Database : MEDLINE
Search on : Orchitis [Words]
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[PMID]: 29519910
[Au] Autor:Rockwood N; Nwokolo N
[Ad] Address:Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
[Ti] Title:Syphilis the great pretender: when is cancer not cancer?
[So] Source:Sex Transm Infect;, 2018 Mar 08.
[Is] ISSN:1472-3263
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The number of cases of syphilis continues to rise in the UK, USA and elsewhere and may present to a variety of clinical specialties. We report a complex case of early acquired disseminated syphilis causing an ulceronodular rash (lues maligna), orchitis, osteitis and lung nodules in an immunocompetent man who has sex with men who presented to the genitourinary medicine clinic. Syphilis should be considered in the differential diagnoses of multiple clinical presentations and optimal management should involve multidisciplinary care.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  2 / 2546 MEDLINE  
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[PMID]: 29516577
[Au] Autor:Li Y; Wang J; Yu L; Zhao K; Chen B; Li C; Yang F; Yuan H; Zhang H
[Ad] Address:Institute of Family Planning Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Title:Effects of prokineticin 2 on testicular inflammation in rats.
[So] Source:Am J Reprod Immunol;, 2018 Mar 08.
[Is] ISSN:1600-0897
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:PROBLEM: Prokineticin 2 (PK2), a pro-inflammatory peptide, is highly expressed in primary spermatocytes. However, systematic research on PK2 and testicular inflammation is lacking to date. METHOD OF STUDY: An experimental autoimmune orchitis (EAO) model was established to detect the expression of PK2 and its receptor (prokineticin receptor 1, PKR1) 50 and 80 days after immunization. PK2 siRNA sequence was injected into the rat rete testis to downregulate the expression of PK2. PK2 was over-expressed in the testis by injecting PK2 protein through the rat rete testis at different concentrations. Testicular morphology and expression of inducible nitric oxide synthase (iNOS) were detected after the intervention. RESULTS: Results showed that PK2 and PKR1 were upregulated in EAO at 50 days and downregulated at 80 days. PK2 over-expression contributed to the apoptosis of spermatogenic epithelial cells and increased infiltration of the inflammatory cells, whereas PK2 under-expression showed no change. Furthermore, iNOS expression was increased significantly when PK2 was over-expressed. CONCLUSION: This finding demonstrated that the PK2/PKR1 signals may have an essential role in the regulation of testicular inflammation through iNOS. PK2 interference may represent a novel and promising therapeutic strategy for the clinical management of orchitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1111/aji.12843

  3 / 2546 MEDLINE  
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[PMID]: 29487346
[Au] Autor:Lei T; Moos S; Klug J; Aslani F; Bhushan S; Wahle E; Fröhlich S; Meinhardt A; Fijak M
[Ad] Address:Department of Anatomy and Cell Biology, Justus-Liebig University, Giessen, Germany.
[Ti] Title:Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling.
[So] Source:Sci Rep;8(1):3741, 2018 Feb 27.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Galectin-1 (Gal-1) is a pleiotropic lectin involved in the modulation of immune responses. Using a model of rat experimental autoimmune orchitis (EAO), we investigated the role of Gal-1 in testicular inflammation. EAO is characterized by leukocytic infiltrates in the interstitium, damage of spermatogenesis and production of inflammatory mediators like TNFα and MCP1 causing infertility. In normal rat testis Gal-1 was mainly expressed in Sertoli cells and germ cells. In the inflamed testis, Gal-1 expression was significantly downregulated most likely due to germ cell loss. Analyses of lectin binding and expression of glucosaminyl- and sialyltransferases indicated that the glycan composition on the cell surface of Sertoli and peritubular cells becomes less favourable for Gal-1 binding under inflammatory conditions. In primary Sertoli cells Gal-1 expression was found to be upregulated after TNFα challenge. Pretreatment with Gal-1 synergistically and specifically enhanced TNFα-induced expression of MCP1, IL-1α, IL-6 and TNFα in Sertoli cells. Combined stimulation of Sertoli cells with Gal-1 and TNFα enhanced the phosphorylation of MAP kinases as compared to TNFα or Gal-1 alone. Taken together, our data show that Gal-1 modulates inflammatory responses in Sertoli cells by enhancing the pro-inflammatory activity of TNFα via stimulation of MAPK signalling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22135-w

  4 / 2546 MEDLINE  
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[PMID]: 29378173
[Au] Autor:Clancy CS; Van Wettere AJ; Siddharthan V; Morrey JD; Julander JG
[Ad] Address:Utah Veterinary Diagnostic Laboratory, School of Veterinary Medicine, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah. Electronic addre
[Ti] Title:Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and IFNAR Mice.
[So] Source:Am J Pathol;, 2018 Jan 31.
[Is] ISSN:1525-2191
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:An understanding of the pathogenesis of infection with the Zika virus in the male reproductive tract is vital for the development of vaccines and antivirals that will limit or prevent sexual transmission. Two common immunocompromised mouse strains used in transmission studies-male with genes encoding interferon-α receptors 1 and 2 (IFNAR; AG129) and with IFN-α receptor gene knockout (IFNAR )-were infected with a Puerto Rican Zika virus isolate (PRVABC59), and pathology was assessed 5 to 11 days after infection. Virus was detected by immunohistochemistry and quantitative RT-PCR in the testicle and epididymis of AG129 and IFNAR mice, and by immunohistochemistry in the prostate and seminal vesicle of infected AG129 mice. Severe disease manifestations initiating as epididymitis and progressing to orchitis were observed in both models, with more severe inflammation noted in the AG129 mouse strain. Significant inflammation was not observed in any evaluated accessory sex gland at any point during infection. Time-course analysis of infection revealed an increase in the severity of disease within the epididymis of both strains, indicating a potential route of sexual transmission. Male mice with IFNAR1 may better recapitulate Zika virus in humans and provide insight into the mechanism of sexual transmission, due to milder histopathologic lesions, the presence of histologically normal sperm in epididymal tubules, and an ability to survive the acute phase of disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher

  5 / 2546 MEDLINE  
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[PMID]: 29460046
[Au] Autor:Bertolotto M; Muça M; Currò F; Bucci S; Rocher L; Cova MA
[Ad] Address:Department of Radiology, University of Trieste, Ospedale di Cattinara, Strada di Fiume 447, 34149, Trieste, Italy. bertolot@units.it.
[Ti] Title:Multiparametric US for scrotal diseases.
[So] Source:Abdom Radiol (NY);, 2018 Feb 19.
[Is] ISSN:2366-0058
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Multiparametric US is increasingly recognized as a valuable problem-solving technique in scrotal pathologies. Compared to conventional Doppler modes, contrast-enhanced ultrasonography (CEUS) has higher sensitivity in assessing the presence or absence of flows, and to improve differentiation between poorly vascularized tumors and non-neoplastic, avascular lesions. Characterization of benign and malignant complex cysts is improved. In trauma patients, CEUS can help evaluating the viability of testicular parenchyma. In patients with severe epididymo-orchitis, it allows unequivocal assessment of post-inflammatory ischemic changes and abscess formation. CEUS does not add significantly to conventional Doppler modes in spermatic cord torsion. Attempt of differentiating benign and malignant tumors remains a research tool. In the clinical practice, elastography has a limited role for tumor characterization. The majority of malignant tumors are stiff at elastography, but they may display soft areas, or appear globally soft. A quantitative evaluation of testicular stiffness is feasible using shear-wave elastography. Potential clinical applications for elastographic modes could include work-up of infertile patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1007/s00261-018-1510-7

  6 / 2546 MEDLINE  
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[PMID]: 29456227
[Au] Autor:Selmi Y; Kheder-Elfekih R; Jebali H; Fatma LB; Smaoui W; Krid M; Beji S; Rais L; Zouaghi MK
[Ad] Address:Department of Nephrology, La Rabta Hospital, Jebbari, Tunis, Tunisia.
[Ti] Title:A case of renal granulomatosis with polyangiitis following intravesical bacillus Calmette-Guérin therapy.
[So] Source:Saudi J Kidney Dis Transpl;29(1):185-188, 2018 Jan-Feb.
[Is] ISSN:1319-2442
[Cp] Country of publication:Saudi Arabia
[La] Language:eng
[Ab] Abstract:Various adverse reactions may occur after intravesical bacillus Calmette-Guérin (BCG) therapy. Although the virulence of attenuated BCG is low, serious complications such as bacterial cystitis, bladder contractures, granulomatous prostatitis, epididymitis, orchitis, and systemic reactions such as fever and malaise have been described. Disseminated granulomatosis such as hepatitis and pneumonitis have also been described, but are rare. We report here the case of a 67-year-old patient who presented with renal granulomatosis with polyangiitis following intravesical BCG therapy for superficial bladder tumor. The biological evaluation revealed the presence of perinuclear anti-neutrophil cytoplasmic antibodies with specificity for antimyeloperoxidase. Renal biopsy specimen revealed pauci-immune crescentic glomerulonephritis with segmental glomerular necrosis, presence of granulomas and no evidence of any caseating necrosis. He received antituberculosis drugs in addition to corticosteroids and cyclophosphamide without any improvement of the renal function.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:In-Data-Review
[do] DOI:10.4103/1319-2442.225178

  7 / 2546 MEDLINE  
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[PMID]: 29450767
[Au] Autor:Ryan L; Daly P; Cullen I; Doyle M
[Ad] Address:Department of Clinical Microbiology, University Hospital Waterford, Waterford, Ireland. ryanlaurab@gmail.com.
[Ti] Title:Epididymo-orchitis caused by enteric organisms in men > 35 years old: beyond fluoroquinolones.
[So] Source:Eur J Clin Microbiol Infect Dis;, 2018 Feb 15.
[Is] ISSN:1435-4373
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Epididymo-orchitis is a common urological condition in men of all ages, causing a unilateral or bilateral swelling of the epididymis and/or testis. It is frequently caused by sexually transmitted infections, Chlamydia trachomatis and Neisseria gonorrheae, as well as common enteric organisms implicated in urinary tract infections. Men over 35 years old may develop epididymo-orchitis associated with enteric organisms, often associated with functional bladder outlet problems such as benign prostatic hyperplasia or urethral stricture disease. Fluoroquinolones, especially ciprofloxacin, have long been the mainstay of treatment for these infections; however, rising resistance to ciprofloxacin in E. coli isolates in Europe and the USA means that there is an unprecedented necessity for alternative antimicrobials with adequate penetration into genital tissues (epididymis and testes) to allow appropriate and comprehensive treatment of epididymo-orchitis in this group of patients.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1007/s10096-018-3212-z

  8 / 2546 MEDLINE  
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[PMID]: 29428190
[Au] Autor:Boehm A; Bruyère F
[Ad] Address:Service d'urologie, CHRU de Tours, université François-Rabelais, 37000 Tours, France. Electronic address: axelleboehm@gmail.com.
[Ti] Title:Dermato-urologie : les lésions des organes génitaux externes de l'homme à connaître par l'urologue. [Dermato-urology: Male genital lesions urologist should know].
[So] Source:Prog Urol;, 2018 Feb 07.
[Is] ISSN:1166-7087
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:This article aimed to gather male genital dermatoses that may lead to consult a urologist, except pre-neoplastic or neoplastic lesion. METHOD: This review is based on a research on Pubmed and EM-consult database, in English and in French, using the following key terms "male genital dermatoses", "male genital lesions", "balanitis", "balanoposthitis", "dermatoses des organes génitaux externes masculines", "lésions des organes génitaux externes de l'homme", "balanoposthites". RESULTS: It highlights normal morphological aspects, acute balanoposthitis (nonspecific, infectious, allergic, irritative and traumatic), common skin disease localized to male genital and male genital specific dermatoses. CONCLUSION: Any suspicious, fixed, must lead to a skin biopsy.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180211
[Lr] Last revision date:180211
[St] Status:Publisher

  9 / 2546 MEDLINE  
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[PMID]: 29415866
[Au] Autor:Gavrel M; Benabida S; Ferlicot S; Bellin MF; Rocher L
[Ad] Address:Department of diagnostic & interventional radiology, hôpitaux Paris Sud, Site Bicêtre, 78, avenue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
[Ti] Title:Idiopathic granulomatous orchitis: Ultrasound and MR imaging features.
[So] Source:Diagn Interv Imaging;, 2018 Feb 04.
[Is] ISSN:2211-5684
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher

  10 / 2546 MEDLINE  
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[PMID]: 29340471
[Au] Autor:Botero-García CA; Faccini-Martínez ÁA; Uribe E; Calixto OJ; Pérez-Díaz CE; Osejo-Diago PP; Franco-Maz PG
[Ad] Address:Grupo de Investigación en Enfermedades Infecciosas Hospital Militar Central "GREINMIL", Bogotá, Colombia.
[Ti] Title:Epididymo-orchitis caused by Histoplasma capsulatumin a Colombian patient.
[So] Source:Rev Soc Bras Med Trop;50(6):868-870, 2017 Nov-Dec.
[Is] ISSN:1678-9849
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Although histoplasmosis is generally a self-limited disease, disseminated infection can occur in patients lacking effective cell-mediated immunity, reaching virtually every organ, even the genitourinary tract in rare cases. We report a case of epididymo-orchitis in an immunocompetent 38-year-old bricklayer from the rural area of Villeta, Cundinamarca, Colombia. The patient presented with testicular pain and macroscopic scrotal changes requiring a left orchiectomy, with microbiological isolation and molecular confirmation of Histoplasma capsulatum.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:In-Process


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