Database : MEDLINE
Search on : Pulpitis [Words]
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[PMID]: 29509518
[Au] Autor:Milani AS; Froughreyhani M; Rahimi S; Zand V; Jafarabadi MA
[Ad] Address:Assistant Professor, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
[Ti] Title:Volume of Anesthetic Agents and IANB Success: A Systematic Review.
[So] Source:Anesth Prog;65(1):16-23, 2018.
[Is] ISSN:1878-7177
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The aim of this study was to provide an evidence-based answer to the question: "Is 3.6-mL volume of an anesthetic agent more effective than 1.8-mL volume in providing anesthesia for mandibular molars?" Following formulation of research question and keyword selection, a comprehensive search of the following databases was conducted: Cochrane library, PubMed, Scopus, Google Scholar, ProQuest, and Clinicaltrials.gov. Three-phase eligibility appraisal and quality assessment of the studies were carried out by 2 independent reviewers. To reduce clinical heterogeneity, the included studies were divided into 2 groups: studies on healthy teeth and studies on teeth with pulpitis. The data of included studies were statistically combined through meta-analysis using a fixed-effects model. A total of 20,778 records were initially retrieved from the search. Following screening and eligibility assessment, 8 studies met the eligibility criteria and were included for qualitative synthesis. Of those, 5 studies were qualified for meta-analysis. In the irreversible pulpitis group, increasing the volume of anesthetic agent from 1.8 to 3.6 mL significantly increased the success rate of inferior alveolar nerve block (risk ratio = 2.45, 95% CI: 1.67-3.59, p < .001). However, there was insufficient evidence to draw a conclusion regarding healthy teeth.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review
[do] DOI:10.2344/anpr-65-01-03

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[PMID]: 29260756
[Au] Autor:Bykova NI; Sirak SV; Kobylkina TL; Odolsky AV; Bykov IM; Arutyunov AV
[Ad] Address:Kuban State Medical University, Krasnodar, Russia.
[Ti] Title:Optimizatsiia reparativnogo dentinogeneza pri éksperimental'nom osteoporoze. [Optimization of reparative dentinogenesis in experimental osteoporosis].
[So] Source:Stomatologiia (Mosk);96(6):4-8, 2017.
[Is] ISSN:0039-1735
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The aim of the study was to assess histochemical changes of the dental pulp in direct pulp capping/experimental osteoporosis animal model. The study was performed on 20 two-year sheep with simulated acute pulpitis divided in 2 groups: main (15 animals/120 teeth) and control (5 animals/40 teeth). Direct pulp capping in the main group included tissue-engineered structure composed of a hydrogel PuraMatrix/3DM with ectomesenchymal stem cells immobilized on collagen sponge. In the control group collagen sponges with hydrocortisone furatsilin, chondroitin sulfate, аnaesthesinum were used for the same purpose. Dentinal bridge formation was much slower in controls than in the main group. Developed tissue-engineered design optimizes each stage of the healing process by protecting the pulp from infection, reduction of exudation, hemostatic effect and in long term contributes to a significant acceleration of the formation of the dentinal bridge.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process
[do] DOI:10.17116/stomat20179664-8

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[PMID]: 28449751
[Au] Autor:Brignardello-Petersen R
[Ti] Title:Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis.
[So] Source:J Am Dent Assoc;148(5):e47, 2017 05.
[Is] ISSN:1943-4723
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Ibuprofen
Pulpitis
[Mh] MeSH terms secundary: Analgesics
Anesthesia, Dental
Anesthetics, Local
Double-Blind Method
Humans
Mandibular Nerve
Molar
Nerve Block
[Pt] Publication type:REVIEW; COMMENT
[Nm] Name of substance:0 (Analgesics); 0 (Anesthetics, Local); WK2XYI10QM (Ibuprofen)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:D; IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE

  4 / 2950 MEDLINE  
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[PMID]: 29505090
[Au] Autor:Wu H; He M; Yang R; Zuo Y; Bian Z
[Ad] Address:The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
[Ti] Title:AEG-1 participates in the production of pro-inflammatory cytokines in dental pulp cells via NF-κB signaling pathway.
[So] Source:Int Endod J;, 2018 Mar 05.
[Is] ISSN:1365-2591
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: To identify the role of astrocyte elevated gene-1 (AEG-1) and the mechanism underlying the inflammatory response in dental pulp cells. METHODOLOGY: AEG-1 expression was detected at different stages of pulpitis in a rat model using immunohistochemistry. RT-qPCR and Western blot were used to assess AEG-1 expression in human dental pulp cells stimulated by lipopolysaccharide (LPS). The LPS-induced expression of inflammatory cytokine genes was quantified by RT-qPCR in cells transfected with AEG-1 or negative control (NC) siRNA. Immunofluorescence and Western blot were utilized to evaluate the activation of NF-κB signaling in AEG-1-knockdown cells. AEG-1 expression was also investigated by Western blot in dental pulp cells pre-treated with inhibitors of NF-κB and PI-3K signaling before the addition of LPS. Data were statistically analysed by one-way ANOVA. RESULTS: The exposure of dental pulp tissue to LPS resulted in acute inflammation with necrosis and AEG-1 expression in the pulp tissue beneath the perforation. In LPS-stimulated dental pulp cells, AEG-1 mRNA and protein was significantly up-regulated (P <0 .05) in a time- and dose-dependent manner. In AEG-1-knockdown cells, the synthesis of IL-1, IL-6, and TNF-α mRNA was suppressed significantly (P <0 .05) upon LPS induction. AEG-1 knockdown also inhibited nuclear translocation of p65. Suppression of NF-κB and PI-3K abrogated the LPS-induced up-regulation of AEG-1. CONCLUSION: AEG-1 participated in inflammatory cytokine synthesis via NF-κB signaling in dental pulp. Both NF-κB and PI-3K signaling are involved in LPS-induced AEG-1 expression in dental pulp cells. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1111/iej.12921

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[PMID]: 29499561
[Au] Autor:Bakri MM; Yahya F; Munawar KMM; Kitagawa J; Hossain MZ
[Ad] Address:Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
[Ti] Title:Transient receptor potential vanilloid 4 (TRPV4) expression on the nerve fibers of human dental pulp is upregulated under inflammatory condition.
[So] Source:Arch Oral Biol;89:94-98, 2018 Feb 21.
[Is] ISSN:1879-1506
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Transient receptor potential vanilloid 4 (TRPV4) has been considered as a mechano-, thermo- and osmo-receptor. Under inflammatory conditions in dental pulp, teeth can become sensitive upon exposure to a variety of innocuous stimuli. The objective of the present study was to investigate the expression of the TRPV4 channel on nerve fibers in human dental pulp of non-symptomatic and symptomatic teeth associated with inflammatory conditions. DESIGN: Dental pulp from extracted human permanent teeth was processed for fluorescence immunohistochemistry. Ten asymptomatic (normal) and 10 symptomatic (symptoms associated with pulpitis) teeth were used in this study. Nerve fibers were identified by immunostaining for a marker, protein gene product 9.5, and the cells were counterstained with 4',6-diamidino-2-phenylindole. An anti-TRPV4 antibody was used to trace TRPV4 expression. RESULTS: TRPV4 expression was co-localized with the nerve fiber marker. Immunoreactivity for TRPV4 was more intense (p < 0.05) in the nerves of symptomatic teeth than those of normal teeth. The number of co-localization spots was increased significantly (p < 0.05) in the dental pulp of symptomatic teeth compared with that of asymptomatic (normal) teeth. CONCLUSIONS: There is expression of TRPV4 channels on the nerve fibers of human dental pulp. Our findings suggest upregulation of TRPV4 expression under inflammatory conditions in the pulp. The upregulation of TRPV4 channels may be associated with the exaggerated response of dental pulp to innocuous mechanical, thermal and osmotic stimuli under inflammatory conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher

  6 / 2950 MEDLINE  
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[PMID]: 29483734
[Au] Autor:Zhang MM; Zheng YD; Liang YH
[Ad] Address:Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
[Ti] Title:[A prognostic model for assessment of outcome of root canal treatment in teeth with pulpitis or apical periodontitis].
[So] Source:Beijing Da Xue Xue Bao Yi Xue Ban;50(1):123-130, 2018 Feb 18.
[Is] ISSN:1671-167X
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To present a prognostic model for evaluating the outcome of root canal treatment in teeth with pulpitis or apical periodontitis 2 years after treatment. METHODS: The implementation of this study was based on a retrospective study on the 2-year outcome of root canal treatment. A cohort of 360 teeth, which received treatment and review, were chosen to build up the total sample size. In the study, 143 teeth with vital pulp and 217 teeth with apical periodontitis were included. About 67% of the samples were selected randomly to derive a training date set for modeling, and the others were used as validating date set for testing. Logistic regression models were used to produce the prognostic models. The dependent variable was defined as absence of periapical lesion or reduction of periapical lesion. The predictability of the models was evaluated by the area under the receiver-operating characteristic (ROC) curve (AUC). RESULTS: Four predictors were included in model one (absence of apical lesion): pre-operative periapical radiolucency, canal curvature, density and apical extent of root fillings. The AUC was 0.802 (95%CI: 0.744-0.859). And the AUC of the testing date was 0.688. Only the density and apical extent of root fillings were included to present model two (reduction of apical lesion). The AUC of training dates and testing dates were 0.734 (95%CI: 0.612-0.856) and 0.681, respectively. As predicted by model one, the probability of absence of periapical lesion 2 years after endodontic treatment was 90% in pulpitis teeth with sever root-canal curvature and adequate root canal fillings, but 51% in teeth with apical periodontitis. When using prognostic model two for prediction, in teeth with apical periodontitis, the probability of detecting lesion reduction with adequate or inadequate root fillings was 95% and 39% 2 years after treatment. CONCLUSION: The pre-operative periapical status, canal curvature and quality of root canal treatment could be used to predict the 2-year outcome of root canal treatment.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process

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[PMID]: 29483293
[Au] Autor:Nishio Ayre W; Melling G; Cuveillier C; Natarajan M; Roberts JL; Marsh LL; Lynch CD; Maillard JY; Denyer SP; Sloan AJ
[Ad] Address:School of Dentistry, Cardiff University, Cardiff, UK. ayrewn@cardiff.ac.uk.
[Ti] Title: demonstrates pathogenicity through increased attachment in an polymicrobial pulpal infection.
[So] Source:Infect Immun;, 2018 Feb 26.
[Is] ISSN:1098-5522
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study investigated the host response to a polymicrobial pulpal infection consisting of and , bacteria commonly implicated in dental abscesses and endodontic failure, using a validated rat tooth model. Tooth slices were inoculated with planktonic cultures of or alone or in co-culture at ratios of 50:50 and 90:10 to Attachment was semi-quantified by measuring area covered by fluorescently labelled bacteria. Host response was established by viable histological cell counts and inflammatory response using RT-qPCR and immunohistochemistry. A significant reduction in cell viability was observed for single and polymicrobial infections, with no significant differences between infection types (≈2000cells/mm for infected pulps compared to ≈4000cells/mm for uninfected pulps). demonstrated significantly higher levels of attachment (6.5%) compared to alone (2.3%) and mixed species infections (3.4% for 50:50 and 2.3% for 90:10), with a remarkable affinity to the pulpal vasculature. Infections with demonstrated the greatest increase in TNF-α (47.1 fold for , 14.6 fold for , 60.1 fold for 50:50 and 25.0 fold for 90:10) and IL-1ß expression (54.8 fold for , 8.8 fold for , 54.5 fold for 50:50 and 39.9 fold for 90:10) when compared to uninfected samples. Immunohistochemistry confirmed this with the majority of inflammation localised to the pulpal vasculature and odontoblast regions. Interestingly, supernatant and heat killed treatment was unable to induce the same inflammatory response, suggesting pathogenicity in pulpitis is linked to its greater ability to attach to the pulpal vasculature.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher

  8 / 2950 MEDLINE  
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[PMID]: 29397003
[Au] Autor:Taha NA; Abdelkhader SZ
[Ad] Address:Department of Conservative Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
[Ti] Title:Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis.
[So] Source:Int Endod J;, 2018 Feb 03.
[Is] ISSN:1365-2591
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: To assess the outcome of full pulpotomy using Biodentine in permanent teeth with carious exposures and symptoms indicative of irreversible pulpitis. METHODOLOGY: Sixty-four permanent molar teeth with symptomatic vital pulps in 52 patients aged 19-69 years were included. Preoperative pulpal and periapical diagnosis was established. After informed consent, the tooth was anaesthetized, isolated using rubber dam and disinfected with 5% NaOCl before caries excavation; subsequently, the pulp was amputated to the level of the canal orifices. Haemostasis was achieved, and a 3-mm layer of Biodentine (Septodont, Saint-Maur-des-Fosses, France) was placed as the pulpotomy agent. Resin-modified glass-ionomer liner was placed and the tooth restored with either resin composite or amalgam, and a postoperative periapical radiograph exposed. Clinical and radiographic evaluation was completed at 6 months and 1 year postoperatively. Pain levels were scored preoperatively and 2 days post-treatment. RESULTS: Clinical signs and symptoms indicative of irreversible pulpitis were established in all teeth, and periapical rarefaction was present in nine teeth. After 2 days, 93.8% reported complete relief of pain. At 6 months, 63 of 64 attended recall with 98.4% clinical and radiographic success. At 1 year, 59 of 63 attended recall, with 100% clinical and 98.4 radiographic success. Seven of eight cases with periapical rarefaction who attended recall had improvement in the periapical index (PAI) score. A hard tissue barrier was detected radiographically in four cases. CONCLUSION: Full pulpotomy using Biodentine was a successful treatment option for cariously exposed pulps in mature permanent molar teeth with clinical signs and symptoms indicative of irreversible pulpitis, up to 1 year.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1111/iej.12903

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[PMID]: 29480930
[Au] Autor:Pulikkotil SJ; Nagendrababu V; K Veettil S; Jinatongthai P; Setzer FC
[Ad] Address:Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
[Ti] Title:Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis- A systematic review and network meta-analysis of randomized controlled trials.
[So] Source:Int Endod J;, 2018 Feb 26.
[Is] ISSN:1365-2591
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This systematic review (SR; PROSPERO database: CRD42017075160) and network meta-analysis (NMA) identified the most effective oral premedication for anaesthetic success of inferior alveolar nerve blocks (IANB) in cases of irreversible pulpitis. Medline and Ebscohost databases were searched up until 10/2017. Randomized controlled trials (RCT) studying the effect of oral premedication, alone or in combination, on the success of IANB for cases of irreversible pulpitis, compared to placebo or other oral premedications, were included. Quality of the included studies was appraised by the revised Cochrane risk of bias tool for randomized trials. Pairwise analysis, NMA, and quality of evidence assessment using GRADE criteria was performed. Nineteen studies (n=1654 participants) were included. NMA demonstrated that, compared to placebo, dexamethasone was most effective in increasing anaesthetic success (RR, 2.92 [95%CI 1.74,4.91]; SUCRA=0.96), followed by NSAIDs (RR, 1.92 [95%CI 1.63,2.27], SUCRA=0.738), and Tramadol (RR, 2.03 [95%CI 1.18,3.49], SUCRA=0.737). Premedication with acetaminophen added to NSAIDs demonstrated similar efficacy as NSAIDs alone (RR, 1.06 [95% CI 0.79,1.43]). Sensitivity analyses proved the superiority of dexamethasone or NSAIDs over any other premedications. Subgroup analyses of specific dosages in comparison to placebo demonstrated that dexamethasone 0.5mg was most effective, followed by ketorolac 10mg, piroxicam 20mg, ibuprofen 400mg + acetaminophen 500mg and Tramadol 50mg. Ibuprofen 400mg, 600mg and 800mg had a significantly improved IANB success, while Ibuprofen 300mg had no effect. Oral premedication with dexamethasone, NSAIDs or Tramadol significantly increased anaesthetic success. More trials are needed to evaluate the premedication effects of dexamethasone or Tramadol for improved anaesthetic success of IANB when treating irreversible pulpitis. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1111/iej.12912

  10 / 2950 MEDLINE  
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[PMID]: 29479030
[Au] Autor:Watase T; Shimizu K; Komiya H; Ohara K; Iwata K; Ogiso B
[Ad] Address:Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry.
[Ti] Title:Involvement of transient receptor potential vanilloid 1 channel expression in orofacial cutaneous hypersensitivity following tooth pulp inflammation.
[So] Source:J Oral Sci;, 2018 Feb 26.
[Is] ISSN:1880-4926
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A study was conducted to evaluate the mechanisms underlying ectopic orofacial pain associated with tooth pulp inflammation in rats. We observed a significant decrease in the head withdrawal threshold (HWT) response to mechanical and heat stimuli applied to the ipsilateral facial skin upon application of complete Freund's adjuvant (CFA) to the upper first molar (M1TP) in comparison to application of vehicle. A large number of trigeminal ganglion (TG) neurons showed transient receptor potential vanilloid 1 (TRPV1) immunoreactivity (IR), and some of them were retrogradely labeled with fluorogold injected into the facial skin. A large number of cells showing IR for glial fibrillary acidic protein (GFAP) were observed in the 2nd compared to the 1st or 3rd branch regions of the TG, and TG cells innervating the facial skin were also surrounded by GFAP-IR cells. After administration of TRPV1 antagonist into the facial skin of M1TP CFA-treated rats, the decrease of HWTs in response to mechanical and heat stimulation of the facial skin was significantly reversed. The present findings suggest that the excitability of TG neurons is enhanced upon tooth pulp inflammation, leading to overexpression of TRPV1 in TG neurons innervating the facial skin, and that satellite glial cells are also activated, resulting in the development of ectopic orofacial pain.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.2334/josnusd.16-0854


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