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[PMID]: 29381243
[Au] Autor:Xu K; Pan X; Qiu X; Wang D; Dong N; Yang L; Li S
[Ad] Address:Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
[Ti] Title:Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling.
[So] Source:Wound Repair Regen;, 2018 Jan 30.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:During tendon injuries, nerve ingrowth is one of the earliest events of tendon repair and remodeling. Since peripheral neurons and associated cells are mostly derived from neural crest (NC) cells, we sought to investigate the role of NC-derived cells in tendon regeneration. Thus, we used Sox10-Cre/ROSA26-Flox-Red Fluorescent Protein (RFP) transgenic mice to trace these cells during tendon regeneration. After 4 weeks of Achilles tendon rupture, the injured tendon tissues were harvested for immunohistological analyses, cell isolation, and phenotype identification. In addition, the tenocytes were co-cultured with RFP labeled cells to examine cellular functions. Following the injury, a significant number of RFP-labeled cells penetrated into the wound site and reached a peak (∼30% of cells) after 2 weeks, and then stabilized at a level of approximately 20%. Interestingly, 36.9% RFP labeled cells in the injured area expressed Tuj1, suggesting that most of the cells are peripheral neurons. Some RFP /Tuj1 cells were also found adjacent to newly formed blood vessels in the tendon. Importantly, the existing neuropeptide Y (NPY) and neuropeptide Y receptor (NPYr) in the ingrowth nerve and blood vessels showed the direct correlation with each other. In addition, there were also RFP cells (∼30%) negative for neuron markers but positive for fibroblast markers, that is, FAP (34.7%) and Vimentin (Vmt) (27.2%), and approximately 10% positive for Sox10. Indeed, many RFP cells isolated from the ruptured Achilles tendon showed long spindle shapes and expressed fibroblast phenotypic markers FSP1 and FAP. Particularly, part of the Sox10 RFP-labeled cells exhibited osteogenic and adipogenic differentiation ability. It is concluded that after Achilles tendon injury, nerves sprout into the wound site. The NC-derived Vmt /FAP mesenchymal cells and peripheral nerves participate in tendon regeneration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/wrr.12614

  2 / 9880 MEDLINE  
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[PMID]: 29395651
[Au] Autor:Kitano T; Yagita Y
[Ad] Address:Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan. Electronic address: takayakitano@neurol.med.osaka-u.ac.jp.
[Ti] Title:In Response to: De Bernardo, M and Rosa, N. "Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy".
[So] Source:J Stroke Cerebrovasc Dis;27(4):1125, 2018 Apr.
[Is] ISSN:1532-8511
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review

  3 / 9880 MEDLINE  
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[PMID]: 29521016
[Au] Autor:Hayata T; Chiga M; Ezura Y; Asashima M; Katabuchi H; Nishinakamura R; Noda M
[Ad] Address:Department of Biological Signaling and Regulation, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
[Ti] Title:Dullard deficiency causes hemorrhage in the adult ovarian follicles.
[So] Source:Genes Cells;, 2018 Mar 09.
[Is] ISSN:1365-2443
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In mammals, the ovarian follicles are regulated at least in part by bone morphogenetic protein (BMP) family members. Dullard (also known as Ctdnep1) gene encodes a phosphatase that suppresses BMP signaling by inactivating or degrading BMP receptors. Here we report that the Col1a1-Cre-induced Dullard mutant mice displayed hemorrhagic ovarian cysts, with red blood cells accumulated in the follicles, resulting in infertility. Cells expressing Cre driven by Col1a1 2.3-kb promoter and their descendants were found in granulosa cells in the ovary and in Sertoli cells in the testis. DullardmRNA was localized to granulosa cells in the ovary. Genes involved in steroid hormone genesis including Cyp11a1, Hsd3b1 and Star were reduced, whereas expression of Smad6 and Smad7, BMP-inducible inhibitory Smads, was up-regulated in the Dullard mutant ovaries. Tamoxifen-inducible Dullard deletion in the whole body using Rosa26-CreER mice also resulted in hemorrhagic ovarian cysts in 2 weeks, which was rescued by administration of LDN-193189, a chemical inhibitor of BMP receptor kinase, suggesting that the hemorrhage in the Dullard-deficient ovarian follicles might be caused by increased BMP signaling. Thus, we conclude that Dullard is essential for ovarian homeostasis at least in part via suppression of BMP signaling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/gtc.12575

  4 / 9880 MEDLINE  
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[PMID]: 29519378
[Au] Autor:Zocca P; Kok MM; Tandjung K; Danse PW; Jessurun GAJ; Hautvast RWM; van Houwelingen KG; Stoel MG; Schramm AR; Tjon Joe Gin RM; de Man FHAF; Hartmann M; Louwerenburg JHW; Linssen GCM; Löwik MM; Doggen CJM; von Birgelen C
[Ad] Address:Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, the Netherlands.
[Ti] Title:5-Year Outcome Following Randomized Treatment of All-Comers With Zotarolimus-Eluting Resolute Integrity and Everolimus-Eluting PROMUS Element Coronary Stents: Final Report of the DUTCH PEERS (TWENTE II) Trial.
[So] Source:JACC Cardiovasc Interv;11(5):462-469, 2018 Mar 12.
[Is] ISSN:1876-7605
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The study sought to evaluate for the first time the 5-year outcomes after treating an all-comers population with newer-generation cobalt chromium-based Resolute Integrity zotarolimus-eluting stents (ZES) (Medtronic, Santa Rosa, California) versus platinum chromium-based PROMUS Element everolimus eluting stents (EES) (Boston Scientific, Natick, Massachusetts). BACKGROUND: The DUTCH PEERS (TWENTE II) (DUrable polymer-based sTent CHallenge of Promus ElemEnt versus ReSolute integrity: TWENTE II) trial is a randomized, multicenter, single-blinded, investigator-initiated all-comers trial that found at its main analysis similar 1-year safety and efficacy for both drug-eluting stents. It is the first randomized trial ever to investigate the Resolute Integrity ZES and the first trial to compare both devices. METHODS: In total, 1,811 patients were 1:1 randomized to ZES versus EES. We performed a pre-specified assessment of the 5-year clinical outcomes in terms of safety and efficacy. The main endpoint target vessel failure (TVF) is a composite of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization. Secondary endpoints included the individual components of TVF, and stent thrombosis. The study was independently monitored, and adverse clinical events were independently adjudicated. RESULTS: Five-year clinical follow-up data was available in 1,798 (99.3%) patients. The ZES and EES groups showed favorable outcomes, with similar 5-year incidence of TVF (13.2% vs. 14.2%; p = 0.62) and its individual components: cardiac death (4.5% vs. 4.9%; p = 0.69), target vessel-related myocardial infarction (3.1% vs. 2.6%; p = 0.47), and target vessel revascularization (7.6% vs. 8.6%; p = 0.46). The 5-year incidence of definite or probable stent thrombosis was similar (1.5% vs. 1.3%; p = 0.83). CONCLUSIONS: At 5-year follow-up, the Resolute Integrity ZES and PROMUS Element EES showed similar and sustained results in terms of safety and efficacy for treating a broad population of all-comers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  5 / 9880 MEDLINE  
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[PMID]: 29494147
[Au] Autor:Li A; Paine MRL; Zambrzycki S; Stryffeler RB; Wu J; Bouza M; Huckaby J; Chang CY; Kumar M; Mukhija P; Fernández FM
[Ad] Address:School of Chemistry and Biochemistry , Georgia Institute of Technology , 901 Atlantic Drive Northwest , Atlanta , Georgia 30332 , United States.
[Ti] Title:Robotic Surface Analysis Mass Spectrometry (RoSA-MS) of Three-Dimensional Objects.
[So] Source:Anal Chem;, 2018 Mar 07.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Many technologies currently exist that are capable of analyzing the surface of solid samples under ambient or vacuum conditions, but they are typically limited to smooth, planar surfaces. Those few that can be applied to nonplanar surfaces, however, require manual sampling and a high degree of human intervention. Herein, we describe a new platform, Robotic Surface Analysis Mass Spectrometry (RoSA-MS), for direct surface sampling of three-dimensional (3D) objects. In RoSA-MS, a sampling probe is attached to a robotic arm that has 360° rotation through 6 individual joints. A 3D laser scanner, also attached to the robotic arm, generates a digital map of the sample surface that is used to direct a probe to specific ( x, y, z) locations. The sampling probe consists of a spring-loaded needle that briefly contacts the object surface, collecting trace amounts of material. The probe is then directed at an open port liquid sampling interface coupled to the electrospray ion source of a mass spectrometer. Material on the probe tip is dissolved by the solvent flow in the liquid interface and mass analyzed with high mass resolution and accuracy. The surface of bulky, nonplanar objects can thus be probed to produce chemical maps at the molecular level. Applications demonstrated herein include the examination of food sample surfaces, lifestyle chemistry, and chemical reactions on curved substrates. The modular design of this system also allows for modifications to the sampling probe and the ionization source, thereby expanding the potential of RoSA-MS for a great diversity of applications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1021/acs.analchem.7b04980

  6 / 9880 MEDLINE  
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[PMID]: 29513319
[Au] Autor:Liu X; Gao Y; Li D; Liu C; Jin M; Bian J; Lv M; Sun Y; Zhang L; Gao P
[Ad] Address:Institute of Functional Molecules, College of Pharmaceutical and Biotechnology Engineering, Shenyang University of Chemical Technology, Shenyang 110142, People's Republic of China. gpy1981@163.com.
[Ti] Title:The neuroprotective and antioxidant profiles of selenium-containing polysaccharides from the fruit of Rosa laevigata.
[So] Source:Food Funct;, 2018 Mar 07.
[Is] ISSN:2042-650X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Rosa laevigata fruit has been known as a functional foodstuff for a long time. Recently, increasing attention has been given to polysaccharides from R. laevigata fruit due to their numerous medicinal and nutritional properties. In this study, a rapid and effective approach for the extraction and separation of polysaccharides from the title fruit was developed using microwave-assisted aqueous two-phase extraction (MA-ATPE) with a PEG/ammonium sulfate system. After analysis of the response surface methodology (RSM) data based on a Box-Behnken design (BBD), a model was proposed and was found to predict an optimum yield value of 258.99 mg g which is in good agreement with the experimental value (258.59 mg g ). Two selenium (Se)-containing polysaccharides, Se-RLFP-1 and Se-RLFP-2, were isolated from R. laevigata fruit. Their chemical structures were elucidated by acid hydrolysis, weight-average molecular mass and Se-content analysis, along with UV, FT-IR, H and C NMR spectroscopy. As a result, Se-RLFP-1 was found to be mainly composed of mannose, glucose, galactose and xylose in a molar ratio of 1.4 : 7.9 : 1.0 : 1.5, while Se-RLFP-2 was composed of mannose, rhamnose, glucose, galactose and xylose (12.6 : 1.0 : 38.3 : 5.6 : 19.6). Furthermore, the antioxidant properties of the polysaccharides were investigated on the basis of FRAP, ABTS and DPPH radical scavenging assays. The results showed that the two polysaccharides had a noticeable effect on the radical scavenging of ABTS and DPPH, especially at high concentrations. In addition, the neuroprotective effect of Se-RLFP-1 and Se-RLFP-2 against oxidative stress induced by H O in SH-SY5Y neuroblastoma cells was also investigated. In particular, Se-RLFP-1 exhibited obvious neuroprotective activity at a concentration of 100 µg mL .
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1039/c7fo01725a

  7 / 9880 MEDLINE  
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[PMID]: 29511789
[Au] Autor:Olchowy C; de Albert M; Perez M; Ciriaco N; Dominguez Oronoz R
[Ad] Address:Department of Radiology, Medical University of Wroclaw, M. Curie-Sklodowskiej 68, 50-369, Wroclaw, Poland. cyprian.olchowy@gmail.com.
[Ti] Title:Correction to: Triple elastofibromas located in the supra- and infrascapular regions-a case report.
[So] Source:Skeletal Radiol;, 2018 Mar 07.
[Is] ISSN:1432-2161
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The original version of this article unfortunately contained mistakes. The authornames of Matías de Albert, Manuel Perez, and Rosa Dominguez Oronoz as well as the affiliation of Dr. Perez are now corrected in this article.
[Pt] Publication type:PUBLISHED ERRATUM
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1007/s00256-018-2925-5

  8 / 9880 MEDLINE  
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[PMID]: 29509881
[Au] Autor:Whittington HJ; Ostrowski PJ; McAndrew DJ; Cao F; Shaw A; Eykyn TR; Lake H; Tyler J; Schneider JE; Neubauer S; Zervou S; Lygate CA
[Ad] Address:Division of Cardiovascular Medicine, Radcliffe Department of Medicine, and the BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
[Ti] Title:Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.
[So] Source:Cardiovasc Res;, 2018 Mar 02.
[Is] ISSN:1755-3245
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Aims: Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesised that elevating MtCK would be beneficial in ischaemia-reperfusion (I/R) injury. Methods and Results: Mice were created overexpressing the sarcomeric MtCK gene with αMHC promoter at the Rosa26 locus (MtCK-OE) and compared with wild-type (WT) littermates. MtCK activity was 27% higher than WT, with no change in other CK isoenzymes or creatine levels. Electron microscopy confirmed normal mitochondrial cell density and mitochondrial localisation of transgenic protein. Respiration in isolated mitochondria was unaltered and metabolomic analysis by 1H-NMR suggests that cellular metabolism was not grossly affected by transgene expression. There were no significant differences in cardiac structure or function under baseline conditions by cine-MRI or LV haemodynamics. In Langendorff-perfused hearts subjected to 20min ischaemia and 30 min reperfusion, MtCK-OE exhibited less ischaemic contracture and improved functional recovery (Rate pressure product 58% above WT; P < 0.001). These hearts had reduced myocardial infarct size, which was confirmed in vivo: 55±4% in WT vs 29±4% in MtCK-OE; P < 0.0001). Isolated cardiomyocytes from MtCK-OE hearts exhibited delayed opening of the mitochondrial permeability transition pore (mPTP) compared to WT, which was confirmed by reduced mitochondrial swelling in response to calcium. There was no detectable change in the structural integrity of the mitochondrial membrane. Conclusions: Modest elevation of MtCK activity in the heart does not adversely affect cellular metabolism, mitochondrial or in vivo cardiac function, but modifies mPTP opening to protect against I/R injury and improve functional recovery. Our findings support MtCK as a prime therapeutic target in myocardial ischaemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1093/cvr/cvy054

  9 / 9880 MEDLINE  
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[PMID]: 29194513
[Au] Autor:Ramirez PG; Stein M; Etchepare EG; Almirón WR
[Ad] Address:Instituto de Medicina Regional, Universidad Nacional del Nordeste, Avenida Las Heras, Resistencia, Chaco, Argentina.
[Ti] Title:Composition of Anopheline (Diptera: Culicidae) Community and Its Seasonal Variation in Three Environments of the City of Puerto Iguazú, Misiones, Argentina.
[So] Source:J Med Entomol;55(2):351-359, 2018 Feb 28.
[Is] ISSN:1938-2928
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In order to extend the knowledge of the composition of the anopheline community and the seasonal variation related to anthropogenic modifications in the city of Puerto Iguazú, adult females were captured between 2009 and 2012. Samples were collected in three environments with different degrees of anthropogenic modification: urban, periurban, and wild. Alpha diversity was evaluated as the 'true' diversity of the species in each environment. Among environments, range-abundance curves were used to compare the composition, abundance, and uniformity of species and cluster analysis was used to analyze the similarities and differences. The temporal distribution was analyzed and the relative abundance of the species captured was correlated with meteorological variables. A total of 4,565 females, belonging to seven species: Anopheles albitarsis s.s. (Lynch-Arribálzaga), Anopheles argyritarsis (Robineau-Desvoidy), Anopheles deaneorum (Rosa-Freitas), Anopheles fluminensis (Root), Anopheles mediopunctatus (Theobald), Anopheles strodei s.l. (Root), and Anopheles triannulatus s.l. (Neiva and Pinto) were captured. The wild environment showed higher abundance, diversity, and greater uniformity reflected on the less sharp area of the range-abundance curve. Species richness was the same in the wild and periurban environments. Higher abundances were observed in summer during the months with higher temperatures. Although the wild environment showed greater Anopheles abundances and diversity, specific richness and species complementarity were similar among the three environments studied. Thus, the periurban environment would turn into a transition zone of great epidemiological importance due to the introduction of people in this environment, which represents a potential risk of malaria transmission in the area.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review
[do] DOI:10.1093/jme/tjx215

  10 / 9880 MEDLINE  
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[PMID]: 29316270
[Au] Autor:Spyrantis A; Cattani A; Strzelczyk A; Rosenow F; Seifert V; Freiman TM
[Ad] Address:Neurosurgery, Goethe-Universitat Frankfurt am Main, Germany.
[Ti] Title:Robot-guided stereoelectroencephalography without a computed tomography scan for referencing: Analysis of accuracy.
[So] Source:Int J Med Robot;14(2), 2018 Apr.
[Is] ISSN:1478-596X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Recent studies with robot-guided stereotaxy use computed tomography (CT) scans for referencing. We will provide evidence that using preoperative MRI datasets referenced with a laser scan of the patient's face is sufficient for sEEG implantation. METHODS: In total, 40 sEEG electrodes were implanted in five patients by the robotic surgical assistant (ROSA). The postoperative CT scan for identifying electrode positions was fused with the preoperative MRI-based planning data. The accuracy was determined by the target point error (TPE) and the entry point error (EPE), applying the Euclidean distance. RESULTS: The mean TPE amounted to 2.96 mm, the mean EPE to 2.53 mm. The accuracy was improved in 1.5 T MRI: the mean TPE amounted to 1.72 mm, the EPE to 0.97 mm. No complications, haemorrhages, infections, etc., were observed. CONCLUSIONS: Robot-guided sEEG based on 3 T MRI reduces radiation exposure for the patient and can still be performed safely.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1002/rcs.1888


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