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Search on : Phlebitis [Words]
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[PMID]: 29524443
[Au] Autor:Palmiero UC; Morosi L; Bello E; Ponzo M; Frapolli R; Matteo C; Ferrari M; Zucchetti M; Minoli L; De Maglie M; Romanelli P; Morbidelli M; D'Incalci M; Moscatelli D
[Ad] Address:Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.
[Ti] Title:Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin.
[So] Source:J Control Release;, 2018 Mar 07.
[Is] ISSN:1873-4995
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The improvement of the pharmacological profile of lipophilic drug formulations is one of the main successes achieved using nanoparticles (NPs) in medicine. However, the complex synthesis procedure and numerous post-processing steps hamper the cost-effective use of these formulations. In this work, an approach which requires only a syringe to produce self-assembling biodegradable and biocompatible poly(caprolactone)-based NPs is developed. The effective synthesis of monodisperse NPs has been made possible by the optimization of the block copolymer synthesized via a combination of ring opening polymerization and reversible addition-fragmentation chain transfer polymerization. These NPs can be used to formulate lipophilic drugs that are barely soluble in water, such as trabectedin, a potent anticancer therapeutic. Its biodistribution and antitumor activity have been compared with the commercially available formulation Yondelis®. The results indicate that this trabectedin NP formulation performs with the same antitumor activity as Yondelis®, but does not have the drawback of severe local vascular toxicity in the injection site.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 5039 MEDLINE  
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[PMID]: 29290000
[Au] Autor:Qiao LD; Chen S; Lin YH; Li JX; Hu WG; Hou JP; Cui L
[Ad] Address:Department of Urology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Dongcheng District, 100730, Beijing, China.
[Ti] Title:Evaluation of perioperative prophylaxis with fosfomycin tromethamine in ureteroscopic stone removal: an investigator-driven prospective, multicenter, randomized, controlled study.
[So] Source:Int Urol Nephrol;50(3):427-432, 2018 Mar.
[Is] ISSN:1573-2584
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To compare efficacy, safety, and cost-effectiveness of fosfomycin tromethamine with other standard-of-care antibiotics in patients undergoing ureteroscopic lithotripsy. METHODS: This study was a prospective, multicenter, randomized, controlled trial. Eligible patients scheduled for ureteroscopic lithotripsy were randomly assigned to receive either fosfomycin (fosfomycin group, N = 101 patients) or standard-of-care antibiotic therapy as prophylaxis (control group, N = 115 patients). The incidence of infectious complications and adverse events was analyzed between the two groups, as well as the cost-benefit analysis. RESULTS: The incidence of infections following lithotripsy was 3.0% in the fosfomycin group and 6.1% in the control group (p > 0.05). Only asymptomatic bacteriuria was reported in fosfomycin group. In the control group was reported asymptomatic bacteriuria (3.5%), fever (0.9%), bacteremia (0.9%), and genitourinary infection (0.9%). The rate of adverse events was very low, with no adverse event reported in the fosfomycin group and only one in the control group (forearm phlebitis). The average cost per patient of antibiotic therapy with fosfomycin was 151.45 ± 8.62 yuan (22.7 ± 1.3 USD), significantly lower compared to the average cost per patient of antibiotics used in the control group 305.10 ± 245.95 yuan (45.7 ± 36.9 USD; p < 0.001). CONCLUSIONS: Two oral doses of 3 g fosfomycin tromethamine showed good efficacy and safety and low cost in perioperative prophylaxis of infections following ureteroscopic stone removal.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process
[do] DOI:10.1007/s11255-017-1776-7

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[PMID]: 29519742
[Au] Autor:Kawada K; Ohta T; Tanaka K; Miyamoto N
[Ad] Address:Pharmaceutical Department, Kochi Health Sciences Center, Kochi, Japan.
[Ti] Title:Reduction of Nicardipine-Related Phlebitis in Patients with Acute Stroke by Diluting Its Concentration.
[So] Source:J Stroke Cerebrovasc Dis;, 2018 Mar 05.
[Is] ISSN:1532-8511
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Nicardipine is frequently used in the treatment of hypertension for patients with acute stroke; however, its dosing is complicated by a high risk of phlebitis. In the present study, we examined whether restricting nicardipine concentration under a specific value could reduce the incidence of nicardipine-related phlebitis in patients with acute stroke. METHODS: Intravenous nicardipine-related phlebitis was retrospectively analyzed. From July 2015, a simple proposition was made to dilute maximum intravenous nicardipine concentration to lower than 130 µg/mL. The maximum intravenous nicardipine concentration and the incidence of phlebitis were compared between patients treated from July 2014 to June 2015 (preproposition group) and patients treated from July 2015 to June 2016 (postproposition group). RESULTS: A total of 300 patients (preproposition group, 138; postproposition group, 162) were included. The postproposition group demonstrated significantly lower maximum intravenous nicardipine concentration (in µg/mL, 76.9, 47.6-104.5 versus 130.4, 69.8-230.8; P < .001) and incidence of phlebitis (9.9%, 16/162 vs. 30%, 42/138; P < .001) than the preproposition group. Multivariable logistic regression analysis revealed that the maximum intravenous nicardipine concentration lower than 130 µg/mL (odds ratio [OR] .15; 95% confidence interval [CI] .06-.35; P < .001) and National Institutes of Health Stroke Scale on admission (OR .95; 95% CI .91-.99; P = .007) were the statistically significant independent factors for phlebitis, which indicated the usefulness of the proposition to dilute maximum intravenous nicardipine concentration to lower than 130 µg/mL. CONCLUSIONS: The simple and appropriate proposition about nicardipine administration lowered maximum nicardipine concentration and reduced the incidence of nicardipine-related phlebitis in patients with acute stroke.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  4 / 5039 MEDLINE  
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[PMID]: 29503084
[Au] Autor:Tang TY; Tiwari A
[Ad] Address:Department of Vascular Surgery, Singapore General Hospital, Singapore. Electronic address: tang.tjun.yip@singhealth.com.sg.
[Ti] Title:The VenaSeal™ Abnormal Red Skin Reaction: Looks Like but is not Phlebitis!
[So] Source:Eur J Vasc Endovasc Surg;, 2018 Mar 01.
[Is] ISSN:1532-2165
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher

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[PMID]: 29489709
[Au] Autor:Gunasegaran N; See MTA; Leong ST; Yuan LX; Ang SY
[Ad] Address:Singapore General Hospital, Singapore (Ms Gunasegaran, Miss See, Ms Leong, Ms Yuan, and Ms Ang). Nanthakumahrie Gunasegaran, MSc, BHS, is currently a nurse clinician. In addition to her master of science degree in clinical leadership, she holds an advanced diploma in medical/surgical nursing, as well as postgraduate certificates in domiciliary nursing and clinical nursing. Min Ting Alicia See, BSc (Hons), is currently a senior staff nurse. Siew Teing Leong, MHSM, BHS, is currently a senior nurse manager. She also holds an advanced diploma in critical care. Long Xia Yuan, BN, is currently a senior nurse manager. She also holds an advanced diploma in gerontology nursing. Shin Yuh Ang, MBA, BSc (Hons), is currently the assistant director of nursing. She also holds an advanced diploma in medical/surgical nursing.
[Ti] Title:A Randomized Controlled Study to Evaluate the Effectiveness of 2 Treatment Methods in Reducing Incidence of Short Peripheral Catheter-Related Phlebitis.
[So] Source:J Infus Nurs;41(2):131-137, 2018 Mar/Apr.
[Is] ISSN:1539-0667
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Short peripheral catheter (SPC)-related phlebitis can lead to bloodstream infections and affect patients' quality of life. A randomized trial was carried out to evaluate the effectiveness of 2 treatment methods in reducing the incidence of SPC-related phlebitis. The 2 treatment methods differed in terms of the cleansing solution used before insertion and dressing material used after removal. The results demonstrated that the type of cleansing solution and postremoval dressing material did not make a difference in the incidence of phlebitis. Strict adherence to aseptic techniques and prompt removal of the SPC remained the cornerstone in the prevention of phlebitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.1097/NAN.0000000000000271

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[PMID]: 29489704
[Au] Autor:Nyika ML; Mukona D; Zvinavashe M
[Ad] Address:University of Zimbabwe College of Health Sciences, Department of Nursing Science, Harare, Zimbabwe (Mr Livion, Mrs Mukona, and Dr Zvinavashe). Munashe Livion Nyika, BSc (Hons), is a former student at the University of Zimbabwe College of Health Sciences who recently graduated with a BSc (Hons) in Nursing Science. Doreen Mukona, MSc, BSc, is a lecturer at the University of Zimbabwe College of Health Sciences who is currently pursuing a DPhil in Nursing Science. She holds a BSc and an MSc in Nursing Science from the same university. Mathilda Zvinavashe, PhD, MSc, is a professor in the Department of Nursing Science in the University of Zimbabwe College of Health Sciences. She earned her MSc in Community Nursing as well as her PhD in Nursing from the University of Michigan in Ann Arbor, Michigan.
[Ti] Title:Factors Contributing to Phlebitis Among Adult Patients Admitted in the Medical-Surgical Units of a Central Hospital in Harare, Zimbabwe.
[So] Source:J Infus Nurs;41(2):96-102, 2018 Mar/Apr.
[Is] ISSN:1539-0667
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This descriptive survey identified factors contributing to phlebitis among 46 adult inpatients using a systematic random sample. The visual infusion phlebitis score was used for assessment. All participants had phlebitis, with stage 4 being most frequent. Factors identified were gender (males-91.7%); immunosuppression (human immunodeficiency virus-63.0%; diabetes-100%; immunosuppressive drugs-100%; absolute leucocyte count <1000 µL-100%); number of catheters inserted (>1-90.9%); site of catheterization (dorsum of wrist-100%); catheter dwell time (2-4 days-100%); catheter gauge (18-gauge-75%); catheter securement (unsecured/contaminated dressing-90%); regularity of catheter flushing (catheter never flushed-72.7%); and continuous infusion (94.2%).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.1097/NAN.0000000000000265

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[PMID]: 29428536
[Au] Autor:Li X; Yang B; Li X; Ren S
[Ad] Address:Department of Neurology, First Affiliated Hospital of Jiamusi University, Helongjiang, China.
[Ti] Title:Prospective Comparison of Effect of Ligation and Foam Sclerotherapy with Foam Sclerotherapy Alone for Varicose Veins.
[So] Source:Ann Vasc Surg;, 2018 Feb 09.
[Is] ISSN:1615-5947
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: To compare the efficacy of ligation after foam sclerotherapy (FSL) with foam sclerotherapy (FS) alone for patients with varicose veins prospectively. METHODS: Ninety-four patients with varicose veins underwent foam sclerothrapy alone and 88 patients with varicose veins received FSL. Patients were followed up at 1, 3, 6, and 12 months after treatment. The postoperative complications were documented prospectively. RESULTS: In comparison with patients who underwent FSL, patients treated with FS only had higher incidence of phlebitis within 4 weeks (14.9% vs. 1.1%, P = 0.002) and at 6 months (10.6% vs. 0, P = 0.002) after treatment and had higher incidence of tenderness or discomfort (9.8% vs. 0, P = 0.003) and recanalization rate (8.5% vs. 1.1%, P = 0.007) at 6 months after treatment. All patients in both groups had no deep vein thrombosis and pulmonary embolism. CONCLUSIONS: Patients treated with FSL have less postoperative complications than those with foam sclerotheray alone. FSL is an alternative procedure for management of patients with varicose veins. Also, a randomized prospective study is required to observe the long-term outcomes of the FSL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180224
[Lr] Last revision date:180224
[St] Status:Publisher

  8 / 5039 MEDLINE  
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[PMID]: 29472509
[Au] Autor:Meng L; Nguyen CM; Patel S; Mlynash M; Caulfield AF
[Ad] Address:Stanford Health Care, Stanford, CA. lmeng@stanfordhealthcare.org.
[Ti] Title:Association between continuous peripheral i.v. infusion of 3% sodium chloride injection and phlebitis in adults.
[So] Source:Am J Health Syst Pharm;75(5):284-291, 2018 Mar 01.
[Is] ISSN:1535-2900
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: One institution's experience with use of peripheral i.v. (PIV) catheters for prolonged infusions of 3% sodium chloride injection at rates up to 100 mL/hr is described. METHODS: A prospective, observational, 13-month quality assurance project was conducted at an academic medical center to evaluate frequencies of patient and catheter phlebitis among adult inpatients who received both an infusion of 3% sodium chloride injection for a period of ≥4 hours through a dedicated PIV catheter and infusions of routine-care solutions (RCSs) through separate PIV catheters during the same hospital stay. RESULTS: Sixty patients received PIV infusions through a total of 291 catheters during the study period. The majority of patients (78%) received infusions of 3% sodium chloride injection for intracranial hypertension, with 30% receiving such infusions in the intensive care unit. Phlebitis occurred in 28 patients (47%) during infusions of 3% sodium chloride and 26 patients (43%) during RCS infusions ( = 0.19). Catheter phlebitis occurred in 73 catheters (25%), with no significant difference in the frequencies of catheter phlebitis with infusion of 3% sodium chloride versus RCSs (30% [32 of 106 catheters]) versus 22% [41 of 185 catheters]), = 0.16). CONCLUSION: Patient and catheter phlebitis rates were not significantly different with infusions of 3% sodium chloride injection versus RCSs, suggesting that an osmolarity cutoff value of 900 mOsm/L for peripheral infusions of hypertonic saline solutions may not be warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:In-Data-Review
[do] DOI:10.2146/ajhp161028

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[PMID]: 29450334
[Au] Autor:Calugaru D; Calugaru M
[Ad] Address:Department of Ophthalmology, University of Medicine Cluj-Napoca, Romania.
[Ti] Title:Central retinal vein occlusion in a young adult Case report.
[So] Source:Rom J Ophthalmol;60(2):120-124, 2016 Apr-Jun.
[Is] ISSN:2457-4325
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the case of a 48-year-old man with unilateral central retinal vein occlusion. METHODS: The clinical, hematologic and hypercoagulability evaluations of the patient were thoroughly and specifically carried out. RESULTS: The central retinal vein occlusion was of nonischemic type and was associated with polyglobulia, hyperleukocytosis, hypercholesterolemia, multiple dental foci, and pulmonary sequelae of tuberculosis. CONCLUSIONS: When a patient less than 50 years of age experiences central retinal vein occlusion, other mechanisms, such as the hyperviscosity syndrome or the inflammatory condition (inflammation of the central retinal vein) should be specifically considered and accounted for.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  10 / 5039 MEDLINE  
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[PMID]: 29381959
[Au] Autor:Wu PC; Tien PT; Li YH; Chen RY; Cho DY
[Ad] Address:Division of Rheumatology and Immunology, Department of Internal Medicine, China Medical University Hospital.
[Ti] Title:IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.
[So] Source:Medicine (Baltimore);96(47):e8709, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system. PATIENT CONCERNS: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. She also reported a painless right submandibular mass that had been present for 1 year. Her best-corrected visual acuity (BCVA) was 2.0 LogMAR, with an almost total visual field defect in the right eye. DIAGNOSES: Magnetic resonance imaging (MRI) revealed lobulated parasellar tumors with perineural spreading along branches of the trigeminal nerves causing right optic nerve compression. A craniotomy with tumor removal and submandibular gland biopsy was performed. Histopathological analysis of the tumor revealed stromal fibrosis with atypical lymphoid infiltrations. Histopathological and immunohistochemical analysis of the submandibular gland confirmed the diagnosis of IgG4-RD. INTERVENTIONS: The patient was administered 500mg/d of pulse methylprednisolone for 3 days, 500mg of intravenous rituximab every 2 weeks (for a total of 2 doses), and 500mg of intravenous pulse cyclophosphamide every month (for a total of 3 doses). OUTCOMES: Two months after the initiation of immunosuppressive therapy, the patient's BCVA returned to 0.1 LogMAR with visual field defect recovery. The follow-up MRI showed the almost complete disappearance of the previously contrast-enhanced lesions. LESSONS: Herein, we report a rare case of IgG4-RD presenting as a parasellar tumor and present a review of the related literature. Based on the case report, we propose that aggressive therapy with glucocorticoid, rituximab, and cyclophosphamide may potentially be useful for treating such cases.
[Mh] MeSH terms primary: Immunoglobulin G/immunology
Optic Nerve Diseases/immunology
Pseudotumor Cerebri/immunology
Trigeminal Nerve/pathology
[Mh] MeSH terms secundary: Adolescent
Female
Humans
Magnetic Resonance Imaging
Methylprednisolone/therapeutic use
Optic Nerve Diseases/drug therapy
Optic Nerve Diseases/surgery
Pseudotumor Cerebri/drug therapy
Pseudotumor Cerebri/surgery
Rituximab/therapeutic use
Submandibular Gland/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008709


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