Database : MEDLINE
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[PMID]: 29428511
[Au] Autor:Jiao J; Jia X; Liu P; Zhang Q; Liu F; Ma C; Xi P; Liang Z
[Ad] Address:College of Life Science, Northwest of A&F University, Yangling, 712100 Shaanxi, China.
[Ti] Title:Species identification of polygonati rhizoma in China by both morphological and molecular marker methods.
[So] Source:C R Biol;341(2):102-110, 2018 Feb.
[Is] ISSN:1768-3238
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Morphological markers as well as two types of molecular markers, inter-sample sequence repeat (ISSR) and start codon targeted (SCoT) are suitable for species identification of the polygonati rhizoma germplasms. In this paper, we adopted these methods for the identification of rhizomes collected from 47 areas in China. Based on their morphological characters, the collected germplasms were classified into two populations, one with alternate leaf arrangement and the other with verticillate leaf arrangement, and they were comprised of five species and fourteen subgroups. Of the five species identified: Polygonatum kingianum, P. cirrhifolium, P. alternicirrhosum, and P. sibiricum belonged to one cluster, and P. cyrtonema belonged to a different cluster. According to the analysis of both ISSR and SCoT markers, all germplasms with greater genetic similarity were classified into one group. Especially, P. sibiricum and P. cirrhifolium, which shared ∼80% similarity, were clustered together, whereas the germplasms identified as P. kingianum with ∼86% similarity formed a separate clade. P. kingianum showed a much greater genetic similarity with P. cyrtonema than with P. sibiricum. The multidimensional scaling analysis further verified the accuracy and reliability of the molecular marker-based results. Thus, both morphological and molecular methods should be combined for the differentiation of germplasms such as those of polygonati rhizoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process

  2 / 198 MEDLINE  
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[PMID]: 29457519
[Au] Autor:Wang W; Dabu X; He J; Yang H; Yang S; Chen J; Fan W; Zhang G; Cai J; Ai H; Hai M
[Ad] Address:a Yunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China , Kunming , China.
[Ti] Title:Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.
[So] Source:Nat Prod Res;:1-7, 2018 Feb 19.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2-15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC values to comparable those of cisplatin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1434645

  3 / 198 MEDLINE  
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[PMID]: 29451015
[Au] Autor:Zhao H; Wang QL; Hou SB; Chen G
[Ad] Address:a College of Life Science and Technology , Beijing University of Chemical Technology , Beijing , China.
[Ti] Title:Chemical constituents from the rhizomes of Polygonatum sibiricum Red. and anti-inflammatory activity in RAW264.7 macrophage cells.
[So] Source:Nat Prod Res;:1-4, 2018 Feb 16.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Chemical investigation of the rhizomes of Polygonatum sibiricum Red. led to the identification of 27 constituents. Among them, a total of 16 compounds were obtained from Polygonatum for the first time, in which, 3 and 4 were also firstly isolated as natural products. Anti-inflammatory activity studies on 13 isolated compounds showed that ß-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-α, IL-6 and IL-1ß in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells. Moreover, western blotting analysis demonstrated that compound 1 significantly inhibited the expression of COX-2, iNOS and the activation of NF-κB, suggesting that ß-carboline structures may play an important role in inhibition of NF-κB signaling pathway, which thereby inhibits the production of inflammatory factors. The present research may not only help further elucidation of the anti-inflammatory mechanism of P. sibiricum Red., but also provide the potential bioactive molecules for inflammatory diseases research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1440220

  4 / 198 MEDLINE  
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[PMID]: 29343453
[Au] Autor:Long T; Liu Z; Shang J; Zhou X; Yu S; Tian H; Bao Y
[Ad] Address:Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
[Ti] Title:Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways.
[So] Source:Int J Biol Macromol;111:813-821, 2018 Jan 16.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate the anti-cancer effect of Polygonatum sibiricum polysaccharides (PSP) and the underlying mechanism. METHODS: Tumor-bearing mice were randomly divided into normal saline (NS) group, adriamycin (ADM) group, PSP group and lipopolysaccharide (LPS) group. RAW264.7 cells were pre-treated with or without TLR4 inhibitor or MyD88 inhibitor. Quantitative RT-PCR and Western blot were performed to detect the mRNA and protein expressions, respectively. ELISA and Griess reaction was used to measure cytokines and NO levels. Flow cytometry was employed to examine T-lymphocyte subset and CCK-8 assay was used for cell viability. RESULTS: The in vivo experiment found that PSP inhibited tumor growth and improved the spleen index, thymus index, the cytokines secretion and CD4 /CD8 lymphocytes ratio. Compared with the NS group, the mRNA and protein expressions of the critical nodes inTLR4-MAPK/NF-κB signaling pathways (except TRAM) significantly increased in PSP group, as well as the NO and cytokines levels. Nevertheless, PSP had no obvious effects on TRAM. Further analysis showed that PSP effects on the critical nodes in TLR4-MAPK/NF-κB signaling pathways were suppressed by inhibitor in vitro. CONCLUSION: The immunoenhancement effect of PSP against lung cancer is mediated by TLR4-MAPK/NF-κB signaling pathways.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher

  5 / 198 MEDLINE  
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[PMID]: 29262679
[Au] Autor:Liu Q; Li W; Nagata K; Fu H; Okada S; Tanabe I; Kobori Y; Higai K; Norie W; Sasaki T; Asada Y; Zhao H; Bai H; Koike K
[Ad] Address:Faculty of Pharmaceutical Sciences, Toho University , Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
[Ti] Title:Isolation, Structural Elucidation, and Liquid Chromatography-Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum.
[So] Source:J Agric Food Chem;66(2):521-531, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC of 3.2 µM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.
[Mh] MeSH terms primary: Glycosides/chemistry
Glycosides/isolation & purification
Plant Extracts/chemistry
Plant Extracts/isolation & purification
Polygonatum/chemistry
Steroids/chemistry
Steroids/isolation & purification
[Mh] MeSH terms secundary: Cell Proliferation/drug effects
Cell Survival/drug effects
Chromatography, Liquid
Glycosides/pharmacology
Hep G2 Cells
Humans
Mass Spectrometry
Molecular Structure
Plant Extracts/pharmacology
Rhizome/chemistry
Steroids/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Glycosides); 0 (Plant Extracts); 0 (Steroids)
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04488

  6 / 198 MEDLINE  
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[PMID]: 29382227
[Au] Autor:Gvazava L; Nebieridze V; Ganzera M; Skhirtladze A
[Ad] Address:a Department of Phytochemistry , Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University , Tbilisi , Georgia.
[Ti] Title:New furostanol glycosides from Polygonatum multiflorum (L.) All.
[So] Source:Nat Prod Res;:1-8, 2018 Jan 31.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The phytochemical investigation of the whole plant of Polygonatum multiflorum resulted in the isolation of two new steroidal glycosides, polmultoside A (4) and polmultoside B (5), along with three known glycosides protobioside (1), protodeltonin (2) and huangjiangsu A (3). The structures of the isolated compounds have been elucidated by extensive 1D ( H, C) and 2D (COSY, HSQC, HMBC) NMR spectral data analysis, as well as high-resolution mass determinations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1431628

  7 / 198 MEDLINE  
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[PMID]: 29246502
[Au] Autor:Zhao P; Zhao C; Li X; Gao Q; Huang L; Xiao P; Gao W
[Ad] Address:Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address: zhaoping@tju.edu.cn.
[Ti] Title:The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology.
[So] Source:J Ethnopharmacol;214:274-291, 2018 Mar 25.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: The genus Polygonatum (Asparagaceae) comprises 71 species distributed throughout the temperate Northern Hemisphere. The medicinal plants of Polygonatum have been traditionally used as tonics in China, India, Pakistan, Iran and Japan, and have been demonstrated to be highly effective in clinical practice for treating age-related diseases, diabetes, lung diseases, fatigue, feebleness and indigestion. AIM OF THE REVIEW: This paper aims to provide the links among traditional uses, chemical constituents, pharmacological effects and toxicity to support their therapeutic potential and uncover opportunities for future research. MATERIALS AND METHODS: The relevant information on the genus Polygonatum was gathered from scientific databases (Google Scholar, Web of Science, SciFinder, ScienceDirect, ACS Publications, PubMed, Wiley Online Library, CNKI). Information was also obtained from online databases, books, Ph.D. dissertations and M.Sc. theses. The literature cited in this review dates from 1917 to June 2017. RESULTS: At least 37 species and 1 variety of Polygonatum plants have been used as traditional medicine and functional food. The major chemical constituents of Polygonatum plants are steroidal saponins, triterpenoid saponins, homoisoflavanones, polysaccharides and lectins. A putative biosynthetic pathway of steroidal saponins and triterpenoid saponins has been established based on the compounds isolated from Polygonatum plants. The crude extracts and certain pure compounds from Polygonatum plants have shown a wide range of pharmacological effects such as anti-aging, anti-diabetic, anti-fatigue, and anticancer effects. The rhizomes of Polygonatum plants have a low degree of toxicity after processing. CONCLUSIONS: Based on this review, some traditional uses of Polygonatum species have been confirmed by pharmacological studies, such as its anti-osteoporosis, neuroprotective, immunomodulatory, anti-diabetic and anti-fatigue effects. Most of the pharmacological effects of this genus can be attributed to its polysaccharides, saponins and lectins. However, to clarify the chemical differences that lead to the different traditional uses between "Huangjing" (derived from P. sibiricum, P. kingianum, P. cyrtonema) and "Yuzhu" (derived from P. odoratum), a systematic comparison of the small molecule compositions and polysaccharides of these four species is needed. In addition to these four species, other locally used medicinal Polygonatum species should be the subject of research, and the chemical and pharmacological relationships of these species should be investigated to expand the medicinal resources and standardize the use of Polygonatum species.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[St] Status:In-Process

  8 / 198 MEDLINE  
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[PMID]: 29228787
[Au] Autor:Kumar N; Chaiyasut C
[Ad] Address:1 School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand.
[Ti] Title:Health Promotion Potential of Vegetables Cultivated in Northern Thailand: A Preliminary Screening of Tannin and Flavonoid Contents, 5α-Reductase Inhibition, Astringent Activity, and Antioxidant Activities.
[So] Source:J Evid Based Complementary Altern Med;22(4):573-579, 2017 Oct.
[Is] ISSN:2156-5899
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Many of scientific evidences suggest that regular consumption of fruits and vegetables can prevent chronic diseases. In Northern Thailand, there are many vegetables that are usually consumed by local people. In this study, 17 local vegetables were selected and extracted with 95% ethanol. The extracts were screened for 5α-reductase inhibitory activity, total tannin and flavonoid contents, astringent and antioxidant activities. The results showed that Spondias pinnata and Ocimum americanum had the highest tannin and flavonoid content, respectively. Neptunia oleracea was the most potent 5α-reductase inhibitor. For antioxidant activities, S pinnata was the most potent ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenger and the most potent ferric reducer. Polygonatum odoratum was the most potent hydrogen peroxide scavenger and Leucaena leucocephala was the most potent DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenger among the tested samples. This suggests that local vegetables in Northern Thailand have a health promotion potential, which can be further developed as nutritional supplements, preventive medicines, and topical products for cosmetic purposes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:In-Data-Review
[do] DOI:10.1177/2156587216686689

  9 / 198 MEDLINE  
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[PMID]: 29168389
[Au] Autor:Zhang HY; Hu WC; Ma GX; Zhu NL; Sun XB; Wu HF; Xu XD
[Ad] Address:a Center of Research and Development on Life Sciences and Environment Sciences , Harbin University of Commerce , Harbin 150076 , China.
[Ti] Title:A new steroidal saponin from Polygonatum sibiricum.
[So] Source:J Asian Nat Prod Res;:1-7, 2017 Nov 23.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3-5 showed significant cytotoxicity against HepG2 cell lines with IC values of 14.2, 12.1 and 8.5 µM, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171123
[Lr] Last revision date:171123
[St] Status:Publisher
[do] DOI:10.1080/10286020.2017.1351436

  10 / 198 MEDLINE  
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[PMID]: 29133094
[Au] Autor:Li L; Liao BY; Thakur K; Zhang JG; Wei ZJ
[Ad] Address:School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, PR China; School of life Science, Hefei Normal University, Hefei 230006, PR China. Electronic address: 583003456@qq.com.
[Ti] Title:The rheological behavior of polysaccharides sequential extracted from Polygonatum cyrtonema Hua.
[So] Source:Int J Biol Macromol;, 2017 Nov 11.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The present study investigated the rheological properties of polysaccharides (HBSS, CHSS, DASS, CASS) sequentially extracted from Polygonatum cyrtonema Hua. The monosaccharide, uronic acid, total carbohydrate, protein content of four polysaccharides were analyzed. The total carbohydrate content of PCHPs (HBSS, CHSS, DASS, and CASS) were 78.39, 71.86, 69.99 and 73.73% respectively, containing Rha, Ara, Man, Gal besides uronic acid and protein. The non-Newtonian fluidic nature of PCHPs was affected by the types of polysaccharides, concentration, temperature, pH, types and concentration of salt ions. Specifically, the apparent viscosity of four PCHPs solutions at 1%(w/w) concentration were shown as CHSS>HBSS>CHSS>CASS with increased concentration and shear thinning phenomenon and decreased system temperature. Subsequently, the apparent viscosity of four PCHPs at pH 10 or pH 4 were lower than that at pH 7. The Na increased the apparent viscosity of HBSS at increasing concentrations, while, decreased for remaining fractions with increasing Na concentration. Moreover, higher Ca concentration was inversely proportional to apparent viscosity of four PCHPs. The oscillatory rheological properties showed that linear viscoelastic region of PCHPs was 1-4% which resulted into viscoelastic material. HBSS, DASS and CASS at 0.1%(w/w) showed more viscous behavior at low frequency and enhanced elastic property with the increasing oscillation frequency.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:Publisher


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