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[PMID]: 29314204
[Au] Autor:Jin Z; Tan Q; Sun B
[Ad] Address:State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing, China.
[Ti] Title:Telmisartan ameliorates vascular endothelial dysfunction in coronary slow flow phenomenon (CSFP).
[So] Source:Cell Biochem Funct;36(1):18-26, 2018 Jan.
[Is] ISSN:1099-0844
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Coronary slow flow phenomenon (CSFP) is a coronary microvascular disorder with an increasing morbidity, and currently, available therapies are of limited clinical value for its cure. Hence, it is urgent to find a novel approach to CSFP treatment. Several studies show that endothelial dysfunction plays a critical role in the aetiology of CSFP. Telmisartan (TMST) is a clinically available anti-hypertensive medicine and has shown its potential properties for improving vascular endothelial function. Thus, we aimed to investigate the effect of TMST on endothelial dysfunction in CSFP, Endothelial-dependent flow-mediated vasodilation, serum levels of nitric oxide, adiponectin, and endothelin-1 were surveyed before and after 3 months of TMST treatment. And the percentages of vasodilator response to acetylcholine (Ach) were detected after 12 weeks of TMST treatment. Compare with pretreatment, flow-mediated vasodilation, nitric oxide, and adiponectin were substantially improved after TMST treatment; meanwhile, endothelin-1 was decreased in the TMST group (all P < .01). Compared with the model group, the vasodilator response to Ach was enormously increased after TMST intervention. Additionally, administration of SU11274 or GW9662 would partially reverse the protective effects of TMST on accumulative concentration-vasodilator responses to Ach (P < .01). We demonstrated that administration of TMST could remarkably increase the mRNA and/or protein levels of hepatocyte growth factor, mesenchymal-epithelial transition factor, peroxisome proliferation-activated receptor γ, whereas dramatically diminish mRNA and/or protein levels of p-JNK1/2, mitogen-activated protein kinase, and nuclear factor kappa B (P < .05). Our results thus implicate that TMST ameliorates endothelial dysfunction in CSFP. It is suggested that TSMF may play an important role in the medication of CSFP.
[Mh] MeSH terms primary: Benzimidazoles/pharmacology
Benzimidazoles/therapeutic use
Benzoates/pharmacology
Benzoates/therapeutic use
Endothelium, Vascular/drug effects
Endothelium, Vascular/physiopathology
No-Reflow Phenomenon/drug therapy
[Mh] MeSH terms secundary: Angiotensin II/pharmacology
Animals
Benzimidazoles/chemistry
Benzoates/chemistry
Dose-Response Relationship, Drug
Endothelium, Vascular/metabolism
Female
Humans
Male
Middle Aged
Rabbits
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Benzimidazoles); 0 (Benzoates); 11128-99-7 (Angiotensin II); U5SYW473RQ (telmisartan)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1002/cbf.3313

  2 / 1092 MEDLINE  
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[PMID]: 29390391
[Au] Autor:Negishi Y; Ishii H; Suzuki S; Aoki T; Iwakawa N; Kojima H; Harada K; Hirayama K; Mitsuda T; Sumi T; Tanaka A; Ogawa Y; Kawaguchi K; Murohara T
[Ad] Address:Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Title:The combination assessment of lipid pool and thrombus by optical coherence tomography can predict the filter no-reflow in primary PCI for ST elevated myocardial infarction.
[So] Source:Medicine (Baltimore);96(50):e9297, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The usefulness of distal protection devices is still controversial. Moreover, there is no report on thrombus evaluation by using optical coherence tomography (OCT) for determining whether to use a distal protection device. The aim of the present study was to investigate the predictor of filter no-reflow (FNR) by using OCT in primary percutaneous coronary intervention (PCI) for ST-elevated acute myocardial infarction (STEMI).We performed preinterventional OCT in 25 patients with STEMI who were undergoing primary PCI with Filtrap. FNR was defined as coronary flow decreasing to TIMI flow grade 0 after mechanical dilatation.FNR was observed in 13 cases (52%). In the comparisons between cases with or without the FNR, the stent length, lipid pool length, lipid pool + thrombus length, and lipid pool + thrombus index showed significant differences. In multivariate analysis, lipid pool + thrombus length was the only independent predictor of FNR (OR 1.438, 95% CI 1.001 - 2.064, P < .05). The optimal cut-off value of lipid pool + thrombus length for predicting FNR was 13.1 mm (AUC = 0.840, sensitivity 76.9%, specificity 75.0%). Moreover, when adding the evaluation of thrombus length to that of lipid pool length, the prediction accuracy of FNR further increased (IDI 0.14: 0.019-0.25, P = .023).The longitudinal length of the lipid pool plus thrombus was an independent predictor of FNR and the prediction accuracy improved by adding the thrombus to the lipid pool. These results might be useful for making intraoperative judgment about whether filter devices should be applied in primary PCI for STEMI.
[Mh] MeSH terms primary: Coronary Thrombosis/diagnostic imaging
Lipids/analysis
Percutaneous Coronary Intervention
ST Elevation Myocardial Infarction/diagnostic imaging
ST Elevation Myocardial Infarction/surgery
Tomography, Optical Coherence
[Mh] MeSH terms secundary: Coronary Angiography
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Myocardial Reperfusion
No-Reflow Phenomenon/diagnostic imaging
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Lipids)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009297

  3 / 1092 MEDLINE  
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[PMID]: 29371134
[Au] Autor:Costa MA; Paiva AE; Andreotti JP; Cardoso MV; Cardoso CD; Mintz A; Birbrair A
[Ad] Address:Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
[Ti] Title:Pericytes constrict blood vessels after myocardial ischemia.
[So] Source:J Mol Cell Cardiol;116:1-4, 2018 Feb 02.
[Is] ISSN:1095-8584
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) by using state-of-the-art technologies, including high-resolution confocal imaging in combination with myocardial ischemia/reperfusion mouse model, reveal that pericytes contribute to the no-reflow phenomenon post-ischemia in the heart. Strikingly, intravenous adenosine increased vascular diameter at pericyte site after cardiac ischemia. This study provides a novel therapeutic target to inhibit no-reflow phenomenon after myocardial ischemia.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher

  4 / 1092 MEDLINE  
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[PMID]: 29332028
[Au] Autor:Yu SJ; Buerck JP; O'Rear EA; Whitsett TL
[Ad] Address:Department of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK 73019, USA.
[Ti] Title:Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon.
[So] Source:Biorheology;54(2-4):81-93, 2018.
[Is] ISSN:1878-5034
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE: To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon. METHODS: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour. Red cell deformability was tested by both a microscopic photometric and a filtration technique, viscosity by a cone and plate viscometer, and erythrocyte aggregation by an optical aggregometer. RESULTS: Two sampling methods were devised for the microscopic photometric test, both of which indicated increases of erythrocyte stiffness after being lysed from the clot by SK. In accompanying experiments, the viscosity, aggregation and filterability of the post-lytic erythrocytes were assessed. Results indicated increased viscosity in Ringer's, decreased aggregation index and filterability through a 5 µm pore size Nuclepore membrane. CONCLUSION: Findings demonstrated that post-lytic changes in red cell deformability do occur which could contribute to the no-reflow phenomenon.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Data-Review
[do] DOI:10.3233/BIR-17144

  5 / 1092 MEDLINE  
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[PMID]: 29320987
[Au] Autor:Niu X; Zhang J; Bai M; Peng Y; Sun S; Zhang Z
[Ad] Address:The First School of Clinical Medicine, Lanzhou University, Tianshui South Road, No. 222, Lanzhou, Gansu, 730000, China.
[Ti] Title:Effect of intracoronary agents on the no-reflow phenomenon during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: a network meta-analysis.
[So] Source:BMC Cardiovasc Disord;18(1):3, 2018 01 10.
[Is] ISSN:1471-2261
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Despite the restoration of epicardial flow after primary percutaneous coronary intervention (PPCI), myocardial reperfusion remains impaired in a significant proportion of patients. We performed a network meta-analysis to assess the effect of 7 intracoronary agents (adenosine, anisodamine, diltiazem, nicorandil, nitroprusside, urapidil, and verapamil) on the no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) undergoing PPCI. METHODS: Database searches were conducted to identify randomized controlled trials (RCTs) comparing the 7 agents with each other or with standard PPCI. Outcome measures included thrombolysis in myocardial infarction flow grade (TFG), ST-segment resolution (STR), left ventricular ejection fraction (LVEF), major adverse cardiovascular events (MACEs), and adverse events. RESULTS: Forty-one RCTs involving 4069 patients were analyzed. The addition of anisodamine to standard PPCI for STEMI was associated with improved post-procedural TFG, more occurrences of STR, and improvement of LVEF. The cardioprotective effect of anisodamine conferred a MACE-free survival benefit. Additionally, nitroprusside was regarded as efficient in improving coronary flow and clinical outcomes. Compared with standard care, adenosine, nicorandil, and verapamil improved coronary flow but had no corresponding benefits regarding cardiac function and clinical outcomes. The ranking probability for the 7 treatment drugs showed that anisodamine consistently ranked the highest in efficacy outcomes (TFG < 3, STR, LVEF, and MACEs). No severe adverse events, such as hypotension and malignant arrhythmia, were observed in patients treated with anisodamine. Network meta-regression analysis showed that age, the time to reperfusion, and study follow-up did not affect the treatment effects. CONCLUSIONS: The intracoronary administration of anisodamine appears to improve myocardial reperfusion, cardiac function, and clinical outcomes in patients with STEMI undergoing PPCI. Given the limited quality and quantity of the included studies, more rigorous RCTs are needed to verify the role of this inexpensive and well-tolerated regimen.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process
[do] DOI:10.1186/s12872-017-0722-z

  6 / 1092 MEDLINE  
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[PMID]: 28456697
[Au] Autor:Satogami K; Ino Y; Kubo T; Tanimoto T; Orii M; Matsuo Y; Ota S; Yamaguchi T; Shiono Y; Shimamura K; Katayama Y; Aoki H; Nishiguchi T; Ozaki Y; Yamano T; Kameyama T; Kuroi A; Kitabata H; Tanaka A; Hozumi T; Akasaka T
[Ad] Address:Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
[Ti] Title:Impact of Plaque Rupture Detected by Optical Coherence Tomography on Transmural Extent of Infarction After Successful Stenting in ST-Segment Elevation Acute Myocardial Infarction.
[So] Source:JACC Cardiovasc Interv;10(10):1025-1033, 2017 May 22.
[Is] ISSN:1876-7605
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of the present study was to investigate the association between plaque rupture (PR) assessed by optical coherence tomography (OCT), and the transmural extent of infarction (TEI) assessed by contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). BACKGROUND: PR is associated with larger infarct size as assessed by cardiac enzymes in STEMI patients. CE-CMR is a favorable method to assess TEI, which can predict the prognosis of STEMI patients. METHODS: First, STEMI patients with primary PCI within 12 h after onset were enrolled and divided into 2 groups according to presence (n = 71) or absence (n = 32) of PR at the culprit lesion as assessed by pre-intervention OCT. CE-CMR was performed at 1 week after primary PCI. RESULTS: The frequency of no-reflow phenomenon (37% vs. 16%; p = 0.032) and distal embolization (24% vs. 6%; p = 0.032) was significantly higher in the rupture group compared with the non-rupture group. TEI grade was significantly greater in the rupture group (28% vs. 15% in grade 3 and 45% vs. 13% in grade 4; p < 0.001). Microvascular obstruction was more frequently seen in the rupture group (39% vs. 19%; p = 0.039). Multivariate analysis identified PR (odds ratio: 6.60, 95% confidence interval: 2.19 to 21.69; p < 0.001) and no statin use before admission (odds ratio: 3.37, 95% confidence interval: 1.06 to 11.19; p = 0.039) as independent predictors of TEI grade 3 or 4. CONCLUSIONS: PR as assessed by OCT is associated with greater TEI as assessed by CE-CMR in STEMI patients after primary PCI.
[Mh] MeSH terms primary: Coronary Artery Disease/therapy
Coronary Vessels/diagnostic imaging
Magnetic Resonance Imaging
Myocardium/pathology
Percutaneous Coronary Intervention/instrumentation
Plaque, Atherosclerotic
ST Elevation Myocardial Infarction/therapy
Stents
Tomography, Optical Coherence
[Mh] MeSH terms secundary: Aged
Chi-Square Distribution
Contrast Media/administration & dosage
Coronary Angiography
Coronary Artery Disease/diagnostic imaging
Electrocardiography
Embolism/diagnostic imaging
Embolism/etiology
Female
Gadolinium DTPA/administration & dosage
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
No-Reflow Phenomenon/diagnostic imaging
No-Reflow Phenomenon/etiology
Odds Ratio
Percutaneous Coronary Intervention/adverse effects
Predictive Value of Tests
Retrospective Studies
Risk Factors
Rupture, Spontaneous
ST Elevation Myocardial Infarction/diagnostic imaging
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[Js] Journal subset:IM
[Da] Date of entry for processing:170501
[St] Status:MEDLINE

  7 / 1092 MEDLINE  
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[PMID]: 29298651
[Au] Autor:Manolis AS
[Ad] Address:Third Department of Cardiology, Athens University School of Medicine, Sotiria Hospital, Athens. Greece.
[Ti] Title:Is Atherothromboaspiration a Possible Solution for the Prevention of No-Reflow Phenomenon in Acute Coronary Syndromes? Single Centre Experience and Review of the Literature.
[So] Source:Curr Vasc Pharmacol;, 2018 Jan 01.
[Is] ISSN:1875-6212
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Intracoronary thrombus in acute myocardial infarction (MI) confers higher rates of no-reflow with attendant adverse consequences. Earlier randomized-controlled-trials (RCTs) of routine thromboaspiration during percutaneous coronary intervention (PCI) indicated a clinical benefit, but more recent RCTs were negative. However, data of selective use of this adjunctive approach remain scarce. OBJECTIVE: The aim of this single-centre prospective study was to report the results of selective thromboaspiration during PCI in patients with intracoronary thrombi, and also to provide an extensive literature review on current status of thromboaspiration. METHODS: The study included 90 patients (77 men; aged 59.3±12.7 years) presenting with acute MI (ST-elevation MI (STEMI) in 74, non-STEMI in 16) who had intracoronary thrombi and were submitted to thromboaspiration. RESULTS: Total (n=67) or subtotal (n=18) vessel occlusions were present in 85 (94%) patients. Thromboaspiration and subsequent PCI were successful in 89/90 (98.9%) patients, with coronary stenting in 86 (96.6%). In 4 patients with residual thrombus, a mesh-covered stent was implanted. IIb/IIIa-inhibitors were administered in 57 (63.3%) patients. No-reflow occurred in only 1 (1.1%) patient. The post-procedural course was uneventful. Review of the literature revealed several early observational and RCTs and meta-analyses favouring manual, not mechanical, thrombectomy. However, newer RCTs and meta-analyses significantly curtailed the initial enthusiasm for the clinical benefits of routine use of thromboaspiration. CONCLUSION: Selective thromboaspiration for angiographically visible thrombi in MI patients undergoing PCI, as an adjunct to mechanical reperfusion and to IIb/IIIa-inhibitors, may be an option since this manoeuvre may improve procedural and clinical outcome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[St] Status:Publisher
[do] DOI:10.2174/1570161116666180101150956

  8 / 1092 MEDLINE  
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[PMID]: 29280545
[Au] Autor:Patel T; Shah S; Gulati R; Kwan T; Cohen MG; Pancholy S
[Ad] Address:Apex Heart Institute, Ahmedabad, India.
[Ti] Title:Perforated balloon technique: A simple and handy technique to combat no-reflow phenomenon in coronary system.
[So] Source:Catheter Cardiovasc Interv;, 2017 Dec 27.
[Is] ISSN:1522-726X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Examining the efficacy and outcomes of intracoronary (IC) instillation of adenosine using a novel perforated balloon technique (PBT) to combat no-reflow phenomenon during percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). BACKGROUND: Occurrence of no-reflow during PCI is a serious adverse prognostic event and inability to re-establish better flow is associated with poor outcomes. Several pharmacological and non-pharmacological interventions have been used to treat this situation. This series describes the use of PBT for IC adenosine administration and its effects on outcomes during real world interventional practice. METHODS: Subjects comprised of 24 patients with ACS (out of a total of 1,634 patients undergoing PCI between January 2016 and June 2017) in whom we used PBT for IC administration of adenosine to treat coronary no-reflow. RESULTS: PBT for IC adenosine instillation was used in 24 (1.5%) of 1,634 patients undergoing PCI. TIMI grade III flow was established in 21 patients (87.5%). In two patients (8.3%) TIMI grade II flow was established and in one patient (4.2%) we were unsuccessful. CONCLUSION: We demonstrate the safety and efficacy of a novel strategy for adenosine instillation in the distal coronary bed, the PBT. This technique enables rapid and cost-effective treatment of no-reflow phenomenon during PCI for ACS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:Publisher
[do] DOI:10.1002/ccd.27477

  9 / 1092 MEDLINE  
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[PMID]: 29276911
[Au] Autor:Kuznetsov VA; Bessonov IS; Zyrianov IP; Zyrianova TI; Sapozhnikov SS; Potolinskaya YV
[Ad] Address:"Tyumen Cardiology Science Center", Branch of the Federal State Budgetary Science Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences".
[Ti] Title:[Comparison of Direct Stenting Versus Stending After Pre-Dilation in ST-Elevation Myocardial Infarction].
[So] Source:Kardiologiia;57(11):5-10, 2017 Nov.
[Is] ISSN:0022-9040
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:AIM: To study was to assess in-hospital outcomes of direct coronary stenting (DS) compared with stenting after predilation (PD) in patients with ST-elevation myocardial infarction (STEMI). MATERIAL AND METHODS: Data were collected from all patients (n=1103) with STEMI subjected to primary PCI in Tyumen cardiology center from 2006 to 2014. The clinical and angiographic characteristics, in-hospital outcomes, as well as predictors of no-reflow phenomenon were analyzed. The composite of in-hospital death, myocardial infarction (MI) and stent thrombosis were defined as major adverse cardiac events (MACE). RESULTS: Altogether 563 patients (51 %) underwent DS, and in 540 (49 %) stents were implanted after PD. Patients in DS group compared with those in PD group were younger (57.9±10.9 vs 60±11.5 years; p=0.001), less often had chronic kidney disease (5.2 vs 8.4 %; Ñ€=0.034), more often recieved prehospital thrombolysis (25 vs 11.9 %; p.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171225
[Lr] Last revision date:171225
[St] Status:In-Data-Review

  10 / 1092 MEDLINE  
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[PMID]: 29246934
[Au] Autor:O'Sullivan CJ; Groza D; Eberli FR
[Ad] Address:Department of Cardiology, Stadtspital Triemli, Zurich, Switzerland.
[Ti] Title:Left ventricular pseudoaneurysm formation in a patient presenting with a subacute myocardial infarction.
[So] Source:BMJ Case Rep;2017, 2017 Dec 14.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Left ventricular pseudoaneurysm is a rare mechanical complication of acute myocardial infarction. In the present case, an 80-year-old man presenting with a subacute non-ST segment elevation myocardial infarction was found to have an occluded second obtuse marginal branch of the left circumflex coronary artery. Following the implantation of two drug-eluting stents, the patient developed no-reflow phenomenon. Coronary angiography 6 weeks later revealed persistence of the no-reflow phenomenon. During the left ventriculogram, a massive pseudoaneurysm was diagnosed and the patient successfully underwent emergency surgery. The persistence of no-reflow was likely due to the fact that the myocardial territory supplied by the infarct-related artery was completely necrosed resulting in persistent flow impairment through the vessel.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171216
[Lr] Last revision date:171216
[St] Status:In-Process


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