Database : MEDLINE
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[PMID]: 29511734
[Au] Autor:Zhao Q; Huang W; Luo Z; Liu L; Lu Y; Li Y; Li L; Hu J; Ma H; Chen J
[Ad] Address:State Key Laboratory of Elemento-Organic Chemistry and Key Laboratory of Advanced Energy Materials Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
[Ti] Title:High-capacity aqueous zinc batteries using sustainable quinone electrodes.
[So] Source:Sci Adv;4(3):eaao1761, 2018 Mar.
[Is] ISSN:2375-2548
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Quinones, which are ubiquitous in nature, can act as sustainable and green electrode materials but face dissolution in organic electrolytes, resulting in fast fading of capacity and short cycle life. We report that quinone electrodes, especially calix[4]quinone (C4Q) in rechargeable metal zinc batteries coupled with a cation-selective membrane using an aqueous electrolyte, exhibit a high capacity of 335 mA h g with an energy efficiency of 93% at 20 mA g and a long life of 1000 cycles with a capacity retention of 87% at 500 mA g . The pouch zinc batteries with a respective depth of discharge of 89% (C4Q) and 49% (zinc anode) can deliver an energy density of 220 Wh kg by mass of both a C4Q cathode and a theoretical Zn anode. We also develop an electrostatic potential computing method to demonstrate that carbonyl groups are active centers of electrochemistry. Moreover, the structural evolution and dissolution behavior of active materials during discharge and charge processes are investigated by operando spectral techniques such as IR, Raman, and ultraviolet-visible spectroscopies. Our results show that batteries using quinone cathodes and metal anodes in aqueous electrolyte are reliable approaches for mass energy storage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1126/sciadv.aao1761

  2 / 12140 MEDLINE  
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[PMID]: 29239081
[Au] Autor:Egner JM; Jensen DR; Olp MD; Kennedy NW; Volkman BF; Peterson FC; Smith BC; Hill RB
[Ad] Address:Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
[Ti] Title:Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy.
[So] Source:Chembiochem;19(5):448-458, 2018 Mar 02.
[Is] ISSN:1439-7633
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:An academic chemical screening approach was developed by using 2D protein-detected NMR, and a 352-chemical fragment library was screened against three different protein targets. The approach was optimized against two protein targets with known ligands: CXCL12 and BRD4. Principal component analysis reliably identified compounds that induced nonspecific NMR crosspeak broadening but did not unambiguously identify ligands with specific affinity (hits). For improved hit detection, a novel scoring metric-difference intensity analysis (DIA)-was devised that sums all positive and negative intensities from 2D difference spectra. Applying DIA quickly discriminated potential ligands from compounds inducing nonspecific NMR crosspeak broadening and other nonspecific effects. Subsequent NMR titrations validated chemotypes important for binding to CXCL12 and BRD4. A novel target, mitochondrial fission protein Fis1, was screened, and six hits were identified by using DIA. Screening these diverse protein targets identified quinones and catechols that induced nonspecific NMR crosspeak broadening, hampering NMR analyses, but are currently not computationally identified as pan-assay interference compounds. The results established a streamlined screening workflow that can easily be scaled and adapted as part of a larger screening pipeline to identify fragment hits and assess relative binding affinities in the range of 0.3-1.6 mm. DIA could prove useful in library screening and other applications in which NMR chemical shift perturbations are measured.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1002/cbic.201700386

  3 / 12140 MEDLINE  
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[PMID]: 29523543
[Au] Autor:Becker KW; Elling FJ; Schröder JM; Lipp JS; Goldhammer T; Zabel M; Elvert M; Overmann J; Hinrichs KU
[Ad] Address:Organic Geochemistry Group, MARUM - Center for Marine Environmental Sciences & Department of Geosciences, University of Bremen, 28359 Bremen, Germany kbecker@whoi.edu felix_elling@fas.harvard.edu.
[Ti] Title:Isoprenoid quinones resolve the stratification of microbial redox processes in a biogeochemical continuum from the photic zone to deep anoxic sediments of the Black Sea.
[So] Source:Appl Environ Microbiol;, 2018 Mar 09.
[Is] ISSN:1098-5336
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The stratified water column of the Black Sea serves as a model ecosystem for studying the interactions of microorganisms with major biogeochemical cycles. Here we provide detailed analysis of isoprenoid quinones to study microbial redox processes in the ocean. In a continuum from the photic zone through the chemocline into deep anoxic sediments of the southern Black Sea, diagnostic quinones and inorganic geochemical parameters indicate niche segregation between redox processes and corresponding shifts in microbial community composition. Quinones specific for oxygenic photosynthesis and aerobic respiration dominate oxic waters, while quinones associated with thaumarchaeal ammonia-oxidation and bacterial methanotrophy, respectively, dominate a narrow interval in suboxic waters. Quinone distributions indicate highest metabolic diversity within the anoxic zone, with anoxygenic photosynthesis being a major process in its photic layer. In the dark anoxic layer, quinone profiles indicate occurrence of bacterial sulfur and nitrogen cycling, archaeal methanogenesis, and archaeal methanotrophy. Multiple novel ubiquinone isomers, possibly originating from unidentified intra-aerobic anaerobes, occur in this zone. The respiration modes found in the anoxic zone continue into shallow subsurface sediments, but quinone abundances rapidly decrease within the upper 50 cm below sea floor, reflecting the transition to lower energy availability. In the deep subseafloor sediments, quinone distributions and geochemical profiles indicate archaeal methanogenesis/methanotrophy and potentially bacterial fermentative metabolisms. We observed that sedimentary quinone distributions track lithology, which supports prior hypotheses that deep biosphere community composition and metabolisms are determined by environmental conditions during sediment deposition. Microorganisms play crucial roles in global biogeochemical cycles. Yet, we have only a fragmentary understanding of the diversity of microorganisms and their metabolisms, as the majority remains uncultured. Thus, culture-independent approaches are critical for determining microbial diversity and active metabolic processes. In order to resolve the stratification of microbial communities in the Black Sea, we comprehensively analyzed redox process-specific isoprenoid quinone biomarkers in a unique continuous record from the photic zone through the chemocline into anoxic subsurface sediments. We describe an unprecedented quinone diversity that allowed us to detect distinct biogeochemical processes including oxygenic photosynthesis, archaeal ammonia oxidation, aerobic methanotrophy and anoxygenic photosynthesis in defined geochemical zones.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 12140 MEDLINE  
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[PMID]: 29458462
[Au] Autor:Wang C; Huang Y; Li L; Guo J; Wu Z; Deng Y; Dai L; Ma S
[Ad] Address:1​Biogas Institute of Ministry of Agriculture, Chengdu 610041, PR China.
[Ti] Title:Lactobacillus panisapium sp. nov., from honeybee Apis cerana bee bread.
[So] Source:Int J Syst Evol Microbiol;68(3):703-708, 2018 Mar.
[Is] ISSN:1466-5034
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A novel facultatively anaerobic, Gram-stain-positive, non-motile, non-spore-forming, catalase-negative bacterium of the genus Lactobacillus, designated strain Bb 2-3 , was isolated from bee bread of Apis cerana collected from a hive in Kunming, China. The strain was regular rod-shaped. Optimal growth occurred at 37 °C, pH 6.5 with 5.0 g l NaCl. The predominant fatty acids were C18 : 1ω9c, C16 : 0 and C19 : 0 iso. Respiratory quinones were not detected. Seven glycolipids, three lipids, phosphatidylglycerol and diphosphatidylglycerol were detected. The peptidoglycan type A4α l-Lys-d-Asp was determined. Strain Bb 2-3 was closely related to Lactobacillus bombicola DSM 28793 , Lactobacillus apis LMG 26964 and Lactobacillus helsingborgensis DSM 26265 , with 97.8, 97.6 and 97.0 % 16S rRNA gene sequence similarity, respectively. A comparison of two housekeeping genes, rpoA and pheS, revealed that strain Bb 2-3 was well separated from the reference strains of species of the genus Lactobacillus. The average nucleotide identity between strain Bb 2-3 and the type strains of closely related species was lower than the 95-96 % threshold value for delineation of genomic prokaryotic species. The G+C content of the genomic DNA of strain Bb 2-3 was 37.4 mol%. On the basis of phenotypic, chemotaxonomic and phylogenetic analyses, strain Bb 2-3 is proposed to represent a novel species of the genus Lactobacillus, for which we propose the name Lactobacillus panisapium sp. nov. The type strain is Bb 2-3 (=DSM 102188 =ACCC 19955 ).
[Mh] MeSH terms primary: Bees/microbiology
Lactobacillus/classification
Phylogeny
Propolis
[Mh] MeSH terms secundary: Animals
Bacterial Typing Techniques
Base Composition
China
DNA, Bacterial/genetics
Fatty Acids/chemistry
Glycolipids/chemistry
Lactobacillus/genetics
Lactobacillus/isolation & purification
Peptidoglycan/chemistry
Phospholipids/chemistry
RNA, Ribosomal, 16S/genetics
Sequence Analysis, DNA
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Glycolipids); 0 (Peptidoglycan); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 9009-62-5 (Propolis)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180221
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002538

  5 / 12140 MEDLINE  
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[PMID]: 29450434
[Au] Autor:Jardim GAM; Oliveira WXC; de Freitas RP; Menna-Barreto RFS; Silva TL; Goulart MOF; da Silva Júnior EN
[Ad] Address:Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. eufranio@ufmg.br.
[Ti] Title:Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones.
[So] Source:Org Biomol Chem;16(10):1686-1691, 2018 Mar 07.
[Is] ISSN:1477-0539
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We report a sequential C-H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1039/c8ob00196k

  6 / 12140 MEDLINE  
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[PMID]: 29420036
[Au] Autor:Kondo T; Matsuoka M; Azai C; Kobayashi M; Itoh S; Oh-Oka H
[Ad] Address:Division of Material Science (Physics), Graduate School of Science , Nagoya University , Furocho, Chikusa , Nagoya 464-8602 , Japan.
[Ti] Title:Light-Induced Electron Spin-Polarized (ESP) EPR Signal of the P800 Menaquinone Radical Pair State in Oriented Membranes of Heliobacterium modesticaldum: Role/Location of Menaquinone in the Homodimeric Type I Reaction Center.
[So] Source:J Phys Chem B;122(9):2536-2543, 2018 Mar 08.
[Is] ISSN:1520-5207
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Function/location of menaquinone (MQ) was studied in the photosynthetic reaction center of Heliobacterium (Hbt.) modesticaldum (hRC), which is one of the most primitive homodimeric type I RCs. The spin-polarized electron paramagnetic resonance signals of light-induced radical pair species, which are made of oxidized electron donor bacteriochlorophyll g (P800 ) and reduced menaquinone (MQ ) or iron-sulfur cluster (F ), were measured in the oriented membranes of Hbt. modesticaldum at cryogenic temperature. The spectral shape of transient electron spin-polarized signal of P800 F radical pair state varied little with respect to the direction of the external magnetic field. It suggested a dominant contribution of the spin evolution on the precursor primary radical pair P800 A state with the larger isotropic magnetic exchange interaction J than the anisotropic dipole interaction D. The pure P800 MQ signal was simulated by subtracting the effects of spin evolution during the electron-transfer process. It was concluded that the J value of the P800 MQ radical pair is negative with an amplitude almost comparable to | D|. It is in contrast to a positive and small J value of the P700 PhyQ state in photosystem I (PS I). The results indicate similar but somewhat different locations/binding sites of quinones between hRC and PS I.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.jpcb.7b12171

  7 / 12140 MEDLINE  
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[PMID]: 29506390
[Au] Autor:Vyas P; Yadav DK; Khandelwal P
[Ad] Address:a Department of Chemistry , Mohanlal Sukhadia University , Udaipur , India.
[Ti] Title:Tectona grandis (teak) - A review on its phytochemical and therapeutic potential.
[So] Source:Nat Prod Res;:1-17, 2018 Mar 06.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tectona grandis Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, lapachol and deoxylapachol. Naphthoquinones, anthraquinones and isoprenoid quinones are abundant metabolites in teak. In addition to these, teak contains several other phytochemicals such as triterpenoids, steroids, lignans, fatty esters and phenolic compounds. Pharmacologically, the plant has been investigated for antioxidant, anti-inflammatory, anti-pyretic, cytotoxic, analgesic, hypoglycemic, wound healing and antiplasmodial activities. The present review highlights the phytochemical and pharmacological aspects of teak.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1440217

  8 / 12140 MEDLINE  
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[PMID]: 29325221
[Au] Autor:Molee W; Phanumartwiwath A; Kesornpun C; Sureram S; Ngamrojanavanich N; Ingkaninan K; Mahidol C; Ruchirawat S; Kittakoop P
[Ad] Address:Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok, 10210, Thailand.
[Ti] Title:Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging, Antioxidant, Cytotoxic, Antibacterial, and Phosphodiesterase Inhibitory Activities.
[So] Source:Chem Biodivers;, 2018 Jan 11.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:New naphthalene derivatives (1 and 2) and a new isomer (3) of ventilagolin, together with known anthraquinones, chrysophanol (4), physcion or emodin 3-methyl ether (5), and emodin (6), were isolated from vines of Ventilago denticulata. The isolated compounds exhibited cytotoxic activity with IC values of 1.15 - 40.54 µg/ml. Compounds 1 - 3 selectively exhibited weak antibacterial activity (MIC values of 200.0 - 400.0 µg/ml), while emodin (6) displayed moderate antibacterial activity with MIC value of 25.0 µg/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 - 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin (6) acted as an aromatase inhibitor with the IC value of 10.1 µm. Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC values of 8.28 µm and 6.48 µm, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher
[do] DOI:10.1002/cbdv.201700537

  9 / 12140 MEDLINE  
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[PMID]: 28468657
[Au] Autor:Pei JP; Fan LH; Nan K; Li J; Dang XQ; Wang KZ
[Ad] Address:Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, 710004, Shaanxi Province, People's Republic of China.
[Ti] Title:HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.
[So] Source:J Neuroinflammation;14(1):97, 2017 May 03.
[Is] ISSN:1742-2094
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mechanism of HSYA is not fully elucidated. The present study investigated the protective effects of HSYA in rat spinal cord compression injury model and related mechanisms involved. METHODS: Sprague-Dawley rats were divided as Sham, Control, and HSYA groups (n = 30 per group). Spinal cord injury (SCI) model was induced by application of vascular clips (force of 50 g, 1 min) to the dura at T9-T10 level of vertebra. Injured animals were administered with either HSYA (8 mg/kg at 1 and 6 h after injury, then 14 mg/kg, for a total of 7 days at 24-h time intervals) or equal volume of saline by intraperitoneal injection. RESULTS: From this experiment, we discovered that SCI in rats resulted in severe trauma, which is characterized by tissue damage, lipid peroxidation, neutrophil infiltration, inflammation mediator release, and neuronal apoptosis. However, HSYA treatment significantly reduced the following: (1) degree of tissue injury (histological score) and edema; (2) neutrophil infiltration (myeloperoxidase activity); (3) oxidative stress (superoxide dismutase, malondialdehyde, and nitric oxide); (4) pro-inflammatory cytokine expression (tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2); (5) nuclear factor-κB activation; (6) apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labeling staining and cysteine-aspartic protease-3 activity). Moreover, in a separate set of experiments, we clearly demonstrated that HSYA treatment significantly ameliorated recovery of limb function (as evaluated by Basso, Beattie, and Bresnahan behavioral recovery scores). CONCLUSIONS: Treatment with HSYA restrains development of oxidative stress, inflammation response, and apoptotic events associated with SCI of rats, demonstrating that HSYA is a potential neuroprotectant for human SCI therapy.
[Mh] MeSH terms primary: Apoptosis/physiology
Chalcone/analogs & derivatives
Inflammation Mediators/metabolism
Neurons/metabolism
Oxidative Stress/physiology
Quinones/therapeutic use
Spinal Cord Compression/metabolism
[Mh] MeSH terms secundary: Animals
Apoptosis/drug effects
Cell Death/drug effects
Cell Death/physiology
Chalcone/pharmacology
Chalcone/therapeutic use
Inflammation Mediators/antagonists & inhibitors
Male
Neurons/drug effects
Neurons/pathology
Oxidative Stress/drug effects
Pigments, Biological/pharmacology
Pigments, Biological/therapeutic use
Quinones/pharmacology
Rats
Rats, Sprague-Dawley
Spinal Cord Compression/drug therapy
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Inflammation Mediators); 0 (Pigments, Biological); 0 (Quinones); 146087-19-6 (hydroxysafflor yellow A); 5S5A2Q39HX (Chalcone)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0870-1

  10 / 12140 MEDLINE  
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[PMID]: 29498051
[Au] Autor:Cui S; Wada S; Tobimatsu Y; Takeda Y; Saucet SB; Takano T; Umezawa T; Shirasu K; Yoshida S
[Ad] Address:Graduate School of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
[Ti] Title:Host lignin composition affects haustorium induction in the parasitic plants Phtheirospermum japonicum and Striga hermonthica.
[So] Source:New Phytol;, 2018 Mar 02.
[Is] ISSN:1469-8137
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Parasitic plants in the family Orobanchaceae are destructive weeds of agriculture worldwide. The haustorium, an essential parasitic organ used by these plants to penetrate host tissues, is induced by host-derived phenolic compounds called haustorium-inducing factors (HIFs). The origin of HIFs remains unknown, although the structures of lignin monomers resemble that of HIFs. Lignin is a natural phenylpropanoid polymer, commonly found in secondary cell walls of vascular plants. We therefore investigated the possibility that HIFs are derived from host lignin. Various lignin-related phenolics, quinones and lignin polymers, together with nonhost and host plants that have different lignin compositions, were tested for their haustorium-inducing activity in two Orobanchaceae species, a facultative parasite, Phtheirospermum japonicum, and an obligate parasite, Striga hermonthica. Lignin-related compounds induced haustoria in P. japonicum and S. hermonthica with different specificities. High concentrations of lignin polymers induced haustorium formation. Treatment with laccase, a lignin degradation enzyme, promoted haustorium formation at low concentrations. The distinct lignin compositions of the host and nonhost plants affected haustorium induction, correlating with the response of the different parasitic plants to specific types of lignin-related compounds. Our study provides valuable insights into the important roles of lignin biosynthesis and degradation in the production of HIFs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1111/nph.15033


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