Database : MEDLINE
Search on : Respiratory and Hypersensitivity [Words]
References found : 18246 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 1825 go to page                         

  1 / 18246 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29522876
[Au] Autor:Rai ZL; Fowles HE; Wright C; Joseph H; Morice AH
[Ad] Address:Castle Hill Hospital, Clinical Trials Unit, Castle Hill Hospital Cottingham, Cottingham, HU16 5JQ, UK. Electronic address: Zainab.rai@nhs.net.
[Ti] Title:The Effect of pH on Citric Acid Cough Challenge: A Randomised Control Trial in Chronic Cough and Healthy Volunteers.
[So] Source:Respir Physiol Neurobiol;, 2018 Mar 06.
[Is] ISSN:1878-1519
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Citric acid has been used for over six decades to induce cough; however the mechanism of its pro-tussive effect is still not fully understood. We assessed the response to inhalation of citric acid at varying levels of acidity to determine if the pH of the solution plays a role in the induction of cough. Data was collected from both healthy volunteers and patients with chronic cough. METHODS: 20 chronic cough patients and 20 healthy volunteers were recruited and underwent three cough challenges on separate days. Each visit involved 5 repeated one second inhalations of 300 mM citric acid solution. The concentration of the citrate cation remained constant, but the pH of the solution altered by the addition of sodium bicarbonate to 3, 5 and 6, representing the pK values of the individual acid moieties. The total number of coughs elicited was recorded for each inhalation. RESULTS: Two subjects withdrew and were not included in the analysis. Participants were gender matched, each group consisting of 12 females. 74% of chronic coughers coughed at pH 3 (mean coughs 16), 89% coughed at pH 5 (18) and 63% coughed at pH 6 (7). In healthy volunteers, 60% of subjects coughed at pH 3 (9), 30% of subjects coughed at pH 5 (3), and 10% of subjects coughed at pH 6 (0). Thus chronic cough patients coughed more than healthy volunteers and did not exhibit a clear pH concentration response. There was also a greater variability in their response to individual challenges.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  2 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29446576
[Au] Autor:Makarov OA; Zimina AN; Nenakhova EV
[Ti] Title:[Ambient air pollution of territories of children preschool institutions by emissions of vehicle components and health of children population].
[So] Source:Gig Sanit;95(12):1188-92, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The aim of this study was the assessment of levels of pollution of territories of preschool educational institutions (PEI) by components of vehicle emissions, in dependence on their locations relatively to highways with different traffic load and, in this regard, the assessment of children health according to the incidence on the seeking medical advice. To achieve this goal there were solved following tasks: to assess air pollution levels of PEI territories by components of vehicle emissions; to evaluate levels and the structure of morbidity rate according to seeking medical advice by children attending observed PEI. In the article there is presented the evaluation of air pollution levels of the components of vehicle emissions territories 4 PEI of the city of Irkutsk located near to highways with different intensity the road transport load. The research results were obtained with the use of «Methodics for the determination vehicle emissions for summary calculations of ambient air pollution in cities¼, which allows to determine the maximum emissions of a moving vehicle per time unit (g/s) for the main combustion components and with following use of software «Superhighway -city¼ to calculate surface concentrations of considered pollutants in the surface ambient air layer (1 m) in MPC proportions. The highest levels of contamination on the content of nitric oxide and benzo- (a)-pyrene (4 and 6,5 MPC respectively) are registered in the territories adjacent to the PEI motorways with high load tracking. To assess the morbidity rate according to seeking medical advice by children attending PEI with different road transport load there were used records from outpatient medical cards «Medical card of the child¼ (f.112/y). Morbidity rate according to seeking medical advice was evaluated in dynamics throughout five years and calculated per 1000 cases. The total sample size accounted for 670 children. The highest morbidity incidence rate levels according both to seeking medical advice and the class of respiratory diseases were recorded in PEI located in close proximity to the highway with a high load of vehicle transport.
[Mh] MeSH terms primary: Air Pollution
Environmental Illness
Particulate Matter
School Health Services
Vehicle Emissions
[Mh] MeSH terms secundary: Air Pollution/adverse effects
Air Pollution/analysis
Air Pollution/prevention & control
Automobiles/classification
Automobiles/standards
Benzo(a)pyrene/analysis
Child Health
Child, Preschool
Environmental Illness/diagnosis
Environmental Illness/epidemiology
Environmental Illness/etiology
Environmental Illness/prevention & control
Environmental Monitoring/methods
Environmental Pollution/adverse effects
Environmental Pollution/analysis
Environmental Pollution/statistics & numerical data
Humans
Nitric Oxide/analysis
Particulate Matter/adverse effects
Particulate Matter/analysis
School Health Services/organization & administration
School Health Services/statistics & numerical data
Siberia/epidemiology
Vehicle Emissions/analysis
Vehicle Emissions/prevention & control
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Particulate Matter); 0 (Vehicle Emissions); 31C4KY9ESH (Nitric Oxide); 3417WMA06D (Benzo(a)pyrene)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE

  3 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29446284
[Au] Autor:Kudaeva IV; Dyakovich OA; Beygel EA; Masnavieva LB; Naumova OV; Budarina LA
[Ti] Title:[Clinical, biochemical and allergological indices characterizing occupational diseases of the bronchial and pulmonary system in employees at aluminium production].
[So] Source:Gig Sanit;95(12):1142-5, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:There are many harmful factors that possess a damaging impact on the body of employees at aluminum production. It leads to the development of bronchial asthma (BA), chronic nonobstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD). The pathogenesis of these disorders, as well as sensitizing effect offluorine in the aluminum production is not fully understood. The purpose of this work was to study the characteristics of laboratory indices in patients with occupational diseases of the respiratory system. In workers of aluminum production with the diagnosis of occupational diseases of respiratory system (15 patients with a diagnosis of asthma, 30 CNB cases, 20 COPD patients) we evaluated the content of total protein, total cholesterol, high density lipoprotein cholesterol (HDLC), total calcium, phosphorus, ceruloplasmin, hematological indices and performed emigration of leukocytes braking test (TTEEL). Clinical and biochemical profile ofpersons with occupational asthma was characterized by a low level of total calcium and ceruloplasmin, a high concentration of phosphorus in the blood serum and inhibition of leukocyte emigration in the test with sodium fluoride. For aluminum production CNB workers characteristic active proatherogenic process was pronounced by a decrease in the HDLC level and an increase in atherogenic index; higher hematocrit value and concentration of erythrocytes, and more than 50% of cases of sensitization to the presence of sodium fluoride. COPD cases had occupational lower average concentration of hemoglobin in the erythrocyte, total protein in serum, as well as polymorphic variant response to sodium fluoride in the form of a depression and activation of leucocytes emigration.
[Mh] MeSH terms primary: Air Pollutants, Occupational
Aluminum
Asthma, Occupational
Chemical Industry
Pulmonary Disease, Chronic Obstructive
[Mh] MeSH terms secundary: Air Pollutants, Occupational/analysis
Air Pollutants, Occupational/toxicity
Aluminum/analysis
Aluminum/toxicity
Asthma, Occupational/blood
Asthma, Occupational/diagnosis
Asthma, Occupational/epidemiology
Biomarkers/analysis
Chemical Industry/methods
Chemical Industry/standards
Humans
Male
Middle Aged
Occupational Exposure/adverse effects
Occupational Exposure/analysis
Occupational Exposure/prevention & control
Occupational Health/statistics & numerical data
Pulmonary Disease, Chronic Obstructive/blood
Pulmonary Disease, Chronic Obstructive/diagnosis
Pulmonary Disease, Chronic Obstructive/epidemiology
Pulmonary Disease, Chronic Obstructive/etiology
Respiratory Hypersensitivity/blood
Respiratory Hypersensitivity/chemically induced
Respiratory Hypersensitivity/diagnosis
Siberia/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Air Pollutants, Occupational); 0 (Biomarkers); CPD4NFA903 (Aluminum)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE

  4 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29431967
[Au] Autor:Izmaylova OA; Kiku PF; Yarygina MV; Moreva VG; Ananev VY; Kosolapov AB
[Ti] Title:[Hygienic aspects of the occurrence of ecology-dependent diseases in children and adolescents of the Primorsky Krai].
[So] Source:Gig Sanit;95(11):1075-9, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:With the use of the methodology of the system approach there were obtained results of the evaluation of the occurrence of ecology-dependent diseases in children and adolescents in bioclimatic zones of the Primorsky Krai. Analysis of the prevalence of the main classes of ecologically dependent diseases according to the appealability (diseases of the respiratory system, diseases of digestive organs, diseases of blood and blood-forming organs, diseases of the circulatory system, diseases of the skin and subcutaneous tissue, diseases of the genitourinary system, neoplasms, congenital anomalies, infectious diseases) was performed with the use of official statistical report forms No. 12 (ICD-10) over the period of2000-2014. Informational Database of parameters of the environment was represented by the factor modules: 6 - sanitary, and 5-environmental ones). By means of the method of the regression analysis there was established the relationship between environmental factors and the prevalence of ecological-dependent diseases, there were calculated values of the factor loads influencing on the indices of the morbidity rate in children and adolescents. The analysis of morbidity according to classes showed that during the study period, in the total there was a gain in the indicator ecologically dependent morbidity rate in children by 33.3%, in adolescents - by 35.3%. In the children and adolescent population there are prevalent diseases of the respiratory system - 67.3% and 52.45%, respectively; further in children and adolescent groups diseases of the digestive system - 9.45% and 17.08% take place; then in the children cohort are infectious diseases, and in adolescents - diseases of the genitourinary system. The level of ecologically dependent morbidity rate is determined by the complex impact of environmental and hygienic factors, with a predominance of sanitary-hygienic component and related with it parameters of the environment of habitation, such as chemical pollution of urban areas (soil, air, water sources), nevertheless biotropic factors (temperature, humidity, fog, number of days with biologically active solar radiation) make a significant contribution. The revealed various degree of the response of children and adolescents through the prevalence rate level to the exposure of ecological and hygienic factors of environment should be taken into account in the development and carrying out medical-preventive measures.
[Mh] MeSH terms primary: Environmental Exposure
Environmental Illness
School Health Services/organization & administration
[Mh] MeSH terms secundary: Adolescent
Child
Environmental Exposure/adverse effects
Environmental Exposure/analysis
Environmental Exposure/prevention & control
Environmental Illness/epidemiology
Environmental Illness/etiology
Environmental Illness/prevention & control
Female
Health Status Disparities
Health Status Indicators
Humans
Male
Population
Prevalence
Public Health/methods
Risk Factors
Russia/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE

  5 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29310444
[Au] Autor:Oakes TMM; Skljarevski V; Zhang Q; Kielbasa W; Hodsdon ME; Detke HC; Camporeale A; Saper JR
[Ad] Address:1 Eli Lilly and Company, Indianapolis, IN, USA.
[Ti] Title:Safety of galcanezumab in patients with episodic migraine: A randomized placebo-controlled dose-ranging Phase 2b study.
[So] Source:Cephalalgia;:333102417747230, 2018 Jan 01.
[Is] ISSN:1468-2982
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background Safety findings from a Phase 2b study of galcanezumab, a humanized monoclonal antibody against calcitonin gene-related peptide, for prevention of migraine (NCT02163993) are reported here. Methods Patients aged 18-65 years with episodic migraine were evaluated in this multicenter, double-blind, randomized study. After randomization, 410 patients were administered 5, 50, 120 or 300 mg of galcanezumab or placebo subcutaneously once every 4 weeks for 12 weeks, followed by a post-treatment off-drug period lasting 12 weeks. Results Treatment-emergent adverse events (TEAEs) were primarily rated as mild to moderate. Serious adverse events reported in galcanezumab dose groups were appendicitis, Crohn's disease, suicidal ideation, and congenital ankyloglossia in an infant of a paternal pregnancy; each of these were reported by one patient. Adverse events leading to discontinuation with galcanezumab treatment were abdominal pain, visual impairment, and upper limb fracture, each reported by one patient. Treatment-emergent injection-site reactions were reported significantly more frequently ( p = 0.013) with galcanezumab (13.9%) than with placebo (5.8%). Injection-site pain was the most common injection-site reaction (galcanezumab 11.4%; placebo 2.9%, p = 0.004). Upper respiratory tract infection (galcanezumab 10.0%; placebo 8.8%) and nasopharyngitis (galcanezumab 7.0%; placebo 2.2%) also occurred more frequently with galcanezumab treatment. Potential hypersensitivity events were reported at similar frequencies in galcanezumab (3.3%) and placebo (5.1%) groups. Incidence of treatment-emergent anti-drug antibodies in galcanezumab dose groups (4.6% of patients during treatment period) did not appear to have any meaningful effects on safety, the pharmacokinetics of galcanezumab, or its ability to bind to the target ligand. Conclusion The results from this 3-month Phase 2b study support the initiation of larger Phase 3 trials of longer duration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1177/0333102417747230

  6 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29197546
[Au] Autor:Dicpinigaitis PV; Kantar A; Enilari O; Paravati F
[Ad] Address:Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY. Electronic address: pdicpin@gmail.com.
[Ti] Title:Prevalence of Arnold Nerve Reflex in Adults and Children With Chronic Cough.
[So] Source:Chest;153(3):675-679, 2018 Mar.
[Is] ISSN:1931-3543
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cough originates from stimulation of structures innervated by the vagus nerve, including the airways and distal esophagus. Arnold nerve reflex describes the induction of cough by stimulation of the external auditory canal, which is innervated by the auricular branch of the vagus. Historically, the prevalence of this reflex has been reported in the range of 2% to 3% on the basis of studies of outpatients in otolaryngology practices, but has not been investigated in healthy volunteers or in patients with chronic cough. METHODS: Two hundred adults and 100 children with chronic cough, as well as 100 adult and 100 pediatric volunteers, underwent evaluation consisting of stimulation of the external auditory canal of each ear with a cotton-tipped applicator. Cough occurring within 10 seconds of stimulation was considered induced by the intervention. RESULTS: Arnold nerve reflex was present in 25.5% of adults and 3% of children with chronic cough. The prevalence of the reflex was 2% among healthy adults and children. In adults with chronic cough, Arnold nerve reflex was observed more commonly in women (31.6%) than men (12.5%) and was unilateral in the majority of patients (90.2%). CONCLUSIONS: The greater than 12 fold prevalence of Arnold nerve reflex in adults with chronic cough compared with healthy volunteers supports the concept of cough hypersensitivity syndrome (CHS), in which vagal hypersensitivity is proposed to underlie chronic refractory cough. The absence of increased prevalence among children with chronic cough suggests that cough hypersensitivity syndrome is an acquired condition, perhaps triggered by viral respiratory infection or other environmental factor.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  7 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29510808
[Au] Autor:Blichfeldt-Eckhardt MR
[Ad] Address:mr.be@rsyd.dk.
[Ti] Title:From acute to chronic postsurgical pain: the significance of the acute pain response.
[So] Source:Dan Med J;65(3), 2018 Mar.
[Is] ISSN:2245-1919
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:The thesis comprises an overview and four papers, all published or submitted for publication in international peer-reviewed scientific journals.
 
Chronic pain after surgery is a common and debilitating complication after many types of surgery. The cause and pathology behind is still mainly uncovered, though several risk factors have been proposed. One of the strongest risk factors for persistent postsurgical pain is the intensity of the acute pain response though the mechanisms involved remain unsettled. The acute pain response consists of several different types of pain (i.e. somatic pain, visceral pain, referred pain, neuropathic pain). It's uncovered whether some components of the acute pain response are closer correlated to chronic pain than others and whether treatment of acute pain can change the risk of developing chronic pain.
 The aim of the thesis was to investigate which components of the acute pain response, was correlated to chronic postsurgical pain in patients for cholecystectomy and lobectomy.
 Furthermore, to study the type and time course of ipsilateral shoulder pain after lobectomy and whether an ultrasound-guided supraclavicular phrenic nerve block was effective in preventing acute and chronic shoulder pain after major thoracic surgery.
 Paper I is based on a prospective, observational, multicenter, cohort study, in which 100 patients for cholecystectomy was examined preoperatively, 1 week postoperatively and 3, 6, and 12 months postoperatively for pain, psychological factors and signs of hypersensitivity.
 Paper II and III are based on a prospective, observational, cohort study, in which 60 patients for lobectomy ware examined preoperatively, 4 days postoperatively and 12 months postoperatively for pain, psychological factors and signs of hypersensitivity. 
Paper IV is based on a prospective, randomized, double-blind and placebo-controlled trial, where 76 patients were randomized to receive ultrasound guided supraclavicular phrenic nerve block with a blinded study solution (ropivacaine or saline). The primary endpoint was pain within the first 6 hours after surgery. Secondary endpoints included pain the following days and after 3 months.
 
Paper I: Nine patients developed chronic unexplained pain 12 months postoperatively. In a multivariate analysis, cumulated visceral pain during the first week and number of preoperative biliary pain attacks were identified as independent risk factors for unexplained pain 12 months after surgery. There were no consistent signs of increased hypersensitivity in the referred pain area before or after the operation in patients with chronic pain. 
Paper II: Sixteen patients developed chronic pain 12 months postoperatively. In a multivariate analysis thoracic pain during activity was the only significant predictor of chronic pain 12 months after surgery. Shoulder pain, referred pain and overall pain was not significant predictors. There were no signs of general hypersensitivity 12 months after surgery. 
Paper III: Forty-seven (78%) of patients experienced postoperative shoulder pain, but only 25 patients (42%) experienced clinically relevant pain (NRS > 3). On postoperative day 4, 19 (32%) of patients suffered shoulder pain, but only 4 (7%) suffered clinically relevant pain. Only 4 patients (8%) suffered chronic shoulder pain. Ipsilateral shoulder pain of the

 
musculoskeletal type is more intense than referred ipsilateral shoulder pain, though referred shoulder pain is more common. Surgical approach was not related to incidence of shoulder pain or type of pain.
 Paper IV: Shoulder pain within 6 hours of the operation was reported in 9 patients (24%) in the treatment group versus 26 (68%) in the placebo group (p<0.0001). Absolute and relative risk reductions were 44% (95% CI 22-67%) and 65% (95% CI 41-80%), respectively. No major complications, including respiratory compromise, were observed. Subsequent treatment with a nerve catheter was effective during the first 36 hours after surgery, but because of loss of nerve catheter or early submission of patients, data concerning pain the following days and after 3 months were inconclusive.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  8 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29505280
[Au] Autor:Vasakova M; Morell F; Raghu G
[Ad] Address:Fakultni Thomayerova nemocnice s poliklinikou, 48209, Department of Respiratory Medicine, Praha, Czech Republic.
[Ti] Title:Reply from the Authors of "Hypersensitivity Pneumonitis: Perspectives in Diagnosis and Management".
[So] Source:Am J Respir Crit Care Med;, 2018 Mar 05.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1164/rccm.201802-0314LE

  9 / 18246 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29505271
[Au] Autor:Fernández Pérez ER
[Ad] Address:National Jewish Health, Pulmonary, Critical Care and Sleep Medicine , Denver, Colorado, United States ; fernandezevans@njhealth.org.
[Ti] Title:Diagnostic Decision Making in Hypersensitivity Pneumonitis: Towards a Consensus Statement.
[So] Source:Am J Respir Crit Care Med;, 2018 Mar 05.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1164/rccm.201711-2358LE

  10 / 18246 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29505269
[Au] Autor:Salisbury ML; Myers JL; Belloli EA; Kazerooni EA; Martinez FJ; Flaherty KR
[Ad] Address:University of Michigan, Pulmonary and Critical Care Medicine, Ann Arbor, Michigan, United States ; mls8b8@gmail.com.
[Ti] Title:Reply from the Authors of "Diagnosis and Treatment of Fibrotic Hypersensitivity Pneumonia. Where We Stand and Where We Need to Go".
[So] Source:Am J Respir Crit Care Med;, 2018 Mar 05.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1164/rccm.201801-0125LE


page 1 of 1825 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information