Database : MEDLINE
Search on : Osteolysis [Words]
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[PMID]: 29515110
[Au] Autor:Wang Q; Mo J; Zhao C; Huang K; Feng M; He W; Wang J; Chen S; Xie Z; Ma J; Fan S
[Ad] Address:Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, 3# East Qingchun Road, Hangzhou, Zhejiang Province, 310016, China.
[Ti] Title:Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells.
[So] Source:Cell Death Dis;9(3):376, 2018 Mar 07.
[Is] ISSN:2041-4889
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast cancer-induced osteolysis and elucidated the possible mechanisms involved in this process. We first verified that RA could suppress osteoclast formation and bone resorption in vitro. Next, we confirmed that RA suppressed Ti-particle-induced osteolysis in a mouse calvarial model, possibly through inhibition of the SRC/AKT signaling pathway. A breast cancer-induced osteolysis mouse model further revealed the positive protective effects of RA by micro-computed tomography and histology. Finally, we demonstrated that RA inhibited invasion and AKT/mammalian target of rapamycin signaling and induced apoptosis in MDA-MB-231 cells. These results indicate that RA is an effective inhibitor of breast cancer-induced osteolysis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1038/s41419-018-0417-0

  2 / 10701 MEDLINE  
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[PMID]: 29441913
[Ti] Title:Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: evidence and .
[So] Source:Pharmazie;71(7):382-389, 2016 Jul 07.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The occurrence of bone defects can be due to a variety of factors not limited to bone fractures and tumours. Most diseased bone is removed and the patient fitted with prosthetics, prior to use of certain factors such as bone morphogenetic proteins (BMPs) to aid healing. Recently, the protein pigment epithelium-derived factor (PEDF) and the polysaccharide chitosan have been found to have promising effects on the regeneration of bone, with the major advantage of these agents being their safety to date. A study was performed to determine whether the combination of both chitosan and PEDF would enhance greater bone regeneration effects. Post-formulation, in silico tests (particle sizing and surface charge determination) were followed by several cell-based assays (microparticle cellular uptake, cytotoxicity, mitochondrial abundance, bone mineral formation, colony formation in matrigel, and colony formation in collagen I matrix), and finally in vivo testing where microparticles were injected periosteally in the hindlimb. Collectively, these findings support the idea that PEDF microencapsulated within chitosan promotes bone regeneration, and has potential for bone trauma management. Future studies will examine the ability of this promising bone regeneration microparticle to heal bone in disease states such as fracture and tumour-mediated osteolysis.
[Mh] MeSH terms primary: Bone Regeneration/drug effects
Eye Proteins/pharmacology
Nerve Growth Factors/pharmacology
Serpins/pharmacology
[Mh] MeSH terms secundary: Animals
Bone Density/drug effects
Capsules
Cell Survival/drug effects
Chitosan/pharmacology
Collagen Type I/pharmacology
Colony-Forming Units Assay
Computer Simulation
Drug Compounding
Eye Proteins/administration & dosage
Eye Proteins/metabolism
Hindlimb
Humans
Injections
Male
Mice
Mice, Inbred BALB C
Mitochondria/drug effects
Nerve Growth Factors/administration & dosage
Nerve Growth Factors/metabolism
Particle Size
Serpins/administration & dosage
Serpins/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Capsules); 0 (Collagen Type I); 0 (Eye Proteins); 0 (Nerve Growth Factors); 0 (Serpins); 0 (pigment epithelium-derived factor); 9012-76-4 (Chitosan)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6010

  3 / 10701 MEDLINE  
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[PMID]: 29516107
[Au] Autor:Patzer T
[Ad] Address:Orthopädie-Zentrum, Fachzentrum für Schulter, Ellenbogen, Knie und Sportorthopädie, Schön-Klinik Düsseldorf, Am Heerdter Krankenhaus 2, 40549, Düsseldorf, Deutschland. thipa@me.com.
[Ti] Title:Inverse Schultertotalendprothese bei Rotatorenmanschettendefektarthropathie. [Reversed total shoulder arthroplasty in rotator cuff defect arthropathy].
[So] Source:Orthopade;, 2018 Mar 07.
[Is] ISSN:1433-0431
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND: In a progredient rotator cuff tear with tendon retraction, fatty infiltration and atrophy of rotator cuff muscles the humerus cannot be centered and stabilized sufficiently in the glenohumeral joint. This leads to rotator cuff defect arthropathy as an eccentric osteoarthritis with acetabularization and wear of the acromion, as well as of the glenoid. INDICATION: A painful pseudoparalysis of the shoulder indicates the implantation of a reversed total shoulder arthroplasty (rTSA) to reduce pain and restore active motion. The rTSA improves the motoric function of the deltoid muscle by medialization and caudalization of the center of rotation via an optimized lever arm and is also indicated in cranio-caudally centered osteoarthritis with static posterior humeral decentration due to a bi-concavely eroded glenoid. THERAPY: Currently, humeral anatomical resection with an inclination of 135° and a humeral retrotorsion of 20-40°, in rTSA in contrast to 155° inclination, has been shown to lead to better glenohumeral motion without loss of stability. Additionally, a reduced glenohumeral offset should be restored by especially bony lateral augmentation of the glenoid. In a pre-operatively positive lag sign for external rotation caused by a rupture of the infraspinatus/teres minor tendon, a lateral latissimus/teres major muscle tendon transfer in rTSA can optimize active external rotation. The tendon of the subscapularis muscle should be re-fixated in the deltopectoral approach for rTSA whenever possible for better anterior stability of the glenohumeral joint. Larger diameters of the glenospheres have been shown to have more stability and better motion. Humeral metaphyseal metal liners with corresponding polyethylene glenospheres can avoid osteolysis of the inferior scapular neck caused by polyethylene debris due to impingement of the humeral liner at the scapular neck.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1007/s00132-018-3543-6

  4 / 10701 MEDLINE  
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[PMID]: 29512804
[Au] Autor:Zehani A; Chelly I; Marrakchi J; Chouat E; Besbes G; Haouet S; Kchir N
[Ti] Title:Malignant transformation of nasal inverted papilloma into sarcomatoid carcinoma.
[So] Source:Tunis Med;95(6):453-454, 2017 Jun.
[Is] ISSN:0041-4131
[Cp] Country of publication:Tunisia
[La] Language:eng
[Ab] Abstract:A 57 year-old, male presented with a chronic unilateral nasal obstruction and epistaxis. Intranasal endoscopy showed multiple polypoid lesions. The computed tomography exam revealed a heterogeneous mass that occupied the right nasal cavity with osteolysis of the middle and lower cone causing fluid retention of the right maxillary sinus. He underwent resection of these lesions. Pathological examination revealed malignant transformation of nasal inverted papilloma into sarcomatoid carcinoma. This case report highlights the importance of considering malignant transformation in the differential diagnosis of polypoid lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  5 / 10701 MEDLINE  
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[PMID]: 29512770
[Au] Autor:Zheng X; Kang W; Liu H; Guo S
[Ad] Address:Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
[Ti] Title:Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway.
[So] Source:Int J Mol Med;, 2018 Feb 27.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process of breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertaken to explore the inhibition effects of total flavonoids from Scutellaria barbata D. Don (TF-SB) on human breast carcinoma bone metastasis. MDA-MB-231 cells and nude mouse models of breast cancer bone metastasis were given TF-SB in different concentrations. The proliferation, migration and invasion potentials of MDA-MB-231 cells were respectively tested. The effects of TF-SB on tumor weights and bone destruction were investigated. The mRNA and protein expression of PTHrP, OPG and RANKL were assessed by qPCR and western blot analysis. In vitro, TF-SB inhibited the proliferation, migration and invasion of MDA-MB-231 cells in a dose-dependent manner. In vivo, TF-SB prevented bone metastasis of breast cancer by decreasing the number of osteoclast cells per field in a dose-dependent manner, but not affecting tumor growth or mouse survival. Molecular analysis revealed that TF-SB controled the secretion of osteolysis-related factors PTHrP and its downstream RANKL/OPG. Together, by controlling the expression of PTHrP and its downstream OPG/RANKL, TF-SB has significant inhibition effects on breast cancer bone metastasis, which indicates a new therapeutic method.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.3892/ijmm.2018.3515

  6 / 10701 MEDLINE  
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[PMID]: 29512766
[Au] Autor:Luo G; Li F; Li X; Wang ZG; Zhang B
[Ad] Address:State Key Laboratory of Trauma, Burns and Combined Injury, Department 4, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, P.R. China.
[Ti] Title:TNF­α and RANKL promote osteoclastogenesis by upregulating RANK via the NF­κB pathway.
[So] Source:Mol Med Rep;, 2018 Mar 07.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Although tumor necrosis factor alpha (TNF­α) is known to serve a critical role in the pathogenesis of inflammatory osteolysis, the exact mechanisms underlying the effects of TNF­α on osteoclast recruitment and differentiation remain unclear. To investigate the mechanisms by which TNF­α influences osteoclast differentiation, mouse bone marrow­derived macrophages (BMMs) were used as osteoclast precursors, and osteoclastogenesis was induced by macrophage colony­stimulating factor and receptor activator of nuclear factor (NF)­κB ligand (RANKL) with or without TNF­α for 4 days. Then, NF­κB was inhibited using the inhibitor, BAY 11­7082. The results indicated that treatment with TNF­α alone did not induce osteoclastogenesis of BMMs. However, TNF­α in combination with RANKL dramatically stimulated the differentiation of osteoclasts and positively regulated the expression of mRNA markers of osteoclasts. Finally, treatment of BMMs with BAY 11­7082 prevented the formation of mature osteoclasts by BMMs treated with TNF­α only or with RANKL, as well as the upregulation of osteoclast marker genes. Therefore, although TNF­α does not induce osteoclastogenesis alone, it does work with RANKL to induce osteoclastic differentiation, and the NF­κB pathway may serve an important role in this process.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.3892/mmr.2018.8698

  7 / 10701 MEDLINE  
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[PMID]: 29510952
[Au] Autor:Kleeman LT; Bala A; Penrose CT; Seyler TM; Wellman SS; Bolognesi MP
[Ad] Address:Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.
[Ti] Title:Comparison of Postoperative Complications Following Metal-on-Metal Total Hip Arthroplasty With Other Hip Bearings in Medicare Population.
[So] Source:J Arthroplasty;, 2018 Feb 05.
[Is] ISSN:1532-8406
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The use of metal-on-metal (MoM) hip bearings has declined in the recent years due to strong evidence of their high complication rates and early failure. Hip implants with highly cross-linked polyethylene liners and ceramic bearings have become the modern implants of choice. We sought to determine if MoM implants are associated with higher complication and revision rates when compared to other hip bearings in the Medicare population. METHODS: We retrospectively reviewed a Medicare database (2005-2011) for patients who underwent a primary total hip arthroplasty with a MoM, metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), or ceramic-on-ceramic (CoC) implant (minimum 2 years of follow-up). Patient comorbidities and medical/surgical complication rates were analyzed at various time points postoperatively. RESULTS: We identified 288,118 patients, including 81,520 patients with a MoM implant, 162,881 with MoP, 33,819 with CoP, and 9898 with CoC implant. Surgical complication rates were higher for MoM implants including infection, osteolysis/polywear, mechanical complications, and need for hip irrigation and debridement. Overall revision rates were significantly higher for MoM implants (5.28%) compared to MoP (4.28%, odds ratio [OR] 1.26, P < .001) and CoP (3.52%, OR 1.55, P < .001) but only by one to two percent. MoM revision rates were similar to CoC implants (4.94%, OR 1.00, P = .096). CONCLUSIONS: MoM implants were associated with higher revision rates (5.28%) compared to MoP (4.28%) and CoP (3.52%) implants in the Medicare population. Both complication and revision rates were comparable to CoC implants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher

  8 / 10701 MEDLINE  
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[PMID]: 29510473
[Au] Autor:Tsuka T; Okamoto Y; Yamamoto N; Hayashi K; Morita T; Sunden Y; Murahata Y; Azuma K; Osaki T; Ito N; Imagawa T
[Ad] Address:Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, Tottori University, 4-101, Koyama-Minami, Tottori, Tottori, 680-8553, Japan.
[Ti] Title:Unilateral rostral mandibulectomy for gingival vascular hamartoma in two calves.
[So] Source:J Vet Sci;, 2018 Mar 06.
[Is] ISSN:1976-555X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:A 2-month-old female Holstein calf and a 5-month-old female Japanese black calf presented with a gingival vascular hamartoma located in the interdental space between the second and third mandibular incisors in the right and left mandibles, respectively. Osteolytic changes appeared within the mandibular bones adjacent to the masses on radiographic or computed tomographic images. The masses were removed along with affected mandibular bone by unilateral rostral mandibulectomy. Two cases exhibited a normal appetite and grew normally, with no cosmetic changes and recurrences. Unilateral rostral mandibulectomy should be applied for invasive gingival vascular hamartomas associated with osteolytic changes.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  9 / 10701 MEDLINE  
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[PMID]: 29252185
[Au] Autor:Gao X; Ge J; Li W; Zhou W; Xu L
[Ad] Address:Department of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221002, Jiangsu, China.
[Ti] Title:LncRNA KCNQ1OT1 ameliorates particle-induced osteolysis through inducing macrophage polarization by inhibiting miR-21a-5p.
[So] Source:Biol Chem;399(4):375-386, 2018 Mar 28.
[Is] ISSN:1437-4315
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:This study aimed to investigate the mechanism of lncRNA-KCNQ1OT1 on macrophage polarization to ameliorate particle-induced osteolysis. We used polymethylmethacrylate (PMMA) to induce primary bone marrow-derived macrophages (BMMs) obtained from mice and the RAW264.7 cell line, and found that the tumor necrosis factor-alpha (TNF-α) concentration and inducible nitric oxide synthase (iNOS) expression was increased, while interleukin (IL)-10 concentration and Arg1 expression were decreased in PMMA-induced cells. KCNQ1OT1 and IL-10 expression were both suppressed and miR-21a-5p expression was promoted in PMMA-induced cells. Overexpression of KCNQ1OT1 reversed the effect of PMMA on RAW264.7 cells, such as the reduced TNF-α concentration and iNOS expression, and increased IL-10 concentration and Arg1 expression in PMMA-induced cell transfected with pcDNA-KCNQ1OT1. The luciferase assay confirmed that IL-10 is a target of miR-21a-5p. RNA immunoprecipitation (RIP) and RNA pull-down experiments demonstrated that KCNQ1OT1 functions as a miR-21a-5p decoy. Thus, lncRNA KCNQ1OT1 induces M2 macrophage polarization to ameliorate particle-induced osteolysis by inhibiting miR-21a-5p.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review

  10 / 10701 MEDLINE  
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[PMID]: 27776448
[Au] Autor:Ye C; Zhang W; Jiang S; Yu Y; Zhou X; Zhu L; Xue D; He R
[Ad] Address:a Department of Orthopedic Surgery , the Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
[Ti] Title:Platelet-derived growth factor-BB attenuates titanium-particle-induced osteolysis in vivo.
[So] Source:Growth Factors;34(5-6):177-186, 2016 12.
[Is] ISSN:1029-2292
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Inflammation and osteoclastogenesis play critical roles in wear-particle-induced periprosthetic osteolysis (WPO). Platelet-derived growth factor-BB (PDGF-BB) could promote osteogenesis and inhibit inflammatory response. The aim of this study was to investigate the impact of PDGF-BB on WPO. Mice were divided into four groups, namely, sham, vehicle, low-, and high-dose PDGF-BB groups. Mice in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/day. Mice in the sham and vehicle groups received PBS daily. Two weeks after surgery, calvariae were harvested. Immunohistochemical analysis and µ-CT showed that PDGF-BB significantly reduced osteoclast formation and bone resorption. ELISA showed that rhPDGF-BB decreased the secretion of TNF-α, IL-1ß, and IL-6. Western blotting revealed that rhPDGF-BB stimulated the expression of osteocalcin and osteoprotegerin. Furthermore, more VEGF and CD31 proteins were observed due to PDGF-BB by immunofluorescence. In conclusion, these findings suggest that rhPDGF-BB represents a potential treatment for WPO.
[Mh] MeSH terms primary: Bone-Implant Interface/pathology
Osteolysis/drug therapy
Proto-Oncogene Proteins c-sis/therapeutic use
Titanium/adverse effects
[Mh] MeSH terms secundary: Animals
Interleukin-1beta/genetics
Interleukin-1beta/metabolism
Interleukin-6/genetics
Interleukin-6/metabolism
Mice
Mice, Inbred C57BL
Osteolysis/etiology
Platelet Endothelial Cell Adhesion Molecule-1/genetics
Platelet Endothelial Cell Adhesion Molecule-1/metabolism
Proto-Oncogene Proteins c-sis/administration & dosage
Tumor Necrosis Factor-alpha/genetics
Tumor Necrosis Factor-alpha/metabolism
Vascular Endothelial Growth Factor A/genetics
Vascular Endothelial Growth Factor A/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Proto-Oncogene Proteins c-sis); 0 (Tumor Necrosis Factor-alpha); 0 (Vascular Endothelial Growth Factor A); 1B56C968OA (becaplermin); D1JT611TNE (Titanium)
[Em] Entry month:1801
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:161026
[St] Status:MEDLINE
[do] DOI:10.1080/08977194.2016.1240680


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