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[PMID]: 29436004
[Au] Autor:Miura K; Akashi T; Ando N; Ayabe S; Kayamori K; Namiki T; Eishi Y
[Ad] Address:Division of Surgical Pathology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
[Ti] Title:Homeobox transcriptional factor engrailed homeobox 1 is specifically expressed in normal and neoplastic sweat gland cells.
[So] Source:Histopathology;, 2018 Feb 12.
[Is] ISSN:1365-2559
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin. Among those 37 genes, the engrailed homeobox 1 (En1) was expressed in normal eccrine glands but not in the epidermal keratinocytes. Expression of En1 was found throughout the eccrine glands, but not in the apocrine secretory coils, sebaceous glands, or hair follicles. Expression of En1 was immunohistochemically examined in 111 cases of cutaneous epithelial neoplasms. All the 9 cases of poroma, 7 cases of spiradenoma, and 6 cases of syringoma, which are considered to differentiate toward eccrine glands, showed positive nuclear staining in most of the tumour cells. Sebaceous gland and hair follicle tumours were immuno-negative. En1 was focally expressed in the epidermal neoplasms of seborrheic keratosis and squamous cell carcinoma. CONCLUSION: En1 was specifically expressed in normal eccrine glands and was expressed in most of the tumour cells of sweat gland neoplasms with eccrine gland differentiation. En1 was focally expressed in epidermal neoplasms, however, it was absent in sebaceous or hair follicle neoplasms. These findings will help in the histopathological diagnosis as well as to understand the histogenesis of sweat gland neoplasms. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1111/his.13486

  2 / 489 MEDLINE  
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[PMID]: 29194789
[Au] Autor:Marchetti MA; Marino ML; Virmani P; Dusza SW; Marghoob AA; Nazzaro G; Lallas A; Landi C; Cabo H; Quiñones R; Gomez E; Puig S; Carrera C
[Ad] Address:Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[Ti] Title:Dermoscopic features and patterns of poromas: a multicentre observational case-control study conducted by the International Dermoscopy Society.
[So] Source:J Eur Acad Dermatol Venereol;, 2017 Dec 01.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized. OBJECTIVE: To determine the clinical-dermoscopic features of poromas. METHODS: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image. RESULTS: Poromas were most commonly non-pigmented (85.8%), papules (35.4%) and located on non-acral sites (65.5%). In multivariate analysis, dermoscopic features associated with poroma included white interlacing areas around vessels (OR: 7.9, 95% CI: 1.9-32.5, P = 0.004), yellow structureless areas (OR: 2.5, 95% CI: 1.1-6.0, P = 0.04), milky-red globules (OR: 3.9, 95% CI: 1.4-11.1, P = 0.01) and poorly visualized vessels (OR: 33.3, 95% CI: 1.9-586.5, P = 0.02). The presence of branched vessels with rounded endings was positively associated with poromas but did not reach statistical significance (OR: 2.4, 95% CI: 0.8-6.5, P = 0.10). The presence of any of these five features was associated with a sensitivity and specificity of 62.8% and 82.0%, respectively. CONCLUSION: We identified dermoscopic features that are specific to the diagnosis of poroma. Overall, however, the prevalence of these features was low. Significant clinical and dermoscopic variability is a hallmark of these uncommon tumours, which are most prevalent on non-acral sites.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180124
[Lr] Last revision date:180124
[St] Status:Publisher
[do] DOI:10.1111/jdv.14729

  3 / 489 MEDLINE  
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[PMID]: 29293126
[Au] Autor:Alegría-Landa V; Kutzner H; Requena L
[Ad] Address:Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
[Ti] Title:Cuticular Poroma: A Poroma Mostly Composed of Cuticular Cells (Cuticuloma).
[So] Source:Am J Dermatopathol;, 2017 Dec 28.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Poromas are benign cutaneous adnexal neoplasms with differentiation toward excretory ducts of eccrine and apocrine glands. They are mainly composed of solid aggregates of small, monomorphous, round, and basophilic poroid cells, with a lower proportion of larger, squamous, eosinophilic cuticular cells, which are lining ductal structures with an eosinophilic luminal cuticle. In most cases of poromas, cuticular cells represent a small proportion of the neoplastic aggregates. We report 2 poromas mostly composed of cuticular cells, and on the basis of these findings, we have named cuticuloma to this histopathologic variant of poroma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180102
[Lr] Last revision date:180102
[St] Status:Publisher
[do] DOI:10.1097/DAD.0000000000001086

  4 / 489 MEDLINE  
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[PMID]: 29293123
[Au] Autor:Karpathiou G; Mobarki M; Corsini T; Douchet C; Chauleur C; Peocʼh M
[Ad] Address:Departments of Pathology, and.
[Ti] Title:Eccrine Poroma of the Vulva.
[So] Source:Am J Dermatopathol;, 2017 Dec 28.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180102
[Lr] Last revision date:180102
[St] Status:Publisher
[do] DOI:10.1097/DAD.0000000000001059

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[PMID]: 29245095
[Au] Autor:Ramasenderan N; Shahir H; Omar SZ
[Ad] Address:Department of Plastic and Reconstructive Surgery, Sultanah Nur Zahirah Hospital, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia. Electronic address: r.nandinii25@gmail.com.
[Ti] Title:A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report.
[So] Source:Int J Surg Case Rep;42:116-120, 2017 Dec 08.
[Is] ISSN:2210-2612
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland. CASE PRESENTATION: We presented a 65-year-old, Asian, female with medical co-morbids, who came with both a facial squamous cell carcinoma and a long-standing lesion over her left forearm. Histopathological finding of the left forearm demonstrated eccrine porocarcinoma. CONCLUSION: Mohs micrographic surgery is the mainstay treatment of cutaneous carcinoma. It is important to rule out associated syndromes in patient who present with multiple cutaneous appendageal tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171224
[Lr] Last revision date:171224
[St] Status:Publisher

  6 / 489 MEDLINE  
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[PMID]: 29269125
[Au] Autor:Bosic M; Kirchner M; Brasanac D; Leichsenring J; Lier A; Volckmar AL; Oliveira C; Buchhalter I; Stögbauer F; Zivkovic-Perisic S; Goeppert B; Schirmacher P; Penzel R; Endris V; Stenzinger A
[Ad] Address:Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
[Ti] Title:Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.
[So] Source:Pathology;, 2017 Dec 18.
[Is] ISSN:1465-3931
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The genetic landscape of rare benign tumours and their malignant counterparts is still largely unexplored. While recent work showed that mutant HRAS is present in subsets of poromas and porocarcinomas, a more comprehensive genetic view on these rare adnexal neoplasms is lacking. Using high-coverage next generation sequencing, we investigated the mutational profile of 50 cancer-related genes in 12 cases (six poromas and six porocarcinomas). Non-synonymous mutations were found in two-thirds of both poromas and porocarcinomas. Hotspot HRAS mutations were identified in two poromas (p.G13R and p.Q61R) and one porocarcinoma (p.G13C). While in poromas only few cases showed single mutated genes, porocarcinomas showed greater genetic heterogeneity with up to six mutated genes per case. Recurrent TP53 mutations were found in all porocarcinomas that harboured mutated genes. Non-recurrent mutations in porocarcinomas were found in several additional tumour suppressors (RB1, APC, CDKN2A, and PTEN), and genes implicated in PI3K-AKT and MAPK signalling pathways (ABL1, PDGFRA, PIK3CA, HRAS, and RET). UV-associated mutations were found in TP53, APC, CDKN2A, PTEN, and RET. In conclusion, our study confirms and extends the spectrum of genetic lesions in poromas and porocarcinomas. While poromas exhibited only few mutations, which did not involve TP53, the majority of porocarcinomas harboured UV-mediated mutations in TP53 with some of these cases showing considerable genetic heterogeneity that may be clinically exploitable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[St] Status:Publisher

  7 / 489 MEDLINE  
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[PMID]: 29252016
[Au] Autor:Göktay F; Günes P; Akpolat ND; Ferhatoglu ZA; Önenerk M
[Ti] Title:Periungual Eccrine Poroma Masquerading as Ingrown Toenails .
[So] Source:J Am Podiatr Med Assoc;107(6):551-555, 2017 Nov.
[Is] ISSN:1930-8264
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eccrine poroma is a rare benign adnexal neoplasm originating from a portion of the intraepidermal eccrine sweat gland duct and the acrosyringium. Typically, the lesions are asymptomatic, slow-growing nodules, which may be found in any sweat gland-bearing area. Multiple red lacunae, glomerular vessels, hairpin vessels, flower- and leaf-like vascular patterns, a polymorphic vascular pattern, globule/lacunae-like structures, a frog egg-like appearance, and comedo-like openings have been defined as characteristic dermoscopic patterns of the disease. We report a case of eccrine poroma in an unusual periungual and subungual location mimicking ingrown toenails. The dermoscopic findings of the lesions were compatible with those of eccrine poromas located in areas other than the periungual area. Recurrence was observed after the first excisional biopsy. There was no recurrence 10 months after the second surgical intervention, and near-complete regrowth of the nail plate was achieved. Eccrine poroma should be considered as a differential diagnosis in the presence of slow-growing, erythematous, painful, hemorrhagic papular lesions located in the periungual area in conjunction with a prediagnosis of ingrown toenails and malignant processes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171218
[Lr] Last revision date:171218
[St] Status:In-Process
[do] DOI:10.7547/16-127

  8 / 489 MEDLINE  
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[PMID]: 29139150
[Au] Autor:Ichiyama S; Hoashi T; Funasaka Y; Mikami E; Akiyama M; Esaki E; Kubo M; Ansai SI; Tanaka M; Saeki H
[Ad] Address:Department of Dermatology, Nippon Medical School, Tokyo, Japan.
[Ti] Title:Pigmented poroma on the temporal region dermoscopically mimicking basal cell carcinoma: A report of two cases.
[So] Source:J Dermatol;, 2017 Nov 15.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1711
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:Publisher
[do] DOI:10.1111/1346-8138.14129

  9 / 489 MEDLINE  
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[PMID]: 29095742
[Au] Autor:Horenstein MG; Sandoval MP; Lo Y; Jacob J
[Ad] Address:*Department of Pathology, The Dermatology Group, West Orange, NJ; and †Department of Pathology, Montefiore Medical Center, Bronx, NY.
[Ti] Title:Holocrine Poroma: A Distinctive Adnexal Tumor.
[So] Source:Am J Dermatopathol;, 2017 Nov 01.
[Is] ISSN:1533-0311
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89.6%), infundibular follicular structures (66.7%), and entrapped sebocytes (56.3%). No definite apocrine decapitation secretions in FSPT were found. Immunohistochemistry was strongly positive for CK903 and focally positive for CAM5.2, epithelial membrane antigen, and carcinoembryonic antigen. No loss of MLH-1, MSH-2, or MSH-6 mismatch repair proteins was found. FSPT had distinctive features that differentiate them from eccrine poromas including the frequent head and neck locations (62.5% vs. 20.6%, P < 0.01), squamous cytology (100% vs. 1.6%, P < 0.01), more prominent cytoplasmic vacuolization (score 1.4/4.0 vs. 0.3/4.0, P < 0.01), presence of infundibular follicular structures (score 1.2/4.0 vs. 0.03/4.0, P < 0.01), presence of ducts with steatocystoma-like cuticles (89.6% vs. 0.0%, P < 0.01), and less stromal hyalinization (score 1.0/4.0 vs. 2.5/4.0, P < 0.01). The authors propose that FSPT are distinctive benign tumors originating from the sebaceous gland duct and are therefore best categorized as holocrine poroma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:Publisher
[do] DOI:10.1097/DAD.0000000000001046

  10 / 489 MEDLINE  
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[PMID]: 29085717
[Au] Autor:Ribeiro F; Leocadia E; Macarenco RS; Lapins J; Huet P; Akay BN; Steiner D
[Ad] Address:Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
[Ti] Title:Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
[So] Source:Dermatol Pract Concept;7(3):35-37, 2017 Jul.
[Is] ISSN:2160-9381
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. We report the first case of RASD mimicking both clinically and dermoscopically a melanoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5826/dpc.0703a07


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