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[PMID]: 29393481
[Au] Autor:Seo YS; Kang OH; Kong R; Zhou T; Kim SA; Ryu S; Kim HR; Kwon DY
[Ad] Address:Department of Oriental Pharmacy, College of Pharmacy, Wonkwang Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
[Ti] Title:Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer.
[So] Source:Oncol Rep;39(4):1702-1710, 2018 Apr.
[Is] ISSN:1791-2431
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) and it has a similar structure to platycodin D, which is a well known anticancer agent. In the present study, we investigated the anti-proliferative effects of PGD using NSCLC cell lines. We evaluated the effects of PGD on proliferation, apoptosis and cell cycle arrest in A549 and H460 cells. PGD significantly induced apoptosis and nuclear condensation in both cell lines. Furthermore, PGD upregulated the cleavage of apoptotic proteins such as caspase-3, -9 and PARP. Additionally, treatment with PGD suppressed the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2. Furthermore, PGD induced G0/G1-phase arrest in both cell lines. After treatment with PGD, the expression of TIMP-1, CDK2, cyclin A and cyclin E was reduced at the protein level. In addition, PGD blocked the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3ß, Akt and the expression of PI3K. Our results indicated that the anti-proliferative properties of PGD may result from the regulation of the PI3K/Akt pathway, which plays a critical role in cell survival and growth.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.3892/or.2018.6230

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[PMID]: 29486839
[Au] Autor:Qiu HW; Zhou QC; Geng J
[Ad] Address:Qingdao Agricultural University, Qingdao 266109, China. Electronic address: zhqch04@sdut.edu.cn.
[Ti] Title:Corrigendum to "Pyrolytic and kinetic characteristics of platycodon grandiflorum peel and its cellulose extract" [Carbohydr. Polym. 117 (6 march 2015) 644-649].
[So] Source:Carbohydr Polym;187:140, 2018 May 01.
[Is] ISSN:1879-1344
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:PUBLISHED ERRATUM
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

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[PMID]: 29287792
[Au] Autor:Kim YA; Oh SH; Lee GH; Hoa PT; Jin SW; Chung YC; Lee YC; Jeong HG
[Ad] Address:Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
[Ti] Title:Platycodon grandiflorum-derived saponin attenuates the eccentric exercise-induced muscle damage.
[So] Source:Food Chem Toxicol;112:150-156, 2018 Feb.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Platycodon grandiflorum contains triterpenoid saponins, such as platycodin D and platyconic acid A, and acts as a multifold nutritious compound. Our previous research demonstrated that Platycodon grandiflorum-derived saponin (PS) improves high-fat diet-induced non-alcoholic steatohepatitis and inhibits osteoclast differentiation. The pivotal effects of PS on inflammatory mechanism were suppressed NF-κB and matrix metalloproteinase (MMPs). However, the effects of PS on skeletal muscle damage remain unknown. Therefore, we investigated whether PS protects against eccentric exercise-induced muscle damage. A significant reduction in eccentric exercise-induced muscle damage area and muscle damage related to the level of NF-κB p65 by PS was associated with the downregulation of ERK/p38/SMAD signaling. Eccentric exercise caused muscle damage by increasing the serum lactate dehydrogenase (LDH), creatinine kinase (CK) and C-related protein level. The serum LDH, CK and C-related protein level was significantly lower in the PS supplementation group compared with the control group. Moreover, PS was inhibited MMP-1, MMP-2 and MMP-9. PS protects against eccentric exercise-induced muscle damage. Together, these results provide a novel perspective on the biological function of PS against muscle damage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:In-Process

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[PMID]: 29423591
[Au] Autor:Gao S; Satsu H; Makino T
[Ad] Address:Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.
[Ti] Title:Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in vitro.
[So] Source:J Nat Med;, 2018 Feb 08.
[Is] ISSN:1861-0293
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Bofutsushosan (BTS; fang feng tong sheng san in Chinese) is a formula in traditional Japanese Kampo medicine and Chinese medicine comprising eighteen crude drugs, and is used to treat obesity and metabolic syndrome. Fructose is contained in refreshing beverages as high-fructose corn syrup, and is associated with obesity. Fructose is absorbed via glucose transporter 5 (GLUT5) in the intestine. Therefore, the inhibition of GLUT5 is considered to be a target of obesity drugs. We evaluated the inhibitory effects of BTS extract and its constituents on fructose uptake using Chinese hamster ovary K1 cells, i.e., cells stably expressing GLUT5. Boiled water extract of BTS significantly suppressed GLUT5 function in a concentration-dependent manner without cytotoxicities. Among 18 components of BTS, the boiled water extracts of the rhizome of Zingiber officinale, the root and rhizome of Saposhnikovia divaricata, and the root of Platycodon grandiflorum exhibited significant inhibitory effects on fructose uptake with IC values of 314, 119 and 475 µg/ml, respectively. Among the constituents of the rhizome of Z. officinale extract, 6-gingerol significantly inhibited GLUT5 with an IC value of 39 µM, while 6-shogaol exhibited a significant but weak inhibition on GLUT5 at 100 µM. One of the mechanisms of action of BTS may be the inhibition of fructose absorption in the intestine, and one of the active components of BTS is the rhizome of Z. officinale and 6-gingerol.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher
[do] DOI:10.1007/s11418-018-1183-0

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[PMID]: 29150928
[Au] Autor:Chen B; Liu Z; Zhang Y; Li W; Sun Y; Wang Y; Wang Y; Sun Y
[Ad] Address:Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Jilin, P. R. China.
[Ti] Title:Application of high-speed counter-current chromatography and HPLC to separate and purify of three polyacetylenes from Platycodon grandiflorum.
[So] Source:J Sep Sci;, 2017 Nov 18.
[Is] ISSN:1615-9314
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Three polyacetylenes were isolated and purified from Platycodon grandiflorum A. DC for the first time by high-speed counter-current chromatography using a two-phase solvent system composed of hexane/ethyl acetate/methanol/water (1:31:1:31, v/v/v/v) and high-performance liquid chromatography with an Agilent ZORBAX SB-C18 column (4.6 mm × 150 mm, 5 µm). After separation by high-speed counter-current chromatography and high-performance liquid chromatography, we obtained 3.5 mg of platetyolin A, 4.1 mg of platetyolin B, and 18.1 mg of lobetyolin with purities of 97.2, 96.7, and 96.9%, respectively. The purity of each compound was assessed by high-performance liquid chromatography and the chemical structures were evaluated by high-resolution electrospray ionization time-of-flight mass spectrometry and one- and two-dimensional NMR spectroscopy. Among the isolated compounds, platetyolin A and platetyolin B are newly reported compounds. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171118
[Lr] Last revision date:171118
[St] Status:Publisher
[do] DOI:10.1002/jssc.201700767

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[PMID]: 29112148
[Au] Autor:Zhao X; Wang Y; Yan P; Cheng G; Wang C; Geng N; Wang X; Liu J
[Ad] Address:College of Animal Medicine and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China. zhaoxn@sdau.edu.cn.
[Ti] Title:Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro.
[So] Source:Molecules;22(11), 2017 Nov 07.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The study is aimed at investigating the immunoenhancement activity of polysaccharides from polysaccharides (PGPSs) in vitro. In this study, some research on lymphocyte proliferation, cell cycle, and the levels of CD4⁺ and CD8⁺ T cells were performed. Four different concentrations of PGPSs (PGPS , PGPS , PGPS , and PGPS ) were harvested and added to peripheral blood T lymphocytes. We observed significant increases in T lymphocyte proliferation at PGPS groups individually or synergistically with phytohemagglutinin (PHA) at most concentrations, and their lymphocyte proliferation rates were the highest. The active sites of PGPS and PGPS were subsequently chosen. Then, we utilized flow cytometry to determine lymphocyte cell cycle distribution and levels of CD4⁺ and CD8⁺ T cells. At most time points, PGPS could facilitate lymphocyte cell cycle progression from the G0/G1 phase to the S and G2/M phases and, simultaneously, increase the levels of CD4⁺ and CD8⁺ T cells. These results indicate that PGPS enhances the immune functions, suggesting that PGPS could be a potential immunopotentiator for further in vivo and clinical trial experiments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:In-Process

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[PMID]: 29082708
[Au] Autor:Wang PL; Fan YH; Fan XS; Wang CJ
[Ad] Address:College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
[Ti] Title:[Compatible principles of Xiebai decoction family based on complex network analysis].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(9):1787-1791, 2017 May.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:In order to explore the compatible principles of Xiebai decoction family, formulae from ancient and modern Xiebai decoction family were collected and sorted in this study. The compatible characteristics, core herbs, as well as the relativity of herbs nature in Xiebai decoction family were analyzed based on scale free network and other data-mining methods such as association rules, clustering analysis and correspondence analysis. The scale free network results showed that in Xiebai decoction family, Mori Cortex-Lycii Cortex-Glycyrrhizae Radix et Rhizoma was used as the core compatible group and formed the complicated compatible network with other additional herbs; association rules results showed that the core herbs in such formulae included Mori Cortex, Lycii Cortex, Glycyrrhizae Radix et Rhizoma, scutellaria root, Platycodon root, Anemarrhena, and almond, which formed corresponding herbal pairs and compatibility; clustering analysis showed that Mori Cortex was the core herb in Xiebai decoction family, and Mori Cortex-Lycii Cortex-Glycyrrhizae Radix et Rhizoma was its main combination unit, which was always compatible with herbs of clearing heat, reducing phlegm, supplementing Qi and nourishing Yin to form the series prescriptions. The results indicated that the core compatibility features of Xiebai decoction family were clearing heat in lung and relieving cough and asthma, providing a basis for the clinical application of Xiebai decoction family.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process
[do] DOI:10.19540/j.cnki.cjcmm.20170224.005

  8 / 286 MEDLINE  
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[PMID]: 29082682
[Au] Autor:Lu HY; Peng HS; Gui SY; Peng DY
[Ad] Address:Anhui University of Chinese Medicine, Hefei 230012, China.
[Ti] Title:[Evolution and transition of quality evaluation of Platycodon grandiflorum].
[So] Source:Zhongguo Zhong Yao Za Zhi;42(9):1637-1640, 2017 May.
[Is] ISSN:1001-5302
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Platycodon grandiflorum, a traditional Chinese medicine commonly used for coughing and eliminating phlegm to relieve asthma, has gained great attention to its quality evaluation in ancient and modern herbal books. This paper investigated the methods of quality evaluation in the ancient herbal books systematically, and the results showed that there were bitter and sweet P. grandiflorum, south and north P. grandiflorum. Those distributed in east China were called south P. grandiflorum, with bitter taste; and those distributed in north China, northeast China were called north P. grandiflorum, with sweet taste. There was a common sense that P. grandiflorum with a bitter taste had good quality in the ancient herbal books, namely those produced in east China. P. grandiflorum of better quality were characterized by thicker and longer root, white color, solid texture and bitter taste in properties. In addition, the quality of P. grandiflorum was also affected by its germplasm, collecting and processing. This paper summarized the formation and development of the "assessing the quality by distinguishing features of traditional Chinese medicinal materials" views of P. grandiflorum, providing the herbalism basis for its present quality evaluation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process
[do] DOI:10.19540/j.cnki.cjcmm.20170121.033

  9 / 286 MEDLINE  
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[PMID]: 28852980
[Au] Autor:Kwon J; Lee H; Kim N; Lee JH; Woo MH; Kim J; Kim YS; Lee D
[Ad] Address:Natural Constituents Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, 25451, Korea.
[Ti] Title:Effect of processing method on platycodin D content in Platycodon grandiflorum roots.
[So] Source:Arch Pharm Res;40(9):1087-1093, 2017 Sep.
[Is] ISSN:0253-6269
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC-ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC-ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:In-Process
[do] DOI:10.1007/s12272-017-0946-6

  10 / 286 MEDLINE  
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[PMID]: 28830541
[Au] Autor:Hao W; Liu S; Qin Y; Sun C; Chen L; Wu C; Bao Y
[Ad] Address:Department of Breast Surgery (Integrated Traditional and Western Medicine), Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Xuhui District, Shanghai, 200032, China.
[Ti] Title:Cardioprotective effect of Platycodon grandiflorum in patients with early breast cancer receiving anthracycline-based chemotherapy: study protocol for a randomized controlled trial.
[So] Source:Trials;18(1):386, 2017 Aug 22.
[Is] ISSN:1745-6215
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Anthracyclines, alone or in combination with other drugs, are among the most effective chemotherapeutic agents to treat breast cancer both in the adjuvant and neoadjuvant setting. Unfortunately, anthracycline-associated dose-dependent cardiotoxicity is a limiting factor in clinical use. Extensive efforts have been devoted to identifying strategies to prevent anthracycline-induced cardiotoxicity. However, most cardioprotective agents have shown little effect in clinical trials. Herbal medicines are pure, natural substances that have been used for centuries in many countries, including China. This trial aims to evaluate the cardioprotective effects and safety of Platycodon grandiflorum granules compared to placebo granules in patients with early breast cancer receiving anthracycline-based chemotherapy. METHOD/DESIGN: This study is a single-center, double-blinded, randomized, placebo-controlled, parallel-group trial. A total of 120 patients will be randomly allocated in a 1:1 ratio to receive either P. grandiflorum granules or placebo granules twice daily for 12 weeks. The primary outcome is heart failure (either clinical or subclinical). The secondary outcomes include all-cause mortality, cardiac death, electrocardiogram (ECG) findings, left ventricular diastolic function, longitudinal systolic strain and velocities measured by tissue Doppler imaging, cardiac biomarkers, such as troponin I (TnI), brain natriuretic peptide (BNP), and creatine kinase isoenzymes (CK-MB). Assessments will be performed at baseline (before randomization) and 3, 6, 9, 12, 16, and 20 weeks after randomization. DISCUSSION: This will be the first clinical trial to evaluate the cardioprotective effects and safety of P. grandiflorum in patients with early breast cancer receiving anthracycline-based chemotherapy. We are also performing this trial to assess the feasibility of a larger-scale clinical trial in the future. TRAIL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR-IPR-16009256 . Registered on 23 September 2016.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170831
[Lr] Last revision date:170831
[St] Status:In-Process
[do] DOI:10.1186/s13063-017-2140-z


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