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[PMID]: 25372648
[Au] Autor:Wu DX; Wu LF; Yang ZX
[Ad] Address:Department of Dermatology, Tongxiang Dermatology Hospital, Jiaxing 314500, China.
[Ti] Title:[Association between androgenetic alopecia and metabolic syndrome: a meta-analysis].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):597-601, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the association between androgenetic alopecia (AGA) and metabolic syndrome (MS). METHODS:Literature on association between AGA and MS up to December 26, 2013 was searched from PubMed, Web of Knowledge, Scopus, Cochrance library, SinoMed, CNKI, Wanfang and VIP databases, and the studies met the eligibility criteria were selected. Meta-analysis was performed by using StataSE 12.0 software to determine the association between AGA and MS. RESULTS:Four case-control studies and 2 cross-sectional studies met the eligibility criteria, including 950 AGA subjects and 3056 control subjects were entered the analysis. Meta-analysis showed that AGA was significantly correlated with MS(OR=2.70, 95%CI: 1.67-4.37, P<0.01). Stratification analysis showed that AGA was significantly correlated with MS in male(OR=2.30, 95%CI: 1.33-3.98, P<0.01) and female subjects(OR=4.61, 95%CI: 1.26-16.94, P<0.05); and AGA was significantly correlated with MS in European(OR=5.29, 95%CI: 2.86-9.80, P<0.01)and Asian subjects(OR=1.92, 95%CI: 1.18-3.10, P<0.01). CONCLUSION:Based on the available data, AGA may be a risk factor for MS, indicating that AGA patients would be a targeting population for screening of metabolic syndrome.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 4017971 MEDLINE  
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[PMID]: 25372647
[Au] Autor:Xu XW; Pan Y; Chen K; Cai JQ; Wu D; Zhang RC; Mou YP
[Ad] Address:Department of General Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China....
[Ti] Title:[Research progress of negative costimulator B7-H4 in urologic tumors].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):591-6, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To compare the safety and efficacy of totally laparoscopic distal gastrectomy(TLDG)with laparoscopic assisted distal gastrectomy(LADG)for gastric cancer by meta-analysis. METHODS:The literature on comparative studies of TLDG and LADG up to June 2014 were extensively retrieved from database PubMed, Cochrane library, Web of Science, and Biosis Previews. The operation time,blood loss,time to flatus, time to first oral intake,postoperative hospital stay,postoperative morbidity,times of analgestic requirement,pain score,and the level of C-reactive protein(CRP) on postoperative day 1 and 7 were analyzed. The statistical analysis was performed with RevMan 5.1 software. RESULTS: Seven studies met the inclusion criteria for meta-analysis. A total of 1783 Patients were included for meta-analysis,among whom 727 cases underwent TLDG and 1056 underwent LADG. Comparing with LADG,TLDG experienced less blood loss[weighted mean difference(WMD)=22.86 ml,95% confidence interval(CI): 12.0-33.72,P<0.01)],less times of analgesic requirement(WMD=0.58,95% CI: 0.35-0.81, P< 0.01),less pain score on postoperative day 1 and day 3 (day1: WMD=0.60,95% CI: 0.20-0.99,P < 0.01; day3: WMD=0.36,95% CI: 0.24-0.48,P < 0.01),earlier beginning to take diet(WMD=0.66,95% CI: 0.13-1.19,P=0.01). The operation time,postoperative hospital stay,overall morbidity and anastomosis-related morbidity,and the level of CRP on postoperative day 1 and 7 were similar between two groups(Ps>0.05). CONCLUSION:TLDG is a safe and feasible procedure with less blood loss, less pain, and quicker recovery than those of LADG.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 4017971 MEDLINE  
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[PMID]: 25372645
[Au] Autor:Wu XQ; Zhang BR
[Ad] Address:Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
[Ti] Title:[Bilateral middle cerebellar peduncle infarcts caused by bilateral vertebral artery occlusion: a case report].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):583-7, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Patients with bilateral vertebral artery occlusion have a high incidence of cerebral infarction with poor prognosis. Infarction of bilateral middle cerebellar peduncle (MCP) is extremely rare and only a few cases have been reported in literature. A 74-year-old male patient was admitted to our hospital with a chief complaint of dizziness and walking instability for 13 d. Brain magnetic resonance image showed acute bilateral middle cerebellar peduncle infarction. Digital subtraction angiography showed occlusion of the initiation part of left vertebral artery and whole right vertebral artery, while a large amount of collateral circulations and recanalization were observed. After volume expansion, anti-platelet aggregation and lipid-lowering therapy, the symptoms disappeared. The patient was followed up for 10 months and he recovered well.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25372644
[Au] Autor:Lu Z; Qiu XD; Ren YC
[Ad] Address:Fuyang Hospital of Traumatology and Orthopedics of Traditional Chinese Medicine, Fuyang 311400, China.
[Ti] Title:[Treatment of distal clavicle type Ⅱ fracture: suture anchor versus clavicular hook plate].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):577-82, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To compare the efficacy of suture anchor with clavicular hook plate in treatment of type Ⅱ fractures of the distal clavicle. METHODS:Forty patients with Neer type Ⅱ fractures of distal clavicle were treated in our hospital from May 2009 to May 2010, including 21 cases treated with suture anchors and 19 cases treated with clavicular hook plate. The time of fracture union and Constant Murley scores were compared between two groups. RESULTS:All incisions reached primary healing, and there was no infection or hematoma formation. Postoperative follow-up time was 12-24 months, mean 14.5 months. The mean time of fracture reunion in suture anchors group was 13.22.0 weeks (9-17 weeks) and that in clavicular hook plate group was 13.32.0 weeks (10-16 weeks, P>0.05). The mean postoperative Constant Murley scores in suture anchors and hook plate groups were( 91.16.5)% and (89.27.6)%, respectively(P>0.05). But the pain score in suture anchor group was higher than that in hook plate group(12.61.9 vs 11.32.3, P<0.05). CONCLUSION:Compared with claviculer hook plate, the suture anchor has good clinical results and less complications in treatment of type Ⅱ fractures of distal clavicle.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25372643
[Au] Autor:Xu X; Deng RX; Deng SM; Yang JL; Chen J
[Ad] Address:Department of Oral and Maxillofacial Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China....
[Ti] Title:[Application of three dimensional model in treatment of superolateral dislocation of mandibular condyle].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):572-6, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To assess the application of three-dimensional jaw model in treatment of superolateral dislocation of condyle. METHODS:Nine patients with superolateral dislocation of condyle and symphyseal fractures were admitted in hospital from June 2008 to June 2013. Spiral CT scan on maxilla and mandible was performed,and three-dimensional jaw model was constructed with rapid prototyping technology. According to conditions of condylar superolateral dislocation model,the operation scheme was designed. The symphyseal fracture line was made and fracture was reduced on three-dimensional jaw model. Individualized prefabricated reconstructive titanium plate was made on symphyseal fracture model. Symphyseal fracture was replaced with individualized prefabricated mandibular reconstruction titanium plate according to occlusal relationship. At the same time,reduction of condylar superolateral dislocation was accomplished. RESULTS:Operations were successfully completed in 9 cases under guidance of three dimensional jaw model surgery. Operative incision was primarily healed,and occlusal relationship was restored. Postoperative CT scan showed that the locations of condyle in 9 cases were completely restored. Patients were followed-up for 6-28 months with a median of 18 months. The maximum of mouth opening was 3.1- 4.2 cm with a medians of 3.3 cm,and the occlusal relationship of all patients was normal after surgery. CONCLUSION: Three-dimensional jaw model can show complete status of condylar superolateral dislocation and symphyseal fracture. The model can accurately shape symphyseal reconstructive titanium plate and restore condylar superolateral dislocation during reductive surgery.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 4017971 MEDLINE  
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[PMID]: 25372642
[Au] Autor:Zhu PH; Huang JY; Ye M; Zheng ZL
[Ad] Address:Department of Ultrasonography,Zhejiang Hospital,Hangzhou 310013,China....
[Ti] Title:[Assessment of left ventricular twist in type 2 diabetes mellitus by using two-dimensional ultrasound speckle tracking imaging].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):566-71, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To evaluate the left ventricular twist characteristics in patients with type 2 diabetes by using two-dimensional speckle tracking imaging (STI). METHODS:Ninety-three patients with type 2 diabetes admitted in Zhejiang Hospital from May 2012 to September 2013 were enrolled. According to left ventricular ejection fraction (LVEF),patients were divided into two groups: normal left ventricular systolic function group(group A,LVEF≥0.50,n=46 ) and abnormal left ventricular systolic function group(group B,LVEF <0.50,n=47 ). Forty-six healthy subjects were selected as normal controls. STI was applied to quantitatively analyze the left ventricular twist. Correlation of the peak of left ventricular twist angle(Peaktw),aortic valve closure time twist angle(AVCtw),and mitral valve opening time twist angle(MVOtw)with LVEF,Tei index,E/A,and E/e was evaluated. Consistency check for STI was conducted to assess its stability and reliability. RESULTS:The Peaktw,AVCtw,and MVOtw in group A were significantly elevated than those in normal controls (P<0.05). The Peaktw,AVCtw,and MVOtw in group B was lower than those in normal controls and group A (P<0.05). In diabetic patients,the Peaktw,AVCtw,MVOtw were positively correlated with LVEF (r=0.968,0.966,0.938;P<0.05)and E/A (r=0.798,0.790,0.788; P<0.05),and were negatively correlated with Tei index(r=-0.834,-0.811,-0.797; P<0.05)and E/e(r=-0.823,-0.805,-0.771; P<0.05). The agreement between measurers and within measurers of Peaktw was satisfactory(between measurers: R=0.957,bias=-0.1,95% consistency limit=-2.8-2.7; within measurer: R=0.964,bias=-0.2,95% consistency limits=-2.7-2.2). CONCLUSION: STI can be used for early recognition of abnormal changes of cardiac function in type 2 diabetic mellitus patients,with high stability and reliability.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25372641
[Au] Autor:Zheng YX; Zhang CW; Hui B; Ding BY; Ao L; Dong B; Zhou XM
[Ad] Address:Department of Biochemistry,School of Medicine,Jiaxing University,Jiaxing 314001,China....
[Ti] Title:[Roles of PIK3R1 gene in development of hepatocellular carcinoma].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):559-65, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the roles of phosphatidylinositol 3 kinase regulatory subunit alpha(PIK3R1)gene in the development of hepatocellular carcinoma (HCC). METHODS:Surgical specimens of liver cancer and corresponding pericancerous liver tissue were collected from 20 patients with hepatocellular carcinoma. Expression of p85α, encoded by PIK3R1, in HCC tissue specimens was detected by Western blotting and immunohistochemistry. HCC HepG2 cells were transfected with PIK3R1 siRNA or PIK3R1-cDNA. The expression of PIK3R1 in transfected HepG2 cells or control cells were detected by real-time PCR. Cell proliferation was evaluated by MTT,colony formation assays and flow cytometry respectively. The expression of PI3K/AKT pathway-related proteins were detected by Western blotting. RESULTS:The expression of p85α in liver tissue was higher than that in pericancerous tissues(1.270.58 vs 0.990.47,t=-3.25,P<0.05). The expression of PIK3R1 was decreased by 0.190.03 fold in PIK3R1siRNA-transfected HepG2 cells(t=46.77,P<0.05),and increased by 32.363.33 fold in PIK3R1 cDNA -transfected cells(t=-16.31, P<0.05). MTT result showed that PIK3R1 siRNA inhibited growth of HepG2 cells (0.6110.072 vs 0.8070.059,t=3.65,P<0.05),while PIK3R1 cDNA increased the cell growth(0.9370.060 vs 0.6930.065,t=-4.78,P<0.05). PIK3R1 siRNA transfected cells presented lower colony-forming efficiency than control group(3.8%0.84% vs 15.0%2.3%,t=7.92,P<0.05),while PIK3R1 cDNA transfected cells had higher colony-forming efficiency than control group(23.6%3.4% vs 12.0%1.5%,t=-5.40,P<0.05). PIK3R1 siRNA reduced the ratio of S phase cells(13.9%0.015% vs 32.9%0.07%,t=45.97,P<0.01),while PIK3R1 cDNA increased S phase cells(56.33%0.024% vs 31.94%0.042%,t=-8.73,P<0.01). PIK3R1 increased the level of p-AKT and decreased p53 level. CONCLUSION:p85α is highly expressed in HCC,and PIK3R1 gene may promote proliferation of HepG2 cells by activating PI3K/AKT pathway.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 4017971 MEDLINE  
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[PMID]: 25372640
[Au] Autor:Wu JQ; Shi J; Dong JF; Jiang YX; Zhuang SH; Yang J
[Ad] Address:Clinical Laboratory,Jinhua Hospital of Zhejiang University,Jinhua 321000,China....
[Ti] Title:[Construction of three HLA-A*0201-peptide tetramers and their preliminary application in detection of vitiligo-specific cytotoxic T lymphocytes].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):553-8, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To construct vitiligo-specific HLA-A*0201-peptide tetramers and to apply the constructed tetramers in detection of vitiligo-specific cytotoxic T lymphocytes (CTL). METHODS:Proteins HLA-A0201*-BSP and 2M were obtained by effective prokaryotic expression. The purified proteins were refolded with vitiligo antigen peptides MelanA 26-35, gp100 209-217, and tyrosinase 1-9, respectively to form HLA-A*0201-peptide complex. The complex was biotinylated by BirA enzyme and purified by gel-filtration chromatography. The tetramers were generated by mixing the complex with phycoerythrin (PE)-streptavidin at a ratio of 4∶1 and identified by Dot-blot assay. The capacity of tetramer to detect vitiligo-specific CTL was analyzed by flow cytometry. RESULTS:The biotinylation of vitiligo-specific HLA-A*0201-peptide tetramers were successfully performed by Dot-blot. Flow cytometry analysis indicated that the tetramer effectively bound to specific CTL from peripheral blood of patients with vitiligo. CONCLUSION:Three kinds of biotinylated vitiligo-specific HLA-A*0201-peptide tetramers have been constructed successfully. The tetramer can detect antigen specific CTL from patients with vitiligo.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 4017971 MEDLINE  
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[PMID]: 25372638
[Au] Autor:Zhang XQ; Pu H; Wang YP; Li JJ; Pan LA; Huang YJ; Li CL
[Ad] Address:Intensive Care Unit,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610072,China....
[Ti] Title:[Gelsolin level for prognostic evaluation in patients with critically illness].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):541-5, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the changes of plasma gelsolin level in patients with critical illness and its application in prognostic evaluation. METHODS:Ninety six critically ill patients admitted in ICU of Sichuan Provincial People's Hospital from February 2012 to December 2013 were enrolled in the prospective cohort study. Plasma gelsolin levels were detected with enzyme linked immunosorbent assay (ELISA) at admission (d1), d2, d4 and d8 after admission, and also detected in blood samples of 186 healthy subjects as controls. Logistic regression model was used to analyze the relationship between the level of plasma gelsolin and prognosis of patients. RESULTS:The average levels of plasma gelsolin were significantly lower in critically ill patients than those in control subjects (F=1986.37, P<0.01). There was significant difference in overall level of gelsolin between survival patients and fatal patients (F=16.691, P<0.01). APACHE Ⅱ score was associated with survival outcomes (r=0.489, P=0.009); the APACHE Ⅱ score was significantly higher in fatal patients than that in survival patients (29.57.7 vs 22.15.7, t=5.375, P<0.01). There was a negative correlation between plasma gelsolin levels and fatal outcomes (r=-0.512, P<0.01). Logistic regression analysis showed that the overall plasma gelsolin levels and the last measured level was a prognostic factor for critically ill patients (P<0.05). CONCLUSION:Plasma gelsolin levels are correlated with the severity of critically ill patients, and plasma gelsolin can be used as indicator of prognosis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 4017971 MEDLINE  
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[PMID]: 25372633
[Au] Autor:Bao FP; Pan YM; Zheng SS
[Ad] Address:Department of Anesthesiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
[Ti] Title:[Out-of-hospital cardiopulmonary resuscitation needs the ventilation].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):505-13, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Cardiopulmonary resuscitation (CPR) is series of rescue measures for saving cardiac arrest patients. Early initiation and good quality of CPR is crucial for increasing chance of survival from out-of-hospital cardiac arrest. In recent years, the CPR guidelines have changed a lot, especially in basic life support. The guideline now pays more attention on chest compression and less to ventilation. CPR with chest compression only and without mouth-to-mouth ventilation is more popular. In this article, we outline the development and recent researches of CPR. As depriving oxygen from a collapsed patient for 6 min may result in poor outcome, the average time for ambulance transport is longer (about 10 to 16 min) in China, which makes rescuers easy to feel fatigue, chest compression only CPR is not suitable in China. Though non-professional rescuers have difficulty to perform mouth-to-mouth ventilation, they generally show a willingness to do so. To strengthen public standard CPR training including mouth-to-mouth ventilation and chest compression, is most important to promote CPR in China.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review


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