistic Infections/therapy
Voriconazole/therapeutic use
[Mh] MeSH terms secundary: Biopsy
Brain Abscess/immunology
Brain Abscess/microbiology
Brain Abscess/virology
Chemical and Drug Induced Liver Injury/diagnosis
Chemical and Drug Induced Liver Injury/etiology
Cytomegalovirus Infections/immunology
Cytomegalovirus Infections/virology
Female
Humans
Immunocompromised Host
Immunosuppressive Agents/adverse effects
Invasive Pulmonary Aspergillosis/immunology
Invasive Pulmonary Aspergillosis/microbiology
Lung Abscess/immunology
Lung Abscess/microbiology
Magnetic Resonance Imaging
Middle Aged
Mushroom Poisoning/diagnosis
Neuroaspergillosis/immunology
Neuroaspergillosis/microbiology
Opportunistic Infections/immunology
Opportunistic Infections/microbiology
Opportunistic Infections/virology
Tomography, X-Ray Computed
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); 0 (Immunosuppressive Agents); JFU09I87TR (Voriconazole)
[Em] Entry month:1708
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:150917
[St] Status:MEDLINE
[do] DOI:10.6002/ect.2014.0233

  4 / 247 MEDLINE  
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[PMID]: 25748533
[Au] Autor:Palmisani E; Barco S; Cangemi G; Moroni C; Dufour C; Castagnola E
[Ad] Address:a Hematology Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
[Ti] Title:Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl.
[So] Source:J Chemother;29(1):42-44, 2017 Feb.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This case report indicates the usefulness of voriconazole for the treatment of central nervous system (CNS) aspergillosis, also in paediatrics. However, it also confirms the need for therapeutic drug monitoring (TDM), especially in younger children that may require very high dosages in order to achieve plasma and cerebrospinal fluid (CSF) therapeutic concentrations.
[Mh] MeSH terms primary: Antifungal Agents/administration & dosage
Neuroaspergillosis/drug therapy
Voriconazole/administration & dosage
[Mh] MeSH terms secundary: Antifungal Agents/cerebrospinal fluid
Antineoplastic Agents/therapeutic use
Female
Humans
Immunocompromised Host
Infant
Neuroaspergillosis/immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Voriconazole/cerebrospinal fluid
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); 0 (Antineoplastic Agents); JFU09I87TR (Voriconazole)
[Em] Entry month:1704
[Cu] Class update date: 170427
[Lr] Last revision date:170427
[Js] Journal subset:IM
[Da] Date of entry for processing:150310
[St] Status:MEDLINE
[do] DOI:10.1179/1973947815Y.0000000009

  5 / 247 MEDLINE  
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[PMID]: 27445566
[Au] Autor:Moreno-González G; Ricart de Mesones A; Tazi-Mezalek R; Marron-Moya MT; Rosell A; Mañez R
[Ad] Address:Intensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, Spain.
[Ti] Title:Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient.
[So] Source:Can Respir J;2016:7984032, 2016.
[Is] ISSN:1916-7245
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection by Aspergillus fumigatus and A. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis.
[Mh] MeSH terms primary: Extracorporeal Membrane Oxygenation
Immunocompetence
Invasive Pulmonary Aspergillosis/diagnosis
Respiratory Insufficiency/therapy
[Mh] MeSH terms secundary: Antifungal Agents/therapeutic use
Aspergillosis/complications
Aspergillosis/pathology
Aspergillus flavus
Aspergillus fumigatus
Autopsy
Bronchoscopy
Fatal Outcome
Female
Humans
Invasive Pulmonary Aspergillosis/complications
Invasive Pulmonary Aspergillosis/drug therapy
Invasive Pulmonary Aspergillosis/pathology
Middle Aged
Myocarditis/complications
Myocarditis/pathology
Nephritis/complications
Nephritis/pathology
Neuroaspergillosis/complications
Neuroaspergillosis/pathology
Radiography, Thoracic
Respiratory Insufficiency/etiology
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1707
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160723
[St] Status:MEDLINE
[do] DOI:10.1155/2016/7984032

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[PMID]: 27097323
[Au] Autor:Marzolf G; Sabou M; Lannes B; Cotton F; Meyronet D; Galanaud D; Cottier JP; Grand S; Desal H; Kreutz J; Schenck M; Meyer N; Schneider F; Dietemann JL; Koob M; Herbrecht R; Kremer S
[Ad] Address:Département de Neuroradiologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
[Ti] Title:Magnetic Resonance Imaging of Cerebral Aspergillosis: Imaging and Pathological Correlations.
[So] Source:PLoS One;11(4):e0152475, 2016.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent. Hematogenous dissemination was observed in 13 patients, all were immunosuppressed. In this later group we identified a total of 329 parenchymal abscesses involving the whole brain with a predilection for the corticomedullary junction. More than half the patients had a corpus callosum lesion. Hemorrhagic lesions accounted for 13% and contrast enhancement was observed in 61% of the lesions. Patients with hematogenous dissemination were younger (p = 0.003), had more intracranial lesions (p = 0.0004) and had a higher 12-week mortality rate (p = 0.046) than patients with direct spread from paranasal sinuses. Analysis of 12 aneurysms allowed us to highlight two distinct situations. In case of direct spread from the paranasal sinuses, aneurysms are saccular and located on the proximal artery portions, while the hematogenous dissemination in immunocompromised patients is more frequently associated with distal and fusiform aneurysms. MRI is the exam of choice for cerebral aspergillosis. Number and type of lesions are different according to the mode of dissemination of the infection.
[Mh] MeSH terms primary: Brain Diseases/diagnosis
Brain Diseases/pathology
Magnetic Resonance Imaging
Neuroaspergillosis/diagnosis
Neuroaspergillosis/pathology
[Mh] MeSH terms secundary: Adult
Aged
Brain Diseases/complications
Brain Diseases/immunology
Humans
Male
Middle Aged
Neuroaspergillosis/complications
Neuroaspergillosis/immunology
Paranasal Sinuses/microbiology
Prognosis
Retrospective Studies
Vascular Diseases/complications
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1608
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:160421
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0152475

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[PMID]: 27050914
[Au] Autor:Bourne EL; Dimou J
[Ad] Address:John Hunter Hospital, Lookout Road, New Lambton Heights, NSW 2305, Australia. Electronic address: emmalee.bourne@hnehealth.nsw.gov.au.
[Ti] Title:Invasive central nervous system aspergillosis in a patient with Crohn's disease after treatment with infliximab and corticosteroids.
[So] Source:J Clin Neurosci;30:163-164, 2016 Aug.
[Is] ISSN:1532-2653
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:Aspergillus species are emerging as a significant cause of pneumonia mortality in immune compromised hosts, with haematological spread being a rare and life-threatening complication. The central nervous system (CNS) as a site for extrapulmonary spread is rarer still. We report a case of CNS disseminated aspergillosis in a patient treated with corticosteroids and infliximab, an immunomodulatory agent commonly used in the treatment of inflammatory bowel disease, and review the available literature regarding this rare pathology.
[Mh] MeSH terms primary: Adrenal Cortex Hormones/adverse effects
Crohn Disease/drug therapy
Infliximab/adverse effects
Neuroaspergillosis/chemically induced
Neuroaspergillosis/diagnostic imaging
[Mh] MeSH terms secundary: Adrenal Cortex Hormones/administration & dosage
Crohn Disease/diagnostic imaging
Drug Therapy, Combination
Female
Humans
Immunosuppressive Agents/administration & dosage
Immunosuppressive Agents/adverse effects
Infliximab/administration & dosage
Middle Aged
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Adrenal Cortex Hormones); 0 (Immunosuppressive Agents); B72HH48FLU (Infliximab)
[Em] Entry month:1703
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160407
[St] Status:MEDLINE

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[PMID]: 26853515
[Au] Autor:Ellenbogen JR; Waqar M; Cooke RP; Javadpour M
[Ad] Address:a Neurosurgery Department , the Walton Centre NHS Foundation Trust , Liverpool , UK ;
[Ti] Title:Management of granulomatous cerebral aspergillosis in immunocompetent adult patients: a review.
[So] Source:Br J Neurosurg;30(3):280-5, 2016 Jun.
[Is] ISSN:1360-046X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Cerebral aspergillosis, is an infrequent, opportunistic infection of the central nervous system that accounts for 5-10% of all intracranial fungal pathology. It is uncommon in immunocompetent patients and has a significant disease burden, with high morbidity and mortality, even with appropriate treatment. Basic principles of abscess management should be employed, including aspiration and targeted anti-fungal therapy for 12-18 months. However, reported outcomes with a purely minimally invasive approach are poor and there should be a low threshold for surgical excision, especially in resource poor settings and in patients with deteriorating neurology harbouring sizeable masses. Evidence favouring gross total excision over subtotal resection is lacking, however. It is notable that these recommendations are largely based on retrospective case series and isolated case reports. There is a need therefore for international collaboration to evaluate management strategies for immunocompetent patients with cerebral aspergillosis.
[Mh] MeSH terms primary: Antifungal Agents/therapeutic use
Aspergillosis/drug therapy
Central Nervous System/surgery
Nervous System Diseases/drug therapy
Nervous System Diseases/surgery
[Mh] MeSH terms secundary: Aspergillosis/immunology
Aspergillosis/surgery
Central Nervous System/pathology
Humans
Nervous System Diseases/immunology
Postoperative Care
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1703
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160209
[St] Status:MEDLINE
[do] DOI:10.3109/02688697.2016.1139046

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[PMID]: 26659218
[Au] Autor:Chong GM; Maertens JA; Lagrou K; Driessen GJ; Cornelissen JJ; Rijnders BJ
[Ad] Address:Erasmus University Medical Center, Department of Internal Medicine, Section of Infectious Diseases, Rotterdam, the Netherlands g.chong@erasmusmc.nl.
[Ti] Title:Diagnostic Performance of Galactomannan Antigen Testing in Cerebrospinal Fluid.
[So] Source:J Clin Microbiol;54(2):428-31, 2016 Feb.
[Is] ISSN:1098-660X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Testing cerebrospinal fluid (CSF) for the presence of galactomannan (GM) antigen may help in diagnosing cerebral aspergillosis (CA). However, the use of the CSF GM test as a diagnostic test has been little studied. We evaluated its diagnostic performance by comparing the CSF GM optical density indexes (ODI) at different cutoffs in patients with probable and proven CA to those in patients without CA. Patients from 2 tertiary referral hospitals with suspected CA between 2004 and 2014 and in whom CSF GM ODI had been determined were selected. European Organization for Research and Treatment of Cancer/Invasive Infectious Diseases Study Mycoses Group (EORTC/MSG) definitions of invasive aspergillosis and CA were used, but with the exclusion of the test to be validated (i.e., the CSF GM test) as a microbiological EORTC/MSG criterion. The study population consisted of 44 patients (4 with proven CA, 13 with probable CA, and 27 with no CA). Of the 17 patients with CA, 15 had a CSF GM ODI of ≥2.0. Of 27 patients without CA, 26 had a CSF GM ODI of <0.5 and 1 had a CSF GM ODI of 8.2. When a GM CSF ODI cutoff of 1.0 was used, the sensitivity, specificity, and positive and negative predictive values were 88.2%, 96.3%, 93.8%, and 92.9%, respectively. The same results were found when a CSF GM ODI cutoff of 0.5 or 2.0 was used. Testing GM in CSF has a high diagnostic performance for diagnosing CA and may be useful to diagnose or virtually rule out the infection without the need for a cerebral biopsy.
[Mh] MeSH terms primary: Antigens, Fungal/cerebrospinal fluid
Antigens, Fungal/immunology
Mannans/cerebrospinal fluid
Mannans/immunology
Neuroaspergillosis/diagnosis
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antigens, Fungal); 0 (Mannans); 11078-30-1 (galactomannan)
[Em] Entry month:1611
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:151215
[St] Status:MEDLINE
[do] DOI:10.1128/JCM.02913-15

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[PMID]: 26315007
[Au] Autor:Neil JA; Orlandi RR; Couldwell WT
[Ad] Address:Department of Neurosurgery; and.
[Ti] Title:Malignant fungal infection of the cavernous sinus: case report.
[So] Source:J Neurosurg;124(3):861-5, 2016 Mar.
[Is] ISSN:1933-0693
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Intracranial spread of fungal infection is a life-threatening condition that usually affects immunocompromised patients. Here the authors present a case of biopsy-proven Aspergillus fumigatus infection of the paranasal sinuses in an immunocompetent patient with documented spread to the orbit, cavernous sinus, and petrous apex despite medical antifungal treatment. As a life-saving treatment, cavernous sinus resection with external carotid artery-middle cerebral artery bypass was performed. The authors discuss the literature regarding the intracranial spread of paranasal sinus fungal infections in immunocompetent patients and management strategies.
[Mh] MeSH terms primary: Aspergillus fumigatus
Cavernous Sinus
Neuroaspergillosis/diagnosis
[Mh] MeSH terms secundary: Aged
Antifungal Agents/therapeutic use
Humans
Male
Neuroaspergillosis/etiology
Neuroaspergillosis/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1607
[Cu] Class update date: 160301
[Lr] Last revision date:160301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150829
[St] Status:MEDLINE
[do] DOI:10.3171/2015.2.JNS142668


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