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[PMID]: 25841111
[Au] Autor:Ben-Ezra M; Hamama-Raz Y; Palgi S; Palgi Y
[Ad] Address:School of Social Work, Ariel University, Ariel, Israel....
[Ti] Title:Cognitive appraisal and psychological distress among patients with irritable bowel syndrome.
[So] Source:Isr J Psychiatry Relat Sci;52(1):54-9, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: Irritable Bowel Syndrome (IBS) is a debilitating condition that affects mainly the patient's mental health and quality of life. There is a gap in the literature regarding the relationship between cognitive appraisals and adjustment to physical and psychological aspects resulting from IBS. The aim of the current study was to explore the psycho-social factors that are associated with psychological distress among IBS patients and the contribution of cognitive appraisal to their adjustment. METHODS: One hundred and three patients diagnosed with Irritable Bowel Syndrome participated in the study. Each participant filled a battery of questionnaires targeting demographic and psycho-social factors. The study variables were analyzed via hierarchical regression along with supplementary analyses of multiple mediation tests of indirect effects. RESULTS: The findings showed that psychological distress and depressive symptoms among IBS patients are better predicted by their global positive illness cognition appraisal, specific illness cognition appraisal of helplessness, resilience and to a lesser extent by social support, perceived optimism, illness cognitions appraisals of acceptance and perceived benefit. Global positive illness cognition appraisal gives us a sum of positive and negative appraisals into one unified appraisal. CONCLUSIONS: Our findings highlight the salience of cognitive appraisal and resilience in IBS psychological adjustment. It seems that IBS patients might benefit from psycho-educational interventions designed to assist them in reducing their helplessness appraisal and increasing the appraisal of their ability to cope with the symptoms of their illness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 4118595 MEDLINE  
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[PMID]: 25841110
[Au] Autor:Guez J; Hertzanu-Lati M; Lev-Wiesel R; Rabin S
[Ad] Address:Department of Psychology, Achva Academic College, Israel Beersheva Mental Health Center, Beersheva, Israel....
[Ti] Title:Dissociative Reality and Dissociative Being in Therapy for Post traumatic Patients.
[So] Source:Isr J Psychiatry Relat Sci;52(1):47-53, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:Post traumatic patients experience a wide range of symptoms, some of them existential in nature which we term "dissociative being." Many varied psychotherapeutic approaches are available for the treatment of post traumatic patients. Nevertheless, in view of this disorder's complexity, therapists face shortcomings when employing each of these therapeutic interventions. In order to understand this, we posit the principle we call "dissociative reality" for the treatment of trauma survivors. Our proposed method "speaks the patient's own language," harnessing dissociative elements to help individuals recall, re-enact and integrate traumatic experiences, where words are insufficient, while still upholding reality. We believe that this may be seen as an effective part of the therapeutic dialogue, and suggest that therapists may consider supplementing this approach in their treatment "toolkit" for patients with post traumatic stress and other trauma related disorders, irrespective of their declared therapeutic approach.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 4118595 MEDLINE  
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[PMID]: 25841109
[Au] Autor:Lowengrub KM; Stryjer R; Birger M; Iancu I
[Ad] Address:Rehovot Mental Health Center, Rehovot and the Beer Yaakov Mental Health Center, Beer Yaakov, both affiliated with the Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel....
[Ti] Title:Social Anxiety Disorder Comorbid with Schizophrenia: The Importance of Screening for This Under recognized and Under treated Condition.
[So] Source:Isr J Psychiatry Relat Sci;52(1):40-5, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: While the presence of comorbid anxiety disorders such as obsessive-compulsive disorder and panic disorder have been well described in schizophrenia, comorbid social anxiety disorder (SAD) has been less emphasized. The goal of this study was to examine the prevalence of SAD in our ambulatory population of patients with schizophrenia. METHODS: A group of 50 outpatients with schizophrenia randomly selected from our public mental health outpatient population was evaluated with the Structured Clinical Interview for DSM-IV (SCID)-schizophrenia section, the Positive and Negative Syndrome Scale (PANSS), the Schizophrenia Quality of Life Scale (SQLS), the Liebowitz Social Anxiety Scale (LSAS) and the Global Assessment of Functioning Scale (GAF). After completion of assessments, a retrospective chart review was conducted on all study patients who met criteria for a diagnosis of SAD in order to determine how many of these patients had been previously given a diagnosis of SAD. RESULTS: Based on a cutoff score of 29/30 on the total LSAS score, 38% of our sample had a comorbid diagnosis of SAD. Compared to patients who did not suffer from comorbid SAD, patients with schizophrenia and comorbid SAD had lower ratings of quality of life, but similar GAF and PANSS scores. According to the results of the chart review, none of the affected patients had been previously diagnosed with SAD. CONCLUSIONS: According to the results of our study, SAD as a comorbid condition is highly prevalent in schizophrenia and may be under-detected in the outpatient mental health care setting. Furthermore, the presence of SAD may lead to a decreased quality of life for patients with schizophrenia. Further studies should evaluate whether the diagnosis and treatment of comorbid SAD would improve the treatment and quality of life of patients with schizophrenia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 4118595 MEDLINE  
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[PMID]: 25841108
[Au] Autor:Gross R; Glasser S; Elisha D; Tishby O; Madar Jacobson D; Levitan G; Lambert MJ; M Ponizovsky A
[Ad] Address:Sheba Medical Center, Tel Hashomer, and Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel....
[Ti] Title:Validation of the Hebrew and Arabic Versions of the Outcome Questionnaire (OQ-45).
[So] Source:Isr J Psychiatry Relat Sci;52(1):33-9, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: Measuring the progress of mental health treatment aids in assessment and monitoring of psychotherapeutic outcomes. The OQ-45 is a widely accepted measure of such outcomes. The aim of this study was to validate the Hebrew and Arabic versions of the OQ-45. METHOD: Data were collected from three samples: non patient university students (n=189), university mental health clinic patients (n=37), and outpatient mental health clinic patients (n=135). Subjects completed the OQ-45 as well as the BSI and PHQ-9 questionnaires. RESULTS: Test-retest and internal reliability, and concurrent and discriminative validity of both OQ-45 versions were satisfactory. Sensitivity of the Hebrew and Arabic versions was 0.70 and 0.80, respectively, and the specificity was 0.69and 0.93, respectively. Sensitivity-to-change was noted only for the Symptom Distress (SD) subscale. LIMITATIONS: Sensitivity-to-change was not demonstrated for the total OQ-45, possibly due to a too-short follow-up period. CONCLUSIONS: Adequate psychometric properties of the Hebrew and Arabic OQ-45 suggest that they can serve as useful measures of mental health treatment in Israel.Further research is necessary to confirm norms, cut-off scores and sensitivity-to-change using a larger representative population and diverse types of treatment over a longer period of time.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 4118595 MEDLINE  
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[PMID]: 25841106
[Au] Autor:Rosenberg O; Dinur Klein L; Gersner R; Kotler M; Zangen A; Dannon P
[Ad] Address:Beer Ya'acov Mental Health Center affiliated to Sackler School of Medicine, University of Tel Aviv, Tel Aviv, Israel....
[Ti] Title:Long-term Follow-up of MDD Patients Who Respond to Deep rTMS: A Brief Report.
[So] Source:Isr J Psychiatry Relat Sci;52(1):17-23, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: Deep transcranial magnetic stimulation (dTMS) is effective in treatment of Major Depressive Disorder (MDD), and in re-treatment in case of relapse. Our study evaluates the long-term durability of dTMS in MDD. METHOD: Seventeen patients that responded to dTMS treatment evaluated. Follow-up period was 9.3 months. Patients were considered as relapsed if: HDRS (Hamilton Depression Rating Scale) score was 16 points or more, in case of change in antidepressants, hospitalization due to exacerbation, referral to ECT. RESULTS: Six months after last treatment three patients relapsed (17.6%). During the follow-up of 9.3 months, nine relapsed. Relapse rate was 5.6 per 100 person-months. Patients continued to improve in HDRS following the treatment. We have found number of treatment sessions, stimulation, age, age of depressive disorder onset, length of depressive episode prior to the first treatment, as well as number of depressive episodes to have no predictive value regarding propensity to relapse in these patients. LIMITATIONS: The study's main limitations are the relatively small sample size, patients differing in follow-up periods and the lack of a control group. CONCLUSION: Relapse rates after dTMS are comparable to pharmacotherapy and ECT.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 4118595 MEDLINE  
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[PMID]: 25841105
[Au] Autor:Amiaz R; Kent I; Rubinstein K; Sela BA; Javitt D; Weiser M
[Ad] Address:Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel....
[Ti] Title:Safety, tolerability and pharmacokinetics of open label sarcosine added on to anti-psychotic treatment in schizophrenia - preliminary study.
[So] Source:Isr J Psychiatry Relat Sci;52(1):12-5, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hypofunction of NMDA receptor-mediated neurotransmission might play a critical role in schizophrenia. Sarcosine, N- methylglycine and inhibitor of the glycine transporter-1 (Gly-T1), has been suggested as a novel treatment for schizophrenia. METHODS: Open label sarcosine was added to 22 stabilized patients: 5 patients received 2 gm/d, and 17 received 4gm/d. Pharmacokinetics samples, clinical and cognitive parameters using PANSS, CGI and MCCB were collected for all patients. RESULTS: Significant improvement was observed after one week of treatment on PANSS sub-scale of 'positive symptoms' (Z= -2.68; P=0.007) and 'general psychopathology' (Z= -3.02; P=0.003), an improvement in PANSS total score and CGI-S showed a trend (Z= -2.72; P=0.06; Z=-2.69; P=0.08). Speed of processing (MCCB subscale) improved significantly (Z=-2.13; P=0.03). Sarcosine exhibited linear kinetics, with a Tmax and t½ of ~1½- 2½ hr and ~1hr, respectively. LIMITATIONS: This was a short period, open label pilot study with small sample size per dosage group. CONCLUSIONS: Sarcosine is a safe compound and might be efficacious in the treatment of schizophrenia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 4118595 MEDLINE  
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[PMID]: 25841104
[Au] Autor:Levental U; Bersudsky Y; Dwalatzky T; Lerner V; Medina S; Levine J
[Ad] Address:Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel....
[Ti] Title:A pilot open study of long term high dose creatine augmentation in patients with treatment resistant negative symptoms schizophrenia.
[So] Source:Isr J Psychiatry Relat Sci;52(1):6-10, 2015.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: The effects of creatine on brain metabolism and the potential cognitive enhancing properties of this compound raise the possibility of developing a new augmentation therapeutic strategy in schizophrenia especially in patients demonstrating negative and cognitive symptomatology. METHODS: Seven inpatients with chronic schizophrenia presenting with treatment resistant negative symptoms were enrolled into exploratory treatment study with creatine monohydrate augmentation at a daily high-dose of 10 grams, administered for 6 months. Several clinical rating scales and a computerized cognitive assessment battery were applied. RESULTS: Creatine treatment mildly improved the schizophrenia symptomatology but there were no significant changes in cognitive functions. Several ward behaviors were also improved. Tardive parkinsonism improved numerically by above 40% in 4 out of 6 patients. CONCLUSION: This small, open design study of high dose creatine add-on for 6 months in chronic inpatients with schizophrenia demonstrated only mild positive effects on the patients' symptomatology and behavior and might have beneficial effect on tardive parkinsonism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 4118595 MEDLINE  
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[PMID]: 25841230
[Au] Autor:G Lerner A; Goodman C; Rudinski D; Lev-Ran S
[Ad] Address:Lev Hasharon Mental Health Medical Center, Pardessya, Israel Sackler School Of Medicine, Tel Aviv University, Ramat Aviv, Israel....
[Ti] Title:LSD Flashbacks - The Appearance of New Visual Imagery Not Experienced During Initial Intoxication: Two Case Reports.
[So] Source:Isr J Psychiatry Relat Sci;51(4):307-9, 2014.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:A side effect associated with the use of synthetic hallucinogens such as lysergic acid diethylamide-(LSD) is the partial or total recurrence of perceptual disturbances which previously appeared during intoxication, despite absence of recent use. These are commonly referred to as "flashbacks" or Hallucinogen Persisting Perception Disorder (HPPD). Here we present two cases of patients with a prior history of LSD use who turned to psychiatric consultation following brief episodes of HPPD. Surprisingly, in both cases new visual imagery appeared during episodes of flashbacks which was not experienced during primary LSD use. Both subjects reported the ability to discern between LSD-associated visual disturbances and new visual imagery. This phenomenon did not cause functional impairment and in both cases caused gradual concern due to its persistence. Both patients refused medical treatment and continued psychiatric follow-up. At one year follow-up both patients reported almost complete spontaneous remission. To the best of our knowledge these are the first reported cases of LSD-related benign flashbacks in which new imagery is experienced. Reasons for this reversible and apparently harmless side effect are proposed. Conclusions from case reports should be taken with caution.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 4118595 MEDLINE  
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[PMID]: 25841229
[Au] Autor:Malnick S; Sheidvasser V; Basevitz A; Levit S
[Ad] Address:Kaplan Medical Center, Rehovot, Israel....
[Ti] Title:A model for treating HCV hepatitis in patients receiving methadone maintenance therapy.
[So] Source:Isr J Psychiatry Relat Sci;51(4):303-5, 2014.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Although hepatitis C virus (HCV) is associated with substance abuse, treatment of addicts is problematic. We report the results of a pilot scheme for treatment of HCV - infected substance abusers in a methadone maintenance center (MMC). METHODS: The treatment program was carried out at a single MMC. Patients were not using illicit drugs or alcohol and received regular treatment with methadone. The program consisted of 5 stages: 1. An explanatory lecture concerning HCV (50/114 attended). 2. 25 of the 50 presented for examination including HCV RNA, genotype and viral load. 3. HCV treatment with pegylated alfa-interferon-1b and ribavarin. 4. The MMC physician and staff aided the clients' medical compliance. 5. A hepatologist (SM) volunteered his services on the basis of one 3 hourly session every 4-6 weeks, in addition to open access telephone consultation with the MMC staff physician. RESULTS: 50 of 114 HCV seropositive clients attended the initial meeting , 25 (50%) were candidates for treatment, of whom 20 were treated. 10 had genotype 3 infection, 9 genotype 1 and 1 genotype 2. The sustained virological response (SVR) on an intention-to-treat basis was 8/20 (40%). DISCUSSION: We present a model for the successful treatment of chronic HCV hepatitis in patients receiving methadone.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 4118595 MEDLINE  
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[PMID]: 25841227
[Au] Autor:Delayahu Y; Nehama Y; Sagi A; Baruch Y; M Blass D
[Ad] Address:Abarbanel Mental Health Center, Bat Yam, Israel Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel....
[Ti] Title:Evaluating the clinical impact of involuntary admission to a specialized dual diagnosis ward.
[So] Source:Isr J Psychiatry Relat Sci;51(4):290-5, 2014.
[Is] ISSN:0333-7308
[Cp] Country of publication:Israel
[La] Language:eng
[Ab] Abstract:BACKGROUND: We aimed to identify characteristics and outcomes of involuntary and voluntary admissions of dual-diagnosis patients in a single, large mental health center in Israel. METHODS: Using a retrospective chart review methodology, 24 patient records were reviewed spanning a period of five years; clinical and demographic variables of voluntary and involuntary admissions were compared. RESULTS: No significant differences were found in sociodemographic characteristics, admission diagnosis and length of hospitalization between the two types of admission. A smaller proportion of patients discharged from involuntary admissions were in remission compared to those discharged from voluntary admission. Nevertheless, involuntary admissions were associated with longer time to next hospitalization. LIMITATIONS: The data were based on a small number of patients in a single ward, thus the generalizability of the results is uncertain. CONCLUSIONS: The finding of the current study that involuntary admission leads to longer tenure in the community suggests that there may be clinical advantages to involuntary admissions for certain dual diagnosis patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review


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