Database : MEDLINE
Search on : Patients [Words]
References found : 4147458 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 414746 go to page                         

  1 / 4147458 MEDLINE  
              next record last record
select
to print
Photocopy

[PMID]: 25957430
[Au] Autor:Hallajzadeh J; Ghorbanihaghjo A; Argani H; Dastmalchi S; Rashtchizadeh N
[Ti] Title:Growth Arrest-specific 6 Protein and Matrix Gla Protein in Hemodialysis Patients.
[So] Source:Iran J Kidney Dis;9(3):249-55, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Plasma protein growth arrest-specific 6 (GAS6) and matrix Gla protein (MGP) are crucial mediators of vascular calcification and are involved in the development of vascular complications in chronic kidney diseases. This study was set out to investigate the relationship between plasma GAS6 levels and MGP in patients with end-stage renal disease on maintenance hemodialysis. MATERIALS AND METHODS: Forty-six hemodialysis and 46 healthy individuals with normal kidneys were recruited. Plasma GAS6 and MGP concentrations and related biochemical factors were quantified as well as collection of data on clinical characteristics. RESULTS: Plasma GAS6 levels were significantly higher in the hemodialysis patients as compared with the control group (763.52 ± 187.91 pg/mL versus 421.63 ± 189.91 pg/mL, P < .001). Plasma MGP concentration was significantly lower in the hemodialysis patients than the control group (52.35 ± 12.35 ng/mL versus 6.60 ± 19.54 ng/mL, P < .001). The levels of GAS6 were inversely associated with MGP (r = -0.341, P = .02) in the hemodialysis patients. CONCLUSIONS: Increased GAS6 and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification, and their inverse correlation may suggest that there might be a role in increased calcification process in hemodialysis patients or only as a secondary phenomenon of advanced kidney failure. Their direct role on vascular calcification needs further studies in the future.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 25957429
[Au] Autor:Samavat S; Kalantari S; Nafar M; Rutishauser D; Rezaei-Tavirani M; Parvin M; Zubarev RA
[Ti] Title:Diagnostic urinary proteome profile for immunoglobulin a nephropathy.
[So] Source:Iran J Kidney Dis;9(3):239-48, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Immunoglobulin A (IgA) nephropathy, the most common type of glomerulonephritis, is only diagnosed by invasive kidney biopsy. Urine proteome panel might help in noninvasive diagnosis and also better understanding of pathogenesis of IgA nephropathy. MATERIALS AND METHODS: Second mid-stream urine samples of 13 patients with biopsy-proven IgA nephropathy and 8 healthy controls were investigated by means of nanoscale liquid chromatography tandem mass spectrometry. Multivariate analysis of quantified label-free proteins was performed by the principal component analysis and partial least squares models. RESULTS: A total number of 493 unique proteins were quantified by nanoscale liquid chromatography tandem mass spectrometry, of which 46 proteins were considered as putative biomarkers of IgA nephropathy, after multivariate analysis and additional filter criterion and comparing the patients and the controls. Some of the significant differentially expressed proteins were CD44, glycoprotein 2, vasorin, epidermal growth factor, CLM9, protocadherin, utreoglobin, dipeptidyl peptidase IV, NHL repeat-containing protein 3, and SLAM family member 5. These proteins were related to various involved pathogenic pathways of inflammatory response and complement system. CONCLUSIONS: This proteome profile could be utilized in the diagnosis of IgA nephropathy. In addition, providing a noninvasive diagnostic tool, it may shed light on the pathogenesis of IgA nephropathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 25957428
[Au] Autor:Hooman N; Otukesh H; Fazilaty H; Torktaz I; Hosseini R; Behnam B
[Ti] Title:A novel mutation pattern of kidney anion exchanger 1 gene in patients with distal renal tubular acidosis in iran.
[So] Source:Iran J Kidney Dis;9(3):230-8, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Mutations of the anion exchanger 1 (AE1) gene encoding the kidney anion exchanger 1 can result in autosomal dominant or autosomal recessive form of distal renal tubular acidosis (DRTA). This study aimed to report deletion mutations of the AE1 and its impact on Iranian children with DRTA. MATERIALS AND METHODS: Twelve children with DRTA referred to Ali Asghar Children Hospital were investigated for all AE1 gene exons through polymerase chain reaction amplification, DNA sequencing, and bioinformatics analysis. RESULTS: Eleven of 12 patients (91.7%) showed an alteration in AE1 gene with a real hot spot in its exons 11 or 15. Homozygote and heterozygote deletions were confirmed in exon 15 in 5 (41.7%) and 3 (25.0%), respectively. Two patients (16.7%) showed homozygote deletions in exon 11 of AE1 gene, and 1 patient (8.3%) showed point mutation in exon 11. The 3-dimensional structures of the native and these mutant kidney AE1 proteins were determined by the multitemplate method using the Phyre and Hidden Markov Model algorithms. CONCLUSIONS: Parents' consanguinity of these patients reveals that cousins are at a high risk for DRTA. This study is considered as a pilot study showing the importance of AE1 mutations in Iranian children with DRTA and further studies is recommended in this geographic region of the world. These models suggest that alteration in the structures leads to alteration in function and change in the current role of AE1.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 25957425
[Au] Autor:Yilmaz M; Sari I; Bagci B; Gumus E; Ozdemir O
[Ad] Address:Department of Research Centre, Cumhuriyet University, School of Medicine, Sivas, Turkey. meralylmz@gmail.com.
[Ti] Title:Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
[So] Source:Iran J Kidney Dis;9(3):209-14, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:INTRODUCTION: It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344 C>T polymorphism on the development of CKD in a Turkish population. MATERIAL AND METHODS: A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T>C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. RESULTS: No significant differences were found in the genotype distribution of CYP11B2 -344 C>T polymorphism between the patients and controls; however, -344 C>T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P = .02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67). CONCLUSIONS: Our study suggests that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 25957421
[Au] Autor:Barahimi H; Abolhassani F; Rajaee F; Akbari Sari A
[Ad] Address:Tehran University of Medical Sciences, Tehran, Iran. h-barahimi@farabi.tums.ac.ir.
[Ti] Title:A multilevel model for services provided to patients with chronic kidney disease.
[So] Source:Iran J Kidney Dis;9(3):186-92, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:Chronic kidney disease (CKD) is a general health problem with high rates of mortality and morbidity. The increasing prevalence of CKD has led to the recognition of the fact that it needs special care. One approach to CKD management is to present a model of care for the disease. A model of care for CKD was developed by drawing on the literature, including guidelines for CKD care, and by using previous experiences in providing care for patients with diabetes mellitus and CKD. The model focuses on training, identification of patients, care, follow-up, and evaluation of patients. In this study, two levels were defined for providing care to patients with CKD. The first level involves care provided by family physicians, while the second level was defined as community health services for CKD. Establishment of at least 1 CKD community health service at each capital city of any province seems to be an effective factor in improving services provided to patients with CKD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 25957419
[Au] Autor:Modaresi A; Nafar M; Sahraei Z
[Ti] Title:Oxidative stress in chronic kidney disease.
[So] Source:Iran J Kidney Dis;9(3):165-79, 2015 May.
[Is] ISSN:1735-8604
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:Patients with chronic kidney disease (CKD) have high incidence rates of cardiovascular disease and malignancy. Several factors contribute to these conditions. Structural characteristics in CKD, loss of renal energy, and uremia result in an imbalance between free radical production and antioxidant defenses. Also, CKD patients usually have multiple cardiovascular risk factors like diabetes mellitus, dyslipidemia, and hypertension. These conditions are associated with oxidative stress, which can trigger the inflammatory process and accelerate renal injury progression. There are some clinical biomarkers to detect oxidative stress and antioxidant status in CKD patients. Antioxidant therapies may be beneficial in reducing oxidative stress, lowering uremic cardiovascular toxicity, and improving survival. Therefore, their roles in CKD patients have been evaluated in several studies as a new target for therapeutic intervention. This review provides an overview of oxidative stress mechanisms, clinical squeals, biomarkers, and possible antioxidant therapies in CKD patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24871344
[Au] Autor:Menon PR; Stapleton RD; McVeigh U; Rabinowitz T
[Ad] Address:University of Vermont, Burlington, VT, USA Department of Medicine, Pulmonary Critical Care Medicine Division, University of Vermont, Burlington, VT, USA prema.menon@vtmednet.org....
[Ti] Title:Telemedicine as a tool to provide family conferences and palliative care consultations in critically ill patients at rural health care institutions: a pilot study.
[So] Source:Am J Hosp Palliat Care;32(4):448-53, 2015 Jun.
[Is] ISSN:1938-2715
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Many critically ill patients who transfer from rural hospitals to tertiary care centers (TCCs) have poor prognoses, and family members are unable to discuss patient prognosis and goals of care with TCC providers until after transfer. AIM: Our TCC conducted teleconferences prior to transfer to facilitate early family discussions. DESIGN/SETTING: We conducted a retrospective review of these telemedicine family conferences among critically ill patients requested for transfer which occurred from December 2008 to December 2009 at our TCC. Outcomes for each patient and detailed descriptions of the conference content were obtained. We also assessed limitations and attitudes and satisfaction with this intervention among clinicians. RESULTS: During the 12-month period, 12 telemedicine consultations were performed. Of these patients, 10 (83%) died in the 30 days following the request for transfer. After the telemedicine consultation, 8 (67%) patients were transferred to our TCC from their respective hospitals, while 4 (33%) patients continued care at their regional hospital and did not transfer. Of the patients who transferred to TCC, 7 (88% of those transferred) returned to their community after a stay at the TCC. CONCLUSION: This study demonstrates that palliative care consultations can be provided via telemedicine for critically ill patients and that adequate preparation and technical expertise are essential. Although this study is limited by the nature of the retrospective review, it is evident that more research is needed to further assess its applicability, utility, and acceptability.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM; N
[St] Status:In-Data-Review
[do] DOI:10.1177/1049909114537110

  8 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24622867
[Au] Autor:Ushikubo M
[Ad] Address:Gunma University Graduate School of Health Sciences, Maebashi-shi, Gunma, Japan ushi2@gunma-u.ac.jp.
[Ti] Title:Comparison between home and hospital as the place of death for individuals with amyotrophic lateral sclerosis in the last stages of illness.
[So] Source:Am J Hosp Palliat Care;32(4):417-26, 2015 Jun.
[Is] ISSN:1938-2715
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Healthcare providers need to better understand the end-of-life situations of in-home amyotrophic lateral sclerosis (ALS) patients to support their desires about where to die and to allow peaceful death. PURPOSE: To clarify the situations of individuals with ALS in the last stages of illness according to the place of death as reported by home care nurses. METHODS: Minimum structured interviews were conducted with 14 home care nurses, and data regarding 14 ALS patients who died were collected. RESULTS: Six patients died at home, and eight died at the hospital. Many sudden deaths were observed among the patients who died at home, whereas pneumonia was often the cause of death in the hospital. CONCLUSION: Providing family education and ensuring the availability of local family physicians are vital to meeting a patient's desire to die at home. Home care nursing should be introduced in the early stage after diagnosis to provide support to patients for timely decision-making. .
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM; N
[St] Status:In-Data-Review
[do] DOI:10.1177/1049909114525259

  9 / 4147458 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 24619923
[Au] Autor:Chung K; Jahng J; Petrosyan S; Kim SI; Yim V
[Ad] Address:Department of Health Sciences, College of Health and Human Development, California State University, Northridge, CA, USA stephan.chung@csun.edu....
[Ti] Title:Assessment of levels of hospice care coverage offered to commercial managed care plan members in california: implications for the california health insurance exchange.
[So] Source:Am J Hosp Palliat Care;32(4):440-7, 2015 Jun.
[Is] ISSN:1938-2715
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The implementation of the Affordable Care Act that provides for the expansion of affordable insurance to uninsured individuals and small businesses, coupled with the provision of mandated hospice coverage, is expected to increase the enrollment of the terminally ill younger population in hospice care. We surveyed health insurance companies that offer managed care plans in the 2014 California health insurance exchange and large hospice agencies that provided hospice care to privately insured patients in 2011. Compared with Medicare and Medicaid hospice benefits, hospice benefits for privately insured patients, particularly those enrolled in managed care plans, varied widely. Mandating hospice care alone may not be sufficient to ensure that individuals enrolled in different managed care plans receive the same level of coverage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM; N
[St] Status:In-Data-Review
[do] DOI:10.1177/1049909114526298

  10 / 4147458 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 24595322
[Au] Autor:Smith B; McDuff J; Naierman N; Kreling B; Tein N; Hunter D; Deviney M; Lynn J
[Ad] Address:Center for Consumer Choice in Health Care, Altarum Institute, San Antonio, TX, USA paulbradleysmith@gmail.com....
[Ti] Title:What consumers want to know about quality when choosing a hospice provider.
[So] Source:Am J Hosp Palliat Care;32(4):393-400, 2015 Jun.
[Is] ISSN:1938-2715
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Despite the availability of endorsed quality measures and widespread usage of hospice, hospice quality data are rarely available to consumers. Moreover, little is known about how consumers prioritize extant measures. This study drew on focus group and survey data collected in 5 metropolitan areas. The study found that consumers reported the hospice quality indicators we tested were easy to understand. Participants placed top priority on measures related to pain and symptom management. Relative to consumers with hospice experience, consumers without previous experience tended to place less value on spiritual support for patients and caregivers, emotional support for caregivers, and after-hours availability. The National Quality Forum-approved measures resonate well with consumers. Consumers also appear to be ready for access to data on the quality of hospice providers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Js] Journal subset:IM; N
[St] Status:In-Data-Review
[do] DOI:10.1177/1049909114524475


page 1 of 414746 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information