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[PMID]: 29331967
[Au] Autor:Gwyther H; Shaw R; Jaime Dauden EA; D'Avanzo B; Kurpas D; Bujnowska-Fedak M; Kujawa T; Marcucci M; Cano A; Holland C
[Ad] Address:Aston Research Centre for Healthy Ageing (ARCHA), Psychology, School of Life and Health Sciences, Aston University, Birmingham, UK.
[Ti] Title:Understanding frailty: a qualitative study of European healthcare policy-makers' approaches to frailty screening and management.
[So] Source:BMJ Open;8(1):e018653, 2018 01 13.
[Is] ISSN:2044-6055
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To elicit European healthcare policy-makers' views, understanding and attitudes about the implementation of frailty screening and management strategies and responses to stakeholders' views. DESIGN: Thematic analysis of semistructured qualitative interviews. SETTING: European healthcare policy departments. PARTICIPANTS: Seven European healthcare policy-makers representing the European Union (n=2), UK (n=2), Italy (n=1), Spain (n=1) and Poland (n=1). Participants were sourced through professional networks and the European Commission Authentication Service website and were required to be in an active healthcare policy or decision-making role. RESULTS: Seven themes were identified. Our findings reveal a 'knowledge gap', around frailty and which has resulted in restricted by specialists. Policy-makers emphasised the need to recognise frailty as a clinical syndrome but stressed that it should be managed via an integrated and interdisciplinary response to chronicity and ageing. That is, through social co-production. This would require a with redeployment of existing resources to deliver frailty management and intervention services. Policy-makers proposed indicating a need to be innovative with solutions to empower older adults to optimise their health and well-being, while still fully engaging in the social environment. The theme described the complexities of institutional change management, as well as cultural issues relating to working democratically, while in , the need for a personal navigator to help older adults to access appropriate services was proposed. Policy-makers also believed that could be an effective tool for frailty management. CONCLUSIONS: There is potential for frailty to be managed in a more integrated and person-centred manner, overcoming the challenges associated with niche ownership within the healthcare system. There is also a need to raise its profile and develop a common understanding of its malleability among stakeholders, as well as consistency in how and when it is measured.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process
[do] DOI:10.1136/bmjopen-2017-018653

  2 / 20939 MEDLINE  
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[PMID]: 29521328
[Au] Autor:Schneider A; Krauze T; Minczykowski A; Dziarmaga M; Piskorski J; Szczepanik A; Banaszak A; Guzik P; Wykretowicz A
[Ti] Title:Arterial excess-reservoir pressure integral as a predictor of cardiovascular complications in subjects with acute coronary syndrome.
[So] Source:Pol Arch Intern Med;, 2018 Mar 09.
[Is] ISSN:1897-9483
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION    The excess pressure-time integral (excessPTI) and the reservoir pressure-time integral (reservoirPTI) are new metrics derived from blood pressure (BP) waveform decomposition. These markers predict cardiovascular (CV) complications and are associated with target organ damage in treated hypertensive patients or subjects with chronic and acute heart failure. OBJECTIVES    Herein we investigated whether reservoirPTI or excessPTI predict future CV events (death, stroke, myocardial infarction) in subjects with acute coronary syndrome (ACS) and diminished ejection fraction (EF).  PATIENTS AND METHODS    BP waveforms were obtained by radial tonometry in 251 subjects with ACS (median age 64 years) and diminished EF (median 40%). Left ventricular EF was assessed by transthoracic echocardiography. ReservoirPTI and excessPTI were derived by decomposition of the BP waveform.  RESULTS    In all, 78 CV events (death, stroke, myocardial infarction) occurred during the follow-up period (median 1245 days). Kaplan-Meier analysis showed that the highest tertile of excessPTI was a significant predictor of adverse outcome. Multivariate Cox analysis demonstrated that excessPTI was a significant predictor of CV events after adjustment for EF, age, history of stroke, myocardial infarction and coronary artery bypass grafting [hazard ratio 1.9; 95% confidence interval 1.1-3.3; P = 0.02)].  CONCLUSIONS    In conclusion, excessPTI, a new metric derived from reservoir-pressure analysis, predicts outcome in survivors of ACS with diminished EF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.20452/pamw.4222

  3 / 20939 MEDLINE  
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[PMID]: 29521067
[Au] Autor:Jez W; Tobiasz-Adamczyk B; Brzyski P; Majkowicz M; Pankiewicz P; Irzyniec TJ
[Ad] Address:Outpatient Clinic for Women with Turner Syndrome, Specialist Hospital No. 2, Bytom, Poland.
[Ti] Title:Social and medical determinants of quality of life and life satisfaction in women with Turner syndrome.
[So] Source:Adv Clin Exp Med;27(2):229-236, 2018 Feb.
[Is] ISSN:1899-5276
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Turner syndrome (TS) appears in women as a result of the lack of part or the whole of one of the X chromosomes. It is characterized by the occurrence of low height, hypogonadism, numerous developmental defects, and is often accompanied by psychological disturbances. OBJECTIVES: Although the phenotype characteristics of women with TS are quite well documented, the knowledge of the impact of Turner syndrome on the satisfaction with life is still insufficient. The aim of our study was to assess the impact of TS on selected variables of quality of life, and hence also life satisfaction in women with this syndrome. MATERIAL AND METHODS: The research was carried out in a group of 176 women with TS starting March 1995. The patients underwent anthropological and medical examinations, and their medical histories were taken using a questionnaire that included demographic and psychosocial items as well as issues related to selected variables of quality of life. In our research model, general life satisfaction was a dependent variable. The statistical analysis was conducted using the eta and Cramer's V correlation coefficients as well as a multidimensional logistic regression model. RESULTS: The main determinants of dissatisfaction with life in women with TS were short stature and feelings of loneliness and being handicapped. CONCLUSIONS: The determinants of life satisfaction in women with Turner syndrome were closely related to the private life of the study participants, in particular self-perception and feelings concerning their health status.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.17219/acem/66986

  4 / 20939 MEDLINE  
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[PMID]: 29521057
[Au] Autor:Tonyali S; Ates D; Akbiyik F; Kankaya D; Baydar D; Ergen A
[Ad] Address:Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
[Ti] Title:Urine nerve growth factor (NGF) level, bladder nerve staining and symptom/problem scores in patients with interstitial cystitis.
[So] Source:Adv Clin Exp Med;27(2):159-163, 2018 Feb.
[Is] ISSN:1899-5276
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a challenging disease, affecting thousands of people all around the world, especially women. Although there have been numerous theories regarding IC/BPS etiology, the physiopathology of the disease still remains unclear and there is a lack of certain treatment. OBJECTIVES: The aim of the study was to assess the role of nerve fibers and nerve growth factor (NGF) in the etiopathogenesis of IC/BPS symptoms by demonstrating if there is a correlation between urine NGF levels, amount of peripheral nerves in bladder mucosa and symptom severity. MATERIAL AND METHODS: A prospective clinical study was conducted with 15 IC/BPS patients and 18 controls. Urine NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). Bladder punch biopsies were obtained from 15 IC/BPS patients and 9 controls. Immunohistochemistry was performed for S-100 to highlight peripheral nerve twigs in bladder mucosa. The O'Leary-Sant Interstitial Cystitis Symptom and Problem Index (OSICSPI) was used to assess symptom severity and effects of the disease on the patients' life. RESULTS: NGF normalized to urine creatinine (NGF/Cr) levels in IC/BPS patients were significantly higher than in controls, 0.34 ±0.22 and 0.09 ±0.08 pg/mL: mg/dL, respectively (p < 0.001). The mean symptom score in IC patients was 12.27 ±2.4 (median: 12) and the mean problem score was 10.9 ±2.3 (median: 12). The mean mucosal nerve (S-100 stained) area in the IC/BPS group was significantly higher than in the controls, 2.53 ±1.90 vs 1.0 ±0.70, respectively (p = 0.018). In correlation analyses, the NGF/Cr level in IC/BPS patients was found significantly correlated with the O'Leary-Sant IC Symptom and Problem Index scores independently (p = 0.001 and p = 0.028, respectively). CONCLUSIONS: NGF seems to be a promising biomarker in IC/BPS. It may help clinicians in diagnoses and patient follow-up. Thus, unnecessary, expensive and invasive tests, interventions and treatments might be avoided.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.17219/acem/69231

  5 / 20939 MEDLINE  
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[PMID]: 29521045
[Au] Autor:Eren Y; Yavasoglu NG; Comoglu SS
[Ad] Address:Department of Neurology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
[Ti] Title:The relationship between QDASH scale and clinical, electrophysiological findings in carpal tunnel syndrome.
[So] Source:Adv Clin Exp Med;27(1):71-75, 2018 Jan.
[Is] ISSN:1899-5276
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Carpal tunnel syndrome (CTS) occurs as a result of compression of the median nerve at the wrist. The Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire is a selfadministered region-specific outcome instrument which measures symptom severity and functional status. OBJECTIVES: The aim of this study was to evaluate the clinical and electrophysiological relationship with QDASH scale in CTS. MATERIAL AND METHODS: The study included 99 females and 22 males in total out of 121 idiopathic CTS patients with the mean age of 47.9 ±9.5 years. Patients were divided clinically and electrophysiologically into 2 groups as severe and mild based on modified criteria defined by Italian CTS working group. Pain severity was evaluated by visual analog scale (VAS). Patients were evaluated functionally by QDASH scale and the relationship between clinical and electrophysiological effect intensity (degree) was examined. RESULTS: QDASH scores were found significantly high in female patients, in patients with long disease duration (6 years and more), patients with clinically severe symptoms, and the ones with positive phalen test in both hands. Statistically significant positive relationship was found between QDASH scores, disease duration and clinical severity. However, no relationship was found between electrophysiological severity and QDASH. A mild and positive correlation was observed among disease duration, clinical severity and VAS. A small and positive correlation was detected between VAS and QDASH. CONCLUSIONS: Although electrophysiological findings were prioritized in the follow-up and treatment strategies of CTS patients, clinical and patient-oriented assessment scales should be dealt together. Despite the electrophysiological findings, we believe that individual differences are effective in clinical and functional capacity. We conclude that since QDASH scale has a simple applicability in a short time, it can be used for assessing the symptom severity and disability of patients with CTS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.17219/acem/67947

  6 / 20939 MEDLINE  
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[PMID]: 29280371
[Au] Autor:Szczuko M; Malarczyk I; Zapalowska-Chwyc M
[Ad] Address:Pomeranian Medical University in Szczecin, Faculty of Health Sciences, Department of Biochemistry and Human Nutrition, Broniewskiego 24, 71-460 Szczecin, Poland
[Ti] Title:Improvement in anthropometric parameters after rational dietary intervention in women with Polycystic Ovary Syndrom as the best method to support treatment
[So] Source:Rocz Panstw Zakl Hig;68(4):409-417, 2017.
[Is] ISSN:0035-7715
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Background: Polycystic ovary syndrome (PCOS) is a disorder often occurring in women at reproductive age. An important factor in PCOS pathogenesis is insulin resistance, which pronounces hyperandrogenism and leads to the development of various metabolic disorders Objectives: The aim of this study is to determine the effect of reduction diet with low glycemic index (GI) on anthropometric parameters of women with PCOS and the assessment of the effectiveness of the diet on body mass and adipose tissue reduction Material and methods: The study was performed on 24 women with PCOS diagnosed with Rotterdam's criteria. Anthropometric measurements and bioelectrical impedance were performed. All participants received 7-day diet and recommendations relating to the change in lifestyle. After three months of using the dietary recommendations the measurements were repeated Results: Statistical significance was observed for body mass (↓on average by 5.93 kg±2.95), BMI (↓2.14 kg/m2±1.2), circumference of: waist (↓7.7 cm±5.9), hip (↓4.8 cm±5.4), arm (↓1.9 cm±3.7) and measurements of skin fold under the shoulder blade (↓4.8 mm±4,6), above iliac crest (↓6.76 mm±5.7) and above triceps brachii muscle (↓5.25 mm±7.4). Considering body composition measurements, statistically significant were differences in the measurements of BCMI (↑18.042±8.8), TBW expressed in percentage (↑2.729±2.75) and in litres (↑0.071±5.15), FM in percentage (↓3.291±5.6) and in kg (3.354 kg±4.9) Conclusions: Body mass reduction using a rational diet with low GI is an effective method to support of PCOS treatment. Using reduction diet for three months together with increased physical activity enables to reduce body weight by on average 5.93 kg, which increases the chances to treat infertility in women. This should be the suggested type of diet in PCOS treatment
[Mh] MeSH terms primary: Diet, Reducing/methods
Feeding Behavior
Glycemic Index
Obesity/prevention & control
Polycystic Ovary Syndrome/diet therapy
[Mh] MeSH terms secundary: Adult
Anthropometry
Body Mass Index
Female
Humans
Insulin Resistance
Obesity/etiology
Polycystic Ovary Syndrome/complications
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171228
[St] Status:MEDLINE

  7 / 20939 MEDLINE  
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[PMID]: 29203758
[Au] Autor:Stefanski M; Brulinski K; Stefanska M
[Ad] Address:Oddzial Chirurgii Klatki Piersiowej, Centrum Pulmonologii I Torakochirurgii, Bystra, Polska.
[Ti] Title:[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (dipnech) - an overview of the cases diagnosed at the department of thoracic surgery in the years 2010-2014].
[So] Source:Wiad Lek;70(5):1005-1012, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:pol
[Ab] Abstract:INTRODUCTION: Pulmonary neuroendocrine cells (PNEC) are present in the normal lungs with the incidence of 1 in 2500 epithelial cells. They usually proliferate in the presence of reactive processes related to inflammation and fibrosis of the lung parenchyma. The division of pulmonary neuroendocrine cell hyperplasia proposed by Travis et al. additionally distinguished diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) or proliferation that occurs in people without reactive hyperplasia risk factors. The confirmation of the DIPNECH diagnosis requires staining of biopsy specimens using the immunohistochemical technique for neuroendocrine markers. AIM: The aim of this study is to overview the cases of 5 patients in whom the histopathological DIPNECH diagnosis was made in the process of invasive diagnostics performed at the Department of Thoracic Surgery. The aim of the study is to evaluate typical clinical, functional, radiological and histopathological features of this rare disease syndrome. MATERIAL AND METHODS: In the period from April 2010 to June 2014, five patients with lesions in the lungs were subjected to invasive diagnostics. Histopathological and immunohistochemical examinations of the collected specimens were used to make the DIPNECH diagnosis in these patients. The natural history of the disease was traced based on a 5-year follow-up in one of the patients. In addition, we analyzed the literature with regard to the described cases. CONCLUSIONS: Thanks to the early diagnosis of non-specific lesions in the lungs, typical carcinoid which develops on the basis of discussed DIPNECH, was found in the resected material in two out of five operated patients. The accurate diagnosis of DIPNECH allows for the implementation of appropriate treatment and channels further management of the patient into the right direction.
[Mh] MeSH terms primary: Hyperplasia/diagnostic imaging
Hyperplasia/pathology
Lung Diseases/diagnostic imaging
Lung Diseases/pathology
Neuroendocrine Cells/pathology
[Mh] MeSH terms secundary: Aged
Cell Proliferation
Female
Humans
Immunohistochemistry
Male
Middle Aged
Respiratory Function Tests
Tomography, X-Ray Computed
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE

  8 / 20939 MEDLINE  
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[PMID]: 29203757
[Au] Autor:Osovska NY; Datsyuk OI; Kuzminova NV; Shaprynskyi YV; Bevz HV; Pashynskyy YM; Bondarchuk OD; Sergiichuk OV; Karyi YV; Mazur GM
[Ad] Address:National Pirogov Memorial Medical University, Vinnytsya, Ukraine.
[Ti] Title:Variant of myocardial infarction course in the patient with left ventricular non-compaction.
[So] Source:Wiad Lek;70(5):998-1004, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Non-compacted left ventricle in adults is a rare occurrence, though it is diagnosed even more rarely. As a rule in patients with non-compacted left ventricle (LVNC) other pathologic condition is diagnosed, notably hypertrophic or dilated cardiomyopathy. The majority of LVNC cases are diagnosed in early infancy but currently there are asymptomatic cases detected by means of echocardiographic examination. Real prevalence of LVNC is unknown. According to many authors LVNC occurs in 9.2-9.5% of children with diagnosed cardiomyopathies. The majority of such children do not survive till adulthood because of progressive severe heart failure, fatal arrhythmias and thromboembolisms. This value ranges from 0.014 to 0.05% in adult population. The article presents a clinical case illustrating the stages in establishing the diagnosis of non-compacted left ventricle in a young patient with myocardial infarction and congestive heart failure. Common characteristics of non-compacted left ventricle and connective tissue dysplasia syndrome in the patient suggested etiopathogenetic relationship between these two pathologic states. The basic common characteristic feature of both non-compacted left ventricle and connective tissue dysplasia syndrome proved to be multiple abnormal chords of the left ventricle. The patient was supposed to have some coronary circulation abnormality inherited together with non-compacted left ventricle and connective tissue dysplasia syndrome. Adverse prognosis and high mortality in non-compacted left ventricle require its early recognition and differentiated approach to treatment depending on the severity of the disease and using all modern methods of treatment both conservative and surgical.
[Mh] MeSH terms primary: Isolated Noncompaction of the Ventricular Myocardium/diagnostic imaging
Isolated Noncompaction of the Ventricular Myocardium/physiopathology
[Mh] MeSH terms secundary: Adult
Cardiomyopathy, Dilated/pathology
Child
Echocardiography
Heart Ventricles/pathology
Humans
Medical History Taking
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE

  9 / 20939 MEDLINE  
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[PMID]: 29203755
[Au] Autor:Zhdan VМ; Kitura YМ; Kitura OY; Babanina MY; Tkachenko MV; Lebid VG
[Ad] Address:Higher State Educational Establishment Of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
[Ti] Title:Churg-strauss syndrome: a case report.
[So] Source:Wiad Lek;70(5):992-994, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:A clinical case of Churg-Strauss syndrome has been reported on the 53-year-old female patient Ts. with bronchial asthma and allergic rhinitis. The main clinical signs and syndromes depending on the stage of the disease are presented, as well as therapeutic treatment of patients with this disease.
[Mh] MeSH terms primary: Churg-Strauss Syndrome/diagnosis
Churg-Strauss Syndrome/therapy
[Mh] MeSH terms secundary: Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE

  10 / 20939 MEDLINE  
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[PMID]: 29203753
[Au] Autor:Starostka-Tatar A; Labuz-Roszak B; Skrzypek M; Gasior M; Gierlotka M
[Ad] Address:Katedra I Klinika Neurologii W Zabrzu, Slaski Uniwersytet Medyczny W Katowicach, Zabrze, Polska.
[Ti] Title:[Definition and treatment of stroke over the centuries].
[So] Source:Wiad Lek;70(5):982-987, 2017.
[Is] ISSN:0043-5147
[Cp] Country of publication:Poland
[La] Language:pol
[Ab] Abstract:Stroke was already diagnosed in the ancient times. For hundreds of years the treatment of this disease has changed radically. According to the current WHO definition, stroke is a clinical syndrome caused by focal or generalized brain injury that lasts more than 24 hours or leads to death and has no other cause than vascular. Stroke constitutes a big social and economic problem, as it can lead to death or disability. In the highly developed countries stroke is the third most common cause of adult deaths, the second leading cause of dementia, and the most common cause of disability. The consequences of stroke also include epilepsy and depression. In the twentieth century, stroke was only treated symptomatically and rehabilitation was limited to passive exercises. The first breakthrough in ischemic stroke therapy was the introduction of aspirin (ASA), followed by intravenous thrombolysis using recombinant tissue plasminogen activator (rtPA), initially available in our country only in the drug programs, and since 2009 it has been reimbursed by the National Health Fund (NFZ). Gradually invasive stroke treatment has been developed. Mechanical thrombectomy is currently only performed in selected centers, giving hope for more effective stroke treatment. The purpose of this work was to show how stroke treatment has changed over the centuries.
[Mh] MeSH terms primary: Brain Ischemia/therapy
Stroke Rehabilitation
Stroke/therapy
[Mh] MeSH terms secundary: Combined Modality Therapy
Fibrinolytic Agents/therapeutic use
Humans
Thrombectomy/methods
Thrombolytic Therapy/methods
Tissue Plasminogen Activator/therapeutic use
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Fibrinolytic Agents); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171206
[St] Status:MEDLINE


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