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[PMID]: 29363210
[Au] Autor:Chan WY; Hickey EE; Khazandi M; Page SW; Trott DJ; Hill PB
[Ad] Address:Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, 5371, Australia.
[Ti] Title:In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa.
[So] Source:Vet Dermatol;29(2):149-e57, 2018 Apr.
[Is] ISSN:1365-3164
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Re-purposing of old drugs that are not used in human medicine is one approach that addresses the emergence of multidrug resistance in canine skin and ear infections, and can reduce the use of critically important human antibiotic classes. HYPOTHESIS/OBJECTIVES: To determine the antimicrobial activity of narasin, a polyether ionophore conventionally used as a rumen modifier and anticoccidial agent in production animals, against common clinical isolates of canine otitis externa (OE). ANIMALS/ISOLATES: Clinical isolates (n = 110) from canine OE were tested, including 17 meticillin-susceptible Staphylococcus pseudintermedius (MSSP), 13 multidrug-resistant Staphylococcus pseudintermedius (MDRSP), and 20 each of ß-haemolytic Streptococcus spp., Pseudomonas aeruginosa, Proteus mirabilis and Malassezia pachydermatis. METHODS: Bacterial and yeast isolates were subcultured, suspended in broth and inoculated into 96-well plates. Organisms were tested against concentrations of narasin ranging from 0.03 to 128 µg/mL. Minimal inhibitory concentrations (MICs) were determined after overnight incubation. RESULTS: Narasin MICs for staphylococcal and streptococcal isolates ranged from 0.06 to 0.25 µg/mL; MIC and MIC values for both organisms were 0.125 µg/mL. No MICs were achieved for Pseudomonas or Proteus isolates. There was a weak antifungal effect against M. pachydermatis isolates (MIC 32 to >128 µg/mL). CONCLUSIONS AND CLINICAL RELEVANCE: Narasin was effective against Gram-positive bacteria and had antifungal activity at higher concentrations against M. pachydermatis. However, the lack of Gram-negative activity would prevent its use as a sole antimicrobial agent in cases of canine OE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1111/vde.12516

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[PMID]: 29309708
[Au] Autor:Morita T; Ohmi A; Kiwaki A; Ike K; Nagata K
[Ad] Address:Department of Veterinary Pathobiology, Nippon Veterinary and Life Science University, Tokyo, Japan.
[Ti] Title:A New Stubby Species of Demodectic Mite (Acari: Demodicidae) From the Domestic Dog (Canidae).
[So] Source:J Med Entomol;55(2):323-328, 2018 Feb 28.
[Is] ISSN:1938-2928
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new species of Demodex was detected in the earwax of a dog with otitis externa in Saitama Prefecture, Japan, in July 2010. The opisthosoma length of the mite was slightly shorter than 1/2 of its body length, which was different from the other species in domestic dogs, D. canis and D. injai, but was similar to the form of mites termed "short-bodied species", including D. cornei. However, the stubby external form was morphologically different from those of "short-bodied species", excluding a case without a species description reported from Greece. Among known species, the mite was similar to D. equi and D. acutipes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review
[do] DOI:10.1093/jme/tjx226

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[PMID]: 29488502
[Au] Autor:Krasnozhen VN; Pokrovskaya EM; Bayazitova LT
[Ad] Address:Russian Medical Academy of Continuous Post-Graduate Education, Ministry of Health of the Russian Federation, Kazan, Russia, 420012.
[Ti] Title:Vidovoi sostav i chuvstvitel'nost' vozbuditelei naruzhnogo otita k komponentam preparata Polideksa. [The species composition and sensitivity of pathogenic microflora responsible for the development of otitis externa diffusa to the components of Polidexa].
[So] Source:Vestn Otorinolaringol;83(1):65-67, 2018.
[Is] ISSN:0042-4668
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The objective of the present work was to study microflora of the external auditory meatus in the patients presenting with bacterial otitis externa diffusa. The authors have analyzed the results of microbiological investigations involving 102 patients with this condition undergoing the treatment with 'Polidexa'. The characteristic of species composition of microflora associated with otitis externa diffusa is presented. The sensitivity of the most common pathogens responsible for the development of this pathology towards antibiotics contained in ear drops has been analysed. The advantages of the use Polidexa for the treatment of this acute ear disease are described.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review
[do] DOI:10.17116/otorino201883165-67

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[PMID]: 29466046
[Au] Autor:Ehling S; Baynes RE; Bäumer W
[Ti] Title:Impact of synthetic canine cerumen on in vitro penetration of auricular skin of dogs by florfenicol, terbinafine, and betamethasone acetate.
[So] Source:Am J Vet Res;79(3):333-341, 2018 Mar.
[Is] ISSN:1943-5681
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE To determine the pharmacokinetics of florfenicol, terbinafine, and betamethasone acetate after topical application to canine auricular skin and the influence of synthetic canine cerumen on pharmacokinetics. SAMPLE Auricular skin from 6 euthanized shelter dogs (3 females and 3 neutered males with no visible signs of otitis externa). PROCEDURES Skin adjacent to the external opening of the ear canal was collected and prepared for use in a 2-compartment flow-through diffusion cell system to evaluate penetration of an otic gel containing florfenicol, terbinafine, and betamethasone acetate over a 24-hour period. Radiolabeled C-terbinafine hydrochloride and H-betamethasone acetate were added to the gel to determine dermal penetration and distribution. Florfenicol absorption was determined by use of high-performance liquid chromatography-UV detection. Additionally, the effect of synthetic canine cerumen on the pharmacokinetics of all compounds was evaluated. RESULTS During the 24-hour experiment, mean ± SD percentage absorption without the presence of synthetic canine cerumen was 0.28 ± 0.09% for 3H-betamethasone acetate, 0.06 ± 0.06% for florfenicol, and 0.06 ± 0.02% for 14C-terbinafine hydrochloride. Absorption profiles revealed no impact of synthetic canine cerumen on skin absorption for all 3 active compounds in the gel or on skin distribution of H-betamethasone acetate and C-terbinafine hydrochloride. CONCLUSIONS AND CLINICAL RELEVANCE H-betamethasone acetate, C-terbinafine hydrochloride, and florfenicol were all absorbed in vitro through healthy auricular skin specimens within the first 24 hours after topical application. Synthetic canine cerumen had no impact on dermal absorption in vitro, but it may serve as a temporary reservoir that prolongs the release of topical drugs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Process
[do] DOI:10.2460/ajvr.79.3.333

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[PMID]: 29447882
[Au] Autor:Slengerik-Hansen J; Ovesen T
[Ad] Address:ENT-Department, Regional Hospital Holstebro, DK-7500, Holstebro, Denmark. Electronic address: jslengerik@gmail.com.
[Ti] Title:Acute external otitis as debut of acute myeloid leukemia - A case and review of the literature.
[So] Source:Int J Pediatr Otorhinolaryngol;106:110-112, 2018 Mar.
[Is] ISSN:1872-8464
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Acute leukemia is a well known childhood cancer. The relation between leukemia and otological symptoms has long been established but is highly rare as a debut symptom of leukemia. External otitis is a common condition affecting many children, and most cases are successively treated with topical medicine. Here we present a child with acute external otitis later shown to be the debut symptom of acute myeloid leukemia, to our knowledge the first specific case described. We have reviewed the literature to find red flags for suspicion of severe disease in case of acute external otitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:In-Process

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[PMID]: 29429416
[Au] Autor:Heward E; Cullen M; Hobson J
[Ad] Address:Department of Otolaryngology,University Hospital of South Manchester NHS Foundation Trust,UK.
[Ti] Title:Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance.
[So] Source:J Laryngol Otol;:1-4, 2018 Feb 12.
[Is] ISSN:1748-5460
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Otitis externa is a common presentation to secondary care otolaryngology clinics. Despite this, few studies have investigated the microbiology and antimicrobial resistance of otitis externa. This study aimed to examine these issues. METHODS: Analysis identified 302 swabs taken from 217 patients (100 male, 117 female), between 1 January 2015 and 30 March 2016, at our rapid access otolaryngology clinic. RESULTS: In total, 315 organisms were isolated; the most frequent was Pseudomonas aeruginosa (31.1 per cent), followed by candida species (22.9 per cent) and Staphylococcus aureus (11.7 per cent). P aeruginosa was sensitive to ciprofloxacin in 97.7 per cent of cases and to gentamicin in 78.4 per cent. CONCLUSION: Compared with studies worldwide, the relative proportions of different organisms causing otitis externa and the patterns of antimicrobial resistance differ. Increasing resistance of P aeruginosa to aminoglycosides demonstrates a changing pattern of antimicrobial resistance that has not been previously reported. Reassuringly, quinolone antibiotics remain highly effective when treating P aeruginosa.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1017/S0022215118000191

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[PMID]: 29381990
[Au] Autor:Zheng RW; Liu D; Eric TE; Ning YZ; Chen LL; Hu H; Ren Y
[Ad] Address:Department of Acupuncture and Moxibustion, Dongfang Hospital, The Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
[Ti] Title:A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis.
[So] Source:Medicine (Baltimore);96(47):e8833, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and is very easily misdiagnosed. PATIENT CONCERNS: A case of a 53-year-old male with Ramsay Hunt syndrome in conjunction with cranial polyneuritis is presented with early symptoms of vertigo, cephalalgia, and facial palsy, followed by zoster oticus 10 days later. DIAGNOSES: Diagnosis was challenging as this condition presents with multiple neuropathies, and attempting to diagnose based on clinical symptoms was often misleading. Polymerase chain reaction can be used to test for presence of the virus in the cerebrospinal fluid, followed by targeted drug therapy. INTERVENTIONS: Acupuncture, in conjunction with fire cupping, bloodletting around the afflicted region on the face, as well as oral consumption of herbal medicine and vitamins for nerve nourishment was given to treat this disease. OUTCOMES: Due to misdiagnosis resulting in delayed treatment, peripheral facial paralysis was left as the main sequelae, while other symptoms responded quickly to treatment. After a 6-month follow-up, facial palsy was still present. LESSONS: Considering that targeted antiviral therapy can be used to increase the effectiveness of treatment, early diagnosis, and timely use of medication is critical.
[Mh] MeSH terms primary: Cranial Nerve Diseases/diagnosis
Diagnostic Errors/adverse effects
Herpes Zoster Oticus/diagnosis
Neuritis/diagnosis
[Mh] MeSH terms secundary: Antiviral Agents/therapeutic use
Cranial Nerve Diseases/virology
Facial Paralysis/diagnosis
Facial Paralysis/virology
Headache/diagnosis
Headache/virology
Herpes Zoster Oticus/virology
Humans
Male
Middle Aged
Neuritis/virology
Vertigo/diagnosis
Vertigo/virology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antiviral Agents)
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008833

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[PMID]: 28468213
[Au] Autor:Tansuker HD; Eroglu S; Yenigün A; Taskin Ü; Oktay MF
[Ad] Address:*Department of Otorhinolaryngology and Head Neck Surgery, Bagcilar Training and Research Hospital †Department of Otorhinolaryngology and Head Neck Surgery, Bezmiâlem University Faculty of Medicine, Istanbul, Turkey.
[Ti] Title:Can Serum Neutrophil-to-Lymphocyte Ratio Be a Predictive Biomarker to Help Differentiate Active Chronic Otitis Media From Inactive Chronic Otitis Media?
[So] Source:J Craniofac Surg;28(3):e260-e263, 2017 May.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The authors' aim was to investigate whether serum neutrophil to lymphocyte ratio might be used as a predictive biomarker to help differentiate active from inactive chronic otitis media (COM). METHODS: Two hundred fifty-nine patients having inactive COM received tympanoplasty without mastoidectomy and were identified as Group 1. On the other hand, 254 patients having active COM received tympanoplasty with mastoidectomy and were identified as Group 2. Routine hemogram tests were performed preoperatively for both the groups. By performing a chart review, white blood cell count, red blood cell count, hemoglobin, hematocrit, platelet, and mean platelet volume values were compared between the groups in an age-matched and sex-matched manner. RESULTS: A total of 513 COM patients with age range of 7 to 65 years were included in the study. Two hundred seventy-five patients (53.6%) were male, 238 were (46.4%) female. Preoperatively both serum neutrophil and lymphocyte counts were significantly higher in Group 2 (P = 0.015 and P = 0.004, respectively). However, the neutrophil-to-lymphocyte ratios between the groups were not significantly different (P = 0.511). CONCLUSION: No statistically significant differences were identified from preoperative neutrophil-to-lymphocyte ratios between patients having active COM and inactive COM. LEVEL OF EVIDENCE: Level NA.
[Mh] MeSH terms primary: Lymphocytes/metabolism
Neutrophils/metabolism
Otitis Media/diagnosis
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Biomarkers/blood
Child
Chronic Disease
Diagnosis, Differential
Female
Humans
Lymphocyte Count
Male
Mastoidectomy
Middle Aged
Otitis Media/blood
Otitis Media/immunology
Otitis Media/surgery
Retrospective Studies
Treatment Outcome
Tympanoplasty
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers)
[Em] Entry month:1802
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[Js] Journal subset:D
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003484

  9 / 5044 MEDLINE  
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[PMID]: 29292129
[Au] Autor:Kviatkovski I; Shushan S; Oron Y; Frumin I; Amir D; Secundo L; Livne E; Weissbrod A; Sobel N; Helman Y
[Ad] Address:Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
[Ti] Title:Smelling Pseudomonas aeruginosa infections using a whole-cell biosensor - An alternative for the gold-standard culturing assay.
[So] Source:J Biotechnol;267:45-49, 2018 Feb 10.
[Is] ISSN:1873-4863
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Improved easy-to-use diagnostic tools for infections are in strong demand worldwide. Yet, despite dramatic advances in diagnostic technologies, the gold-standard remains culturing. Here we offer an alternative tool demonstrating that a bacterial biosensor can efficiently detect Pseudomonas aeruginosa infections in patients suffering from otitis externa. Detection was based on specific binding between the biosensor and 2-aminoacetophenone (2-AA), a volatile produced by P. aeruginosa in high amounts. We collected pus samples from ears of 26 subjects exhibiting symptoms of otitis externa. Detection of P. aeruginosa using the biosensor was compared to detection using gold-standard culturing assay and to gas-chromatograph-mass-spectrometry (GC-MS) analyses of 2-AA. The biosensor strain test matched the culture assay in 24 samples (92%) and the GC-MS analyses in 25 samples (96%). With this result in hand, we designed a device containing a whole-cell luminescent biosensor combined with a photo-multiplier tube. This device allowed detection of 2-AA at levels as low as 2 nmol, on par with detection level of GC-MS. The results of the described study demonstrate that the volatile 2-AA serves as an effective biomarker for P. aeruginosa in ear infections, and that activation of the biosensor strain by 2-AA provides a unique opportunity to design an easy-to-use device that can specifically detect P. aeruginosa infections.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[St] Status:In-Process

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[PMID]: 29360092
[Au] Autor:Sharma S; Corrah T; Singh A
[Ad] Address:Department of Ear, Nose and Throat, Northwick Park Hospital, London, United Kingdom.
[Ti] Title:Management of Necrotizing Otitis Externa: Our Experience with Forty-Three Patients.
[So] Source:J Int Adv Otol;13(3):394-398, 2017 Dec.
[Is] ISSN:1308-7649
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the impact of the introduction of a dedicated management protocol of necrotizing otitis externa patients with joint care between otorhinolaryngology and infectious diseases. MATERIALS AND METHODS: Retrospective review of case notes and the otorhinolaryngology department database of all adults admitted with necrotizing otitis externa at our teaching hospital over a 5-year period. The patients were split into two groups (first group of 10 patients prior to the introduction of the dedicated management protocol, and a second group of 33 patients managed after the introduction of this protocol). RESULTS: Of the 43 patients included in the study, diabetes mellitus was present in 83.7%. Pseudomonas aeruginosa was grown in 67.4% of patients. All 43 patients underwent computed tomography and magnetic resonance imaging (with contrast) scans. Surgical intervention was undertaken in 25.6% of patients. Mean follow-up was 10 months (SD, ±7 months). Of the 43 patients, 79.1% made a full recovery and were discharged. Relapse occurred in 9.3% of patients. One patient died because of a myocardial infarction 4 months after treatment. The mean length of stay was significantly lower after the protocol was introduced (25.6±5.3 vs. 14.2±3.8 days, p=0.001), and the duration of treatment was also significantly lower after the protocol (21.2±6.8 vs. 14.3±4.3 weeks, p=0.01). CONCLUSION: The introduction of a dedicated management protocol and joint care with otorhinolaryngology and infectious diseases resulted in improved care and decreased length of stay in patients. Early diagnosis and involvement with the relevant teams as well as prompt intervention are the key factors that reduce morbidity and mortality.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:In-Data-Review
[do] DOI:10.5152/iao.2017.4399


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