Database : MEDLINE
Search on : Rubulavirus and Infections [Words]
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[PMID]: 28185101
[Au] Autor:Garcia-Barrera AA; Del Valle A; Montaño-Hirose JA; Barrón BL; Salinas-Trujano J; Torres-Flores J
[Ad] Address:Laboratorio de Virología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Casco de Santo Tomás, 11340, Mexico City, Mexico.
[Ti] Title:Full-genome sequencing and phylogenetic analysis of four neurovirulent Mexican isolates of porcine rubulavirus.
[So] Source:Arch Virol;162(6):1765-1768, 2017 Jun.
[Is] ISSN:1432-8798
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:We report the complete genome sequences of four neurovirulent isolates of porcine rubulavirus (PorPV) from 2015 and one historical PorPV isolate from 1984 obtained by next-generation sequencing. A phylogenetic tree constructed using the individual sequences of the complete HN genes of the 2015 isolates and other historical sequences deposited in the GenBank database revealed that several recent neurovirulent isolates of PorPV (2008-2015) cluster together in a separate clade. Phylogenetic analysis of the complete genome sequences revealed that the neurovirulent strains of PorPV that circulated in Mexico during 2015 are genetically different from the PorPV strains that circulated during the 1980s.
[Mh] MeSH terms primary: Genome, Viral
Phylogeny
Rubulavirus Infections/veterinary
Rubulavirus/isolation & purification
Swine Diseases/virology
[Mh] MeSH terms secundary: Animals
Base Sequence
Mexico
Molecular Sequence Data
RNA, Viral/genetics
Rubulavirus/classification
Rubulavirus/genetics
Rubulavirus Infections/virology
Swine
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (RNA, Viral)
[Em] Entry month:1706
[Cu] Class update date: 170630
[Lr] Last revision date:170630
[Js] Journal subset:IM
[Da] Date of entry for processing:170211
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3267-7

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[PMID]: 28138777
[Au] Autor:Zhai JQ; Zhai SL; Lin T; Liu JK; Wang HX; Li B; Zhang H; Zou SZ; Zhou X; Wu MF; Chen W; Luo ML
[Ad] Address:Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
[Ti] Title:First complete genome sequence of parainfluenza virus 5 isolated from lesser panda.
[So] Source:Arch Virol;162(5):1413-1418, 2017 May.
[Is] ISSN:1432-8798
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:Parainfluenza virus 5 (PIV5) is widespread in mammals and humans. Up to now, there is little information about PIV5 infection in lesser pandas. In this study, a PIV5 variant (named ZJQ-221) was isolated from a lesser panda with respiratory disease in Guangzhou zoo in Guangdong province, southern China. The full-length genome of ZJQ-221 was found to be 15,246 nucleotides and consisted of seven non-overlapping genes encoding eight proteins (i.e., NP, V, P, M, F, SH, HN and L). Sequence alignment and genetic analysis revealed that ZJQ-221 shared a close relationship with a PIV5 strain of canine-origin (1168-1) from South Korea. The findings of this study confirm the presence of PIV5 in lesser panda and indicate this mammal as a possible natural reservoir. Furthermore they highlight the urgent need to strengthen viral surveillance and control of PIV5 in zoo animals.
[Mh] MeSH terms primary: Ailuridae/virology
DNA, Viral/genetics
Genome, Viral/genetics
Parainfluenza Virus 5/genetics
Rubulavirus Infections/veterinary
[Mh] MeSH terms secundary: Animals
Animals, Zoo/virology
Base Sequence
Cell Line
Cercopithecus aethiops
Parainfluenza Virus 5/isolation & purification
Rubulavirus Infections/virology
Sequence Analysis, DNA
Vero Cells
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Viral)
[Em] Entry month:1704
[Cu] Class update date: 170428
[Lr] Last revision date:170428
[Js] Journal subset:IM
[Da] Date of entry for processing:170201
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3245-0

  3 / 149 MEDLINE  
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[PMID]: 28102432
[Au] Autor:Bulavaite A; Lasickiene R; Tamosiunas PL; Simanavicius M; Sasnauskas K; Zvirbliene A
[Ad] Address:Institute of Biotechnology, Vilnius University, Sauletekio 7, LT-10257, Vilnius, Lithuania. aiste.bulavaite@bti.vu.lt.
[Ti] Title:Synthesis of human parainfluenza virus 4 nucleocapsid-like particles in yeast and their use for detection of virus-specific antibodies in human serum.
[So] Source:Appl Microbiol Biotechnol;101(7):2991-3004, 2017 Apr.
[Is] ISSN:1432-0614
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The aim of this study was to produce human parainfluenza virus type 4 (HPIV4) nucleocapsid (N) protein in yeast Saccharomyces cerevisiae expression system, to explore its structural and antigenic properties and to evaluate its applicability in serology. The use of an optimized gene encoding HPIV4 N protein amino acid (aa) sequence GenBank AGU90031.1 allowed high yield of recombinant N protein forming nucleocapsid-like particles (NLPs) in yeast. A substitution L332D disrupted self-assembly of NLPs, confirming the role of this position in the N proteins of Paramyxovirinae. Three monoclonal antibodies (MAbs) were generated against the NLP-forming HPIV4 N protein. They recognised HPIV4-infected cells, demonstrating the antigenic similarity between the recombinant and virus-derived N proteins. HPIV4 N protein was used as a coating antigen in an indirect IgG ELISA with serum specimens of 154 patients with respiratory tract infection. The same serum specimens were tested with previously generated N protein of a closely related HPIV2, another representative of genus Rubulavirus. Competitive ELISA was developed using related yeast-produced viral antigens to deplete the cross-reactive serum antibodies. In the ELISA either without or with competition using heterologous HPIV (2 or 4) N or mumps virus N proteins, the seroprevalence of HPIV4 N-specific IgG was, respectively, 46.8, 39.6 and 40.3% and the seroprevalence of HPIV2 N-specific IgG-47.4, 39.0 and 37.7%. In conclusion, yeast-produced HPIV4 N protein shares structural and antigenic properties of the native virus nucleocapsids. Yeast-produced HPIV4 and HPIV2 NLPs are prospective tools in serology.
[Mh] MeSH terms primary: Antibodies, Viral/blood
Immunoglobulin G/blood
Nucleocapsid Proteins/immunology
Parainfluenza Virus 4, Human/immunology
Respiratory Tract Infections/immunology
Rubulavirus Infections/immunology
Saccharomyces cerevisiae/genetics
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Antibodies, Monoclonal/immunology
Antigens, Viral/immunology
Child
Child, Preschool
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Nucleocapsid
Nucleocapsid Proteins/blood
Nucleocapsid Proteins/genetics
Parainfluenza Virus 2, Human/chemistry
Parainfluenza Virus 2, Human/genetics
Parainfluenza Virus 2, Human/immunology
Parainfluenza Virus 4, Human/chemistry
Parainfluenza Virus 4, Human/genetics
Prospective Studies
Recombinant Proteins/immunology
Respiratory Tract Infections/virology
Saccharomyces cerevisiae/metabolism
Seroepidemiologic Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Monoclonal); 0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Immunoglobulin G); 0 (Nucleocapsid Proteins); 0 (Recombinant Proteins)
[Em] Entry month:1704
[Cu] Class update date: 170405
[Lr] Last revision date:170405
[Js] Journal subset:IM
[Da] Date of entry for processing:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-017-8104-0

  4 / 149 MEDLINE  
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[PMID]: 27996140
[Au] Autor:Woo SH; Park J
[Ad] Address:Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.
[Ti] Title:Image Gallery: A case of unilateral laterothoracic exanthem.
[So] Source:Br J Dermatol;175(6):e151, 2016 Dec.
[Is] ISSN:1365-2133
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Erythema/virology
Parainfluenza Virus 2, Human
Rubulavirus Infections/pathology
[Mh] MeSH terms secundary: Axilla
Child, Preschool
Erythema/pathology
Humans
Male
Musculoskeletal Pain/virology
Shoulder
Thorax
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171002
[Lr] Last revision date:171002
[Js] Journal subset:IM
[Da] Date of entry for processing:161221
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15041

  5 / 149 MEDLINE  
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[PMID]: 27619056
[Au] Autor:Yadav P; Sarkale P; Patil D; Shete A; Kokate P; Kumar V; Jain R; Jadhav S; Basu A; Pawar S; Sudeep A; Gokhale M; Lakra R; Mourya D
[Ad] Address:National Institute of Virology, Pune, 20-A, Dr. Ambedkar Road, Pune, Maharashtra Pin 411001, India.
[Ti] Title:Isolation of Tioman virus from Pteropus giganteus bat in North-East region of India.
[So] Source:Infect Genet Evol;45:224-229, 2016 Nov.
[Is] ISSN:1567-7257
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Bat-borne viral diseases are a major public health concern among newly emerging infectious diseases which includes severe acute respiratory syndrome, Nipah, Marburg and Ebola virus disease. During the survey for Nipah virus among bats at North-East region of India; Tioman virus (TioV), a new member of the Paramyxoviridae family was isolated from tissues of Pteropus giganteus bats for the first time in India. This isolate was identified and confirmed by RT-PCR, sequence analysis and electron microscopy. A range of vertebrate cell lines were shown to be susceptible to Tioman virus. Negative electron microscopy study revealed the "herringbone" morphology of the nucleocapsid filaments and enveloped particles with distinct envelope projections a characteristic of the Paramyxoviridae family. Sequence analysis of Nucleocapsid gene of TioV demonstrated sequence identity of 99.87% and 99.99% nucleotide and amino acid respectively with of TioV strain isolated in Malaysia, 2001. This report demonstrates the first isolation of Tioman virus from a region where Nipah virus activity has been noticed in the past and recent years. Bat-borne viruses have become serious concern world-wide. A Survey of bats for novel viruses in this region would help in recognizing emerging viruses and combating diseases caused by them.
[Mh] MeSH terms primary: Chiroptera/virology
Rubulavirus Infections
Rubulavirus
[Mh] MeSH terms secundary: Animals
Cell Line
Chick Embryo
India
Rubulavirus/classification
Rubulavirus/genetics
Rubulavirus/isolation & purification
Rubulavirus Infections/veterinary
Rubulavirus Infections/virology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[Js] Journal subset:IM
[Da] Date of entry for processing:160914
[St] Status:MEDLINE

  6 / 149 MEDLINE  
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[PMID]: 27505156
[Au] Autor:Li Y; Johnson JB; Parks GD
[Ad] Address:Burnett School of Biomedical Sciences, University of Central Florida, College of Medicine, Orlando, FL 32827, USA.
[Ti] Title:Parainfluenza virus 5 upregulates CD55 expression to produce virions with enhanced resistance to complement-mediated neutralization.
[So] Source:Virology;497:305-313, 2016 Oct.
[Is] ISSN:1096-0341
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Many enveloped RNA viruses recruit host cell proteins during assembly as a mechanism to limit antiviral effects of complement. Using viruses which incorporated CD46 alone, CD55 alone or both CD46 and CD55, we addressed the role of these two host cell regulators in limiting complement-mediated neutralization of Parainfluenza virus 5 (PIV5). PIV5 incorporated functional forms of both CD55 and CD46 into virions. PIV5 containing CD55 was highly resistant to complement-mediated neutralization, whereas CD46-containing PIV5 was as sensitive to neutralization as virus lacking both regulators. PIV5 infected cells had increased levels of cell surface CD55, which was further upregulated by exogenous treatment with tumor necrosis factor alpha. PIV5 derived from cells with higher CD55 levels was more resistant to complement-mediated neutralization in vitro than virus from control cells. We propose a role for virus induction of host cell complement inhibitors in defining virus growth and tissue tropism.
[Mh] MeSH terms primary: CD55 Antigens/genetics
Complement System Proteins/immunology
Gene Expression Regulation
Parainfluenza Virus 5/physiology
Rubulavirus Infections/genetics
Rubulavirus Infections/virology
Virus Replication
[Mh] MeSH terms secundary: Animals
CD55 Antigens/metabolism
CHO Cells
Cell Line
Complement Activation/immunology
Cricetinae
Cricetulus
Humans
Membrane Cofactor Protein/genetics
Membrane Cofactor Protein/metabolism
Neutralization Tests
Rubulavirus Infections/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (CD55 Antigens); 0 (Membrane Cofactor Protein); 9007-36-7 (Complement System Proteins)
[Em] Entry month:1705
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:160810
[St] Status:MEDLINE

  7 / 149 MEDLINE  
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[PMID]: 27197630
[Au] Autor:Xiao NG; Duan ZJ; Xie ZP; Zhong LL; Zeng SZ; Huang H; Gao HC; Zhang B
[Ad] Address:Department of Pediatrics, Hunan Provincial People's Hospital, Hunan Provincial, China.
[Ti] Title:Human parainfluenza virus types 1-4 in hospitalized children with acute lower respiratory infections in China.
[So] Source:J Med Virol;88(12):2085-2091, 2016 Dec.
[Is] ISSN:1096-9071
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human parainfluenza viruses (HPIVs) are an important cause of acute lower respiratory tract infections (ALRTIs). HPIV-4, a newly identified virus, has been associated with severe ALRTIs recently. A total of 771 nasopharyngeal aspirate samples were collected from hospitalized children between March 2010 and February 2011. HPIVs were detected by Nest-PCR, and other known respiratory viruses were detected by RT-PCR and PCR. All amplification products were sequenced. HPIVs were detected in 151 (19.58%) patients, of whom 28 (3.63%) were positive for HPIV-4, 12(1.55%) for HPIV-1, 4 (0.51%) for HPIV-2, and 107 (13.87%) for HPIV-3. Only three were found to be co-infected with different types of HPIVs. All HPIV-positive children were under 5 years of age, with the majority being less than 1 year. Only the detection rate of HPIV-3 had a significant statistical difference (χ = 29.648, P = 0.000) between ages. HPIV-3 and HPIV-4 were detected during the summer. Sixty (39.74%) were co-infected with other respiratory viruses, and human rhinovirus (HRV) was the most common co-infecting virus. The most frequent clinical diagnosis was bronchopneumonia, and all patients had cough; some patients who were infected with HPIV-3 and HPIV-4 had polypnea and cyanosis. No significant difference was found in clinical manifestations between those who were infected with HPIV-4 and HPIV-3. Two genotypes for HPIV-4 were prevalent, although HPIV-4a dominated. HPIV-4 is an important virus for children hospitalized with ALRTIs in China. HRV was the most common co-infecting virus. Two genotypes for HPIV-4 are prevalent, HPIV-4a dominated. J. Med. Virol. 88:2085-2091, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] MeSH terms primary: Parainfluenza Virus 1, Human/isolation & purification
Parainfluenza Virus 2, Human/isolation & purification
Parainfluenza Virus 3, Human/isolation & purification
Parainfluenza Virus 4, Human/isolation & purification
Respiratory Tract Infections/epidemiology
Respirovirus Infections/epidemiology
Rubulavirus Infections/epidemiology
[Mh] MeSH terms secundary: Acute Disease/epidemiology
Adolescent
Child
Child, Preschool
China/epidemiology
Coinfection/virology
Female
Genotype
Hospitalization
Humans
Infant
Male
Pneumonia/epidemiology
Pneumonia/virology
Prevalence
Respiratory Tract Infections/virology
Respirovirus Infections/virology
Rubulavirus Infections/virology
Seasons
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170807
[Lr] Last revision date:170807
[Js] Journal subset:IM
[Da] Date of entry for processing:160521
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24580

  8 / 149 MEDLINE  
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[PMID]: 27004845
[Au] Autor:Santak M; Slovic A; Ljubin-Sternak S; Mlinaric Galinovic G; Forcic D
[Ad] Address:Centre for Research and Knowledge Transfer in Biotechnology, University of Zagreb, Zagreb, Croatia.
[Ti] Title:Genetic diversity among human parainfluenza virus type 2 isolated in Croatia between 2011 and 2014.
[So] Source:J Med Virol;88(10):1733-41, 2016 Oct.
[Is] ISSN:1096-9071
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The dynamics and evolution of the human parainfluenza virus type 2 (HPIV2) in Croatia, and also globally, are largely unknown. Most HPIV2 infections are treated symptomatically outside the hospital setting. Thus, the diagnosis is missing making it difficult to follow the genetic variation and evolution of the HPIV2. This study explores hospitalized HPIV2 cases in Croatia during 4-year period (2011-2014). Most cases in this period were reported in October or November (68.75%) and most of patients were under 2 years of age (81.25%). For molecular analyses, we used the F and HN gene sequences and showed that although both regions are equally suitable for phylogenetic analyses it would be advantageous to use regions longer than 2 kb for HPIV2 analyses of isolates which are spatially and temporally closely related. We show here that the dominant cluster in this area was cluster G3 while only one strain isolated in this period was positioned in the distant cluster G1a. Further monitoring of the HPIV2 will determine whether cluster G3 will remain dominant or it will be overruled by cluster G1a. This will be important for the surveillance of virus circulation in population and significance of the viral infection. J. Med. Virol. 88:1733-1741, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] MeSH terms primary: Genetic Variation
Parainfluenza Virus 2, Human/genetics
Rubulavirus Infections/virology
[Mh] MeSH terms secundary: Animals
Cercopithecus aethiops
Child
Child, Preschool
Croatia/epidemiology
Female
HN Protein/genetics
Hospitalization
Humans
Infant
Male
Parainfluenza Virus 2, Human/classification
Parainfluenza Virus 2, Human/isolation & purification
Phylogeny
Rubulavirus Infections/epidemiology
Vero Cells
Viral Fusion Proteins/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (HN Protein); 0 (Viral Fusion Proteins)
[Em] Entry month:1707
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[Js] Journal subset:IM
[Da] Date of entry for processing:160324
[St] Status:MEDLINE
[do] DOI:10.1002/jmv.24532

  9 / 149 MEDLINE  
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[PMID]: 26854342
[Au] Autor:Rivera-Benitez JF; De la Luz-Armendáriz J; Saavedra-Montañez M; Jasso-Escutia MÁ; Sánchez-Betancourt I; Pérez-Torres A; Reyes-Leyva J; Hernández J; Martínez-Lara A; Ramírez-Mendoza H
[Ad] Address:Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Distrito Federal, Mexico; Centro Nacional de Investigación Disciplinaria en Microbiología Animal, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuaria
[Ti] Title:Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus.
[So] Source:Vet Microbiol;184:31-9, 2016 Feb 29.
[Is] ISSN:1873-2542
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Porcine rubulavirus (PorPV) and swine influenza virus infection causes respiratory disease in pigs. PorPV persistent infection could facilitate the establishment of secondary infections. The aim of this study was to analyse the pathogenicity of classic swine H1N1 influenza virus (swH1N1) in growing pigs persistently infected with porcine rubulavirus. Conventional six-week-old pigs were intranasally inoculated with PorPV, swH1N1, or PorPV/swH1N1. A mock-infected group was included. The co-infection with swH1N1 was at 44 days post-infection (DPI), right after clinical signs of PorPV infection had stopped. The pigs of the co-infection group presented an increase of clinical signs compared to the simple infection groups. In all infected groups, the most recurrent lung lesion was hyperplasia of the bronchiolar-associated lymphoid tissue and interstitial pneumonia. By means of immunohistochemical evaluation it was possible to demonstrate the presence of the two viral agents infecting simultaneously the bronchiolar epithelium. Viral excretion of PorPV in nasal and oral fluid was recorded at 28 and 52 DPI, respectively. PorPV persisted in several samples from respiratory tissues (RT), secondary lymphoid organs (SLO), and bronchoalveolar lavage fluid (BALF). For swH1N1, the viral excretion in nasal fluids was significantly higher in single-infected swH1N1 pigs than in the co-infected group. However, the co-infection group exhibited an increase in the presence of swH1N1 in RT, SLO, and BALF at two days after co-infection. In conclusion, the results obtained confirm an increase in the clinical signs of infection, and PorPV was observed to impact the spread of swH1N1 in analysed tissues in the early stage of co-infection, although viral shedding was not enhanced. In the present study, the interaction of swH1N1 infection is demonstrated in pigs persistently infected with PorPV.
[Mh] MeSH terms primary: Coinfection/pathology
Influenza A Virus, H1N1 Subtype/pathogenicity
Orthomyxoviridae Infections/veterinary
Rubulavirus Infections/veterinary
Swine Diseases/virology
[Mh] MeSH terms secundary: Animals
Antibodies, Viral/blood
Influenza A Virus, H1N1 Subtype/isolation & purification
Orthomyxoviridae Infections/complications
Orthomyxoviridae Infections/pathology
Orthomyxoviridae Infections/virology
Rubulavirus/isolation & purification
Rubulavirus/physiology
Rubulavirus Infections/complications
Rubulavirus Infections/pathology
Rubulavirus Infections/virology
Swine
Swine Diseases/pathology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antibodies, Viral)
[Em] Entry month:1610
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:160209
[St] Status:MEDLINE

  10 / 149 MEDLINE  
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[PMID]: 26728078
[Au] Autor:Cuevas-Romero S; Rivera-Benítez JF; Blomström AL; Ramliden M; Hernández-Baumgarten E; Hernández-Jáuregui P; Ramírez-Mendoza H; Berg M
[Ad] Address:Centro Nacional de Investigación Disciplinaria en Microbiología Animal, INIFAP, Mexico City, Mexico. cuevas.julieta@inifap.gob.mx.
[Ti] Title:Molecular characterisation of Porcine rubulavirus (PorPV) isolates from different outbreaks in Mexico.
[So] Source:Virus Genes;52(1):81-90, 2016 Feb.
[Is] ISSN:1572-994X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Since the report of the initial outbreak of Porcine rubulavirus (PorPV) infection in pigs, only one full-length genome from 1984 (PorPV-LPMV/1984) has been characterised. To investigate the overall genetic variation, full-length gene nucleotide sequences of current PorPV isolates were obtained from different clinical cases of infected swine. Genome organisation and sequence analysis of the encoded proteins (NP, P, F, M, HN and L) revealed high sequence conservation of the NP protein and the expression of the P and V proteins in all PorPV isolates. The V protein of one isolate displayed a mutation that has been implicated to antagonise the antiviral immune responses of the host. The M protein indicated a variation in a short region that could affect the electrostatic charge and the interaction with the membrane. One PorPV isolate recovered from the lungs showed a mutation at the cleavage site (HRKKR) of the F protein that could represent an important factor to determine the tissue tropism and pathogenicity of this virus. The HN protein showed high sequence identity through the years (up to 2013). Additionally, a number of sequence motifs of very high amino acid conservation among the PorPV isolates important for polymerase activity of the L protein have been identified. In summary, genetic comparisons and phylogenetic analyses indicated that three different genetic variants of PorPV are currently spreading within the swine population, and a new generation of circulating virus with different characteristics has begun to emerge.
[Mh] MeSH terms primary: Rubulavirus Infections/veterinary
Rubulavirus/genetics
Swine Diseases/virology
[Mh] MeSH terms secundary: Animals
DNA, Complementary
Disease Outbreaks/veterinary
Genes, Viral
Genetic Variation
Mexico/epidemiology
Phylogeny
RNA, Viral
Rubulavirus/classification
Rubulavirus Infections/epidemiology
Rubulavirus Infections/virology
Sequence Analysis, RNA
Swine
Swine Diseases/epidemiology
Viral Proteins/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (DNA, Complementary); 0 (RNA, Viral); 0 (Viral Proteins)
[Em] Entry month:1610
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:160106
[St] Status:MEDLINE
[do] DOI:10.1007/s11262-015-1281-y


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