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[PMID]: 29203736
[Au] Autor:Lutsenko RV; Vlasova EV; Kolot EG; Gladka VM; Sidorenko AG
[Ad] Address:Higher State Educational Establishment Of Ukraine, "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
[Ti] Title:The exchange of monoamines during the experimental neurosis on the background of using of amide "2-hydroxy-n-naphthalen-1-yl-2-(2-oxo-,2-dihydroindol-3-ylidene)".
[So] Source:Wiad Lek;70(5):895-900, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Incessant increase in the frequency and distribution of anxiety disorders stipulates searching, research and study of the mechanism of action of new substances for their correction, including the group of 2-oxoindolin-3-glyoxylic acid derivatives. THE AIM: To research the effect of N-(1-naphthyl) amide-2-oxoindolin-3-glyoxylic acid on monoaminergic system of subjected to experimental neurosis of rats. MATERIALS AND METHODS: The experiments were performed on male Wistar rats, who have weight 180-220g and were researching the effect of 2-hydro-N-naphthalen-1-yl-2-(2-oxy-1,2-dihydroindol-3-ylidene)-acetamide (compound 18) at a dose (12 mg/kg), by intragastric drug injection of subjected to experimental neurosis rats, during 30 days (1 time in three days), for monoamines content (epinephrine, norepinephrine, dopamine and serotonin) in the blood, their decay products (homovanillic acid, vanillylmandelic acid and 5-oxyindolacetic acid) in the urine and the ratio of end products of the reaction to their predecessors. RESEARCH: It was established that during the preventive-therapeutic application of N-(1-naphthyl)amide-2-oxoindolin-3-glyoxylic acid, it effectively adjusts the level of monoamines, reducing the content of adrenaline and increasing the content of noradrenaline, dopamine and 5-HT in the blood. The compound also reduces the content of products exchange of mediators (HVA,VMA and 5-OIAA) in the urine. The 2-oxoindolin derivatives reduces the ratio between HVA/dopamine, VMA/(noradrenaline + adrenaline) and 5-OIAA/5-HT, it testifies about the normalizing of enzymes activity, which are involved in the process of exchange and maintaining the constancy of monoamines. The results show that in the mechanisms of anxiolytic action of compound 18, a significant role plays the normalization of content and exchange of neurotransmitters in the organism, which caused an experimental neurosis. CONCLUSION: Compound 2-hydro-N-naphthalen-1-yl-2-(2-oxo-1,2-dihydroindol-3-ylidene)-acetamide by the experimental 30-day neurosis, was reducing the expression of neurotransmitter imbalance in the blood, apparently due to correction of enzymatic synthesis links and biotransformation of monoamines.
[Mh] MeSH terms primary: Adamantane/analogs & derivatives
Anti-Anxiety Agents/pharmacology
Anxiety Disorders/drug therapy
Benzimidazoles/pharmacology
Depressive Disorder/drug therapy
Morpholines/pharmacology
[Mh] MeSH terms secundary: Adamantane/pharmacology
Animals
Biogenic Monoamines/pharmacology
Humans
Male
Rats
Rats, Wistar
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole); 0 (Anti-Anxiety Agents); 0 (Benzimidazoles); 0 (Biogenic Monoamines); 0 (Morpholines); 0 (N-(2-adamantyl)-N-p-bromophenylamine); PJY633525U (Adamantane)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE

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[PMID]: 27771133
[Au] Autor:Ehrenreich-May J; Rosenfield D; Queen AH; Kennedy SM; Remmes CS; Barlow DH
[Ad] Address:University of Miami, Department of Psychology, 5665 Ponce de Leon Blvd, Flipse Building, Room 315, Coral Gables, FL 33146, United States. Electronic address: j.ehrenreich@miami.edu.
[Ti] Title:An initial waitlist-controlled trial of the unified protocol for the treatment of emotional disorders in adolescents.
[So] Source:J Anxiety Disord;46:46-55, 2017 Mar.
[Is] ISSN:1873-7897
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:A substantial proportion of adolescents are non-responders to well-established treatments for anxiety and depression, and many existent approaches do not adequately address comorbidity. There is a need to develop and evaluate unified treatments for adolescents that flexibly address higher order factors shared among internalizing or emotional disorders. The Unified Protocol for the Treatment of Emotional Disorders in Adolescents (UP-A) is a transdiagnostic treatment that targets shared vulnerability and maintenance factors in a flexible format. This study examined initial outcomes of a randomized, waitlist-controlled trial of the UP-A. The UP-A outperformed waitlist at mid-treatment with respect to disorder severity and functional impairment, and there was a significant treatment effect in favor of the UP-A on all outcome measures at post-treatment. Within-subjects analyses collapsing across participants revealed significant improvements on outcome measures over time. Results support further study of the UP-A and its potential efficacy in treating adolescent anxiety and depression.
[Mh] MeSH terms primary: Anxiety Disorders/therapy
Cognitive Therapy/methods
Depressive Disorder/therapy
[Mh] MeSH terms secundary: Adolescent
Anxiety/psychology
Anxiety/therapy
Anxiety Disorders/psychology
Child
Depression/psychology
Depression/therapy
Depressive Disorder/psychology
Female
Humans
Male
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1709
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE

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[PMID]: 29514629
[Au] Autor:Moschetti K; Zabrodina V; Wangmo T; Holly A; Wasserfallen JB; Elger BS; Gravier B
[Ad] Address:Institute of Social and Preventive Medicine, University of Lausanne and University Hospital of Lausanne (CHUV), Route de la Corniche 10, 1010, Lausanne, Switzerland. karine.moschetti@chuv.ch.
[Ti] Title:The determinants of individual health care expenditures in prison: evidence from Switzerland.
[So] Source:BMC Health Serv Res;18(1):160, 2018 Mar 07.
[Is] ISSN:1472-6963
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Prison health systems are subject to increasing pressures given the specific health needs of a growing and aging prison population. Identifying the drivers of medical spending among incarcerated individuals is therefore key for health care governance in prisons. This study assesses the determinants of individual health care expenditures within the prisons of the canton of Vaud, a large region of Switzerland. METHODS: We use a unique dataset linking demographic and prison stay characteristics as well as objective measures of morbidity to detailed medical invoice data. We adopt a multivariate regression approach to model total, somatic and psychiatric outpatient health care expenditures. RESULTS: We find that chronic infectious, musculoskeletal and skin diseases are strong predictors of total and somatic costs. Schizophrenia, neurotic and personality disorders as well as the abuse of illicit drugs and pharmaceuticals drive total and psychiatric costs. Furthermore, cumulating psychiatric and somatic comorbidities has an incremental effect on costs. CONCLUSION: By identifying the characteristics associated with health care expenditures in prison, this study constitutes a key step towards a more efficient use of medical resources in prison.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1186/s12913-018-2962-8

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[PMID]: 29406643
[Au] Autor:Ivey J
[Ti] Title:Natural Disasters: Looking at the Consequences.
[So] Source:Pediatr Nurs;42(5):242, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Anxiety Disorders/diagnosis
Anxiety Disorders/psychology
Cyclonic Storms
Disasters
Stress Disorders, Post-Traumatic/diagnosis
Stress Disorders, Post-Traumatic/psychology
Survivors/psychology
[Mh] MeSH terms secundary: Adolescent
Age Factors
Child
Child, Preschool
Cross-Sectional Studies
Female
Humans
Male
New Jersey
Sex Factors
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:N
[Da] Date of entry for processing:180207
[St] Status:MEDLINE

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[PMID]: 29406642
[Au] Autor:Quinn M; Gillooly D; Kelly S; Kolassa J; Davis E; Jankowski S
[Ti] Title:Evaluation of Identified Stressors in Children and Adolescents After Super Storm Sandy.
[So] Source:Pediatr Nurs;42(5):235-41, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Super Storm Sandy, one of the largest storms endured by the East Coast of theUnited States, devastated New Jersey and the eastern seaboard. Although naturaldisasters affect individuals of all ages, children are particularly vulnerable becausetheir sense of normalcy is altered. The purpose of this study was to explore theeffects that exposure to Super Storm Sandy had on children who resided in NewJersey. This was a non-experimental, quantitative, cross-sectional research study.Study participants were recruited via printed flyers at disaster resource sites and ona dedicated research team's Facebook site. Each participant completed theHurricane Stressors Assessment Tool for Children and Adolescents as a webbasedsurvey related to their experiences with the hurricane. One hundred andforty-one (141) children participated in this study. Age groups (preschool, child, andadolescent) had varied results based upon developmental level. Age was positivelyassociated with finding it harder to concentrate and pay attention (r = 0.18, p =0.04); feeling sad, down, or depressed (r = 0.17, p < 0.05); being quiet and withdrawn (r = 0.16, p = 0.05); feeling irritable and grouchy (r = 0.26, p < 0.05); and findingit harder to complete schoolwork (r = 0.32, p < 0.001). Certain parental perceptionsof their child's behavior were negatively associated with the age of the child.Children had varying degrees of experiences after Sandy. Adolescents were shownto be more aware and affected by the storm than younger children. Observationscan be used for intervention initiatives in the post-natural disaster period, encouraginghealthcare providers to acknowledge family and community healing to provideadequate mental health referrals in the post-disaster period.
[Mh] MeSH terms primary: Anxiety Disorders/diagnosis
Anxiety Disorders/psychology
Cyclonic Storms
Disasters
Stress Disorders, Post-Traumatic/diagnosis
Stress Disorders, Post-Traumatic/psychology
Survivors/psychology
[Mh] MeSH terms secundary: Adolescent
Age Factors
Child
Child, Preschool
Cross-Sectional Studies
Female
Humans
Male
New Jersey
Sex Factors
Surveys and Questionnaires
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:N
[Da] Date of entry for processing:180207
[St] Status:MEDLINE

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[PMID]: 28448826
[Au] Autor:Goodwin H; Yiend J; Hirsch CR
[Ad] Address:Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London, United Kingdom.
[Ti] Title:Generalized Anxiety Disorder, worry and attention to threat: A systematic review.
[So] Source:Clin Psychol Rev;54:107-122, 2017 Jun.
[Is] ISSN:1873-7811
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Among anxious populations, attention has been demonstrated to be preferentially biased to threatening material compared to neutral or other valenced material. Individuals who have high levels of trait worry, such as those with Generalized Anxiety Disorder (GAD), may be biased to threat but research has produced equivocal findings. This review aimed to systematically review the extant experimental literature to establish the current evidence of attentional bias to threat among trait worriers compared to healthy controls and other clinical populations. Twenty-nine published articles were included in the final review. There was strong evidence of a bias to threat among GAD patients compared to other groups and this was found across most experimental paradigms. Few studies had investigated this bias in non-clinical trait worriers. Among GAD patients this bias to threat was most strongly evidenced when visual threat material was in a verbal-linguistic format (i.e., words) rather than when in pictorial form (i.e., images or faces). The bias was also found across several domains of negative material, supporting the general nature of worry. Further research should look to examine the specific components of the threat bias in GAD, as well as investigating the bias to threat in trait worriers.
[Mh] MeSH terms primary: Anxiety Disorders/psychology
Anxiety/psychology
Attention/physiology
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170428
[St] Status:MEDLINE

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[PMID]: 29450528
[Au] Autor:Gupta R
[Ad] Address:University of Michigan Medical School, Ann Arbor.
[Ti] Title:I Solemnly Share.
[So] Source:JAMA;319(6):549-550, 2018 Feb 13.
[Is] ISSN:1538-3598
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Depressive Disorder
Students, Medical/psychology
[Mh] MeSH terms secundary: Adaptation, Psychological
Depressive Disorder/psychology
Depressive Disorder/therapy
Education, Medical, Undergraduate
Female
Humans
[Pt] Publication type:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180217
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.22135

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[PMID]: 29181908
[Ti] Title:Spiseforstyrrelsen som åpnet for bruk av anabole steroider. The eating disorder that paved the way for anabolic steroid use.
[So] Source:Tidsskr Nor Laegeforen;137(22), 2017 11 28.
[Is] ISSN:0807-7096
[Cp] Country of publication:Norway
[La] Language:eng; nor
[Mh] MeSH terms primary: Anabolic Agents/adverse effects
Anorexia Nervosa/psychology
Testosterone Congeners/adverse effects
[Mh] MeSH terms secundary: Anabolic Agents/administration & dosage
Body Image
Depressive Disorder/therapy
Humans
Quality of Health Care
Self-Control/psychology
Testosterone Congeners/administration & dosage
[Pt] Publication type:PERSONAL NARRATIVES
[Nm] Name of substance:0 (Anabolic Agents); 0 (Testosterone Congeners)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:171129
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0168

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[PMID]: 28458487
[Au] Autor:Mukeshimana M; Mchunu G
[Ad] Address:College of Medicine and Health Sciences, University of Rwanda, Rwanda.
[Ti] Title:Management of Co-Morbidity of Depression and Chronic Non-Communicable Diseases in Rwanda.
[So] Source:Ethiop J Health Sci;27(1):17-26, 2017 Jan.
[Is] ISSN:2413-7170
[Cp] Country of publication:Ethiopia
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chronic non-communicable diseases (NCDs) are a major global health problem of the 21 stcentury. They are now the world's leading cause of disease burden and high mortality. An even more alarming health problem is when depression coexists with chronic NCDs, as is frequently the case. Management of this co-morbidity with collaborative care has become a global topic of interest, with the World Health Organization (WHO) recommending implementation of collaborative care for this purpose. The study investigated existing protocols and/or interventions for managing this co-morbidity in Rwandan district hospitals. METHODS: The study used an action research design involving a research team of 14 health care professionals to collaboratively identify existing protocols or interventions for managing co-morbidity of depression and NCDs in Rwanda. Focus group discussion using a structured interview guide was used to collect qualitative data, followed by qualitative content analysis using inductive approach. RESULTS: We found no particular protocols or interventions in place to manage the co-morbidity of depression and chronic NCDs. Depression and chronic NCDs were found to be treated separately, in separate health care settings and by different health professionals. CONCLUSION: The findings revealed a gap in management of co-morbid depression and chronic NCDs in Rwanda district hospitals. We recommend that health care providers follow the WHO collaborative care advisory for better quality care and better patient improvement in management of this co-morbidity.
[Mh] MeSH terms primary: Depressive Disorder/epidemiology
Depressive Disorder/therapy
Noncommunicable Diseases/epidemiology
Noncommunicable Diseases/therapy
[Mh] MeSH terms secundary: Chronic Disease
Comorbidity
Humans
Rwanda/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:170502
[St] Status:MEDLINE

  10 / 95470 MEDLINE  
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[PMID]: 29488029
[Au] Autor:Norredam M; Nellums L; Nielsen RS; Byberg S; Petersen JH
[Ad] Address:Danish Research Centre for Migration, Ethnicity, and Health (MESU), University of Copenhagen, Øster Farimagsgade 5, PO Box 2099, 1014, Copenhagen K, Denmark. mano@sund.ku.dk.
[Ti] Title:Incidence of psychiatric disorders among accompanied and unaccompanied asylum-seeking children in Denmark: a nation-wide register-based cohort study.
[So] Source:Eur Child Adolesc Psychiatry;, 2018 Feb 27.
[Is] ISSN:1435-165X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:One in four asylum applicants in Europe are children, and 23% of whom are unaccompanied and may be at increased risk of mental illness. This study contributes to the limited evidence base by comparing the incidence of psychiatric disorders among unaccompanied and accompanied refugee children. We linked a cohort of refugee children who obtained right of residency in Denmark between 01 January 1993 and 31 December 2010 to the Danish Psychiatric Central Register, and calculated incidence rates per 100,000 person years and incidence rate ratios of overall psychiatric disorder, psychotic disorders, affective disorders, and neurotic disorders for accompanied and unaccompanied minors using Poisson regression. We adjusted the analyses for sex, age at residency, and age at arrival (aIRR). Stratified analyses were conducted by nationality. Unaccompanied minors had significantly higher rates of any psychiatric disorder (aIRR: 1.38, 95% CI 1.14-1.68) and neurotic disorders (aIRR: 1.67, 95% CI 1.32-2.13) than accompanied minors. Among children from Afghanistan, unaccompanied minors had significantly higher rates of any psychiatric disorder (aIRR: 2.23, 95% CI 1.26-3.93) and neurotic disorders (aIRR: 3.50, 95% CI 1.72-7.11). Among children from Iraq, unaccompanied minors had higher rates of any psychiatric disorder (aIRR: 2.02, 95% CI 1.18-3.45), affective disorders (aIRR: 6.04, 95% CI 2.17-16.8), and neurotic disorders (aIRR: 3.04, 95% CI 1.62-5.70). Unaccompanied children were found to experience a higher incidence of any psychiatric disorder and neurotic disorders. Strategies are needed to address the specific mental health and social needs of unaccompanied minors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:Publisher
[do] DOI:10.1007/s00787-018-1122-3


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