Database : MEDLINE
Search on : Placental and Circulation [Words]
References found : 5416 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 542 go to page                         

  1 / 5416 MEDLINE  
              next record last record
select
to print
Photocopy
Clinical Trials Registry
Full text

[PMID]: 29482567
[Au] Autor:Mannaerts D; Faes E; Gielis J; Van Craenenbroeck E; Cos P; Spaanderman M; Gyselaers W; Cornette J; Jacquemyn Y
[Ad] Address:Departement of Obstetrics and Gynaecology, Antwerp University Hospital, Antwerp, Belgium.
[Ti] Title:Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study.
[So] Source:BMC Pregnancy Childbirth;18(1):60, 2018 02 27.
[Is] ISSN:1471-2393
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Pre-eclampsia (PE) is related to an impaired endothelial function. Endothelial dysfunction accounts for altered vascular reactivity, activation of the coagulation cascade and loss of vascular integrity. Impaired endothelial function originates from production of inflammatory and cytotoxic factors by the ischemic placenta and results in systemic oxidative stress (OS) and an altered bioavailability of nitric oxide (•NO). The free radical •NO, is an endogenous endothelium-derived relaxing factor influencing endothelial function. In placental circulation, endothelial release of •NO dilates the fetal placental vascular bed, ensuring feto-maternal exchange. The Endopreg study was designed to evaluate in vivo endothelial function and to quantify in vitro OS in normal and pre-eclamptic pregnancies. METHODS/DESIGN: The study is divided into two arms, a prospective longitudinal study and a matched case control study. In the longitudinal study, pregnant patients ≥18years old with a singleton pregnancy will be followed throughout pregnancy and until 6months post-partum. In the case control study, cases with PE will be compared to matched normotensive pregnant women. Maternal blood concentration of superoxide (O •) and placental concentration of •NO will be determined using EPR (electron paramagnetic resonance). Endothelial function and arterial stiffness will be evaluated using respectively Peripheral Arterial Tonometry (PAT), Flow-Mediated Dilatation (FMD) and applanation tonometry. Placental expression of eNOS (endothelial NOS) will be determined using immune-histochemical staining. Target recruitment will be 110 patients for the longitudinal study and 90 patients in the case-control study. DISCUSSION: The results of Endopreg will provide longitudinal information on in vivo endothelial function and in vitro OS during normal pregnancy and PE. Adoption of these vascular tests in clinical practice potentially predicts patients at risk to develop cardiovascular events later in life after PE pregnancies. •NO, O • and eNOS measurements provide further inside in the pathophysiology of PE. TRIAL REGISTRATION: This trial has been registered on clinicaltrials.gov. ClinicalTrials.gov Identifier: NCT02603913 . Registered October 2015.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.1186/s12884-018-1685-5

  2 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29520867
[Au] Autor:Mohta M; Duggal S; Chilkoti GT
[Ad] Address:Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
[Ti] Title:Randomised double-blind comparison of bolus phenylephrine or ephedrine for treatment of hypotension in women with pre-eclampsia undergoing caesarean section.
[So] Source:Anaesthesia;, 2018 Mar 09.
[Is] ISSN:1365-2044
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Treatment of post-spinal hypotension during caesarean section assumes special concern in pre-eclamptic patients due to a compromised fetoplacental circulation and increased risk of placental hypoperfusion. Phenylephrine and ephedrine are the most commonly used vasopressors, although the best choice is still not clear. We studied 80 pre-eclamptic women with a singleton pregnancy who underwent caesarean section with spinal anaesthesia, and who developed hypotension defined as a decrease in systolic arterial pressure ≥ 20% from baseline or absolute value < 100 mmHg. Women were randomly allocated to receive phenylephrine 50 g or ephedrine 4 mg boluses for treatment of hypotension. Blood pressure changes following vasopressor administration were similar in both groups, but heart rate remained higher after ephedrine at all time-points. The primary outcome measure of umbilical artery pH was 7.26 (0.11) in the phenylephrine group and 7.25 (0.09) in the ephedrine group (p = 0.86). The incidence of neonatal acidosis (umbilical artery pH < 7.20) was 9 (22.5%) in the phenylephrine group and 11 (27.5%) in the ephedrine group (p = 0.80). Other secondary outcome measures were comparable. In conclusion, phenylephrine 50 g and ephedrine 4 mg, administered as intravenous boluses to treat post-spinal hypotension during caesarean section in pre-eclamptic patients, resulted in similar fetal acid-base values, were equally effective in treating hypotension and were associated with good maternal and neonatal outcome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/anae.14268

  3 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29408374
[Au] Autor:Jensen VFH; Mlck AM; Lykkesfeldt J; Bgh IB
[Ad] Address:Toxicology, Safety Pharm and Pathology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark. Electronic address: vfhj@novonordisk.com.
[Ti] Title:Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat.
[So] Source:Reprod Toxicol;77:1-24, 2018 Feb 03.
[Is] ISSN:1873-1708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  4 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28454691
[Au] Autor:Conka J; Konecn B; Laukov L; Vlkov B; Celec P
[Ad] Address:Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
[Ti] Title:Fetal DNA does not induce preeclampsia-like symptoms when delivered in late pregnancy in the mouse.
[So] Source:Placenta;52:100-105, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The etiology of preeclampsia is unclear. Fetal DNA is present in higher concentrations in the plasma of pregnant women suffering from preeclampsia than in the plasma of healthy pregnant women. A previously published study has shown that human fetal DNA injected into pregnant mice induces preeclampsia-like symptoms when administered between gestation days 10-14. The aim of our experiment was to determine whether or not similar effects would be induced by administration of human and mouse fetal DNA, as well as mouse adult DNA and lipopolysaccharide during late pregnancy in the mouse. METHODS: Experimental animals were injected daily intraperitoneally during gestation days 14-18 with either saline - negative control, lipopolysaccharide - positive control, or various types of DNA. On gestation day 19, blood pressure and proteinuria were measured, and placental and fetal weights were recorded. RESULTS: Fetal and placental hypotrophy were induced only by lipopolysaccharide (p<0.001). Neither fetal nor adult DNA induced changes in fetal/placental weight. None of the experimental groups had higher blood pressure or urinary protein in comparison to saline treated animals. DISCUSSION: In our experiment, we found that there was no effect from intraperitoneally injected human fetal DNA, mouse fetal DNA, or mouse adult DNA on pregnant mice. Additionally, relatively high doses of various types of DNA did not induce preeclampsia-like symptoms in mice when administered in late pregnancy. Our negative results support the hypothesis that the increase of fetal DNA circulating in maternal circulation during the third trimester is rather a consequence than a cause of preeclampsia.
[Mh] MeSH terms primary: Blood Pressure/physiology
Cell-Free Nucleic Acids/administration & dosage
Placenta/physiopathology
Pre-Eclampsia/etiology
[Mh] MeSH terms secundary: Animals
Disease Models, Animal
Female
Lipopolysaccharides
Mice
Pre-Eclampsia/physiopathology
Pregnancy
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cell-Free Nucleic Acids); 0 (Lipopolysaccharides)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170430
[St] Status:MEDLINE

  5 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29289577
[Au] Autor:Ono H; Numakura C; Homma K; Hasegawa T; Tsutsumi S; Kato F; Fujisawa Y; Fukami M; Ogata T
[Ad] Address:Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
[Ti] Title:Longitudinal serum and urine steroid metabolite profiling in a 46,XY infant with prenatally identified POR deficiency.
[So] Source:J Steroid Biochem Mol Biol;178:177-184, 2018 Apr.
[Is] ISSN:1879-1220
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Although POR deficiency (PORD) is assumed to be accompanied by excessive placental androgen accumulation and enhanced adrenal and testicular androgen production via the backdoor pathway as well as compromised testicular androgen production via the frontdoor pathway, there is no direct evidence for the flux of excessive placental androgens into the fetal circulation and for the production of dihydrotestosterone (DHT) via the backdoor pathway. We examined longitudinal serum and urine steroid metabolite profiles in a 46,XY infant with PORD who was prenatally identified because of the progressive fetal masculinization and maternal virilization from the mid-gestation and the presence of fetal radio-humeral synostosis and was confirmed to have compound heterozygous mutations of POR (p.Q201X and p.R457H). The results showed (1) markedly and inappropriately elevated serum androstenedione and testosterone (T) values at birth, (2) a markedly increased serum DHT value with a normal DHT/T ratio at birth, (3) transient elevation of serum T and DHT values accompanied by a normal DHT/T ratio and concomitant elevations of intermediate steroid metabolites on both the frontdoor and backdoor pathways at 30 days of age, and (4) persistent PORD-compatible urine steroid profiles. Although the data obtained from a single infantile patient are too premature to be generalized, they imply: (1) the transfer of excessive placental androgens into the fetal as well as the maternal circulations from the mid-gestation, (2) lack of a clinically discernible amount of DHT production via the adrenal backdoor pathway around birth, and (3) the activation of both the frontdoor and backdoor pathways in the testis around the mini-puberty, with no production of a clinically discernible amount of DHT via the testicular backdoor pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review

  6 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29361796
[Au] Autor:Natarajan SK; Ibdah JA
[Ad] Address:Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583-0806, USA. snatarajan2@unl.edu.
[Ti] Title:Role of 3-Hydroxy Fatty Acid-Induced Hepatic Lipotoxicity in Acute Fatty Liver of Pregnancy.
[So] Source:Int J Mol Sci;19(1), 2018 Jan 22.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Acute fatty liver of pregnancy (AFLP), a catastrophic illness for both the mother and the unborn offspring, develops in the last trimester of pregnancy with significant maternal and perinatal mortality. AFLP is also recognized as an obstetric and medical emergency. Maternal AFLP is highly associated with a fetal homozygous mutation (1528G>C) in the gene that encodes for mitochondrial long-chain hydroxy acyl-CoA dehydrogenase (LCHAD). The mutation in LCHAD results in the accumulation of 3-hydroxy fatty acids, such as 3-hydroxy myristic acid, 3-hydroxy palmitic acid and 3-hydroxy dicarboxylic acid in the placenta, which are then shunted to the maternal circulation leading to the development of acute liver injury observed in patients with AFLP. In this review, we will discuss the mechanistic role of increased 3-hydroxy fatty acid in causing lipotoxicity to the liver and in inducing oxidative stress, mitochondrial dysfunction and hepatocyte lipoapoptosis. Further, we also review the role of 3-hydroxy fatty acids in causing placental damage, pancreatic islet -cell glucolipotoxicity, brain damage, and retinal epithelial cells lipoapoptosis in patients with LCHAD deficiency.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  7 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29486852
[Au] Autor:Kong W; Gong Y; Zhou R; Wang Y; Zhang Y; Luo X; Zhang L; Wang T
[Ad] Address:Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, P.R. China.
[Ti] Title:Soluble ST2, a preeclampsia-related cytokine receptor, is transported bi-directionally across the placenta.
[So] Source:Placenta;63:21-25, 2018 Mar.
[Is] ISSN:1532-3102
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: We aimed to elucidate whether soluble ST2 (sST2), a preeclampsia (PE)-related cytokine, in the maternal or fetal circulation could be transported to the other circulatory system across the placenta. METHODS: A placental perfusion model in a closed system was established and optimized. HPLC was performed to determine the dynamics of antipyrine levels in the perfusate. Placentas (n = 18) collected from healthy controls and PE patients were perfused without additional treatment or with added sST2 in the maternal or fetal circulation. The concentration of sST2 in the perfusate samples was quantified by ELISA. RESULTS: Monitoring of the antipyrine levels were used as a quality control and showed each placenta established successfully. In the untreated group, sST2 could be produced by the placenta and enter into both the maternal and fetal circulations, and significantly higher levels were detected in the maternal circulation. In placentas perfused with additional sST2 in the maternal circulation, a similar trend was observed as for the untreated placentas. When sST2 was added to the fetal circulation, increased sST2 was detected in the maternal circulation. Compared with the healthy controls, significantly elevated sST2 in the maternal side of PE patients were detected. CONCLUSION: Soluble ST2 could be bi-directionally transported across placentas. It was an active process that maintained a higher level of sST2 in the maternal circulation. Furthermore, the significant increase of sST2 in the maternal blood of PE patients was due to an impaired placental barrier as a result of PE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

  8 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29486850
[Au] Autor:Kulkarni A; Garcia-Caadilla P; Khan A; Lorenzo JM; Beckerman K; Valenzuela-Alcaraz B; Cruz-Lemini M; Gomez O; Gratacos E; Crispi F; Bijnens B
[Ad] Address:Division of Pediatric Cardiology, Bronx Lebanon Hospital Center, Bronx, NY, USA. Electronic address: aparnapat@yahoo.com.
[Ti] Title:Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: A fetal computational model analysis.
[So] Source:Placenta;63:1-6, 2018 Mar.
[Is] ISSN:1532-3102
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:AIMS: Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. METHODS: This was a multi-institutional study involving FMDM compared to fetuses of maternal controls (FC). Fetal echocardiographic Doppler data from left and right ventricular outflow tracts, aortic isthmus, middle cerebral and umbilical arteries were fitted into a validated fetal circulation computational model to estimate patient-specific placental and vascular properties. Non-parametric comparisons were made between resistances, compliances and flows in the brain and placenta in FMDM and FC. RESULTS: Data from 23 FMDM and 31 FC were fitted into the model. In FMDM, compared to FC, placental relative resistance was lower (0.59  0.50 versus 0.91  0.41; p < .05) with higher brain relative resistance (2.36  1.65 versus 1.60  0.85; p < .05). Middle cerebral artery flow was lower in FMDM than FC (0.12  0.14 vs. 0.27  0.21 ml/min; p 0.04) with a lower cerebral-placental flow ratio. Combined stroke volume was lower in FMDM (3.65  2.05 ml) than FC (4.97  2.45 ml) (p 0.04). CONCLUSIONS: Blood flow is redistributed in FMDM to the placenta, away from the brain. This alteration may play a role in the postnatal health of these fetuses.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

  9 / 5416 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29420606
[Au] Autor:Sweeney S; Adamcakova-Dodd A; Thorne PS; Assouline JG
[Ad] Address:Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States of America.
[Ti] Title:Multifunctional nanoparticles for real-time evaluation of toxicity during fetal development.
[So] Source:PLoS One;13(2):e0192474, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Increasing production of nanomaterials in industrial quantities has led to public health concerns regarding exposure, particularly among pregnant women and developing fetuses. Information regarding the barrier capacity of the placenta for various nanomaterials is limited due to challenges working with ex vivo human placentas or in vivo animal models. To facilitate real-time in vivo imaging of placental transport, we have developed a novel, multifunctional nanoparticle, based on a core of mesoporous silica nanoparticles (MSN), and functionalized for magnetic resonance imaging (MRI), ultrasound, and fluorescent microscopy. Our MSN particles were tested as a tracking method for harmful and toxic nanomaterials. In gravid mice, intravenous injections of MSN were administered in the maternal circulation in early gestation (day 9) and late gestation (day 14). MRI and ultrasound were used to track the MSN following the injections. Changes in contrast relative to control mice indicated that MSN were observed in the embryos of mice following early gestation injections, while MSN were excluded from the embryo by the placenta following late gestation injections. The timing of transplacental barrier porosity is consistent with the notion that in mice there is a progressive increasing segregation by the placenta in later gestation. In addition, built-in physico-chemical properties of our MSN may present options for the therapeutic treatment of embryonic exposure. For example, if preventive measures such as detoxification of harmful compounds are implemented, the particle size and exposure timing can be tailored to selectively distribute to the maternal side of the trophoblast or delivered to the fetus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0192474

  10 / 5416 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29352068
[Au] Autor:Li X; Yang X; Xiang E; Luo J; Qiu S; Fang Y; Zhang L; Guo Y; Zheng J; Wang H
[Ad] Address:Department of Pharmacology, School of Basic Medical Science, Wuhan University, Wuhan (X.L., E.X., J.L., S.Q., Y.F., Y.G., H.W.); and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan (Y.G., H.W.); Wuya College of Innovation, Shenyang Pharmaceutical Univer
[Ti] Title:Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats.
[So] Source:Drug Metab Dispos;46(4):422-428, 2018 Apr.
[Is] ISSN:1521-009X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pyrrolizidine alkaloids (PAs) are extensively synthesized by plants, are commonly present in herbs and foodstuffs, and exhibit hepatotoxicity requiring metabolic activation by cytochrome P450 3A to form the electrophilic metabolites-pyrrolic esters. PAs also cause embryo toxicity, but the metabolic profiles of PAs in fetus and placenta have been far from clear. In this study, we determined the basal metabolic activation of retrorsine (RTS) in rat maternal liver, placenta, and fetal liver in vitro and examined the fetal toxicity and bioactivation of RTS in vivo. Detection of microsomal RTS metabolites in vitro showed that the basal metabolic activity of fetal liver and placenta to RTS was much weaker than that of maternal liver. In addition, a higher rate of pyrrolic ester formation was found in normal male fetal liver compared with that of female pups. In vivo exposure to RTS caused fetal growth retardation, as well as placental and fetal liver injury. Little difference in serum RTS was observed in dams and fetuses, but the content of pyrrole-protein adduction in the fetal liver was much lower than that in maternal liver, which was consistent with basal metabolic activity. Unexpectedly, compared with basal metabolism in fetal liver, exposure to RTS during middle and late pregnancy caused an opposite gender difference in RTS metabolism and CYP3A expression in the fetal liver. For the first time, our study showed that RTS can permeate the placenta barrier and entering fetal circulation, whereas the intrauterine pyrrolic metabolite was generated mainly by fetal liver but not transported from the maternal circulation. Induction of CYP3A by RTS was gender-dependent in the fetal liver, which was probably responsible for RTS-induced fetal hepatic injury, especially for female pups.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Data-Review
[do] DOI:10.1124/dmd.117.079186


page 1 of 542 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information