Database : MEDLINE
Search on : Rupture [Words]
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[PMID]: 29524719
[Au] Autor:Lv N; Tang H; Chen S; Wang X; Fang Y; Karmonik C; Huang Q; Liu J
[Ad] Address:Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
[Ti] Title:Morphological Parameters Related to Aneurysmal Wall Enhancement in Patients with Multiple Intracranial Aneurysms.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Vessel wall magnetic resonance imaging (MRI) has been suggested as a potential in vivo method to detect inflammation of aneurysm wall and identify unruptured intracranial aneurysm (UIA) with high rupture risk. This study aims to investigate the correlation between aneurysm wall enhancement (AWE) on vessel wall MRI and rupture-related morphological parameters in patients with multiple UIAs. METHODS: Clinical data and VW-MRI images were reviewed in 14 patients with 30 multiple UIAs. The AWE was defined as enhancement of the aneurysm wall in post-contrast vessel wall images using the pre-contrast image as reference. Morphological parameters, including aneurysm size, aspect ratio (AR), size ratio (SR), bottleneck factor (BNF), height-to-width ratio (HW), nonsphericity index (NSI) and inflow angle (IFA) were measured using 3-dimensional rotation angiography. Univariate and multivariate analysis were performed to reveal the correlation between morphological parameters and the presence of AWE. RESULTS: Sixteen of the 30 multiple UIAs presented with AWE on vessel wall MRI images. UIAs with AWE were proven to have a significantly larger size (P=0.001), AR (P=0.047), SR (P=0.003), BNF (P=0.007) and NSI (P=0.007) in univariate analysis. Further multivariate logistic regression showed that aneurysm size [odds ratio (OR)=3.54; 95% confidence interval (CI)=1.10-11.35; P=0.033] and NSI (OR=3.53; 95% CI=1.06-11.80; P=0.040) were independently associated with the presence of AWE in multiple UIAs. CONCLUSION: The presence of AWE on vessel wall MRI was significantly correlated with conventional morphological rupture risk factors in patients with multiple UIAs, which might indicate AWE as a potential radiological predictor for UIAs with high rupture risk.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524462
[Au] Autor:Tigkiropoulos K; Sigala F; Tsilimigras DI; Moris D; Filis K; Melas N; Karamanos D; Kontogiannis C; Lazaridis I; Saratzis N
[Ad] Address:1(st) Department of Surgery, Aristotle University Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
[Ti] Title:Endovascular Repair of Blunt Thoracic Aortic Trauma: Is Post-Implant Hypertension an Incidental Finding?
[So] Source:Ann Vasc Surg;, 2018 Mar 07.
[Is] ISSN:1615-5947
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Blunt thoracic aortic injury (BTAI) is the second most common cause of death in trauma patients. Nowadays, thoracic endovascular aortic repair (TEVAR) has become the treatment of choice due to lower rates of mortality, paraplegia and stroke. However, concerns have been raised whether graft implantation is related to the development of hypertension in the postoperative period. OBJECTIVES: To report short- and long-term outcomes of patients undergoing TEVAR for BTAIs at a tertiary hospital as well as investigate post-implant hypertension. MATERIALS & METHODS: Between January 2005 and January 2016, 23 patients with blunt thoracic aortic trauma underwent TEVAR. Median age was 44 years (range 18-73). Among them, 14 (60.9%) patients were diagnosed with aortic rupture, while 9 (39.1%) with pseudoaneurysm. Α single thoracic stent graft was deployed in 21 patients and the rest 2 patients received two stent grafts. RESULTS: Complete exclusion of the injury was feasible in all subjects (100% primary success). The left subclavian artery (SCA) was intentionally covered in 6 patients (26%). Intraoperative complications included one nonfatal stroke managed conservatively and one external iliac artery rupture, treated with iliofemoral bypass. One patient (4.3%) died on the first postoperative day in the intensive care unit (ICU) due to hemorrhagic shock. The overall 30-day mortality and morbidity were 4.3% and 8.7%, respectively. New-onset post-implantation arterial hypertension was observed in 8 (34.8%) previously non-hypertensive patients. Younger age (p=0.027) and SCA coverage (p=0.01) were identified as potential risk factors for the development of post-implant hypertension, whereas the presence of concomitant injuries (p=0.3) and intraoperative complications (p=0.1) were not. Following a median follow-up of 100 months (range, 18-120), six of them still remain on antihypertensive therapy, whereas the other 2 did not require permanent treatment. CONCLUSIONS: TEVAR is a safe approach in the treatment of BTAI associated with low short- and long-term morbidity and mortality rates. Lower age and SCA coverage may contribute to the development of post-implant hypertension. Further larger cohort studies are warranted in order to elucidate the underlying mechanisms of post-implant hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524354
[Au] Autor:Wu J; Tian X; Liu B; Li C; Hao C
[Ad] Address:Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing, China (mainland).
[Ti] Title:Features and Treatment of Peritoneal Metastases from Solid Pseudopapillary Neoplasms of the Pancreas.
[So] Source:Med Sci Monit;24:1449-1456, 2018 Mar 10.
[Is] ISSN:1643-3750
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND Solid pseudopapillary neoplasms (SPNs) of the pancreas may present widespread peritoneal metastases, but the treatment of this malignancy has not been well described and requires further investigation. MATERIAL AND METHODS Four cases of SPN with significant peritoneal metastases in our department were operated and retrospectively summarized after long-term follow-up. Eight more cases of peritoneal metastatic SPN from the PubMed database were also included in the analysis. RESULTS Peritoneal metastases of SPNs have different gross features. The benign nodules were tenacious and well encapsulated, while the malignant nodules were soft and prone to slow bleeding. However, neither of these nodules invaded the small intestines or mesentery. Of the 12 disseminated cases, 7 had history of primary tumor rupture, whereas the others had tumors malignant in nature. A total of 14 surgical events were documented, including 3 complete cytoreductive surgeries (CCRS), 9 cytoreductive surgeries (CRS), and 2 debulking surgeries. After follow-up ranging from 0.3 to 6.1 years, the results of the Fisher's exact test showed no difference between CCRS and CRS in treating either low-grade or high-grade malignant SPNs (P=0.257 and P=0.203, respectively). For all cases of SPN with peritoneal metastases, the CCRS procedure could significantly improve tumor-free survival (TFS) compared to the CRS procedure (P=0.046). CONCLUSIONS SPN rupture could cause significant peritoneal metastases, and either disruption or biopsy of these lesions should be avoided. Peritoneal metastases from SPNs vary both in gross features and biological mechanisms. CCRS may offer optimal therapeutic outcomes and longer TFS for individuals with significant peritoneal metastases of SPNs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

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[PMID]: 29511388
[Au] Autor:Meloni A; Palmas F; Barberini L; Mereu R; Deiana SF; Fais MF; Noto A; Fattuoni C; Mussap M; Ragusa A; Dessì A; Pintus R; Fanos V; Melis GB
[Ad] Address:Department of Surgical Sciences, Division of Gynaecology and Obstetrics, University of Cagliari, Cagliari, Italy.
[Ti] Title:PROM and Labour Effects on Urinary Metabolome: A Pilot Study.
[So] Source:Dis Markers;2018:1042479, 2018.
[Is] ISSN:1875-8630
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3). GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1155/2018/1042479

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[PMID]: 29506509
[Au] Autor:Zhang Z; Zhou M; Liu K; Zhu B; Liu H; Sun X; Xu X
[Ad] Address:Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.
[Ti] Title:Development of a new valid and reliable microsurgical skill assessment scale for ophthalmology residents.
[So] Source:BMC Ophthalmol;18(1):68, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: More and more concerns have been arisen about the ability of new medical graduates to meet the demands of today's practice environment. In this study, we wanted to develop a valid, reliable and standardized assessment tool for evaluating the basic microsurgical skills of residents in a microsurgery laboratory, to get them well prepared before entering the surgical realm of ophthalmology. METHODS: Twenty-three experts who have teaching experience reviewed the assessment scale. Constructive comments were incorporated to ensure face and content validity. Twenty-one attendings from different specialties then graded eight corneal rupture suturing videos with the scale to investigate interrater reliability. Fourteen of them graded the same videos 3 months later to investigate intrarater reliability (repeatability). RESULTS: A total of 280 assessment scales were completed. All the ICC values of interrater reliability were greater than 0.8 with 75% data greater than 0.9 (range 0.860-0.976). All the ICC values of intrarater reliability (repeatability) were also greater than 0.8 with 63% data greater than 0.9 (range 0.833-0.954). CONCLUSIONS: The assessment scale we developed is valid and reliable. This tool could be useful to ensure that junior residents achieve a certain level of microsurgical technique in a laboratory environment before training in the operation room. Hopefully, this tool will provide a structured template for other residency programs to assess their residents for basic microsurgical skills.
[Mh] MeSH terms primary: Clinical Competence/standards
Educational Measurement/methods
Internship and Residency
Microsurgery/education
Ophthalmologic Surgical Procedures/education
Ophthalmology/education
Suture Techniques/education
[Mh] MeSH terms secundary: Corneal Injuries/surgery
Humans
Reproducibility of Results
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[Js] Journal subset:IM
[Da] Date of entry for processing:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0736-z

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[PMID]: 29432910
[Au] Autor:de Barros PP; Scorzoni L; Ribeiro FC; Fugisaki LRO; Fuchs BB; Mylonakis E; Jorge AOC; Junqueira JC; Rossoni RD
[Ad] Address:Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP - Univ Estadual Paulista, Francisco Jose Longo 777, Sao Dimas, Sao Jose dos Campos, CEP: 12245-000, SP, Brazil. Electronic address: barrosdnapp@yahoo.com.br.
[Ti] Title:Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans.
[So] Source:Microb Pathog;117:80-87, 2018 Feb 09.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The objective of this study was to evaluate the influence of microbe-microbe interactions to identify a strain of Lactobacillus that could reduce the filamentation of Candida albicans ATCC 18804 using in vitro and in vivo models. Thus presenting a probiotic effect against the fungal pathogen. First, we analyzed the ability of 25 clinical isolates of Lactobacillus to reduce filamentation in C. albicans in vitro. We found that L. paracasei isolate 28.4 exhibited the greatest reduction of C. albicans hyphae (p = 0.0109). This reduction was confirmed by scanning electron microscopy analysis. The influence of C. albicans filamentation was found to be contributed through reduced gene expression of filament associated genes (TEC1 and UME6). In an in vivo study, prophylactic provisions with L. paracasei increased the survival of Caenorhabditis elegans worms infected with C. albicans (p = 0.0001) by 29%. Prolonged survival was accompanied by the prevention of cuticle rupture of 27% of the worms by filamentation of C. albicans, a phenotype that is characteristic of C. albicans killing of nematodes, compared to the control group. Lactobacillus paracasei isolate 28.4 reduced the filamentation of C. albicans in vitro by negatively regulating the TEC1 and UME6 genes that are essential for the production of hyphae. Prophylactic provision of Lactobacillus paracasei 28.4 protected C. elegans against candidiasis in vivo. L. paracasei 28.4 has the potential to be employed as an alternative method to control candidiasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 117146 MEDLINE  
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[PMID]: 29391177
[Au] Autor:Powers R; Hurley S; Park E; McArdle B; Vidal P; Psutka SP; Hollowell CMP
[Ad] Address:Division of Urology, John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois. Electronic address: rpowers@cookcountyhhs.org.
[Ti] Title:Usefulness of Preoperative Ultrasound for the Evaluation of Testicular Rupture in the Setting of Scrotal Gunshot Wounds.
[So] Source:J Urol;, 2018 Jan 31.
[Is] ISSN:1527-3792
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: A scrotal gunshot wound may result in testicular injury, necessitating urgent scrotal exploration and attempted testicular salvage. Scrotal ultrasound is highly sensitive and specific for testicular rupture in the setting of blunt scrotal trauma but it has been poorly studied in the setting of scrotal gunshot wounds. Our objective was to determine the accuracy of scrotal ultrasound to identify testicular rupture following a scrotal gunshot wound. MATERIALS AND METHODS: We retrospectively reviewed the records of patients with a scrotal gunshot wound from 2003 to 2014 in whom preoperative ultrasound was done prior to scrotal exploration. A heterogeneous echo pattern of testicular parenchyma with contour loss was considered a positive examination for testicular rupture. Patients underwent scrotal exploration within 24 hours of presentation. The sensitivity and specificity of ultrasound were estimated and compared to operative findings. ROC curve analysis was done. RESULTS: Of 75 patients who sustained a scrotal gunshot wound ultrasound was positive in 30 and negative in 45. No ultrasound revealed bilateral injuries. Scrotal exploration demonstrated a total of 40 testicular ruptures in 35 patients, of which 30 testicles were salvaged. Ten orchiectomies were performed. The sensitivity and specificity of ultrasound were 60% and 95%, respectively, with 16 missed injuries and 6 false-positive findings. Positive predictive value was 80% and negative predictive value was 87%. The ROC AUC was 0.79. In 6 of the 16 missed injuries there was an ipsilateral hematocele or hematoma. CONCLUSIONS: The sensitivity of scrotal ultrasound is limited for evaluating testicular rupture after a scrotal gunshot wound. Large coincident hematoceles or hematomas may obscure the diagnosis of testicular rupture. Negative ultrasound should not preclude scrotal exploration after a scrotal gunshot wound is sustained.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29381243
[Au] Autor:Xu K; Pan X; Qiu X; Wang D; Dong N; Yang L; Li S
[Ad] Address:Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
[Ti] Title:Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling.
[So] Source:Wound Repair Regen;, 2018 Jan 30.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:During tendon injuries, nerve ingrowth is one of the earliest events of tendon repair and remodeling. Since peripheral neurons and associated cells are mostly derived from neural crest (NC) cells, we sought to investigate the role of NC-derived cells in tendon regeneration. Thus, we used Sox10-Cre/ROSA26-Flox-Red Fluorescent Protein (RFP) transgenic mice to trace these cells during tendon regeneration. After 4 weeks of Achilles tendon rupture, the injured tendon tissues were harvested for immunohistological analyses, cell isolation, and phenotype identification. In addition, the tenocytes were co-cultured with RFP labeled cells to examine cellular functions. Following the injury, a significant number of RFP-labeled cells penetrated into the wound site and reached a peak (∼30% of cells) after 2 weeks, and then stabilized at a level of approximately 20%. Interestingly, 36.9% RFP labeled cells in the injured area expressed Tuj1, suggesting that most of the cells are peripheral neurons. Some RFP /Tuj1 cells were also found adjacent to newly formed blood vessels in the tendon. Importantly, the existing neuropeptide Y (NPY) and neuropeptide Y receptor (NPYr) in the ingrowth nerve and blood vessels showed the direct correlation with each other. In addition, there were also RFP cells (∼30%) negative for neuron markers but positive for fibroblast markers, that is, FAP (34.7%) and Vimentin (Vmt) (27.2%), and approximately 10% positive for Sox10. Indeed, many RFP cells isolated from the ruptured Achilles tendon showed long spindle shapes and expressed fibroblast phenotypic markers FSP1 and FAP. Particularly, part of the Sox10 RFP-labeled cells exhibited osteogenic and adipogenic differentiation ability. It is concluded that after Achilles tendon injury, nerves sprout into the wound site. The NC-derived Vmt /FAP mesenchymal cells and peripheral nerves participate in tendon regeneration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/wrr.12614

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[PMID]: 29524249
[Au] Autor:Habeck M; Nguyen T
[Ad] Address:Statistical Inverse Problems in Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
[Ti] Title:A probabilistic network model for structural transitions in biomolecules.
[So] Source:Proteins;, 2018 Mar 09.
[Is] ISSN:1097-0134
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Biological macromolecules often undergo large conformational rearrangements during a functional cycle. To simulate these structural transitions with full atomic detail typically demands extensive computational resources. Moreover, it is unclear how to incorporate, in a principled way, additional experimental information that could guide the structural transition. This article develops a probabilistic model for conformational transitions in biomolecules. The model can be viewed as a network of anharmonic springs that break, if the experimental data support the rupture of bonds. Hamiltonian Monte Carlo in internal coordinates is used to infer structural transitions from experimental data, thereby sampling large conformational transitions without distorting the structure. The model is benchmarked on a large set of conformational transitions. Moreover we demonstrate the use of the probabilistic network model for integrative modeling of macromolecular complexes based on data from crosslinking followed by mass spectrometry. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1002/prot.25490

  10 / 117146 MEDLINE  
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[PMID]: 29524060
[Au] Autor:Lima WG; Alves MC; Cruz WS; Paiva MC
[Ad] Address:Laboratory of Medical Microbiology, Central-West Campus Dona Lindu, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Divinopolis, Minas Gerais, 35501-293, Brazil. williamgustavo_1992@hotmail.com.
[Ti] Title:Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat.
[So] Source:Eur J Clin Microbiol Infect Dis;, 2018 Mar 09.
[Is] ISSN:1435-4373
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Acinetobacter baumannii is an opportunistic pathogen associated with nosocomial and community infections of great clinical relevance. Its ability to rapidly develop resistance to antimicrobials, especially carbapenems, has re-boosted the prescription and use of polymyxins. However, the emergence of strains resistant to these antimicrobials is becoming a critical issue in several regions of the world because very few of currently available antibiotics are effective in these cases. This review summarizes the most up-to-date knowledge about chromosomally encoded and plasmid-mediated polymyxins resistance in A. baumannii. Different mechanisms are employed by A. baumannii to overcome the antibacterial effects of polymyxins. Modification of the outer membrane through phosphoethanolamine addition, loss of lipopolysaccharide, symmetric rupture, metabolic changes affecting osmoprotective amino acids, and overexpression of efflux pumps are involved in this process. Several genetic elements modulate these mechanisms, but only three of them have been described so far in A. baumannii clinical isolates such as mutations in pmrCAB, lpxACD, and lpsB. Elucidation of genotypic profiles and resistance mechanisms are necessary for control and fight against resistance to polymyxins in A. baumannii, thereby protecting this class for future treatment.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s10096-018-3223-9


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