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[PMID]: 29281664
[Au] Autor:Strutzenberger P; Brehm G; Gottsberger B; Bodner F; Seifert CL; Fiedler K
[Ad] Address:Department of Botany and Biodiversity Research, Division of Tropical Ecology and Animal Biodiversity, University of Vienna, Vienna, Austria.
[Ti] Title:Diversification rates, host plant shifts and an updated molecular phylogeny of Andean Eois moths (Lepidoptera: Geometridae).
[So] Source:PLoS One;12(12):e0188430, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eois is one of the best-investigated genera of tropical moths. Its close association with Piper plants has inspired numerous studies on life histories, phylogeny and evolutionary biology. This study provides an updated view on phylogeny, host plant use and temporal patterns of speciation in Eois. Using sequence data (2776 bp) from one mitochondrial (COI) and one nuclear gene (Ef1-alpha) for 221 Eois species, we confirm and reinforce previous findings regarding temporal patterns of diversification. Deep diversification within Andean Eois took place in the Miocene followed by a sustained high rate of diversification until the Pleistocene when a pronounced slowdown of speciation is evident. In South America, Eois diversification is very likely to be primarily driven by the Andean uplift which occurred concurrently with the entire evolutionary history of Eois. A massively expanded dataset enabled an in-depth look into the phylogenetic signal contained in host plant usage. This revealed several independent shifts from Piper to other host plant genera and families. Seven shifts to Peperomia, the sister genus of Piper were detected, indicating that the shift to Peperomia was an easy one compared to the singular shifts to the Chloranthaceae, Siparunaceae and the Piperacean genus Manekia. The potential for close co-evolution of Eois with Piper host plants is therefore bound to be limited to smaller subsets within Neotropical Eois instead of a frequently proposed genus-wide co-evolutionary scenario. In regards to Eois systematics we confirm the monophyly of Neotropical Eois in relation to their Old World counterparts. A tentative biogeographical hypothesis is presented suggesting that Eois originated in tropical Asia and subsequently colonized the Neotropics and Africa. Within Neotropical Eois we were able to identify the existence of six clades not recognized in previous studies and confirm and reinforce the monophyly of all 9 previously delimited infrageneric clades.
[Mh] MeSH terms primary: Moths/classification
Phylogeny
Plants
[Mh] MeSH terms secundary: Animals
DNA/genetics
Electron Transport Complex IV/genetics
Moths/genetics
South America
Species Specificity
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:9007-49-2 (DNA); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Js] Journal subset:IM
[Da] Date of entry for processing:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188430

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[PMID]: 29142389
[Au] Autor:Okoh SO; Iweriebor BC; Okoh OO; Okoh AI
[Ad] Address:SAMRC Microbial Water Quality Monitoring Centre, Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Mail Bag X1314 Alice 5700, Eastern Cape, South Africa.
[Ti] Title:Bioactive Constituents, Radical Scavenging, and Antibacterial Properties of the Leaves and Stem Essential Oils from (L.) Kunth.
[So] Source:Pharmacogn Mag;13(Suppl 3):S392-S400, 2017 Oct.
[Is] ISSN:0973-1296
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Background: is an annual herbaceous ethnomedicinal plant used in the treatment of a variety of communicable and noncommunicable diseases in the Amazon region. Objective: The study aimed at profiling the bioactive constituents of the leaves and stem essential oils (LEO and SEO) of , their antibacterial and radical scavenging properties as probable lead constituents in the management of oxidative stress and infectious diseases. Materials and. Methods: The EOs were obtained from the leaves and stem using modified Clevenger apparatus and characterized by a high-resolution gas chromatography-mass spectrometry, while the radicals scavenging and antibacterial effects on four oxidants and six reference bacteria strains were examined by spectrophotometric and agar diffusion techniques, respectively. Results: The EOs exhibited strong antibacterial activities against six bacteria ( [180], , , and ) strains. The SEO antibacterial activities were not significantly different ( < 0.05) from the LEO against most of the test bacteria with minimum inhibitory concentration ranging between 0.15 and 0.20 mg/mL for both EOs. The two oils were bactericidal at 0.20 mg/mL against while the minimum bactericidal concentration (0.15 mg/mL) of LEO against was lower than of SEO (0.20 mg/mL) after 24 h. The LEO IC value (1.67 mg/mL) revealed more radical scavenging activity than the SEO (2.83 mg/mL) and reference compounds against 2,2-diphenyl-1-picrylhydrazyl radical. The EOs also scavenged three other different radicals (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical, lipid peroxyl radical, and nitric oxide radical) in concentration-dependent manner. Conclusion: Our results suggest that apart from the indigenous uses of the plant extracts, the EO contains strong bioactive compounds with antibacterial and radicals scavenging properties and may be good alternative candidates in the search for novel potent antibiotics in this present era of increasing multidrug-resistant bacterial strains as well as effective antioxidants agents. SUMMARY: Established gas chromatography-mass spectrometry technique was applied to quantitatively and qualitatively analyze the volatile constituents in essential oil (EO)The Clinical and Laboratory Standards Institute (2014) guidelines were employed to evaluate the antibacterial effects of the EOsAmong the known prominent bioactive terpenoids, linalool 17.09%, limonene 14.25%, ß-caryophyllene 12.52%, and linalyl acetate 10.15% were the main constituents of the EOs in this current studyThe leaf and stem EOs were bactericidal at a concentration below 0.23 mg/mL against three multidrug-resistant bacteria and significantly scavenged known free radicals reported to be associated with contagious and oxidative stress-related disorders. GC-MS: Gas chromatography-mass spectrometry, DPPH: 2,2-diphenyl-1-picrylhydrazyl, ABTS: 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, DMSO: Dimethyl sulfoxide, LP : Lipid peroxide radical, NO : Nitric oxide radical, LEO: Leaf essential oil, SEO: Stem essential oil, RC: Reference compound, TBARS: Thiobarbituric acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171119
[Lr] Last revision date:171119
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/pm.pm_106_17

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Romoff, Paulete
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[PMID]: 28906474
[Au] Autor:Tamayose CI; Romoff P; Toyama DO; Gaeta HH; Costa CRC; Belchor MN; Ortolan BD; Velozo LSM; Kaplan MAC; Ferreira MJP; Toyama MH
[Ad] Address:Curso de Química, Universidade Presbiteriana Mackenzie, Rua da Consolação, São Paulo 01302-907, Brazil. cinthiatamay@gmail.com.
[Ti] Title:Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema.
[So] Source:Int J Mol Sci;18(9), 2017 Sep 14.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Compound 8- -rhamnosyl apigenin (8CR) induced a moderate reduction in the enzymatic activity of secretory phospholipase A2 (sPLA2) from and cytosolic phospholipase A2 (cPLA2), but the compound also significantly inhibited the enzymatic activity of the enzyme cyclooxygenase. In vitro assays showed that the compound induced a slight change in the secondary structure of sPLA2 from snake venom. In vivo assays were divided into two steps. In the first step, the 8CR compound was administered by intraperitoneal injections 30 min prior to administration of sPLA2. In this condition, 8CR inhibited edema and myonecrosis induced by the sPLA2 activity of in a dose-dependent manner by decreasing interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), and lipid peroxidation. This has been demonstrated by monitoring the levels of malondialdehyde (MDA) in rat paws after the course of edema induced by sPLA2. These results, for the first time, show that sPLA2 of venom induces massive muscle damage, as well as significant edema by mobilization of cyclooxygenase enzymes. Additionally, its pharmacological activity involves increased lipid peroxidation as well as TNF-α and IL-1ß production. Previous administration by the peritoneal route has shown that dose-dependent 8CR significantly decreases the enzymatic activity of cyclooxygenase enzymes. This resulted in a decrease of the amount of bioactive lipids involved in inflammation; it also promoted a significant cellular protection against lipid peroxidation. In vivo experiments performed with 8CR at a concentration adjusted to 200 µg (8 mg/kg) of intraperitoneal injection 15 min after sPLA2 injection significantly reduced sPLA2 edema and the myotoxic effect induced by sPLA2 through the decrease in the enzymatic activity of cPLA2, cyclooxygenase, and a massive reduction of lipid peroxidation. These results clearly show that 8CR is a potent anti-inflammatory that inhibits cyclooxygenase-2 (COX-2), and it may modulate the enzymatic activity of sPLA2 and cPLA2. In addition, it was shown that sPLA2 increases cell oxidative stress during edema and myonecrosis, and the antioxidant properties of the polyphenolic compound may be significant in mitigating the pharmacological effect induced by sPLA2 and other snake venom toxins.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:In-Process

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[PMID]: 28859930
[Au] Autor:Sun RF; Zhu CC; Yang Y; Yu NJ
[Ad] Address:Beijing Institute of Pharmacology and Toxicology, Beijing 100850, People's Republic of China.
[Ti] Title:Novel secolignans from Peperomia dindygulensis and their inhibitory activities on JAK-STAT signaling pathways.
[So] Source:Fitoterapia;122:80-84, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Nineteen secolignans (1-19), including five new ones (1-5), were isolated from the whole plant of Peperomia dindygulensis. Their structures including stereochemistry were determined by spectroscopic methods, in particular NMR and electronic CD (ECD) analysis. All the isolates were evaluated for their inhibitory activities against IFN-γ/STAT1 as well as IL-6/STAT3 signaling pathway by the method of Luciferase assay. Six 2-methene type secolignans (1, 2, 6-9) exhibited significant inhibitory activities against JAK-STAT pathways with the IC values both lower than 10µM.
[Mh] MeSH terms primary: Lignans/pharmacology
Peperomia/chemistry
Signal Transduction/drug effects
[Mh] MeSH terms secundary: Hep G2 Cells
Humans
Interleukin-6/metabolism
Molecular Structure
STAT1 Transcription Factor/metabolism
STAT3 Transcription Factor/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (IL6 protein, human); 0 (Interleukin-6); 0 (Lignans); 0 (STAT1 Transcription Factor); 0 (STAT1 protein, human); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human)
[Em] Entry month:1711
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[Js] Journal subset:IM
[Da] Date of entry for processing:170902
[St] Status:MEDLINE

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[PMID]: 28422496
[Au] Autor:Batista ANL; Santos-Pinto JRAD; Batista JM; Souza-Moreira TM; Santoni MM; Zanelli CF; Kato MJ; López SN; Palma MS; Furlan M
[Ad] Address:Instituto de Química, Universidade Estadual Paulista (Unesp) , Araraquara, SP 14800-060, Brazil.
[Ti] Title:The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia.
[So] Source:J Nat Prod;80(5):1275-1286, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Peperomia obtusifolia, an ornamental plant from the Piperaceae family, accumulates a series of secondary metabolites with interesting biological properties. From a biosynthesis standpoint, this species produces several benzopyrans derived from orsellinic acid, which is a polyketide typically found in fungi. Additionally, the chiral benzopyrans were reported as racemic and/or as diastereomeric mixtures, which raises questions about the level of enzymatic control in the cyclization step for the formation of the 3,4-dihydro-2H-pyran moiety. Therefore, this article describes the use of shotgun proteomic and transcriptome studies as well as phytochemical profiling for the characterization of the main biosynthesis pathways active in P. obtusifolia. This combined approach resulted in the identification of a series of proteins involved in its secondary metabolism, including tocopherol cyclase and prenyltransferases. The activity of these enzymes was supported by the phytochemical profiling performed in different organs of P. obtusifolia. However, the polyketide synthases possibly involved in the production of orsellinic acid could not be identified, suggesting that orsellinic acid may be produced by endophytes intimately associated with the plant.
[Mh] MeSH terms primary: Benzopyrans/chemistry
Endophytes/chemistry
Fungi/chemistry
Peperomia/chemistry
Plant Leaves/chemistry
Polyketide Synthases/metabolism
Resorcinols/chemistry
Transcriptome/genetics
[Mh] MeSH terms secundary: Biosynthetic Pathways
Endophytes/metabolism
Fungi/metabolism
Molecular Structure
Polyketide Synthases/chemistry
Proteomics/methods
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Benzopyrans); 0 (Resorcinols); 11XLA0494B (orsellinic acid); 79956-01-7 (Polyketide Synthases)
[Em] Entry month:1709
[Cu] Class update date: 170925
[Lr] Last revision date:170925
[Js] Journal subset:IM
[Da] Date of entry for processing:170420
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00827

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[PMID]: 28372562
[Au] Autor:Florence NT; Huguette ST; Hubert DJ; Raceline GK; Desire DD; Pierre K; Theophile D
[Ad] Address:Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde1, P.O. Box 812, Yaounde, Cameroon. tsngueguim@yahoo.fr.
[Ti] Title:Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats.
[So] Source:BMC Complement Altern Med;17(1):188, 2017 Apr 04.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats. METHODS: A drill hole injury was created by inserting a drill bit inthe diaphysis of the femur. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats. The vehicle (distilled water) was given to the control. Besides these rats, one group of rats without fracture received the extract (400 mg/kg). After 14 days of treatment, the rats were sacrificed under anesthesia and the effects of the extract were evaluated on body weight, the relative weights of organs (femurs, uteri and ovaries) and on hematology. Bone (calcium, phosphorus, alkaline phosphatase) and serum biochemical parameters (calcium, phosphorus, alkaline phosphatase) were also evaluated. Radiological and histological tests were carried out on the femurs. The mineral content of the plant extract was also investigated. RESULTS: The extract induced an increase in body weight at high dose and in WBCs count at low doses. Aqueous extract from Peperomia pellucida increased bone calcium at lowest dose but maintained this parameter at normal range at high dose in fractured rat. Alkaline phophatase and phosphorus concentrations reduced significantly (p < 0.01) at the dose of 400 mg/kg as compared to fractured rats. Moreover, radiological tests revealed a dose dependent formation of callus at the level of the fracture gap, confirmed by the formation of a highly dense and compact fibrocartilagenous callus. The mineral content of the plant extract revealed the presence of calcium, phosphorus, magnesium, sodium and potassium. CONCLUSION: The aqueous extract of P. pellucida accelerates bone healing due partly to the mineral content of the extract. These results confirm its traditional use in the treatment of bone fractures.
[Mh] MeSH terms primary: Femoral Fractures/drug therapy
Fracture Healing/drug effects
Peperomia/chemistry
Plant Extracts/administration & dosage
[Mh] MeSH terms secundary: Animals
Female
Femoral Fractures/physiopathology
Femur/drug effects
Femur/injuries
Humans
Plant Extracts/chemistry
Rats
Rats, Wistar
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Plant Extracts)
[Em] Entry month:1704
[Cu] Class update date: 170417
[Lr] Last revision date:170417
[Js] Journal subset:IM
[Da] Date of entry for processing:170405
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1686-3

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[PMID]: 28273402
[Au] Autor:Dorla E; Gauvin-Bialecki A; Deuscher Z; Allibert A; Grondin I; Deguine JP; Laurent P
[Ad] Address:Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion, Avenue René Cassin-CS, 92003-97744, Saint-Denis Cedex 9, France.
[Ti] Title:Insecticidal Activity of the Leaf Essential Oil of Peperomia borbonensis Miq. (Piperaceae) and Its Major Components against the Melon Fly Bactrocera cucurbitae (Diptera: Tephritidae).
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The essential oil from the leaves of Peperomia borbonensis from Réunion Island was obtained by hydrodistillation and characterized using GC-FID, GC/MS and NMR. The main components were myristicin (39.5%) and elemicin (26.6%). The essential oil (EO) of Peperomia borbonensis and its major compounds (myristicin and elemicin), pure or in a mixture, were evaluated for their insecticidal activity against Bactrocera cucurbitae (Diptera: Tephritidae) using a filter paper impregnated bioassay. The concentrations necessary to kill 50% (LC ) and 90% (LC ) of the flies in three hours were determined. The LC value was 0.23 ± 0.009 mg/cm and the LC value was 0.34 ± 0.015 mg/cm for the EO. The median lethal time (LT ) was determined to compare the toxicity of EO and the major constituents. The EO was the most potent insecticide (LT  = 98 ± 2 min), followed by the mixture of myristicin and elemicin (1.4:1) (LT  = 127 ± 2 min) indicating that the efficiency of the EO is potentiated by minor compounds and emphasizing one of the major assets of EOs against pure molecules.
[Mh] MeSH terms primary: Insecticides/isolation & purification
Oils, Volatile/chemistry
Peperomia/chemistry
Plant Leaves/chemistry
Tephritidae/drug effects
[Mh] MeSH terms secundary: Animals
Benzyl Compounds/isolation & purification
Benzyl Compounds/toxicity
Dioxolanes/isolation & purification
Dioxolanes/toxicity
Diptera/drug effects
Gas Chromatography-Mass Spectrometry
Insecticides/pharmacology
Magnetic Resonance Spectroscopy
Pyrogallol/analogs & derivatives
Pyrogallol/isolation & purification
Pyrogallol/toxicity
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Benzyl Compounds); 0 (Dioxolanes); 0 (Insecticides); 0 (Oils, Volatile); 01Y4A2QXY0 (Pyrogallol); 04PD6CT78W (myristicin); 487-11-6 (elemicin)
[Em] Entry month:1708
[Cu] Class update date: 170822
[Lr] Last revision date:170822
[Js] Journal subset:IM
[Da] Date of entry for processing:170309
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600493

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[PMID]: 28179114
[Au] Autor:Giovannini P; Howes MR
[Ad] Address:Natural Capital and Plant Health Department, Royal Botanic Gardens Kew, Wakehurst Place, Ardingly, West Sussex RH17 6TN, UK. Electronic address: P.Giovannini@kew.org.
[Ti] Title:Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence.
[So] Source:J Ethnopharmacol;199:240-256, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Every year between 1.2 and 5.5 million people worldwide are victims of snakebites, with about 400,000 left permanently injured. In Central America an estimated 5500 snakebite cases are reported by health centres, but this is likely to be an underestimate due to unreported cases in rural regions. The aim of this study is to review the medicinal plants used traditionally to treat snakebites in seven Central American countries: Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama. MATERIALS AND METHODS: A literature search was performed on published primary data on medicinal plants of Central America and those specifically pertaining to use against snakebites. Plant use reports for traditional snakebite remedies identified in primary sources were extracted and entered in a database, with data analysed in terms of the most frequent numbers of use reports. The scientific evidence that might support the local uses of the most frequently reported species was also examined. RESULTS: A total of 260 independent plant use reports were recorded in the 34 sources included in this review, encompassing 208 species used to treat snakebite in Central America. Only nine species were reported in at least three studies: Cissampelos pareira L., Piper amalago L., Aristolochia trilobata L., Sansevieria hyacinthoides (L.) Druce, Strychnos panamensis Seem., Dorstenia contrajerva L., Scoparia dulcis L., Hamelia patens Jacq., and Simaba cedron Planch. Genera with the highest number of species used to treat snakebite were Piper, Aristolochia, Hamelia, Ipomoea, Passiflora and Peperomia. The extent of the scientific evidence available to understand any pharmacological basis for their use against snakebites varied between different plant species. CONCLUSION: At least 208 plant species are traditionally used to treat snakebite in Central America but there is a lack of clinical research to evaluate their efficacy and safety. Available pharmacological data suggest different plant species may target different symptoms of snakebites, such as pain or anxiety, although more studies are needed to further evaluate the scientific basis for their use.
[Mh] MeSH terms primary: Medicine, Traditional/methods
Plant Extracts/therapeutic use
Plants, Medicinal
Snake Bites/drug therapy
Snake Bites/ethnology
[Mh] MeSH terms secundary: Animals
Central America/ethnology
Humans
Plant Extracts/isolation & purification
Plant Preparations/isolation & purification
Plant Preparations/therapeutic use
Snake Bites/diagnosis
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Plant Extracts); 0 (Plant Preparations)
[Em] Entry month:1707
[Cu] Class update date: 170714
[Lr] Last revision date:170714
[Js] Journal subset:IM
[Da] Date of entry for processing:170210
[St] Status:MEDLINE

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[PMID]: 28060996
[Au] Autor:Wang XZ; Wen HM; Chai C; Zhang WY; Gao M; Liu R; Wu H; Liang JY
[Ad] Address:College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
[Ti] Title:Determination of a natural DNMT1 inhibitor, peperomin E, in rat plasma by UFLC-MS/MS and method application in a pharmacokinetic study.
[So] Source:Biomed Chromatogr;31(8), 2017 Aug.
[Is] ISSN:1099-0801
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Peperomin E (PepE), a naturally occurring secolignan isolated from Peperomia dindygulensis, has drawn much attention recently owing to its anticancer and DNA methyltransferase 1 (DNMT1) inhibitory activity. Here, a simple and sensitive ultra-fast liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of PepE in rat plasma for the first time. Samples were prepared by simple protein precipitation. Separation was performed on an XBridge™ C column using a mobile phase of acetonitrile and 0.1% (v/v) aqueous formic acid. PepE and the internal standard arctigenin were detected in a positive-ion mode using multiple reaction monitoring of the transitions at m/z 413.2 → 261.0 and 373.2 → 137.2, respectively. The calibration curve for PepE was linear over the range of concentrations of 1.46-6000 ng/mL, with a lower limit of quantitation of 1.46 ng/mL. Both intra- and interday precisions were within 11.05%, and the accuracy ranged from -11.5 to 5.51%. The extraction recovery and matrix effect were within acceptable limits. Stability tests showed that PepE remained stable throughout the analytical procedure. The validated method was then used to analyze the pharmacokinetics of PepE administered to rats orally (12.5 and 25 mg/kg) or intravenously (6.25 and 12.5 mg/kg).
[Mh] MeSH terms primary: Benzodioxoles/blood
Chromatography, High Pressure Liquid/methods
DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors
Enzyme Inhibitors/blood
Tandem Mass Spectrometry/methods
[Mh] MeSH terms secundary: Administration, Oral
Animals
Benzodioxoles/administration & dosage
Benzodioxoles/analysis
DNA (Cytosine-5-)-Methyltransferase 1
Enzyme Inhibitors/administration & dosage
Enzyme Inhibitors/analysis
Limit of Detection
Male
Peperomia/chemistry
Rats
Rats, Sprague-Dawley
[Pt] Publication type:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Name of substance:0 (Benzodioxoles); 0 (Enzyme Inhibitors); 0 (peperomin E); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases); EC 2.1.1.37 (Dnmt1 protein, rat)
[Em] Entry month:1707
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170107
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3930

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[PMID]: 27561759
[Au] Autor:Vásquez-Ocmín P; Haddad M; Gadea A; Jullian V; Castillo D; Paloque L; Cerapio JP; Bourdy G; Sauvain M
[Ad] Address:a Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
[Ti] Title:A new phthalide derivative from Peperomia nivalis.
[So] Source:Nat Prod Res;31(2):138-142, 2017 Jan.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D ( H and C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1-3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 µM) and the F32-Tanzania strain of P. falciparum (IC 8.5 µM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 µM, respectively) and were inactive against P. falciparum.
[Mh] MeSH terms primary: Benzofurans/chemistry
Benzofurans/pharmacology
Peperomia/chemistry
[Mh] MeSH terms secundary: Animals
Anti-Bacterial Agents/chemistry
Anti-Bacterial Agents/pharmacology
Antimalarials/chemistry
Antimalarials/pharmacology
Helicobacter pylori/drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Peru
Plasmodium falciparum/drug effects
Spectrophotometry, Ultraviolet
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antimalarials); 0 (Benzofurans); 8VV922U86J (phthalide)
[Em] Entry month:1705
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160827
[St] Status:MEDLINE


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