Database : MEDLINE
Search on : Radial and Neuropathy [Words]
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[PMID]: 29367382
[Au] Autor:Ackerman SD; Luo R; Poitelon Y; Mogha A; Harty BL; D'Rozario M; Sanchez NE; Lakkaraju AKK; Gamble P; Li J; Qu J; MacEwan MR; Ray WZ; Aguzzi A; Feltri ML; Piao X; Monk KR
[Ad] Address:Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO.
[Ti] Title:GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.
[So] Source:J Exp Med;215(3):941-961, 2018 Mar 05.
[Is] ISSN:1540-9538
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Myelin is a multilamellar sheath generated by specialized glia called Schwann cells (SCs) in the peripheral nervous system (PNS), which serves to protect and insulate axons for rapid neuronal signaling. In zebrafish and rodent models, we identify GPR56/ADGRG1 as a conserved regulator of PNS development and health. We demonstrate that, during SC development, GPR56-dependent RhoA signaling promotes timely radial sorting of axons. In the mature PNS, GPR56 is localized to distinct SC cytoplasmic domains, is required to establish proper myelin thickness, and facilitates organization of the myelin sheath. Furthermore, we define plectin-a scaffolding protein previously linked to SC domain organization, myelin maintenance, and a series of disorders termed "plectinopathies"-as a novel interacting partner of GPR56. Finally, we show that mutants develop progressive neuropathy-like symptoms, suggesting an underlying mechanism for peripheral defects in some human patients with mutations. In sum, we define Gpr56 as a new regulator in the development and maintenance of peripheral myelin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.1084/jem.20161714

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[PMID]: 29506771
[Au] Autor:Karakis I; Georghiou S; Jones HR; Darras BT; Kang PB
[Ad] Address:Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, Lahey Clinic, Burlington, Massachusetts; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia.
[Ti] Title:Electrophysiologic Features of Radial Neuropathy in Childhood and Adolescence.
[So] Source:Pediatr Neurol;, 2018 Jan 31.
[Is] ISSN:1873-5150
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: We analyzed the clinical and electrophysiologic patterns of nerve injury in pediatric patients with radial neuropathy. METHODS: This is a retrospective analysis of 19 children and adolescents with radial neuropathy. RESULTS: The mean subject age was 12 years (range one month to 19 years), 56% were female, and 53% had traumatic etiologies. Weakness in the finger and wrist extensors was the prevailing complaint (82%). Predominant localization was at the posterior interosseous nerve (37%), followed by the radial nerve below the spiral groove (32%), the radial nerve at the spiral groove (26%), and the radial nerve above the spiral groove (5%). Extensor indicis proprius compound muscle action potential amplitude was reduced in 86% of cases when tested, with a median axon loss estimate of 78%. The radial sensory nerve action potential amplitude was reduced in 53% of all cases, and in 83% of cases affecting the main radial trunk with a median axon loss estimate of 100%. For cases affecting the main radial trunk, there was a high correlation of extensor indicis proprius median axon loss estimate and radial sensory nerve action potential median axon loss estimate (r=0.72, P=0.02). Neurogenic changes were seen in the extensor indicis proprius, extensor digitorum communis, extensor carpi radialis, and brachioradialis in 88%, 94%, 60%, and 44% of cases, respectively. Pathophysiology was demyelinating in 10%, axonal in 58%, and mixed in 32%. CONCLUSIONS: In contrast to adults, where localization at the spiral groove predominates, radial neuropathy in children and adolescents is commonly localized at the posterior interosseous nerve or at the distal main radial trunk. Pediatric radial neuropathy is frequently of traumatic etiology and axonal pathophysiology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  3 / 2152 MEDLINE  
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[PMID]: 29480857
[Au] Autor:Shi M; Qi H; Ding H; Chen F; Xin Z; Zhao Q; Guan S; Shi H
[Ad] Address:Department of Ultrasound, Qianfoshan Hospital Affiliated to Shandong University, Jinan.
[Ti] Title:Electrophysiological examination and high frequency ultrasonography for diagnosis of radial nerve torsion and compression.
[So] Source:Medicine (Baltimore);97(2):e9587, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study aims to evaluate the value of electrophysiological examination and high frequency ultrasonography in the differential diagnosis of radial nerve torsion and radial nerve compression.Patients with radial nerve torsion (n = 14) and radial nerve compression (n = 14) were enrolled. The results of neurophysiological and high frequency ultrasonography were compared.Electrophysiological examination and high-frequency ultrasonography had a high diagnostic rate for both diseases with consistent results. Of the 28 patients, 23 were positive for electrophysiological examination, showing decreased amplitude and decreased conduction velocity of radial nerve; however, electrophysiological examination cannot distinguish torsion from compression. A total of 27 cases showed positive in ultrasound examinations among all 28 cases. On ultrasound images, the nerve was thinned at torsion site whereas thickened at the distal ends of torsion. The diameter and cross-sectional area of torsion or compression determined the nerve damage, and ultrasound could locate the nerve injury site and measure the length of the nerve.Electrophysiological examination and high-frequency ultrasonography can diagnose radial neuropathy, with electrophysiological examination reflecting the neurological function, and high-frequency ultrasound differentiating nerve torsion from compression.
[Mh] MeSH terms primary: Electrodiagnosis
Nerve Compression Syndromes/diagnosis
Radial Nerve/diagnostic imaging
Radial Nerve/physiopathology
Radial Neuropathy/diagnosis
Ultrasonography
[Mh] MeSH terms secundary: Adolescent
Adult
Diagnosis, Differential
Female
Humans
Male
Nerve Compression Syndromes/physiopathology
Nerve Compression Syndromes/surgery
Neural Conduction
Radial Nerve/surgery
Radial Neuropathy/physiopathology
Radial Neuropathy/surgery
Treatment Outcome
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009587

  4 / 2152 MEDLINE  
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[PMID]: 29169591
[Au] Autor:Chang G; Ilyas AM
[Ad] Address:Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA. Electronic address: gerard.chang@gmail.com.
[Ti] Title:Radial Nerve Palsy After Humeral Shaft Fractures: The Case for Early Exploration and a New Classification to Guide Treatment and Prognosis.
[So] Source:Hand Clin;34(1):105-112, 2018 02.
[Is] ISSN:1558-1969
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Radial nerve palsies are a common complication associated with humeral shaft fractures. The authors propose classifying these injuries into 4 types based on intraoperative findings: type 1 stretch/neuropraxia, type 2 incarcerated, type 3 partial transection, and type 4 complete transection. The initial management of radial nerve palsies associated with closed fractures of the humerus remains a controversial topic, with early exploration reserved for open fractures, fractures that cannot achieve an adequate closed reduction requiring fracture repair, fractures with associated vascular injuries, and polytrauma patients. Outside of these recommendations, expectant observation for spontaneous recovery is recommended.
[Mh] MeSH terms primary: Humeral Fractures/complications
Humeral Fractures/surgery
Radial Neuropathy/classification
Radial Neuropathy/surgery
[Mh] MeSH terms secundary: Fracture Fixation, Internal/adverse effects
Humans
Prognosis
Radial Nerve/anatomy & histology
Radial Neuropathy/diagnosis
Radial Neuropathy/etiology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[Js] Journal subset:IM
[Da] Date of entry for processing:171125
[St] Status:MEDLINE

  5 / 2152 MEDLINE  
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[PMID]: 29490340
[Au] Autor:Augstburger E; Zboulon P; Keilani C; Baudouin C; Labb A
[Ad] Address:Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France.
[Ti] Title:Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study.
[So] Source:Invest Ophthalmol Vis Sci;59(2):870-877, 2018 Feb 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods: In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of symptoms) and normal subjects underwent a complete ophthalmic examination including spectral-domain OCT, visual field (VF), and OCT-A. Whole en face image vessel density (wiVD) was used to assess retinal blood flow of the radial peripapillary capillaries (RPCs), circumpapillary RPC vessel density (cpVD), superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). Statistical correlations between wiVD measurements and visual acuity, VF parameters, retinal nerve fiber layer (RNFL), and combined thickness of retinal ganglion cell and inner plexiform layers were analyzed. Results: Twenty-four patients (26 eyes) with NAION and 24 age-matched normal controls (NCs) (24 eyes) were included. OCT-A showed significant reduction of the RPC wiVD (P < 0.0001) and the cpVD (P < 0.0001) in NAION eyes compared with NC and correlated with RNFL thickness (P = 0.002, P = 0.004), visual acuity (P = 0.042), and mean deviation of the VF (P = 0.001). Macular OCT angiograms showed capillary rarefaction in the SCP (P < 0.0001) and DCP (P < 0.0001) in the NAION group, both correlated with visual acuity (P = 0.02, P = 0.024). However, wiVD of the CC was not significantly different between the two groups in the peripapillary (P = 0.218) and macular (P = 0.786) areas. Conclusions: OCT-A provided detailed visualization of the peripapillary and macular retinal capillary rarefaction, correlated with VF and visual acuity loss. OCT-A could be a useful tool for quantifying and monitoring ischemia in NAION.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review
[do] DOI:10.1167/iovs.17-22996

  6 / 2152 MEDLINE  
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[PMID]: 29455401
[Au] Autor:Wang Y; Dong Q; Li SJ; Hu WL
[Ad] Address:Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China.
[Ti] Title:New clinical characteristics and risk factors of hand knob infarction.
[So] Source:Neurol Sci;, 2018 Feb 17.
[Is] ISSN:1590-3478
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Hand knob infarction (HKI) is a rare clinical condition which is often misdiagnosed as peripheral neuropathy. This study aimed to identify the clinical characteristics and risk factors of HKI. Nine HKI patients admitted between January 2013 and March 2016 were confirmed by magnetic resonance imaging. Their medical records were collected and analyzed. The modified Rankin Scale was used to assess clinical outcomes. Routine laboratory tests, electrocardiogram, echocardiography, cranial magnetic resonance imaging, magnetic resonance angiography, computed tomography angiography, and Doppler ultrasonography examinations were performed. Seven patients had uniform involvement of all digits. One patient with radial weakness had a lesion in the lateral area of hand knob, and another patient with ulnar weakness had a lesion distributed in the medial area of hand knob. Hyperhomocysteinemia was a most common risk factor for HKI. Most HKI patients had a benign disease course, but three patients (33.33%) with the stroke type of large artery atherosclerosis had disease recurrence. We characterized clinical characteristics and risk factors of HKI which will help the diagnosis and management of HKI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher
[do] DOI:10.1007/s10072-018-3278-5

  7 / 2152 MEDLINE  
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[PMID]: 29451992
[Au] Autor:Mastropasqua R; Agnifili L; Borrelli E; Fasanella V; Brescia L; Antonio LD; Mastropasqua L
[Ad] Address:a Ophthalmology Clinic , Moorfields Eye Hospital , London , UK.
[Ti] Title:Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy.
[So] Source:Curr Eye Res;:1-7, 2018 Feb 16.
[Is] ISSN:1460-2202
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To analyze the retinal radial peripapillary capillary (RPC) network in normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) eyes using optical coherence tomography angiography (OCTA). MATERIAL AND METHODS: Twenty-two patients with NTG, 22 patients with unilateral chronic NAION, and 23 age-matched controls were enrolled. Patients underwent OCTA to obtain en face angiograms of the peripapillary region. The main outcome measures were as follows: (1) the whole en face image perfusion density (WPD) and (2) the circumpapillary perfusion density (CPD). RESULTS: Mean SD age was 66.37.0years in the NTG group, 68.14.3years in the NAION group, and 63.97.0years in the control group (p>0.05 for all the comparisons). The visual field mean defect (MD) was worse in patients than in controls (p<0.0001), but did not differ between NTG and NAION (-9.62.6 dB and -8.22.6 dB, respectively). The WPD was 0.410.04 in the NTG group (p<0.0001 in comparison with healthy subjects and NAION patients), 0.460.04 in the NAION group (p<0.0001 in comparison with the control group), and 0.560.03 in the control group. The CPD was significantly reduced in both NTG (0.480.04, p<0.0001) and NAION eyes (0.520.05, p<0.0001), after comparison to control eyes (0.590.03). Moreover, the CPD was significantly lower in NTG than in NAION eyes (p=0.006). CONCLUSIONS: OCTA documented a reduction of the peripapillary perfusion in NTG and unilateral NAION. In presence of similar functional damage, the lower perfusion densities in NTG may indicate greater vascular alterations in chronic compared to acute ischemic optic neuropathies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1080/02713683.2018.1438630

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[PMID]: 29409421
[Au] Autor:Irifune H; Takahashi N; Hirayama S; Narimatsu E; Yamashita T
[Ad] Address:* Departments of Emergency Medicine, Sapporo Medical University, Sapporo, Japan.
[Ti] Title:Treatment of Hand Allodynia Resulting from Wrist Cutting with Radial and Ulnar Artery Perforator Adipofascial Flaps.
[So] Source:J Hand Surg Asian Pac Vol;23(1):116-120, 2018 Mar.
[Is] ISSN:2424-8363
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:In this article, we report two cases in which recurrent adhesive hand neuropathy with allodynia were successfully treated with radial and ulnar artery adipofascial perforator flap coverage. Treatment of recurrent neuropathy, such as recurrent carpal tunnel syndrome and re-adhesion after neurolysis using free and pedicle flaps to cover the nerves, has been reported to show good results. However, for severe painful nerve disorders, such as complex regional pain syndrome, the efficacy of this treatment was unclear. We present two cases diagnosed with recurrent adhesive hand neuropathy with allodynia, resulting from wrist cutting; these cases were treated with neurolysis and flap coverage with good results and no recurrence. This suggests that neurolysis and flap coverage are effective methods for treating complex regional pain syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process
[do] DOI:10.1142/S2424835518720025

  9 / 2152 MEDLINE  
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[PMID]: 29320503
[Au] Autor:Fard MA; Suwan Y; Moghimi S; Geyman LS; Chui TY; Rosen RB; Ritch R
[Ad] Address:Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
[Ti] Title:Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma.
[So] Source:PLoS One;13(1):e0189237, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness. METHODS: 31 chronic NAION (>6 months after the acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged with a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions. Two concentric circles of diameters 1.95mm (inner) and 3.45mm (outer) were manually placed on images centered on the optic nerve head, producing an annular region-of-interest. Image analysis with major vessel removal was performed using a custom program. Whole-image, whole-annulus, and sectoral PCDs were measured. RESULTS: Whole-image and whole-annulus PCDs in NAION and moderate and severe POAG eyes were significantly decreased compared to unaffected fellow eyes and control eyes (all P<0.001). Superior and temporal PCD values were affected more than other sectors in both NAION and POAG groups compared to control group. Whole-image and whole-annulus PCDs were not statistically different between NAION and POAG eyes (both P = 0.99). However, of all peripapillary sectors, the inferior sector PCD value was less affected in POAG eyes compared to NAION eyes (P = 0.001). Univariate analysis results also revealed a significant positive correlation between superior and inferior PCDs and corresponding RNFL thicknesses. The inferior sector correlation was greater in POAG than NAION eyes. CONCLUSION: While the whole PCD values were not different in chronic NAION and POAG, the greater correlation of inferior PCD with corresponding RNFL sectors in POAG compared to NAION suggests greater susceptibility of the inferior radial peripapillary capillary in the pathogenesis of POAG.
[Mh] MeSH terms primary: Capillaries/pathology
Glaucoma, Open-Angle/pathology
Optic Neuropathy, Ischemic/pathology
[Mh] MeSH terms secundary: Aged
Case-Control Studies
Female
Humans
Male
Middle Aged
Tomography, Optical Coherence
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[Js] Journal subset:IM
[Da] Date of entry for processing:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189237

  10 / 2152 MEDLINE  
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[PMID]: 29361423
[Au] Autor:Horneff JG; Pepe M; Tucker B; Tjoumakaris F; Lombardi N; Wowkanech C; Austin LS
[Ad] Address:Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.. Electronic address: jghorneff3@gmail.com.
[Ti] Title:Distal Mononeuropathy Before and After Arthroscopic Rotator Cuff Repair: AProspectiveInvestigation.
[So] Source:Arthroscopy;, 2018 Jan 17.
[Is] ISSN:1526-3231
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The purpose of this study was to characterize the occurrence of distal mononeuropathy (DMN) in patients before and after arthroscopic rotator cuff repair (RCR) as well as resolution of the symptoms. METHODS: One hundred one patients over the age of 18 undergoing arthroscopic RCR+/- concurrent procedures completed a questionnaire regarding the presence of a symptomatic DMN. Patients with history of diabetic neuropathy, cervical radiculopathy, brachial plexopathy, or Spurling sign were excluded. All patients underwent physical examination to determine the characteristics and location of symptoms. Postoperatively, patients underwent repeat examination at 2, 6, and 12weeks. RESULTS: Preoperatively, 19% (19/101) of RCR patients described DMN symptoms (9 median nerve symptoms, 5 ulnar nerve symptoms, 4 nonspecific symptoms, one with both ulnar and median nerve symptoms). Ninety percent (17/19) patients with preoperative DMN symptoms described resolution within the final 12weeks of follow-up. A portion of previously asymptomatic RCR patients (12/82) developed new DMN symptoms (6 nonspecific symptoms, 3 ulnar nerve symptoms, 2 median nerve symptoms, one radial sensory nerve symptoms) postoperatively, with 92% (11/12) having resolution by the final 12-week follow-up. At the final 12weeks, 3 RCR patients had DMN symptoms with 2 of those 3patients having their symptoms existing preoperatively. CONCLUSIONS: This study supports the hypothesis that DMN can be a preexisting finding in patients undergoing arthroscopic RCR. Similarly, it is common for patients undergoing arthroscopic RCR to develop new DMN symptoms following their procedure. Regardless, there is good evidence to show that a large majority of both groups of patients will go on to have resolution of their symptoms. LEVEL OF EVIDENCE: Level IV, prospective case series.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:Publisher


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