Database : MEDLINE
Search on : Periapical and Diseases [Words]
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Aguiar, Maria Cássia Ferreira
SciELO Brazil full text

[PMID]: 29267664
[Au] Autor:Naufel AO; Aguiar MCF; Madeira FM; Abreu LG
[Ad] Address:Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
[Ti] Title:Treg and Th17 cells in inflammatory periapical disease: a systematic review.
[So] Source:Braz Oral Res;31:e103, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.
[Mh] MeSH terms primary: Periapical Periodontitis/pathology
T-Lymphocytes, Regulatory/pathology
Th17 Cells/pathology
[Mh] MeSH terms secundary: Chronic Disease
Cytokines/analysis
Disease Progression
Forkhead Transcription Factors/analysis
Humans
Periapical Periodontitis/immunology
Publication Bias
T-Lymphocytes, Regulatory/immunology
Th17 Cells/immunology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Cytokines); 0 (FOXP3 protein, human); 0 (Forkhead Transcription Factors)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:D; IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE

  2 / 4164 MEDLINE  
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[PMID]: 29502358
[Au] Autor:Feng Z; Li Q; Meng R; Yi B; Xu Q
[Ad] Address:Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
[Ti] Title:METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
[So] Source:J Cell Mol Med;, 2018 Mar 04.
[Is] ISSN:1582-4934
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Dental pulp inflammation is a widespread public health problem caused by oral bacterial infections and can progress to pulp necrosis and periapical diseases. N6-methyladenosine (m6A) is a prevalent epitranscriptomic modification in mRNA. Previous studies have demonstrated that m6A methylation plays important roles in cell differentiation, embryonic development and stress responses. However, whether m6A modification affects dental pulp inflammation remains unknown. To address this issue, we investigated the expression of m6A and N6-adenosine methyltransferase (METTL3, METTL14) as well as demethylases (FTO, ALKBH5) and found that the levels of m6A and METTL3 were up-regulated in human dental pulp cells (HDPCs) stimulated by lipopolysaccharide (LPS). Furthermore, we knocked down METTL3 and demonstrated that METTL3 depletion decreased the expression of inflammatory cytokines and the phosphorylation of IKKα/ß, p65 and IκBα in the NF-κB signalling pathway as well as p38, ERK and JNK in the MAPK signalling pathway in LPS-induced HDPCs. The RNA sequencing analysis revealed that the vast number of genes affected by METTL3 depletion was associated with the inflammatory response. Previous research has shown that METTL3-dependent N6-adenosine methylation plays an important role in mRNA splicing. In this study, we found that METTL3 knockdown facilitated the expression of MyD88S, a splice variant of MyD88 that inhibits inflammatory cytokine production, suggesting that METTL3 might inhibit the LPS-induced inflammatory response of HDPCs by regulating alternative splicing of MyD88. These data shed light on new findings in epitranscriptomic regulation of the inflammatory response and open new avenues for research into the molecular mechanisms of dental pulp inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher
[do] DOI:10.1111/jcmm.13491

  3 / 4164 MEDLINE  
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[PMID]: 29499125
[Au] Autor:Francisconi CF; Vieira AE; Azevedo MCS; Tabanez AP; Fonseca AC; Trombone APF; Letra A; Silva RM; Sfeir CS; Little SR; Garlet GP
[Ad] Address:1 Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo, Bauru, Brazil.
[Ti] Title:RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis.
[So] Source:J Dent Res;:22034518759302, 2018 Mar 01.
[Is] ISSN:1544-0591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The chronic inflammatory immune response triggered by the infection of the tooth root canal system results in the local upregulation of RANKL, resulting in periapical bone loss. While RANKL has a well-characterized role in the control of bone homeostasis/pathology, it can play important roles in the regulation of the immune system, although its possible immunoregulatory role in infectious inflammatory osteolytic conditions remains largely unknown. Here, we used a mouse model of infectious inflammatory periapical lesions subjected to continuous or transitory anti-RANKL inhibition, followed by the analysis of lesion outcome and multiple host response parameters. Anti-RANKL administration resulted in arrest of bone loss but interfered in the natural immunoregulation of the lesions observed in the untreated group. RANKL inhibition resulted in an unremitting proinflammatory response, persistent high proinflammatory and effector CD4 response, decreased regulatory T-cell (Treg) migration, and lower levels of Treg-related cytokines IL-10 and TGFb. Anti-RANKL blockade impaired the immunoregulatory process only in early disease stages, while the late administration of anti-RANKL did not interfere with the stablished immunoregulation. The impaired immunoregulation due to RANKL inhibition is characterized by increased delayed-type hypersensitivity in vivo and T-cell proliferation in vitro to the infecting bacteria, which mimic the effects of Treg inhibition, reinforcing a possible influence of RANKL on Treg-mediated suppressive response. The adoptive transfer of CD4+FOXp3+ Tregs to mice receiving anti-RANKL therapy restored the immunoregulatory capacity, attenuating the inflammatory response in the lesions, reestablishing normal T-cell response in vivo and in vitro, and preventing lesion relapse upon anti-RANKL therapy cessation. Therefore, while RANKL inhibition efficiently limited the periapical bone loss, it promoted an unremitting host inflammatory response by interfering with Treg activity, suggesting that this classic osteoclastogenic mediator plays a role in immunoregulation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1177/0022034518759302

  4 / 4164 MEDLINE  
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[PMID]: 29480630
[Au] Autor:Shah A; Lee D; Song M; Kim S; Kang MK; Kim RH
[Ad] Address:The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.
[Ti] Title:Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice.
[So] Source:Oral Dis;24(1-2):57-62, 2018 Mar.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Clastic cells, originating from the monocyte-macrophage lineage, resorb mineralized tissues. In periapical periodontitis, alveolar bone around the tooth apex becomes resorbed; however, the roots of the teeth are often left intact by yet unknown mechanisms. Here, we examined the status of clastic cells in a periapical periodontitis model in mice. METHODS: Periapical periodontitis was induced by performing pulp exposure on the maxillary first molar. The contralateral maxillary first molar was used as a control. The maxillae were harvested, fixed, and subjected to µCT scanning and three-dimensional volumetric analysis. TRAP staining was performed, and osteoclasts were quantified. Immunohistochemical staining was performed for RANKL, OPG, and F4/80, a marker for macrophages. RESULTS: At the apex of the tooth, pulp exposure resulted in periapical radiolucency with mineralized tissues at the surrounding bone surfaces but not on the root surfaces. Histologically, clastic cells were present on the bone surfaces but absent around the root surfaces. Expression of F4/80 and RANKL was not found at close proximity to the root surfaces, but OPG was globally expressed. CONCLUSION: The absence of clastic cells around the root surface of pulp-exposed teeth, in part, is associated with the lack of macrophages and RANKL expression.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Process
[do] DOI:10.1111/odi.12824

  5 / 4164 MEDLINE  
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[PMID]: 29359689
[Au] Autor:Burczynska A; Dziewit L; Decewicz P; Struzycka I; Wroblewska M
[Ad] Address:Department of Dental Microbiology, Medical University of Warsaw, Poland.
[Ti] Title:Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity.
[So] Source:Pol J Microbiol;66(1):9-15, 2017 Mar 30.
[Is] ISSN:1733-1331
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:The composition of the oral microbiome in healthy individuals is complex and dynamic, and depends on many factors, such as anatomical location in the oral cavity, diet, oral hygiene habits or host immune responses. It is estimated at present that worldwide about 2 billion people suffer from diseases of the oral cavity, mainly periodontal disease and dental caries. Importantly, the oral microflora involved in local infections may spread and cause systemic, even life-threatening infections. In search for etiological agents of infections in dentistry, traditional approaches are not sufficient, as about 50% of oral bacteria are not cultivable. Instead, metagenomic analyses are particularly useful for studies of the complex oral microbiome - both in healthy individuals, and in patients with oral and dental diseases. In this paper we review the current and future applications of metagenomic studies in evaluation of both the composition of the oral microbiome as well as its potential pathogenic role in infections in dentistry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Process
[do] DOI:10.5604/17331331.1234988

  6 / 4164 MEDLINE  
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[PMID]: 29284472
[Au] Autor:Daviet-Noual V; Ejeil AL; Gossiome C; Moreau N; Salmon B
[Ad] Address:Dental Medicine Department, Bretonneau Hospital, HUPNVS, AP-HP, Paris, France.
[Ti] Title:Differentiating early stage florid osseous dysplasia from periapical endodontic lesions: a radiological-based diagnostic algorithm.
[So] Source:BMC Oral Health;17(1):161, 2017 12 28.
[Is] ISSN:1472-6831
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Osseous dysplasia (OD) is the most common fibro-osseous lesion of the jaw affecting the periapical region. Early stages of OD can resemble periapical radiolucencies, thus mimicking the radiological aspects of an endodontic pathology. Such radiolucent lesions affecting previously decayed or treated teeth are even more complex to interpret. CASE PRESENTATION: The aim of this paper is to report a case-series of representative clinical situations describing the radiological features and illustrating the diagnostic workup of patients with florid osseous dysplasia (FOD). Emphasis is given to the endodontic implications of such periapical bone disease and the complexity of accurate diagnosis in the context of endodontic retreatment. We then propose a practical radiological-based diagnostic algorithm to assist the clinician in the diagnostic of OD periapical lesions. CONCLUSION: Periapical lesions may be confused with bone diseases such as osseous dysplasia, especially in the radiolucent initial stage. Knowledge of clinical features associated with a careful reading of cone beam CT images, such as fine opacities within the hypodense periapical lesion, may help determine the right diagnostic.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Process
[do] DOI:10.1186/s12903-017-0455-5

  7 / 4164 MEDLINE  
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[PMID]: 29422108
[Au] Autor:Roy DK; Cohen S; Singh VP; Marla V; Ghimire S
[Ad] Address:Department of Conservative Dentistry and Endodontics, Kathmandu Medical College, Kathmandu, Nepal. drdeepak48@gmail.com.
[Ti] Title:Endodontic management of mandibular canine with two roots and two canals: a rare case report.
[So] Source:BMC Res Notes;11(1):111, 2018 Feb 08.
[Is] ISSN:1756-0500
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: In general, mandibular canines have a single root and a single canal. The occurrence of two roots and two canals is a rare entity ranging from 1 to 5%. The anatomy of root canal morphology plays a decisive role in determining the conditions under which endodontic treatment can be performed effectively. Successful endodontic treatment comprises proper diagnosis, meticulous cleaning and shaping followed by three dimensional obturation. Failure to do so may lead to postoperative diseases, pain and further complications. This paper reports successful management of a mandibular canine with two roots and two canals. CASE PRESENTATION: 45-year-old Nepalese women with a non-significant medical history presented with a chief complaint of pain in a lower left front tooth. The pain disturbed her sleep and lingered for several minutes even after removal of a thermal stimulus. Clinical examination and testing revealed generalized severe attrition with tenderness to percussion in the mandibular left canine. Electric pulp test for all the mandibular anteriors revealed almost no response in the mandibular left canine. Intraoral periapical radiographs in different angulations were taken which revealed two roots and two canals. A clinical diagnosis of chronic irreversible pulpitis with symptomatic apical periodontitis was made and root canal therapy was performed following the standard protocols. CONCLUSION: Although the prevalence of two roots and two canals in mandibular canine is very low, the clinician should always be mindful of variations in the number of roots and canals for proper management of such cases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Process
[do] DOI:10.1186/s13104-018-3226-8

  8 / 4164 MEDLINE  
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[PMID]: 29341577
[Au] Autor:Biocanin V; Milic M; Vucetic M; Vasovic M; Zivadinovic D; Zivadinovic M; Cetkovic D; Calasan D; Brkovic B
[Ti] Title:Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report.
[So] Source:Vojnosanit Pregl;73(12):1173-7, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:Introduction: The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report: We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Post-operatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion: Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation.
[Mh] MeSH terms primary: Calcium Compounds/therapeutic use
Diabetes Mellitus, Type 2/complications
Diabetic Neuropathies/etiology
Periapical Diseases/surgery
Root Canal Filling Materials/therapeutic use
Root Canal Obturation
Silicates/therapeutic use
[Mh] MeSH terms secundary: Diabetes Mellitus, Type 2/diagnosis
Diabetes Mellitus, Type 2/physiopathology
Diabetic Neuropathies/diagnosis
Diabetic Neuropathies/physiopathology
Humans
Male
Middle Aged
Pain Perception
Pain Threshold
Pain, Postoperative/complications
Pain, Postoperative/physiopathology
Periapical Diseases/complications
Periapical Diseases/diagnostic imaging
Radiography, Dental
Root Canal Obturation/adverse effects
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Calcium Compounds); 0 (Root Canal Filling Materials); 0 (Silicates); 404G39282C (tricalcium silicate)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150606137B

  9 / 4164 MEDLINE  
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SciELO Brazil full text

[PMID]: 29236918
[Au] Autor:Silveira-Neto N; Flores ME; De Carli JP; Costa MD; Matos FS; Paranhos LR; Linden MSS
[Ad] Address:Departamento de Odontologia, Universidade de Passo Fundo, Passo Fundo, RS, BR.
[Ti] Title:Peri-implant assessment via cone beam computed tomography and digital periapical radiography: an ex vivo study.
[So] Source:Clinics (Sao Paulo);72(11):708-713, 2017 Nov.
[Is] ISSN:1980-5322
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This research evaluated detail registration in peri-implant bone using two different cone beam computer tomography systems and a digital periapical radiograph. METHODS: Three different image acquisition protocols were established for each cone beam computer tomography apparatus, and three clinical situations were simulated in an ex vivo fresh pig mandible: buccal bone defect, peri-implant bone defect, and bone contact. Data were subjected to two analyses: quantitative and qualitative. The quantitative analyses involved a comparison of real specimen measures using a digital caliper in three regions of the preserved buccal bone - A, B and E (control group) - to cone beam computer tomography images obtained with different protocols (kp1, kp2, kp3, ip1, ip2, and ip3). In the qualitative analyses, the ability to register peri-implant details via tomography and digital periapical radiography was verified, as indicated by twelve evaluators. Data were analyzed with ANOVA and Tukey's test (α=0.05). RESULTS: The quantitative assessment showed means statistically equal to those of the control group under the following conditions: buccal bone defect B and E with kp1 and ip1, peri-implant bone defect E with kp2 and kp3, and bone contact A with kp1, kp2, kp3, and ip2. Qualitatively, only bone contacts were significantly different among the assessments, and the p3 results differed from the p1 and p2 results. The other results were statistically equivalent. CONCLUSIONS: The registration of peri-implant details was influenced by the image acquisition protocol, although metal artifacts were produced in all situations. The evaluators preferred the Kodak 9000 3D cone beam computer tomography in most cases. The evaluators identified buccal bone defects better with cone beam computer tomography and identified peri-implant bone defects better with digital periapical radiography.
[Mh] MeSH terms primary: Alveolar Bone Loss/diagnostic imaging
Dental Implants
Mandible/diagnostic imaging
Periapical Diseases/diagnostic imaging
[Mh] MeSH terms secundary: Animals
Cone-Beam Computed Tomography
Radiography, Dental, Digital
Reproducibility of Results
Swine
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Dental Implants)
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Js] Journal subset:IM
[Da] Date of entry for processing:171214
[St] Status:MEDLINE

  10 / 4164 MEDLINE  
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[PMID]: 29172335
[Au] Autor:Razzak A; O'Leary F; Ahmed N
[Ti] Title:Facial Palsy Masquerading as an Acute Dental Abscess.
[So] Source:Dent Update;44(3):241-2, 244-5, 2017 Mar.
[Is] ISSN:0305-5000
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Facial nerve palsy has specific symptomology, but varied aetiology. Prompt and thorough assessment is required to ascertain if upper or lower motor neurone damage has occurred. This report discusses a 6-year-old female, presenting in the Emergency Department with unilateral facial weakness. Initially thought to be facial swelling relating to her carious dentition, clinical assessment from the maxillofacial team identified that the patient had a unilateral facial palsy, later diagnosed as Bell's palsy. Her delayed presentation was due to initial misdiagnoses in primary care. This case report aims to highlight its aetiology, clinical features and appropriate management. Clinical relevance: To make the general dental practitioner aware of different causes of facial paralysis, and to provide GDPs with an algorithm to follow in the presentation of a facial palsy in the primary care setting.
[Mh] MeSH terms primary: Bell Palsy/diagnosis
Periapical Abscess/diagnosis
[Mh] MeSH terms secundary: Acute Disease
Algorithms
Bell Palsy/therapy
Child
Diagnosis, Differential
Female
Humans
Periapical Abscess/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[Js] Journal subset:D
[Da] Date of entry for processing:171128
[St] Status:MEDLINE


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