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[PMID]: 29468889
[Au] Autor:Mamadalieva NZ; Youssef FS; Ashour ML; Sasmakov SA; Tiezzi A; Azimova SS
[Ad] Address:a Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan , Tashkent , Uzbekistan.
[Ti] Title:Chemical composition, antimicrobial and antioxidant activities of the essential oils of three Uzbek Lamiaceae species.
[So] Source:Nat Prod Res;:1-4, 2018 Feb 22.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The chemical composition of the essential oil from the aerial parts of three Lamiaceae species from Uzbekistan was investigated by GC-MS analysis. ß-Linalool (26.6%), α-terpineol (10.0%), coumarin (8.9%) and 4,5,7,7α-tetrahydro-4,4,7α-trimethyl-2(6H)-benzofuranone (5.4%) resulted as the main components of Ajuga turkestanica essential oil, while camphene (17.1%), 1,8-cineole (15.9%), ß-cymene (7.9%) and limonene (7.4%) in Phlomis regelii. The essential oil of Thymus seravschanicus was dominated by thymol (37.5%), phellandral (26.0%), τ-terpinene (6.6%) and ß-cymene (5.2%). The essential oils had considerable antimicrobial activity against different bacterial strains and fungi. Among the tested samples of essential oils, P. regelii essential oil has the significant antioxidant activity with IC value of 117.8 ± 8.02 µg/mL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1443088

  2 / 119 MEDLINE  
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[PMID]: 29177694
[Au] Autor:Palutoglu M; Akgul B; Suyarko V; Yakovenko M; Kryuchenko N; Sasmaz A
[Ad] Address:Geology Department, Firat University, 23119, Elazig, Turkey.
[Ti] Title:Phytoremediation of Cadmium by Native Plants Grown on Mining Soil.
[So] Source:Bull Environ Contam Toxicol;100(2):293-297, 2018 Feb.
[Is] ISSN:1432-0800
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The Gümüsköy mining area is located about 25 km west of Kutahya and is the largest silver deposit in Turkey. The present study investigated translocation and accumulation of cadmium (Cd) from the soil into 11 native plants. Plant and soil samples were collected from the field, and Cd concentrations were analyzed by inductively coupled plasma mass spectroscopy. Mean Cd values in the soil, root, and shoot of native plants in the study area were 82.8 ± 5, 55.4 ± 6, and 43.5 ± 4 mg kg , respectively. Plants were separated into several groups according to the enrichment coefficients for shoot and root values of plants. These groups showed Carduus nutans and Phlomis could be potentially bioaccumulator plants useful for phytoremediation of mining soils contaminated by Cd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Process
[do] DOI:10.1007/s00128-017-2220-5

  3 / 119 MEDLINE  
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[PMID]: 29035246
[Au] Autor:Dogan Sigva ZÖ; Hasvatan EE; Gülen G; Uslu R; Eryildiz B; Durmuskahya C; Kayalar H; Özbilgin A; Korkmaz M; Gündüz C
[Ad] Address:Ege Üniversitesi Tip Fakültesi, Tibbi Biyoloji Anabilim Dali, Izmir, Türkiye. ozlemdogan99@gmail.com.
[Ti] Title:Effect of Extracts of the Endemic Plants Centaurea lydia and Phlomis nissolii on Toxoplasma gondii.
[So] Source:Turkiye Parazitol Derg;41(3):164-168, 2017 Sep.
[Is] ISSN:2146-3077
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This study aimed to investigate the potential antitoxoplasma activities of extracts of the endemic plants Centaurea lydia and Phlomis nissolii in a fibroblast cell culture infected with T. gondii trophozoites. METHODS: WI-38 cell lines treated with plant extracts (55 µg/mL each) and an untreated control were infected with 5×105 T. gondii trophozoites, and the number of parasites in the medium was determined on days 7, 14, and 24. RESULTS: No cytotoxic effects of C. lydia and P. nissolii extracts were detected at concentrations of 0.86-55 µg/mL in the WI-38 cell line, and the absence of the cytotoxicity of these extracts on the fibroblast cell line was considered as a positive effect. C. lydia extract at 55 µg/mL had marked activity against T. gondii trophozoites. A 47.5-fold increase was observed in the number of trophozoites in the control group, while a 84-fold decrease was found in the C. lydia extract group. However, a 36-fold increase was detected in the P. nissolii extract group, indicating no antitoxoplasma activity. CONCLUSION: The extract of C. lydia, an endemic plant, was found to be a good drug candidate for treating toxoplasmosis. The in vitro activity of the extract of this endemic plant should be further investigated in animal models in vivo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[St] Status:In-Process
[do] DOI:10.5152/tpd.2017.5451

  4 / 119 MEDLINE  
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[PMID]: 28990061
[Au] Autor:Zhang X; Li W; Abudureheman A; Cheng T; Peng P
[Ad] Address:Department of Emergency Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
[Ti] Title:Imperatorin possesses notable anti­inflammatory activity in vitro and in vivo through inhibition of the NF­κB pathway.
[So] Source:Mol Med Rep;16(6):8619-8626, 2017 Dec.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Imperatorin (IMT) is a furanocoumarin from the root of Phlomis younghusbandii (Lamiaceae) with various activities. In the present study, the anti­inflammatory effects of IMT were evaluated by examining dimethylbenzene­induced ear edema, acetic acid­induced vascular permeability and by performing cotton pellet granuloma assessments in mice. In addition, the expression of pro­inflammatory cytokines, including tumor necrosis factor (TNF)­α, interleukin (IL)­6 and IL­1ß, were detected using enzyme­linked immunosorbent assay kits in mice and using reverse transcription polymerase chain reaction analysis in RAW 264.7 cells. The expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase­2 (COX­2), nuclear p65, cytosolic p65 and inhibitor of nuclear factor (NF)­κB (IκB) in RAW 264.7 cells were determined using western blot analysis. The results showed that the oral administration of IMT significantly inhibited the inflammatory reactions and reduced the release of TNF­α, IL­6 and IL­1ß reactions and reduced and suppressed the mRNA expression of TNF­A expressionact1o, and the protein expression of iNOS and COX­2 in the RAW 264.7 cells. The results also indicated that IMT suppressed the activity of NF­κB via upregulating p65 and IκB in the cytoplasm and downregulating p65 in the nucleus. In conclusion, IMT possessed notable anti­inflammatory activities in vitro and in vivo through inhibiting the NF­κB pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.7706

  5 / 119 MEDLINE  
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[PMID]: 28983983
[Au] Autor:Aghakhani F; Kharazian N; Lori Gooini Z
[Ad] Address:Department of Botany, Faculty of Sciences, Shahrekord University, Shahrekord, Iran.
[Ti] Title:Flavonoid Constituents of Phlomis (Lamiaceae) Species Using Liquid Chromatography Mass Spectrometry.
[So] Source:Phytochem Anal;, 2017 Oct 05.
[Is] ISSN:1099-1565
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Phlomis is one of the medicinal genera of Lamiaceae. This genus has unique medicinal properties. Consequently, appropriate methods need to be described for the identification of the chemical compounds. OBJECTIVE: A liquid chromatography tandem mass spectrometry (LC-MS/MS) technique on a triple quadrupole mass spectrometer (TQMS) was used for separation and identification of leaf flavonoid compounds for seven Phlomis species including Phlomis kurdia, Ph. aucheri, Ph. olivieri, Ph. bruguieri, Ph. persica, Ph. anisodonta and Ph. elliptica. METHODOLOGY: The flavonoid solution of air-dried leaves (10.5 g) was extracted using 85% methanol. The chromatogram was treated with three systems: methanol-water, chloroform-methanol and acetic acid. The extracts were analysed using LC-MS/MS. The MS detection was performed under negative mode electrospray ionisation (ESI). The identification of constituents was based on authentic references used in the identification process. RESULTS: A total of 35 chemical compounds were detected from which 32 were identified as flavonoids through comparison with published literature and reference standards. These compounds were distributed in four flavonoid classes. Flavones (12), flavonols (11), flavanones (8) and flavane (1) were the main groups appearing in almost all of the studied samples. The flavonoids such as naringenin, chrysoeriol, eriodictyol, dimethoxyflavanone, apigenin, luteolin, kaempferol and rhamnetin were in high proportions. Moreover, 22 flavonoid compounds were first reported in this study for Phlomis species. CONCLUSION: The fragmentation patterns of the compounds during collision induced dissociation (CID) clarified information of the compounds analysed. The detailed flavonoid compositions of Phlomis species provide the appropriate context from phytochemical and phytotherapeutics points of view. Copyright © 2017 John Wiley & Sons, Ltd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[St] Status:Publisher
[do] DOI:10.1002/pca.2733

  6 / 119 MEDLINE  
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[PMID]: 28877668
[Au] Autor:Baldé A; Neves D; García-Breijo FJ; Pais MS; Cravador A
[Ad] Address:Plant Molecular Biology and Biotechnology Lab, Center for Biosystems (BioSys), Functional and Integrative Genomics (BioFIG), Edifício C2, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisbon, Portugal.
[Ti] Title:De novo assembly of Phlomis purpurea after challenging with Phytophthora cinnamomi.
[So] Source:BMC Genomics;18(1):700, 2017 Sep 06.
[Is] ISSN:1471-2164
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Phlomis plants are a source of biological active substances with potential applications in the control of phytopathogens. Phlomis purpurea (Lamiaceae) is autochthonous of southern Iberian Peninsula and Morocco and was found to be resistant to Phytophthora cinnamomi. Phlomis purpurea has revealed antagonistic effect in the rhizosphere of Quercus suber and Q. ilex against P. cinnamomi. Phlomis purpurea roots produce bioactive compounds exhibiting antitumor and anti-Phytophthora activities with potential to protect susceptible plants. Although these important capacities of P. purpurea have been demonstrated, there is no transcriptomic or genomic information available in public databases that could bring insights on the genes underlying this anti-oomycete activity. RESULTS: Using Illumina technology we obtained a de novo assembly of P. purpurea transcriptome and differential transcript abundance to identify putative defence related genes in challenged versus non-challenged plants. A total of 1,272,600,000 reads from 18 cDNA libraries were merged and assembled into 215,739 transcript contigs. BLASTX alignment to Nr NCBI database identified 124,386 unique annotated transcripts (57.7%) with significant hits. Functional annotation identified 83,550 out of 124,386 unique transcripts, which were mapped to 141 pathways. 39% of unigenes were assigned GO terms. Their functions cover biological processes, cellular component and molecular functions. Genes associated with response to stimuli, cellular and primary metabolic processes, catalytic and transporter functions were among those identified. Differential transcript abundance analysis using DESeq revealed significant differences among libraries depending on post-challenge times. Comparative cyto-histological studies of P. purpurea roots challenged with P. cinnamomi zoospores and controls revealed specific morphological features (exodermal strips and epi-cuticular layer), that may provide a constitutive efficient barrier against pathogen penetration. Genes involved in cutin biosynthesis and in exodermal Casparian strips formation were up-regulated. CONCLUSIONS: The de novo assembly of transcriptome using short reads for a non-model plant, P. purpurea, revealed many unique transcripts useful for further gene expression, biological function, genomics and functional genomics studies. The data presented suggest a combination of a constitutive resistance and an increased transcriptional response from P. purpurea when challenged with the pathogen. This knowledge opens new perspectives for the understanding of defence responses underlying pathogenic oomycete/plant interaction upon challenge with P. cinnamomi.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170910
[Lr] Last revision date:170910
[St] Status:In-Process
[do] DOI:10.1186/s12864-017-4042-6

  7 / 119 MEDLINE  
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[PMID]: 28732808
[Au] Autor:Song J; Lee D; Min B; Bae JS; Chang GT; Kim H
[Ad] Address:Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea.
[Ti] Title:Safety evaluation of Astragalus extract mixture HT042 and its constituent herbs in Sprague-Dawley rats.
[So] Source:Phytomedicine;32:59-67, 2017 Aug 15.
[Is] ISSN:1618-095X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Astragalus extract mixture HT042 is a combination of three standardized extracts from Astragalus membranaceus root, Eleutherococcus senticosus stem, and Phlomis umbrosa root, which has proven to stimulate children's height growth. PURPOSE: The aim of this study was to demonstrate the safety of HT042 and its three constituent herbs when administered orally. METHODS: Acute and sub-chronic oral toxicity studies were conducted using male and female Sprague-Dawley rats. In the acute toxicity study, HT042 and each of the herbs was administered at single doses of up to 5000 mg/kg. In the 13-week sub-chronic toxicity study, HT042 was administered at repeated doses of up to 4000 mg/kg/day. RESULTS: In the acute toxicity study of HT042 and each of the herbs, no deaths occurred and there was no indication of toxicity, on the basis of clinical signs, body weight, and necropsy findings. In the sub-chronic toxicity study of HT042, there were no deaths and no changes in clinical signs or the findings of ophthalmic examinations. Although there were some treatment-related changes in other findings, these alterations were not considered toxicologically significant because they remained within normal ranges or recovered during the recovery period. CONCLUSION: The oral approximate lethal doses of HT042 and each of the herbs were > 5000 mg/kg, and the no-observed-adverse-effect level of HT042 was 4000 mg/kg/day in male and female rats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170722
[Lr] Last revision date:170722
[St] Status:In-Process

  8 / 119 MEDLINE  
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[PMID]: 28386896
[Au] Autor:Arbia L; Chikhi-Chorfi N; Betatache I; Pham-Huy C; Zenia S; Mameri N; Drouiche N; Lounici H
[Ad] Address:Ecole Nationale Polytechnique d'Alger, Laboratoire BIOGEP, B.P. 182-16200, El Harrach, Alger, Algeria.
[Ti] Title:Antimicrobial activity of aqueous extracts from four plants on bacterial isolates from periodontitis patients.
[So] Source:Environ Sci Pollut Res Int;24(15):13394-13404, 2017 May.
[Is] ISSN:1614-7499
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Four aqueous extracts of different plant organs are the following: Artemisia herba-alba, Opuntia ficus-indica, Camellia sinensis and Phlomis crinita were evaluated against two bacterial strains: Porphyromonas gingivalis and Prevotella intermedia, which are implicated in periodontal diseases. By using a disc method, these plant extracts demonstrated powerful bacterial activity against these Gram-negative strains. The minimum inhibitory concentration values of the four plant extracts varied between 0.03 and 590.82 mg/ml for the microbes. Another assay using commercial antibiotics and antibacterials as positive controls was also conducted. Values obtained after statistical analysis of inhibition diameters of all plant extracts demonstrated that for P. gingivalis, the aqueous extracts of A. herba-alba and O. ficus-indica were most effective, followed by those of C. sinensis and P. crinita. For P. intermedia, aqueous extracts of O. ficus-indica and C. sinensis appeared to be more efficient with significantly different (P > 0.05) inhibition diameters, followed by those of O. ficus-indica and P. crinita. In summary, the statistical results reveal that these plant extracts exert stronger antibacterial activity on P. intermedia germ as compared to P. gingivalis.
[Mh] MeSH terms primary: Anti-Infective Agents/pharmacology
Periodontitis
[Mh] MeSH terms secundary: Anti-Bacterial Agents/pharmacology
Humans
Periodontal Diseases
Plant Extracts/pharmacology
Porphyromonas gingivalis
Prevotella intermedia
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Plant Extracts)
[Em] Entry month:1706
[Cu] Class update date: 171104
[Lr] Last revision date:171104
[Js] Journal subset:IM
[Da] Date of entry for processing:170408
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8942-4

  9 / 119 MEDLINE  
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[PMID]: 28352356
[Au] Autor:Zhang X; Dong Y; Dong H; Zhang W; Li F
[Ad] Address:Rheumatism Immunity Branch, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China.
[Ti] Title:Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis.
[So] Source:Exp Ther Med;13(2):710-716, 2017 Feb.
[Is] ISSN:1792-0981
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Mukerjee (Labiatae) has been reported to be effective in the treatment of rheumatoid arthritis (RA). In the present study, the anti-inflammatory and anti-arthritic effects of phlomisoside F (PF), isolated from Mukerjee (Labiatae), were investigated in male Wistar rats subjected to carrageen-induced paw edema and complete Freund's adjuvant (CFA)-induced arthritis. Arthritis scores were evaluated by a 5-point ordinal scale (scores 0-4). Expression levels of TNF-α, IL-1ß, IL-6, IL-10, COX-2 and 5-LOX were determined via ELISA and western blot assays. Subsequent to establishing the edema and arthritis models, oral administration of PF (5, 10 and 20 mg/kg) significantly inhibited mean edema rate, compared with the control group in carrageenan-induced paw edema assay. In addition, administration of PF (5, 10 and 20 mg/kg/day) for 28 days markedly exhibited an anti-arthritic activity by offsetting the body weight loss, inhibiting the paw edema, reducing the arthritis scores and the indices of thymus and spleen, inhibiting the expression levels of TNF-α, IL-1ß, IL-6, COX-2 and 5-LOX, and increasing the expression of IL-10, when compared with the respective control group in CFA-induced arthritis assay. In conclusion, PF is a valuable anti-arthritic constituent of , and the present study results suggest that this herb may be used in the treatment of RA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3892/etm.2016.3995

  10 / 119 MEDLINE  
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[PMID]: 28155254
[Au] Autor:Bajalan I; Rouzbahani R; Pirbalouti AG; Maggi F
[Ad] Address:Young Researchers and Elite Club of Islamic Azad University, Borujerd Branch, Navab Street, Borujerd, Lorestan Province, Iran.
[Ti] Title:Variation in Chemical Composition and Antibacterial Activity of the Essential Oil of Wild Populations of Phlomis olivieri.
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Various species of the genus Phlomis have been reported to produce metabolites demonstrating significant pharmacological efficiency. In this study, the essential oils from twelve populations of Phlomis olivieri collected from natural habitats were investigated for their chemical components. The hydrodistillated essential oil analyzed by GC-FID and GC/MS. Analyses revealed 27 compounds, constituting 90.52 - 98.51% of the essential oils. Results indicated that the major components of the essential oils from various populations of P. olivieri were germacrene D (26.54 - 56.41%), bicyclogermacrene (6.38 - 30.55%), ß-caryophyllene (5.32 - 24.52%) and α-pinene (1.29 - 15.53%). Principal component analyses (PCA) was used to identify any geographical variations in essential oil composition. Notably, three groups of Iranian P. olivieri populations were determined according to the major compounds. Results of the in vitro antibacterial activity indicated that P. olivieri essential oils showed good inhibitory activities against bacteria, especially Bacillus subtilis. The results of this study gave new insights for cultivation and industrial uses of P. olivieri in Iran.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Oils, Volatile/chemistry
Phlomis/chemistry
[Mh] MeSH terms secundary: Bacillus subtilis/drug effects
Gas Chromatography-Mass Spectrometry
Iran
Monoterpenes/analysis
Oils, Volatile/analysis
Oils, Volatile/pharmacology
Principal Component Analysis
Sesquiterpenes/analysis
Sesquiterpenes, Germacrane/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); BHW853AU9H (caryophyllene); JPF3YI7O34 (alpha-pinene); V2I9ATG34E (germacrene D)
[Em] Entry month:1707
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[Js] Journal subset:IM
[Da] Date of entry for processing:170204
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600444


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