Database : MEDLINE
Search on : Nose and Diseases [Words]
References found : 16276 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 1628 go to page                         

  1 / 16276 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29522533
[Au] Autor:Kasai N; Kondo O; Suzuki K; Aoki Y; Ishii N; Goto M
[Ad] Address:Department of Otolaryngology, National Sanatorium Oku-Komyoen, Setouchi City, Okayama, Japan.
[Ti] Title:Quantitative evaluation of maxillary bone deformation by computed tomography in patients with leprosy.
[So] Source:PLoS Negl Trop Dis;12(3):e0006341, 2018 Mar 09.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Facial deformation as a sequela of leprosy is caused not only by a saddle nose but also by regression of the maxilla, as well documented in paleopathological observations of excavated skeletal remains of patients with leprosy. However, maxillary changes in living patients have been evaluated only by the subjective visual grading. Here, we attempted to evaluate maxillary bone deformation in patients with leprosy using three-dimensional computed tomography (3D-CT). METHODS: Three-dimensional images centered on the maxilla were reconstructed using multiplanar reconstruction methods in former patients with leprosy (n = 10) and control subjects (n = 5); the anterior-posterior length of the maxilla (MA-P) was then measured. The difference between the MA-P of the patients and those of controls was evaluated after compensating for individual skull size. These findings were also compared with those from previous paleopathological studies. FINDINGS: Three former patients with lepromatous leprosy showed marked atrophy of the maxilla at the prosthion (-8.6, -11.1 and -17.9 mm) which corresponded with the visual appearance of the maxillary deformity, and these results were consistent with paleopathological findings of excavated skeletal remains. Additionally, the precise bone defects of the maxilla could be individually calculated for accurate reconstructive surgery. INTERPRETATION: We have successfully illustrated maxillary bone deformities in living patients with leprosy. This study also confirmed the maxillary regression described in paleopathological studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1371/journal.pntd.0006341

  2 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29436199
[Au] Autor:Kim HJ; Yoo J; Jung SM; Song JJ; Park YB; Lee SW
[Ad] Address:Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
[Ti] Title:Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis.
[So] Source:Yonsei Med J;59(2):294-302, 2018 Mar.
[Is] ISSN:1976-2437
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:PURPOSE: We investigated whether red blood cell distribution width (RDW) predicts vasculitis activity based on Birmingham vasculitis activity score (BVAS) or BVAS for granulomatosis with polyangiitis (GPA) at diagnosis and poor prognosis during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). MATERIALS AND METHODS: We reviewed the medical records of 150 patients with AAV. We defined severe GPA as BVAS for GPA ≥7 (the highest quartile). Correlation and standardised correlation coefficients were analysed by linear regression tests. The differences between groups were evaluated by Mann-Whitney test. Relative risk (RR) was assessed by chi square test and Cox hazards model. RESULTS: RDW was correlated only with the vasculitis activity of GPA among patients with AAV. An increase in RDW was associated with the absence of ear nose throat (ENT) manifestation, but not proteinase 3-ANCA. Significant differences were noted in cumulative refractory free survival according to RDW ≥15.4% (p=0.007) and the absence of ENT manifestation (p=0.036). Multivariate Cox hazards analysis identified RDW ≥15.4% as the only significant predictor of refractory disease in GPA (RR 17.573). CONCLUSION: RDW predicts vasculitis activity in GPA, and RDW ≥15.4% at diagnosis may increase the risk of severe GPA at diagnosis and predict refractory diseases during follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.3349/ymj.2018.59.2.294

  3 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29401275
[Au] Autor:Cope JR; Murphy J; Kahler A; Gorbett DG; Ali I; Taylor B; Corbitt L; Roy S; Lee N; Roellig D; Brewer S; Hill VR
[Ad] Address:Waterborne Disease Prevention Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Title:Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation.
[So] Source:Clin Infect Dis;66(4):548-553, 2018 Feb 01.
[Is] ISSN:1537-6591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background: Naegleria fowleri is a thermophilic ameba found in freshwater that causes primary amebic meningoencephalitis (PAM) when it enters the nose and migrates to the brain. Patient exposure to water containing the ameba typically occurs in warm freshwater lakes and ponds during recreational water activities. In June 2016, an 18-year-old woman died of PAM after traveling to North Carolina, where she participated in rafting on an artificial whitewater river. Methods: We conducted an epidemiologic and environmental investigation to determine the water exposure that led to the death of this patient. Results: The case patient's most probable water exposure occurred while rafting on an artificial whitewater river during which she was thrown out of the raft and submerged underwater. The approximately 11.5 million gallons of water in the whitewater facility were partially filtered, subjected to ultraviolet light treatment, and occasionally chlorinated. Heavy algal growth was noted. Eleven water-related samples were collected from the facility; all were positive for N. fowleri. Of 5 samples collected from the nearby natural river, 1 sediment sample was positive for N. fowleri. Conclusions: This investigation documents a novel exposure to an artificial whitewater river as the likely exposure causing PAM in this case. Conditions in the whitewater facility (warm, turbid water with little chlorine and heavy algal growth) rendered the water treatment ineffective and provided an ideal environment for N. fowleri to thrive. The combination of natural and engineered elements at the whitewater facility created a challenging environment to control the growth of N. fowleri.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/cid/cix810

  4 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29309618
[Au] Autor:Muehling LM; Turner RB; Brown KB; Wright PW; Patrie JT; Lahtinen SJ; Lehtinen MJ; Kwok WW; Woodfolk JA
[Ad] Address:Department of Medicine, University of Virginia School of Medicine, Charlottesville.
[Ti] Title:Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans.
[So] Source:J Infect Dis;217(3):381-392, 2018 Jan 17.
[Is] ISSN:1537-6613
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background: Little is known about T cells that respond to human rhinovirus in vivo, due to timing of infection, viral diversity, and complex T-cell specificities. We tracked circulating CD4+ T cells with identical epitope specificities that responded to intranasal challenge with rhinovirus (RV)-A39, and we assessed T-cell signatures in the nose. Methods: Cells were monitored using a mixture of 2 capsid-specific major histocompatibility complex II tetramers over a 7-week period, before and after RV-A39 challenge, in 16 human leukocyte antigen-DR4+ subjects who participated in a trial of Bifidobacterium lactis (Bl-04) supplementation. Results: Pre-existing tetramer+ T cells were linked to delayed viral shedding, enriched for activated CCR5+ Th1 effectors, and included a minor interleukin-21+ T follicular helper cell subset. After RV challenge, expansion and activation of virus-specific CCR5+ Th1 effectors was restricted to subjects who had a rise in neutralizing antibodies, and tetramer-negative CCR5+ effector memory types were comodulated. In the nose, CXCR3-CCR5+ T cells present during acute infection were activated effector memory type, whereas CXCR3+ cells were central memory type, and cognate chemokine ligands were elevated over baseline. Probiotic had no T-cell effects. Conclusions: We conclude that virus-specific CCR5+ effector memory CD4+ T cells primed by previous exposure to related viruses contribute to the control of rhinovirus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/infdis/jix514

  5 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29260782
[Au] Autor:Shakhova NV; Kamaltynova EM; Lobanov YF; Ardatova TS; Nikolaeva KS
[Ad] Address:Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia, 656038.
[Ti] Title:Rasprostranennost' i faktory riska allergicheskogo rinita sredi detei doshkol'nogo vozrasta. [The prevalence and risk factors of allergic rhinitis among the children of the preschool age].
[So] Source:Vestn Otorinolaringol;82(6):47-51, 2017.
[Is] ISSN:0042-4668
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The objective of the present work was to estimate the prevalence and risk factors of the development of allergic rhinitis among the children at the age from 3 to 6 years. The cross-sectional study was carried out in five cities of the Altai region during the period from 2015 to 2016. The prevalence of allergic rhinitis was evaluated with the use of the Russian language version of the ISAAC questionnaire filled up by the parents of the children. A child whose parents answered in the affirmative to the question 'Did your child have the runny nose, nasal congestion, and/or sneezing in the absence of cold symptoms and acute viral infection during the last 12 months?' were considered to be suffering from active allergic rhinitis (AAR). The risk factors for the development of this condition were identified with the use of an additional questionnaire. A total of 3205 filled questionnaires were available for the analysis. Based on the data obtained, the prevalence of active allergic rhinitis among the study population was estimated at 18.0% (n=577). 243 (42.1%) of these children presented with the symptoms of conjunctivitis. Therefore, the prevalence of active allergic rhinoconjunctivitis (ARC appears to be 7.5% (n=243). In fact, the medically verified diagnosis of allergic rhinitis was established only in 6.4% (n=204) children of the 577 ones having AAR. The family history of allergic rhinitis was shown to increase the risk of development of AAR by 2.6 times (OR=2.63 , 95%; CI=2.16-3.19; p<0.01) and that of ARC by 2.8 times (OR=2.85, 95%; CI=2.16-3.75; p<0.01). Masculine gender was found to increase the risk of development of both AAR an ARC by 1.3 times (OR=1.35, 95%; CI=1.01-1.37; p<0.05) and (OR=1.35, 95%; CI=1.03-1.76; p<0.05) respectively. The actual prevalence of active allergic rhinitis was significantly higher than the frequency of the medically verified diagnoses of this condition. It is concluded that the family history of allergic diseases and the masculine gender considerably increase the risk of development of both AAR and AFC.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.17116/otorino201782647-51

  6 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28470359
[Au] Autor:Topuz MF; Sari M; Binnetoglu A; Dogrul R; Bugdayci O; Seker A
[Ad] Address:Department of Otorhinolaryngology, Dumlupinar University School of Medicine, Istiklal Parish Okmeydani st. No: 10 Merkez, Kütahya, Turkey. drfatihtopuz@yahoo.com.
[Ti] Title:Is endoscopic endonasal transsphenoidal surgery increases the susceptibility to rhinosinusitis.
[So] Source:Eur Arch Otorhinolaryngol;274(8):3065-3069, 2017 Aug.
[Is] ISSN:1434-4726
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The aim of the study was to analyze whether the measurement of changes in the anatomical position and volume of middle concha, the volume changes in the area between the middle concha and lamina papyracea, the evaluation of opacification in major paranasal sinuses, and osteomeatal complex occlusion in cases with middle concha by out-fracture technique during endoscopic endonasal transsphenoidal approach is a minimally invasive surgery, and also to find out whether these changes lead to the development of tendency to rhinosinusitis. It was a retrospective clinical study. Forty-five cases, between 2013 and 2015, planned for endoscopic endonasal transsphenoidal surgery due to hypophyseal pathology at the Neurosurgery Departments of Marmara University Hospital were evaluated retrospectively. The patients were evaluated for the changes in the anatomy of the middle concha and the effects of these changes to paranasal sinuses by paranasal computed tomographies were studied at the preoperative second week and postoperative 12 month. The Lund-Mackay scoring system was used for the evaluation of opacification in the five major paranasal sinuses and occlusion of the osteomeatal complex in the pre- and postoperative period. The Lund-Mackay scoring system was used to analyze the paranasal computed tomography of the patients at the preoperative 2 weeks and postoperative first year. According to the Lund-Mackay scoring system, no significant difference was detected between the preoperative and postoperative opacification of paranasal sinuses (p > 0.05). Besides, there was also no significant difference between the preoperative and postoperative osteomeatal complex occlusion (p > 0.05). Considering the distance between middle concha and lamina papyracea following the out-fracture of the middle concha, a significant lateralization of 0.5 mm between the preoperative and postoperative period was observed (p < 0.05). In addition, a significant change was also detected in the volume of middle concha (p < 0.05). The volume of the area between the middle concha and lamina papyracea was decreased with a statistical significance (p < 0.05). The endoscopic endonasal transsphenoidal surgery causes some variations in the structures of the middle concha, paranasal sinuses, and OMC, but these changes do not lead to significant rhinologic pathologies.
[Mh] MeSH terms primary: Natural Orifice Endoscopic Surgery
Rhinitis/etiology
Sinusitis/etiology
[Mh] MeSH terms secundary: Adult
Aged
Disease Susceptibility
Female
Humans
Male
Middle Aged
Natural Orifice Endoscopic Surgery/adverse effects
Nose
Paranasal Sinuses/diagnostic imaging
Pituitary Diseases/surgery
Retrospective Studies
Sphenoid Bone
Turbinates/diagnostic imaging
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4598-4

  7 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29507021
[Au] Autor:Beltrami D; Guilcher P; Longchamp D; Crisinel PA
[Ad] Address:Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
[Ti] Title:Meningococcal serogroup W135 epiglottitis in an adolescent patient.
[So] Source:BMJ Case Rep;2018, 2018 Mar 05.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Acute epiglottitis is a severe and potentially life-threatening condition. Since the implementation of vaccination, the number of cases of epiglottitis has decreased and the proportion of other infectious causes has increased. We report a case of acute epiglottitis in a teenager caused by , an unusual pathogen.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process

  8 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29256426
[Au] Autor:Elfadl AK; Lee SW; Kim JH; Lee KL; Arif Ullah HM; Chung MJ; Ghim SG; Lee EJ; Kim YD; Kim SM; Jeon SG; Lim JH; Choi HJ; Park JK; Jeong KS
[Ad] Address:Department of Pathology, Faculty of Veterinary Medicine, Kyungpook National University, Republic of Korea.
[Ti] Title:Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: a case report.
[So] Source:Dis Aquat Organ;127(1):41-47, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A 5 yr old, 184 kg, and 262 cm total length female bottlenose dolphin Tursiops truncatus was found dead in a display after bloody discharge from the blowhole was observed 3 h prior to death. Pathological examination revealed fibrinous bronchopneumonia with prominent areas of necrosis (sequestra) and numerous Gram-negative bacilli within alveoli and in blood vessels of the lungs and liver and between muscle fibers. The cause of death was attributed to septicemia. Often, cases of fibrinous bronchopneumonia are characterized by bacteremia in the latter stages of infection, resulting in the death of the animal. Septicemia likely accounts for the ecchymoses and petechiae noted on the spleen, pancreas, forestomach, lungs, visceral peritoneum, and small intestine. Additional lesions included hemothorax, stable red frothy fluid in the trachea, and lymphoid depletion in the spleen and lymph nodes. Pure growth of Morganella morganii was isolated from the lungs, blood, liver, and blowhole mucosa. Sequencing of 16s rRNA of the isolated bacteria showed more than 99.6% identity with M. morganii strain FDAARGOS_172. To our knowledge, this is the first report of fatal fibrinonecrotizing bronchopneumonia associated with M. morganii infection in a cetacean.
[Mh] MeSH terms primary: Bottle-Nosed Dolphin
Bronchopneumonia/veterinary
Enterobacteriaceae Infections/veterinary
Morganella morganii/isolation & purification
[Mh] MeSH terms secundary: Animals
Bronchopneumonia/microbiology
Bronchopneumonia/pathology
Enterobacteriaceae Infections/microbiology
Enterobacteriaceae Infections/pathology
Fatal Outcome
Female
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03184

  9 / 16276 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29363975
[Au] Autor:Ruiz SI; Bowen LE; Bailey MM; Berkland C
[Ad] Address:United States Army Medical Research Institute of Infectious Diseases , Fort Detrick , Maryland 21702 , United States.
[Ti] Title:Pulmonary Delivery of Ceftazidime for the Treatment of Melioidosis in a Murine Model.
[So] Source:Mol Pharm;15(3):1371-1376, 2018 Mar 05.
[Is] ISSN:1543-8392
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Burkholderia pseudomallei, the etiological agent responsible for melioidosis, exhibits a great public health toll in its endemic regions. The elevation of B. pseudomallei to a Tier I select agent underscores the urgent need for effective therapeutics and preventatives. The current treatment regimen for melioidosis is suboptimal, requiring an intensive phase of intravenous antibiotic followed by months of oral antibiotics. Inhaled antibiotics are a promising avenue to pursue for pulmonary diseases, including melioidosis, since this mode of delivery mimics the likely exposure route and can provide high drug doses directly to the infected tissue. Ceftazidime was delivered via a nose-only system to BALB/c mice challenged with B. pseudomallei. Mice treated with nebulized ceftazidime became symptomatic but survived until study end, which was comparable to those treated intraperitoneally. Upon necropsy, bacteria remained within the spleens of the majority of the experimental animals. The effectiveness of nebulized ceftazidime warrants additional studies to improve the treatment regimen and to test as a prophylactic therapy against B. pseudomallei.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.molpharmaceut.7b00938

  10 / 16276 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29500223
[Au] Autor:Bennion DM; Jones CH; Dang AN; Isenberg JD; Graham JT; Lindblad L; Domenig O; Waters MF; Poglitsch M; Sumners C; Steckelings UM
[Ad] Address:University of Florida, Department of Physiology and Functional Genomics, PO Box 100274, M-552, Gainesville, Florida, 32610, United States.
[Ti] Title:Protective Effects of the Angiotensin II AT Receptor Agonist Compound 21 in Ischemic Stroke: A Nose-to-Brain Delivery Approach.
[So] Source:Clin Sci (Lond);, 2018 Mar 02.
[Is] ISSN:1470-8736
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Significant neuroprotective effects of angiotensin II type 2 (AT ) receptor agonists in ischemic stroke have been previously demonstrated in multiple studies.  However, the routes of agonist application used in these pre-clinical studies, direct intracerebroventricular and systemic administration, are unsuitable for translation to humans; in the latter case because AT receptor agonists are blood brain barrier (BBB) impermeable. To circumvent this problem, in the current study we utilized the nose-to-brain (N2B) route of administration to bypass the blood brain barrier and deliver the selective AT receptor agonist Compound 21 (C21) to naïve rats or rats that had undergone endothelin 1-induced ischemic stroke.  The results obtained from this study indicated that C21 applied N2B entered the cerebral cortex and striatum within 30 mins in amounts that are therapeutically relevant (8.4 - 9nM), regardless of whether the BBB was intact or disintegrated. C21 first applied N2B at 1.5 hours after stroke indeed provided neuroprotection, as evidenced by a highly significant, 57% reduction in cerebral infarct size and significant improvements in Bederson and Garcia neurological scores.  N2B-administered C21 did not affect blood pressure or heart rate.  Thus, these data provide proof-of-principle for the idea that N2B application of an AT receptor agonist can exert neuroprotective actions when administered following ischemic stroke.  Since N2B delivery of other agents has been shown to be effective in certain human central nervous system diseases, then N2B application of AT receptor agonists may become a viable mode of delivering these neuroprotective agents for human ischemic stroke patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher


page 1 of 1628 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information