Database : MEDLINE
Search on : Paratuberculosis [Words]
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[PMID]: 29519720
[Au] Autor:Bo M; Niegowska M; Arru G; Sechi E; Mariotto S; Mancinelli C; Farinazzo A; Alberti D; Gajofatto A; Ferrari S; Capra R; Monaco S; Sechi G; Sechi LA
[Ad] Address:Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
[Ti] Title:Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder.
[So] Source:J Neuroimmunol;, 2018 Feb 28.
[Is] ISSN:1872-8421
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP , IRF5 ) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs. 5%, p < 0.0002 and 50% vs. 2%, p < 0.0001, respectively), while, unlike in MS, responsiveness to EBV was similar.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  2 / 3547 MEDLINE  
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[PMID]: 29519503
[Au] Autor:Park HT; Park HE; Jung YH; Yoo HS
[Ad] Address:Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
[Ti] Title:An ISMap02-like insertion sequence in Mycobacterium spp. interferes with specific detection of Mycobacterium avium subsp. paratuberculosis.
[So] Source:Vet Microbiol;216:1-6, 2018 Mar.
[Is] ISSN:1873-2542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Mycobacterium avium subsp. paratuberculosis (MAP) is a causative agent of Johne's disease or paratuberculosis (PTB), which is a chronic debilitating disease in ruminants, that is characterized by incurable enteritis and persistent diarrhea. ISMap02 is one of the major targets of PCR because it is present in multicopies (six copies) and known to be specific to MAP. However, in the present study, non-MAP mycobacteria were shown to be positive by ISMap02 targeting PCR. Two bacterial isolates (Sample ID: BO-038 and BO-042) were cultured from bovine fecal samples that produced positive results in three of two ISMap02 targeting PCR analyses with negative results in IS900 real-time PCR. Species identification using 16S rRNA gene sequencing and hsp65 gene partial sequencing revealed that strains BO-038 and BO-042 were M. virginiense and M. nonchromogenicum, respectively, which both belong to the M. terrae complex (MTC). Moreover, the two isolates shared a novel insertion sequence (IS) with high similarity to some parts of nucleotide sequences of ISMap02, and IS was presumed to be identical to that present in M. heraklionense. Both the novel IS and ISMap02 were characterized as IS1182 family members, and several sequences similar to ISMap02 were identified by BLAST analysis. In addition, the DDE transposase of the novel IS showed great similarity in the N-terminal portion with the IS5/1182 DDE transposase of other mycobacteria. These results suggest that ISMap02 has a conserved region with similarity to other ISs, and that the diagnostic value of the primer sets targeting that region should be re-addressed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process

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[PMID]: 29514687
[Au] Autor:Marquetoux N; Mitchell R; Ridler A; Heuer C; Wilson P
[Ad] Address:EpiCentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. nelly.marquetoux@gmail.com.
[Ti] Title:A synthesis of the patho-physiology of Mycobacterium avium subspecies paratuberculosis infection in sheep to inform mathematical modelling of ovine paratuberculosis.
[So] Source:Vet Res;49(1):27, 2018 Mar 07.
[Is] ISSN:1297-9716
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This literature review of exposure to Mycobacterium avium subsp. paratuberculosis (MAP) in sheep enabled a synthesis of the patho-physiology of ovine paratuberculosis (PTB). These results could be used to inform subsequent modelling of ovine PTB. We reviewed studies of both experimental and natural exposure. They were generally comparable. Possible outcomes following exposure were latent infection, i.e. mere colonization without lesions; active infection, with inflammatory histopathology in the intestinal tissues resulting in mild disease and low faecal shedding; and affection, with severe intestinal pathology, reduced production, clinical signs and high faecal shedding. Latent infection was an uninformative outcome for modelling. By contrast, histological lesions and their grade appeared to be a good marker of active infection and progression stages to clinical disease. The two possible pathways following infection are non-progression leading to recovery and progression to clinical disease, causing death. These pathwaysare mediated by different immune mechanisms. This synthesis suggested that host-related characteristics such as age at exposure and breed, combined with pathogen-related factors such as MAP dose, strain and inoculum type for experimental infection, have a strong influence on the outcome of exposure. The material reviewed consisted of disparate studies often with low numbers of sheep and study-level confounders. Hence comparisons between and across studies was difficult and this precluded quantitative model parameter estimation. Nevertheless, it allowed a robust synthesis of the current understanding of patho-physiology of ovine PTB, which can inform mathematical modelling of this disease.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1186/s13567-018-0522-1

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[PMID]: 28454560
[Au] Autor:Corbett CS; De Buck J; Orsel K; Barkema HW
[Ad] Address:Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
[Ti] Title:Fecal shedding and tissue infections demonstrate transmission of Mycobacterium avium subsp. paratuberculosis in group-housed dairy calves.
[So] Source:Vet Res;48(1):27, 2017 04 28.
[Is] ISSN:1297-9716
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Current Johne's disease control programs primarily focus on decreasing transmission of Mycobacterium avium subsp. paratuberculosis (MAP) from infectious adult cows to susceptible calves. However, potential transmission between calves is largely overlooked. The objective was to determine the extent of MAP infection in calves contact-exposed to infectious penmates. Thirty-two newborn Holstein-Friesian calves were grouped into 7 experimental groups of 4, consisting of 2 inoculated (IN) calves, and 2 contact-exposed (CE) calves, and 1 control pen with 4 non-exposed calves. Calves were group housed for 3months, with fecal samples were collected 3 times per week, blood and environmental samples weekly, and tissue samples at the end of the trial. The IN calves exited the trial after 3months of group housing, whereas CE calves were individually housed for an additional 3months before euthanasia. Control calves were group-housed for the entire trial. All CE and IN calves had MAP-positive fecal samples during the period of group housing; however, fecal shedding had ceased at time of individual housing. All IN calves had MAP-positive tissue samples at necropsy, and 7 (50%) of the CE had positive tissue samples. None of the calves had a humoral immune response, whereas INF-γ responses were detected in all IN calves and 5 (36%) CE calves. In conclusion, new MAP infections occurred due to exposure of infectious penmates to contact calves. Therefore, calf-to-calf transmission is a potential route of uncontrolled transmission on cattle farms.
[Mh] MeSH terms primary: Bacterial Shedding
Cattle Diseases/transmission
Dairying
Feces/microbiology
Housing, Animal
Paratuberculosis/transmission
[Mh] MeSH terms secundary: Animals
Cattle
Cattle Diseases/microbiology
Female
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis/microbiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1709
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-017-0431-8

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[PMID]: 29508438
[Au] Autor:Azimi T; Nasiri MJ; Chirani AS; Pouriran R; Dabiri H
[Ad] Address:Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Title:The role of bacteria in the inflammatory bowel disease development: a narrative review.
[So] Source:APMIS;, 2018 Mar 06.
[Is] ISSN:1600-0463
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Inflammatory bowel disease (IBD) is a general term used for the ulcerative colitis (UC) and Crohn's disease (CD); in addition, IBD principally refers to a chronic disease of the gastrointestinal tract in which mediated by immune system. Consequently, IBD could progress in individuals who are genetically prone. Infections role in the development of inflammatory disease of the gastrointestinal tract has been studied by quite many clinical studies; furthermore, the possible role of some pathogens in the development and exacerbation of the inflammatory disease of the gastrointestinal tract have been described. Evidently, the most indispensable pathogens that could be associated with the IBD disease, Mycobacterium avium subspecies paratuberculosis, Clostridium difficile, Escherichia coli, Listeria monocytogenes, Campylobacter concisus; as well as viruses, such as, cytomegalovirus, Epstein-Barr Virus, and measles virus are notable. A number of pathogenic parasites may also be involved in the development and progression of the disease. As a matter of fact, overexposure of immune system in the presence of excessive bacterial substances could also lead to the loss of immunological tolerance to the bacteria, which are commonly considered as the normal flora in the intestine; furthermore, it may subsequently elicit bowel inflammation and IBD development. In the current study, we discussed the most common bacterial pathogens that may be involved in the development of IBD; as well as, a comprehensive narrative review related to the evidences which support or ignore the possible role of bacteria in progression of IBD, indeed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1111/apm.12814

  6 / 3547 MEDLINE  
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[PMID]: 29458660
[Au] Autor:Karuppusamy S; Mutharia L; Kelton D; Karrow N; Kirby G
[Ad] Address:1​Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
[Ti] Title:Identification of antigenic proteins from Mycobacterium avium subspecies paratuberculosis cell envelope by comparative proteomic analysis.
[So] Source:Microbiology;164(3):322-337, 2018 Mar.
[Is] ISSN:1465-2080
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Johne's disease (JD) is a contagious, chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). The aim of this study was to identify antigenic proteins from the MAP cell envelope (i.e. cell wall and cytoplasmic membranes) by comparing MAP, M. avium subsp. hominissuis (MAH) and M. smegmatis (MS) cell envelope protein profiles using a proteomic approach. Composite two-dimensional (2D) difference gel electrophoresis images revealed 13 spots present only in the image of the MAP cell envelope proteins. Using serum from MAP-infected cattle, immunoblot analysis of 2D gels revealed that proteins in the 13 spots were antigenic. These proteins were identified by liquid chromatography tandem mass spectrometry as products of the following genes: sdhA, fadE25_2, mkl, citA, gapdh, fadE3_2, moxR1, mmp, purC, mdh, atpG, fbpB and desA2 as well as two proteins without gene names identified as transcriptional regulator (MAP0035) protein and hypothetical protein (MAP1233). Protein functions ranged from energy generation, cell wall biosynthesis, protein maturation, bacterial replication and invasion of epithelial cells, functions considered essential to MAP virulence and intracellular survival. Five MAP cell envelope proteins, i.e. SdhA, FadE25_2, FadE3_2, MAP0035 and DesA2 were recombinantly expressed, three of which, i.e. SdhA, FadE25_2 and DesA2, were of sufficient purity and yield to generate polyclonal antibodies. Immunoblot analysis revealed antibodies reacted specifically to the respective MAP cell envelope proteins with minimal cross-reactivity with MAH and MS cell envelope proteins. Identification and characterization of MAP-specific proteins and antibodies to those proteins may be useful in developing new diagnostic tests for JD diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:In-Data-Review
[do] DOI:10.1099/mic.0.000606

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[PMID]: 29479518
[Au] Autor:Samba-Louaka A; Robino E; Cochard T; Branger M; Delafont V; Aucher W; Wambeke W; Bannantine JP; Biet F; Hchard Y
[Ad] Address:Universit de Poitiers, Laboratoire Ecologie et Biologie des Interactions, UMR Centre National de la Recherche Scientifique 7267, Equipe Microbiologie de l'Eau, Poitiers, France.
[Ti] Title:Environmental subsp. Hosted by Free-Living Amoebae.
[So] Source:Front Cell Infect Microbiol;8:28, 2018.
[Is] ISSN:2235-2988
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:subsp. is responsible for paratuberculosis in animals. This disease, leading to an inflammation of the gastrointestinal tract, has a high impact on animal health and an important economic burden. The environmental life cycle of subsp. is poorly understood and several studies suggest that free-living amoebae (FLA) might be a potential environmental host. FLA are protozoa found in water and soil that are described as reservoirs of pathogenic and non-pathogenic bacteria in the environment. Indeed, bacteria able to survive within these amoebae would survive phagocytosis from immune cells. In this study, we assessed the interactions between several strains of subsp. and . The results indicate that the bacteria were able to grow within the amoeba and that they can survive for several days within their host. To explore the presence of subsp. in environmental amoebae, we sampled water from farms positive for paratuberculosis. A subsp. strain was detected within an environmental amoeba identified as related to the poorly described genus. The bacterial strain was genotyped, showing that it was similar to previous infectious strains isolated from cattle. In conclusion, we described that various subsp. strains were able to grow within amoebae and that these bacteria could be found on farm within amoebae isolated from the cattle environment. It validates that infected amoebae might be a reservoir and vector for the transmission of subsp. .
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review
[do] DOI:10.3389/fcimb.2018.00028

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[PMID]: 29366791
[Au] Autor:Ganareal TACS; Balbin MM; Monserate JJ; Salazar JR; Mingala CN
[Ad] Address:Department of Chemistry, College of Arts and Sciences, Central Luzon State University, Science City of Muoz 3120, Nueva Ecija, Philippines.
[Ti] Title:Gold nanoparticle-based probes for the colorimetric detection of Mycobacterium avium subspecies paratuberculosis DNA.
[So] Source:Biochem Biophys Res Commun;496(3):988-997, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Gold nanoparticle (AuNP) is considered to be the most stable metal nanoparticle having the ability to be functionalized with biomolecules. Recently, AuNP-based DNA detection methods captured the interest of researchers worldwide. Paratuberculosis or Johne's disease, a chronic gastroenteritis in ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), was found to have negative effect in the livestock industry. In this study, AuNP-based probes were evaluated for the specific and sensitive detection of MAP DNA. AuNP-based probe was produced by functionalization of AuNPs with thiol-modified oligonucleotide and was confirmed by Fourier-Transform Infrared (FTIR) spectroscopy. UV-Vis spectroscopy and Scanning Electron Microscopy (SEM) were used to characterize AuNPs. DNA detection was done by hybridization of 10 L of DNA with 5 L of probe at 63 C for 10 min and addition of 3 L salt solution. The method was specific to MAP with detection limit of 103 ng. UV-Vis and SEM showed dispersion and aggregation of the AuNPs for the positive and negative results, respectively, with no observed particle growth. This study therefore reports an AuNP-based probes which can be used for the specific and sensitive detection of MAP DNA.
[Mh] MeSH terms primary: Colorimetry/methods
DNA/genetics
DNA/isolation & purification
Gold/chemistry
Metal Nanoparticles/chemistry
Mycobacterium avium/genetics
Mycobacterium avium/isolation & purification
[Mh] MeSH terms secundary: Biosensing Techniques/methods
In Situ Hybridization/methods
Molecular Probe Techniques
Molecular Probes/chemistry
Reproducibility of Results
Sensitivity and Specificity
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Molecular Probes); 7440-57-5 (Gold); 9007-49-2 (DNA)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:180126
[St] Status:MEDLINE

  9 / 3547 MEDLINE  
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[PMID]: 29445012
[Au] Autor:Fox NJ; Caldow GL; Liebeschuetz H; Stevenson K; Hutchings MR
[Ad] Address:Scotland's Rural College (SRUC), Edinburgh, UK.
[Ti] Title:Counterintuitive increase in observed subspecies prevalence in sympatric rabbits following the introduction of paratuberculosis control measures in cattle.
[So] Source:Vet Rec;, 2018 Feb 14.
[Is] ISSN:2042-7670
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Paratuberculosis (Johne's disease) is caused by the bacterium subspecies ( ). Achieving herd-level control of mycobacterial infection is notoriously difficult, despite widespread adoption of test-and-cull-based control strategies. The presence of infection in wildlife populations could be contributing to this difficulty. Rabbits are naturally infected with the same strain as cattle, and can excrete high levels in their faeces. The aim of this study is to determine if implementation of paratuberculosis control in cattle leads to a decline in infection levels in rabbits. An island-wide, test-and-cull-based paratuberculosis control programme was initiated on a Scottish island in 2008. In this study annual tests were obtained from 15 cattle farms, from 2008 to 2011, totalling 2609 tests. Rabbits (1564) were sampled from the 15 participating farms, from 2008 to 2011, and was detected by faecal culture. seroprevalence in cattle decreased from 16 to 7.2 per cent, while prevalence in rabbits increased from 10.3 to 20.3 per cent. Results indicate that efforts to control paratuberculosis in cattle do not reduce levels in sympatric rabbits. This adds to mounting evidence that if becomes established in wild rabbit populations, rabbits represent a persistent and widespread source of infection, potentially impeding livestock control strategies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:Publisher

  10 / 3547 MEDLINE  
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[PMID]: 29275033
[Au] Autor:Fecteau ME
[Ad] Address:Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: mfecteau@vet.upenn.edu.
[Ti] Title:Paratuberculosis in Cattle.
[So] Source:Vet Clin North Am Food Anim Pract;34(1):209-222, 2018 Mar.
[Is] ISSN:1558-4240
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Paratuberculosis remains one of the most important diseases of cattle worldwide. In cattle, the disease is debilitating and is characterized by weight loss and chronic diarrhea in the later stages of infection. However, cattle in the subclinical stages of the disease often show decreased milk production and are at higher risk for development of other common production diseases. Infections with Mycobacterium avium ssp paratuberculosis are difficult to control because of long incubation periods, the absence of clinical signs until advanced stages of the disease, and the lack of completely reliable diagnostic methods in the preclinical stages of the disease.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Process


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