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[PMID]: 29478915
[Au] Autor:Chen KS; Xu M; Zhang Z; Chang WC; Gaj T; Schaffer DV; Dan Y
[Ad] Address:Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
[Ti] Title:A Hypothalamic Switch for REM and Non-REM Sleep.
[So] Source:Neuron;97(5):1168-1176.e4, 2018 Mar 07.
[Is] ISSN:1097-4199
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Rapid eye movement (REM) and non-REM (NREM) sleep are controlled by specific neuronal circuits. Here we show that galanin-expressing GABAergic neurons in the dorsomedial hypothalamus (DMH) comprise separate subpopulations with opposing effects on REM versus NREM sleep. Microendoscopic calcium imaging revealed diverse sleep-wake activity of DMH GABAergic neurons, but the galanin-expressing subset falls into two distinct groups, either selectively activated (REM-on) or suppressed (REM-off) during REM sleep. Retrogradely labeled, preoptic area (POA)-projecting galaninergic neurons are REM-off, whereas the raphe pallidus (RPA)-projecting neurons are primarily REM-on. Bidirectional optogenetic manipulations showed that the POA-projecting neurons promote NREM sleep and suppress REM sleep, while the RPA-projecting neurons have the opposite effects. Thus, REM/NREM switch is regulated antagonistically by DMH galaninergic neurons with intermingled cell bodies but distinct axon projections.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review

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[PMID]: 29516253
[Au] Autor:Meng X; Ai Y; Li R; Zhang W
[Ad] Address:Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science, Sichuan University, Chengdu, Sichuan, China.
[Ti] Title:Effects of heavy metal pollution on enzyme activities in railway cut slope soils.
[So] Source:Environ Monit Assess;190(4):197, 2018 Mar 07.
[Is] ISSN:1573-2959
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Railway transportation is an important transportation mode. However, railway transportation causes heavy metal pollution in surrounding soils. Heavy metal pollution has a serious negative impact on the natural environment, including a decrease of enzyme activities in soil and degradation of sensitive ecosystems. Some studies investigated the heavy metal pollution at railway stations or certain transportation hubs. However, the pollution accumulated in artificial cut slope soil all along the rails is still questioned. The interest on non-point source pollution from railways is increasing in an effort to protect the soil quality along the line. In this study, we studied spatial distributions of heavy metals and five enzyme activities, i.e., urease (UA), saccharase (SAC), protease (PRO), catalase (CAT), and polyphenol oxidase (POA) in the soil, and the correlation among them beside three different railways in Sichuan Province, China, as well. Soil samples were respectively collected from 5, 10, 25, 50, 100, and 150 m away from the rails (depth of 0-8 cm). Results showed that Mn, Cd, Cu, and Zn were influenced by railway transportation in different degrees while Pb was not. Heavy metal pollution was due to the abrasion of the gravel bed as well as the tracks and freight transportation which caused more heavy metal pollution than passenger transportation. Enzymatic activities were significantly negatively correlated with heavy metals in soils, especially Zn and Cu. Finally, it is proposed that combined use of PRO and POA activities could be an indicator of the heavy metal pollution in cut slope soils. The protective measures aimed at heavy metal pollution caused by railway transportation in cut slope soils are urgent.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Process
[do] DOI:10.1007/s10661-018-6567-9

  3 / 2548 MEDLINE  
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[PMID]: 29300938
[Au] Autor:Elsamadicy AA; Sergesketter A; Sampson JH; Gottfried ON
[Ad] Address:Department of Neurosurgery, Duke Uni- versity Medical Center, Durham, North Carolina.
[Ti] Title:Institutional Review of Mortality in 5434 Consecutive Neurosurgery Patients: Are We Improving?
[So] Source:Neurosurgery;, 2017 Dec 28.
[Is] ISSN:1524-4040
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Despite increasing emphasis on quality improvement in neurosurgery, few studies have evaluated the impact of quality initiatives on health-assessment metrics including risk of mortality (ROM), severity of illness (SOI), case mix index (CMI), and mortality index. OBJECTIVE: To evaluate the impact of a multifactorial quality initiative on mortality and quality metrics on a neurosurgical service. METHODS: Records of 5434 consecutive neurosurgery inpatients and consults including all inpatient mortalities were prospectively collected and reviewed from July 2014 to June 2016 at major academic institution. A multifactorial quality improvement intervention was implemented in July 2015. UHC risk models mortality index, CMI, ROM, SOI present on admission (POA), and at hospital discharge (DC) were compared in the prior 12 mo and the 12 m after implementation. For mortality cases, diagnosis-related group codes, procedure type, and etiology of mortality were collected. RESULTS: Compared to the pre-intervention cohort (n = 2793), the postintervention cohort (n = 2641) trended to have a decreased mean-observed monthly mortality (3.08 vs 4.17) and mean-monthly mortality index (0.73 vs 0.98). Additionally, the postintervention cohort had significantly higher CMI (3.14 vs 2.96, P = .02), POA-ROM (1.52 vs 1.46, P = .02), POA-SOI (1.97 vs 1.84, P = .0002), DC-ROM (1.69 vs 1.58, P = .003), and DC-SOI (2.1 vs 1.95, P < .0001). Of 131 mortalities (pre-intervention: n = 70, postintervention: n = 61), the postintervention cohort had a higher proportion of moralities due to emergent and trauma admissions than elective. CONCLUSION: Our study suggests that our quality initiative impacted observed mortality, improved documentation, and enhanced overall quality of care on a neurosurgical service.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/neuros/nyx603

  4 / 2548 MEDLINE  
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[PMID]: 29215266
[Au] Autor:Chen C; Liu J; Halpert JR; Wilderman PR
[Ad] Address:University of Connecticut School of Pharmacy , Storrs, Connecticut 06269, United States.
[Ti] Title:Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes.
[So] Source:Biochemistry;57(5):817-826, 2018 Feb 06.
[Is] ISSN:1520-4995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human hepatic cytochromes P450 (CYP) are integral to xenobiotic metabolism. CYP2B6 is a major catalyst of biotransformation of environmental toxicants, including polybrominated diphenyl ethers (PBDEs). CYP2B substrates tend to contain halogen atoms, but the biochemical basis for this selectivity and for species specific determinants of metabolism has not been identified. Spectral binding titrations and inhibition studies were performed to investigate interactions of rat CYP2B1, rabbit CYP2B4, and CYP2B6 with a series of phenoxyaniline (POA) congeners that are analogues of PBDEs. For most congeners, there was a <3-fold difference between the spectral binding constants (K ) and IC values. In contrast, large discrepancies between these values were observed for POA and 3-chloro-4-phenoxyaniline. CYP2B1 was the enzyme most sensitive to POA congeners, so the Val-363 residue from that enzyme was introduced into CYP2B4 or CYP2B6. This substitution partially altered the protein-ligand interaction profiles to make them more similar to that of CYP2B1. Addition of cytochrome P450 oxidoreductase (POR) to titrations of CYP2B6 with POA or 2'4'5'TCPOA decreased the affinity of both ligands for the enzyme. Addition of cytochrome b to a recombinant enzyme system containing POR and CYP2B6 increased the POA IC value and decreased the 2'4'5'TCPOA IC value. Overall, the inconsistency between K and IC values for POA versus 2'4'5'TCPOA is largely due to the effects of redox partner binding. These results provide insight into the biochemical basis of binding of diphenyl ethers to human CYP2B6 and changes in CYP2B6-mediated metabolism that are dependent on POA congener and redox partner identity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.biochem.7b01024

  5 / 2548 MEDLINE  
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[PMID]: 29478718
[Au] Autor:Woodworth HL; Brown JA; Batchelor HM; Bugescu R; Leinninger GM
[Ad] Address:Department of Physiology, Michigan State University, East Lansing, MI, USA.
[Ti] Title:Determination of neurotensin projections to the ventral tegmental area in mice.
[So] Source:Neuropeptides;, 2018 Feb 15.
[Is] ISSN:1532-2785
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Pharmacologic treatment with the neuropeptide neurotensin (Nts) modifies motivated behaviors such as feeding, locomotor activity, and reproduction. Dopamine (DA) neurons of the ventral tegmental area (VTA) control these behaviors, and Nts directly modulates the activity of DA neurons via Nts receptor-1. While Nts sources to the VTA have been described in starlings and rats, the endogenous sources of Nts to the VTA of mice remain incompletely understood, impeding determination of which Nts circuits orchestrate specific behaviors in this model. To overcome this obstacle we injected the retrograde tracer Fluoro-Gold into the VTA of mice that express GFP in Nts neurons. Identification of GFP-Nts cells that accumulate Fluoro-Gold revealed the Nts afferents to the VTA in mice. Similar to rats, most Nts afferents to the VTA of mice arise from the medial and lateral preoptic areas (POA) and the lateral hypothalamic area (LHA), brain regions that are critical for coordination of feeding and reproduction. Additionally, the VTA receives dense input from Nts neurons in the nucleus accumbens shell (NAsh) of mice, and minor Nts projections from the amygdala and periaqueductal gray area. Collectively, our data reveal multiple populations of Nts neurons that provide direct afferents to the VTA and which may regulate specific aspects of motivated behavior. This work lays the foundation for understanding endogenous Nts actions in the VTA, and how circuit-specific Nts modulation may be useful to correct motivational and affective deficits in neuropsychiatric disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher

  6 / 2548 MEDLINE  
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[PMID]: 29478647
[Au] Autor:Yan J; Chen L; Lin Q; Zhao S; Li L
[Ad] Address:Key Laboratory of Global Change and Marine-Atmospheric Chemistry, Third Institute of Oceanography, SOA, Xiamen 361005, China. Electronic address: jpyan@tio.org.cn.
[Ti] Title:Pollutants identification of ambient aerosols by two types of aerosol mass spectrometers over southeast coastal area, China.
[So] Source:J Environ Sci (China);64:252-263, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Two different aerosol mass spectrometers, Aerodyne Aerosol Mass Spectrometer (AMS) and Single Particle Aerosol Mass Spectrometer (SPAMS) were deployed to identify the aerosol pollutants over Xiamen, representing the coastal urban area. Five obvious processes were classified during the whole observation period. Organics and sulfate were the dominant components in ambient aerosols over Xiamen. Most of the particles were in the size range of 0.2-1.0µm, accounting for over 97% of the total particles measured by both instruments. Organics, as well as sulfate, measured by AMS were in good correlation with measured by SPAMS. However, high concentration of NH was obtained by AMS, while extremely low value of NH was detected by SPAMS. Contrarily, high particle number counts of NO and Cl were given by SPAMS while low concentrations of NO and Cl were measured by AMS. The variations of POA and SOA obtained from SPAMS during event 1 and event 2 were in accordance with the analysis of HOA and OOA given by AMS, suggesting that both of AMS and SPAMS can well identify the organic clusters of aerosol particles. Overestimate or underestimate of the aerosol sources and acidity would be present in some circumstances when the measurement results were used to analyze the aerosol properties, because of the detection loss of some species for both instruments.
[Mh] MeSH terms primary: Aerosols/analysis
Air Pollutants/analysis
Environmental Monitoring/instrumentation
Particulate Matter/analysis
[Mh] MeSH terms secundary: China
Particle Size
Sulfates/analysis
Sulfur Oxides/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Aerosols); 0 (Air Pollutants); 0 (Particulate Matter); 0 (Sulfates); 0 (Sulfur Oxides)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:180227
[St] Status:MEDLINE

  7 / 2548 MEDLINE  
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[PMID]: 29267849
[Au] Autor:Yang R; Sun HH; Ji CL; Zhang J; Yuan HJ; Luo MJ; Liu XY; Tan JH
[Ad] Address:College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an City, P. R. China.
[Ti] Title:Role of calcium-sensing receptor in regulating spontaneous activation of postovulatory aging rat oocytes.
[So] Source:Biol Reprod;98(2):218-226, 2018 Feb 01.
[Is] ISSN:1529-7268
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mechanisms for postovulatory aging (POA) of oocytes and for spontaneous activation (SA) of rat oocytes are largely unknown. Expression of calcium-sensing receptor (CaSR) in rat oocytes and its role in POA remain unexplored. In this study, expression of CaSR in rat oocytes aging for different times was detected by immunofluorescence microscopy, and western blotting and the role of CaSR in POA was determined by observing the effects of regulating its activity on SA susceptibility and cytoplasmic calcium levels. The results showed that CaSR was expressed in rat oocytes. Oocytes recovered 19 h post human chorionic gonadotropin (hCG) injection were more susceptible to SA and expressed more functional CaSR than oocytes recovered 13 h after hCG injection, although both expressed the same level of total CaSR protein. Treatment with CaSR antagonist significantly suppressed cytoplasmic calcium elevation and SA of oocytes. Activation of Na-Ca2+ exchanger with NaCl inhibited SA to a greater extent than suppression of CaSR with NPS-2143, suggesting that calcium sources other than CaSR-controlled channels contributed to the elevation of cytoplasmic calcium. Treatment with T- or L-type calcium channel blockers significantly reduced SA. Suppression of all calcium channels tested reduced SA to minimum. It is concluded that the level of CaSR functional dimer protein, but not that of the total CaSR protein, was positively correlated with the SA susceptibility during POA of rat oocytes confirming that CaSR is involved in POA regulation. Blocking multiple calcium channels might be a better choice for efficient control of SA in rat oocytes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Data-Review
[do] DOI:10.1093/biolre/iox178

  8 / 2548 MEDLINE  
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[PMID]: 29253592
[Au] Autor:Jiang L; Wang H; Chen G; Feng Y; Zou J; Liu M; Liu K; Wang N; Zhang H; Wang K; Xiao X
[Ad] Address:Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, PR China.
[Ti] Title:WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells.
[So] Source:Free Radic Biol Med;117:58-65, 2017 Dec 15.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:MIP2, one of WDR26 isoforms, encodes a 498 amino acid protein with an amino-terminal CTLH domain and five carboxyl-terminal WD40 motifs. MIP2 is localized to the mitochondria and protects cardiomyocytes against oxidative stress; however, nothing is known about how MIP2 confers its cytoprotection. Using co-immunoprecipitation (co-IP) method to isolate MIP2-protein complex from Sprague -Dawley rat heart, followed by mass spectrometry analysis, we have identified VDAC1, a protein located at mitochondria, as a novel MIP2-interacting protein in the myocardium of rat hearts as well as H9c2 cells. This interaction was further confirmed by co-IP assays in the myocardial tissues and H9c2 cardiomyocytes, and by protein overlay assay (POA) in vitro. It was shown that MIP2 overexpression alleviated the H O -induced increase of VDAC1 and cell damage, and MIP2 deficiency aggravated the increase of VDAC1 and cell damage in H O -treated H9c2 cells. Our research suggests that the protective effect of MIP2 on the cardiomyocytes against oxidative stress is partly associated with its interaction with VDAC1 and thus inhibiting its expression.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:Publisher

  9 / 2548 MEDLINE  
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[PMID]: 29202632
[Au] Autor:Ödquist M; Hallberg K; Rahme H; Salomonsson B; Rosso A
[Ad] Address:a Ortho Center Stockholm , Löwenströmska sjukhuset , Stockholm.
[Ti] Title:Lower age increases the risk of revision for stemmed and resurfacing shoulder hemi arthroplasty.
[So] Source:Acta Orthop;89(1):3-9, 2018 Feb.
[Is] ISSN:1745-3682
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background and purpose - The number of patients where shoulder hemiarthroplasty (SHA) is an option is still substantial. Descriptive analyses performed by the Swedish Shoulder Arthroplasty Registry (SSAR) showed that while patients receiving SHA designs, i.e. resurfacing hemi (RH) and stemmed hemi (SH), reported similar shoulder functionality and quality of life, the revision rate for RH (12%) was larger than for SH (6.7%); this difference was studied. Patients and methods - All primary SHA (n = 1,140) for OA reported to SSAR between 1999 and 2009 were analyzed regarding risk factors for revision and PROM outcome, 950 shoulders with primary OA (POA), and 190 secondary OA (SOA). Mean age was 67.4 years (SD 10.8). PROM including WOOS and EQ-5D were collected at 5 years, until December 31, 2014. Results - 76/950 prostheses because of POA and 16/190 prosthesis because of SOA were revised. Age at primary surgery was the main factor that influenced the risk of revision, lower age increased the risk of revision, and was also the explanation for the difference between SH and RH. We also found that SH and RH had similar outcomes measured by PROM, but the POA group had higher scores than the SOA group with a clinically relevant difference of 10% in WOOS. Interpretation - The risk of revision for SH and RH is similar when adjusted for age and does not depend on primary diagnosis or sex. A lower age increases the risk of revision. Patients suffering from POA experience better shoulder functionality than SOA patients irrespective of implant type.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Data-Review
[do] DOI:10.1080/17453674.2017.1411081

  10 / 2548 MEDLINE  
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[PMID]: 29447477
[Au] Autor:Li CH; Bai YL; Chen YC
[Ad] Address:a Department of Applied Chemistry , National Chiao Tung University , Hsinchu , Taiwan.
[Ti] Title:Inhibition of the lethality of Shiga-like toxin-1 by functional gold nanoparticles.
[So] Source:Artif Cells Nanomed Biotechnol;:1-11, 2018 Feb 15.
[Is] ISSN:2169-141X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Escherichia coli O157:H7 is a pathogen, which can generate Shiga-like toxins (SLTs) and cause hemolytic-uremic syndrome. Foodborne illness outbreaks caused by E. coli O157:H7 have become a global issue. Since SLTs are quite toxic, effective medicines that can reduce the damage caused by SLTs should be explored. SLTs consist of a single A and five B subunits, which can inhibit ribosome activity for protein synthesis and bind with the cell membrane of host cells, respectively. Pigeon ovalbumin (POA), i.e. a glycoprotein, is abundant in pigeon egg white (PEW) proteins. The structure of POA contains Gal-α(1→4)-Gal-ß(1→4)-GlcNAc ligands, which have binding affinity toward the B subunit in SLT type-1 (SLT-1B). POA immobilized gold nanoparticles (POA-Au NPs) can be generated by reacting PEW proteins with aqueous tetrachloroauric acid in one-pot. The generated POA-Au NPs have been demonstrated to have selective trapping-capacity toward SLT-1B previously. Herein, we explore that POA-Au NPs can be used as protective agents to neutralize the toxicity of SLT-1 in SLT-1-infected model cells. The results show that the cells can be completely rescued when a sufficient amount of POA-Au NPs is used to treat the SLT-1-infected cells within 1 h.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:Publisher
[do] DOI:10.1080/21691401.2018.1438449


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