Database : MEDLINE
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[PMID]: 29520834
[Au] Autor:Tahas SA; Hetzel U; Altenbrunner-Martinek B; Martin Jurado O; Hammer S; Arif A; Hatt JM; Clauss M
[Ad] Address:Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
[Ti] Title:Microanatomy of the digestive tract, hooves and some visceral organs of addax antelope (Addax nasomaculatus) following a concentrate or forage feeding regime.
[So] Source:Anat Histol Embryol;, 2018 Mar 08.
[Is] ISSN:1439-0264
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Subacute ruminal acidosis is a common disease in captive non-domesticated ruminants and is mainly diagnosed by rumen fluid pH and rumen histology. Furthermore, differences in ruminant gastrointestinal histology have been hypothesized to correlate with the browser-grazer continuum. Twelve surplus addax antelope (Addax nasomaculatus) were divided into two groups, fed either their usual diet, consisting of a concentrate feed with a limited amount of hay, or a diet of unlimited hay only, for 3 months. After culling, descriptive and morphometric histology and pH measurements were compared between groups. Significant variations in cellular subpopulations were noted between groups, with roughage-fed individuals presenting primarily with balloon cells of the Stratum corneum and living layer cell vacuolization, whereas parakeratosis and intermediate-type cells were more frequent in the concentrate-fed group. Lesions typical of subacute ruminal acidosis were significantly more pronounced in concentrate-fed individuals. Ruminal pH measurements did not differ significantly, but were more consistent in forage-fed individuals, indicating a more stable reticuloruminal environment. The results indicate that ruminal histology may be more appropriate in assessing ruminal health compared to a single post-mortem pH measurement. It is proposed that Stratum corneum balloon cells may indicate cell maturation and not, as previously assumed, hyperfunction. Concentrate-fed individuals scored higher on the presence of inflammatory cells on hoof corium histology. The study further emphasizes the adaptability of ruminant digestive tract microanatomy in adult animals even after a short period of time and the positive effects an increased roughage diet may have in populations of captive grazing ruminants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/ahe.12351

  2 / 1661 MEDLINE  
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[PMID]: 29330862
[Au] Autor:Levy L; Layher H; McNiff JM; Ko CJ
[Ad] Address:Department of Dermatology, Yale University Medical School, New Haven, Connecticut.
[Ti] Title:Dermatomyositis: Histopathologic findings of parakeratosis and dermal edema revisited.
[So] Source:J Cutan Pathol;45(4):282-285, 2018 Apr.
[Is] ISSN:1600-0560
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The cutaneous manifestations of dermatomyositis range from classical in the case of heliotrope rash and Gottron papules to less common papulosquamous and edematous/vesiculobullous lesions; histopathologic descriptions are dominated by interface dermatitis. We present a case of dermatomyositis with a combination of common and rare skin findings, both clinically and histologically. Increased awareness of papulosquamous and edematous lesions of dermatomyositis can help direct patient care. Although uncommon, confluent parakeratosis and dermal edema can be manifestations of dermatomyositis.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process
[do] DOI:10.1111/cup.13104

  3 / 1661 MEDLINE  
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[PMID]: 29439292
[Au] Autor:Yang L; Fanok MH; Mediero-Munoz A; Fogli LK; Corciulo C; Abdollahi S; Cronstein BN; Scher JU; Koralov SB
[Ad] Address:Department of Pathology, NYU School of Medicine, New York, NY, 10016.
[Ti] Title:Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.
[So] Source:Arthritis Rheumatol;, 2018 Feb 13.
[Is] ISSN:2326-5205
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To introduce a novel pre-clinical animal model of psoriatic arthritis, R26STAT3C CD4Cre mice, and investigate the role of Th17 cytokines in the disease pathogenesis. METHODS: We characterized a novel murine model of Th17-driven cutaneous and synovio-entheseal disease directed by T cell-specific expression of a hyperactive STAT3 allele. By crossing R26STAT3C CD4Cre mice onto an IL-22 knockout background or treating them with a neutralizing antibody against IL-17, we interrogated how these Th17 cytokines contribute to disease pathogenesis. RESULTS: R26STAT3C CD4Cre mice develop acanthosis, hyperkeratosis, and parakeratosis of the skin, as well as, enthesitis/tendonitis and peri-articular bone erosion in different joints accompanied by osteopenia. T cell-specific expression of a hyperactive STAT3C allele drives an augmented Th17 response in these animals. Careful characterization revealed an increase in osteoclast progenitor (OCP) cells and RANKL producing cells that contributed to the osteopenic phenotype observed in the mutant animals. Abrogation of Th17 cytokines, IL-17 or IL-22, improved both skin and bone phenotype in the R26STAT3C CD4Cre mice, revealing a central role of Th17 cells in the regulation of OCP numbers and RANKL expression on stromal cells. CONCLUSION: Perturbation of the IL-23/Th17 axis instigates Th17-mediated inflammation in R26STAT3C CD4Cre mice, leading to cutaneous and synovio-entheseal inflammation, and bone pathology highly reminiscent of psoriatic arthritis. Both IL-17A and IL-22 produced by Th17 cells play critical roles in promoting the cutaneous and musculoskeletal inflammation that characterizes psoriatic arthritis.. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher
[do] DOI:10.1002/art.40447

  4 / 1661 MEDLINE  
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[PMID]: 29430682
[Au] Autor:Tohgasaki T; Ozawa N; Yoshino T; Ishiwatari S; Matsukuma S; Yanagi S; Fukuda H
[Ad] Address:FANCL Research Institute.
[Ti] Title:Enolase-1 expression in the stratum corneum is elevated with parakeratosis of atopic dermatitis and disrupts the cellular tight junction barrier in keratinocytes.
[So] Source:Int J Cosmet Sci;, 2018 Feb 11.
[Is] ISSN:1468-2494
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Previous studies have shown that enolase-1 (ENO1) in the stratum corneum (SC) is more highly expressed in patients with atopic dermatitis (AD) than in healthy individuals, suggesting that it is a novel biomarker for evaluating skin condition in patients with AD. However, the mechanism underlying high ENO1 expression in the SC and its pathological relevance in AD are unclear. In this study, the relationship between ENO1 expression and keratinization of epidermis was investigated and the role of high ENO1 expression in keratinocytes was characterized. METHODS: ENO1 expression and morphological characteristics were examined in SC from the cheeks of 24 patients with AD. Additionally, the localization of ENO1 in the excised human epidermis was observed. Moreover, to analyze the role of ENO1 in cellular barrier function, tight junction proteins (TJs) and trans-epithelial electrical resistance (TEER) in keratinocytes with ENO1 overexpression were evaluated. Furthermore, the localization of ENO1 and plasminogen in keratinocytes was evaluated by immunostaining, and the cellular barrier function in keratinocytes was examined after treatment with tranexamic acid (TXA). RESULTS: ENO1 expression was substantially correlated with the rate of nucleated corneocytes in AD. In addition, ENO1 localized in the basal to spinous layers, but was its expression dramatically decreased in healthy human SC. ENO1 overexpression in human epidermal keratinocytes reduced the expression of TJs (claudin-4, E-cadherin, tricellulin, and occludin) and TEER, and treatment with anti-ENO1 IgG reversed these effects. ENO1 co-localized with plasminogen in keratinocytes. Treatment with TXA rescued the ENO1-induced reductions in TJ and TEER expression. CONCLUSION: We found a substantial correlation between ENO1 expression and the rate of nucleated corneocytes in AD and decreased ENO1 expression with nuclear disappearance. These results suggest that high ENO1 expression in the SC of AD is caused by deficient keratinization, which is an AD characteristic. Moreover, ENO1 overexpression in keratinocytes promoted dysfunction of TJ dynamics, leading to reduced integrity of the cellular barrier, and these effects might be mediated by plasmin activity. We propose that ENO1 is a useful indicator of parakeratosis and might have a potential role in cellular TJ barrier function in the epidermis. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1111/ics.12449

  5 / 1661 MEDLINE  
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[PMID]: 29423952
[Au] Autor:Bauer A; Nimmo J; Newman R; Brunner M; Welle MM; Jagannathan V; Leeb T
[Ad] Address:Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.
[Ti] Title:A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis.
[So] Source:Anim Genet;, 2018 Feb 09.
[Is] ISSN:1365-2052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hereditary nasal parakeratosis (HNPK), described in the Labrador Retriever breed, is a monogenic autosomal recessive disorder that causes crusts and fissures on the nasal planum of otherwise healthy dogs. Our group previously showed that this genodermatosis may be caused by a missense variant located in the SUV39H2 gene encoding a histone 3 lysine 9 methyltransferase, a chromatin modifying enzyme with a potential role in keratinocyte differentiation. In the present study, we investigated a litter of Greyhounds in which six out of eight puppies were affected with parakeratotic lesions restricted to the nasal planum. Clinically and histologically, the lesions were comparable to HNPK in Labrador Retrievers. Whole genome sequencing of one affected Greyhound revealed a 4-bp deletion at the 5'-end of intron 4 of the SUV39H2 gene that was absent in 188 control dog and three wolf genomes. The variant was predicted to disrupt the 5'-splice site with subsequent loss of SUV39H2 function. The six affected puppies were homozygous for the variant, whereas the two non-affected littermates were heterozygous. Genotyping of a larger cohort of Greyhounds revealed that the variant is segregating in the breed and that this breed might benefit from genetic testing to avoid carrier × carrier matings.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher
[do] DOI:10.1111/age.12643

  6 / 1661 MEDLINE  
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[PMID]: 29193195
[Au] Autor:Chahal S; Tallon B
[Ad] Address:Department of Dermatopathology, Pathlab Bay of Plenty, Tauranga, New Zealand.
[Ti] Title:Presence of stratum corneum serum in non-palmoplantar psoriasis.
[So] Source:J Cutan Pathol;45(3):208-211, 2018 Mar.
[Is] ISSN:1600-0560
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Psoriasis is a common, chronic skin eruption characterized by abnormal hyperproliferation of the epidermis. When assessing psoriasis histologically, it is historically considered a "dry" disease, with significant amounts of serum not expected within lesional stratum corneum. However, this specific feature is not often mentioned within the literature. A retrospective study was undertaken to assess prevalence of serum within stratum corneum in cases of non-palmoplantar psoriasis. METHODS: We evaluated 27 specimens diagnosed histologically as psoriasis between January 2015 and June 2016. In addition to serum, we assessed for psoriasiform hyperplasia, hypogranulosis, suprapapillary thinning and parakeratosis with neutrophils. The cases were then categorized as either diagnostic for, or consistent with, psoriasis and were followed up with clinicians to assess whether the clinical course was consistent with psoriasis. RESULTS: A total of 27 hematoxylin and eosin (H&E)-stained biopsies were examined from 21 patients, with periodic acid-Schiff (PAS) performed on 20 of the biopsies. Of these, 12 biopsies had serum present (44.4%). Of the 12 lesions considered to clinically and histologically represent psoriasis, 5 (41.7%) had serum. CONCLUSION: Our results suggest serum within stratum corneum is possibly an acceptable feature within the spectrum of psoriasis histopathology and should not necessarily detract from the diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:In-Process
[do] DOI:10.1111/cup.13088

  7 / 1661 MEDLINE  
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[PMID]: 29415945
[Au] Autor:Ji M; Xue N; Lai F; Zhang X; Zhang S; Wang Y; Jin J; Chen X
[Ad] Address:State Key laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.
[Ti] Title:Validating a selective S1P receptor modulator Syl930 for psoriasis treatment.
[So] Source:Biol Pharm Bull;, 2018 Feb 07.
[Is] ISSN:1347-5215
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Psoriasis is a chronic inflammatory skin disease characterized by red, scaly and raised plaques. Thus far, T-cell infiltration is one of the most prominent pathogenic triggers, however, the exact molecular mechanisms underlying psoriasis have not been clearly established. Sphingolipid sphingosine-1-phosphate (S1P) is a lysophospholipid regulator modulating a variety of immune cell trafficking via interactions with its cognate receptors, S1P . Activation of S1P signaling has recently emerged as a novel therapeutic avenue for psoriasis treatment. Here, we test a newly developed selective S1P agonist, Syl930, in four different psoriasis animal models. Our data reveals that oral administration of Syl930 can induce strong anti-proliferative and anti-inflammatory effects. Specifically, Syl930 decreases the pathological thickening of back skin induced by sodium lauryl sulfate (SLS), inhibits the proliferation of basal cells in a vaginal epithelium model and increases the granular layer scales in a mouse tail assay. Moreover, Syl930 can ameliorate the parakeratosis and acanthosis as well as improve granular layer composition and decrease the thickening of epidermis in a propranolol-induced guinea pig psoriasis model. Therefore, we demonstrate that Syl930 is a promising candidate for psoriasis therapy in clinical.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1248/bpb.b17-00939

  8 / 1661 MEDLINE  
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[PMID]: 29242945
[Au] Autor:Berkers T; Visscher D; Gooris GS; Bouwstra JA
[Ad] Address:Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, NL-2333 CC Leiden, The Netherlands.
[Ti] Title:Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum.
[So] Source:Acta Derm Venereol;, 2017 Dec 15.
[Is] ISSN:1651-2057
[Cp] Country of publication:Sweden
[La] Language:eng
[Ab] Abstract:Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense lateral lipid organization. In addition, parakeratosis was occasionally observed. The present study investigated whether the extent of initial barrier disruption affects lipid organization and parakeratosis in regenerated stratum corneum. After barrier disruption and stratum corneum regeneration the fraction of lipids adopting a less dense lateral organization gradually increased with increasing degree of barrier disruption. Only when 75% of the stratum corneum was removed, were parakeratosis and a change in lamellar organization observed. This demonstrates the possibility of using the skin barrier repair model to study the effects of formulations on compromised skin in which the presence of parakeratosis and lipid organization can be modified by the extent of barrier disruption.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171215
[Lr] Last revision date:171215
[St] Status:Publisher
[do] DOI:10.2340/00015555-2865

  9 / 1661 MEDLINE  
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[PMID]: 29178413
[Au] Autor:Pan ZY; Dong DK; Chen SJ; Lu LY; Hu TT; Ju Q
[Ad] Address:Department of Dermatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Title:In vivo reflectance confocal microscopy in daily practice: Image features correlated to histopathology.
[So] Source:Skin Res Technol;, 2017 Nov 27.
[Is] ISSN:1600-0846
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: In vivo reflectance confocal microscopy (RCM) represents a promising technique for noninvasive visualization of skin lesions. In the clinical daily practice, doctors want to know the relationship between the RCM images and the skin pathological changes. OBJECTIVE: The aim of this study was to identify the basic skin pathological changes under RCM, and use RCM terminology to describe these pathological changes. METHODS: A total of 100 patients were recruited and were evaluated both by RCM and histopathologic examination. Ten healthy volunteers were also recruited as control. RCM examinations were done and biopsies of the lesions at the same site of RCM examination were performed for histopathology analysis. RESULTS: The pathological changes including hyperkeratosis, parakeratosis, acanthosis, papilloma, spongiosis, pustule, vacuolar degeneration, hyperpigmentation, changes of collagen fibers, and vascular changes can be imaged by RCM and corresponded well to their histopathology. RCM failed to find the atypical keratinocytes in two squamous cell carcinoma cases because of the hyperkeratosis and failed to find the vascular changes in one port wine stain cases because of the limitation of detecting depth. CONCLUSION: Features correlating well to histopathology are observed on RCM. RCM can be used as an auxiliary diagnosis tool for the clinical diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171127
[Lr] Last revision date:171127
[St] Status:Publisher
[do] DOI:10.1111/srt.12417

  10 / 1661 MEDLINE  
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[PMID]: 29138996
[Au] Autor:Eber AE; Rosen A; Oberlin KE; Giubellino A; Romanelli P
[Ad] Address:Department of Dermatology and Cutaneous Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL, 33136, USA. a.eber@med.miami.edu.
[Ti] Title:Ichthyosiform Pityriasis Rubra Pilaris-Like Eruption Secondary to Ponatinib Therapy: Case Report and Literature Review.
[So] Source:Drug Saf Case Rep;4(1):19, 2017 Nov 14.
[Is] ISSN:2199-1162
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Tyrosine kinase inhibitors have revolutionized the chemotherapy arena as targeted therapies for a multitude of malignancies. They are more selective than conventional chemotherapy, and often elicit fewer systemic adverse events, however toxicities still exist. Cutaneous toxicities are common and their management presents a novel challenge to physicians and patients. Ponatinib is a third-generation tyrosine kinase inhibitor increasingly reported to cause cutaneous eruption. A 50-year-old woman with a history of chronic myelogenous leukemia presented with a 4-month history of worsening atrophic and ichthyosiform pink plaques involving the axillae, thighs and abdomen; red patches were also observed on the cheeks and forehead. She was started on the third-generation, ponatinib, 5 months earlier because of disease refractory to previous therapies including interferon, imatinib, dasatinib and bosutinib. A skin biopsy revealed perifollicular fibrosis, alternating orthokeratosis and parakeratosis, and a sparse perivascular lymphocytic infiltrate consistent with a pityriasis rubra pilaris-like reaction. Topical tretinoin 0.025% cream was initiated, resulting in resolution within 3 weeks without discontinuation of ponatinib. A review of previous reports identified significant similarities among the ponatinib-induced drug reactions. Here, we highlight not only that cutaneous eruptions occur on ponatinib therapy, but that the dermatologic manifestations are characteristic and unique, and benefit from retinoid therapy, without requiring interruption of vital chemotherapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1007/s40800-017-0055-y


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