Database : MEDLINE
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  1 / 2096 MEDLINE  
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[PMID]: 29078747
[Au] Autor:Jing Q; Chen J; Chen J; Tang Y; Lu Y; Jiang Y
[Ad] Address:Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, 83 Fenyang Rd, Shanghai, 20031, China.
[Ti] Title:Cionni-modified capsular tension ring for surgical repair of cyclodialysis after trabeculectomy: a case report.
[So] Source:BMC Ophthalmol;17(1):196, 2017 Oct 27.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To report a case for repair of cyclodialysis after trabeculectomy with Cionni-modified capsular tension ring. CASE PRESENTATION: A 64-year-old man who had undergone trabeculectomy of his left eye 3 months earlier visited our clinic owing to blurred vision. His visual acuity was 20/2000 and the intraocular pressure (IOP) was 6 mmHg. Slit-lamp examination showed a shallow anterior chamber and dense cataract. Ultrasound biomicroscopy revealed 360 ° detachment of the ciliary body and suspected cyclodialysis of the trabeculectomy incision. Choroidal detachment was confirmed by B-scan ultrasonography and optical coherence tomography. Phacoemulsification was performed in which a foldable intraocular lens (IOL) was implanted in the capsular bag and a Cionni-modified capsular tension ring (MCTR) was inserted into the ciliary sulcus. The maximum focal point of the MCTR was rotated to the site of the most severe cyclodialysis and the MCTR was sutured to the sclera through its two eyelets. The patient's best-corrected visual acuity improved to 30/50 and the IOP increased to 16 mmHg after surgery. Gonioscopy and ultrasound biomicroscopy confirmed closure of the cyclodialysis and resolution of choroidal detachment. CONCLUSIONS: Phacoemjulsification with implantation of an intraocular lens combined with insertion of an MCTR into the ciliary sulcus appears to be a relatively safe, effective, minimally invasive method for repairing cyclodialysis in cataract patients. Although the technique yielded good results and appeared to be safe in one patient, further studies are necessary to validate the findings on more patients and with a long-term follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:In-Process
[do] DOI:10.1186/s12886-017-0582-4

  2 / 2096 MEDLINE  
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[PMID]: 29069012
[Au] Autor:Zaleska-Zmijewska A; Janiszewski M; Wawrzyniak ZM; Kuch M; Szaflik J; Szaflik JP
[Ad] Address:aDepartment of Ophthalmology, SPKSO Ophthalmic Hospital bDepartment of Heart Failure and Cardiac Rehabilitation, Second Faculty of Medicine, Medical University of Warsaw cFaculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw dDepartment of Cardiology, Hypertension and Internal Diseases, Second Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
[Ti] Title:Is atrial fibrillation a risk factor for normal-tension glaucoma?
[So] Source:Medicine (Baltimore);96(43):e8347, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Glaucoma (GL) and atrial fibrillation (AF) are diseases of significant social importance. Cardiovascular disorders such as systemic hypertension, hypotension, increased blood viscosity, vasospasm, and diabetes are potential risk factors of GL, especially when intraocular pressure is not elevated. Only a few studies have reported a possible connection between cardiac arrhythmias and GL. The purpose of this study was to evaluate the risk of GL in patients with AF.A total of 117 patients were included in the study, 79 with AF (AF group) and 38 with sinus rhythm (Control group), matched for age and sex. The mean ±â€Šstandard deviation age was 73.6 ±â€Š7.2 and 71.6 ±â€Š4.7 years for the AF and control groups, respectively. There were no statistically significant differences in the percentage of systemic hypertension, congestive heart failure, diabetes mellitus type 2, or vascular disease between the groups. Patients were examined for the presence of normal-tension glaucoma (NTG) by an ophthalmologist.NTG was confirmed in 40 patients (34.2%) in the entire group, with 35 (44.3%) in the AF group and 5 (13.15%) in the Control group. The incidence of NTG was significantly higher in the AF group (P = .0221). Women represented 60% of GL patients in the AF group and 80% in the control group. There were no significant differences in intraocular pressure between the groups (mean ±â€Šstandard deviation, 14.3 ±â€Š2.3 vs. 14.2 ±â€Š2.8 mmHg, P = .4202). Approximately three-fourths of patients with AF and NTG had early visual field damage based on the Hodapp classification.AF, independent of other known cardiovascular risk factors, increases the risk of developing NTG. Many AF patients do not have conspicuous symptoms of GL, so understanding the possible risk of its development is critical because early detection might help to prevent later visual impairment and even irreversible blindness.
[Mh] MeSH terms primary: Atrial Fibrillation
Low Tension Glaucoma
Vision Disorders
[Mh] MeSH terms secundary: Aged
Atrial Fibrillation/diagnosis
Atrial Fibrillation/epidemiology
Atrial Fibrillation/physiopathology
Early Diagnosis
Early Medical Intervention/methods
Female
Humans
Intraocular Pressure/physiology
Low Tension Glaucoma/complications
Low Tension Glaucoma/diagnosis
Low Tension Glaucoma/epidemiology
Low Tension Glaucoma/physiopathology
Male
Poland/epidemiology
Risk Assessment
Risk Factors
Statistics as Topic
Tonometry, Ocular/methods
Vision Disorders/etiology
Vision Disorders/prevention & control
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171123
[Lr] Last revision date:171123
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008347

  3 / 2096 MEDLINE  
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[PMID]: 28801699
[Au] Autor:Kaplowitz K; Tsai JC
[Ad] Address:Loma Linda VA, Loma Linda University, 11201 Benton St, Loma, Linda, CA, 92357, USA.
[Ti] Title:Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(11):2295, 2017 11.
[Is] ISSN:1435-702X
[Cp] Country of publication:Germany
[La] Language:eng
[Mh] MeSH terms primary: Fluorouracil
Intraocular Pressure
[Mh] MeSH terms secundary: Glaucoma
Glaucoma Drainage Implants
Humans
Injections
Ocular Hypotension
Postoperative Complications
Treatment Outcome
[Pt] Publication type:LETTER; COMMENT
[Nm] Name of substance:U3P01618RT (Fluorouracil)
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[Js] Journal subset:IM
[Da] Date of entry for processing:170813
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3769-8

  4 / 2096 MEDLINE  
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[PMID]: 28751182
[Au] Autor:Rodríguez-Navarro Á; Gonzalez-Valverde FM
[Ad] Address:Department of Anaesthesia and Critical Care, Reina Sofia General University Hospital, Murcia, Spain.
[Ti] Title:Unilateral blindness after orthognathic surgery: hypotensive anaesthesia is not the primary cause.
[So] Source:Int J Oral Maxillofac Surg;, 2017 Jul 24.
[Is] ISSN:1399-0020
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Perioperative vision loss in non-ocular surgery represents a rare but devastating complication and multiple causes have been proposed. Any portion of the visual system may be involved and several authors have tried to relate that complication with deliberate hypotension anaesthetic technique, used to control intraoperative bleeding. We report a patient operated for orthognathism who suffered unilateral blindness. After review of similar cases, we can state that the transmission of forces generated during Le fort I osteotomy is related to the complication. This osteotomy technique is regularly performed in our hospital using a curved osteotome to achieve the pterygomaxillary disjunction and the adverse transmission of forces via the sphenoid bone is the main reason for indirect damage to the optic nerve and its vascular structures causing the neuropathy and blindness. Hypotensive anaesthesia may certainly lead to transient ischaemia but only in specific cases because of decreased ocular perfusion pressured.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170728
[Lr] Last revision date:170728
[St] Status:Publisher

  5 / 2096 MEDLINE  
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[PMID]: 28723783
[Au] Autor:Tang J; Du E; Wang J
[Ad] Address:Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
[Ti] Title:Novel surgical management of cyclodialysis cleft via anterior chamber perfusion: Case report.
[So] Source:Medicine (Baltimore);96(29):e7559, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Cyclodialysis cleft is a relatively rare but severe condition with persistent ocular hypotony, which can cause morphologic changes and visual loss. Here we report a case of a traumatic cyclodialysis cleft that was successfully managed with direct cyclopexy via anterior chamber perfusion. During the operation, if there is aqueous humor flowing out of the deep scleral incision, the cleft is not closed, and surgery should continue until there is no aqueous outflow. PATIENT CONCERNS: A 66-year-old man was treated for severe blunt ocular trauma of the left eye and a resultant cyclodialysis cleft, lens subluxation, choroidal detachment and a cataract. His intraocular pressure was 6 mm Hg, he presented with a shallow anterior chamber, phacodonesis, iridodonesis, 360° ciliary body detachment, and a suspicious cyclodialysis cleft in the 5 to 8 o'clock position. DIAGNOSES:: ocular blunt trauma (left eye), cyclodialysis cleft (left eye), lens subluxation (left eye), choroidal detachment (left eye), cataract (both eyes). INTERVENTIONS: The cataract was extracted by phacoemulsification and a posterior chamber intraocular lens was implanted with 2 capsular tension rings, one in the lens bag and the other in the ciliary sulcus. Throughout the following month, intraocular pressure fluctuated between 4 and 6 mm Hg and the ciliary body failed to reattach. A cyclopexy via anterior chamber perfusion was thus deemed necessary and performed. OUTCOMES: After cyclopexy, intraocular pressure increased to 27 mm Hg and decreased to 16 mm Hg after brinzolamide eye drops treatment twice daily for 4 days. Subsequently intraocular pressure stabilized between 10 to 21mm Hg. Complete closure of the cyclodialysis cleft was confirmed with ultrasound biomicroscopy. LESSONS: Cyclopexy via anterior chamber perfusion for patients with cyclodialysis cleft is a simple, safe, and efficient technique that ensures a successful surgery.
[Mh] MeSH terms primary: Anterior Chamber/surgery
Eye Injuries/complications
Ocular Hypotension/surgery
[Mh] MeSH terms secundary: Aged
Anterior Chamber/diagnostic imaging
Anterior Chamber/drug effects
Cataract/complications
Cataract/diagnosis
Cataract/drug therapy
Cataract Extraction
Choroid Diseases/diagnosis
Choroid Diseases/drug therapy
Choroid Diseases/etiology
Choroid Diseases/surgery
Eye Injuries/diagnosis
Eye Injuries/drug therapy
Humans
Lens Implantation, Intraocular
Male
Ocular Hypotension/diagnosis
Ocular Hypotension/drug therapy
Ocular Hypotension/etiology
Postoperative Complications/diagnostic imaging
Postoperative Complications/drug therapy
Postoperative Complications/surgery
Wounds, Nonpenetrating/complications
Wounds, Nonpenetrating/diagnosis
Wounds, Nonpenetrating/drug therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170808
[Lr] Last revision date:170808
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170721
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007559

  6 / 2096 MEDLINE  
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[PMID]: 28692596
[Au] Autor:Berk TA; An JA; Ahmed IIK
[Ad] Address:*Department of Ophthalmology, McGill University, Montréal, QC ‡Department of Ophthalmology and Vision Sciences, University of Toronto Faculty of Medicine, Toronto §Trillium Health Partners, Mississauga ∥Prism Eye Institute, Mississauga, ON, Canada †Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO.
[Ti] Title:Inadvertent Cyclodialysis Cleft and Hypotony Following Ab-Interno Trabeculotomy Using the Trabectome Device Requiring Surgical Repair.
[So] Source:J Glaucoma;26(8):742-746, 2017 Aug.
[Is] ISSN:1536-481X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the first case of inadvertent cyclodialysis cleft and hypotony requiring surgical repair following ab-interno trabeculotomy (AIT) using the Trabectome device, and the postoperative clinical results following direct suture cyclopexy. METHODS: A 55-year-old man with hypotonous maculopathy secondary to cyclodialysis cleft inadvertently created 3 years earlier during AIT using the Trabectome device was referred for repair. Direct suture cyclopexy was performed and topical homatropine and dexamethasone drops were prescribed postoperatively. RESULTS: Gonioscopic examination revealed complete cleft closure on postoperative day 1 confirmed by anterior segment optical coherence tomography. At 11 weeks postoperatively, visual acuity had improved from 20/400 to 20/40, with resolution of preoperative macular folds on fundoscopic examination. At 9 months postoperatively, visual acuity had further improved to 20/20 with intraocular pressure stable at 9 mm Hg maintained on travoprost and brimonidine. CONCLUSIONS: Inadvertent cyclodialysis cleft from a malpositioned AIT and resultant hypotony is rare and in this case was successfully treated by direct suture cyclopexy.
[Mh] MeSH terms primary: Ciliary Body/injuries
Eye Injuries/etiology
Ocular Hypotension/etiology
Sclera/injuries
Trabeculectomy/adverse effects
[Mh] MeSH terms secundary: Ciliary Body/pathology
Eye Injuries/diagnosis
Eye Injuries/surgery
Glaucoma, Open-Angle/surgery
Gonioscopy
Humans
Iatrogenic Disease
Intraocular Pressure/physiology
Male
Middle Aged
Ocular Hypotension/diagnosis
Ocular Hypotension/surgery
Sclera/pathology
Tomography, Optical Coherence
Tonometry, Ocular
Trabeculectomy/instrumentation
Visual Acuity/physiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170711
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000719

  7 / 2096 MEDLINE  
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[PMID]: 28660275
[Au] Autor:Jasien JV; Huisingh C; Girkin CA; Downs JC
[Ad] Address:Vision Science Graduate Program, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States.
[Ti] Title:The Magnitude of Hypotony and Time Course of Intraocular Pressure Recovery Following Anterior Chamber Cannulation in Nonhuman Primates.
[So] Source:Invest Ophthalmol Vis Sci;58(7):3225-3230, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: To determine the magnitude of ocular hypotony and the length of recovery time to 6 and 10 mm Hg IOP following anterior chamber (AC) cannulation. Methods: Bilateral IOP was recorded 500 times per second via telemetry immediately before, during, and immediately after AC cannulation with a 27-G needle in 10 different sessions at least 2 weeks apart in four male rhesus macaques (nonhuman primates; NHPs) aged 3- to 6-years old. Bilateral IOP was recorded continuously using a proven telemetry system while the NHPs were under general anesthesia during IOP transducer calibration experiments involving manometric control of IOP via AC cannulation, then continuously after the AC needles were removed until IOP recovered to precannulation levels. The change in IOP from baseline to AC cannulation was tested using the signed-rank test. The times necessary for IOP to recover to 6 and 10 mm Hg, respectively, were calculated. Results: Average precannulation IOP was 11.5 mm Hg and significantly decreased to an average of 2.3 mm Hg immediately following AC needle removal (P = 0.0156). On average, IOP recovered from 2.3 to 6 and 10 mm Hg in 32.4 and 63.7 minutes, respectively. Recovery times of IOP were not affected by repeated AC cannulations every 2 weeks. Conclusions: Generally, IOP recovers relatively quickly after repeated AC cannulation, and did not result in extended duration hypotony. It is important to consider hypotony in animal experiments and clinical procedures involving AC cannulation and paracentesis when consideration of IOP or its effects is important.
[Mh] MeSH terms primary: Anterior Chamber/physiopathology
Catheterization
Intraocular Pressure/physiology
Ocular Hypotension/physiopathology
[Mh] MeSH terms secundary: Animals
Disease Models, Animal
Macaca mulatta
Recovery of Function/physiology
Regression Analysis
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[Js] Journal subset:IM
[Da] Date of entry for processing:170630
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21833

  8 / 2096 MEDLINE  
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[PMID]: 28624324
[Au] Autor:Chan TCW; Bala C; Siu A; Wan F; White A
[Ad] Address:University of Sydney, Sydney, Australia.
[Ti] Title:Risk Factors for Rapid Glaucoma Disease Progression.
[So] Source:Am J Ophthalmol;180:151-157, 2017 Aug.
[Is] ISSN:1879-1891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To determine the intraocular and systemic risk factor differences between a cohort of rapid glaucoma disease progressors and nonrapid disease progressors. DESIGN: Retrospective case-control study. METHODS: Setting: Five private ophthalmology clinics. STUDY POPULATION: Forty-eight rapidly progressing eyes (progression ≥1 dB mean deviation [MD]/year) and 486 non-rapidly progressing eyes (progression <1 dB MD/year). Patients were eligible if they had a diagnosis of glaucoma from their ophthalmologist and if they had greater than or equal to 5 Humphrey visual fields (24-2) conducted. Patients were excluded if their sequential visual fields showed an improvement in MD or if they had greater than 5 dB MD variation in between visits. Patients with obvious neurologic fields were excluded. OBSERVATION PROCEDURE: Clinical and demographic data (age, sex, central corneal thickness [CCT], intraocular pressure [IOP], refraction, medications), as well as medical, surgical, and ocular histories, were collected. MAIN OUTCOME MEASURES: Risk factor differences between the cohorts were measured using the independent t test, Wald χ , and binomial regression analysis. RESULTS: Rapid progressors were older, had significantly lower CCT and baseline IOPs, and were more likely to have pseudoexfoliation, disc haemorrhages, ocular medication changes, and IOP-lowering surgery. They also had significantly higher rates of cardiovascular disease and hypotension. Subjects with cardiovascular disease were 2.33 times more likely to develop rapidly progressive glaucoma disease despite significantly lower mean and baseline IOPs. CONCLUSION: Cardiovascular disease is an important risk factor for rapid glaucoma disease progression irrespective of IOP control.
[Mh] MeSH terms primary: Cardiovascular Diseases/epidemiology
Glaucoma/diagnosis
Glaucoma/epidemiology
[Mh] MeSH terms secundary: Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Cornea/pathology
Disease Progression
Exfoliation Syndrome/epidemiology
Female
Humans
Intraocular Pressure/physiology
Male
New South Wales/epidemiology
Optic Disk/pathology
Retinal Hemorrhage/epidemiology
Retrospective Studies
Risk Factors
Visual Fields
[Pt] Publication type:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Entry month:1708
[Cu] Class update date: 170804
[Lr] Last revision date:170804
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170619
[St] Status:MEDLINE

  9 / 2096 MEDLINE  
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[PMID]: 28615113
[Au] Autor:Tseng VL; Kim CH; Romero PT; Yu F; Robertson-Brown KW; Phung L; Raygoza D; Caprioli J; Coleman AL
[Ad] Address:Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
[Ti] Title:Risk Factors and Long-Term Outcomes in Patients with Low Intraocular Pressure after Trabeculectomy.
[So] Source:Ophthalmology;124(10):1457-1465, 2017 Oct.
[Is] ISSN:1549-4713
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To examine risk factors for low intraocular pressure (IOP) after trabeculectomy and to describe long-term outcomes in these eyes. DESIGN: Retrospective case-control study. PARTICIPANTS: Cases with low IOP included all patients with IOP ≤5 mmHg on 3 or more consecutive visits 3 months or later after trabeculectomy. Control patients without low IOP after trabeculectomy were randomly selected at a 1:2 case-to-control ratio. METHODS: A case-control study was performed of patients undergoing trabeculectomy at the Stein Eye Institute. Covariates included demographics, history of cataract surgery, refractive error, number of glaucoma medications, family history of glaucoma, diabetes, hypertension, visual acuity (VA), IOP, number of sutures in the scleral flap, laser suture lysis, surgeon, and laterality of surgery. Logistic regression modeling was used to examine associations between each covariate and low IOP. Postoperative outcomes that were examined included reoperation, vision loss, and surgical failure. The time between trabeculectomy and each outcome was compared between cases and controls with Cox proportional hazards regression modeling. MAIN OUTCOME MEASURES: Low IOP after trabeculectomy, reoperation, vision loss, and surgical failure. RESULTS: Of 3659 total trabeculectomies performed by 5 surgeons between 1990 and 2013, 64 eyes had low IOP (1.7%), which were compared with 130 control eyes. Fifteen of the 64 eyes with low IOP had hypotony maculopathy (23.4%). After accounting for differences in baseline IOP, laser suture lysis was negatively correlated with low IOP after trabeculectomy (odds ratio [OR], 0.33; 95% confidence interval [CI], 0.13-0.87); surgeon was correlated with high vs. low IOP after trabeculectomy (OR, 5.32; 95% CI, 1.53-18.52). There were no statistically significant associations between low IOP and time to reoperation (hazard ratio [HR], 0.73; 95% CI, 0.32-1.68), vision loss (HR, 1.77; 95% CI, 0.81-3.88) or surgical failure (HR, 1.14; 95% CI, 0.62-2.11). In patients with low IOP, there was a higher unadjusted incidence of bleb revision in patients who had maculopathy (7.6 vs. 1.9 revisions/100 person-years; for maculopathy versus no maculopathy P = 0.008). CONCLUSIONS: The absence of laser suture lysis and surgeon are factors potentially associated with low IOP after trabeculectomy. Numeric hypotony does not necessarily represent clinical failure after trabeculectomy.
[Mh] MeSH terms primary: Intraocular Pressure/physiology
Ocular Hypotension/etiology
Postoperative Complications
Trabeculectomy
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Follow-Up Studies
Glaucoma, Open-Angle/surgery
Humans
Male
Middle Aged
Ocular Hypotension/physiopathology
Proportional Hazards Models
Reoperation
Retrospective Studies
Risk Factors
Tonometry, Ocular
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[Js] Journal subset:IM
[Da] Date of entry for processing:170616
[St] Status:MEDLINE

  10 / 2096 MEDLINE  
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[PMID]: 28604498
[Au] Autor:Lincoff NS; Buccilli A; Weinstock-Guttman B; Sieminski S; Gandhi S
[Ad] Address:Department of Neurology and Ophthalmology (NSL), State University of New York at Buffalo School of Medicine, Buffalo, New York; Jacobs MS Center (NSL, BW-G, SG), UBMD Neurology, State University of New York, Buffalo, New York; Ophthalmology Clinic (AB), Lockport, New York; and Ross Eye Institute (SS), University at Buffalo, Buffalo, New York.
[Ti] Title:Is Multiple Sclerosis Associated With a Lower Intraocular Pressure?
[So] Source:J Neuroophthalmol;37(3):265-267, 2017 Sep.
[Is] ISSN:1536-5166
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine if multiple sclerosis (MS) is associated with lower intraocular pressure (IOP) compared with individuals without MS. METHODS: Thirty patients with clinically definite MS were identified and a retrospective chart review was conducted. Each patient with MS underwent IOP recording by a single investigator using kinetic applanation tonometry. Measurement of central corneal thickness (CCT) also was obtained. Similarly, 30 study controls were identified and kinetic applanation tonometry and CCT were recorded. Univariate analysis of covariance was conducted to determine a statistically significant difference between IOP between MS and control groups, controlling for age. RESULTS: Analyses were adjusted for age and 2 subjects were excluded because of steroid use. The average IOP in MS group was 12.3 mm Hg (right eye = 12.3 mm Hg, left eye = 12.2 mm Hg) and in the control group was 17 mm Hg (right eye = 16.9 mm Hg, left eye = 17 mm Hg). There was a significant effect of presence of MS on IOP accounting for 53% variability in mean IOP (F(1,55) = 60.7; P < 0.001) when compared with the control group. CONCLUSIONS: This study demonstrated that IOP was significantly lower in patients with MS compared with controls. A more in-depth prospective study design is required, along with further investigation of possible etiologies. Identifying the mechanism of decreased IOP in patients with MS might allow development of new-targeted therapies for the treatment of glaucoma.
[Mh] MeSH terms primary: Intraocular Pressure/physiology
Multiple Sclerosis/complications
Ocular Hypotension/etiology
[Mh] MeSH terms secundary: Adult
Aged
Female
Humans
Male
Middle Aged
Multiple Sclerosis/physiopathology
Ocular Hypotension/diagnosis
Ocular Hypotension/physiopathology
Retrospective Studies
Tonometry, Ocular
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:170613
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000520


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