Database : MEDLINE
Search on : Oral and Submucous and Fibrosis [Words]
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[PMID]: 29523428
[Au] Autor:Hu Y; Qian Y; Lin L; Chen W; Yang L; Hu X; Tian K; Xia K; Su T
[Ad] Address:Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
[Ti] Title:Differential expression of organic cation transporter 3 in oral submucous fibrosis-associated buccal squamous cell carcinoma.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;, 2018 Mar 06.
[Is] ISSN:2212-4411
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to examine the expression of organic cation transporter 3 (OCT3) in patients with oral submucous fibrosis (OSF)-associated buccal squamous cell carcinoma (BSCC) and to explore its clinical significance. STUDY DESIGN: A total of 56 tissue specimens were collected from patients, among which there were 13 specimens with normal buccal mucosa (NBM), 13 with oral submucous fibrosis (OSF), 10 with OSF-associated BSCC (BSCC-OSF), 10 with well-differentiated BSCC (BSCC-I), and 10 with poorly to moderately differentiated BSCC (BSCC-II+III), based on pathologic examination. The expression of OCT3 was detected by using immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction. RESULTS: There was a significant difference in both the protein and mRNA expression levels of OCT3 among the NBM, OSF, BSCC-OSF, BSCC-I, and BSCC-II+III groups (protein: F = 82.45 [P < .0001]; mRNA: F = 50.69 [P < .0001]). The expression of OCT3 from NBM to OSF to BSCC-OSF was gradually upregulated. In addition, as BSCC became better differentiated, the expression of OCT3 increased. CONCLUSIONS: The expression of OCT3 was associated with OSF progression and the differentiation of BSCC. OCT3 expression may serve as a molecular marker for the prevention and early diagnosis of OSF and BSCC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 1185 MEDLINE  
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[PMID]: 29210111
[Au] Autor:Yu CC; Liao YW; Yu CH; Chang YC
[Ad] Address:Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
[Ti] Title:STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis.
[So] Source:J Oral Pathol Med;47(3):299-305, 2018 Mar.
[Is] ISSN:1600-0714
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:BACKGROUND: STRO-1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO-1 in areca quid chewing-associated oral submucous fibrosis (OSF). METHODS: Thirty OSF specimens and ten normal buccal mucosae were examined by immunohistochemistry. The activity of STRO-1 from fibroblasts cultured from normal buccal mucosa (BMFs) and OSF (OSFFs) were measureed and the effect of arecoline, a major areca nut alkaloid, on STRO-1 in BMFs was evaluated. Compared the activities between sorted STRO-1 cells and STRO-1 cells from OSFF were measured by collagen gel contraction, migration, invasion abilities, and the expression of α-smooth muscle actin (α-SMA) and pro-α1 (I) chain of type I collagen. RESULTS: Our results first showed that the expression of STRO-1 was more evident in areca quid chewing-associated OSF than normal buccal mucosa tissues (P < .05). Arecoline dose-dependently activated the level of STRO-1 in BMFs (P < .05). The relative expression of STRO-1 was significantly higher in OSFFs compared with BMFs (P < .05). In addition, the sorted STRO-1 cells from OSFFs exhibited higher collagen gel contraction, migration, and invasion abilities as well as elevated expression of α-SMA and pro-α1 (I) chain of type I collagen than the negative subset (P < .05). CONCLUSION: These findings suggested that the stemness marker STRO-1 may be a crucial factor in the pathogenesis of areca quid chewing-associated OSF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1111/jop.12668

  3 / 1185 MEDLINE  
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[PMID]: 29516926
[Au] Autor:Nadendla LK; Tatikonda VK; Bangi BB; Bhayya H; Devulapally RV; Pokala A
[Ad] Address:Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India.
[Ti] Title:Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis.
[So] Source:J Cancer Res Ther;14(2):394-397, 2018 Jan-Mar.
[Is] ISSN:1998-4138
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Background and Objectives: To evaluate the efficacy of ultrasonography (USG) as a noninvasive tool in assessing the severity of oral submucous fibrosis (OSMF) by measuring the submucosal thickness and also to correlate the sonographic changes with clinical staging. Materials and Methods: The submucosal thickness of the upper and lower labial mucosa, anterior and posterior portions of the right and left buccal mucosa were measured using ultrasound in 64 patients comprising of 32 OSMF patients and 32 controls. Among the controls, 16 were with a habit of chewing gutkha and 16 were without any habit history. Results: In OSMF group, four patients were with Stage I, 13 were with Stage II, 11 were with Stage III, and four with Stage IV. Results were analyzed by one-way analysis of variance for the significance of difference among the groups in submucosal thickness. As the stages of OSMF advanced, there was an increase in submucosal thickness of the buccal mucosa in the study group when compared with controls (P< 0.005). Conclusion: USG is an effective noninvasive zero radiation tool for assessing the progression of OSMF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.4103/0973-1482.183194

  4 / 1185 MEDLINE  
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[PMID]: 29405430
[Au] Autor:Arakeri G; Thomas D; Aljabab AS; Hunasgi S; Rai KK; Hale B; Fonseca FP; Gomez RS; Rahimi S; Merkx MAW; Brennan PA
[Ad] Address:Department of Oral and Maxillofacial Surgery, King Fahad Medical City, Riyadh, Saudi Arabia.
[Ti] Title:TFM classification and staging of oral submucous fibrosis: A new proposal.
[So] Source:J Oral Pathol Med;, 2018 Feb 05.
[Is] ISSN:1600-0714
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:BACKGROUND: We have evaluated the rationale of existing grading and staging schemes of oral submucous fibrosis (OSMF) based on how they are categorized. A novel classification and staging scheme is proposed. METHODS: A total of 300 OSMF patients were evaluated for agreement between functional, clinical, and histopathological staging. Bilateral biopsies were assessed in 25 patients to evaluate for any differences in histopathological staging of OSMF in the same mouth. Extent of clinician agreement for categorized staging data was evaluated using Cohen's weighted kappa analysis. Cross-tabulation was performed on categorical grading data to understand the intercorrelation, and the unweighted kappa analysis was used to assess the bilateral grade agreement. Probabilities of less than 0.05 were considered significant. Data were analyzed using SPSS Statistics (version 25.0, IBM, USA). RESULTS: A low agreement was found between all the stages depicting the independent nature of trismus, clinical features, and histopathological components (K = 0.312, 0.167, 0.152) in OSMF. Following analysis, a three-component classification scheme (TFM classification) was developed that describes the severity of each independently, grouping them using a novel three-tier staging scheme as a guide to the treatment plan. CONCLUSION: The proposed classification and staging could be useful for effective communication, categorization, and for recording data and prognosis, and for guiding treatment plans. Furthermore, the classification considers OSMF malignant transformation in detail.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1111/jop.12689

  5 / 1185 MEDLINE  
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[PMID]: 29496062
[Au] Autor:Nag R; Kumar Das R
[Ad] Address:Centre for Biomaterials, Cellular, and Molecular Theranostics, VIT University, Vellore 632014, India. Electronic address: reetoja.nag2016@vitstudent.ac.in.
[Ti] Title:Analysis of images for detection of oral epithelial dysplasia: A review.
[So] Source:Oral Oncol;78:8-15, 2018 Mar.
[Is] ISSN:1879-0593
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This paper provides a review of various image analysis approaches that have been previously used for recognition of dysplasia in images of the epithelium of the oral cavity. This domain has become especially admissible with the uncovering of the importance of image analysis which can probably be an aid to subjective diagnosis by histopathologists. Oral malignancy is a rampant form of cancer found among people of the Indian subcontinent due to various deleterious habits like consumption of tobacco, areca nut, betel leaf etc. Oral Submucous Fibrosis, a precancer, whose pathological category falls between normal epithelium and epithelial dysplasia, is caused because of these habits and can ultimately lead to oral cancer. Hence early detection of this condition is necessary. Image analysis methods for this purpose have an enormous potential which can also reduce the heavy workload of pathologists and to refine the criterion of interpretation. This paper starts with a critique of statistics of oral carcinoma in India and distribution of cancer in intra-oral sites and moves on to its causes and diagnostic approaches including causative agents, problems in curative approach and importance of image analysis in cancer detection. The various image analysis methods to appraise the cytological and architectural changes accompanied by Oral Epithelial Dysplasia in the images of the oral epithelial region have been described in relation to 2005 WHO Classification System and it was found that in future, analysis of images based on the mentioned methods has the potential in better interpretation and diagnosis of oral carcinoma.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review

  6 / 1185 MEDLINE  
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[PMID]: 29428570
[Au] Autor:Sarode SC; Panta P; Sarode GS; Gadbail AR; Gondivkar SM; Patil S
[Ad] Address:Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaramnagar, Pimpri, Pune - 18, Maharashtra, India. Electronic address: drsachinsarode@gmail.com.
[Ti] Title:New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment.
[So] Source:Oral Oncol;78:218-219, 2018 Mar.
[Is] ISSN:1879-0593
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review

  7 / 1185 MEDLINE  
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[PMID]: 29485009
[Au] Autor:Sharma M; Shetty SS; Radhakrishnan R
[Ad] Address:Department of Oral Pathology, ITS Dental College, Hospital and Research Center, Greater Noida - 201308. India.
[Ti] Title:Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation.
[So] Source:Recent Pat Anticancer Drug Discov;, 2018 Feb 26.
[Is] ISSN:2212-3970
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. OBJECTIVE: The objective of this article is to decipher the pathogenesis of oral submucous fibrosis in order to identify novel drug targets. METHOD: A thorough literature review based on oral submucous fibrosis being an overhealing wound was conducted; several related patents were identified and herewith reviewed. Necessary pathways were elaborated and deliberated in the manuscript in form of schemas, keeping our hypothesis in mind. Several novel molecular targets were identified and discussed in detail. RESULTS: Several patents demonstrating inhibition of fibrosis via chemokine ligand mimetics, anticonnexon antibodies, Stem cell therapy, Fibronectin blocking peptides, HIF inhibitors, recombinant erythropoietin, Xanthine Oxidase inhibitors, long non-coding RNAs, targeting inflammation, increasing TH-1/TH-2 cytokine ratio, t-box protein 4, Chromium containing compositions, Iron-based nanocomposites, Lactate Dehydrogenase-5 inhibitors, Carbonic Anhdrase-9 inhibitors, proton pump inhibitors, Liposomal encapsulated glutathione, Monocarboxylate-4 inhibitors, Autophagy Inhibitors, Submucosal anti-IL-6 antibodies, Fibrin Degradation Products for monitoring of malignancy and fibrosis, small molecule antagonists like Vorapaxar, Tiplaxtinin, and TM-5275, TGF-ß signalling inhibitors were identified as future therapeutic avenues. CONCLUSION: Considering, Oral submucous fibrosis as an overhealing wound explains both pathogenesis and malignant transformation. Certainly, abnormalities in coagulation and fibrinolytic system are a common denominator in the profibrotic milieu and associated malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.2174/1574892813666180227103147

  8 / 1185 MEDLINE  
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[PMID]: 29480603
[Au] Autor:Coletta RD; Salo T
[Ad] Address:Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
[Ti] Title:Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?
[So] Source:Oral Dis;24(1-2):84-88, 2018 Mar.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:In oral cancer, acquisition of α-smooth muscle actin (α-SMA)-positive fibroblasts, known as myofibroblasts or carcinoma-associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Process
[do] DOI:10.1111/odi.12694

  9 / 1185 MEDLINE  
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[PMID]: 29478271
[Au] Autor:Sarode SC; Chaudhary M; Gadbail A; Tekade S; Patil S; Sarode GS
[Ad] Address:Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram nagar, Pimpri, Pune, 411018, Maharashtra, India.
[Ti] Title:Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: a preliminary study.
[So] Source:J Oral Pathol Med;, 2018 Feb 25.
[Is] ISSN:1600-0714
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:BACKGROUND: The grading of oral epithelial dysplasia (OED) is not applicable to oral submucous fibrosis (OSMF) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected OSCC specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of OSMF patients with the mucosal margins of OSCC associated with OSMF (OSCC-OSMF). METHODS: We evaluated 17 dysplastic features in 37 patients with OSMF (biopsy site: buccal mucosa) and 37 patients with OSCC-OSMF (mucosal margins involving buccal mucosa) using histopathological staining. RESULTS: Dysplastic features, such as keratin pearls within rete ridges, nuclear pleomorphism, and atypical mitotic figures, were not observed in the epithelium of the OSMF or OSCC-OSMF groups. Basal cell hyperplasia (p=0.016), abnormal superficial mitosis (p=0.010), increased nuclear-cytoplasmic ratio (p=0.034), and hyperchromasia (p=0.031) were predominantly seen in the OSCC-OSMF group. We found no statistically significant differences in the following parameters: irregular epithelial stratification (p=1.00), loss of basal cell polarity (p=0.237), presence of drop-shaped rete ridges (p=0.077), increased number of mitotic figures (p=0.154), premature keratinization in single cells (p=0.499), anisonucleosis (p=0.289), anisocytosis (p=0.079), cellular pleomorphism (p=0.317), and increased number and size of nucleoli (p=0.129). CONCLUSION: Increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear-cytoplasmic ratio, and hyperchromasia are high-risk features for OSMF, and affected patients should be followed on a priority basis for the early detection of OSCC. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:Publisher
[do] DOI:10.1111/jop.12699

  10 / 1185 MEDLINE  
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[PMID]: 29223311
[Au] Autor:Agrawal D; Pathak R; Newaskar V; Idrees F; Waskle R
[Ad] Address:Reader, Department of Oral and Maxillofacial Surgery, Government College of Dentistry, Indore, India.
[Ti] Title:A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients.
[So] Source:J Oral Maxillofac Surg;76(3):676.e1-676.e5, 2018 Mar.
[Is] ISSN:1531-5053
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to compare the efficacy of locally available nasolabial and buccal fat pad flaps for increasing postoperative mouth opening in the reconstruction of the defect created after fiberotomy in surgically treated cases of oral submucous fibrosis (OSMF). MATERIALS AND METHODS: Of 32 patients selected for the study, 21 patients underwent closure of the surgical defect using the buccal fat pad (group 1) and 11 patients underwent closure of the surgical defect using a nasolabial flap (group 2). Histologically proven cases of OSMF with a mouth opening no larger than 25 mm were included in the study. Patients in groups 1 and 2 were evaluated at regular intervals and mouth opening was documented preoperatively, intraoperatively, and at 3 and 6 months of follow-up. The results were analyzed by paired and unpaired t tests. RESULTS: In groups 1 and 2, mouth opening differed substantially at all periods of follow-up from preoperative values. At 3-month follow-up, mean mouth opening increased to 32.41 mm in group 2 compared with 30.47 in group 1. No relevant difference was observed in mouth opening between groups 1 and 2 at the end of 6 months. The effective increase in mouth opening at the end of 6 months compared with the preoperative value was statistically different in group 2 (mean increase, 24.2 mm) compared with group 1 (mean increase, 19.2 mm). CONCLUSION: Nasolabial flaps are a good option for the coverage of surgically treated defects in OSMF compared with the buccal fat pad.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:In-Data-Review


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